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New radiocarbon dates on biological remains from cave deposits in the Canadian Rocky Mountains range in age from infinite to modern but are largely restricted to the Holocene (9560[+ ou -]40 years B.P. to modern). The consistency in radiocarbon ages is interpreted as resulting from geologic processes associated with deglaciation and may reflect timeframes when cave conditions in some areas of the Canadian Rocky Mountains became suitable for deposition and preservation of biological remains. When considered at taxonomic levels permitted by morphological identification, recovered vertebrate remains from cave deposits are consistent with the modern biota of the region, suggesting early post-Late Glacial Maximum establishment of the modern biota and relative stability of mammal assemblages through the Holocene. Preliminary evaluation of recovered plant remains highlights a potentially underevaluated source of palaeoecological data for higher elevations. Key words: Mammalia, chronology, taphonomy, Holocene, Pleistocene De nouveaux âges au radiocarbone sur des restes biologiques provenant de dépôts de caverne dans les Rocheuses canadiennes vont d'infinis à modernes mais sont pour la plupart restreints à l'Holocène (9560[+ ou -]40 années BP à modernes). La cohérence des âges au radiocarbone est interprétée comme étant le résultat de processus géologiques associés à la déglaciation et pourrait refléter des périodes durant lesquelles les conditions dans les cavernes de certains secteurs des Rocheuses canadiennes se prêtaient au dépôt et à la préservation de restes biologiques. Aux niveaux taxonomiques que permet l'identification morphologique, les restes de vertébrés récupérés de dépôts de caverne concordent avec le biote moderne de la région, ce qui indiquerait un établissement de ce dernier tôt après le dernier maximum glaciaire et une stabilité relative des assemblages mammaliens durant l'Holocène. L'évaluation préliminaire de restes de plantes récupérés fait ressortir une source potentiellement sous-évaluée de données paléoécologiques pour les hautes altitudes. [Traduit par la Rédaction] Mots-clés: mammifères, chronologie, taphonomie, Holocène, Pléistocène, Introduction Quaternary palaeontological deposits preserved in caves are a significant data source for the reconstruction of past biotas (Harris 2005; Jass and George 2010; Harington 2011). Caves are especially significant [...]

Background/Objectives: Surgical deroofing is an essential part of ongoing management of Hidradenitis Suppurativa, including persistent lesions non‐responsive to medical therapy. The variables associated with delayed wound healing after surgical deroofing are contradictory within the literature due to the inclusion of heterogeneous surgical intervention methods. We aimed to assess the predictors of time to wound healing after surgical deroofing in HS. Methods: Patients who underwent in‐office surgical deroofing between 2020 and 2024 at a single tertiary HS referral centre were included in analysis. Demographic, disease and blood variables were collected as per standard of care. Statistical analysis was performed using univariate correlation, with multiple regression performed to explore the interactions between variables and identify variables predictive of time to wound healing. Results: A total of 270 individuals were included in the analysis. The median time to wound healing was 9.6 weeks with a range from 4 to 22 weeks. Kaplan–Meier curves demonstrated significant differences with the log rank test when comparing biologic use versus no use, normal versus abnormal CRP and normal versus abnormal haemoglobin. Cox regression analysis identified biologic use with a significant hazard ratio compared to no biologic therapy (HR = 2.512, p < 0.0001) along with baseline CRP (HR = 0.968, p < 0.0001) and baseline haemoglobin (HR = 1.052, p < 0.001). Conclusions: Time to wound healing after in‐office deroofing can be decreased with prior biologic therapy and markers of systemic inflammation in blood are also significantly associated with delays in healing. This correlates well with the existing literature promoting concurrent medical and surgical therapy to improve patient outcomes in HS. [ABSTRACT FROM AUTHOR]

Background/Objectives: Caucasian and Asian patients with hidradenitis suppurativa demonstrate significant differences with regard to age, gender and body mass index. Demographic characteristics are known to influence the efficacy and drug survival of hidradenitis suppurativa therapeutics including biologic therapies. What remains unknown is the impact of ethnicity upon the efficacy of therapeutics once demographic and disease characteristics have been taken into account. This is an important question given the expansion of biologic therapies for HS into the global patient community. Methods: We assessed 170 patients from a single HS specialist centre in Australia stratified by patient‐identified ethnicity including those identifying as either Caucasian or Asian. Results: Asian patients demonstrated lower BMI, higher rates of smoking and greater odds of Hurley stage 3 disease with tunnels than Caucasian patients in line with the reported literature. There was no significant difference between percentage of individuals achieving HiSCR50 or IHS4‐55 at Week 16. Significant differences were seen in median time to secondary loss of response, and Kaplan–Meier curve analysis showed a significant difference between curves when stratified by patient‐reported ethnicity. Cox regression analysis demonstrated after accounting for age, gender, BMI, smoking and Hurley stage, the significance of ethnicity in influencing time to secondary loss of response disappears. Conclusions: Caucasian or Asian ethnicity does not influence response to adalimumab treatment on patients with hidradenitis suppurativa. [ABSTRACT FROM AUTHOR]

Camelid remains are known from several Quaternary palaeontological localities in Alberta, yet most specimens are undescribed in the literature. Specimens reported here comprise a large sample of the known camelid record from the province and provide further insight into the record of Quaternary megafauna of western Canada. Remains from the Edmonton area include specimens pre- and post-dating the Last Glacial Maximum (LGM), whereas remains from the Vauxhall area are post-LGM. A metapodial fragment of a giant camel originally described as Titanotylopus from the Edmonton area is likely from earlier in the Pleistocene or late Pliocene. Camelid remains are not overly abundant in Alberta, but are widely distributed, having been recovered from several sites across the province. A new radiocarbon date of 11280 ± 40 [sup.14]C years BP on a radioulna of Camelops cf. C. hesternus represents only the fourth direct age assessment of a Quaternary camelid from Alberta. Radiocarbon data may suggest linkages to patterns of extirpation observed in camelid populations from northern Canada, followed by recolonization following deglaciation. Des restes de camelides sont connus de plusieurs localites paleontologiques quaternaires en Alberta, mais la plupart des specimens ne sont pas decrits dans des rapports publies. Les specimens signales dans le present article constituent un grand echantillon des camelides connus de cette province et accroissent les connaissances sur les megafaunes quaternaires de l'Ouest canadien. Des restes provenant de la region d'Edmonton comprennent des specimens anterieurs et posterieurs au dernier maximum glaciaire (DMG), alors que les restes de la region de Vauxhall sont posterieurs au DMG. Un fragment de metapode d'un chameau geant decrit initialement comme etant Titanotylopus de la region d'Edmonton serait vraisemblablement d'un age pleistocene plus ancien ou du Pliocene tardif. Les restes de camelides ne sont pas tres abondants en Alberta, mais sont repartis sur une grande etendue, ces restes ayant ete recuperes de plusieurs localites un peu partout dans la province. Un nouvel age au radiocarbone de 11280 ± 40 annees [sup.14]C BP obtenu d'un radiocubitus de Camelops cf. C. hesternus ne represente que la quatrieme evaluation directe de l'age d'un camelide du Quaternaire d'Alberta. Les donnees de radiocarbone pourraient indiquer des liens avec des motifs de disparition locale observes dans des populations de camelides du nord du Canada, suivie d'une recolonisation apres la deglaciation. [Traduit par la Redaction], Introduction Quaternary vertebrate remains recovered from gravel pit localities are the major source of information concerning Pleistocene megafauna in Alberta (e.g., Churcher 1968; Wilson and Churcher 1978; Churcher and Wilson [...]

The chemical compositions of toolstones composed of clastic and chemical sedimentary rock are often not distinct among procurement locations. However, sedimentary toolstone sources may show variations in the structural characteristics of the included carbonaceous material (CM) related to differences in their postdepositional histories, providing a potential proxy by which procurement locations, rather than individual rock units, can be assessed as raw material sources for archaeological lithics. Here, we apply a well‐established method for investigating the nature of CM in sedimentary rocks, Raman spectroscopy of carbonaceous material (RSCM), to an archaeological case study. We test if the technique can be used to differentiate among toolstones from two procurement areas along the eastern slopes of the Canadian Rocky Mountains potentially used by pre‐European contact Indigenous inhabitants of the Hummingbird Creek Site (FaPx‐1). Artifacts found during excavations at Hummingbird Creek visually appear to match toolstone‐grade rocks in the site's vicinity. We analyzed source material from two localities: (1) the local toolstone around FaPx‐1 and (2) a toolstone procurement area ~45 km away associated with many precontact workshop sites. To test if the artifacts have compositions consistent with the local toolstones, we analyzed artifacts and potential source materials with RSCM as well as their major, minor, and trace element composition using X‐ray fluorescence (XRF). Our work is guided by the elimination of source locations using indirect geochemical proxies in accordance with the exclusionary Provenance Hypothesis. Both the structural and the chemical characteristics of the artifacts are similar to those of geologic samples from the nonlocal source location and are not consistent with samples collected locally, permitting the exclusion of local materials and suggesting that the inhabitants of FaPx‐1 used a variety of toolstones to manufacture the artifacts from materials that do not appear to be readily available near the site. [ABSTRACT FROM AUTHOR]