134 results on '"Allweiss L"'
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2. Shutdown of HBV transcripts using siRNA followed by entry inhibition induces sustained silencing of the cccDNA in vivo
3. Both interferon and siRNA treatments promote reappearance of SMC5/6 complex but have different impact on cccDNA
4. Safety and Efficacy of 10 mg Myrcludex B/IFNa Combination Therapy in Patients with Chronic HBV/HDV Co-Infection
5. The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
6. Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
7. Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
8. Murine hepatocytes with humanized sodium taurocholat polypeptide (NTCP) limit HDV infection in vivo independent of adaptive immune responses
9. T cells grafted with HBV-specific T-cell receptors of high functional avidity achieve functional cure of HBV infection in humanized mice
10. Final results of a multicenter, open-label phase 2b clinical trial to assess safety and efficacy of Myrcludex B in combination with Tenofovir in patients with chronic HBV/HDV co-infection
11. Strong intrahepatic decline of hepatitis D virus RNA and antigen after 24 weeks of treatment with Myrcludex B in combinationwith Tenofovir in chronic HBV/HDV infected patients: Interim results from a multicenter, open-label phase 2b clinical trial
12. The protein complex structural maintenance of chromosomes reappears after interferon alpha treatment in hepatitis B virus infected humanized mice but its presence does not hinder viral rebound
13. Interferon α treatment leads to reappearance of the Smc5/6 complex in HBV-infected humanized mice and to its renewed degradation upon viral rebound
14. Hepatitis B virus-specific T cell receptors with high functional redirect T cells to eliminate HBV
15. Mutations in the basal core promoter of HBV lead to intracellular accumulation of viral nucleic acids in vivo
16. Hepatitis B virus activates expression of the RIG-like receptor pathway in murine intrahepatic cells in humanized mice
17. Efficacy of HDV mono-infection with genotype 1 and 3 in CRPISPR/Cas generated humanized NTCP mice compared to human liver chimeric mice
18. Serum HBV pgRNA can serve as clinical marker for cccDNA activity in patients with HBV mono and HBV/HDV co-infection
19. Hepatitis B virus infection alters the transcriptional regulation of FXR-dependent microRNAs
20. Comparison of HDV mono-infection with genotype 1 and 3 in CRPISPR/Cas generated humanized NTCP mice and human liver chimeric mice
21. HDV-GT3 shows similar induction of innate immunity compared to HDV-GT1 in humanized mice despite its high infection efficiency and intrahepatic activity
22. HBV infection alters the transcriptional regulation of FXR-dependent microRNAs
23. Innate Immune Sensing of Hepatitis B Virus and Response to Interferon Stimulation are Mostly Elicited in Non HBV Producing Human Hepatocytes in Vivo
24. Single Cell Analyses Demonstrate No Up-Regulation of Human Innate Genes in HDV Mono-Infected Human Hepatocytes
25. Immunotherapy using T Cells Redirected against HBV Results in Reduced Viral Loads and Enhanced Immune Responses in Humanized Mice
26. Prevention of Viral Spread, Viremia Reduction and HBsAg Clearance in Hepatitis B and D Coinfected Humanized Mice by a Human Neutralizing Monoclonal Antibody
27. Adaptive transfer of human T cells redirected against HBV results in reduced viral loads and induced immune responses in humanized mice
28. Lack of HBeAg does not induce stronger enhancement of innate immunity genes in humanized mice
29. SAT-370 - The protein complex structural maintenance of chromosomes reappears after interferon alpha treatment in hepatitis B virus infected humanized mice but its presence does not hinder viral rebound
30. SAT-364 - Murine hepatocytes with humanized sodium taurocholat polypeptide (NTCP) limit HDV infection in vivo independent of adaptive immune responses
31. PS-162 - Strong intrahepatic decline of hepatitis D virus RNA and antigen after 24 weeks of treatment with Myrcludex B in combinationwith Tenofovir in chronic HBV/HDV infected patients: Interim results from a multicenter, open-label phase 2b clinical trial
32. P0530 : Myrcludex-B inhibits establishment of HDV super-infection in HBV infected mice and reduces HDV viremia in stably HBV/HDV co-infected mice
33. P0554 : Hepatitis E virus infection induces an innate immune response in human chimeric mice
34. P0558 : HBV infection is not affected by the induction of FXR activity but may limit the activity of FXR agonists in humanized mice
35. O115 : High antiviral activity of the HBV core inhibitor NVR 3-778 in the humanized uPA/SCID mouse model
36. O012 : Hepatitis delta virus can survive liver regeneration and is amplified through human cell division both in vitro and in vivo
37. Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation
38. Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo
39. P179 BINDING OF HEPATITIS B VIRUS TO ITS CELLULAR RECEPTOR ALTERS THE EXPRESSION PROFILE OF GENES OF THE BILE ACID METABOLISM
40. O105 MICE WITH HUMAN LIVERS AS A NEW MODEL OF HEPATITIS E VIRUS INFECTION AND PRECLINICAL DRUG EVALUATION
41. O102 PROLIFERATION OF HBV-INFECTED HUMAN HEPATOCYTES IN HUMANIZED MICE PROMOTES THE OCCURRENCE OF VIRAL INTEGRATIONS WITHIN THE HOST GENOME
42. The expression profile of bile acid and cholesterol synthesis genes are affected by the binding of Hepatitis B Virus to its cellular receptor
43. Proliferation of hepatitis B virus infected human hepatocytes in humanized mice treated with the entry inhibitor Myrcludex-B induces strong cccDNA reduction and maintenance of cccDNA-free hepatocytes
44. Different antiviral effects induced by interferon or entecavir in HDV infected human-chimeric uPA/SCID mice determined by new intrahepatic qRT-PCR assay
45. FRI-219 - Prevention of Viral Spread, Viremia Reduction and HBsAg Clearance in Hepatitis B and D Coinfected Humanized Mice by a Human Neutralizing Monoclonal Antibody
46. THU-192 - Innate Immune Sensing of Hepatitis B Virus and Response to Interferon Stimulation are Mostly Elicited in Non HBV Producing Human Hepatocytes in Vivo
47. THU-190 - Single Cell Analyses Demonstrate No Up-Regulation of Human Innate Genes in HDV Mono-Infected Human Hepatocytes
48. PS032 - Immunotherapy using T Cells Redirected against HBV Results in Reduced Viral Loads and Enhanced Immune Responses in Humanized Mice
49. Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts
50. Zellteilung Hepatitis B Virus infizierter Hepatozyten führt zur schnellen Reduktion von cccDNA und viraler Replikation in humanisierten Mäusen
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