1. Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases.
- Author
-
Kong YR, Tay KC, Su YX, Wong CK, Tan WN, and Khaw KY
- Subjects
- Alkaloids chemistry, Alkaloids therapeutic use, Alzheimer Disease pathology, Amyloid beta-Peptides antagonists & inhibitors, Amyloid beta-Peptides chemistry, Biological Products chemistry, Biological Products therapeutic use, Humans, Neurodegenerative Diseases metabolism, Neuroprotective Agents chemistry, Neuroprotective Agents therapeutic use, Oxidative Stress drug effects, Alkaloids antagonists & inhibitors, Alzheimer Disease drug therapy, Amyloid beta-Peptides therapeutic use, Neurodegenerative Diseases drug therapy
- Abstract
Alkaloids are a class of secondary metabolites that can be derived from plants, fungi and marine sponges. They are widely known as a continuous source of medicine for the management of chronic disease including cancer, diabetes and neurodegenerative diseases. For example, galanthamine and huperzine A are alkaloid derivatives currently being used for the symptomatic management of neurodegenerative disease. The etiology of neurodegenerative diseases is polygenic and multifactorial including but not limited to inflammation, oxidative stress and protein aggregation. Therefore, natural-product-based alkaloids with polypharmacology modulation properties are potentially useful for further drug development or, to a lesser extent, as nutraceuticals to manage neurodegeneration. This review aims to discuss and summarise recent developments in relation to naturally derived alkaloids for neurodegenerative diseases.
- Published
- 2021
- Full Text
- View/download PDF