Search

Your search keyword '"Almahal, Mohamed A."' showing total 6 results
Start Over Author "Almahal, Mohamed A."
6 results on '"Almahal, Mohamed A."'

2. Intrafamilial and interfamilial heterogeneity of PINK1-associated Parkinson's disease in Sudan

Author

Bakhit, Yousuf, primary, Ibrahim, Mohamed O., additional, Tesson, Christelle, additional, Elhassan, Ali A., additional, Ahmed, Mohamed Anwer, additional, Alebeed, Mohamed A., additional, Elrasheed, Salma M., additional, Omar, Mawia A., additional, Abubaker, Rayan, additional, Eltom, Khalid, additional, Shaheen, Mutaz T., additional, Ibrahim, Yousuf A., additional, Almak, Murad E., additional, Ali, Hiba A., additional, Abugrain, Ahmed A., additional, Almahal, Mohamed A., additional, MohamedSharif, Abubaker A., additional, Tahir, Mohamed Y., additional, Malik, Sawazen M., additional, Eldirdiri Abdelrahman, Hazim, additional, Khidir, Reem J., additional, Mohamed, Malaz T., additional, Abdalla, Abdelmohaymin, additional, Elsayed, Liena E.O., additional, Lesage, Suzanne, additional, Corvol, Jean-Christophe, additional, Seidi, Osheik, additional, and Wüllner, Ullrich, additional

Published
2023
Full Text
View/download PDF

3. Intrafamilial and interfamilial heterogeneity of PINK1-associated Parkinson's disease in Sudan

Author

Bakhit, Yousuf, Ibrahim, Mohamed O., Tesson, Christelle, Elhassan, Ali A., Ahmed, Mohamed Anwer, Alebeed, Mohamed A., Elrasheed, Salma M., Omar, Mawia A., Abubaker, Rayan, Eltom, Khalid, Shaheen, Mutaz T., Ibrahim, Yousuf A., Almak, Murad E., Ali, Hiba A., Abugrain, Ahmed A., Almahal, Mohamed A., MohamedSharif, Abubaker A., Tahir, Mohamed Y., Malik, Sawazen M., Abdelrahman, Hazim Eldirdiri, Khidir, Reem J., Mohamed, Malaz T., Abdalla, Abdelmohaymin, Elsayed, Liena E. O., Lesage, Suzanne, Corvol, Jean-Christophe, Seidi, Osheik, Wüllner, Ullrich, Bakhit, Yousuf, Ibrahim, Mohamed O., Tesson, Christelle, Elhassan, Ali A., Ahmed, Mohamed Anwer, Alebeed, Mohamed A., Elrasheed, Salma M., Omar, Mawia A., Abubaker, Rayan, Eltom, Khalid, Shaheen, Mutaz T., Ibrahim, Yousuf A., Almak, Murad E., Ali, Hiba A., Abugrain, Ahmed A., Almahal, Mohamed A., MohamedSharif, Abubaker A., Tahir, Mohamed Y., Malik, Sawazen M., Abdelrahman, Hazim Eldirdiri, Khidir, Reem J., Mohamed, Malaz T., Abdalla, Abdelmohaymin, Elsayed, Liena E. O., Lesage, Suzanne, Corvol, Jean-Christophe, Seidi, Osheik, and Wüllner, Ullrich

Abstract

PINK1 is the second most predominant gene associated with autosomal recessive Parkinson's disease. Homo-zygous mutations in this gene are associated with an early onset of symptoms. Bradykinesia, tremors, and rigidity are common features, while dystonia, motor fluctuation, and non-motor symptoms occur in a lower percentage of cases and usually respond well to levodopa. We investigated 14 individuals with parkinsonism and eleven symptom-free siblings from three consanguineous Sudanese families, two of them multigenerational, using a custom gene panel screening 34 genes, 27 risk variants, and 8 candidate genes associated with parkinsonism. We found a known pathogenic nonsense PINK1 variant (NM_032409.3:c.1366C>T; p.(Gln456*)), a novel pathogenic single base duplication (NM_032409.3:c.1597dup; p.(Gln533Profs*29)), and another novel pathogenic insertion (NM_032409.3:c.1448_1449ins[1429_1443; TTGAG]; p.(Arg483Serfs*7)). All variants were homozygous and co -segregated in all affected family members. We also identified intrafamilial and interfamilial phenotypic het-erogeneity associated with PINK1 mutations in these Sudanese cases, possibly reflecting the nature of the Sudanese population that has a large effective population size, which suggests a higher possibility of novel findings in monogenic and polygenic diseases in Sudan.

Published
2023
Full Text
View/download PDF

4. Methylation of alpha-synuclein in a Sudanese cohort

Author

Bakhit, Yousuf, primary, Schmitt, Ina, additional, Hamed, Ahlam, additional, Ibrahim, Etedal Ahmed A., additional, Mohamed, Inaam N., additional, El-Sadig, Sarah M., additional, Elseed, Maha A., additional, Alebeed, Mohamed A., additional, Shaheen, Mutaz T., additional, Ibrahim, Mohamed O., additional, Elhassan, Ali A., additional, Eltom, Khalid, additional, Ali, Hiba A., additional, Ibrahim, Yousuf A., additional, Almak, Murad E., additional, Abubaker, Rayan, additional, Ahmed, Mohamed Anwer, additional, Abugrain, Ahmed A., additional, Elrasheed, Salma M., additional, Omar, Mawia A., additional, Almahal, Mohamed A., additional, MohamedSharif, Abubaker A., additional, Tahir, Mohamed Y., additional, Malik, Sawazen M., additional, Eldirdiri, Hazim S., additional, Khidir, Reem J., additional, Mohamed, Malaz T., additional, Abdalla, Abdelmohaymin, additional, Omer, Farouk Yassen, additional, Elsayed, Liena E.O., additional, Babikir, Haydar El Hadi, additional, Bukhari, Elfateh Abd-Allah, additional, Seidi, Osheik, additional, and Wüllner, Ullrich, additional

Published
2022
Full Text
View/download PDF

5. Handheld echocardiographic screening for rheumatic heart disease in rural South Kordofan, Sudan by junior medicals: Supporting task shifting for control of a serious disease

Author

Elazrag, Amna M., primary, Altahir, Anfal M., additional, Abbas, Azza A., additional, Hasabo, Elfatih A., additional, Ahmed, Hayat A., additional, Ali, Hiba A.A, additional, Abdelrazig, Ibrahim M.I, additional, Ahmed, Mohamed Y., additional, Almahal, Mohamed A., additional, Siddig, Musab M., additional, Asmally, Rofida S., additional, Alrawa, Salma S., additional, Mohamedelrasheed, Salma M., additional, Ali, Sulafa K.M, additional, and Elnaiem, Walaa, additional

Published
2022
Full Text
View/download PDF

6. The psychological impact of COVID-19 pandemic among Sudanese population in Khartoum state, 2020

Author

Hamed, Yasir, Almahal, Mohamed, Adam, Tarig, Shaaban, Kamil, Mohamed, Ahmed, Mudawi, Amro, and Mageit, Murwan

Subjects
Anxiety, Depression, Financial stress, Social media, Social support
Abstract

The impact of coronavirus disease 2019 (COVID-19) extends beyond the physical domain. We aimed to explore the prevalence and risk factors of depression and anxiety in a sample of Sudanese citizens in Khartoum city. Depression and anxiety symptoms of 712 respondent were investigated using an online survey version of the 9-item Patient Health Questionnaire (PHQ-9), the 7-item Generalized Anxiety Disorder (GAD-7) and data on demographic characteristic, social media usage, financial stress, social support, quarantine status and COVID-19 infection were also collected. Depression and anxiety prevalence were found to be 78.2% and 65.3%, respectively. Comorbid depression/anxiety and anxiety/depression were found to be 78.6% and 94.2%, respectively. Old age, male gender, high social support and decreased financial stress were protective factors against depression and anxiety. Whereas increased time spent on social media for COVID-19 was a risk factor. A history of chronic illness, mental and quarantine were risk factors for depression only. Being a student and freelancer compared to unemployed and never exposed to COVID-19 on TV/radio were protective against anxiety only. It is suggested that further monitoring and interventions should be made for the mental health of the population.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results