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3. Association of the Family Environment with Behavioural and Cognitive Outcomes in Children with Chromosome 22q11.2 Deletion Syndrome

Author

Allen, T. M., Hersh, J., and Schoch, K.

Abstract

Background: Children with 22q11.2 deletion syndrome (22q11DS) are at risk for social-behavioural and neurocognitive sequelae throughout development. The current study examined the impact of family environmental characteristics on social-behavioural and cognitive outcomes in this paediatric population. Method: Guardians of children with 22q11DS were recruited through two medical genetics clinics. Consenting guardians were asked to complete several questionnaires regarding their child's social, emotional and behavioural functioning, as well as family social environment and parenting styles. Children with 22q11DS were asked to undergo a cognitive assessment, including IQ and achievement testing, and measures of attention, executive function and memory. Results: Modest associations were found between aspects of the family social environment and parenting styles with social-behavioural and cognitive/academic outcomes. Regression models indicated that physical punishment, socioeconomic status, parental control and family organisation significantly predicted social-behavioural and cognitive outcomes in children with 22q11DS. Conclusion: Characteristics of the family social environment and parenting approaches appear to be associated with functional outcomes of children with 22q11DS. Understanding the impact of environmental variables on developmental outcomes can be useful in determining more effective targets for intervention. This will be important in order to improve the quality of life of individuals affected by 22q11DS.

Published
2014
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10. Randomized Multicenter Clinical Trial of Myofascial Physical Therapy in Women With Interstitial Cystitis/Painful Bladder Syndrome and Pelvic Floor Tenderness

Author

FitzGerald, M. P., Payne, C. K., Lukacz, E. S., Yang, C. C., Peters, K. M., Chai, T. C., Nickel, J. C., Hanno, P. M., Kreder, K. J., Burks, D. A., Mayer, R., Kotarinos, R., Fortman, C., Allen, T. M., Fraser, L., Mason-Cover, M., Furey, C., Odabachian, L., Sanfield, A., Chu, J., Huestis, K., Tata, G. E., Dugan, N., Sheth, H., Bewyer, K., Anaeme, A., Newton, K., Featherstone, W., Halle-Podell, R., Cen, L., Landis, J. R., Propert, K. J., Foster, H. E., Jr., Kusek, J. W., and Nyberg, L. M.

Published
2012

19. Association of the family environment with behavioural and cognitive outcomes in children with chromosome 22q11.2 deletion syndrome

Author

Allen, T. M., Hersh, J., Schoch, K., Curtiss, K., Hooper, S. R., and Shashi, V.

Subjects
Male, Parents, Adolescent, Parenting, Child Behavior, Article, Cognition, Predictive Value of Tests, Intellectual Disability, DiGeorge Syndrome, Humans, Regression Analysis, Family, Female, Child, Social Behavior
Abstract

Children with 22q11.2 deletion syndrome (22q11DS) are at risk for social-behavioural and neurocognitive sequelae throughout development. The current study examined the impact of family environmental characteristics on social-behavioural and cognitive outcomes in this paediatric population.Guardians of children with 22q11DS were recruited through two medical genetics clinics. Consenting guardians were asked to complete several questionnaires regarding their child's social, emotional and behavioural functioning, as well as family social environment and parenting styles. Children with 22q11DS were asked to undergo a cognitive assessment, including IQ and achievement testing, and measures of attention, executive function and memory.Modest associations were found between aspects of the family social environment and parenting styles with social-behavioural and cognitive/academic outcomes. Regression models indicated that physical punishment, socioeconomic status, parental control and family organisation significantly predicted social-behavioural and cognitive outcomes in children with 22q11DS.Characteristics of the family social environment and parenting approaches appear to be associated with functional outcomes of children with 22q11DS. Understanding the impact of environmental variables on developmental outcomes can be useful in determining more effective targets for intervention. This will be important in order to improve the quality of life of individuals affected by 22q11DS.

Published
2013

21. Royal Academy of Medicine in Ireland Section of Biological Sciences Proceedings of Summer Meeting, Trinity College Dublin Medical School, St. James’s Hospital, Dublin 8 on Thursday and Friday, 26th and 27th June, 1986

Author

Chan, H. C., Cocoman, L., Feely, J., O’Connor, J. J., Rowan, M. J., Anwyl, R., McGuinness, S., Casey, P., Pratt, I., Mahon, E., O’Connor, C. M., Gebruers, E. M., Hall, W. J., Lordan, J. L., Felle, P., Harding, B., Meharg, M. K., McHale, N. G., Flynn, R., Ghaly, R. G., Wilson, C. M., McClean, E., Moore, J., Dundee, J. W., Guckian, Mary, Gallagher, R. B., van Breda, A., Fitzgerald, M. X., Feighery, C., McCall, Therese, Bloomfield, J., O’Leary, D., O’Morain, C. A., Alwan, Adel, McCann, S., Whelan, A., Bowe, Frances, West, Brian, Cafferkey, Mary, Uprichard, A. C. G., Allen, J. D., Harron, D. W. G., Furness, G., Milligan, K. R., O’Toole, D. P., Howe, J. P., Neville, Sharon, Rogers, Paquita, Allen, T. M., O’Briain, D. S., Cahill, P., Martin, F., McDaid, M., Kernan, R. P., Folan, Jean C., Hooper, A. C. B., Brien, T. G., Lardner, A., O’Donohoe, M. K., Yasear, A. Y., Moore, R. E., Arbuthnott, Elinor R., Sheppard, B. L., Sheppard, U., Harmon, K., Harrison, R. F., Jaff, M. S., Sweeney, E. C., Cullen, D., Hassan, Jaythoon, Bresnihan, B., Bahendeka, S. K., Tomkin, G. H., Buchanan, K. D., Buga, G. A. B., Kelly, M., Anwyl, Roger, Lee, Wai-Ling, Rowan, Michael, Maki, Amel, Thornbury, K. D., McCarron, J. G., Allen, J. M., McCullough, J. S., Moynihan, J. B., Breathnach, C. S., Power, Claire, Al-Arabi, A., Andrews, J. F., Dockeray, C. J., Daly, L., Bonnar, J., Jande, M. B., Sharma, S. C., Reynolds, Maura, McCann, Shaun R., Barron, D. W., McKay, A. C., Foster, J. C., Maxwell, W. J., Walsh, J. P., Hogan, F. P., Bloomfield, F. J., Kennedy, N. P., Keeling, P. W. N., Lynas, A. G. A., Clarke, R. S. J., Fee, J. P. H., Reid, J. E., Finegan, J., Evans, J., Abraham, D., and MacMathuna, P.

Published
1987
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23. Populational analysis reveals a link between complex viral escape from CD8+ T-Cell responses and protection in HCV infection

Author

Kuntzen, T., Neumann-Haefelin, Christoph, Lennon, N., Talal, A. H., Carlson, J., Brumme, C., Timm, Jörg, Schmidt, J., Wunsch, K., Berical, A., Berlin, A. M., Adams, S., Young, S. K., Reyor, L. L., Kleyman, M., McMahon, C. M., Birch, C., Schulze zur Wiesch, J., Ledlie, T., Michael, K., Kodira, C., Roberts, A. D., Schneidewind, A., Lauer, G. M., Kim, A. Y., Rosen, H. R., Bihl, F., Cerny, A., Spengler, U., Brander, C., Galagan, J. E., Nusbaum, C., Walker, B. D., Lake-Bakaar, G. V., Daar, E. S., Jacobson, I. M., Gomperts, E. D., Edlin, B. R., Donfield, S. M., Chung, R. T., Marion, T., Birren, B. W., Marincola, F., Thimme, R., Carrington, M., Heckerman, D., Henn, M. R., and Allen, T. M.

Subjects
Medizin
Published
2011

26. Tat-Specific CTL Exert Strong Selective Pressure During Acute SIV Infection

Author

O'Connor, D., Allen, T. M., Jing, P., Dzuris, J. L., Dunphy, E., Mothé, B. R., Liebl, M. E., Vogel, T. U., Mortara, Lorenzo, Dodds, E., Emerson, C., Kunstman, K. J., Wang, X., Hughes, A. L., Desrosiers, R. C., Altman, J. D., Wolinsky, S. M., Sette, A., and Watkins, D. I.

Published
2000

28. Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection

Author

Brumme, Z. L., Brumme, C. J., Carlson, J., Streeck, H., John, M., Eichbaum, Q., Block, B. L., Baker, B., Kadie, C., Markowitz, M., Jessen, H., Kelleher, A. D., Rosenberg, E., Kaldor, J., Yuki, Y., Carrington, M., Allen, T. M., Mallal, S., Altfeld, M., Heckerman, D., Walker, B. D., Brumme, Z. L., Brumme, C. J., Carlson, J., Streeck, H., John, M., Eichbaum, Q., Block, B. L., Baker, B., Kadie, C., Markowitz, M., Jessen, H., Kelleher, A. D., Rosenberg, E., Kaldor, J., Yuki, Y., Carrington, M., Allen, T. M., Mallal, S., Altfeld, M., Heckerman, D., and Walker, B. D.

Abstract

During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely characterized. In a cohort of 98 individuals newly infected with HIV-1 subtype B, we longitudinally characterized the rates and extent of HLA-mediated escape and reversion in Gag, Pol, and Nef using a rational definition of HLA-attributable mutation based on the analysis of a large independent subtype B data set. We demonstrate rapid and dramatic HIV evolution in response to immune pressures that in general reflect established cytotoxic T-lymphocyte (CTL) response hierarchies in early infection. On a population level, HLA-driven evolution was observed in ∼80% of published CTL epitopes. Five of the 10 most rapidly evolving epitopes were restricted by protective HLA alleles (HLA-B*13/B*51/B*57/B*5801; P = 0.01), supporting the importance of a strong early CTL response in HIV control. Consistent with known fitness costs of escape, B*57-associated mutations in Gag were among the most rapidly reverting positions upon transmission to non-B*57-expressing individuals, whereas many other HLA-associated polymorphisms displayed slow or negligible reversion. Overall, an estimated minimum of 30% of observed substitutions in Gag/Pol and 60% in Nef were attributable to HLA-associated escape and reversion events. Results underscore the dominant role of immune pressures in driving early within-host HIV evolution. Dramatic differences in escape and reversion rates across codons, genes, and HLA restrictions are observed, highlighting the complexity of viral adaptation to the host immune response.

Published
2008

31. HLA Footprints on Human Immunodeficiency Virus Type 1 Are Associated with Interclade Polymorphisms and Intraclade Phylogenetic Clustering

Author

Matthews, P. C., primary, Leslie, A. J., additional, Katzourakis, A., additional, Crawford, H., additional, Payne, R., additional, Prendergast, A., additional, Power, K., additional, Kelleher, A. D., additional, Klenerman, P., additional, Carlson, J., additional, Heckerman, D., additional, Ndung'u, T., additional, Walker, B. D., additional, Allen, T. M., additional, Pybus, O. G., additional, and Goulder, P. J. R., additional

Published
2011
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32. Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

Author

Kasprowicz, V., primary, Kang, Y.-H., additional, Lucas, M., additional, Schulze zur Wiesch, J., additional, Kuntzen, T., additional, Fleming, V., additional, Nolan, B. E., additional, Longworth, S., additional, Berical, A., additional, Bengsch, B., additional, Thimme, R., additional, Lewis-Ximenez, L., additional, Allen, T. M., additional, Kim, A. Y., additional, Klenerman, P., additional, and Lauer, G. M., additional

Published
2011
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33. High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

Author

Kasprowicz, V., primary, zur Wiesch, J. S., additional, Kuntzen, T., additional, Nolan, B. E., additional, Longworth, S., additional, Berical, A., additional, Blum, J., additional, McMahon, C., additional, Reyor, L. L., additional, Elias, N., additional, Kwok, W. W., additional, McGovern, B. G., additional, Freeman, G., additional, Chung, R. T., additional, Klenerman, P., additional, Lewis-Ximenez, L., additional, Walker, B. D., additional, Allen, T. M., additional, Kim, A. Y., additional, and Lauer, G. M., additional

Published
2011
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