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2. Round robin of external samples for residual stress analyses by X-ray diffraction

Author

Lefebvre, Fabien, Wasniewski, Eric, Bergey, Thierry, Roth, A., François, Manuel, Allain, Patrick, Le-Bec, P., Fisher, C., Berveiller, Sophie, Besnauld, Laurence, Mermillod-Blondin, L., Cheynet, Yann, Frappier, Renaud, Geandier, Guillaume, Moya, Marie-José, Savrot, F., CEntre Technique des Industries Mécaniques (CETIM), CEntre Technique des Industries Mécaniques - Cetim (FRANCE), ArianeGroup, Laboratoire des Systèmes Mécaniques et d'Ingénierie Simultanée (LASMIS), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Matériaux et Mécanique des Composants (EDF R&D MMC), EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux (LEM3), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Technique des Industries Mécaniques (CETIM), Etablissement de Senlis, Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and VU VAN, Jean-Baptiste

Subjects
[SPI]Engineering Sciences [physics], [SPI] Engineering Sciences [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

3. Material removal correction in residual stress analyses by X-ray diffraction: a GFAC project

Author

Lefebvre, Fabien, Wasniewski, Eric, Bergey, Thierry, Francois, Manuel, Billet, Mathieu, Mareau, Charles, Bouscaud, Denis, Besnault-Mascard, Laurence, LETORT, Elodie, Cheynet, Yann, Frappier, Renaud, Geandier, Guillaume, Le Roux, Jean-Marie, Allain, Patrick, CEntre Technique des Industries Mécaniques (CETIM), CEntre Technique des Industries Mécaniques - Cetim (FRANCE), ArianeGroup, Laboratoire des Systèmes Mécaniques et d'Ingénierie Simultanée (LASMIS), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Arts et Métiers ParisTech d'Angers - Procédés Matériaux Durabilité (LAMPA - PMD), Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux (LEM3), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies, Greffes d'Epitheliums et Regulation de l'Activation Lymphocytaire, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Structures et Marché Agricoles, Ressources et Territoires (SMART-LERECO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Technique des Industries Mécaniques (CETIM), Etablissement de Senlis, HESAM Université (HESAM)-HESAM Université (HESAM), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Arts et Métiers Sciences et Technologies, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI]Engineering Sciences [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

7. Characterization of the Absorption of Theophylline From Immediate- and Controlled-Release Dosage Forms With a Numerical Approach Using the In Vitro Dissolution-Permeation Process Using Caco-2 Cells.

Author

Noureddine, Nahla, Zerrouk, Naima, Nicolis, Ioannis, Allain, Patrick, Sfar, Souad, and Chaumeil, Jean-Claude

Subjects
THEOPHYLLINE, CELL permeability, CONTROLLED release drugs, ALKALOIDS, ANTIASTHMATIC agents, BRONCHODILATOR agents, CONTROLLED release preparations, CELL membranes, DOSAGE forms of drugs
Abstract

After oral administration, drug absorption rate is recognized to be dependent on two major factors: dissolution and intestinal cells permeability. Caco-2 monolayer cells have been largely used as a permeation study model. In this study, a numerical approach funded on an exponential first-order time relationship was tested to compare immediate- and controlled-release tablets of theophylline using a dissolution-permeation system. The dissolution performance using USP II paddle apparatus was coupled to the permeability studies investigated in Caco-2 cell monolayers. The dissolved samples were taken at different times; their pH and osmolarity were adjusted to render them suitable to Caco-2 permeability studies (osmolarity = 300 mosm, pH = 7.4). The experimental data show that the dissolution fits the exponential first-order relationship rate. The permeability values were in a range of 4.45 10 - 6 –5.28 10 - 6 cm/s, and percentages of absorbed drug dose were dependent on the fraction initially present in the donor compartment, indicating that absorption of theophylline was dissolution rate limited. Plotting experimental absorbed fractions (F a ) against experimental dissolved fractions (F d ) show that permeation is the rate-limiting step in drug absorption process in the extended release form of theophylline. Our results demonstrate a general agreement between observed F a /F d relationships and theoretical F a /F d relationships obtained with our approach funded on dissolution and permeation behavior. We concluded that the couple dissolution-caco-2 system could be a useful tool to characterize intestinal permeation for a new formulation of a drug compared with the conventional one. [ABSTRACT FROM AUTHOR]

Published
2005
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