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4. Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

Author

Sjoberg, Hanna T., Philippou, Yiannis, Magnussen, Anette L., Tullis, Iain D. C., Bridges, Esther, Chatrian, Andrea, Lefebvre, Joel, Tam, Ka Ho, Murphy, Emma A., Rittscher, Jens, Preise, Dina, Agemy, Lilach, Yechezkel, Tamar, Smart, Sean C., Kinchesh, Paul, Gilchrist, Stuart, Allen, Danny P., Scheiblin, David A., Lockett, Stephen J., Wink, David A., Lamb, Alastair D., Mills, Ian G., Harris, Adrian, Muschel, Ruth J., Vojnovic, Boris, Scherz, Avigdor, Hamdy, Freddie C., and Bryant, Richard J.

Published
2021
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11. Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models

Author

Kaeppler, Jakob R, primary, Chen, Jianzhou, additional, Buono, Mario, additional, Vermeer, Jenny, additional, Kannan, Pavitra, additional, Cheng, Wei‐Chen, additional, Voukantsis, Dimitrios, additional, Thompson, James M, additional, Hill, Mark A, additional, Allen, Danny, additional, Gomes, Ana, additional, Kersemans, Veerle, additional, Kinchesh, Paul, additional, Smart, Sean, additional, Buffa, Francesca, additional, Nerlov, Claus, additional, Muschel, Ruth J, additional, and Markelc, Bostjan, additional

Published
2022
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13. NLS Data Entry Quality Control: The Fourth Follow-Up Survey.

Author

Research Triangle Inst., Durham, NC. Center for Educational Research and Evaluation., Henderson, Louise B., and Allen, Danny R.

Abstract

The data entry quality control procedures in discrete data entry tasks in the National Longitudinal Study (NLS) Fourth Follow-Up Survey are examined. Direct data entry terminals were used to key survey questionnaire item responses, telephone interview corrections, respondent background information and supplemental questionnaire responses into computer disk storage. Data entry error rates were computed on the survey questionnaires by selecting a random sample from each batch after initial keying of the data, rekeying the selected questionnaires by two additional operators and determing error rates on the basis of three keyings. In the implementation described, the overall error rate tolerance established for the NLS survey was not exceeded. The variable error rate over samples and operators on the selected supplemental questionnaires was 0.00040; estimated character error rate was 0.00023. The telephone interview additions and corrections, and directory information entry procedures are described. (CM)

Published
1981

15. Protease nexin 1 inhibits Hedgehog signaling in prostate adenocarcinoma

Author

McKee, Chad M., Xu, Danmei, Cao, Yunhong, Kabraji, Sheheryar, Allen, Danny, Kersemans, Veerle, Beech, John, Smart, Sean, Hamdy, Freddie, Ishkanian, Adrian, Sykes, Jenna, Pintile, Melania, Milosevic, Michael, Kwast, Theodorus van der, Zafarana, Gaetano, Ramnarine, Varune Rohan, Jurisica, Igor, Mallof, Chad, Lam, Wan, Bristow, Robert G., and Muschel, Ruth J.

Subjects
Prostate cancer -- Diagnosis -- Care and treatment, Proteases -- Properties, Adenocarcinoma -- Diagnosis -- Care and treatment, Hedgehog proteins -- Properties, Cellular signal transduction -- Genetic aspects, Health care industry
Abstract

Prostate adenocarcinoma (CaP) patients are classified into low-, intermediate-, and high-risk groups that reflect relative survival categories. While there are accepted treatment regimens for low- and high-risk patients, intermediate-risk patients pose a clinical dilemma, as treatment outcomes are highly variable for these individuals. A better understanding of the factors that regulate the progression of CaP is required to delineate risk. For example, aberrant activation of the Hedgehog (Hh) pathway is implicated in CaP progression. Here, we identify the serine protease inhibitor protease nexin 1 (PN1) as a negative regulator of Hh signaling in prostate. Using human CaP cell lines and a mouse xenograft model of CaP, we demonstrate that PN1 regulates Hh signaling by decreasing protein levels of the Hh ligand Sonic (SHH) and its downstream effectors. Further-more, we show that SHH expression enhanced tumor growth while overexpression of PN1 inhibited tumor growth and angiogenesis in mice. Finally, using comparative genome hybridization, we found that genetic alterations in Hh pathway genes correlated with worse clinical outcomes in intermediate-risk CaP patients, indicating the importance of this pathway in CaP., Introduction Prostate adenocarcinoma (CaP) is the second leading cause of male cancer death in the Western world (1). Various risk groups (low, intermediate, high, and metastatic) that reflect relative survival [...]

Published
2012
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17. Tumor irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumor effects in preclinical prostate cancer

Author

Sjoberg, Hanna T, primary, Philippou, Yiannis, additional, Magnussen, Anette L, additional, Tullis, Iain DC, additional, Bridges, Esther, additional, Chatrian, Andrea, additional, Loefebvre, Joel, additional, Tam, Ka Ho, additional, Murphy, Emma A, additional, Rittscher, Jens, additional, Preise, Dina, additional, Agemy, Lilach, additional, Yechezkel, Tamar, additional, Smart, Sean C, additional, Kinchesh, Paul, additional, Gilchrist, Stuart, additional, Allen, Danny P, additional, Scheiblin, David A, additional, Lockett, Stephen J, additional, Wink, David A, additional, Lamb, Alastair D, additional, Mills, Ian G, additional, Harris, Adrian, additional, Muschel, Ruth J, additional, Vojnovic, Boris, additional, Scherz, Avigdor, additional, Hamdy, Freddie C, additional, and Bryant, Richard J, additional

Published
2020
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19. Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3

Author

Lauder, Sarah Nicol, primary, Smart, Kathryn, additional, Kersemans, Veerle, additional, Allen, Danny, additional, Scott, Jake, additional, Pires, Ana, additional, Milutinovic, Stefan, additional, Somerville, Michelle, additional, Smart, Sean, additional, Kinchesh, Paul, additional, Lopez-Guadamillas, Elena, additional, Hughes, Ellyn, additional, Jones, Emma, additional, Scurr, Martin, additional, Godkin, Andrew, additional, Friedman, Lori S, additional, Vanhaesebroeck, Bart, additional, and Gallimore, Awen, additional

Published
2020
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20. Abstract B30: Assessment of CCR5i/maraviroc immunotherapy in combination with PD1 and MR-guided radiotherapy for treatment of pancreatic cancer

Author

Lanfredini, Simone, primary, Hughes, Sophie, additional, Thapa, Asmita, additional, Bangs, Fiona, additional, Morton, Jennifer, additional, Allen, Danny, additional, Kersemans, Veerle, additional, Kinchesh, Paul, additional, Smart, Sean, additional, Elliot, Amy, additional, Thompson, James, additional, Hill, Mark, additional, Mukherjee, Somnath, additional, and O'Neill, Eric, additional

Published
2019
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21. All-in-one PCs with a touch of style: power, good looks, cool touch interfaces: all-in-one PCs have come of age. Our exclusive lab testing picks the best of breed

Author

Allen, Danny and Murphy, David

Subjects
Lenovo IdeaCentre A600 (Special-purpose computer system), Sony VAIO VGC-LV180J (Special-purpose computer system), HP TouchSmart IQ816 (Special-purpose computer system), Microcomputers -- Product/service Evaluations
Abstract

PCW Test Center We'll say it up front: The iMac is no longer the final word in all-in-one PCs. Though Apple's latest aluminum iMacs were the performance champs in our […]

Published
2009

22. The Best bargain PCs: basic laptops and desktops have never been less expensive, but are you giving up too much if you go cheap? We tested 12 low-cost machines to find the real values

Author

Thornton, Carla, Jantz, Richard, and Allen, Danny

Subjects
Semiconductor industry, Software/hardware leasing, Keyboard accessory, Microcomputer industry, Computer industry, Keyboard, Intel Corp., Compaq Computer Corp., Semiconductor industry, Keyboards (Electronics) -- Evaluation, Computers -- Evaluation, Computer industry
Abstract

BUYING A COMPUTER is always an exercise in compromise. When you're deciding whether a budget-priced PC will match your power and expandability needs, the answer depends on how many concessions […]

Published
2008

24. The wide world of monitors: we brought 17 flat screen LCDs--from the wide to the double-wide to the ultrawide--into the PCW Test Center. Whether you want to see more work or more movie, we have product recommendations and shopping tips for you

Author

Allen, Danny

Subjects
LCD display, Liquid crystal displays -- Product/service Evaluations
Abstract

Everyone needs a good monitor (or two) to get the most out of a PC. But finding the right model depends on several factors: what applications you use, how much […]

Published
2008

25. Talk is cheap: did you know that broadband gives you the potential to make cheap and sometimes free phone calls? It's easier than you think! PC World shows you how to get started and what the (realistic) cost savings and hardware options are. Plus, we road test five of the latest services

Author

Allen, Danny

Subjects
Australia
Abstract

What is VoIP? VoIP (Voice over Internet protocol) services providing 'Internet telephony' can save money because you use an Internet connection to carry voice calls rather than the regular public […]

Published
2005

26. Centrino evolves: two years after it launched the Centrino mobile computing platform, Intel has released new technology in the form of Sonoma. But is the update a revolution or an evolution? We put 10 of these latest portable performers to the test to judge the nature of the beast

Author

Allen, Danny

Subjects
Semiconductor industry, Consumer electronics industry, Microcomputer industry, Computer industry, International Business Machines Corp., Toshiba Corp., Intel Corp., Consumer electronics industry, Semiconductor industry, Computer industry
Abstract

The original Centrino platform helped foster smaller and lighter notebooks with standardised wireless networking options. Although it's not like you couldn't wirelessly network a notebook before Centrino, Intel's marketing blitz […]

Published
2005

29. Sub-$3000. (Best Buys)

Author

Allen, Danny

Subjects
Semiconductor industry, Intel Corp., Semiconductor industry
Abstract

Twinhead Efio 2617 [1] NEW This notebook is actually the same chassis and model type as the Hi-Grade Notino R5400 in the $3001-$6000 charts, as Twinhead is the manufacturer of […]

Published
2003

30. Community services versus crisis resolution teams: Danny Allen reviews the literature on the subject and draws on his experiences to examine what works best for patients

Author

Allen, Danny

Subjects
Community psychiatric services -- Services -- Social aspects, Medical care -- Quality management, Mental illness -- Care and treatment, Company business management, Health, Health care industry, Psychology and mental health
Abstract

Summary Crisis resolution and home treatment teams were set up across the UK as part of the NHS Plan (Department of Health 2000), Ten years on, the evidence base for [...]

Published
2010

32. Notebooks. (best buys)

Author

Allen, Danny

Abstract

OVER $6000 1 Dell Latitude C400 The C400's Intel Pentium III-M 1.2GHz processor coupled with 128MB of RAM achieved a PC WorldBench 4 score of 102 and a SYSMark 2001 […]

Published
2002

33. Notebooks. (Best Buys Notebooks)

Author

Allen, Danny

Abstract

OVER $6000 1 IBM ThinkPad A30p The A series of ThinkPad notebooks has been designed as desktop PC replacements. This is IBM's attempt to provide an affordable alternative to the […]

Published
2002

34. Notebooks: best buys. (Best Buys Notebooks)

Author

Allen, Danny

Abstract

OVER $6000 1 IBM ThinkPad A30p NEW The A series of ThinkPad notebooks has been designed as desktop PC replacements. This is IBM's attempt to provide an affordable alternative to […]

Published
2002

35. MP3 players. (best buys)

Author

Allen, Danny and Plastiras, Elias

Abstract

Ahh, it's the time of the year when many start to think about gifts, gizmos, grog and unfulfilled fitness resolutions. While not able to help with hangovers, MP3 players can […]

Published
2001

36. Best buys: notebooks. (Best Buys Notebooks)

Author

Allen, Danny

Abstract

1 Dell Inspiron 8000 Within the dark grey casing of the 8000 is a PIII 1GHz, 128MB of RAM, 32MB DDR SDRAM NVIDIA GeForce2 Go video controller, ESS Maestro 3 […]

Published
2001

37. Over $200. (Best Buys Webcams)

Author

Allen, Danny

Abstract

Creative WebCam G0 Plus ES PROS: Ease of setup, functional and comprehensive software package, great storage CONS: No built-in or bundled microphone At the top of Creative's brand-new product line […]

Published
2001

38. Power notebooks. (Best Buys Notebooks)

Author

Hionis, Spiro and Allen, Danny

Abstract

POWER NOTEBOOKS 1 Dell Inspiron 8000 RE-TESTED Within the dark grey casing of the 8000 is a PIII 1GHz, 128MB of RAM, 32MB DDR SDRAM NVIDIA GeForce2 Go video controller, […]

Published
2001

40. Ultrasound-mediated cavitation enhances the delivery of an EGFR-targeting liposomal formulation designed for chemo-radionuclide therapy

Author

Thomas, Eloise, primary, Menon, Jyothi U., additional, Owen, Joshua, additional, Skaripa-Koukelli, Irini, additional, Wallington, Sheena, additional, Gray, Michael, additional, Mannaris, Christophoros, additional, Kersemans, Veerle, additional, Allen, Danny, additional, Kinchesh, Paul, additional, Smart, Sean, additional, Carlisle, Robert, additional, and Vallis, Katherine A., additional

Published
2019
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41. Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture

Author

Jiang, Yanyan, Allen, Danny, Kersemans, Veerle, Devery, Aoife M., Bokobza, Sivan M., Smart, Sean, and Ryan, Anderson J.

Subjects
Pulmonary and Respiratory Medicine, Cancer Research, Lung Neoplasms, Transplantation, Heterologous, Mice, Nude, Tumour vasculature, NSCLC, Article, Mice, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Animals, Humans, skin and connective tissue diseases, Hypoxia, Blood perfusion, Protein Kinase Inhibitors, Cell Proliferation, Mice, Inbred BALB C, Neovascularization, Pathologic, Cediranib, VEGF, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Oncology, Quinazolines, Heterografts, Female
Abstract

Highlights • We studied cediranib, a VEGFR tyrosine kinase inhibitor in lung cancer xenografts. • Gadolinium-enhanced DCE-MRI was used to study acute vascular responses. • Acute vascular response was associated with tumour stromal architecture. • Tumour growth inhibition by cediranib was linked to acute vascular response. • Acute vascular changes are a potential predictive marker of response to cediranib., Objectives Tumours can be categorised based on their stromal architecture into tumour vessel and stromal vessel phenotypes, and the phenotypes have been suggested to define tumour response to chronic treatment with a VEGFR2 antibody. However, it is unclear whether the vascular phenotypes of tumours associate with acute vascular response to VEGFR tyrosine kinase inhibitors (TKI), or whether the early changes in vascular function are associated with subsequent changes in tumour size. This study was sought to address these questions by using xenograft models of human non-small cell lung cancer (NSCLC) representing stromal vessel phenotype (Calu-3) and tumour vessel phenotype (Calu-6), respectively. Methods For dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), nude mice bearing established Calu-3 or Calu-6 xenografts were treated with a potent pan-VEGFR TKI, cediranib (6 mg/kg), at 0 h and 22 h. DCE-MRI was performed 2 h before the first dose and 2 h after the second dose of cediranib to examine acute changes in tumour vessel perfusion. Tumours were harvested for hypoxia detection by CA9 immunohistochemistry. For tumour growth study, mice carrying established Calu-3 or Calu-6 tumours were treated with cediranib once daily for 5 days. Results Twenty-four hours after cediranib administration, the perfusion of Calu-3 tumours was markedly reduced, with a significant increase in hypoxia. In contrast, neither perfusion nor hypoxia was significantly affected in Calu-6 tumours. Tumour regressions were induced in Calu-3 xenografts, but not in Calu-6 xenografts, although there was a trend towards tumour growth inhibition after 5 days of cediranib treatment. Conclusion These findings suggest that tumour stromal architecture may associate with acute tumour vascular response to VEGFR TKI, and this acute tumour vascular response may be a promising early predictive marker of response to VEGFR TKI in NSCLC.

Published
2015

42. Improved outcome of 131 I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma

Author

Corroyer-Dulmont, Aurélien, Falzone, Nadia, Kersemans, Veerle, Thompson, James, Allen, Danny, Able, Sarah, Kartsonaki, Christiana, Malcolm, Javian, Kinchesh, Paul, Hill, Mark, Vojnovic, Boris, Smart, Sean, Gaze, Mark, Vallis, Katherine, University of Oxford [Oxford], Hypoxie, physiopathologies cérébrovasculaire et tumorale (CERVOxy), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre for Cancer Genetic Epidemiology, University of Cambridge [UK] (CAM), Nuffield Department of Population Health [Oxford], University College London Hospitals (UCLH), University of Oxford, Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Neuroblastoma, Radiotherapy, 131I-mIBG, [SCCO.NEUR]Cognitive science/Neuroscience, Image-guided radiotherapy
Abstract

CERVOXY (unité d'origine); International audience

Published
2017

43. Apple's rivals, scramble to make iPad challengers: Dell, HP, and Lenovo are going all out to compete against the Apple iPad tablet PC, in a hot market that could see 50 million units sold by 2015

Author

Allen, Danny

Subjects
Tablet computers -- Supply and demand -- Forecasts and trends -- Product development, Computer industry -- Product development, Tablet computer, Market trend/market analysis, Microcomputer industry, Computer industry, Business, Computers and office automation industries
Abstract

FEW PEOPLE DOUBT that 2010 will go down as the year the tablet computer took off. On April 3, the first day of sales, Apple sold 300,000 iPad tablets to [...]

Published
2010

44. Online video shoot-out: Blip.tv beats YouTube: Scrappy video-sharing rivals offer better quality than YouTube does, and many will share ad revenue with you

Author

Allen, Danny

Subjects
Cable television/data services, Online services, Video-on-demand -- Product/service Evaluations, Online services -- Product/service Evaluations
Abstract

YOUTUBE, NOW owned by Google, may still be the 800-pound gorilla of video sharing sites, but an impressive number of rivals--some merely clones, others offering unique twists--are nipping at its […]

Published
2007

46. $2500-$4000

Author

Allen, Danny

Subjects
Laptop/portable computer, Notebook computers, Laptop computers
Abstract

1 Dell Inspiron 9300 This model included a 17in display with UXGA (1920x1200 pixel resolution) option and a 256MB NVIDIA GeForce Go 6800 graphics controller supplying both VGA- and DVI-external […]

Published
2005

47. Sub-$2500

Author

Allen, Danny

Subjects
Laptop/portable computer, Notebook computers, Laptop computers
Abstract

1 Pioneer DreamBook Slim 805 An original Centrino-branded model, core specifications include Intel's Pentium M processor running at 1.7GHz along with 512MB of DDR SDRAM, a 60GB Hitachi hard disk […]

Published
2005

48. Over $4000

Author

Allen, Danny

Abstract

Toshiba Qosmio G10 [pc world BEST BUYS] [1] The Qosmio G10's (pronounced 'Kozmio') $5999 price tag might seem a lot, but this audiovisual enthusiast's dream machine goes a long way […]

Published
2005

49. Streaming music from the web: you don't have to download MP3 files to enjoy digital music. Audio streaming means you can listen to tunes in real time via a Web connection, but where should you go to find the best music on the Internet? And what software do you need?

Author

Haworth, Rosemary and Allen, Danny

Abstract

The music industry has been a tad slow to embrace online audio, and that's putting it kindly. But it looks as though there may finally be some viable alternatives to […]

Published
2004

50. $2500-$4000

Author

Allen, Danny

Abstract

Dell Inspiron 9100 [pc world BEST BUYS] [1] Billed as the ultimate desktop replacement, the 4.2kg 9100 is certainly geared to infrequent point-to-point use--say, from the office to the home […]

Published
2004

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