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Objectives To assess the ability of two risk prediction models in interstitial lung disease (ILD) to predict death or lung transplantation in a cohort of patients with interstitial pneumonia with autoimmune features (IPAF). Methods We performed a retrospective cohort study of adults with IPAF at an academic medical centre. The primary outcome was a composite of lung transplantation or death. We applied the patient data to the previously described Gender–Age–Physiology (GAP) and ILD-GAP models to determine the ability of these models to predict the composite outcome. Model discrimination was assessed using the c-index, and model calibration was determined by comparing the incidence ratios of observed vs expected deaths. Results Ninety-four patients with IPAF were included. Mean (s. d.) age was 58 (13.5) years and the majority were female (62%). The majority met serologic and morphologic criteria for IPAF (94% and 91%, respectively). The GAP model had a c-index of 0.664 (95% CI 0.547–0.781), while the ILD-GAP model had a c-index of 0.569 (95% CI 0.440–0.697). In those with GAP stage 1 or GAP stage 2 disease, calibration of the GAP model was satisfactory at 2 and 3 years for the cumulative end point of lung transplantation or death. Conclusion In patients with IPAF, the GAP model performed well as a predictor of lung transplantation or death at 2 years and 3 years from ILD diagnosis in patients with GAP stage 1 and GAP stage 2 disease. [ABSTRACT FROM AUTHOR]

Can prosecutions by US authorities help spread enforcement of foreign bribery laws to other countries? In this article, we explore this question by re-examining earlier scholarship that found that US prosecutions of foreign corporations under the Foreign Corrupt Practices Act (FCPA) increase the likelihood that the corporation's home state will enforce its own foreign bribery laws. Using a conditional-frailty Cox model that allows us to model foreign bribery enforcement actions as repeat-events, we do not find evidence that FCPA prosecutions lead to sustained increases of foreign bribery enforcement by target countries. We also find that prior results are not robust to the inclusion of an important confounding variable: a country's level of exposure to corruption in their trading partners. Still, while our findings indicate a more limited role of US law enforcement in this area, we nonetheless see many promising avenues for future research on transnational law enforcement and its consequences. [ABSTRACT FROM AUTHOR]

Reversible phosphorylation is a fundamental mechanism for controlling protein function. Despite the critical roles phosphorylated proteins play in physiology and disease, our ability to study individual phospho-proteoforms has been hindered by a lack of versatile methods to efficiently generate homogeneous proteins with site-specific phosphoamino acids or with functional mimics that are resistant to phosphatases. Genetic code expansion (GCE) is emerging as a transformative approach to tackle this challenge, allowing direct incorporation of phosphoamino acids into proteins during translation in response to amber stop codons. This genetic programming of phospho-protein synthesis eliminates the reliance on kinase-based or chemical semisynthesis approaches, making it broadly applicable to diverse phospho-proteoforms. In this comprehensive review, we provide a brief introduction to GCE and trace the development of existing GCE technologies for installing phosphoserine, phosphothreonine, phosphotyrosine, and their mimics, discussing both their advantages as well as their limitations. While some of the technologies are still early in their development, others are already robust enough to greatly expand the range of biologically relevant questions that can be addressed. We highlight new discoveries enabled by these GCE approaches, provide practical considerations for the application of technologies by non-GCE experts, and also identify avenues ripe for further development. [ABSTRACT FROM AUTHOR]

Recently, there has been a renewed interest in avoidance behavior, and its applicability to clinical conditions such as anxiety, posttraumatic stress disorder (PTSD) and addiction. In a computer-based avoidance task for humans, participants control an on-screen spaceship, shoot at enemy targets (appetitive cue) to gain points, and learn to respond to an on-screen warning signal (WS) by entering safe "hiding" areas to escape/avoid an aversive event (point loss and on-screen explosion) paired with an on-screen aversive cue (bomb). Prior research on active avoidance in rodents suggests that avoidance learning is facilitated if the response also terminates the WS. Here, we adapted the computer-based task to investigate this idea in healthy humans. Two hundred and twenty-two young adults completed one of three conditions of the task: a non-contingent condition, where hiding caused omission/avoidance of the aversive event but did not terminate the WS; a fully-contingent condition, where hiding also caused omission/termination of all on-screen appetitive and aversive cues as well as terminating the WS; and a partially-contingent condition where hiding caused omission of the appetitive and aversive cues, but did not affect the WS. Both contingency manipulations decreased escape/avoidance behavior, as compared to the non-contingent condition where the WS and other cues are not affected by the avoidance behavior. This study has implications for the basic understanding of the mechanisms that affect avoidance behavior in humans. [ABSTRACT FROM AUTHOR]

In the face of anthropogenic climate change, the ability of communities to reduce the heat-health burden remains a significant public health issue. This research is the first to identify cooling centers across the southeastern United States, providing a resource for stakeholders. The study evaluates the spatial relationship of these venues for heat-vulnerable populations. Using a survey and publicly available data, researchers identified 1,433 cooling centers, though significant variability exists across states and local jurisdictions. Of the nine states examined, Tennessee was the only location with a health system–supported cooling center network. Only 36 percent of the Southeast's population lives within a fifteen-minute drive of a cooling center. In most states, less than 10 percent of vulnerable populations (elderly, non-white, below poverty) are within this driveshed. Most cooling centers were found in urban environments, although heat vulnerability is not exclusively a city issue. Further research is needed to strengthen cross-agency collaboration and evaluate the effectiveness of cooling centers in areas of both high and low population density. Some states have integrated heat as part of hazard mitigation plans, but additional research is needed to explore how these plans go beyond hazard identification and strengthen vulnerable communities' ability to mitigate heat risk. [ABSTRACT FROM AUTHOR]

Political philosophers often appeal to the idea of natural prescriptions for action conducive to peace. Mohandas Gandhi is no exception, appealing to Nature’s Great Law, its associated Duty, and Right to Live, underwriting his conception of Ramarajya. This establishes some complex relations to the ideas of the State of Nature, Natural Law and Right in the early modern Western philosophers Thomas Hobbes and John Locke. This article explores these relations and the plausibility of Hobbesian and Lockean objections that Gandhi’s natural prescriptions for peace are unnecessary, unrealistic, and dangerous. [ABSTRACT FROM AUTHOR]

Background: Hand infections are heterogeneous, and some may undergo successful outpatient management. There are no strict guidelines for determining which patients will likely require inpatient admission for successful treatment, and many patients succeed with outpatient therapy. We sought to determine risk factors for failed outpatient management of cellulitic hand infections. Methods: We performed a retrospective review of patients who presented to the Emergency Department (ED) for hand cellulitic infections over five years, from 2014 to 2019. Vital signs, lab markers, Charlson Comorbidity Index (CCI), Elixhauser Comorbidity Measure (ECM), and antibiotic use were investigated. Discharge from the ED without subsequent admission was considered an outpatient success, while admission within 30 days of the prior visit was considered a failure. Continuous variables were compared with Welch's t test, and categorical data with Fisher's exact tests. Multivariable logistic regression was performed on comorbidities. Multiple testing adjustment was performed on p-values to generate q-values. Results: Outpatient management was attempted for 1,193 patients. 31 (2.6%) infections failed treatment, and 1,162 (97.4%) infections succeeded. Attempted outpatient treatment was 97.4% successful. Multivariable analysis demonstrated higher odds of failure with renal failure according to both CCI (OR 10.2, p < 0.001, q = 0.002) and ECM (OR 12.63, p = 0.003, q = 0.01) and with diabetes with complications according to the CCI (OR 18.29, p = 0.021, q = 0.032). Conclusions: Outpatient treatment failure was higher in patients with renal failure and complicated diabetes. These patients require a high index of suspicion for outpatient failure. These comorbidities should influence consideration for inpatient therapy though most patients can undergo successful treatment as outpatients. Level of evidence: Level III. [ABSTRACT FROM AUTHOR]

Background: Approximately half of those who attempt suicide report experiencing suicidal ideation and suicidal planning in advance; others deny these experiences. Some researchers have hypothesized that rapid intensification is due to past suicidal ideation and/or behaviors that are "mentally shelved" but remain available for rapid access later. Method: To evaluate this hypothesis, we examined (a) temporal sequencing of suicidal ideation, suicidal planning, and suicidal behavior, and (b) speed of emergence of suicidal behavior in a prospective cohort study of 2744 primary care patients. Results: Of 52 patients reporting suicidal behavior during follow‐up, 20 (38.5%) reported suicidal ideation and planning prior to their suicidal behavior, 23 (44.2%) reported suicidal ideation but not planning, and nine (17.3%) denied both suicidal ideation and planning. Over half (n = 30, 57.7%) reported the onset of suicidal ideation and/or planning on the same day as or after their suicidal behavior (i.e., rapid intensification). Rapid intensification was not associated with increased likelihood of reporting recent or past suicidal ideation, planning, or behaviors, suggesting rapid intensification does not depend on prior experience with suicidal ideation and/or behaviors. Conclusion: Detecting primary care patients at risk for this form of suicidal behavior may be limited even with universal suicide risk screening. [ABSTRACT FROM AUTHOR]

The article offers information on the motion of active colloidal clusters and the interactions between them. It discusses about observing activity-dependent behavior of spinning, circular, and orbital motions; collisions between dumbbells lead to the hierarchical self-assembly of tetramers and hexamers, both of which form rotational excited states; and focusing on self-assembled dumbbells and trimers powered by an external dc electric field.

Summary: Sea-level rise threatens both human communities and vulnerable species within coastal areas. Joint spatial planning can allow conservation and social resiliency goals to work in synergy. We present a case study integrating distribution information of a threatened saltmarsh bird, the eastern black rail (Laterallus jamaicensis jamaicensis), with social information to facilitate such joint planning. We constructed a distribution model for the species within an urbanizing coastal region (New Jersey, USA) and integrated this with publicly available parcel and protected area data to summarize ownership patterns. We estimated that c. 0.3–2.8% (c. 260–2200 ha) of available saltmarsh is occupied by eastern black rail, most of which is publicly owned (79%). Privately owned saltmarsh was spread across nearly 5000 individual parcels, 10% of which contained areas with the highest likelihood of rail presence according to our model (top quartile of predicted occupancy probabilities). Compared with all privately owned saltmarsh, parcels with probable rail habitat were larger (median: 5 versus 2 ha), contained more marsh (87% versus 59%) and were less economically valuable (US$11 200 versus US$36 100). Our approach of integrating species distributions with landownership data helps clarify trade-offs and synergies in species conservation and coastal resiliency planning. [ABSTRACT FROM AUTHOR]

Energy intake and partitioning are determined by many interacting factors and their prediction is the Achilles' heel of ration formulation. Inadequate energy intake can limit milk yield and reproductive performance, whereas excessive energy intake will increase body condition, increasing the risk of health and reproductive issues in the subsequent lactation. Ration composition interacts with the physiological state of cows, making it difficult to predict DMI and the partitioning of energy accurately. However, understanding the factors controlling these allows us to devise grouping strategies and manipulate rations to optimize energy intake through lactation. Eating is controlled by the integration of signals in brain feeding centers. Ration composition affects DMI of cows via signals from ruminal distention and the hepatic oxidation of fuels. Dairy cow rations must contain a minimal concentration of relatively low-energy roughages for proper rumen function, but signals from ruminal distension can limit DMI when the drive to eat is high. Signals from the hepatic oxidation of fuels likely dominate the control of DMI in the peripartum period when cows are in a lipolytic state and later in lactation when signals from distension diminish. Therefore, the effects of the ration on DMI vary with the physiological state of the animal. Furthermore, they interact with environmental stressors such as social (e.g., overcrowding) and thermal stress. The objective of this article is to discuss the effects of ration composition on energy intake and partitioning in lactating cows and how they can be manipulated to optimize productive performance. [ABSTRACT FROM AUTHOR]

Environmental DNA (eDNA) approaches to monitoring biodiversity in terrestrial environments have largely focused on sampling water bodies, potentially limiting the geographic and taxonomic scope of eDNA investigations. We assessed the performance of two strictly terrestrial eDNA sampling approaches to detect arboreal mammals, a guild with many threatened and poorly studied taxa worldwide, within two central New Jersey (USA) woodlands. We evaluated species detected with metabarcoding using two eDNA collection methods (tree bark vs. soil sampling), and compared the performance of two detection methods (qPCR vs. metabarcoding) within a single species. Our survey, which included 94 sampling events at 21 trees, detected 16 species of mammals, representing over 60% of the diversity expected in the area. More DNA was found for the 8 arboreal versus 8 non-arboreal species detected (mean: 2466 vs. 289 reads/sample). Soil samples revealed a generally similar composition, but a lower diversity, of mammal species. Detection rates for big brown bat were 3.4 × higher for qPCR over metabarcoding, illustrating the enhanced sensitivity of single-species approaches. Our results suggest that sampling eDNA from on and around trees could serve as a useful new monitoring tool for cryptic arboreal mammal communities globally. [ABSTRACT FROM AUTHOR]

The foundation of post–WWII US foreign policy is the deployment and maintenance of a vast network of overseas military deployments. While the external security implications of these deployments are better known, scholars have spent little time connecting deployments to the internal stability threat of a coup d'état. The deployment of service members overseas creates multiple pathways to decreasing the likelihood of coup attempts by both supporting the government and its security apparatus and decreasing the benefits of a successful attempt by coup d'état conspirators. Our analysis of coups from 1951 to 2019 demonstrates that the presence of US troops decreases the likelihood of a coup. [ABSTRACT FROM AUTHOR]

Reptiles are increasingly of conservation concern due to their susceptibility to habitat loss, emerging disease, and harvest in the wildlife trade. However, reptile populations are often difficult to monitor given the frequency of crypsis in their life history. This difficulty has left uncertain the conservation status of many species and the efficacy of conservation actions unknown. Environmental DNA (eDNA) surveys consistently elevate the detection rate of species they are designed to monitor, and while their use is promising for terrestrial reptile conservation, successes in developing such surveys have been sparse. We tested the degree to which inclusion of surface and soil eDNA sampling into conventional artificial‐cover methods elevates the detection probability of a small, cryptic terrestrial lizard, Scincella lateralis. The eDNA sampling of cover object surfaces with paint rollers elevated per sample detection probabilities for this species 4–16 times compared with visual surveys alone. We readily detected S. lateralis eDNA under cover objects up to 2 weeks after the last visual detection, and at some cover objects where no S. lateralis were visually observed in prior months. With sufficient sampling intensity, eDNA testing of soil under cover objects produced comparable per sample detection probabilities as roller surface methods. Our results suggest that combining eDNA and cover object methods can considerably increase the detection power of reptile monitoring programs, allowing more accurate estimates of population size, detection of temporal and spatial changes in habitat use, and tracking success of restoration efforts. Further research into the deposition and decay rates of reptile eDNA under cover objects, as well as tailored protocols for different species and habitats, is needed to bring the technique into widespread use. [ABSTRACT FROM AUTHOR]

Competition policy has been a central forum for contesting the uneasy relationship between capitalism and democracy since the late nineteenth century. From the earliest policy debates, concerns that robust competition policies aimed at limiting economic concentration would disadvantage domestic producers featured prominently. This dynamic creates an international cooperation problem over competition policy that has intensified with the dramatic increases in globalization over the last several decades. Understanding the causes and consequences of this cooperation problem is central to understanding global governance of the world economy, including the ability of democratic states to manage global capitalism in a manner that sustains democracy. This essay frames the challenge that global competition policy has posed over the last hundred years and argues that democratic major powers have played a critical role in shaping the limited cooperation that has been achieved. A research agenda that develops integrated theories of domestic and international competition policymaking as well as a multi-method empirical agenda for describing and explaining policy outcomes and their consequences for economic inequality, growth, and democracy is an essential task for international relations scholars. [ABSTRACT FROM AUTHOR]

Background: End‐of‐life (EOL) chemotherapy administration rates for solid tumours are 12–20% and are associated with a reduced quality of life, increased hospitalisation and incidence of death within an acute care facility. Aim: We sought to determine the rate of EOL chemotherapy in government and private hospitals and determine the impact on hospitalisations and location of death in lung and pancreatic cancer patients. Methods: Data were obtained from the Queensland Oncology Repository between 2005 and 2014. Lung (n = 16 501) and pancreatic cancer (n = 4144) deaths were analysed. EOL chemotherapy was determined to be within 30 days of death. Demographics, location of treatment and death are reported. Results: Chemotherapy was administered to 6518 (40%) lung cancer and 1694 (41%) pancreatic cancer patients. A total of 1474 (9%) and 477 (12%) patients, respectively, received EOL chemotherapy. EOL chemotherapy was more common in males and those with distant metastatic disease, while less likely in the elderly and those with a lower socioeconomic status. EOL chemotherapy was more prevalent in large hospitals and was more common in private compared with government hospitals for pancreatic cancer (30 vs 26%; P < 0.001), while it was similar for lung cancer (24 vs 22%; P = 0.115). Death after EOL chemotherapy compared with all cancer deaths was more common in an acute care facility (lung cancer: 60 vs 37%; P < 0.001; pancreatic cancer: 53 vs 36%; P < 0.001). Conclusions: EOL chemotherapy rates were similar to Australian yet marginally lower than international rates, with variation dependent on the size and type of facility and increased the rate of deaths within an acute care facility. [ABSTRACT FROM AUTHOR]

Investigation of virus-induced microalgal host lysis and the associated infection dynamics typically requires sampling of infected cultures at multiple timepoints, visually monitoring the state of infected cells, or determining virus titration within the culture media. Such approaches require intensive effort and are prone to low sensitivity and high error rates. Furthermore, natural physiological variations can become magnified by poor environmental control, which is often compounded by variability in virus stock efficacy and relatively long infection cycles. We introduce a new method that closely monitors host health and integrity to learn about the infection strategy of Chloroviruses. Our approach combines aspects of spectrometry, plaque assays, and infection dose assessment to monitor algal cells under conditions more representative of the natural environment. Our automated method exploits the continuous monitoring of infected microalgae cultures in highly controlled lab-scale photobioreactors that provide the opportunity for environmental control, technical replication, and intensive culture monitoring without external intervention or culture disruption. This approach has enabled the development of a protocol to investigate molecular signalling impacting the virus life cycle and particle release, accurate determination of virus lysis time under multiple environmental conditions, and assessment of the functional diversity of multiple virus isolates. [ABSTRACT FROM AUTHOR]

Migration is a prevalent strategy among birds used to track seasonal resources throughout the year. Individual and population‐level migratory movements provide insight to life‐history variation, carry‐over effects, and impacts of climate change. Our understanding of how geographic variation in a species' breeding or wintering grounds can impact migration distances is limited. However, changes in migration distances can have important fitness consequences for individuals and conservation implications for populations, particularly if migratory connectivity is altered during the annual cycle. In this study, we use three decades of data from the United States Geological Survey Bird Banding Laboratory for six migratory species of Arctic and subarctic breeding geese. We employ a Bayesian hierarchical framework to test if the distance between breeding and wintering locations has changed over time, while accounting for the latitude of the breeding grounds. A model that included only a temporal trend estimated the average rate of change in migration distance, across all six species, at −3.0 km/year over the period 1990–2019. Five of the six species showed a significant decrease in migration distances. Including an interaction effect with breeding latitude revealed that the reduction in migration distance was strongest in the southernmost populations for four of the six species. For those species, migration distance in northern populations were all either relatively unchanged or increasing. This indicates that southern breeding populations of geese had a stronger association with the observed spatiotemporal changes in wintering ranges, potentially influenced by a combination of climatic and biotic factors (e.g. resource availability or competitive interactions) that uniquely impact these populations. Abundant, long‐term banding data shows promise for use in illuminating changes in migratory patterns under climate change, leading to improved management and conservation outcomes, from regional to continental scales. [ABSTRACT FROM AUTHOR]

Native upland grasslands, while always uncommon, have mostly vanished in the past two centuries in eastern North America due to systematic (and synergistic) changes in land use and disturbance regimes ([2]). Managed grassland preserves, such as the Shawangunk Grasslands National Wildlife Refuge in New York, are rare in the region partly due to the difficulty and high cost of managing grassland habitat where both woody vegetation and invasive species thrive ([10], [2]). Landfill Restoration for (and Despite) the Birds The specific approach of the 2019-2020 Croton Point restoration plan was very aggressive, with possible negative consequences for native wildlife, including the grassland birds it was meant to benefit. [Extracted from the article]

Purpose: Over 95% of patients who screen positive on the Patient Health Questionnaire-9 (PHQ-9) suicide risk item do not attempt or die by suicide, which could lead to unnecessary treatment and/or misallocation of limited resources. The present study seeks to determine if suicide risk screening can be meaningfully improved to identify the highest-risk patients.Methods: Patients eligible to receive medical treatment from the US Department of Defense medical system were recruited from 6 military primary care clinics located at 5 military installations around the United States. Patients completed self-report measures including the PHQ-9 and 16 items from the Suicide Cognitions Scale (SCS) during routine primary care clinic visits. Postbaseline suicidal behaviors (suicide attempts, interrupted attempts, and aborted attempts) were assessed by evaluators who were blind to screening results using the Self-Injurious Thoughts and Behaviors Interview.Results: Among 2,744 patients, 13 (0.5%) engaged in suicidal behavior in the 30 days after screening and 28 (1.0%) displayed suicidal behavior in the 90 days after screening. Multiple SCS items differentiated patients with suicidal behavior less than 30 days after screening positive for suicide risk. Augmenting the PHQ-9 suicide risk item with SCS items improved the identification of patients who were most likely to have suicidal behavior within a month of screening positive without sacrificing sensitivity.Conclusion: Among primary care patients who screen positive for suicide risk on the PHQ-9, SCS items improved screening efficiency by identifying those patients who are most likely to engage in suicidal behavior within the next 30 days. [ABSTRACT FROM AUTHOR]

Our objective was to evaluate effects of corn grain endosperm type and fineness of grind on feed intake, feeding behavior, and productive performance of lactating cows. Eight ruminally and duodenally cannulated Holstein cows in mid lactation (130 ± 42 d in milk; mean ± standard deviation) were used in a duplicated 4 × 4 Latin square design with 21-d periods. A 2 × 2 factorial arrangement of treatments was used with main effects of corn grain endosperm type (floury or vitreous) and fineness of grind (fine or medium). Rations included alfalfa silage, corn treatments, protein supplement, minerals, and vitamins and were formulated to contain 29% starch, 27% neutral detergent fiber, 18.2% forage neutral detergent fiber, and 18% crude protein. Corn grain treatments supplied 86.2% of dietary starch. Endosperm was 25% vitreous for the floury treatment and 66% vitreous for the vitreous treatment. The floury treatment increased rate of starch degradation by 94% (19.2 vs. 9.9%/h) and decreased rate of starch passage by 38% (16.1 vs. 25.8%/h), increasing apparent ruminal starch digestibility by 117% (53.7 vs. 24.7%). The floury treatment increased total-tract starch digestibility by 8% (92.2 vs. 85.1%) despite 37% lower postruminal starch digestion for the floury treatment compared with vitreous corn (38.4 vs. 60.7% of starch intake). Fine grind size increased apparent ruminal starch digestibility by 52% (47.2 vs. 31.1%) compared with medium grind size by increasing the rate of starch degradation by 105% (19.5 vs. 9.5%/h) with no effect on rate of starch passage. However, total-tract starch digestibility was not affected by fineness of grind because postruminal starch digestibility was 37% greater for medium compared with fine grind size (57.2 vs. 41.9% of starch intake). Endosperm type did not affect flow of nitrogen (N) fractions to the duodenum or microbial N efficiency, whereas fine grind size increased duodenal flow of nonammonia N by increasing duodenal flow of microbial N by 22% compared with medium grind size (438 vs. 359 g/d) but did not affect apparent total-tract N digestibility. No interactions were detected for any measure of starch digestion, ruminal N metabolism, or flow of N fractions to the duodenum. Endosperm type greatly affected ruminal and total-tract starch digestibility independent of the fineness of grind of corn grain with no effects on flow of N fractions. [ABSTRACT FROM AUTHOR]

Our objective was to evaluate effects of corn grain endosperm type and fineness of grind on feed intake, feeding behavior, ruminal fermentation, and productive performance of lactating cows. Eight ruminally and duodenally cannulated Holstein cows in mid lactation (130 ± 42 d in milk; mean ± standard deviation) were used in a duplicated 4 × 4 Latin square design with 21-d periods. A 2 × 2 factorial arrangement of treatments was used with main effects of corn grain endosperm type (floury or vitreous) and fineness of grind of corn grain (fine or medium). Rations were formulated to contain 29% starch, 27% neutral detergent fiber, 18.2% forage neutral detergent fiber, and 18% crude protein. Corn grain treatments supplied 86.2% of dietary starch. Endosperm was 25% vitreous for floury corn and 66% vitreous for vitreous corn. Fineness of grind did not affect dry matter intake (DMI), but floury corn tended to reduce DMI (23.8 vs. 25.1 kg/d) compared with vitreous corn. Floury corn increased meal frequency more for fine grind size (9.57 vs. 9.41 meals/d) than medium grind size (9.78 vs. 9.75 meals/d). However, there were no effects of treatment on any other measure of feeding behavior. Endosperm type did not affect yields of milk or milk components or milk composition except that vitreous corn tended to decrease milk lactose concentration compared with floury corn. Finely ground corn decreased yields of milk (31.1 vs. 33.1 kg/d), 3.5% fat-corrected milk (33.1 vs. 35.1 kg/d), milk fat (1.22 vs. 1.32 kg/d), milk lactose (1.48 vs. 1.59 kg/d), and solids not fat (2.46 vs. 2.63 kg/d) compared with medium grind size. However, fineness of grind did not affect milk composition. Treatments had no effect on change in body weight or body condition score or efficiency of milk production (kg of 3.5% fat-corrected milk/kg of DMI). Mean ruminal pH was not affected by treatment, but pH variance was decreased by vitreous compared with floury corn. Total volatile fatty acids and propionate concentrations in the rumen were increased by floury compared with vitreous corn but were not affected by fineness of grind. Effects of fineness of grind on yield of milk and milk components were greater than the effects of corn grain vitreousness. [ABSTRACT FROM AUTHOR]

Our objective was to evaluate the relative effects of endosperm type and conservation method of corn grain on ruminal kinetics, site of nutrient digestion, and flow of nitrogen fractions to the duodenum in lactating dairy cows. Seven ruminally and duodenally cannulated Holstein cows (73 ± 39 d in milk; mean ± SD) were used in a duplicated 4 × 4 Latin square design with 21-d periods. A 2 × 2 factorial arrangement of treatments was used, with main effects of corn grain endosperm type (floury or vitreous) and conserved as dry ground corn (DGC) or high-moisture corn (HMC). Rations were formulated to contain 27.0% starch, 26.6% neutral detergent fiber (NDF), 19.1% forage NDF, and 16.5% crude protein. Corn grain treatments supplied 86.6% of dietary starch, and alfalfa silage was the sole forage. True ruminal starch digestibility was increased by HMC compared with DGC (87.2 vs. 64.3%) and by floury compared with vitreous corn grain (83.7 vs. 67.7%). The increase for HMC compared with DGC was because of an increase in the degradation rate (33.8 vs. 23.1%/h) and a decrease in passage rate of starch (7.6 vs. 15.2%/h). The increase for floury compared with vitreous corn grain was because of an increase in the degradation rate (31.5 vs. 25.4%/h) and a decrease in rate of starch passage from the rumen (7.9 vs. 14.9%/h). Apparent total-tract starch digestibility was increased by HMC compared with DGC and by floury compared with vitreous corn, but the increase for floury corn was greater for the DGC treatment. Dry ground corn compared with HMC tended to increase nonammonia N flow to the duodenum (466 vs. 431 g/d) by increasing flow of nonammonia nonmicrobial N (211 vs. 111 g/d) despite a decrease in microbial N flow (255 vs. 320 g/d). Vitreous corn increased nonammonia nonmicrobial N flow to the duodenum (187 vs. 135 g/d) compared with floury corn, but microbial N flow to the duodenum was not affected by endosperm type. Efficiency of microbial N production was not affected by treatment. Endosperm type and conservation method of corn grain greatly affect digestion kinetics and ruminal digestibility of starch as well as flow of N fractions to the duodenum and should be considered during diet formulation for lactating cows. [ABSTRACT FROM AUTHOR]

Our objective was to evaluate the effects of corn grain varying in endosperm type and conserved as high-moisture or dry ground corn on dry matter intake (DMI), feeding behavior, ruminal fermentation, and yields of milk and milk components of cows in early to mid-lactation. Seven ruminally and duodenally cannulated Holstein cows (73 ± 39 d in milk; mean ± SD) were used in a duplicated 4 × 4 Latin square design with 21-d periods. A 2 × 2 factorial arrangement of treatments was used with main effects of corn grain endosperm type (floury or vitreous) conserved as high-moisture corn (HMC) or dry ground corn (DGC). Rations were formulated to contain 27.0% starch, 26.6% neutral detergent fiber (NDF), 19.1% forage NDF, and 16.5% crude protein. Corn grain treatments supplied 86.6% of dietary starch and contained alfalfa silage as the sole forage. Dry matter intake was increased 1.3 kg/d by DGC compared with HMC. The increase in DMI by DGC was related to a shorter intermeal interval (104.4 vs. 118.2 min/d), and meal size was not affected by treatment. Dry ground corn decreased rumination bout length and number of chews per bout compared with HMC. No differences were detected between endosperm treatments for DMI, yields of milk, 3.5% fat-corrected milk (FCM), milk fat, protein, lactose, or solids-not-fat (SNF). Mean yield of 3.5% FCM across treatments was 47.5 kg/d. However, a tendency for an interaction was observed for feed efficiency; floury endosperm increased efficiency 0.05 kg 3.5% FCM per kg of DMI for DGC but decreased it by 0.14 kg 3.5% FCM per kg of DMI for HMC relative to vitreous endosperm. Vitreous compared with floury corn tended to increase true protein concentration in milk when conserved as DGC (2.68% vs. 2.62%) but not as HMC. Concentration of SNF was increased by DGC compared with HMC (8.45 vs. 8.37%) due, in part, to the effect of treatment on milk protein concentration. Body weight was not affected by treatment, but vitreous endosperm tended to increase loss of body condition compared with floury endosperm. Corn endosperm type and conservation method had little effect on productive performance of high-producing cows. [ABSTRACT FROM AUTHOR]

Spatial synchrony, defined as the correlated fluctuations in abundance of spatially separated populations, can be caused by regional fluctuations in natural and anthropogenic environmental population drivers. Investigations into the geography of synchrony can provide useful insight to inform conservation planning efforts by revealing regions of common population drivers and metapopulation extinction vulnerability. We examined the geography of spatial synchrony and decadal changes in these patterns for grassland birds in the United States and Canada, which are experiencing widespread and persistent population declines. We used Bayesian hierarchical models and over 50 years of abundance data from the North American Breeding Bird Survey to generate population indices within a 2° latitude by 2° longitude grid. We computed and mapped mean local spatial synchrony for each cell (mean detrended correlation of the index among neighboring cells), along with associated uncertainty, for 19 species in 2, 26‐year periods, 1968–1993 and 1994–2019. Grassland birds were predicted to increase in spatial synchrony where agricultural intensification, climate change, or interactions between the 2 increased. We found no evidence of an overall increase in synchrony among grassland bird species. However, based on the geography of these changes, there was considerable spatial heterogeneity within species. Averaging across species, we identified clusters of increasing spatial synchrony in the Prairie Pothole and Shortgrass Prairie regions and a region of decreasing spatial synchrony in the eastern United States. Our approach has the potential to inform continental‐scale conservation planning by adding an additional layer of relevant information to species status assessments and spatial prioritization of policy and management actions. Our work adds to a growing literature suggesting that global change may result in shifting patterns of spatial synchrony in population dynamics across taxa with broad implications for biodiversity conservation. [ABSTRACT FROM AUTHOR]

Building resilience to flooding is a commitment of several universities; however, student interest in flood education programs is unclear. The goals of this research are three‐fold: 1) to determine the origin of flood messaging on the Old Dominion University (ODU) campus, 2) to assess on‐campus flood awareness, and 3) to evaluate the interest in additional flood education. This study evaluates student awareness of flooding via a survey of ODU students and contextual analysis of University warning messages. Many students experienced reduced access to campus as a result of flooding and expressed an interest in additional flood information. Some students reported receiving flood‐related information through in‐class instruction or orientation‐based programming. However, the content varies in detail, and ODU could formally integrate additional resources into outreach and flood education programming. These findings could support the development of a campus wide flood awareness program at ODU and other universities. [ABSTRACT FROM AUTHOR]

Aim: Hospital admissions secondary to immune‐related adverse events (irAE) arising from immune checkpoint inhibitors (ICI) are likely to increase with increasing use of this class of drug. We sought to determine the characteristics and outcomes of hospital admissions due to irAE. Methods: A retrospective analysis of patients treated with ICI at two tertiary hospitals in Queensland (Australia) was performed. Patients who received at least one dose of ICI for a nonhaematological malignancy between the 1st January 2016 and 1st January 2017 were included. All subsequent hospital admissions were analyzed. Results: A total of 140 patients were included, with the most common malignancies being non‐small‐cell‐cell lung cancer (41%) and melanoma (18%), and most patients received anti‐PD1 treatment (78%). A sum of 76 patients accounted for 116 admissions. Comparing admissions due to irAE and non‐irAE, those admitted for irAE had a significantly longer duration on ICI prior to admission (173 vs 105 days, P = 0.04) but durations of admissions were similar (9.0 vs 8.5 days, P = 0.85). Fifteen patients (11% overall cohort) accounted for 18 admissions attributable to 16 separate irAE. irAE was not considered as a differential diagnosis on admission in 7 patients (38%). In those patients, commencement of corticosteroids was delayed (1.5 days, P = 0.01) but this did not translate into adverse outcomes such as prolonged admissions, prolonged steroid use or long‐term complications. All patients with irAE were managed with high‐dose corticosteroids. One death resulted from irAE (pneumonitis). Conclusions: A sum of 11% patients receiving ICI required hospital admission for irAE. The relatively high rate of irAE as a missed differential diagnosis on admission suggests a need for improved cross‐discipline awareness, education, and institutional management guidelines. [ABSTRACT FROM AUTHOR]

'Care' is a term that hunters increasingly apply to diverse practices pertaining to their interactions with wildlife. In this article, we investigated the extent and durability of hunters' use of care language, including appeals made to sentiment, relation, compassion, embodiedness and situated morality. After establishing the use of such language in contemporary hunting media, we discuss two case studies of contemporary sport hunting that tease out dimensions of care. These case studies show how hunters' appeal to care is deeply problematic and oppositely, how these hunting forms bring out new relations and scopes of care with wildlife unanticipated by critics. Without discounting hunters' sincerity, we note that hunters may use this language opportunistically rather than with consistent philosophical appeal. We conclude by discussing the possible role of hunters' appeal to care language in mediating public acceptance of hunting. [ABSTRACT FROM AUTHOR]

Efforts to monitor and conserve populations and ecosystems in human‐dominated landscapes can benefit from an empirical social–ecological systems approach.Here we illustrate how latent variable structural equation modelling of regional time series data can effectively describe interconnected drivers of population fluctuations in dynamic landscapes and can help to reveal previously unknown system drivers.Using a declining farmland‐dependent bird species (Ammodramus savannarum) in the eastern United States (1994–2015) as a case study, our analysis reveals how farm management decisions drive population fluctuations (R2 = 20%), while management is in turn highly influenced by climate (R2 = 23%–51%), but not by regional conservation spending.Synthesis and applications. Structural equation modelling revealed potential social–ecological pathways for halting regional population declines in a grassland bird, the Grasshopper Sparrow. Lower population growth rates followed years of higher hay yields (~4 percentage points per metric ton increase in hay yield) and later harvests (~2 percentage points per 10‐day delay in harvest). Thus, one pathway for stabilising regional populations could involve compensating farmers for reducing hay harvests, potentially requiring a six‐fold increase in current annual agri‐environmental conservation spending. [ABSTRACT FROM AUTHOR]

Indeed, the book explains how we use a whole range of experimental techniques, as well as the detailed information generated by molecular dynamics and Monte Carlo simulations, to understand how and why molecules form mesophases, how they are arranged, and how they move. This impressive book gives a comprehensive account of the science of liquid crystals, from the microscopic, molecular, viewpoint. The most important phase transitions in thermotropic liquid crystals are described; then more briefly lyotropic systems are discussed. [Extracted from the article]

In 1987, Margaret Thatcher said 'there is no such thing as society'. If the classic Bildungsroman moves toward integration into the social order, how does the genre register the British 1980s' valorisation of autonomy over solidarity? The plots of what I call the Thatcherite Bildungsroman exploit the unstable marriage between traditionalist 'Victorian Values' and transformative 'creative destruction'. The Thatcherite ideal of self-development through market labour seems to depend upon the family unit to stabilize the social order. However, the drive toward autonomy that Thatcherism championed undermined the unity of the family. The divorce plot replaces the marriage plot in these books because the novel of self-development cannot help asking whether the atomic unit of the social order is the family or the individual. In David Mitchell's Black Swan Green, the divorce plot – the novel begins with a mysterious female caller and ends by dispersing the household – allows the teenage protagonist to understand 'creative destruction' as self-development. In contrast, the abortive divorce plot in Alan Hollinghurst's The Line of Beauty – in which the gay protagonist is sacrificially expelled from a heterosexual nuclear family – manifests a homophobic paranoia about what a 1987 Act of Parliament called 'homosexuality as a pretended family relationship'. [ABSTRACT FROM AUTHOR]

In many times and various ways, some significant Reformed theologians have claimed that biblical theology must be coordinated with or contribute to the task of systematic theology. In these last days, they have even suggested that biblical theology should fill the place of systematic theology. Part One described the way in which Geerhardus Vos, John Murray, and Richard Gaffin have addressed the role of biblical theology in relation to systematic theology and analyzed their arguments. This essay will offer counterproposals regarding the origin, mainstreaming, and end of biblical theology (and theological interpretation of scripture) as exegetical therapies meant to serve the functioning of dogmatics and exegesis. [ABSTRACT FROM AUTHOR]

This study presents two simulation modelling tools to support the organisation of networks of dialysis services during the COVID-19 pandemic. These tools were developed to support renal services in the South of England (the Wessex region caring for 650 dialysis patients), but are applicable elsewhere. A discrete-event simulation was used to model a worst case spread of COVID-19, to stress-test plans for dialysis provision throughout the COVID-19 outbreak. We investigated the ability of the system to manage the mix of COVID-19 positive and negative patients, the likely effects on patients, outpatient workloads across all units, and inpatient workload at the centralised COVID-positive inpatient unit. A second Monte-Carlo vehicle routing model estimated the feasibility of patient transport plans. If current outpatient capacity is maintained there is sufficient capacity in the South of England to keep COVID-19 negative/recovered and positive patients in separate sessions, but rapid reallocation of patients may be needed. Outpatient COVID-19 cases will spillover to a secondary site while other sites will experience a reduction in workload. The primary site chosen to manage infected patients will experience a significant increase in outpatients and inpatients. At the peak of infection, it is predicted there will be up to 140 COVID-19 positive patients with 40 to 90 of these as inpatients, likely breaching current inpatient capacity. Patient transport services will also come under considerable pressure. If patient transport operates on a policy of one positive patient at a time, and two-way transport is needed, a likely scenario estimates 80 ambulance drive time hours per day (not including fixed drop-off and ambulance cleaning times). Relaxing policies on individual patient transport to 2-4 patients per trip can save 40-60% of drive time. In mixed urban/rural geographies steps may need to be taken to temporarily accommodate renal COVID-19 positive patients closer to treatment facilities. [ABSTRACT FROM AUTHOR]

A recent issue of Topics in Cognitive Science featured 11 thoughtful commentaries responding to our article "What happened to cognitive science?" (Núñez et al., 2019). Here, we identify several themes that arose in those commentaries and respond to each. Crucial to understanding our original article is the fundamental distinction between multidisciplinary and interdisciplinary endeavors: Cognitive science began (and has stayed) as multidisciplinary but has failed to move on to form a cohesive interdisciplinary field. We clarify and elaborate our original argument and reiterate the importance of a data‐driven evaluation of the current status of the field, which exhibits a marked disciplinary imbalance, a lack of a coherent conceptual core, and a striking absence of a consistent curriculum in the institutions that grant degrees in this domain. Half a century after the creation of cognitive science, it may now be a good time to revisit goals and visions for how to best approach the ever‐fascinating scientific study of the mind(s). [ABSTRACT FROM AUTHOR]

How do citizens within countries hosting U.S. military personnel view that presence? Using new cross-national survey data from 14 countries, we examine how different forms of exposure to a U.S. military presence in a country affect attitudes toward the U.S. military, government, and people. We find that contact with U.S. military personnel or the receipt of economic benefits from the U.S. presence correlates with stronger support for the U.S. presence, people, and government. This study has profound implications for the role that U.S. installations play in affecting the social fabric of host nations and policy implications for the conduct of U.S. military activities outside the United States. [ABSTRACT FROM AUTHOR]

Background: The Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain (COG) was developed in response to increasing rates of opioid-related hospital visits and deaths in Canada, and uncertain benefits of opioids for chronic non-cancer pain (CNCP). Following publication, we developed a list of evaluable outcomes to assess the impact of this guideline on practice and patient outcomes. Methods: A working group at the National Pain Centre at McMaster University used a modified Delphi process to construct a list of clinical and patient outcomes important in assessing the uptake and application of the COG. An advisory group then reviewed this list to determine the relevance and feasibility of each outcome, and identified potential data sources. This feedback was reviewed by the National Faculty for the Guideline, and a National Advisory Group that included the creators of the COG, resulting in the final list of 5 priority outcomes. Results: Five outcomes were judged clinically important and feasible to measure: 1) Effects of opioids for CNCP on quality of life, 2) Assessment of patient's risk of addiction before starting opioid therapy, 3) Monitoring patients on opioid therapy for aberrant drug-related behaviour, 4) Mortality rates associated with prescription opioid overdose and 5) Use of treatment agreements with patients before initiating opioid therapy for CNCP. Data sources for these outcomes included patient's medical charts, e-Opioid Manager, prescription monitoring programs and administrative databases. Conclusion: Measuring the impact of best practice guidelines is infrequently done. Future research should consider capturing the five outcomes identified in this study to evaluate the impact of the COG in promoting evidence-based use of opioids for CNCP. [ABSTRACT FROM AUTHOR]

Debates about the definitions of and relationship between systematic theology and biblical theology have become commonplace. Institutional and intellectual programs have taken sides and stood over against each other. Even within the relatively small world of confessional Reformed theology, the matter has garnered a good bit of attention and controversy. Matters have only grown more complex with the rise, more recently, of theological interpretation of scripture or theological exegesis, which may or may not overlap with both systematics and biblical theology. This essay seeks to reflect on perhaps the most influential proposals thus far and then to suggest a way forward. To that end, proposals by Geerhardus Vos, John Murray, and Richard Gaffin will be examined at length. In each case, their argument will be traced patiently, with observations and questions raised in a preliminary manner. Deeper analysis and a counterproposal will appear in a second essay. [ABSTRACT FROM AUTHOR]

Background: Macrophages show versatile functions in innate immunity, infectious diseases, and progression of cancers and cardiovascular diseases. These versatile functions of macrophages are conducted by different macrophage phenotypes classified as classically activated macrophages and alternatively activated macrophages due to different stimuli in the complex in vivo cytokine environment. Dissecting the regulation of macrophage activations will have a significant impact on disease progression and therapeutic strategy. Mathematical modeling of macrophage activation can improve the understanding of this biological process through quantitative analysis and provide guidance to facilitate future experimental design. However, few results have been reported for a complete model of macrophage activation patterns. Results: We globally searched and reviewed literature for macrophage activation from PubMed databases and screened the published experimental results. Temporal in vitro macrophage cytokine expression profiles from published results were selected to establish Boolean network models for macrophage activation patterns in response to three different stimuli. A combination of modeling methods including clustering, binarization, linear programming (LP), Boolean function determination, and semi-tensor product was applied to establish Boolean networks to quantify three macrophage activation patterns. The structure of the networks was confirmed based on protein-protein-interaction databases, pathway databases, and published experimental results. Computational predictions of the network evolution were compared against real experimental results to validate the effectiveness of the Boolean network models. Conclusion: Three macrophage activation core evolution maps were established based on the Boolean networks using Matlab. Cytokine signatures of macrophage activation patterns were identified, providing a possible determination of macrophage activations using extracellular cytokine measurements. [ABSTRACT FROM AUTHOR]

In all biorefinery systems, excess water represents a key challenge, and its removal by drying is often a necessary and crucial pre‐treatment. Second‐generation feedstocks have often fallen at this hurdle, particularly microalgae‐derived biomasses, which require extensive (and costly) dewatering. Hydrothermal liquefaction (HTL) has gained increasing attention in recent years as a technology that uses the water present in the feedstock as a versatile reaction medium, which functions as a solvent, reactant, and catalyst for a cascade of organic reactions. Converting organic biomasses into oil, aqueous, solid, and gas fractions, the development of HTL provides the opportunity to exploit previously unsuitable biomasses in a versatile bio‐refinery approach. Marine macroalgae (seaweeds) offer a sustainable source of renewable biomass, which require no land or freshwater to cultivate or harvest. With 70% of the surface of the planet covered in seawater and levels of eutrophication increasing, seaweeds are an underutilized resource with excellent potential for relieving the pressure on fossil resources. Hitherto, this exploitation has been hindered by a lack of suitable and economical processing tools. Here we review the potential for applying HTL to processing marine macroalgae and discuss the potential products and services that can be derived from this potential biorefinery system. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Ruminal microbes partially degrade dietary protein and synthesise microbial protein, which, along with undegraded true protein, contributes to metabolisable protein for the animal. Rumen models have been developed over the past several decades in an effort to better predict metabolisable protein supply for ration formulation for ruminants. These models have both empirical and mechanistic components. Separation of dietary protein into fractions that include non-protein nitrogen, true protein and unavailable protein has been a fundamental element of these models. Ruminal degradation of one or more true protein fractions is then estimated on the basis of the kinetics of digestion and passage. Some models use the same method to predict substrate supply for microbial protein production. Although mechanistic models have been extensively used in diet-formulation programs worldwide, their ability to improve accuracy of prediction of metabolisable protein over simpler empirical models is questionable. This article will address the potential of mechanistic models to better predict metabolisable protein supply in ruminants as well as their limitations. Metabolisable protein in ruminants is derived from dietary protein that is not degraded in the rumen and protein synthesised by rumen microbes that passes to the duodenum. Mechanistic rumen models have been developed in an attempt to improve the prediction of metabolisable protein for ration formulation. These models are more complex than are simple empirical models and their accuracy is limited by the availability of data to parameterise them. This article discusses the limitations of mechanistic models for the prediction of metabolisable protein in ruminants. [ABSTRACT FROM AUTHOR]

Our objective was to determine the effects of uncouplers of oxidative phosphorylation on feeding behavior of lactating dairy cows. We hypothesized that uncouplers of oxidative phosphorylation would increase meal size and meal length and performed 2 experiments to test our hypothesis. In experiment 1, 4 late-lactation cows (345 ± 48.4 d in milk; mean ± SD) were administered a daily intrajugular injection of either 10 mg/kg of BW0.75 of 2,4-dinitrophenol methyl ether (DNPME) and propylene carbonate or propylene carbonate (control; CON) in a crossover design with 2-d periods. In experiment 2, 8 early-lactation cows (11.3 ± 0.89 d in milk) were administered a daily intrajugular injection via jugular catheter of either 50 mg/kg of BW of sodium salicylate (SAL) and saline or saline (control; CON) in a crossover design with 1-d periods. Feeding behavior was recorded by a computerized data acquisition system and analyzed for the first 4 h after access to feed within 15 min of treatment for both experiments. Neither DNPME nor SAL affected meal size over the first 4 h after access to feed. However, DNPME increased meal length by 6.4 min (26.3 vs. 19.9 min) and tended to decrease the number of meals (2.55 vs. 2.78 meals/4 h) over the first 4 h after access to feed compared with CON. Both DNPME and SAL decreased eating rate over the first 4 h after access to feed compared with their respective controls (0.10 vs. 0.12 kg/min for DNPME vs. CON; 0.06 vs. 0.07 kg/min for SAL vs. CON). Lack of treatment effects on meal size may have been caused by increased rate of oxidation of fuels compensating for the disruption of oxidative phosphorylation. [ABSTRACT FROM AUTHOR]

Marine macroalgae (seaweed) has many advantages over terrestrial crops as a source of renewable biomass but is severely underutilised at present, especially within Europe. In particular, macroalgae has elevated poly- and monosaccharide content, making it an ideal feedstock as a heterotrophic fermentation sugar source for the production of higher value chemicals. Recent reports have detailed the suitability of seaweeds as a feedstock for the production of single-cell oils (SCOs) which have application in food, oleochemicals and fuels. It is proposed that a biorefinery system based on the production of SCOs alongside other secondary metabolites, has the potential to provide a sustainable replacement to terrestrial oils such as palm oil. This work therefore evaluates, for the first time, the environmental and economic sustainability of a production process for SCOs from seaweed Saccharina latissima using the oleaginous yeast Metschnikowia pulcherrima. Two alternative fermentation systems were considered, and uncertainties associated with the seasonal variation in seaweed carbohydrate yield and fermentation performance were integrated into the analysis. From an environmental perspective, the work indicates that seaweed derived SCO lipids and fats can be comparable to a terrestrial oil mix, with a potential climate change impact ranging between 2.5 and 9.9 kg CO 2 eq. kg−1 refined SCO. Interestingly and of particular significance, environmental impacts are mainly dominated by energy demand within fermentation and upstream processing steps. From an economic perspective, a break-even selling price for the oil was determined as between €5,300-€31,000 tonne−1 refined SCO, which was highly dependent on cost of the seaweed feedstock. Overall, we demonstrate that key uncertainties relating to seaweed cultivation costs and hydrolysate fermentation at scale result in a large range in values for environmental impact and economic return on investment. Yet even within the constraints and limitations of current knowhow, seaweed already offers a viable proposition for the competitive production of exotic oils similar to cocoa or shea butter in price and nature. • LCA and economic analysis of SCOs derived from seaweed Saccharina latissima performed for the first time. • Climate change impact for process determined to be between 2.5 and 9.9 kg CO 2 eq. kg−1 refined SCO. • Break-even selling price for the oil calculated as between €5,300-€31,000 tonne−1 refined SCO. • Climate change impacts within the range of what has previously been quoted for microalgae and terrestrial oil mixes. • Lower-end break-even pricing is closer to that of exotic oils and fats than terrestrial oils like palm oil. [ABSTRACT FROM AUTHOR]