11 results on '"Allopurinol/*therapeutic use"'
Search Results
2. Severe tophaceous gouty arthritis can be treated but is still overlooked in healthcare
- Author
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Hamad, Ahmed Jamal Abbas and Rasmussen, Claus
- Subjects
Male ,Gout Suppressants/therapeutic use ,Humans ,Renal Insufficiency ,Allopurinol/therapeutic use ,Delivery of Health Care ,Aged ,Arthritis, Gouty/diagnosis - Abstract
This is a case report of a 68-year-old male with severe tophaceous gouty arthritis, diabetes, kidney impairment and ischaemic heart disease. The patient had repeated attacks of acute gout during a 20-year period and excessive tophaceous depositions. Walking was severely hampered by feet deformity and pain. No urate-lowering therapy was initiated despite contacts to several medical specialties. After the diagnosis was established, the patient was finally treated with allopurinol with an obvious beneficial effect on his symptoms and the size of the tophaceous depositions.
- Published
- 2022
3. Urolithiasis: evaluation, dietary factors, and medical management: an update of the 2014 SIU-ICUD international consultation on stone disease
- Author
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Petrisor Geavlete, Alberto Saita, Hemendra N. Shah, Andreas Neisius, Joe Philip, Dean G. Assimos, Yasuo Kohjimoto, Timothy D. Averch, Palle Jørn Sloth Osther, Helene Jung, and Sero Andonian
- Subjects
medicine.medical_specialty ,Urinalysis ,Urolithiasis/diagnosis ,Infrared Rays ,Diet therapy ,Allopurinol ,Sodium Chloride Symporter Inhibitors ,Urology ,030232 urology & nephrology ,Diuretics/therapeutic use ,Dietary factors ,Allopurinol/therapeutic use ,Kidney Calculi/diagnosis ,Gout Suppressants ,Fluid Therapy/methods ,Sodium Chloride Symporter Inhibitors/therapeutic use ,Kidney Calculi ,03 medical and health sciences ,0302 clinical medicine ,Urolithiasis ,X-Ray Diffraction ,Potassium Citrate ,medicine ,Humans ,Disease management (health) ,Diuretics ,Intensive care medicine ,Stone disease ,Ultrasonography ,Evidence-Based Medicine ,medicine.diagnostic_test ,business.industry ,Spectrum Analysis ,Disease Management ,Evidence-based medicine ,Clinical Practice ,030220 oncology & carcinogenesis ,Gout Suppressants/therapeutic use ,Practice Guidelines as Topic ,Physical therapy ,Fluid Therapy ,Diet Therapy/methods ,Best evidence ,Tomography, X-Ray Computed ,business ,Potassium Citrate/therapeutic use ,Diet Therapy - Abstract
PURPOSE: The aim of this review was to provide current best evidence for evaluation, dietary, and medical management of patients with urolithiasis.METHODS: Literature addressing evaluation, dietary, and medical management of urolithiasis was searched. Papers were analyzed and rated according to level of evidence (LOE), whereupon a synthesis of the evidence was made. Grade of recommendation (GOR) was judged from individual clinical experience and knowledge of the evidence according to the Oxford Centre for Evidence-based Medicine.RESULTS: It is obvious that different stone diseases influence the life of stone-forming individuals very differently, and that evaluation and medical management should be personalized according to risk of recurrence, severity of stone disease, presence of associated medical conditions, and patient's motivation. With regard to evaluation, dietary and medical management of patients with urolithiasis evidence from the literature suggest that selective metabolic evaluation may lead to rational dietary and medical management. Statements based on LOE and GOR are provided to guide clinical practice.CONCLUSION: The provided evidence for evaluation of patients with urolithiasis aims at defining patients at high risk for recurrent/complicated stone disease. Based on this approach, evidence-based dietary and medical management regimes are suggested.
- Published
- 2017
4. Bone mineral density and serum osteocalcin levels in patients with gout
- Author
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Atalay Dogru, Veli Cobankara, Ayse Balkarli, Cemile Canan Karatay, and Mehmet Şahin
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Male ,bone turnover ,genetic structures ,Gout ,Turkey ,Osteoporosis ,lumbar t score ,lumbar vertebra ,vitamin D ,blood level ,low density lipoprotein cholesterol ,Body Mass Index ,0302 clinical medicine ,Absorptiometry, Photon ,photon absorptiometry ,middle aged ,030212 general & internal medicine ,Femur ,antigout agent ,Correlation of Data ,Bone mineral ,dual energy X ray absorptiometry ,C reactive protein ,Lumbar Vertebrae ,biology ,Osteocalcin ,adult ,lumbar spine ,femoral neck ,creatinine ,Age Factors ,bone density ,General Medicine ,Middle Aged ,female ,030220 oncology & carcinogenesis ,femoral t score ,Female ,Serum osteocalcin ,Bone Remodeling ,triacylglycerol ,alkaline phosphatase ,musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,diagnostic imaging ,alanine aminotransferase ,Allopurinol ,Article ,Gout Suppressants ,03 medical and health sciences ,uric acid ,blood ,turkey (bird) ,Internal medicine ,medicine ,parathyroid hormone ,Humans ,In patient ,controlled study ,human ,procedures ,Absorptiometry, Photon/methods ,Allopurinol/*therapeutic use ,Femur/diagnostic imaging ,Gout/blood/diagnosis/drug therapy/epidemiology ,Gout Suppressants/therapeutic use ,Lumbar Vertebrae/diagnostic imaging ,Osteocalcin/*blood ,Osteoporosis/blood/diagnosis/epidemiology ,Turkey/epidemiology ,business.industry ,nutritional and metabolic diseases ,femoral ,scoring system ,medicine.disease ,major clinical study ,osteoporosis ,body mass ,enzyme linked immunosorbent assay ,Endocrinology ,osteopenia ,age ,monoclonal antibody ,biology.protein ,business - Abstract
Objective: The objective of the study is to evaluate the relation of gout with osteoporosis and serum osteocalcin (OC) levels. Material and methods: Seventy-five patients diagnosed with gout and 55 controls were included in the study. Comorbid conditions and drugs associated with osteoporosis were excluded. The T and Z scores from lumbar spine (L2-L4) and femur (neck, ward, trochanter, total) were determined by dual-energy X-ray absorptiometry (DXA). OC levels were measured by enzyme-linked immunosorbent assay. Results: Osteoporosis according to T scores of lumbar vertebrae L2-L4 was found to be significantly higher in patients with gout compared to the control group (p = 0.02). Lumbar spine T-score was -1.6 in gout group and -1.0 in controls. OC level was 7.9 ng/mL in the gout group and 18.9 ng/mL in the control group. There was a significant difference (p < 0.001). In addition, mean OC level was 12.4 +/- 6.9 ng/mL in the patients diagnosed with osteoporosis and 17.2 +/- 10.6 ng/mL in the patients that were classified as normal and a significant difference was established between the two groups (p = 0.03). A significant negative correlation was found between OC level and body mass index, age, and age at first attack. Similarly, femoral T-score established a negative correlation with parathyroid hormone, age, age at first attack, and allopurinol dose. Conclusion: Serum OC level can be a useful marker in the assessment of bone turnover and clinicians should keep osteoporosis in mind in gout patients. C1 [Dogru, Atalay] Dr Ersin Arslan Training & Res Hosp, Dept Internal Med, Div Rheumatol, TR-27010 Gaziantep, Turkey. [Balkarli, Ayse] Antalya Training & Res Hosp, Dept Internal Med, Div Rheumatol, Antalya, Turkey. [Karatay, Cemile Canan] Pamukkale Univ, Dept Internal Med, Denizli, Turkey. [Cobankara, Veli] Pamukkale Univ, Dept Internal Med, Div Rheumatol, Denizli, Turkey. [Sahin, Mehmet] Suleyman Demirel Univ, Dept Internal Med, Fac Med, Div Rheumatol, Isparta, Turkey.
- Published
- 2019
5. The management of gout in different clinical specialties in Turkey: a patient-based survey
- Author
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Öztürk MA, Mercan R, Gök K, Onat AM, Kısacık B, Kimyon G, Balkarlı A, Kaya A, Çobankara V, Balcı MA, Pamuk Ö, Yıldırım Çetin G, Sayarlıoğlu M, Şenel S, Tezcan ME, Küçük A, Üreten K, Şahin Ş, and Tufan A
- Subjects
musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,Adult ,Aged ,Allopurinol/*therapeutic use ,Colchicine/therapeutic use ,Female ,Gout/*therapy ,Gout Suppressants/therapeutic use ,Humans ,Internal Medicine ,Life Style ,Male ,Middle Aged ,Orthopedics/methods ,Patient Admission ,Physical Therapy Specialty ,Primary Health Care/methods ,Rheumatology/methods ,Surveys and Questionnaires ,Turkey ,Uric Acid/analysis - Abstract
Although gout is potentially curable, the management of this disease is often suboptimal. In this study, we investigated the treatment of gout in Turkey and also compared the management approaches to gout in different clinical specialties. Three hundred and nineteen consecutive patients (mean age 58.60 ± 12.8 years; 44 females, 275 males) were included in this multicenter study. A standardized form was generated to collect data about the patient's first admission to health care, the specialty of the doctor first diagnosed the gout, the treatment options for gout including attack management, patient referral, chronic treatment including medical treatment, and life style modifications. Forty patients were referred to another center without any treatment (12.8 %), and referral rate is most common among the primary care physicians (28.8 %). Colchicine was more commonly used for attack prophylaxis than allopurinol. Ninety-two patients had never been treated with allopurinol (28.8 %). Allopurinol prescription was less common among the primary care physicians and orthopedists, and highest among the rheumatologists. Recommendation of diet and life style modifications was less common among the primary care physicians and orthopedists, and highest among the rheumatologists. The rates of life style modification recommendation and long-term allopurinol prescription were 83.7 and 77.6 %, respectively, among the rheumatologists. Both acute and chronic management of gout is suboptimal in Turkey especially among the primary care physicians and orthopedists. Moreover, chronic treatment is even suboptimal among rheumatologists.
- Published
- 2016
6. Comparative Impact on Islet Isolation and Transplant Outcome of the Preservation Solutions Institut Georges Lopez-1, University of Wisconsin, and Celsior
- Author
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Frédéric Ris, Lionel Badet, Philippe Morel, Thierry Berney, Anne Wojtusciszyn, Coralie Brault, Sandrine Demuylder-Mischler, Géraldine Parnaud, Domenico Bosco, Nadja Niclauss, Pierre-Yves Benhamou, Department of Surgery, University of Geneva [Switzerland], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), EA 4100, University of Geneva [Switzerland]-University of Geneva [Switzerland], Pôle Information Médicale Evaluation Recherche (IMER), Hospices Civils de Lyon (HCL), Xénobiotiques, Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Centre médical universitaire de Genève (CMU), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Poitiers, Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), Centre Hospitalier Universitaire [Grenoble] (CHU), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Blood Glucose ,Male ,Adenosine ,Time Factors ,Disaccharides/therapeutic use ,[SDV]Life Sciences [q-bio] ,Islets of Langerhans Transplantation ,030230 surgery ,Disaccharides ,Allopurinol/therapeutic use ,Tissue Culture Techniques ,Electrolytes ,0302 clinical medicine ,Glutamates ,Histidine/therapeutic use ,Preservation solutions ,Insulin ,Adenosine/therapeutic use ,Mannitol ,Biological Markers/blood ,ComputingMilieux_MISCELLANEOUS ,geography.geographical_feature_category ,C-Peptide ,ddc:617 ,Diabetes Mellitus/blood/drug therapy/surgery ,Organ Preservation/methods ,Raffinose/therapeutic use ,Organ Preservation ,Electrolytes/therapeutic use ,Middle Aged ,Mannitol/therapeutic use ,Islet ,Glutathione ,Treatment Outcome ,Insulin/therapeutic use ,C-Peptide/blood ,Tissue and Organ Harvesting ,Tissue and Organ Harvesting/methods ,Female ,Glutamates/therapeutic use ,030211 gastroenterology & hepatology ,Adult ,medicine.medical_specialty ,Isolation (health care) ,Allopurinol ,Organ Preservation Solutions ,Hypoglycemic Agents/therapeutic use ,Islets of Langerhans ,Hemoglobin A, Glycosylated/metabolism ,03 medical and health sciences ,Raffinose ,Diabetes Mellitus ,medicine ,Hypoglycemic Agents ,Humans ,Histidine ,Retrospective Studies ,Glycated Hemoglobin ,Analysis of Variance ,Transplantation ,geography ,Chi-Square Distribution ,Blood Glucose/metabolism ,Organ Preservation Solutions/therapeutic use ,business.industry ,Islets of Langerhans/drug effects/metabolism ,Glutathione/therapeutic use ,Surgery ,business ,Biomarkers ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Institut Georges Lopez-1 (IGL-1) is a preservation solution similar to University of Wisconsin (UW) with reversed Na/K contents. In this study, we assessed the impact of IGL-1, UW, and Celsior (CS) solutions on islet isolation and transplant outcome.We retrospectively analyzed 376 islet isolations from pancreases flushed and transported with IGL-1 (n=95), UW (n=204), or CS (n=77). We determined isolation outcome and β-cell function in vitro. Transplanted patients were divided into three groups depending on preservation solution of pancreas, and islet graft function was assessed by decrease in daily insulin needs, C-peptide/glucose ratios, β-scores, and transplant estimated function at 1- and 6-month follow-up.IGL-1, UW, and CS groups were similar according to donor age, body mass index, and pancreas weight. There was no difference in islet yields between the three groups. Success rates, transplant rates, β-cell secretory function, and viability were similar for all three groups. We observed no difference in decreased insulin needs, C-peptide glucose ratios, β-scores, and transplant estimated function at 1- and 6-month follow-up between IGL-1, UW, and CS groups.Our study shows that IGL-1 is equivalent to UW or CS solutions for pancreas perfusion and cold storage before islet isolation and transplantation.
- Published
- 2012
7. Successful treatment of visceral leishmaniasis with fluconazole and allopurinol in a patient with renal failure
- Author
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Colakoglu M, Yaylali GF, Colakoglu NY, and Yilmaz M
- Subjects
macromolecular substances ,Allopurinol/*therapeutic use ,Antifungal Agents/*therapeutic use ,Antimetabolites/*therapeutic use ,Diabetic Nephropathies/complications ,Fluconazole/*therapeutic use ,Humans ,Leishmaniasis, Visceral/complications/*drug therapy ,Male ,Middle Aged ,Renal Insufficiency/*complications - Abstract
Standard treatments for visceral leishmaniasis (antimonials, amphotericin B and pentamidine) pose several problems. Failure of antimonials or severe toxicity is particularly troublesome in patients with renal insufficiency. We report a case of visceral leishmaniasis and renal insufficiency successfully treated with fluconazole and allopurinol for 4 months.
- Published
- 2006
8. Successful treatment of visceral leishmaniasis with fluconazole and allopurinol in a patient with renal failure
- Author
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Colakoglu M, Fidan Yaylali G, Yalcin Colakoglu N, and Yilmaz M
- Subjects
macromolecular substances ,Allopurinol/*therapeutic use ,Animals ,Antimetabolites/*therapeutic use ,Antiprotozoal Agents/*therapeutic use ,Diabetic Nephropathies/complications ,Drug Therapy, Combination ,Fluconazole/*therapeutic use ,Humans ,Leishmaniasis, Visceral/complications/*drug therapy ,Male ,Middle Aged ,Renal Insufficiency/*complications ,Treatment Outcome - Abstract
Standard treatments for visceral leishmaniasis (antimonials, amphotericin B and pentamidine) pose several problems. Failure of antimonials or severe toxicity is particularly troublesome in patients with renal insufficiency. We report a case of visceral leishmaniaisis and renal insufficiency successfully treated with fluconazole and allopurinol for 4 months.
- Published
- 2006
9. Ranitidine and oxygen derived free radical scavengers in haemorrhagic shock induced gastric lesions
- Author
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E C Tsimoyiannis, J C Tsimoyiannis, K Moutesidou, G Akalestos, Kotoulas Ob, and C J Sarros
- Subjects
medicine.medical_specialty ,Ranitidine/*therapeutic use ,Free Radicals ,Allopurinol ,Radical ,Ischemia ,chemistry.chemical_element ,Gastric Mucosa/*blood supply ,Emergency Nursing ,Shock, Hemorrhagic ,Ranitidine ,Allopurinol/therapeutic use ,Oxygen ,Group A ,Gastroenterology ,Superoxide dismutase ,Internal medicine ,medicine ,Gastric mucosa ,Animals ,Oxygen/*physiology ,biology ,business.industry ,Chemistry ,Shock, Hemorrhagic/*complications ,medicine.disease ,Ischemia/*etiology/prevention & control ,Surgery ,medicine.anatomical_structure ,Gastric Mucosa ,Catalase ,Shock (circulatory) ,Anesthesia ,Emergency Medicine ,biology.protein ,Female ,Rabbits ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Research Article ,medicine.drug - Abstract
The role of oxygen derived free radicals in gastric lesions induced by haemorrhagic shock and the protective effect of oxygen radical scavengers, allopurinol and ranitidine, were investigated. Forty five rabbits underwent haemorrhagic shock for 30 minutes and reinfusion of shed blood. They were killed 30 minutes later. The animals were divided in five groups: A (n = 10): Control, B (n = 10): intravenous ranitidine pretreatment, C (n = 10): oral allopurinol, 24 and 2 h before surgery; D (n = 10): intravenous pretreatment with superoxide Dismutase plus catalase, E (n = 5): 60 minute haemorrhagic shock without reinfusion and treatment. Erosions and/or petechiae in all animals in Group A were observed. Three animals in group B and C and 2 in group D (p less than 0.005, p less than 0.001) had gastric lesions. The lesions in the pretreatment groups were significantly smaller than in controls. Oxygen radicals plus HCl play an important role in shock induced gastric lesions. Oxygen radical antagonists show a significant protective role. Gut
- Published
- 1988
10. The role of oxygen-derived free radicals in peritoneal adhesion formation induced by ileal ischaemia/reperfusion
- Author
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Tsimoyiannis, E. C., Tsimoyiannis, J. C., Sarros, C. J., Akalestos, G., Moutesidou, K. J., Lekkas, E. T., and Kotoulas, O. B.
- Subjects
Reperfusion Injury/*complications ,Tissue Adhesions/prevention & control ,Free Radicals/*therapeutic use ,Rats, Inbred Strains ,Superoxide Dismutase/therapeutic use ,Peritoneal Diseases/*prevention & control ,Allopurinol/therapeutic use ,Dimethyl Sulfoxide/therapeutic use ,Rats ,Ileum/*blood supply ,Animals ,Drug Evaluation ,Catalase/therapeutic use ,Female - Abstract
The effectiveness of superoxide dismutase (SOD), catalase (CAT), dimethyl sulphoxide (DMSO) and allopurinol in prevention of peritoneal adhesion formation induced by complete vascular obstruction and reperfusion of an ileal segment was investigated in rats. The ischaemic period was 30 min. Group A (n = 20) were controls, group B (n = 15) received SOD 15,000 U/kg i.v. and group C (n = 17) the same dose of CAT immediately before induction of ischaemia. In group D (n = 20) DMSO 20 mg/kg was given i.v. 5 min before ischaemia, and group E (n = 20) received allopurinol orally 50 mg/kg daily for 2 days and also 2 hours before ischaemia. Ten days later adhesions had developed in 80% of group A, 40% of group B, 47% of group C and 45% of groups D and E (p less than 0.05). The severity of the adhesions was significantly less in the pretreated groups than in the controls. Oxygen-derived free radicals may be pathogenetically important for such adhesion formation. Xanthine oxidase is the principal source of oxygen radicals after a 30-min period of complete regional intestinal ischaemia. Acta Chir Scand
- Published
- 1989
11. A tumor lysis-like syndrome during therapy of visceral leishmaniasis
- Author
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Evangelos Liberopoulos, Alexandridis G, and Elisaf M
- Subjects
Adult ,Amphotericin B/*adverse effects ,Leishmaniasis, Visceral/*drug therapy ,Antimetabolites/therapeutic use ,Urine/chemistry ,Antiprotozoal Agents/*adverse effects ,Tumor Lysis Syndrome/drug therapy/*etiology/urine ,Fluid Therapy ,Humans ,Female ,Hydrogen-Ion Concentration ,Allopurinol/therapeutic use - Abstract
Reported herein for the first time in the literature is the case of a 41-yr-old woman who developed a tumor lysis-like syndrome, consisting of hyperkalemia, hyperphosphatemia, hyperuricemia, and acute renal insufficiency, soon after the initiation of chemotherapy for severe visceral leishmaniasis with liposomal amphotericin B. Allopurinol therapy, together with iv fluid administration and urine alkalization, resulted in full recovery of the metabolic abnormalities. Awareness of this condition can lead to prophylactic treatment as well as the early recognition and management of susceptible patients. Ann Clin Lab Sci
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