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23 results on '"Almanza, Diego"'

1. Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin

Author

Mittal, Karuna, Cooper, Garrett W., Lee, Benjamin P., Su, Yongdong, Skinner, Katie T., Shim, Jenny, Jonus, Hunter C., Kim, Won Jun, Doshi, Mihir, Almanza, Diego, Kynnap, Bryan D., Christie, Amanda L., Yang, Xiaoping, Cowley, Glenn S., Leeper, Brittaney A., Morton, Christopher L., Dwivedi, Bhakti, Lawrence, Taylor, Rupji, Manali, Keskula, Paula, Meyer, Stephanie, Clinton, Catherine M., Bhasin, Manoj, Crompton, Brian D., Tseng, Yuen-Yi, Boehm, Jesse S., Ligon, Keith L., Root, David E., Murphy, Andrew J., Weinstock, David M., Gokhale, Prafulla C., Spangle, Jennifer M., Rivera, Miguel N., Mullen, Elizabeth A., Stegmaier, Kimberly, Goldsmith, Kelly C., Hahn, William C., and Hong, Andrew L.

Published
2024
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2. KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition

Author

Binkley, Michael S, Jeon, Young-Jun, Nesselbush, Monica, Moding, Everett J, Nabet, Barzin Y, Almanza, Diego, Kunder, Christian, Stehr, Henning, Yoo, Christopher H, Rhee, Siyeon, Xiang, Michael, Chabon, Jacob J, Hamilton, Emily, Kurtz, David M, Gojenola, Linda, Owen, Susie Grant, Ko, Ryan B, Shin, June Ho, Maxim, Peter G, Lui, Natalie S, Backhus, Leah M, Berry, Mark F, Shrager, Joseph B, Ramchandran, Kavitha J, Padda, Sukhmani K, Das, Millie, Neal, Joel W, Wakelee, Heather A, Alizadeh, Ash A, Loo, Billy W, and Diehn, Maximilian

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Lung, Cancer, Clinical Research, Lung Cancer, Biomarkers, Glutaminase, Humans, Kelch-Like ECH-Associated Protein 1, Lung Neoplasms, Mutation, NF-E2-Related Factor 2, Radiation Tolerance, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Tumor genotyping is not routinely performed in localized non-small cell lung cancer (NSCLC) due to lack of associations of mutations with outcome. Here, we analyze 232 consecutive patients with localized NSCLC and demonstrate that KEAP1 and NFE2L2 mutations are predictive of high rates of local recurrence (LR) after radiotherapy but not surgery. Half of LRs occurred in tumors with KEAP1/NFE2L2 mutations, indicating that they are major molecular drivers of clinical radioresistance. Next, we functionally evaluate KEAP1/NFE2L2 mutations in our radiotherapy cohort and demonstrate that only pathogenic mutations are associated with radioresistance. Furthermore, expression of NFE2L2 target genes does not predict LR, underscoring the utility of tumor genotyping. Finally, we show that glutaminase inhibition preferentially radiosensitizes KEAP1-mutant cells via depletion of glutathione and increased radiation-induced DNA damage. Our findings suggest that genotyping for KEAP1/NFE2L2 mutations could facilitate treatment personalization and provide a potential strategy for overcoming radioresistance conferred by these mutations. SIGNIFICANCE: This study shows that mutations in KEAP1 and NFE2L2 predict for LR after radiotherapy but not surgery in patients with NSCLC. Approximately half of all LRs are associated with these mutations and glutaminase inhibition may allow personalized radiosensitization of KEAP1/NFE2L2-mutant tumors.This article is highlighted in the In This Issue feature, p. 1775.

Published
2020

3. Integrating genomic features for non-invasive early lung cancer detection

Author

Chabon, Jacob J., Hamilton, Emily G., Kurtz, David M., Esfahani, Mohammad S., Moding, Everett J., Stehr, Henning, Schroers-Martin, Joseph, Nabet, Barzin Y., Chen, Binbin, Chaudhuri, Aadel A., Liu, Chih Long, Hui, Angela B., Jin, Michael C., Azad, Tej D., Almanza, Diego, Jeon, Young-Jun, Nesselbush, Monica C., Co Ting Keh, Lyron, Bonilla, Rene F., Yoo, Christopher H., Ko, Ryan B., Chen, Emily L., Merriott, David J., Massion, Pierre P., Mansfield, Aaron S., Jen, Jin, Ren, Hong Z., Lin, Steven H., Costantino, Christina L., Burr, Risa, Tibshirani, Robert, Gambhir, Sanjiv S., Berry, Gerald J., Jensen, Kristin C., West, Robert B., Neal, Joel W., Wakelee, Heather A., Loo, Jr, Billy W., Kunder, Christian A., Leung, Ann N., Lui, Natalie S., Berry, Mark F., Shrager, Joseph B., Nair, Viswam S., Haber, Daniel A., Sequist, Lecia V., Alizadeh, Ash A., and Diehn, Maximilian

Published
2020
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6. Supplementary Figures 1-9 from KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition

Author

Binkley, Michael S., primary, Jeon, Young-Jun, primary, Nesselbush, Monica, primary, Moding, Everett J., primary, Nabet, Barzin Y., primary, Almanza, Diego, primary, Kunder, Christian, primary, Stehr, Henning, primary, Yoo, Christopher H., primary, Rhee, Siyeon, primary, Xiang, Michael, primary, Chabon, Jacob J., primary, Hamilton, Emily, primary, Kurtz, David M., primary, Gojenola, Linda, primary, Owen, Susie Grant, primary, Ko, Ryan B., primary, Shin, June Ho, primary, Maxim, Peter G., primary, Lui, Natalie S., primary, Backhus, Leah M., primary, Berry, Mark F., primary, Shrager, Joseph B., primary, Ramchandran, Kavitha J., primary, Padda, Sukhmani K., primary, Das, Millie, primary, Neal, Joel W., primary, Wakelee, Heather A., primary, Alizadeh, Ash A., primary, Loo, Billy W., primary, and Diehn, Maximilian, primary

Published
2023
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7. Data from KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition

Author

Binkley, Michael S., primary, Jeon, Young-Jun, primary, Nesselbush, Monica, primary, Moding, Everett J., primary, Nabet, Barzin Y., primary, Almanza, Diego, primary, Kunder, Christian, primary, Stehr, Henning, primary, Yoo, Christopher H., primary, Rhee, Siyeon, primary, Xiang, Michael, primary, Chabon, Jacob J., primary, Hamilton, Emily, primary, Kurtz, David M., primary, Gojenola, Linda, primary, Owen, Susie Grant, primary, Ko, Ryan B., primary, Shin, June Ho, primary, Maxim, Peter G., primary, Lui, Natalie S., primary, Backhus, Leah M., primary, Berry, Mark F., primary, Shrager, Joseph B., primary, Ramchandran, Kavitha J., primary, Padda, Sukhmani K., primary, Das, Millie, primary, Neal, Joel W., primary, Wakelee, Heather A., primary, Alizadeh, Ash A., primary, Loo, Billy W., primary, and Diehn, Maximilian, primary

Published
2023
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8. Supplementary Tables S1-S7 from KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition

Author

Binkley, Michael S., primary, Jeon, Young-Jun, primary, Nesselbush, Monica, primary, Moding, Everett J., primary, Nabet, Barzin Y., primary, Almanza, Diego, primary, Kunder, Christian, primary, Stehr, Henning, primary, Yoo, Christopher H., primary, Rhee, Siyeon, primary, Xiang, Michael, primary, Chabon, Jacob J., primary, Hamilton, Emily, primary, Kurtz, David M., primary, Gojenola, Linda, primary, Owen, Susie Grant, primary, Ko, Ryan B., primary, Shin, June Ho, primary, Maxim, Peter G., primary, Lui, Natalie S., primary, Backhus, Leah M., primary, Berry, Mark F., primary, Shrager, Joseph B., primary, Ramchandran, Kavitha J., primary, Padda, Sukhmani K., primary, Das, Millie, primary, Neal, Joel W., primary, Wakelee, Heather A., primary, Alizadeh, Ash A., primary, Loo, Billy W., primary, and Diehn, Maximilian, primary

Published
2023
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9. Table S1 from Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., primary, Rizvi, Hira, primary, Chaudhuri, Aadel A., primary, Wells, Daniel K., primary, Dunphy, Mark P.S., primary, Chabon, Jacob J., primary, Liu, Chih Long, primary, Hui, Angela B., primary, Arbour, Kathryn C., primary, Luo, Jia, primary, Preeshagul, Isabel R., primary, Moding, Everett J., primary, Almanza, Diego, primary, Bonilla, Rene F., primary, Sauter, Jennifer L., primary, Choi, Hyejin, primary, Tenet, Megan, primary, Abu-Akeel, Mohsen, primary, Plodkowski, Andrew J., primary, Perez Johnston, Rocio, primary, Yoo, Christopher H., primary, Ko, Ryan B., primary, Stehr, Henning, primary, Gojenola, Linda, primary, Wakelee, Heather A., primary, Padda, Sukhmani K., primary, Neal, Joel W., primary, Chaft, Jamie E., primary, Kris, Mark G., primary, Rudin, Charles M., primary, Merghoub, Taha, primary, Li, Bob T., primary, Alizadeh, Ash A., primary, and Diehn, Maximilian, primary

Published
2023
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10. Supplementary Tables S2-S7 from Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., primary, Rizvi, Hira, primary, Chaudhuri, Aadel A., primary, Wells, Daniel K., primary, Dunphy, Mark P.S., primary, Chabon, Jacob J., primary, Liu, Chih Long, primary, Hui, Angela B., primary, Arbour, Kathryn C., primary, Luo, Jia, primary, Preeshagul, Isabel R., primary, Moding, Everett J., primary, Almanza, Diego, primary, Bonilla, Rene F., primary, Sauter, Jennifer L., primary, Choi, Hyejin, primary, Tenet, Megan, primary, Abu-Akeel, Mohsen, primary, Plodkowski, Andrew J., primary, Perez Johnston, Rocio, primary, Yoo, Christopher H., primary, Ko, Ryan B., primary, Stehr, Henning, primary, Gojenola, Linda, primary, Wakelee, Heather A., primary, Padda, Sukhmani K., primary, Neal, Joel W., primary, Chaft, Jamie E., primary, Kris, Mark G., primary, Rudin, Charles M., primary, Merghoub, Taha, primary, Li, Bob T., primary, Alizadeh, Ash A., primary, and Diehn, Maximilian, primary

Published
2023
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11. Supplementary Data from Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., primary, Rizvi, Hira, primary, Chaudhuri, Aadel A., primary, Wells, Daniel K., primary, Dunphy, Mark P.S., primary, Chabon, Jacob J., primary, Liu, Chih Long, primary, Hui, Angela B., primary, Arbour, Kathryn C., primary, Luo, Jia, primary, Preeshagul, Isabel R., primary, Moding, Everett J., primary, Almanza, Diego, primary, Bonilla, Rene F., primary, Sauter, Jennifer L., primary, Choi, Hyejin, primary, Tenet, Megan, primary, Abu-Akeel, Mohsen, primary, Plodkowski, Andrew J., primary, Perez Johnston, Rocio, primary, Yoo, Christopher H., primary, Ko, Ryan B., primary, Stehr, Henning, primary, Gojenola, Linda, primary, Wakelee, Heather A., primary, Padda, Sukhmani K., primary, Neal, Joel W., primary, Chaft, Jamie E., primary, Kris, Mark G., primary, Rudin, Charles M., primary, Merghoub, Taha, primary, Li, Bob T., primary, Alizadeh, Ash A., primary, and Diehn, Maximilian, primary

Published
2023
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13. Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

Author

Mittal, Karuna, primary, Lee, Benjamin P., additional, Cooper, Garrett W., additional, Shim, Jenny, additional, Jonus, Hunter C., additional, Kim, Won Jun, additional, Doshi, Mihir, additional, Almanza, Diego, additional, Kynnap, Bryan D., additional, Christie, Amanda L., additional, Yang, Xiaoping, additional, Cowley, Glenn S., additional, Leeper, Brittaney A., additional, Morton, Christopher L., additional, Dwivedi, Bhakti, additional, Lawrence, Taylor, additional, Rupji, Manali, additional, Keskula, Paula, additional, Meyer, Stephanie, additional, Clinton, Catherine M., additional, Bhasin, Manoj, additional, Crompton, Brian D., additional, Tseng, Yuen-Yi, additional, Boehm, Jesse S., additional, Ligon, Keith L., additional, Root, David E., additional, Murphy, Andrew J., additional, Weinstock, David M., additional, Gokhale, Prafulla C., additional, Spangle, Jennifer M., additional, Rivera, Miguel N., additional, Mullen, Elizabeth A., additional, Stegmaier, Kimberly, additional, Goldsmith, Kelly C., additional, Hahn, William C., additional, and Hong, Andrew L., additional

Published
2022
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14. Abstract PO-059: Investigating gene expression profiles associated with clinical radiation resistance in KEAP1/NFE2L2 wildtype lung cancer

Author

Binkley, Michael S., primary, Jeon, Young-Jun, additional, Nesselbush, Monica, additional, Moding, Everett J., additional, Nabet, Barzin, additional, Almanza, Diego, additional, Yoo, Christopher, additional, Kurtz, David M., additional, Owen, Susie Grant, additional, Backhus, Leah M., additional, Berry, Mark F., additional, Shrager, Joseph B., additional, Ramchandran, Kavitha J., additional, Padda, Sukhmani K., additional, Das, Millie, additional, Neal, Joel W., additional, Wakelee, Heather A., additional, Alizadeh, Ash A., additional, Loo, Billy W., additional, and Diehn, Maximilian, additional

Published
2021
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15. Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition

Author

Nabet, Barzin Y., primary, Esfahani, Mohammad S., additional, Moding, Everett J., additional, Hamilton, Emily G., additional, Chabon, Jacob J., additional, Rizvi, Hira, additional, Steen, Chloe B., additional, Chaudhuri, Aadel A., additional, Liu, Chih Long, additional, Hui, Angela B., additional, Almanza, Diego, additional, Stehr, Henning, additional, Gojenola, Linda, additional, Bonilla, Rene F., additional, Jin, Michael C., additional, Jeon, Young-Jun, additional, Tseng, Diane, additional, Liu, Cailian, additional, Merghoub, Taha, additional, Neal, Joel W., additional, Wakelee, Heather A., additional, Padda, Sukhmani K., additional, Ramchandran, Kavitha J., additional, Das, Millie, additional, Plodkowski, Andrew J., additional, Yoo, Christopher, additional, Chen, Emily L., additional, Ko, Ryan B., additional, Newman, Aaron M., additional, Hellmann, Matthew D., additional, Alizadeh, Ash A., additional, and Diehn, Maximilian, additional

Published
2020
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16. Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., additional, Rizvi, Hira, additional, Chaudhuri, Aadel A., additional, Wells, Daniel K., additional, Dunphy, Mark P.S., additional, Chabon, Jacob J., additional, Liu, Chih Long, additional, Hui, Angela B., additional, Arbour, Kathryn C., additional, Luo, Jia, additional, Preeshagul, Isabel R., additional, Moding, Everett J., additional, Almanza, Diego, additional, Bonilla, Rene F., additional, Sauter, Jennifer L., additional, Choi, Hyejin, additional, Tenet, Megan, additional, Abu-Akeel, Mohsen, additional, Plodkowski, Andrew J., additional, Perez Johnston, Rocio, additional, Yoo, Christopher H., additional, Ko, Ryan B., additional, Stehr, Henning, additional, Gojenola, Linda, additional, Wakelee, Heather A., additional, Padda, Sukhmani K., additional, Neal, Joel W., additional, Chaft, Jamie E., additional, Kris, Mark G., additional, Rudin, Charles M., additional, Merghoub, Taha, additional, Li, Bob T., additional, Alizadeh, Ash A., additional, and Diehn, Maximilian, additional

Published
2020
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17. KEAP1/NFE2L2 mutations to predict local recurrence after radiotherapy but not surgery in localized non-small cell lung cancer.

Author

Binkley, Michael S, primary, Jeon, Young-Jun, additional, Nesselbush, Monica, additional, Moding, Everett J, additional, Nabet, Barzin, additional, Almanza, Diego S, additional, Yoo, Christopher, additional, Kurtz, David Matthew, additional, Owen, Susie Grant, additional, Backhus, Leah Monique, additional, Berry, Mark F., additional, Shrager, Joseph B, additional, Ramchandran, Kavitha, additional, Padda, Sukhmani Kaur, additional, Das, Millie, additional, Neal, Joel W., additional, Wakelee, Heather A., additional, Alizadeh, Ash A., additional, Loo, Billy W., additional, and Diehn, Maximilian, additional

Published
2020
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18. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Author

Sulahian, Rita, primary, Kwon, Jason J., additional, Walsh, Katherine H., additional, Pailler, Emma, additional, Bosse, Timothy L., additional, Thaker, Maneesha, additional, Almanza, Diego, additional, Dempster, Joshua M., additional, Pan, Joshua, additional, Piccioni, Federica, additional, Dumont, Nancy, additional, Gonzalez, Alfredo, additional, Rennhack, Jonathan, additional, Nabet, Behnam, additional, Bachman, John A., additional, Goodale, Amy, additional, Lee, Yenarae, additional, Bagul, Mukta, additional, Liao, Rosy, additional, Navarro, Adrija, additional, Yuan, Tina L., additional, Ng, Raymond W.S., additional, Raghavan, Srivatsan, additional, Gray, Nathanael S., additional, Tsherniak, Aviad, additional, Vazquez, Francisca, additional, Root, David E., additional, Firestone, Ari J., additional, Settleman, Jeff, additional, Hahn, William C., additional, and Aguirre, Andrew J., additional

Published
2019
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23. Characterization of activated carbon synthesized at low temperature from cocoa shell (Theobroma cacao) for adsorbing amoxicillin.

Author

Tejada, Candelaria N., Almanza, Diego, Villabona, Angel, Colpas, Fredy, and Granados, Clemente

Subjects
*ACTIVATED carbon, *LOW temperatures, *CACAO, *AMOXICILLIN, *ZINC chloride, *X-ray diffraction, *AQUEOUS solutions
Abstract

The aim of this research was synthesize and characterize activated carbon obtained at low temperature from cocoa peel (Theobroma cacao), modified with zinc chloride (ZnCl2) for its subsequent use in the removal of amoxicillin. The biomass was characterized by elemental analysis and the activated carbon was characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), and Surface Area Analysis (BET) in order to determine the chemical composition, morphological and structural characteristics. For the assays of amoxicillin molecular adsorption, was used an aqueous solution of contaminant at 20 ppm, with pH 6 and 9, to which was added 5 g of adsorbent material impregnated with ZnCl2 at 1:3 and 1:4 ratios. These carbons reached surface areas of 287.5 m2/g and 205.4 m2/g, respectively, with average pore sizes from 3 to 4 nm. The percentage of amoxicillin removal was influenced by the pH of the solution to be treated, reaching the highest percentages of adsorption when the pH was acid; removal values achieved for activated carbon 1:3 were 75.4 % and 67.2 %, while for the activated carbon 1:4 were 65.2 % and 56.7 % for solutions at pH 6 and 9, correspondingly. It concludes that the activated carbon obtained at low temperature has potential to remove amoxicillin in aqueous solution and becomes a good alternative due to the availability of the residue. [ABSTRACT FROM AUTHOR]

Published
2017

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