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Background and aims It is not known if new onset diabetes during Coronavirus-19 disease (COVID-19; NOD COVID) is phenotypically or biochemically different than new onset diabetes before COVID-19 (NOD). Methods All adults diagnosed with new onset diabetes from during the time of COVID-19 were compared with new onset diabetes prior to COVID-19, from two tertiary care hospitals in Chennai and Delhi. RTPCR test for SARS-CoV-2 virus was done as appropriate, and COVID-19 antibody test was done in all other NOD COVID patients. Result A total of 555 patients with new onset diabetes were included in the study (282 NOD and 273 NOD COVID patients). Patients with NOD COVID had higher fasting and post prandial blood glucose and glycated hemoglobin vs. NOD patients. Both the groups had high average body mass index; ∼28 kg/m2. Interestingly, fasting C-peptide levels were significantly higher in the NOD COVID group vs. NOD group. There was no difference in C-peptide or glycemic parameters between the COVID-19 antibody positive and negative NOD COVID cases. Conclusion Individuals who were diagnosed with diabetes during COVID-19 epidemic (NOD COVID) do not significantly differ from those diagnosed before COVID-19 in symptomatology, phenotype, and C-peptide levels but they had more severe glycemia., Highlights • We studied 282 patients with new-onset diabetes before COVID-19 (NOD), and 273 new onset patients with diabetes during COVID-19 (NOD COVID). • Patients with NOD COVID had higher fasting blood glucose, post prandial blood glucose and glycated hemoglobin as compared to NOD patients. • There was no difference in C-peptide or glycemic parameters between the COVID-19 antibody positive and negative NOD COVID cases.

Aim: To compare the outcome variables of these 2 commonly used anti-metabolites 5-Fluorouracil and Mitomycin-C in trabeculectomy surgeries in primary glaucoma. Material & methods: The present study was conducted on 50 eyes of 39 patients of primary glaucoma who underwent trabeculectomy over a period from January 2019 to August 2020 at Darbhanga Medical College & Hospital, Laheriasarai, Darbhanga.The patients were randomly categorized into 2 groups of 25 each. One group received 5-Fluorouracil in the dose of 50 mg/ml for duration of 4 to 5 minutes intraoperatively. The other group received intraoperative Mitomycin-C in the dose of 0.4 mg/ml applied over duration of 2 to 3 minutes. Result:Maximum complications were seen during early postoperative period in which maximum number were seen with POAG (9 cases) followed by PACG (5 cases). Late postoperative complications were seen in POAG and PACG (2 in each). Conclusion:Long-term complications may only become apparent many years later. Since our study had average period follow up of about 42 weeks, we are not able to comment on the long-term complications following the use of these drugs. In this study both 5-Fluorouracil and Mitomycin-C were found to be equally safe.

Aim:To evaluate the efcacy of topical Voriconazole in the treatment of fungal corneal ulcer. Materials and methods: It was a single centre prospective tertiary care hospital based study conducted in the Upgraded Department of Ophthalmology at DARBHANGA MEDICAL COLLEGE AND HOSPITAL, Laheriasarai. It included 25 corneal ulcer patients of all demographic and socioeconomic status attending outdoor and/or indoor of Department of Ophthalmology, from April 2019 to April 2020, for a period of one year. Result: Majority of the patients were females.The decrease in ulcer size and improvement in visual acuity post treatment with topical Voriconazole was found to be statistically signicant. Conclusion: Topical therapy with 1% Voriconazole (w/v) served to be an economical mode of treating fungal corneal ulcer. It helped in the early and complete resolution of the ulcer with no adverse effects.

Aim: To evaluate the amount and type of surgically induced astigmatism in superior and temporal scleral incision in Manual Small Incision Cataract Surgery (MSICS). Material and Methods: A prospective randomized comparative study was carried out in Upgraded Department of Ophthalmology, DMCH, Laheriasarai, Bihar. Total 100 cases of senile or pre-senile cataract included in this study from July 2019 to December 2019. All the patients underwent MSICS under peribulbar anaesthesia. The patients with very hard cataract were excluded so as to keep the incision size uniformity (6- 6.5mm). 50 cases received superior scleral incision and 50 cases received temporal scleral incision. Post operative astigmatism was studied in both groups using Bausch & Lomb Keratometer on 1st day, 7th day, 6th week and 3rd month. Results: After 3 months of surgery, out of 50 patients in superior scleral incision group 74% patients had ATR astigmatism and 16% patients had WTR astigmatism whereas in temporal scleral incision group 56 % of the patients had WTR astigmatism and 36 % had ATR astigmatism. The mean surgically induced astigmatism (SIA) in temporal incision group was signicantly less than the superior incision group after 3 months postoperatively (t=2.33, p

Background Dipeptidyl peptidase 4 (DPP4) inhibitors have increasingly been linked to bullous pemphigoid, but there is paucity of data from India where about 1.85 million patients have been estimated to use these drugs. Methods In 30,000 patients with T2DM seen by us in two tertiary care centres since 2015, we detected 13 cases of bullous pemphigoid linked to DPP4 inhibitors. We used WHO-UMC (World Health Organisation-Uppsala Monitoring Centre) causality assessment system for assessment. Results Lesions of bullous pemphigoid appeared at varied intervals (within 1 weeks–2 years) after start of DPP4 inhibitors. Implicated drugs were Linagliptin (n, 8), Vildagliptin (n, 4) and Sitagliptin (n, 1). Mostly, lesions were seen after 60 years age, and over trunk and extremities. Skin biopsy was compatible with bullous pemphigoid in two patients. Lesions regressed within a month of stopping DPP4 inhibitors in 9 patients while delayed regression up to 6 months in 4 patients. Overall, skin lesions remitted in all patients and did not recur. Conclusion Any new bullous lesion appearing while patient is on DPP4 inhibitors should be considered as bullous pemphigoid and should necessitate prompt withdrawal of the drug.

Background and aims Mucormycosis is an invasive fungal infection and carries a significant morbidity and mortality. A number of cases of mucormycosis have been reported in association with COVID-19. In this study, a consortium of clinicians from various parts of India studied clinical profile of COVID-19 associated mucormycosis (CAM) and this analysis is presented here. Methods Investigators from multiple sites in India were involved in this study. Clinical details included the treatment and severity of COVID-19, associated morbidities, as well as the diagnosis, treatment and prognosis of mucormycosis. These data were collected using google spreadsheet at one centre. Descriptive analysis was done. Results There were 115 patients with CAM. Importantly, all patients had received corticosteroids. Diabetes was present in 85.2% of patients and 13.9% of patients had newly detected diabetes. The most common site of involvement was rhino-orbital. Mortality occurred in 25 (21.7%) patients. On logistic regression analysis, CT scan-based score for severity of lung involvement was associated with mortality. Conclusion Universal administration of corticosteroids in our patients is notable. A large majority of patients had diabetes, while mortality was seen in ∼1/5th of patients, lower as compared to recently published data.