8,793 results on '"Almazán A"'
Search Results
2. Approach to meson-baryon femtoscopy using effective field theories
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Almazán, Álvaro Peña and Torres-Rincon, Juan M.
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High Energy Physics - Phenomenology ,Nuclear Experiment ,Nuclear Theory - Abstract
We calculate several femtoscopy correlation functions in the strangeness sectors $S=0$ and $S=-2$ for meson-baryon interactions. We combine the amplitudes of chiral perturbation theory at leading order with the TROY (T-matrix-based Routine for HadrOn femtoscopY) framework. We consider the correlation function for the $\pi^+$p and $\pi^-$p channels, which are currently under analysis by the ALICE collaboration at the LHC. Furthermore, we will show that analogous interactions can be used to reproduce the results for $K_S \Lambda$ correlation functions obtained by ALICE collaboration in PbPb collisions., Comment: 1+4 pages, 2 figures. Contribution to the proceedings of the 10th International Conference on Quarks and Nuclear Physics (QNP2024)
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- 2024
3. KISS: instrument description and performance
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Macías-Pérez, J. F., Fernández-Torreiro, M., Catalano, A., Fasano, A., Aguiar, M., Beelen, A., Benoit, A., Bideaud, A., Bounmy, J., Bourrion, O., Calvo, M., Castro-Almazán, J. A., de Bernardis, P., de Petris, M., de Taoro, A. P., Garde, G., Génova-Santos, R. T., Gomez, A., Gómez-Renasco, M. F., Goupy, J., Hoarau, C., Hoyland, R., Lagache, G., Marpaud, J., Marton, M., Masi, S., Monfardini, A., Peel, M. W., Pisano, G., Ponthieu, N., Rebolo, R., Roni, S., Roudier, S., Rubiño-Martín, J. A., Tourres, D., Tucker, C., Viera-Curvelo, T., and Vescovi, C.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Kinetic inductance detectors (KIDs) have been proven as reliable systems for astrophysical observations, especially in the millimetre range. Their compact size enables to optimally fill the focal plane, thus boosting sensitivity. The KISS (KIDs Interferometric Spectral Surveyor) instrument is a millimetre camera that consists of two KID arrays of 316 pixels each coupled to a Martin-Puplett interferometer (MPI). The addition of the MPI grants the KIDs camera the ability to provide spectral information in the 100 and 300 GHz range. In this paper we report the main properties of the KISS instrument and its observations. We also describe the calibration and data analysis procedures used. We present a complete model of the observed data including the sky signal and several identified systematics. We have developed a full photometric and spectroscopic data analysis pipeline that translates our observations into science-ready products. We show examples of the results of this pipeline on selected sources: Moon, Jupiter and Venus. We note the presence of a deficit of response with respect to expectations and laboratory measurements. The detectors noise level is consistent with values obtained during laboratory measurements, pointing to a sub-optimal coupling between the instrument and the telescope as the most probable origin for the problem. This deficit is large enough as to prevent the detection of galaxy clusters, which were KISS main scientific objective. Nevertheless, we have demonstrated the feasibility of this kind of instrument, in the prospect for other KID interferometers (such as the CONCERTO instrument). As this regard, we have developed key instrumental technologies such as optical conception, readout electronics and raw calibration procedures, as well as, adapted data analysis procedures., Comment: 23 pages, 15 figures. Accepted for publication in Publications of the Astronomical Society of the Pacific
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- 2024
4. Bioaccumulation of 238U and 239+240Pu in bivalve mollusks from different coastal areas of Mexico
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Almazán Torres, M. G., Almazán Martínez, M. S., Ordoñez Regil, E., and Ramírez Villalva, A.
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- 2025
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5. Effect of Different Karyophilic Peptides on Physical Characteristics and In Vitro Transfection Efficiency of Chitosan-Plasmid Nanoparticles as Nonviral Gene Delivery Systems
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Aranda-Barradas, María Eugenia, Coronado-Contreras, Héctor Eduardo, Aguilar-Castañeda, Yareli Lizbeth, Olivo-Escalante, Karen Donají, González-Díaz, Francisco Rodolfo, García-Tovar, Carlos Gerardo, Álvarez-Almazán, Samuel, Miranda-Castro, Susana Patricia, Del Real-López, Alicia, and Méndez-Albores, Abraham
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- 2025
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6. Interpretable machine learning models for COPD ease of breathing estimation
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Kok, Thomas T., Morales, John, Deschrijver, Dirk, Blanco-Almazán, Dolores, Groenendaal, Willemijn, Ruttens, David, Smeets, Christophe, Mihajlović, Vojkan, Ongenae, Femke, and Van Hoecke, Sofie
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- 2025
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7. A case of fish mortality caused by Prymnesium parvum in inland waters in Yucatan, Mexico
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Almazán-Becerril, Antonio, Delgado-Pech, Benjamín, Peniche-Pérez, Jorge Carlos, Arana-Ravell, Juan Manuel, and Caballero-Vázquez, José Adán
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- 2024
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8. Measurement of Energy Resolution with the NEXT-White Silicon Photomultipliers
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Contreras, T., Palmeiro, B., Almazán, H., Para, A., Martínez-Lema, G., Guenette, R., Adams, C., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Auria-Luna, F., Ayet, S., Azevedo, C. D. R., Bailey, K., Ballester, F., del Barrio-Torregrosa, M., Bayo, A., Benlloch-Rodríguez, J. M., Borges, F. I. G. M., Brodolin, A., Byrnes, N., Cárcel, S., Castillo, A., Cebrián, S., Church, E., Cid, L., Conde, C. A. N., Cossío, F. P., Dey, E., Díaz, G., Dickel, T., Echevarria, C., Elorza, M., Escada, J., Esteve, R., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Foss, F. W., Freixa, Z., García-Barrena, J., Gómez-Cadenas, J. J., González, R., Grocott, J. W. R., Hauptman, J., Henriques, C. A. O., Morata, J. A. Hernando, Herrero-Gómez, P., Herrero, V., Carrete, C. Hervés, Ifergan, Y., Jones, B. J. P., Kellerer, F., Larizgoitia, L., Larumbe, A., Lebrun, P., Lopez, F., López-March, N., Madigan, R., Mano, R. D. P., Marques, A. P., Martín-Albo, J., Martínez-Vara, M., Miller, R. L., Mistry, K., Molina-Canteras, J., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Navarro, K. E., Novella, P., Nuñez, A., Nygren, D. R., Oblak, E., Palacio, J., Parmaksiz, I., Pazos, A., Pelegrin, J., Maneiro, M. Pérez, Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rogero, C., Rogers, L., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Seemann, M., Shomroni, I., Silva, P. A. O. C., Simón, A., Soleti, S. R., Sorel, M., Soto-Oton, J., Teixeira, J. M. R., Teruel-Pardo, S., Toledo, J. F., Tonnelé, C., Torrent, J., Trettin, A., Usón, A., Valle, P. R. G., Veloso, J. F. C. A., Waiton, J., and Yubero-Navarro, A.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
The NEXT-White detector, a high-pressure gaseous xenon time projection chamber, demonstrated the excellence of this technology for future neutrinoless double beta decay searches using photomultiplier tubes (PMTs) to measure energy and silicon photomultipliers (SiPMs) to extract topology information. This analysis uses $^{83m}\text{Kr}$ data from the NEXT-White detector to measure and understand the energy resolution that can be obtained with the SiPMs, rather than with PMTs. The energy resolution obtained of (10.9 $\pm$ 0.6) $\%$, full-width half-maximum, is slightly larger than predicted based on the photon statistics resulting from very low light detection coverage of the SiPM plane in the NEXT-White detector. The difference in the predicted and measured resolution is attributed to poor corrections, which are expected to be improved with larger statistics. Furthermore, the noise of the SiPMs is shown to not be a dominant factor in the energy resolution and may be negligible when noise subtraction is applied appropriately, for high-energy events or larger SiPM coverage detectors. These results, which are extrapolated to estimate the response of large coverage SiPM planes, are promising for the development of future, SiPM-only, readout planes that can offer imaging and achieve similar energy resolution to that previously demonstrated with PMTs.
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- 2024
9. Characterizing Novel Indium Phosphide Pad Detectors with Focused X-ray Beams and Laboratory Tests
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Almazan, Earl, Affolder, Anthony, Dyckes, Ian, Fadeyev, Vitaliy, Hance, Michael, Jadhav, Manoj, Kim, Sungjoon, McCoy, Thomas, Metcalfe, Jessica, Nielsen, Jason, Ott, Jennifer, Poley, Luise, Shin, Taylor, Sperlich, Dennis, and Sumant, Anirudha V.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
Future tracking systems in High Energy Physics experiments will require large instrumented areas with low radiation length. Crystalline silicon sensors have been used in tracking systems for decades, but are difficult to manufacture and costly to produce for large areas. We are exploring alternative sensor materials that are amenable to fast fabrication techniques used for thin film devices. Indium Phosphide pad sensors were fabricated at Argonne National Lab using commercially available InP:Fe 2-inch mono-crystal substrates. Current-voltage and capacitance-voltage characterizations were performed to study the basic operating characteristics of a group of sensors. Micro-focused X-ray beams at Canadian Light Source and Diamond Light Source were used to study the response to ionizing radiation, and characterize the uniformity of the response for several devices. The results show a high degree of performance uniformity in our evaluations, both within a device and between the 48 tested devices. This motivates further studies into thin film devices for future tracking detectors., Comment: 30 pages, 27 figures
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- 2024
10. Fluorescence Imaging of Individual Ions and Molecules in Pressurized Noble Gases for Barium Tagging in $^{136}$Xe
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NEXT Collaboration, Byrnes, N., Dey, E., Foss, F. W., Jones, B. J. P., Madigan, R., McDonald, A., Miller, R. L., Navarro, K. E., Norman, L. R., Nygren, D. R., Adams, C., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Auria-Luna, F., Ayet, S., Azevedo, C. D. R., Barcelon, J. E., Bailey, K., Ballester, F., del Barrio-Torregrosa, M., Bayo, A., Benlloch-Rodríguez, J. M., Borges, F. I. G. M., Brodolin, A., Cárcel, S., Castillo, A., Cebrián, S., Church, E., Cid, L., Conde, C. A. N., Contreras, T., Cossío, F. P., Díaz, G., Dickel, T., Echevarria, C., Elorza, M., Escada, J., Esteve, R., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Freixa, Z., García-Barrena, J., Gómez-Cadenas, J. J., González, R., Grocott, J. W. R., Guenette, R., Hauptman, J., Henriques, C. A. O., Morata, J. A. Hernando, Herrero-Gómez, P., Herrero, V., Carrete, C. Hervés, Ho, P., Ifergan, Y., Kellerer, F., Larizgoitia, L., Larumbe, A., Lebrun, P., Lopez, F., López-March, N., Mano, R. D. P., Marques, A. P., Martín-Albo, J., Martínez-Lema, G., Martínez-Vara, M., Mistry, K., Molina-Canteras, J., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Novella, P., Nuñez, A., Oblak, E., Palacio, J., Palmeiro, B., Para, A., Parmaksiz, I., Pazos, A., Pelegrin, J., Maneiro, M. Pérez, Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rogero, C., Rogers, L., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Seemann, M., Shomroni, I., Silva, P. A. O. C., Simón, A., Soleti, S. R., Sorel, M., Soto-Oton, J., Teixeira, J. M. R., Teruel-Pardo, S., Toledo, J. F., Tonnelé, C., Torrent, J., Trettin, A., Usón, A., Valle, P. R. G., Veloso, J. F. C. A., Waiton, J., and Yubero-Navarro, A.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
The imaging of individual Ba$^{2+}$ ions in high pressure xenon gas is one possible way to attain background-free sensitivity to neutrinoless double beta decay and hence establish the Majorana nature of the neutrino. In this paper we demonstrate selective single Ba$^{2+}$ ion imaging inside a high-pressure xenon gas environment. Ba$^{2+}$ ions chelated with molecular chemosensors are resolved at the gas-solid interface using a diffraction-limited imaging system with scan area of 1$\times$1~cm$^2$ located inside 10~bar of xenon gas. This new form of microscopy represents an important enabling step in the development of barium tagging for neutrinoless double beta decay searches in $^{136}$Xe, as well as a new tool for studying the photophysics of fluorescent molecules and chemosensors at the solid-gas interface.
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- 2024
11. Inhomogeneous probes for BCDI: Toward the imaging of dynamic and distorted crystals
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Calvo-Almazán, I., Chamard, V., Grünewald, T., and Allain, M.
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Physics - Optics ,Condensed Matter - Materials Science - Abstract
This work proposes an innovative approach to improve Bragg coherent diffraction imaging (BCDI) microscopy applied to time evolving crystals and/or non-homogeneous crystalline strain fields, identified as two major limitations of BCDI microscopy. Speckle BCDI (spBCDI), introduced here, rests on the ability of a strongly non-uniform illumination to induce a convolution of the three-dimensional (3D) frequency content associated with the finite-size crystal and a kernel acting perpendicularly to the illumination beam. In the framework of Bragg diffraction geometry, this convolution is beneficial as it encodes some 3D information about the sample in a single two-dimensional (2D) measurement, i.e., in the detector plane. With this approach, we demonstrate that we can drastically reduce the sampling frequency along the rocking curve direction and still obtain data sets with enough information to be inverted by a traditional phase retrieval algorithm. Numerical simulations, performed for a highly distorted crystal, show that spBCDI allows a gain in the sampling ratio ranging between 4 and 20 along the rocking curve scan, for a speckle illumination with individual speckle size of 50 nm. Furthermore, spBCDI allows working at low intensity levels, leading to an additional gain for the total scanning time. Reductions of a factor of about 32 were numerically observed. Thus, measurements in the 0.3 s time scale at 4th generation synchrotrons become feasible, with a remarkable performance for the imaging of strongly distorted crystals. Practical details on the implementation of the method are also discussed., Comment: 17 pages, 11 figures
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- 2024
12. Vibration-based monitoring of a cross-laminated timber building in a high seismicity zone
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Jara-Cisterna, Alan, Benedetti, Franco, Rosales, Victor, Almazán, José Luis, and Opazo-Vega, Alexander
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- 2024
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13. Integral field spectroscopy supports atmospheric optics to reveal the finite outer scale of the turbulence
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García-Lorenzo, Begoña, Esparza-Arredondo, Donaji, Acosta-Pulido, Jose A., and Castro-Almazán, Julio A.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The spatial coherence wavefront outer scale (L_0) characterizes the size of the largest turbulence eddies in Earth's atmosphere, determining low spatial frequency perturbations in the wavefront of the light captured by ground-based telescopes. The motivation of this work is to introduce a novel technique for estimating L_0 from seeing-limited integral field spectroscopic (IFS) data. This approach is based on the impact of a finite L_0 on the light collected by the pupil entrance of a ground-based telescope. We take advantage of the homogeneity of IFS to generate band filter images spanning a wide wavelength range, enabling the assessment of image quality (IQ) at the telescope's focal plane. Comparing the measured wavelength-dependent IQ variation with predictions from Tokovinin (2002) analytical approach offers valuable insights into the prevailing L_0 parameter during the observations. We applied the proposed technique to observations from MUSE in the Wide Field Mode obtained at the Paranal Observatory. Our analysis successfully validates Tokovinin's analytical expression, which combines the seeing (E_0) and the L_0 parameters, to predict the IQ variations with the wavelength in ground-based astronomical data. However, we observed some discrepancies between the measured and predictions of the IQ that are analyzed in terms of uncertainties in the estimated E_0 and dome-induced turbulence contributions. This work constitutes the empirical validation of the analytical expression for estimating IQ at the focal plane of ground-based telescopes under specific E_0 and finite L_0 conditions. Additionally, we provide a simple methodology to characterize the L_0 and dome-seeing (E_d) as by-products of IFS observations routinely conducted at major ground-based astronomical observatories., Comment: 25 pages, 18 figures
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- 2024
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14. Phylogenetic relationships of two poorly known Honduran treefrogs (Hylidae, Hylinae, Hylini) : review, revisions, and three new species
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Chaves-Acuña, Wagner, Boza-Oviedo, Eduardo, Zúniga Betanco, Javier Antonio, Chaves Cordero, Gerardo Antonio, Bolaños, Federico, McCranie, James R., Vásquez-Almazán, Carlos R., Faivovich, Julián, American Museum of Natural History Library, Chaves-Acuña, Wagner, Boza-Oviedo, Eduardo, Zúniga Betanco, Javier Antonio, Chaves Cordero, Gerardo Antonio, Bolaños, Federico, McCranie, James R., Vásquez-Almazán, Carlos R., and Faivovich, Julián
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Classification ,Frogs ,Honduras ,Hylidae ,Phylogeny - Published
- 2024
15. Flexible visual prompts for in-context learning in computer vision
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Foster, Thomas, Croitoru, Ioana, Dorfman, Robert, Edlund, Christoffer, Varsavsky, Thomas, and Almazán, Jon
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In this work, we address in-context learning (ICL) for the task of image segmentation, introducing a novel approach that adapts a modern Video Object Segmentation (VOS) technique for visual in-context learning. This adaptation is inspired by the VOS method's ability to efficiently and flexibly learn objects from a few examples. Through evaluations across a range of support set sizes and on diverse segmentation datasets, our method consistently surpasses existing techniques. Notably, it excels with data containing classes not encountered during training. Additionally, we propose a technique for support set selection, which involves choosing the most relevant images to include in this set. By employing support set selection, the performance increases for all tested methods without the need for additional training or prompt tuning. The code can be found at https://github.com/v7labs/XMem_ICL/.
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- 2023
16. The spanish and catalan versions of the kidney patient reported experience measure (PREM) for chronic kidney disease (CKD): cultural adaptation and face validity
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Moharra, M., Llupià, A., Bayés, B., Almazán, C., Busby, A., and Herdman, M.
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- 2024
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17. Endurance and electromyographic assessment of abdominopelvic motor control in women with primary dysmenorrhea: a cross-sectional study
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del Prado-Álvarez, Rebeca, Estrada-Barranco, Cecilia, González-de-la-Flor, Ángel, de la Plaza San Frutos, Marta, Almazán-Polo, Jaime, Guerineau, Fabien, Giménez, María-José, and García-Arrabé, María
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- 2024
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18. Encapsulation of soybean lunasin and amaranth unsaponifiable matter in liposomes induces cell cycle arrest in an allograft melanoma mouse model
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Castañeda-Reyes, Erick Damián, Gonzalez-Almazán, Alejandro, Lubbert-Licón, Alán, Yahya, Najwa Farhana, and Gonzalez de Mejia, Elvira
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- 2024
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19. Dietary bisphenols exposure as an influencing factor of body mass index
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Gálvez-Ontiveros, Yolanda, Monteagudo, Celia, Giles-Mancilla, María, Muros, José Joaquín, Almazán, Vega, Martínez-Burgos, María Alba, Samaniego-Sánchez, Cristina, Salcedo-Bellido, Inmaculada, Rivas, Ana, and Zafra-Gómez, Alberto
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- 2024
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20. Translation and validation of the COPD Patient Reported Experience Measure (PREM-C9) in Spanish and Catalan
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Moharra, M., Llupià, A., Bayés, B., Escarrabill, J., and Almazán, C.
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- 2024
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21. Critical habitats: climate change and habitat loss as drivers of change in the geographic ranges of Neotropical woodcreepers (Aves: Furnariidae) in Mexico
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Salazar-Miranda, Rosa I., Toro-Cardona, Felipe A., Rojas-Soto, Octavio, Sierra-Morales, Pablo, Ríos-Muñoz, César A., and Almazán-Núñez, Roberto Carlos
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- 2024
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22. Dose-response relationship of high-intensity training on global cognition in older adults with mild cognitive impairment or dementia: a systematic review with meta-analysis - the ACHIEVE-Study
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Afanador-Restrepo, Diego Fernando, Casanova-Correa, Alejandro, Martín-Ojeda, Rita Inés, Aibar-Almazán, Agustín, González-Martín, Ana María, Hita-Contreras, Fidel, del Carmen Carcelén-Fraile, María, and Castellote-Caballero, Yolanda
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- 2024
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23. Effect of combined physical–cognitive training on the functional and cognitive capacity of older people with mild cognitive impairment: a randomized controlled trial
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Castellote-Caballero, Yolanda, Carcelén Fraile, María del Carmen, Aibar-Almazán, Agustín, Afanador-Restrepo, Diego Fernando, and González-Martín, Ana María
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- 2024
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24. Improvement of metabolic syndrome and its components in patients who underwent transsphenoidal resection for pituitary adenoma
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Cortés-Contreras, A. P., Salazar-Pigeon, A., González-Almazán, J. A., Flores-Rabasa, R., Navarro-Olvera, J. L., Méndez-García, L. A., and Carrillo-Ruiz, J. D.
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- 2024
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25. Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism
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Isabel Barón-Mendoza, Luis A. Márquez, Aliesha González Arenas, Jessica Guzmán-Condado, Vladimir A. Martínez-Rojas, Johaly Anguiano-Buenfil, Montserrat Mejía-Hernández, Jorge Luis Almazán, Leonor Pérez-Martínez, Gustavo Pedraza-Alva, Emilio J. Galván, and Angélica Zepeda
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Neurodevelopmental disorders ,Hippocampus ,Neurophysiology ,Long term potentiation ,Contextual fear memory ,Spatial memory ,Medicine ,Science - Abstract
Abstract Autism spectrum disorder (ASD) comprises alterations in brain anatomy and physiology that ultimately affect information processing and behavior. In most cases, autism is considered idiopathic, involving alterations in numerous genes whose functions are not extensively documented. We evaluated the C58/J mouse strain as an idiopathic model of ASD, emphasizing synaptic transmission as the basis of information processing. Through in silico analysis, we found that the C58/J strain carries single nucleotide polymorphisms (SNPs) compared to the C57BL/6J control strain related to synaptic structure and LTP induction. These SNPs have human orthologs previously associated with ASD. We then assessed chemical potentiation (cLTP) in synaptosomes, the electrophysiological properties of hippocampal CA3 cells, and the induction of LTP in ex-vivo slices. An increased proportion of synaptosomes expressing the GluA1 subunit of AMPA receptor and Nrx1β in the membrane was found in the C57BL/6J control strain, but not in C58/J mice, after cLTP induction. Additionally, several electrophysiological properties of CA3 pyramidal cells and hippocampal communication were altered. Behaviorally, C58/J mice exhibited hyperactivity and subtle memory changes. Our results demonstrate that an idiopathic model of ASD exhibits alterations in hippocampal physiology from the cellular to the circuitry and behavioral levels.
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- 2025
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26. Design, characterization and installation of the NEXT-100 cathode and electroluminescence regions
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NEXT Collaboration, Mistry, K., Rogers, L., Jones, B. J. P., Munson, B., Norman, L., Adams, C., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Auria-Luna, F., Ayet, S., Azevedo, C. D. R., Bailey, K., Ballester, F., del Barrio-Torregrosa, M., Bayo, A., Benlloch-Rodríguez, J. M., Borges, F. I. G. M., Brodolin, A., Byrnes, N., Cárcel, S., Castillo, A., Cebrián, S., Church, E., Cid, L., Conde, C. A. N., Contreras, T., Cossío, F. P., Dey, E., Díaz, G., Dickel, T., Echevarria, C., Elorza, M., Escada, J., Esteve, R., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Foss, F. W., Freitas, E. D. C., Freixa, Z., Gómez-Cadenas, J. J., González, R., Grocott, J. W. R., Guenette, R., Hafidi, K., Hauptman, J., Henriques, C. A. O., Hernando~Morata, J. A., Herrero-Gómez, P., Herrero, V., Carrete, C. Hervés, Ifergan, Y., Larizgoitia, L., Larumbe, A., Lebrun, P., Lopez, F., López-March, N., Madigan, R., Mano, R. D. P., Marques, A. P., Martín-Albo, J., Martínez-Lema, G., Martínez-Vara, M., Meziani, Z. E., Miller, R. L., Molina-Canteras, J., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Navarro, K. E., Novella, P., Nuñez, A., Nygren, D. R., Oblak, E., Oliver, D., Palacio, J., Palmeiro, B., Para, A., Parmaksiz, I., Pelegrin, J., Maneiro, M. Pérez, Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rogero, C., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Seemann, M., Shomroni, I., Simón, A., Soleti, S. R., Sorel, M., Soto-Oton, J., Teixeira, J. M. R., Toledo, J. F., Torrent, J., Trettin, A., Usón, A., Veloso, J. F. C. A., Waiton, J., and Yubero, A.
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Physics - Instrumentation and Detectors - Abstract
NEXT-100 is currently being constructed at the Laboratorio Subterr\'aneo de Canfranc in the Spanish Pyrenees and will search for neutrinoless double beta decay using a high-pressure gaseous time projection chamber (TPC) with 100 kg of xenon. Charge amplification is carried out via electroluminescence (EL) which is the process of accelerating electrons in a high electric field region causing secondary scintillation of the medium proportional to the initial charge. The NEXT-100 EL and cathode regions are made from tensioned hexagonal meshes of 1 m diameter. This paper describes the design, characterization, and installation of these parts for NEXT-100. Simulations of the electric field are performed to model the drift and amplification of ionization electrons produced in the detector under various EL region alignments and rotations. Measurements of the electrostatic breakdown voltage in air characterize performance under high voltage conditions and identify breakdown points. The electrostatic deflection of the mesh is quantified and fit to a first-principles mechanical model. Measurements were performed with both a standalone test EL region and with the NEXT-100 EL region before its installation in the detector. Finally, we describe the parts as installed in NEXT-100, following their deployment in Summer 2023., Comment: 35 pages, 25 Figures, update includes accepted version in JINST
- Published
- 2023
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27. Demonstration of Event Position Reconstruction based on Diffusion in the NEXT-White Detector
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Haefner, J., Navarro, K. E., Guenette, R., Jones, B. J. P., Tripathi, A., Adams, C., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Auria-Luna, F., Ayet, S., Azevedo, C. D. R., Bailey, K., Ballester, F., del Barrio-Torregrosa, M., Bayo, A., BenllochRodríguez, J. M., Borges, F. I. G. M., Brodolin, A., Byrnes, N., Cárcel, S., Carrión, J. V., Cebrián, S., Church, E., Cid, L., Conde, C. A. N., Contreras, T., Cossío, F. P., Dey, E., Díaz, G., Dickel, T., Elorza, M., Escada, J., Esteve, R., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Foss, F. W., Freitas, E. D. C., Freixa, Z., Generowicz, J., Goldschmidt, A., Gómez-Cadenas, J. J., González, R., Grocott, J., Hafidi, K., Hauptman, J., Henriques, C. A. O., Morata, J. A. Hernando, Herrero-Gómez, P., Herrero, V., Carrete, C. Hervés, Ifergan, Y., Labarga, L., Larizgoitia, L., Larumbe, A., Lebrun, P., Lopez, F., López-March, N., Madigan, R., Mano, R. D. P., Marques, A. P., Martín-Albo, J., Martínez-Lema, G., Martínez-Vara, M., Meziani, Z. E., Miller, R. L., Mistry, K., Molina-Canteras, J., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Vidal, J. Muñoz, Novella, P., Nuñez, A., Nygren, D. R., Oblak, E., Palacio, J., Palmeiro, B., Para, A., Parmaksiz, I., Pelegrin, J., Maneiro, M. Pérez, Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rodríguez, J., Rogero, C., Rogers, L., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Shomroni, I., Simón, A., Soleti, S. R., Sorel, M., Soto-Oton, J., Teixeira, J. M. R., Toledo, J. F., Torrent, J., Trettin, A., Usón, A., Veloso, J. F. C. A., Waiton, J., and White, J. T.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
Noble element time projection chambers are a leading technology for rare event detection in physics, such as for dark matter and neutrinoless double beta decay searches. Time projection chambers typically assign event position in the drift direction using the relative timing of prompt scintillation and delayed charge collection signals, allowing for reconstruction of an absolute position in the drift direction. In this paper, alternate methods for assigning event drift distance via quantification of electron diffusion in a pure high pressure xenon gas time projection chamber are explored. Data from the NEXT-White detector demonstrate the ability to achieve good position assignment accuracy for both high- and low-energy events. Using point-like energy deposits from $^{83\mathrm{m}}$Kr calibration electron captures ($E\sim45$keV), the position of origin of low-energy events is determined to $2~$cm precision with bias $< 1$mm. A convolutional neural network approach is then used to quantify diffusion for longer tracks (E$\geq$1.5MeV), yielding a precision of 3cm on the event barycenter. The precision achieved with these methods indicates the feasibility energy calibrations of better than 1% FWHM at Q$_{\beta\beta}$ in pure xenon, as well as the potential for event fiducialization in large future detectors using an alternate method that does not rely on primary scintillation., Comment: 18 pages, 16 figures
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- 2023
28. Split gluon masses in $SU(N)\times SU(M)$ theories
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Concejo, Julia Gómez, Llanes-Estrada, Felipe J., María-Almazán, Diego, and Salas-Bernárdez, Alexandre
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High Energy Physics - Phenomenology - Abstract
We extend a known mass-gap equation for pure gluodynamics in global colour models (formulated in equal time quantization in Coulomb gauge) to one in which gluons split into two sets which may have different masses. If the theory is $SU(N)\times SU(M)$ with gluons in both groups having identical couplings (as suggested by Grand Unification arguments at large scales) it is immediate to see that different masses are generated for each subgroup. This global symmetry is not broken, but the split masses erase accidental symmetries that might be present due to the two couplings being the same at the large scale, such as $SU(N\times M)$ or similar. We also numerically explore a couple of low-dimensional examples of simple Lie groups, but in spite of the system having a form that would seem to allow spontaneous symmetry breaking, it is not triggered for these groups whose algebra has no ideal, and the dispersion relations for the various gluons converge to the same form.
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- 2023
29. How studies on zoonotic risks in wildlife implement the one health approach – A systematic review
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Caroline Kuhn, Kenneth Mawuta Hayibor, Ama Twumwaa Acheampong, Luciana Salini Abrahão Pires, Magda Clara Vieira Costa-Ribeiro, María Soledad Burrone, Carlos Roberto Vásquez-Almazán, Katja Radon, María Teresa Solis Soto, Abrahão Pires Luciana Salini, Adler Marcia, Burrone María Soledad, da Costa Ribeiro Magda Clara Vieira, de Almeida Gustavo Araújo, de Carvalho Denise Siqueira, de Tarso Pires Paulo, Encina Zamorra Veronica, Garrido Marie Astrid, Guzmán-Quilo Maria Carolina, Kuhn Caroline, Magalhães Buffon Marilene da Cruz, Mansilla Vivar Pilar Macarena, Mendez Heredia Dennis Martin, Perez Morales Fabiana Marcela, Pinto Navia Carlos Fernando, Radon Katja, Ribeiro de Almeida Tatjana Queiroz, Solis Soto María Teresa, and Vásquez-Almazán Carlos Roberto
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One health ,Zoonoses ,Wild animals ,Interdisciplinary research ,Medicine (General) ,R5-920 - Abstract
Background: The recent COVID-19 pandemic and the emergence of infectious diseases at the human-animal interface highlight the global challenge of mitigating zoonotic risks. The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, urging for holistic and interdisciplinary strategies in disease prevention. Despite growing interest, the attention to wildlife in pandemic prevention remains limited. This systematic literature review aims to evaluate recent One Health research on zoonotic diseases and wildlife in terms of study design, interdisciplinary collaboration, and participatory approaches. Key questions addressed include the consideration of One Health domains, disciplinary involvement, and the inclusion of non-academic stakeholders. Methods: Following PRISMA guidelines, PubMed and Web of Science were searched for primary research papers on zoonotic diseases and wildlife from 2018 to 2023. Eligibility criteria included a focus on wildlife, zoonotic diseases, and adoption of the One Health approach. Results: A total of 228 primary research papers were retrieved. Out of these, 105 studies were included in the review. Few studies integrated human, animal, and environmental domains simultaneously in data collection (4.8 %) and knowledge generation (29.5 %). While extensive knowledge was generated for animal health (97.1 %) and human health (84.8 %), environmental health (34.3 %) remained underrepresented. Laboratory methods predominated (82.9 %), with limited integration of social science methodologies (19 %). The majority were epidemiological studies (86.7 %), yet analytical design within these was sparse (17.1 %). Participation of non-academic stakeholders was limited (36.2 % included non-academics; 3.8 % encompassed participative approaches). Conclusions: The synthesis of the domains human, animal and environmental health remained fragmentary in the studies reviewed. Environmental health is underrepresented and the interdisciplinary involvement of social sciences lacks. Neglecting these fields of competence impedes comprehensive understanding of disease dynamics and hampers effective zoonosis prevention strategies. In result, greater inter- and transdisciplinary collaboration, along with participatory approaches, are still needed for advancing One Health research.
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- 2024
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30. Demonstration of event position reconstruction based on diffusion in the NEXT-white detector
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Haefner, J, Navarro, KE, Guenette, R, Jones, BJP, Tripathi, A, Adams, C, Almazán, H, Álvarez, V, Aparicio, B, Aranburu, AI, Arazi, L, Arnquist, IJ, Auria-Luna, F, Ayet, S, Azevedo, CDR, Bailey, K, Ballester, F, Barrio-Torregrosa, M del, Bayo, A, Benlloch-Rodríguez, JM, Borges, FIGM, Brodolin, A, Byrnes, N, Cárcel, S, Carrión, JV, Cebrián, S, Church, E, Cid, L, Conde, CAN, Contreras, T, Cossío, FP, Dey, E, Díaz, G, Dickel, T, Elorza, M, Escada, J, Esteve, R, Felkai, R, Fernandes, LMP, Ferrario, P, Ferreira, AL, Foss, FW, Freitas, EDC, Freixa, Z, Generowicz, J, Goldschmidt, A, Gómez-Cadenas, JJ, González, R, Grocott, J, Hafidi, K, Hauptman, J, Henriques, CAO, Morata, JA Hernando, Herrero-Gómez, P, Herrero, V, Hervés Carrete, C, Ifergan, Y, Labarga, L, Larizgoitia, L, Larumbe, A, Lebrun, P, Lopez, F, López-March, N, Madigan, R, Mano, RDP, Marques, AP, Martín-Albo, J, Martínez-Lema, G, Martínez-Vara, M, Meziani, ZE, Miller, RL, Mistry, K, Molina-Canteras, J, Monrabal, F, Monteiro, CMB, Mora, FJ, Muñoz Vidal, J, Novella, P, Nuñez, A, Nygren, DR, Oblak, E, Palacio, J, Palmeiro, B, Para, A, Parmaksiz, I, Pelegrin, J, Pérez Maneiro, M, Querol, M, Redwine, AB, Renner, J, Rivilla, I, Rodríguez, J, Rogero, C, Rogers, L, Romeo, B, Romo-Luque, C, Santos, FP, dos Santos, JMF, Shomroni, I, and Simón, A
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Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Quantum Physics ,Nuclear & Particles Physics ,Astronomical sciences ,Atomic ,molecular and optical physics ,Particle and high energy physics - Abstract
Noble element time projection chambers are a leading technology for rare event detection in physics, such as for dark matter and neutrinoless double beta decay searches. Time projection chambers typically assign event position in the drift direction using the relative timing of prompt scintillation and delayed charge collection signals, allowing for reconstruction of an absolute position in the drift direction. In this paper, alternate methods for assigning event drift distance via quantification of electron diffusion in a pure high pressure xenon gas time projection chamber are explored. Data from the NEXT-White detector demonstrate the ability to achieve good position assignment accuracy for both high- and low-energy events. Using point-like energy deposits from 83mKr calibration electron captures (E∼45 keV), the position of origin of low-energy events is determined to 2 cm precision with bias
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- 2024
31. Increased levels of regulatory T cells and IL-10-producing regulatory B cells are linked to improved clinical outcome in Parkinson’s disease: a 1-year observational study
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Arce-Sillas, Asiel, Álvarez-Luquín, Diana Denisse, Leyva-Hernández, Jaquelin, Montes-Moratilla, Esteban, Vivas-Almazán, Viridiana, Pérez-Correa, Citzielli, Rodríguez-Ortiz, Ulises, Espinosa-Cárdenas, Raquel, Fragoso, Gladis, Sciutto, Edda, and Adalid-Peralta, Laura
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- 2024
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32. In vivo inhibition of the Ostreid Herpesvirus-1 (OsHV-1) replication in juveniles of the Pacific oyster Crassostrea gigas by a specific RNAi targeting the viral DNA polymerase gene
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Gallardo-Ybarra, Carolina, Sánchez-Paz, Arturo, Encinas-García, Trinidad, Minjarez-Osorio, Christian, Muhlia-Almazán, Adriana, Cruz-Villacorta, Ariel, Grijalva-Chon, José Manuel, and De La Re Vega, Enrique
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- 2024
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33. LEA: Improving Sentence Similarity Robustness to Typos Using Lexical Attention Bias
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Almagro, Mario, Almazán, Emilio, Ortego, Diego, and Jiménez, David
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Textual noise, such as typos or abbreviations, is a well-known issue that penalizes vanilla Transformers for most downstream tasks. We show that this is also the case for sentence similarity, a fundamental task in multiple domains, e.g. matching, retrieval or paraphrasing. Sentence similarity can be approached using cross-encoders, where the two sentences are concatenated in the input allowing the model to exploit the inter-relations between them. Previous works addressing the noise issue mainly rely on data augmentation strategies, showing improved robustness when dealing with corrupted samples that are similar to the ones used for training. However, all these methods still suffer from the token distribution shift induced by typos. In this work, we propose to tackle textual noise by equipping cross-encoders with a novel LExical-aware Attention module (LEA) that incorporates lexical similarities between words in both sentences. By using raw text similarities, our approach avoids the tokenization shift problem obtaining improved robustness. We demonstrate that the attention bias introduced by LEA helps cross-encoders to tackle complex scenarios with textual noise, specially in domains with short-text descriptions and limited context. Experiments using three popular Transformer encoders in five e-commerce datasets for product matching show that LEA consistently boosts performance under the presence of noise, while remaining competitive on the original (clean) splits. We also evaluate our approach in two datasets for textual entailment and paraphrasing showing that LEA is robust to typos in domains with longer sentences and more natural context. Additionally, we thoroughly analyze several design choices in our approach, providing insights about the impact of the decisions made and fostering future research in cross-encoders dealing with typos., Comment: KDD'23 conference (main research track). (*) These authors contributed equally
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- 2023
34. Rational application of the ESPGHAN 2022 recommendations for the follow-up of the paediatric coeliac patient: consensus document of scientific societies (SEGHNP, AEPAP, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG and SEMERGEN)
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Enriqueta Roman, Josefa Barrio, Maria Luz Cilleruelo, Ricardo Torres, Vega Almazán, Cristobal Coronel, Beatriz Espin, Eva Martinez-Ojinaga, David Perez Solís, Maria Antonia Moreno, Joaquín Reyes, Luis Fernandez Salazar, Sergio Farrais, Gemma Castillejo, Noelia Fontanillas, Mar Noguerol, Alicia Prieto, and y Ester Donat
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Enfermedad celiaca ,Niños y adolescentes ,Recomendaciones de seguimiento ,Seguimiento conjunto atención Hospitalaria-atención primaria ,Transición a cuidados de adultos ,Pediatrics ,RJ1-570 - Abstract
Coeliac disease is a common condition for which the only current treatment is a gluten-free diet. Adherence to this diet is not always easy and is associated with a reduction in quality of life for the patient and their family. Non-adherence is associated with complications of varying severity. The lack of control at the outpatient care level in a high percentage of these patients evinces the need to improve follow-up protocols and the approach to care delivery with coordination of paediatric gastroenterology units (PGU) and primary care paediatricians. With this aim in mind, the present document was developed by consensus to offer a set of recommendations adapted to our region, based on the recent recommendations published by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), and with participation of the pertinent scientific societies, including those concerning the adult population, for the management and follow-up of adolescents and the transition to adult care. Resumen: La enfermedad celíaca es una patología frecuente y cuyo único tratamiento en el momento actual es la dieta sin gluten. El seguimiento de esta dieta no siempre es fácil e implica limitaciones en la calidad de vida del paciente y su familia. La no adherencia se asociaría a complicaciones de distinta gravedad. La falta de control de estos pacientes en consultas en un alto porcentaje de casos plantea la necesidad de mejorar los protocolos de seguimiento y de abordarlos de forma coordinada entre las Unidades de Gastroenterología Pediátrica (UGP) y los pediatras de Atención Primaria. Con ese objetivo se han consensuado en este documento, basándose en las recomendaciones recientemente publicadas por la Sociedad Europea de Gastroenterología, Hepatología y Nutrición Pediátrica (ESPGHAN), un conjunto de recomendaciones adaptadas a nuestro entorno y contando con la participación de las Sociedades Científicas implicadas, incluyendo a las Sociedades de adultos para el abordaje del seguimiento del adolescente y de la transición de cuidados a los profesionales de adultos.
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- 2024
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35. Measurement of energy resolution with the NEXT-White silicon photomultipliers
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The NEXT collaboration, T. Contreras, B. Palmeiro, H. Almazán, A. Para, G. Martínez-Lema, R. Guenette, C. Adams, V. Álvarez, B. Aparicio, A. I. Aranburu, L. Arazi, I. J. Arnquist, F. Auria-Luna, S. Ayet, C. D. R. Azevedo, K. Bailey, F. Ballester, M. del Barrio-Torregrosa, A. Bayo, J. M. Benlloch-Rodríguez, F. I. G. M. Borges, A. Brodolin, N. Byrnes, S. Cárcel, A. Castillo, S. Cebrián, E. Church, L. Cid, C. A. N. Conde, F. P. Cossío, E. Dey, G. Díaz, T. Dickel, C. Echevarria, M. Elorza, J. Escada, R. Esteve, R. Felkai, L. M. P. Fernandes, P. Ferrario, A. L. Ferreira, F. W. Foss, Z. Freixa, J. García-Barrena, J. J. Gómez-Cadenas, R. González, J. W. R. Grocott, J. Hauptman, C. A. O. Henriques, J. A. Hernando Morata, P. Herrero-Gómez, V. Herrero, C. Hervés Carrete, Y. Ifergan, B. J. P. Jones, F. Kellerer, L. Larizgoitia, A. Larumbe, P. Lebrun, F. Lopez, N. López-March, R. Madigan, R. D. P. Mano, A. P. Marques, J. Martín-Albo, M. Martínez-Vara, R. L. Miller, K. Mistry, J. Molina-Canteras, F. Monrabal, C. M. B. Monteiro, F. J. Mora, K. E. Navarro, P. Novella, A. Nuñez, D. R. Nygren, E. Oblak, J. Palacio, I. Parmaksiz, A. Pazos, J. Pelegrin, M. Pérez Maneiro, M. Querol, A. B. Redwine, J. Renner, I. Rivilla, C. Rogero, L. Rogers, B. Romeo, C. Romo-Luque, F. P. Santos, J. M. F. dos Santos, M. Seemann, I. Shomroni, P. A. O. C. Silva, A. Simón, S. R. Soleti, M. Sorel, J. Soto-Oton, J. M. R. Teixeira, S. Teruel-Pardo, J. F. Toledo, C. Tonnelé, J. Torrent, A. Trettin, A. Usón, P. R. G. Valle, J. F. C. A. Veloso, J. Waiton, and A. Yubero-Navarro
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Dark Matter and Double Beta Decay (experiments) ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract The NEXT-White detector, a high-pressure gaseous xenon time projection chamber, demonstrated the excellence of this technology for future neutrinoless double beta decay searches using photomultiplier tubes (PMTs) to measure energy and silicon photomultipliers (SiPMs) to extract topology information. This analysis uses 83m Kr data from the NEXT-White detector to measure and understand the energy resolution that can be obtained with the SiPMs, rather than with PMTs. The energy resolution obtained of (10.9 ± 0.6)%, full-width half-maximum, is slightly larger than predicted based on the photon statistics resulting from very low light detection coverage of the SiPM plane in the NEXT-White detector. The difference in the predicted and measured resolution is attributed to poor corrections, which are expected to be improved with larger statistics. Furthermore, the noise of the SiPMs is shown to not be a dominant factor in the energy resolution and may be negligible when noise subtraction is applied appropriately, for high-energy events or larger SiPM coverage detectors. These results, which are extrapolated to estimate the response of large coverage SiPM planes, are promising for the development of future, SiPM-only, readout planes that can offer imaging and achieve similar energy resolution to that previously demonstrated with PMTs.
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- 2024
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36. Is it really over when it is over? physical, mental and emotional health status of long-term breast cancer survivors compared to healthy matched controls
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Álvarez-Salvago, Francisco, Gutiérrez-García, Palmira, Molina-García, Cristina, Atienzar-Aroca, Sandra, Jiménez-García, José Daniel, Aibar-Almazán, Agustín, Martínez-Amat, Antonio, and Pujol-Fuentes, Clara
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- 2024
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37. Demonstration of neutrinoless double beta decay searches in gaseous xenon with NEXT
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NEXT Collaboration, Novella, P., Sorel, M., Usón, A., Adams, C., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Auria-Luna, F., Ayet, S., Azevedo, C. D. R., Bailey, K., Ballester, F., del Barrio-Torregrosa, M., Bayo, A., Benlloch-Rodríguez, J. M., Borges, F. I. G. M., Bounasser, S., Byrnes, N., Cárcel, S., Carrión, J. V., Cebrián, S., Church, E., Cid, L., Conde, C. A. N., Contreras, T., Cossío, F. P., Dey, E., Díaz, G., Dickel, T., Elorza, M., Escada, J., Esteve, R., Fahs, A., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Foss, F. W., Freitas, E. D. C., Freixa, Z., Generowicz, J., Goldschmidt, A., Gómez-Cadenas, J. J., González, R., Grocott, J., Guenette, R., Haefner, J., Hafidi, K., Hauptman, J., Henriques, C. A. O., Morata, J. A. Hernando, Herrero-Gómez, P., Herrero, V., Carrete, C. Hervés, Ho, J., Ho, P., Ifergan, Y., Jones, B. J. P., Labarga, L., Larizgoitia, L., Larumbe, A., Lebrun, P., Lopez, F., Gutierrez, D. Lopez, López-March, N., Madigan, R., Mano, R. D. P., Marques, A. P., Martín-Albo, J., Martínez-Lema, G., Martínez-Vara, M., Meziani, Z. E., Miller, R. L., Mistry, K., Molina-Canteras, J., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Vidal, J. Muñoz, Navarro, K. E., Nuñez, A., Nygren, D. R., Oblak, E., Odriozola-Gimeno, M., Palacio, J., Palmeiro, B., Para, A., Parmaksiz, I., Pelegrin, J., Maneiro, M. Pérez, Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rodríguez, J., Rogero, C., Rogers, L., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Simón, A., Soleti, S. R., Stanford, C., Teixeira, J. M. R., Toledo, J. F., Torrent, J., Veloso, J. F. C. A., Vuong, T. T., Waiton, J., and White, J. T.
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Nuclear Experiment ,High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
The NEXT experiment aims at the sensitive search of the neutrinoless double beta decay in $^{136}$Xe, using high-pressure gas electroluminescent time projection chambers. The NEXT-White detector is the first radiopure demonstrator of this technology, operated in the Laboratorio Subterr\'aneo de Canfranc. Achieving an energy resolution of 1% FWHM at 2.6 MeV and further background rejection by means of the topology of the reconstructed tracks, NEXT-White has been exploited beyond its original goals in order to perform a neutrinoless double beta decay search. The analysis considers the combination of 271.6 days of $^{136}$Xe-enriched data and 208.9 days of $^{136}$Xe-depleted data. A detailed background modeling and measurement has been developed, ensuring the time stability of the radiogenic and cosmogenic contributions across both data samples. Limits to the neutrinoless mode are obtained in two alternative analyses: a background-model-dependent approach and a novel direct background-subtraction technique, offering results with small dependence on the background model assumptions. With a fiducial mass of only 3.50$\pm$0.01 kg of $^{136}$Xe-enriched xenon, 90% C.L. lower limits to the neutrinoless double beta decay are found in the T$_{1/2}^{0\nu}>5.5\times10^{23}-1.3\times10^{24}$ yr range, depending on the method. The presented techniques stand as a proof-of-concept for the searches to be implemented with larger NEXT detectors.
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- 2023
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38. NEXT-CRAB-0: A High Pressure Gaseous Xenon Time Projection Chamber with a Direct VUV Camera Based Readout
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NEXT Collaboration, Byrnes, N. K., Parmaksiz, I., Adams, C., Asaadi, J., Baeza-Rubio, J, Bailey, K., Church, E., González-Díaz, D., Higley, A., Jones, B. J. P., Mistry, K., Moya, I. A., Nygren, D. R., Oyedele, P., Rogers, L., Stogsdill, K., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Ayet, S., Azevedo, C. D. R., Ballester, F., del Barrio-Torregrosa, M., Bayo, A., Benlloch-Rodríguez, J. M., Borges, F. I. G. M., Bounasser, S., Cárcel, S., Carrión, J. V., Cebrián, S., Cid, L., Conde, C. A. N., Contreras, T., Cossío, F. P., Dey, E., Díaz, G., Dickel, T., Elorza, M., Escada, J., Esteve, R., Fahs, A., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Foss, F. W., Freitas, E. D. C., Freixa, Z., Generowicz, J., Goldschmidt, A., Gómez-Cadenas, J. J., González, R., Grocott, J., Guenette, R., Haefner, J., Hafidi, K., Hauptman, J., Henriques, C. A. O., Morata, J. A. Hernando, Herrero-Gómez, P., Herrero, V., Carrete, C. Hervés, Ho, J., Ho, P., Ifergan, Y., Labarga, L., Larizgoitia, L., Lebrun, P., Lopez, F, Gutierrez, D. Lopez, López-March, N., Madigan, R., Mano, R. D. P., Marques, A. P., Martín-Albo, J., Martínez-Lema, G., Martínez-Vara, M., Meziani, Z. E., Miller, R. L., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Vidal, J. Muñoz, Navarro, K. E., Novella, P., Nuñez, A., Oblak, E., Odriozola-Gimeno, M., Palacio, J., Palmeiro, B., Para, A., Pelegrin, J, Maneiro, M. Pérez, Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rodríguez, J., Rogero, C., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Simón, A., Soleti, S. R., Sorel, M., Stanford, C., Teixeira, J. M. R., Toledo, J. F., Torrent, J., Usón, A., Veloso, J. F. C. A., Vuong, T. T., Waiton, J., and White, J. T.
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Physics - Instrumentation and Detectors - Abstract
The search for neutrinoless double beta decay ($0\nu\beta\beta$) remains one of the most compelling experimental avenues for the discovery in the neutrino sector. Electroluminescent gas-phase time projection chambers are well suited to $0\nu\beta\beta$ searches due to their intrinsically precise energy resolution and topological event identification capabilities. Scalability to ton- and multi-ton masses requires readout of large-area electroluminescent regions with fine spatial resolution, low radiogenic backgrounds, and a scalable data acquisition system. This paper presents a detector prototype that records event topology in an electroluminescent xenon gas TPC via VUV image-intensified cameras. This enables an extendable readout of large tracking planes with commercial devices that reside almost entirely outside of the active medium.Following further development in intermediate scale demonstrators, this technique may represent a novel and enlargeable method for topological event imaging in $0\nu\beta\beta$., Comment: 30 Pages, 22 figures, Updated to match current JINST submission
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- 2023
39. A Compact Dication Source for Ba$^{2+}$ Tagging and Heavy Metal Ion Sensor Development
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Navarro, K. E., Jones, B. J. P., Baeza-Rubio, J., Boyd, M., Denisenko, A. A., Foss, F. W., Giri, S., Miller, R., Nygren, D. R., Tiscareno, M. R., Samaniego, F. J., Stogsdill, K., Adams, C., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Ayet, S., Azevedo, C. D. R., Bailey, K., Ballester, F., Benlloch-Rodríguez, J. M., Borges, F. I. G. M., Bounasser, S., Byrnes, N., Cárcel, S., Carrión, J. V., Cebrián, S., Church, E., Conde, C. A. N., Contreras, T., Cossío, F. P., Dey, E., Díaz, G., Dickel, T., Escada, J., Esteve, R., Fahs, A., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Freitas, E. D. C., Freixa, Z., Generowicz, J., Goldschmidt, A., Gómez-Cadenas, J. J., González, R., Grocott, J., Guenette, R., Haefner, J., Hafidi, K., Hauptman, J., Henriques, C. A. O., Morata, J. A. Hernando, Herrero-Gómez, P., Herrero, V., Carrete, C. Hervés, Ho, J., Ho, P., Ifergan, Y., Labarga, L., Larizgoitia, L., Lebrun, P., Gutierrez, D. Lopez, López-March, N., Madigan, R., Mano, R. D. P., Marques, A. P., Martín-Albo, J., Martínez-Lema, G., Martínez-Vara, M., Meziani, Z. E., Mistry, K., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Vidal, J. Muñoz, Novella, P., Nuñez, A., Oblak, E., Odriozola-Gimeno, M., Palmeiro, B., Para, A., Pelegrín, J., Maneiro, M. Pérez, Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rodríguez, J., Rogero, C., Rogers, L., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Simón, A., Sorel, M., Stanford, C., Teixeira, J. M. R., Toledo, J. F., Torrent, J., Usón, A., Veloso, J. F. C. A., Vuong, T. T., Waiton, J., and White, J. T.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
We present a tunable metal ion beam that delivers controllable ion currents in the picoamp range for testing of dry-phase ion sensors. Ion beams are formed by sequential atomic evaporation and single or multiple electron impact ionization, followed by acceleration into a sensing region. Controllability of the ionic charge state is achieved through tuning of electrode potentials that influence the retention time in the ionization region. Barium, lead, and cobalt samples have been used to test the system, with ion currents identified and quantified using a quadrupole mass analyzer. Realization of a clean $\mathrm{Ba^{2+}}$ ion beam within a bench-top system represents an important technical advance toward the development and characterization of barium tagging systems for neutrinoless double beta decay searches in xenon gas. This system also provides a testbed for investigation of novel ion sensing methodologies for environmental assay applications, with dication beams of Pb$^{2+}$ and Cd$^{2+}$ also demonstrated for this purpose.
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- 2023
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40. Influencia de la seguridad y la confianza como antecedentes de la aceptación y uso del comercio electrónico
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Salas-Rubio, María Inés and Almazán, Demian Ábrego
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- 2024
41. Beyond support: exploring the dynamic and static biomechanical changes induced by preventive ankle taping: a novel cross-sectional study
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María Bravo-Aguilar, Vanesa Abuín-Porras, María Blanco-Morales, Carlos Romero Morales, Jaime Almazán-Polo, Jorge Hugo Villafañe, and Lorena Canosa-Carro
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Ankle ,Taping ,Balance ,Sport injury ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Introduction In sports, 80% of all ankle injuries are sprains of the external compartment. Functional bandages are usually used preventively, specially in individuals with a history of lateral ankle injuries. To this day, the actual benefits of such taping remain unknown as important modifications are introduced in the ankle biomechanics. Objective The aim of the present study is to describe the biomechanical processes underlying these effects, such as modification during stance times, balance, contact surface and maximum and average pressures in the rearfoot, forefoot and midfoot, using a sprain preventive taping for the external ankle compartment. Methods An observational, analytic, cross-sectional study was designed. Data from static and dynamic plantar pressures with a pressure platform and balance data assessed with the Y Balance Test (YBT) were analysed in 50 participants (age = 21.00 ± 2.34 years, weight = 71.11 ± 13.12 kg, height = 1.75 ± 00.9 m, BMI = 22.94 ± 2.50 kg/m2, foot size = 41.60 ± 3.00) with and without preventive functional taping for lateral ankle sprain (LAS). Results A statistically significant decrease in YBT was observed in the taped participants toward anterior (p = 0.001) and posterolateral (p = 0.005) motion. On the static measures at the pressure platform, an increase in peak pressure at the midfoot (p = 0.001), a decrease in the maximum pressure in the forefoot (p = 0.003) and a decrease in the contact surface in the rearfoot (p = 0.003) were recorded. Dynamic measures at the pressure platform analysis showed a statistically significant decrease in contact surface at the rearfoot (p = 0.001), an increase in mean pressure in both the midfoot (p = 0.044) and forefoot (p = 0.001) and a significant decrease in velocity in the forefoot (p = 0.003). Conclusions In conclusion, we observed that ankle taping led to increased peak pressures in the midfoot and decreased maximum pressures in the forefoot, indicating a shift in load distribution within the plantar surface. Simultaneously, a significant reduction in the velocity at the forefoot during dynamic tasks suggests that taping may alter natural gait dynamics, potentially affecting movement efficiency and stride characteristics. In addition, the application of ankle taping significantly altered balance, as evidenced by a decrease of YBT scores anterior and posterolateral directions. Prophylactic taping in patients with no prior history of LAS is not recommended.
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- 2025
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42. Tell me y: anticipation of sex discrepancies in cell-free DNA testing due to maternal genetic abnormalities: a case report
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Nuria Balaguer, Emilia Mateu-Brull, Jose Antonio Martínez-Conejero, Ana Cervero, Roser Navarro, Jorge Jiménez-Almazán, and Miguel Milán
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sex discordance ,y-chromosome ,maternal abnormalities ,non-invasive prenatal testing (NIPT) ,cell-free (fetal) DNA ,case-report ,Genetics ,QH426-470 - Abstract
Sex discordance between cell-free DNA (cfDNA) testing and ultrasound examination is rare but can cause significant patient discomfort and uncertainty. Here, we present two clinical cases where a closer examination of raw sequencing data allowed us to anticipate possible discrepancies caused by the insertion of Y-chromosome regions into the maternal genome. We used Illumina’s VeriSeq NIPT Solution v2 and a proprietary bioinformatics pipeline to analyze cfDNA in the maternal bloodstream. Paired-end sequencing data were aligned to the reference genome (hg19). Non-duplicated aligned reads were aggregated into 100-kb bins, adjusted for CG bias, and further aggregated into 5-Mb windows. Z-scores were calculated for autosomes, sex chromosomes, and 5-Mb bins. The two clinical cases were classified as low-risk male fetuses according to the primary statistics (case A: NCVx = 0.3; NCVy = 40.6; native fetal fraction (FFi) = 5.1%, and case B: NCVx = −0.3, NCVy = 40.7, FFi = 10.8%); however, the Y-chromosome-based FF (FFy) was significantly lower than the default FF estimate (FFy ≅ 2% in both cases). Plots of X and Y chromosome Z-scores for each 5-Mb bin, according to genomic position, identified bins with Z-scores significantly higher than those expected for any pregnancy with a male fetus. The genomic coordinates of these bins overlapped with the amelogenin (AMELY) and protein kinase Y-linked (PRKY) genes, respectively. Amplification of these regions in the DNA isolated from the white blood cells fraction confirmed the presence of Y-chromosome insertions in the maternal genome. This study highlights a new source of discrepancy in cfDNA testing due to maternal genomic variations. These findings suggest the need for improvements to current bioinformatics pipelines to identify and exclude possible maternal perturbations from the classification algorithms used for aneuploidy and sex calls.
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- 2025
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43. Caracterización morfológica y fisiológica de aislamientos nativos de Beauveria brongniartii a partir de insectos infectados en campo
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Carlos López Blanco, David Cruz Choque, Jorge Espinoza Almazán, and Juan Javier Quino Luna
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hongos entomopatógenos ,Beauveria brongniartii ,caracterización ,aislamientos ,conidias ,Agriculture (General) ,S1-972 ,Plant culture ,SB1-1110 - Abstract
El hongo Beauveria brongniartii tiene actividad patogénica sobre diversos insectos en el agroecosistema andino. Sin embargo, los estudios en este campo son escasos en el país. El objetivo del estudio fue caracterizar morfológica y fisiológicamente aislamientos nativos del hongo, a partir de insectos infectados en campo, en la Estación Experimental Choquenaira, Viacha - Bolivia. Se colectó insectos parasitados de campo, los cuales se aislaron y caracterizaron bajo criterios morfológicos y fisiológicos en laboratorio. Las variables evaluadas fueron: análisis de aislamientos obtenidos, características morfológicas macroscópicas (crecimiento, aspecto, color, superficie, pigmentación y sinemas) y microscópicas (hifas, conidióforos, fiálides, raquis, conidias) y medidas fisiológicas (crecimiento, conidiación y germinación). Se realizó el análisis descriptivo (caracteres morfológicos) y estadístico (caracteres fisiológicos) bajo el diseño completo al azar, con ANVA, prueba Duncan, desviación estándar (error ≤ 5 %). Se obtuvo cinco aislamientos a partir de los hospederos Phyllophaga sp., Premnotrypes sp (2), Astylus vittaticollis, Notiobia sp. (Bbr1, Bbr2, Bbr3, Bbr4 y Bbr5), denotando su adaptabilidad, su rango y especificidad sobre insectos. El análisis morfológico presento variación y similitud en sus características, perteneciendo los aislados a la especie B. brongniartii. El análisis fisiológico determino diferencias en conidiación, sobresaliendo el Bbr5 (5.95 x 107 c ml-1), y sin diferencias las variables crecimiento radial (TDCR) y germinación, con superioridad no significativa de Bbr2 (39.20 mm y 1.91 mm día-1) y Bbr5 (94.20 %). La investigación realizada aporta resultados positivos ya que al caracterizar los aislamientos nativos de B. brongniartii a partir de insectos infectados, se confirma el potencial de la especie para realizar a futuro la caracterización patogénica en la obtención de cepas promisorias para el control biológico de plagas en la región.
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- 2024
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44. Paisajes con el monte Fuji y el Popocatepetl en el Museo Kaluz de Ciudad de México: «Casi oro, casi ámbar, casi luz. Bienvenida del paisaje mexicano al paisaje japonés»
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David Almazán Tomás
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pintura japonesa ,exposición ,México ,paisaje ,Social sciences and state - Asia (Asian studies only) ,H53 ,Social sciences (General) ,H1-99 - Abstract
El texto recoge la reseña crítica sobre la exposición «Casi oro, casi ámbar, casi luz. Bienvenida del paisaje mexicano al paisaje japonés»celebrada en 2023 en el Museo Kaluz de Ciudad de México. La exposición, realizada por un equipo curatorial especializado en arte mexicano y en arte japonés presentan un diálogo a través del género del paisaje de México y de Japón. La parte japonesa procede de la donación del norteamericano Terry Welch poseedor de una de las mejores colecciones de pintura nipona de los siglo XIX y XX en Hispanoamérica.
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- 2024
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45. A Corpus Study of Brexit Political Discourse: Exploring Modality through Lexical Modals
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Encarnación Almazán Ruiz and Aroa Orrequia-Barea
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modality ,lexical modals ,corpus-assisted discourse studies ,political discourse ,Brexit ,Language and Literature - Abstract
This paper aims to analyse the lexical modals used in the political speeches given by Boris Johnson and Jeremy Corbyn during the final months of the Brexit process. This study explores whether lexical choice shows the politicians’ commitment to their constituents, particularly to determine which lexical modals each politician uses and which semantic implication(s) these modals convey. The study is descriptive-interpretative and uses the corpus-assisted discourse studies approach. It contributes to research on modality in the English language by examining parts of speech other than (semi)auxiliary modal verbs. As the corpus analysis shows, lexical modals are a prominent resource employed by politicians to present facts to their audience.
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- 2024
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46. Dispersion of Activation in Single‐Beat Global Maps During Programmed Ventricular Stimulation Identifies Infarct‐Related Ventricular Tachycardia Isthmus Sites
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Andrés Redondo‐Rodríguez, Alba Ramos‐Prada, Jorge G. Quintanilla, David Calvo, Javier Sánchez‐González, Daniel Enríquez‐Vázquez, Manuel Marina‐Breysse, Jose Manuel Alfonso‐Almazán, Juan José González‐Ferrer, Victoria Cañadas‐Godoy, Ricardo Salgado‐Aranda, Carlos A. Morillo, Julián Pérez‐Villacastín, Nicasio Pérez‐Castellano, and David Filgueiras‐Rama
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dispersion of activation ,electroanatomical mapping ,magnetic resonance imaging ,programmed ventricular stimulation ,single‐beat mapping ,ventricular arrhythmia ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Electrophysiological characterization of ventricular tachycardia (VT) isthmus sites is complex and time‐consuming. We aimed at developing and validating a global mapping strategy during programmed ventricular stimulation (PVS) to reveal the underlying electrophysiological properties of the infarct‐related substrate and to enable identification of highly heterogeneous activation sites associated with protected VT isthmus sites. Methods and Results Experimental study that included 22 pigs with established myocardial infarction undergoing in vivo characterization of the anatomical and functional myocardial substrate associated with potential arrhythmogenicity. High‐density sequential activation maps during ventricular pacing and VT were compared with single‐beat maps using a 64‐pole basket catheter positioned in the left ventricle. Further analyses were performed using a novel local activation time‐dispersion score to identify regional activation time heterogeneities on both baseline drive pacing and each of the extrastimuli of the PVS protocol. Basket catheter splines covered a median of 81.2% of the endocardial surface of the left ventricle. Basket‐catheter‐derived single‐beat activation maps (N=16) during pacing showed a linear relationship with high‐density sequential activation maps. Induction of ventricular arrhythmias was associated with higher local activation time‐dispersion score values on single‐beat global maps during PVS (N=6, 46 arrhythmia induction attempts). Single‐beat‐derived local activation time‐dispersion score maps during successive coupled extrastimuli of the PVS showed a progressive increase in the predictive performance to identify monomorphic VT isthmus sites within the scar region (area under the curve = 0.779 in S2, area under the curve = 0.859 in S4; N=7). Conclusions Sixty‐four‐pole‐derived single‐beat local activation time‐dispersion score global maps during PVS identify infarct‐related endocardial regions with highly heterogeneous activation times that are associated with protected VT isthmus sites.
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- 2024
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47. The ESO's Extremely Large Telescope Working Groups
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Padovani, Paolo, Cirasuolo, Michele, van der Burg, Remco, Cantalloube, Faustine, George, Elizabeth, Kasper, Markus, Leschinski, Kieran, Martins, Carlos, Milli, Julien, Möhler, Sabine, Neeser, Mark, Neichel, Benoit, Otarola, Angel, Sánchez-Janssen, Rubén, Serra, Benoit, Smette, Alain, Valenti, Elena, Verinaud, Christophe, Vernet, Joël, Absil, Olivier, Agapito, Guido, Andersen, Morten, Arcidiacono, Carmelo, Arko, Matej, Baudoz, Pierre, Beltramo-Martin, Olivier, Biancalani, Enrico, Bierwirth, Thomas, Burtscher, Leonard, Carlà, Giulia, Castro-Almazán, Julio A., Cheffot, Anne-Laure, Coccato, Lodovico, Correia, Carlos, Fetick, Romain, Fiorentino, Giuliana, Fusco, Thierry, García-Lorenzo, Begoña, Fusillo, Nicola Gentile, Gonzalez, Oscar, Grazian, Andrea, Gullieuszik, Marco, Hainaut, Olivier, Ivanov, Valentin, Kaasinen, Melanie, Kaddad, Darshan, Kamiński, Tomasz, Kausch, Wolfgang, Kerber, Florian, Kimeswenger, Stefan, Kokotanekova, Rosita, Kuznetsov, Arseniy, Lau, Alexis, Louarn, Miska Le, Lemmel, Frédéric, Liske, Jochen, Curto, Gaspare Lo, Lucsanyi, David, Lundin, Lars, Noll, Stefan, Oberti, Sylvain, Osborn, James, Masciadri, Elena, Milaković, Dinko, Murphy, Michael T., Pedichini, Fernando, Santaella, Miguel Pereira, Piazzesi, Roberto, López, Javier Piqueras, Plantet, Cédric, Prod'homme, Thibaut, Przybilla, Norbert, Puech, Mathieu, Reid, Derryck T., Reiners, Ansgar, Rijnenberg, Rutger, Rodrigues, Myriam, Rossi, Fabio, Routledge, Laurence, Smit, Hans, Tecza, Mathias, Thatte, Niranjan, van Boekel, Roy, Verma, Aprajita, and Vigan, Arthur
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Since 2005 ESO has been working with its community and industry to develop an extremely large optical/infrared telescope. ESO's Extremely Large Telescope, or ELT for short, is a revolutionary ground-based telescope that will have a 39-metre main mirror and will be the largest visible and infrared light telescope in the world. To address specific topics that are needed for the science operations and calibrations of the telescope, thirteen specific working groups were created to coordinate the effort between ESO, the instrument consortia, and the wider community. We describe here the goals of these working groups as well as their achievements so far., Comment: 8 pages, 4 figures
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- 2023
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48. Pereskia sacharosa Griseb. (Cactaceae) Prevents Lipopolysaccharide-Induced Neuroinflammation in Rodents via Down-Regulating TLR4/CD14 Pathway and GABAA γ2 Activity
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María Fernanda Prado-Fernández, Víctor Manuel Magdaleno-Madrigal, Emmanuel Cabañas-García, Samuel Mucio-Ramírez, Salvador Almazán-Alvarado, Eugenio Pérez-Molphe-Balch, Yenny Adriana Gómez-Aguirre, and Edith Sánchez-Jaramillo
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phenolic compounds ,LPS ,theta oscillation ,GABAA γ2 ,c-fos ,CD14 mRNA ,Biology (General) ,QH301-705.5 - Abstract
Pereskia sacharosa Griseb. is a plant used in traditional herbal medicine to treat inflammation. We analyzed the phenolic content of P. sacharosa leaves (EEPs) by liquid chromatography–tandem mass spectrometry (LC-MS/MS) and investigated the anti-inflammatory properties of EEPs and its flavonoid fraction (F10) in animal models subjected to acute neuroinflammation induced by bacterial lipopolysaccharide (LPS). Coronal brain sections of C57BL/6JN male mice or Wistar male rats administered with EEPs or F10 before LPS were subjected to in situ hybridization to determine c-fos and CD14 mRNA levels in the hypothalamus or GABAA γ2 mRNA levels in the hippocampus. Theta oscillations were recorded every 6 h in the hippocampus of Wistar rats. In total, five flavonoids and eight phenolic acids were identified and quantified in P. sacharosa leaves. Either EEPs or F10 crossed the blood–brain barrier (BBB) into the brain and reduced the mRNA expression of c-fos, CD14, and GABAA γ2. A decrease in theta oscillation was observed in the hippocampus of the LPS group, while the F10 + LPS group overrode the LPS effect on theta activity. We conclude that the bioactive compounds of P. sacharosa reduce the central response to inflammation, allowing the early return of ambulatory activity and well-being of the animal.
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- 2024
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49. Reflectance and fluorescence characteristics of PTFE coated with TPB at visible, UV, and VUV as a function of thickness
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Haefner, J., Fahs, A., Ho, J., Stanford, C., Guenette, R., Adams, C., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., Arazi, L., Arnquist, I. J., Auria-Luna, F., Ayet, S., Azevedo, C. D. R., Bailey, K., Ballester, F., Benlloch-Rodríguez, J. M., Borges, F. I. G. M., Bounasser, S., Byrnes, N., Cárcel, S., Carrión, J. V., Cebrián, S., Church, E., Conde, C. A. N., Contreras, T., Cossío, F. P., Denisenko, A. A., Dey, E., Díaz, G., Dickel, T., Escada, J., Esteve, R., Felkai, R., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Foss, F. W., Freitas, E. D. C., Freixa, Z., Generowicz, J., Goldschmidt, A., Gómez-Cadenas, J. J., González, R., Grocott, J., Hafidi, K., Hauptman, J., Henriques, C. A. O., Morata, J. A. Hernando, Herrero-Gómez, P., Herrero, V., Ho, P., Ifergan, Y., Jones, B. J. P., Kekic, M., Labarga, L., Larizgoitia, L., Lebrun, P., Gutierrez, D. Lopez, López-March, N., Madigan, R., Mano, R. D. P., Martín-Albo, J., Martínez-Lema, G., Martínez-Vara, M., Marques, A. P., Meziani, Z. E., Miller, R., Mistry, K., Molina-Canteras, J., Monrabal, F., Monteiro, C. M. B., Mora, F. J., Vidal, J. Muñoz, Navarro, K., Novella, P., Nuñez, A., Nygren, D. R., Oblak, E., Odriozola-Gimeno, M., Palmeiro, B., Para, A., Querol, M., Redwine, A. B., Renner, J., Rivilla, I., Rodríguez, J., Rogero, C., Rogers, L., Romeo, B., Romo-Luque, C., Santos, F. P., Santos, J. M. F. dos, Simón, A., Sorel, M., Teixeira, J. M. R., Toledo, J. F., Torrent, J., Usón, A., Veloso, J. F. C. A., Vuong, T. T., and Waiton, J.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Physics - Optics - Abstract
Polytetrafluoroethylene (PTFE) is an excellent diffuse reflector widely used in light collection systems for particle physics experiments. In noble element systems, it is often coated with tetraphenyl butadiene (TPB) to allow detection of vacuum ultraviolet scintillation light. In this work this dependence is investigated for PTFE coated with TPB in air for light of wavelengths of 200~nm, 260~nm, and 450~nm. The results show that TPB-coated PTFE has a reflectance of approximately 92\% for thicknesses ranging from 5~mm to 10~mm at 450~nm, with negligible variation as a function of thickness within this range. A cross-check of these results using an argon chamber supports the conclusion that the change in thickness from 5~mm to 10~mm does not affect significantly the light response at 128~nm. Our results indicate that pieces of TPB-coated PTFE thinner than the typical 10~mm can be used in particle physics detectors without compromising the light signal.
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- 2022
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50. Stereo neutrino spectrum of 235U fission rejects sterile neutrino hypothesis
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Almazán, H., Bernard, L., Blanchet, A., Bonhomme, A., Buck, C., Chalil, A., Sanchez, P. del Amo, Atmani, I. El, Labit, L., Lhuillier, J. Lamblin A. Letourneau D., Licciardi, M., Lindner, M., Materna, T., Pessard, H., Réal, J. -S., Ricol, J. -S., Roca, C., Rogly, R., Salagnac, T., Savu, V., Schoppmann, S., Soldner, T., Stutz, A., and Vialat, M.
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High Energy Physics - Experiment - Abstract
Anomalies in past neutrino measurements have led to the discovery that these particles have non-zero mass and oscillate between their three flavors when they propagate. In the 2010's, similar anomalies observed in the antineutrino spectra emitted by nuclear reactors have triggered the hypothesis of the existence of a supplementary neutrino state that would be sterile i.e. not interacting via the weak interaction. The STEREO experiment was designed to study this scientific case that would potentially extend the Standard Model of Particle Physics. Here we present a complete study based on our full set of data with significantly improved sensitivity. Installed at the ILL (Institut Laue Langevin) research reactor, STEREO has accurately measured the antineutrino energy spectrum associated to the fission of 235U. This measurement confirms the anomalies whereas, thanks to the segmentation of the STEREO detector and its very short mean distance to the core (10~m), the same data reject the hypothesis of a light sterile neutrino. Such a direct measurement of the antineutrino energy spectrum suggests instead that biases in the nuclear experimental data used for the predictions are at the origin of the anomalies. Our result supports the neutrino content of the Standard Model and establishes a new reference for the 235U antineutrino energy spectrum. We anticipate that this result will allow to progress towards finer tests of the fundamental properties of neutrinos but also to benchmark models and nuclear data of interest for reactor physics and for observations of astrophysical or geo-neutrinos., Comment: 34 pages, 13 figures. Final version submitted to Nature
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- 2022
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