90 results on '"Alka Agarwal"'
Search Results
2. Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections
- Author
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Alka Agarwal, Preeti Singh, Anand Maurya, Upendra Kumar Patel, Alka Singh, and Gopal Nath
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Chemistry ,QD1-999 - Published
- 2022
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Catalog
3. Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects
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Rajiv Dahiya, Sunita Dahiya, Neeraj Kumar Fuloria, Suresh Kumar, Rita Mourya, Suresh V. Chennupati, Satish Jankie, Hemendra Gautam, Sunil Singh, Sanjay Kumar Karan, Sandeep Maharaj, Shivkanya Fuloria, Jyoti Shrivastava, Alka Agarwal, Shamjeet Singh, Awadh Kishor, Gunjan Jadon, and Ajay Sharma more...
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azole-based peptide ,marine sponge ,peptide synthesis ,cytotoxicity ,cyanobacteria ,thiazole ,Biology (General) ,QH301-705.5 - Abstract
Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide–peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents. more...
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- 2020
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4. Lack of stimulation of cholesteryl ester transfer protein by cholesterol in the presence of a high-fat diet
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Sukhinder Kaur Cheema, Alka Agarwal-Mawal, Cathy M. Murray, and Stephanie Tucker
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transgenic mice ,dietary fat and cholesterol ,liver X receptor α ,peroxisome proliferator-activated receptor α ,Biochemistry ,QD415-436 - Abstract
Cholesteryl ester transfer protein (CETP) is a key protein involved in the reverse cholesterol transport pathway. The regulation of CETP by dietary fats is not clearly understood. Transgenic mice expressing human CETP under the control of its natural flanking region were fed low- or high-fat diets enriched in monounsaturated fatty acids (MUFAs) or saturated fatty acids in the presence or absence of cholesterol. Addition of cholesterol to the low-fat MUFA diet increased CETP activity and mRNA expression, whereas addition of cholesterol to the high-fat MUFA diet led to a decrease in CETP activity and mRNA expression. In SW 872 cells, oleic acid and cholesterol stimulated CETP gene expression when given alone. However, addition of fatty acids along with cholesterol interfered with the stimulatory effect of cholesterol on CETP gene regulation. Cholesterol-mediated stimulation of CETP involves the transcription factor liver X receptor α (LXRα). High-fat MUFA diets inhibited the expression of LXRα, and addition of cholesterol to the high-fat MUFA diet did not rescue LXRα expression.Therefore, we present evidence for the first time that inhibition of LXRα expression by a high-fat MUFA diet leads to inhibition of CETP stimulation by cholesterol. more...
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- 2005
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5. She has got a gig: affordances of on-demand work apps for marginalised women enduring time scarcity.
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Alka Agarwal, Ashish Kumar Jha 0001, and Jyoti Jagasia
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- 2024
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6. DIGITAL PAYMENT PLATFORMS AND SUBSISTENCE ENTREPRENEURS: CHAMPIONING BEYOND THE PANDEMIC.
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Alka Agarwal, Ashish Kumar Jha 0001, and Jyoti Jagasia
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- 2024
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7. 1-Prop-2-ynyl-1H-benzimidazol-2-amine
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Alka Agarwal, Manavendra K. Singh, and Satish K. Awasthi
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Crystallography ,QD901-999 - Abstract
In the title compound, C10H9N3, the benzimidazol-2-amine and CH2—C[triple-bond]CH units are not coplanar, with a dihedral angle of 60.36° between their mean planes. The crystal structure is stabilized by intermolecular N—H...N hydrogen bonding and π–π interactions [centroid–centroid distances 3.677 (1) and 3.580 (1) Å], assembling the molecules into a supramolecular structure with a three-dimensional network. more...
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- 2011
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8. 2-(4-Chlorophenyl)chromen-4-one
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Shailja Singh, Manavendra K. Singh, Alka Agarwal, and Satish K. Awasthi
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Crystallography ,QD901-999 - Abstract
The title compound, C15H9ClO2, is a synthetic flavonoid obtained by the cyclization of 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one. The 4-chlorophenyl ring is twisted at an angle of 11.54° with respect to the chromen-4-one skeleton. In the crystal, pairs of molecules are interconnected by weak Cl...Cl interactions [3.3089 (10) Å] forming dimmers which are further peripherally connected through intermolecular C—H...O hydrogen bonds. more...
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- 2011
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9. N-(Prop-2-yn-1-yl)-1,3-benzothiazol-2-amine
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Satish K. Awasthi, Suryabhan Singh, S. Bhattacharya, Manavendra Kumar Singh, and Alka Agarwal
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Crystallography ,QD901-999 - Abstract
In the title compound, C10H8N2S, the 2-aminobenzothiazole and propyne groups are not coplanar [dihedral angle = 71.51 (1)°]. The crystal structure is stabilized by strong intermolecular N—H...N hydrogen bonds and C—H...C, C—H...π and F-type aromatic–aromatic [centroid–centroid distance = 3.7826 (12) Å] interactions are also observed. more...
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- 2011
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10. (2E)-1-(4-Aminophenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one
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Shailja Singh, Manavendra K. Singh, Alka Agarwal, Firasat Hussain, and Satish K. Awasthi
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Crystallography ,QD901-999 - Abstract
The title compound, C15H11Cl2NO, is approximately planar (r.m.s. deviation = 0.062 Å) and contains a single C=C double bond in a trans (E) configuration. The crystal packing is stabilized by intermolecular N—H...N and N—H...O intermolecular hydrogen bonding. more...
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- 2011
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11. tert-Butyl N-{2-[bis(prop-2-yn-1-yl)amino]phenyl}carbamate
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Manavendra K. Singh, Alka Agarwal, Charu Mahawar, and Satish K. Awasthi
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Crystallography ,QD901-999 - Abstract
In the crystal of the title compound, C17H20N2O2, the molecules are linked by C—H...O interactions. Intramolecular C—H...O and N—H...N hydrogen bonds also occur.
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- 2011
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12. Benzyl N-(3-chloro-4-fluorophenyl)carbamate
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Manavendra K. Singh, Alka Agarwal, and Satish K. Awasthi
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Crystallography ,QD901-999 - Abstract
The title compound, C14H11ClFNO2, the phenyl ring (A), the chlorofluorophenyl ring (B) and the central ketone O/C/O group (C) are not coplanar, with dihedral angles B/C = 31.6 (2), A/B = 21.3 (2) and A/C = 50.1 (2)°. The crystal packing is stabilized by N—H...O and C—H...O interactions. more...
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- 2011
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13. The Effect of Mindfulness-based Cognitive Therapy on Anxiety and Resilience of the School Going Early Adolescents with Anxiety
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Anoop Peter, Rani Srivastava, Alka Agarwal, and Anand Pratap Singh
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Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health - Abstract
Background: The increasing mental health problems of Indian adolescents are of great concern but child-health mental service is in a nascent stage. Anxiety is the most common psychological problem found in school-going children. The psychological intervention for this high-risk population at an early stage of adolescence can prevent mental health problems. Aim: The study aimed to assess the applicability and effectiveness of mindfulness-based cognitive therapy (MBCT) on resilience and anxiety of early school-going adolescents with anxiety. Method: This study used pre, post, and follow-up with a randomized control group design. Out of 200 samples screened by Preliminary Identification Performa and Clinical Interview Schedule (PI&CI), General Health Questionnaire-12 (GHQ-12), Spence Children’s Anxiety Scale (SCAS), and Brief Psychiatry Rating Scale (BPRS-C), 72 samples aged between 10 to 14 were included in the final study and grouped into two equal groups through a simple randomized method. Psychological intervention based on mindfulness (PIBM) group with N = 36 received 12 sessions of mindfulness-based intervention (MBCT-C) but only 33 completed up to follow-up. Only N = 32 in Treatment Waiting List (TWL) group completed three assessments who received parental counseling about anxiety. The outcome measures were Child and Adolescent Mindfulness Measure (CAMM), SCAS, Bharathiar University Resilience Scale (BURS). Result: The findings suggested that the PIBM group significantly improved in mindfulness and resilience, and anxiety symptoms were reduced. The effect size observed is strong and the post hoc t-test showed significant change in variables in every assessment duration. The TWL group did not have significant change. Thus MBCT-C is an applicable and effective intervention for a early school-going adolescent with anxiety. more...
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- 2022
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14. Evidence-Based Treatment, assisted by Mobile Technology to Deliver, and Evidence-Based Drugs in South Asian Countries
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Ankita Wal, Madhusmruti Khandai, Himangi Vig, Parul Srivastava, Alka Agarwal, Seema Wadhwani, and Pranay Wal
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General Medicine - Published
- 2022
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15. Use Cases of Smart Contracts in Decentralized Health Infrastructure
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Sabita Khatri, Alka Agarwal, Rajeev Kumar, and Raees Ahmad Khan
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- 2023
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16. Is structural hybridization invoking new dimensions for antimalarial drug discovery research?
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Bhawana Sharma, Alka Agarwal, and Satish Kumar Awasthi
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Pharmacology ,Organic Chemistry ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine ,Biochemistry - Abstract
This review article outlines the currently published most potent hybrid drugs against the Plasmodium species.
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- 2023
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17. Strategies to Combat Multidrug Resistance by Non-traditional Therapeutic Approaches
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Harsh Yadav, Anand Maurya, Alka Agarwal, Anurag Kumar Singh, Satish Dubey, Aditya Moktan Tamang, Reshu Agrawal, and Sushil Kumar Chaudhary
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- 2023
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18. Natural Thiazoline-Based Cyclodepsipeptides from Marine Cyanobacteria: Chemistry, Bioefficiency and Clinical Aspects
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Rajiv Dahiya, Neeraj Kumar Fuloria, Wellecia Mullings, Vishal Radhay, Yashoda Ramsubhag, Alka Agarwal, Vernon Davis, Satish Jankie, Sunita Dahiya, Zachary Langford, Zekiel Bedassie, Vijaya Sahadeo, and Shivkanya Fuloria more...
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Pharmacology ,chemistry.chemical_classification ,Biological Products ,Drug discovery ,Chemistry ,Biomolecule ,Thiazoline ,Organic Chemistry ,Computational biology ,Cyanobacteria ,Peptides, Cyclic ,Biochemistry ,Small molecule ,Cyclic peptide ,Chemical space ,chemistry.chemical_compound ,Biopharmaceutical ,Depsipeptides ,Drug Discovery ,Molecular targets ,Humans ,Molecular Medicine ,Prospective Studies - Abstract
Background: Peptides and peptide-based therapeutics are biomolecules that demarcate a significant chemical space to bridge small molecules with biological therapeutics, such as antibodies, recombinant proteins, and protein domains. Introduction: Cyclooligopeptides and depsipeptides, particularly cyanobacteria-derived thiazoline-based polypeptides (CTBCs), exhibit a wide array of pharmacological activities due to their unique structural features and interesting bioactions, which furnish them as promising leads for drug discovery. Methods: In the present study, we comprehensively review the natural sources, distinguishing chemistries, and pertinent bioprofiles of CTBCs. We analyze their structural peculiarities counting the mode of actions for biological portrayals which render CTBCs as indispensable sources for emergence of prospective peptide-based therapeutics. In this milieu, metal organic frameworks and their biomedical applications are also briefly discussed. To boot, the challenges, approaches, and clinical status of peptide-based therapeutics are conferred. Results: Based on these analyses, CTBCs can be appraised as ideal drug targets that have always remained a challenge for traditional small molecules, like those involved in protein- protein interactions or to be developed as potential cancer-targeting nanomaterials. Cyclization-induced reduced conformational freedom of these cyclooligopeptides contribute to improved metabolic stability and binding affinity to their molecular targets. Clinical success of several cyclic peptides provokes the large library-screening and synthesis of natural product-like cyclic peptides to address the unmet medical needs. Conclusion: CTBCs can be considered as the most promising lead compounds for drug discovery. Adopting the amalgamation of advanced biological and biopharmaceutical strategies might endure these cyclopeptides to be prospective biomolecules for futuristic therapeutic applications in the coming times. more...
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- 2021
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19. Microbiome and host crosstalk: A new paradigm to cancer therapy
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Ashutosh Singh, Yamini B. Tripathi, Deepanshu Verma, Ashun Chaudhary, Preeti Rathi, Neha Garg, Rohit Sharma, Alka Agarwal, and Namyashree Nayak
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0301 basic medicine ,Cancer Research ,medicine.medical_treatment ,Cancer therapy ,Antineoplastic Agents ,Biology ,Bioinformatics ,Immunomodulation ,03 medical and health sciences ,Human health ,0302 clinical medicine ,Immune system ,Neoplasms ,medicine ,Animals ,Humans ,Microbiome ,Host Microbial Interactions ,Human microbiome ,Immunotherapy ,Gastrointestinal Microbiome ,Crosstalk (biology) ,Prebiotics ,030104 developmental biology ,Close relationship ,030220 oncology & carcinogenesis - Abstract
The commensal microbiome of humans has co-evolved for thousands of years. The microbiome regulates human health and is also linked to several diseases, including cancer. The advances in next-generation sequencing have significantly contributed to our understanding of the microbiome and its association with cancer and cancer therapy. Recent studies have highlighted a close relationship of the microbiome to the pharmacological effect of chemotherapy and immunotherapy. The chemo-drugs usually interfere with the host immune system and reduces the microbiome diversity inside the body, which in turn leads to decreased efficacy of these drugs. The human microbiome, specifically the gut microbiome, increases the potency of chemo-drugs through metabolism, enzymatic degradation, ecological differences, and immunomodulation. Recent research exploits the involvement of microbiome to shape the efficacy and decrease the toxicity of these chemo-drugs. In this review, we have highlighted the recent development in understanding the relationship of the human microbiome with cancer and also emphasize on various roles of the microbiome in the modulation of cancer therapy. Additionally, we also summarize the ongoing research focussed on the improved efficacy of chemotherapy and immunotherapy using the host microbiome. more...
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- 2021
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20. Molecular docking and density functional theory studies of potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles antifilarial compounds
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Jitendra Kumar Yadav, Priyanka Yadav, Alka Agarwal, and Vinay Kumar Singh
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010405 organic chemistry ,Chemistry ,Hydrogen bond ,Stereochemistry ,010402 general chemistry ,Condensed Matter Physics ,Ligand (biochemistry) ,01 natural sciences ,0104 chemical sciences ,Molecular dynamics ,Docking (molecular) ,Molecular orbital ,Density functional theory ,Physical and Theoretical Chemistry ,HOMO/LUMO ,Discovery Studio - Abstract
The interaction of three potent antifilarial compounds (4C, 4F, and 3F) with filarial proteins thioredoxin, glutathione s-transferase and cyclophilin were investigated using molecular docking and density functional theory (DFT) studies. Molecular docking was performed using YASARA tool, Hex 8.0.0 Cuda tool and PatchDock server and docked complex were visualized by Discovery Studio 3.0. The predicted binding energy of antifilarial compounds 4C (−247.6, −243.8, −256.8 kcal mol−1), 4F (−242.6, −246.4, −232.4 kcal mol−1) and 3F (−272.4, −248.5, −277.7 kcal mol−1) with filarial protein 4FYU, 5D73, and 1A33, respectively. Docking results were strongly supported by molecular dynamics data and molecular mechanics-generalized born surface area (MM-GBSA) calculations. The optimized geometries of all three compounds were used for calculating the energies of the frontier molecular orbitals highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO). The lowest HOMO–LUMO energy gap in compound 3F suggested that it is the most bioactive molecule among all these three compounds, which is in accordance with the docking results of these compounds. The interaction energies between ligand and protein are mainly due to hydrogen bonds, hydrophobic interactions, and van der Waals interactions which give the stability to the complex. The structural information and docking studies of different filarial proteins with antifilarials obtained from this study could aid in screening and designing new antifilarial or selective inhibitors for chemotherapy against filariasis. more...
- Published
- 2021
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21. A Novel Augmented Fractional-Order Fuzzy Controller for Enhanced Robustness in Nonlinear and Uncertain Systems with Optimal Actuator Exertion
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Vishal Goyal, Alka Agarwal, and Puneet Mishra
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Nonlinear system ,Multidisciplinary ,Control theory ,Computer science ,Robustness (computer science) ,Control system ,010102 general mathematics ,0101 mathematics ,Actuator ,01 natural sciences ,Fuzzy logic ,Parametric statistics ,Fractional calculus - Abstract
An appropriate balance between the controller’s performance and its robustness is a complex design challenge. In order to enhance the control system performance, vigorous and rapid variations in controller output are often employed; however, this poses a critical challenge for practical implementations of the control schemes, as it may affect the actuator badly and may reduce its lifetime. To handle this issue, the current work presents an innovative control structure that aims to strike an apt balance between the control output variability while maintaining the desired control performance. The proposed control scheme exploits the abilities of fuzzy logic to cope with uncertainties in the system and along with the use of fractional calculus to enhance the control performance. Further, to evaluate the performance of the proposed improved fractional-order fuzzy controller (IFOFC), extensive simulation studies have been carried out on a multi-input–multi-output nonlinear system for a wide variety of test scenarios. An exhaustive comparative study with an inline state-of-art controller, i.e., fractional-order fuzzy PID (FOFPID) controller has also been carried out on two interesting performance measures. These performance measures include integral of time-weighted absolute error (ITAE) and another measure which corresponds to undesirable variations in the controller output, i.e., integral of the absolute change of torque (IACT). Based on the detailed simulation studies, it was found that the proposed control structure provides a fair balance between controller output aggression and control performance and also completely outperformed the FOFPID controller, even under large parametric variations. more...
- Published
- 2021
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22. A Review on Pharmacological Aspects of Pyrimidine Derivatives
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Udichi Kataria, Sakshi Soni, Alka Agarwal, Chandra Prakash Joshi, and Vishal Verma
- Abstract
Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogens at positions 1 and 3 in the ring. Pyrimidines are typically synthesized by the “Principal Synthesis” involving cyclization of beta-dicarbonyl compounds with N-C-N compounds. Reaction of the former with amidines to give 2-substituted pyrimidines, with urea to give 2-pyrimidiones, and guanidines to give 2-aminopyrimidines are typical. Pyrimidines can be prepared via the biginelli reaction. Many other methods rely on condensation of carbonyls with diamines for instance the synthesis of 2-Thio-6-methyluracil from thiouria and ethyl acetoacetate or the synthesis of 4-methylpyrimidine with 4, 4-dimethoxy-2-butanone and formamide. Pyrimidine derivatives show antimicrobial activity, anticancer activity, anti-inflammatory activity, antidiabetic, and analgesic activity.1. Keywords: Pyrimidine derivatives, Synthesis, derivatives and pharmacological activities. more...
- Published
- 2020
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23. Efficient N-formylation of primary aromatic amines using novel solid acid magnetic nanocatalyst
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Jitendra Kumar Yadav, Satish K. Awasthi, Alka Agarwal, and Priyanka Yadav
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chemistry.chemical_classification ,chemistry ,Cost effectiveness ,General Chemical Engineering ,Yield (chemistry) ,Magnet ,Magnetic nanoparticles ,Substrate (chemistry) ,General Chemistry ,Sulfonic acid ,Combinatorial chemistry ,Catalysis ,Formylation - Abstract
Sulfonic acid functionalized over biguanidine fabricated silica-coated heterogeneous magnetic nanoparticles (NP@SO3H) have been synthesized, well characterized and explored for the first time, as an efficient and recyclable catalyst for N-formylation of primary amines under mild reaction conditions. Exploiting the magnetic nature of Fe3O4, the prepared catalyst was readily recovered from the reaction mixture via an external magnet. The catalyst can be reused for up to six cycles without any substantial loss of catalytic activity. The cost effectiveness, simple methodology, wide substrate tolerance, excellent yield and easy work-up are the additional advantages of present catalytic system. more...
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- 2020
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24. Challenges and Recent Advances of Novel Chemical Inhibitors in Medulloblastoma Therapy
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Anand, Maurya, Upendra Kumar, Patel, Jitendra Kumar, Yadav, Virender Pratap, Singh, and Alka, Agarwal
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Humans ,Hedgehog Proteins ,Cerebellar Neoplasms ,Medulloblastoma - Abstract
Medulloblastoma is a common term used for the juvenile malignant brain tumor, and its treatment is exciting due to different genetic origins, improper transportation of drug across the blood-brain barrier, and chemo-resistance with various side effects. Currently, medulloblastoma divided into four significant subsections (Wnt, Shh, Group 3, and Group 4) is based on their hereditary modulation and histopathological advancement. In this chapter, we tried to combine several novel chemical therapeutic agents active toward medulloblastoma therapy. All these compounds have potent activity to inhibit the medulloblastoma. more...
- Published
- 2022
25. Challenges and Recent Advances of Novel Chemical Inhibitors in Medulloblastoma Therapy
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Anand Maurya, Upendra Kumar Patel, Jitendra Kumar Yadav, Virender Pratap Singh, and Alka Agarwal
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- 2022
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26. Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections
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Alka Agarwal, Preeti Singh, Anand Maurya, Upendra Kumar Patel, Alka Singh, and Gopal Nath
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Chemistry ,General Chemical Engineering ,General Chemistry ,QD1-999 ,Article - Abstract
A newer ciprofloxacin series containing 1,2,3-triazole conjugates of ciprofloxacin was designed, synthesized, and well characterized using modern analytical techniques by reacting diversified anilines with ciprofloxacin obtained from ciprofloxacin hydrochloride. The newer conjugates were evaluated for their antimicrobial activity against various strains, viz. Staphylococcus aureus (ATCC25923), Enterococcus faecalis (clinical isolate), Staphylococcus epidermidis (ATCC3594), Escherichia coli (ATCC25922), Pseudomonas aeruginosa (ATCC27853), Salmonella typhi (clinical isolate), Salmonella typhimurium (clinical isolate), Acinetobacter baumannii (ATCC19606), Aeromonas hydrophila (ATCC7966), Plesiomonas shigelloides (ATCC14029), and Sphingo biumpaucimobilis (MTCC6362) in vitro. Interestingly, some of the conjugates showed superior antimicrobial activity as compared to the control drug ciprofloxacin. The three compounds 4i, 4j, and 4n showed strong activity with minimum inhibitory concentration (MIC) 0.78 μM, while the compound 4g showed MIC 1.56 μM against S. typhi (clinical). The compound 4a showed good efficacy against S. aureus (ATCC25923) and S. typhi (clinical) with MIC 3.12 μM, while the compound 4b exhibited efficacy with MIC 3.12 μM against S. aureus (ATCC25923) and the control drug ciprofloxacin showed MIC 6.25 μM. Among all of the synthesized compounds, 4e, 4f, 4g, 4h, 4p, 4q, 4t, and 4u displayed less than 20% hemolysis, while the rest of the compounds showed hemolysis in the range of 21–48%. Moreover, the structure of compound 4b was also established by single-crystal X-ray diffraction studies. more...
- Published
- 2021
27. Insights into the interaction of potent antimicrobial chalcone triazole analogs with human serum albumin: spectroscopy and molecular docking approaches
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Jitendra Kumar Yadav, Priyanka Yadav, Satish K. Awasthi, and Alka Agarwal
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Chalcone ,Circular dichroism ,Quenching (fluorescence) ,Stereochemistry ,Hydrogen bond ,General Chemical Engineering ,Triazole ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Human serum albumin ,01 natural sciences ,0104 chemical sciences ,Hydrophobic effect ,chemistry.chemical_compound ,chemistry ,medicine ,0210 nano-technology ,Protein secondary structure ,medicine.drug - Abstract
Mechanistic insights into the interaction of five previously chemically synthesized triazole-linked chalcone analogs (CTs) with human serum albumin (HSA) were sought using various spectroscopic techniques (UV-visible absorption, fluorescence, and circular dichroism) and molecular docking. The fluorescence quenching experiments performed at three different temperatures (288, 298 and 308 K) revealed the static mode of quenching and the binding constants (Kb ∼ 106–9) obtained indicated the strong affinity of these analogs for HSA. Furthermore, significant changes in the secondary structure of HSA in the presence of these analogs were also confirmed by far UV-CD spectroscopy. The thermodynamic properties such as the enthalpy change (ΔH°), Gibbs free energy change (ΔG°) and entropy change (ΔS°) revealed that the binding process was spontaneous and exothermic. Theoretical studies, viz., DFT and molecular docking corroborated the experimental results as these five analogs could bind with HSA through hydrogen bonding and hydrophobic interactions. The present study provides useful information regarding the interaction mechanism of these analogs with HSA, which can provide a new avenue to design more potent chalcone triazole analogs for use in the biomedical field. more...
- Published
- 2019
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28. Efficient
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Jitendra Kumar, Yadav, Priyanka, Yadav, Satish K, Awasthi, and Alka, Agarwal
- Abstract
Sulfonic acid functionalized over biguanidine fabricated silica-coated heterogeneous magnetic nanoparticles (NP@SO
- Published
- 2020
29. Role of Curriculum in Management Education : A Demographic Study
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Alka Agarwal and S. Singh
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Medical education ,Demographic study ,Psychology ,Curriculum - Published
- 2018
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30. Technical Education Graduates : A Critical Study of Skills-Set Requirements of Indian Industries across Different Verticals
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S. Singh, Alka Agarwal, and Ravindra Kumar
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Engineering management ,Vocational education ,General Engineering ,Business ,Set (psychology) - Published
- 2018
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31. Inherent Flexibility vis-à-vis Structural Rigidity in Chemically Stable Antimalarial Dispiro N -Sulfonylpiperidine Tetraoxanes
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Jitendra Kumar Yadav, Alka Agarwal, Satish Kumar Awasthi, Kumkum Sharma, and Chiranjeev Sharma
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Flexibility (anatomy) ,010405 organic chemistry ,Hydrogen bond ,Chemistry ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Crystallography ,medicine.anatomical_structure ,medicine ,Pseudorotation ,Tetraoxanes ,Structural rigidity - Published
- 2018
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32. Synthesis, characterization, Hirshfeld surfaces and DFT computation of novel benzyl N -(1,3-benzothiazol-2-yl)- N -benzylcarbamate
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Alka Agarwal, Biswajit Maiti, and Rama Kant
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Absorption spectroscopy ,010405 organic chemistry ,Hydrogen bond ,Chemistry ,Chemical shift ,Organic Chemistry ,Intermolecular force ,Crystal structure ,Carbon-13 NMR ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,Inorganic Chemistry ,Crystallography ,Computational chemistry ,Density functional theory ,Spectroscopy ,Monoclinic crystal system - Abstract
The compound benzyl N-(1,3-benzothiazol-2-yl)-N-benzylcarbamate was synthesized from 2-aminobenzothiazole and characterized by FT-IR, NMR, UV–Vis, X-ray diffraction and quantum chemical calculations. The compound crystallizes in the monoclinic, space group P21, with unit cell parameters of a = 11.5904(18) A, b = 5.5213(7) A, c = 15.251(2) A, β = 112.217(16)°, V = 903.5(2) A3 and Z = 2. The weak intermolecular C H⋯O and C H⋯π hydrogen bonds stabilized the crystal structure. Hydrogen bonding patterns were investigated in proposed compound on the behalf of X-ray analysis and its assignment with recognized terminological notations. The optimized geometrical parameters, harmonic vibrational frequencies, electrostatic potential surface and Milliken charges were calculated using hybrid Density Functional Theory (DFT/B3LYP) method with 6-31 + G(d,p) basis set. 1H and 13C NMR chemical shifts were also calculated at the same level of theory. The TD-DFT calculations have been performed to explore the electronic absorption spectra. Our computed data are in good agreement with the experimental values. more...
- Published
- 2017
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33. An efficient and economical synthesis of 5-substituted 1H-tetrazoles via Pb(II) salt catalyzed [3+2] cycloaddition of nitriles and sodium azide
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Rama Kant, Vishal Singh, and Alka Agarwal
- Subjects
chemistry.chemical_classification ,010405 organic chemistry ,Chemistry ,Cost effectiveness ,General Chemical Engineering ,Lead chloride ,Salt (chemistry) ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Cycloaddition ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Yield (chemistry) ,5 substituted 1h tetrazoles ,Sodium azide ,Organic chemistry - Abstract
A simple, mild and efficient method is developed for the synthesis of 5-substituted 1H-tetrazoles. Out of three used Pb(II) catalysts, lead chloride (PbCl2) has been found to be an efficient catalyst for [3+2] cycloaddition of NaN3 with aromatic and aliphatic nitriles to afford 5-substituted 1H-tetrazoles. The catalyst is reusable up to four cycles with consistent activity. The cost effectiveness and easy availability of the catalyst, simple methodology, excellent yield and easy work-up are the additional advantages. more...
- Published
- 2016
- Full Text
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34. Thermal and Crystallographic Studies of tert-Butyl 2-amino-1H-1,3-benzodiazole-1-carboxylate
- Author
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Alka Agarwal, Rama Kant, and Vishal Singh
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010405 organic chemistry ,Chemistry ,Hydrogen bond ,Intermolecular force ,General Physics and Astronomy ,Crystal structure ,010403 inorganic & nuclear chemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Crystallography ,Molecule ,Orthorhombic crystal system ,Carboxylate ,Thermal analysis ,Single crystal - Abstract
tert-Butyl 2-amino-1H-1,3-benzodiazole-1-carboxylate was synthesized by the reaction of di-tert-butyl dicarbonate with 2-aminobenzimidazole in good yield. The compound was characterized by FT-NMR, FT-IR and single crystal X-ray diffraction. The compound crystallized in orthorhombic lattice with Pbca space group and having unit cell parameters of a = 15.5303(6) A, b = 9.3643(4) A, c = 17.2112(7) A, V = 2503.03(18) A3, Dx = 1.238 mg m−3 and Z = 8. The crystal structure of compound was stabilized by N–H···N and C–H···O intermolecular interactions. The molecules are arranged into zig-zag manner in a dimeric form by N2–H1A···N1 and C12–H12C···O intermolecular hydrogen bonding which exhibited center of symmetric $$ {\text{R}}^{2}_{2} (8) $$ and chain $$ \text{C}^{1}_{1} (8) $$ patterns respectively. The thermal analysis of crystal was determined by DSC and TGA. more...
- Published
- 2016
- Full Text
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35. Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects
- Author
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Awadh Kishor, Rita Mourya, Jyoti Shrivastava, Ajay Sharma, Gunjan Jadon, Alka Agarwal, Hemendra Gautam, Sunil K. Singh, Satish Jankie, Shivkanya Fuloria, Neeraj Kumar Fuloria, Sunita Dahiya, Rajiv Dahiya, Sanjay Kumar Karan, Suresh Kumar, Sandeep Maharaj, Suresh V. Chennupati, and Shamjeet Singh more...
- Subjects
Aquatic Organisms ,Allosteric regulation ,azole-based peptide ,Pharmaceutical Science ,Peptide ,Review ,Computational biology ,010402 general chemistry ,cyanobacteria ,01 natural sciences ,chemistry.chemical_compound ,peptide synthesis ,Drug Discovery ,Peptide synthesis ,Animals ,Humans ,Thiazole ,lcsh:QH301-705.5 ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,chemistry.chemical_classification ,Biological Products ,Oligopeptide ,Molecular Structure ,010405 organic chemistry ,Drug discovery ,0104 chemical sciences ,Thiazoles ,lcsh:Biology (General) ,chemistry ,bioactivity ,cytotoxicity ,Peptides ,thiazole ,marine sponge - Abstract
Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide–peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents. more...
- Published
- 2020
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36. Synthetic and Crystallographic Studies of (9-Ethyl-9H-carbazol-3-yl)-carbamic acid tert-butyl ester
- Author
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Rama Kant, Alka Agarwal, and Vishal Singh
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chemistry.chemical_compound ,Crystallography ,Carbamic acid ,Materials science ,chemistry ,Hydrogen bond ,Carbazole ,Amide ,General Physics and Astronomy ,Moiety ,Dihedral angle ,Single crystal ,Monoclinic crystal system - Abstract
The title compound (9-ethyl-9H-carbazol-3-yl)-carbamic acid tert-butyl ester was prepared from 3-amino-9-ethylcarbazole and di-tert-butyldicarbonate (Boc anhydride) in good yield. It was characterized by elemental analysis, FT-NMR, FT-IR spectroscopy and subjected to single crystal X-ray diffraction studies. The compound crystallizes in monoclinic space group P21/c with unit cell dimensions are a = 13.5218(8) A, b = 12.7624(7) A, c = 10.1352(6) A, β = 100.784(6)°, V = 1718.15(17) A3, D x = 1.200 Mg m−3, and Z = 4. According to X-ray diffraction studies the molecule is in a non planar conformation except for the carbazole moiety and having a dihedral angle of 30.239(89)° between the plane of the carbazole and amide moieties. The molecules are packed in a zig-zag manner and strong N–H···O [C(4) motif] intermolecular hydrogen bonding, weak C–H···π [C(5) motif] and π–π stacking interaction stabilize the crystal packing. The thermal analysis of single crystal was determined by DSC and TGA. more...
- Published
- 2015
- Full Text
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37. An expedient approach to 1,2-dihydroisoquinoline derivatives via cobalt catalysed 6-endo dig cyclization followed by Mannich condensation of o-alkynylarylaldimines
- Author
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Vibha Tandon, Sandeep K. Ginotra, Alka Agarwal, Urvashi, and Gaurav K. Rastogi
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Models, Molecular ,Nitromethane ,Chemistry ,Organic Chemistry ,Kinetics ,Molecular Conformation ,chemistry.chemical_element ,Stereoisomerism ,Cobalt ,Isoquinolines ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,Cyclization ,Alkynes ,Dig ,Nitro ,Acetone ,Organic chemistry ,Amines ,Physical and Theoretical Chemistry - Abstract
A highly effective 6-endo dig cyclisation of o-alkynylaldimines to 1,2-dihydroisoquinolines has been described via direct and nitro Mannich condensation using inexpensive and readily available cobalt chloride as catalyst. This strategy provides an effective procedure for the synthesis of substituted 1,2-dihydroisoquinolines derivatives in moderate to high yields. An addition of pronucleophiles, such as nitromethane, acetone and α-hydroxyacetone, to o-alkynylarylaldimines has been achieved via isoquinolinium intermediate. more...
- Published
- 2015
- Full Text
- View/download PDF
38. In vitro antimicrobial activity of o-phenylenediamine-tert-butyl-N-1,2,3-triazole carbamate analogs
- Author
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Gopal Nath, Manavendra K. Singh, Dharmendra Kumar, Alka Agarwal, Mayank Gangwar, and Ragini Tilak
- Subjects
biology ,Stereochemistry ,Chemistry ,Organic Chemistry ,Aspergillus niger ,Antimicrobial ,biology.organism_classification ,Enterococcus faecalis ,Aspergillus fumigatus ,Candida tropicalis ,Candida krusei ,General Pharmacology, Toxicology and Pharmaceutics ,Antibacterial activity ,Candida albicans - Abstract
In an attempt to design and synthesize effective antimicrobial agents using click chemistry, mono- and di-alkyne-substituted monoboc protected o-phenylenediamines were reacted with different substituted aryl azides which yielded 18 new compounds (4a–4k and 5a–5f, 5l). Structures of all newly synthesized compounds were established by 1H and 13C NMR analysis. The intermediate compound 1 was also confirmed by X-ray crystallography. The title compounds were screened for their antibacterial activity against Gram +ve bacteria (Staphylococcus aureus and Enterococcus faecalis), Gram −ve bacteria (Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa), and their antifungal profile were tested on (Candida tropicalis, Candida albicans, Candida krusei, and Cryptococcus neoformans) as well as on molds such as (Aspergillus niger, Aspergillus fumigatus). The compounds 4k and 5f both showed maximum potency against S. aureus (ATCC 25323) strain with MIC value of 6.25 µg/ml, which is comparable with standard drug ciprofloxacin (MIC 6.25 µg/ml) while remaining compounds showed moderate to weak activity. Further, all compounds showed average antifungal activity in the range of 100–200 µg/ml. more...
- Published
- 2014
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39. Modified Two Phase Clocked Adiabatic Static CMOS Logic
- Author
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Swati Dhamani, Praveer Saxena, and Alka Agarwal
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Adder ,OR gate ,Power–delay product ,AND-OR-Invert ,Pass transistor logic ,Computer science ,Real-time computing ,NAND gate ,Hardware_PERFORMANCEANDRELIABILITY ,Capacitance ,law.invention ,law ,Hardware_INTEGRATEDCIRCUITS ,Electronic engineering ,Hardware_ARITHMETICANDLOGICSTRUCTURES ,Adiabatic process ,Electronic circuit ,Adiabatic circuit ,Delay calculation ,Transistor ,Logic family ,Propagation delay ,NAND logic ,XNOR gate ,CMOS ,Logic gate ,Inverter ,XOR gate ,AND gate ,Gate equivalent ,Hardware_LOGICDESIGN ,NOR gate - Abstract
the past decade, various adiabatic logic techniques have been proposed by various authors. One of the widely known adiabatic logic style is Two Phase Clocked Adiabatic Static CMOS Logic (2PASCL). The logic circuits based on 2PASCL suffer from floating output node due to alternate hold phase in its operation. Keeping a node floating for a long time may result in erroneous node voltage. In this paper a technique to reduce the floating node problem associated with 2PASCL is introduced. Modified 2PASCL is used to design a 2-input NAND gate, a 2-input NOR gate and 1- bit full adder at 45nm technology parameters provided by predictive technology and the circuits are simulated using HSPICE. The 2- input NAND gate designed with Modified 2PASCL is compared with the NAND gates designed with 2PASCL and Static CMOS in terms of average power consumed by them for different values of load capacitance and input frequency. NAND gates are also compared in terms of propagation delay, power delay product and the transistor count to implement them. It is observed that the NAND gate based on Modified 2PASCL offer up to 80.3% power saving in comparison to NAND gate based on static CMOS and also exhibit least power delay product. General Terms Adiabatic Logic, Charge Recycling. KeywordsPower, Energy Recovery, Floating Node. more...
- Published
- 2014
- Full Text
- View/download PDF
40. Extensive Juvenile Xanthogranuloma
- Author
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Dayanand Hota, Ashish Amrani, Mahesh Kumar, Sameer Sarswat, Niharika Dixit, and Alka Agarwal
- Subjects
medicine.medical_specialty ,Pediatrics ,Maternal and child health ,business.industry ,Juvenile xanthogranuloma ,Pediatrics, Perinatology and Child Health ,Pediatric surgery ,MEDLINE ,Medicine ,business ,medicine.disease ,Skin pathology - Published
- 2018
- Full Text
- View/download PDF
41. Crystal Structure of {4-[3-(4-Fluoro-phenyl)-acryloyl]-phenyl}-carbamic acid tert-butyl ester
- Author
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Alka Agarwal, Manaverdra Kumar Singh, and Charu Mahawer
- Subjects
chemistry.chemical_classification ,Crystallography ,chemistry.chemical_compound ,Carbamic acid ,Double bond ,Chemistry ,Hydrogen bond ,Intermolecular force ,General Physics and Astronomy ,Molecule ,Orthorhombic crystal system ,Crystal structure ,Dihedral angle - Abstract
The crystal structure of {4-[3-(4-fluoro-phenyl)-acryloyl]-phenyl}-carbamic acid tert-butyl ester has been determined by X-ray diffraction, title compound crystallized in orthorhombic, P21/n space group with unit cell parameters a = 10.100(3) A, b = 18.201(5) A, c = 10.829(3) A; α = 90°, β = 111.15(4)°, γ = 90°. The crystal structure of compound was stabilized by N–H…O intermolecular hydrogen bonding, the molecules are linked by C–H…F, C–H…O and C–H…H–C intermolecular interactions. The two benzenes rings are non planar with dihedral angle 11.11° and contains a single C=C double bond in a trans (E) configuration. more...
- Published
- 2013
- Full Text
- View/download PDF
42. Matlab Based Analysis of 3-Ø Self-Excited Induction Generator with Nonlinear Load
- Author
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Alka Agarwal, Vinesh Agarwal, and Shani Khandelwa
- Subjects
Generator (circuit theory) ,Electric power system ,Rectifier ,Computer science ,Control theory ,Harmonics ,Induction generator ,Fast Fourier transform ,MATLAB ,computer ,Induction motor ,computer.programming_language - Abstract
In this paper MATLAB based steady-state analysis of self excited induction generator is presented and different test models are given to calculate the all parameters which are required in 3-ɸ cage induction motor working as a generator in the self-excited mode of operation. It is well known that, harmonics are generated at the input side of the induction generator due to the presence of nonlinear circuits (rectifier circuit). In this paper, the various nonlinear loads (rectifier loads) connected with the SEIG are simulated and evaluated. The fast Fourier transform (FFT) algorithm is used to analyze the harmonic voltages and currents under steady-state conditions. Simulation is carried out for the proposed system using MATLAB/Simulink software power system tools. Index Terms- SEIG, Total harmonics distortion, Harmonics Factor, FFT. more...
- Published
- 2013
- Full Text
- View/download PDF
43. Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1,2,3-triazole conjugates as potent antibacterial agents
- Author
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Vishal Singh, Gopal Nath, Satish Kumar Awasthi, Alka Agarwal, and Rama Kant
- Subjects
Drug ,1,2,3-Triazole ,Stereochemistry ,medicine.drug_class ,media_common.quotation_subject ,Antibiotics ,Chemistry Techniques, Synthetic ,Microbial Sensitivity Tests ,010402 general chemistry ,Gram-Positive Bacteria ,01 natural sciences ,Hemolysis ,chemistry.chemical_compound ,Structure-Activity Relationship ,Ciprofloxacin ,Drug Discovery ,Gram-Negative Bacteria ,medicine ,Humans ,media_common ,Pharmacology ,biology ,010405 organic chemistry ,Organic Chemistry ,General Medicine ,Triazoles ,biology.organism_classification ,Combinatorial chemistry ,0104 chemical sciences ,Anti-Bacterial Agents ,Design synthesis ,chemistry ,Drug Design ,Antibacterial activity ,Bacteria ,Conjugate ,medicine.drug - Abstract
A series of new bis-1,2,3-triazole linked ciprofloxacin conjugates was designed, synthesized and evaluated in vitro antibacterial activity against a panel of clinically relevant bacteria. A significant part of the compounds displayed enhanced activity against both Gram-positive and Gram-negative species of bacteria as compared to the parent drug. Additionally, negligible toxicity profile of compounds indicates that they may act a good antibiotic in future. Despite relatively small number of synthesized conjugates, it was possible to observe important dependences between their structure and activity. more...
- Published
- 2016
44. Design and Analysis of Low Pass Elliptic Filter
- Author
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Rajat Sheel Jain, Alka Agarwal, Faisal Ali, and Gupta Deepti S
- Subjects
Computer science ,business.industry ,Low-pass filter ,Butterworth filter ,Relative permittivity ,02 engineering and technology ,Substrate (printing) ,Microstrip ,Noise ,020204 information systems ,Hardware_INTEGRATEDCIRCUITS ,0202 electrical engineering, electronic engineering, information engineering ,Electronic engineering ,020201 artificial intelligence & image processing ,Elliptic filter ,Telecommunications ,business - Abstract
Low pass filters are used for removing random or periodic noise, modifying signals before analog to digital conversion, blurring of images and so on. This paper describes the design of a Low Pass Elliptic filter by using microstrip layout which works at 3.6GHz cut-off frequency for relative permittivity of 3.6 with a substrate thickness of 1.6mm. Microstrip technology is used for simplicity, low cost and ease of fabrication. The designing and simulation are performed using Computer Simulation Technology Microwave Studio. more...
- Published
- 2016
- Full Text
- View/download PDF
45. Synthesis and in vitro antiplasmodial activities of fluoroquinolone analogs
- Author
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Alka Agarwal, Satish K. Awasthi, Virendra K. Bhasin, Manish Sharma, Shailja Singh, Sandeep K. Dixit, and Nidhi Mishra
- Subjects
Cell Survival ,medicine.drug_class ,Plasmodium falciparum ,Chemistry Techniques, Synthetic ,Pharmacology ,Antimalarials ,Inhibitory Concentration 50 ,Chloroquine ,Drug Discovery ,medicine ,Humans ,Severe Malaria ,IC50 ,biology ,Chemistry ,Organic Chemistry ,General Medicine ,Triazoles ,biology.organism_classification ,Quinolone ,In vitro ,Ciprofloxacin ,HEK293 Cells ,Click chemistry ,Fluoroquinolones ,medicine.drug - Abstract
Fluoroquinolone analogs were synthesized by simple alkylation followed by click chemistry and evaluated for their antimalarial in vitro against chloroquine sensitive strain of Plasmodium falciparum while ciprofloxacin was used as standard. Our results showed that the compound 12 was found most active with IC50 value of 1.33 μg/mL while ciprofloxacin showed IC50 = 8.81 μg/mL. Therefore, screening of either known or unknown quinolone/fluoroquinolone analogs are worthwhile to find more potent antimalarial drugs which might prove useful in the treatment of mild or severe malaria in human either alone or in combination with existing antimalarial drugs. more...
- Published
- 2012
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46. Knowledge, attitude and practice of epilepsy in Uttarakhand, India
- Author
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Deepak Goel, V. Mehlotra, Alka Agarwal, Vijay Laxmi Saxena, and JS Dhanai
- Subjects
medicine.medical_specialty ,knowledge ,Epilepsy ,business.industry ,Short Communication ,Alternative medicine ,Mental disease ,Negative attitude ,Special education ,medicine.disease ,attitude and practice ,lcsh:RC346-429 ,epilepsy in India ,Officer ,Family medicine ,medicine ,Neurology (clinical) ,Psychiatry ,business ,lcsh:Neurology. Diseases of the nervous system - Abstract
Objectives: This study was conducted to find out knowledge, attitude and practice (KAP) of epilepsy among 12 th -class students in Uttarakhand state. Secondly data of Uttarakhand was compared with KAP study from other parts of the country. Materials and Methods: All 12 th - class students studying in six schools of randomly selected 36 villages in Chakrata block of Dehradun district of Uttarakhand state were provided a printed questionnaire having answer as "yes or no". This questionnaire used was used previously by various authors and validated for KAP analysis. These filled questionnaires were collected by village health workers and medical officer. Results: This study conducted on 219, 12 th -class students revealed that epilepsy was heard by 98%, 74.9% thought epilepsy a mental disease and 4.8% believed that it is contagious. Negative attitude showed as nearly 2/3 rd students stated that epilepsy is hindrance in marriage and occupation. Nearly 41% would use onion or shoe for terminating seizure attack. Ayurvedic treatment was preferred over allopathic drugs. Conclusions: Study on 12 th -class students of Uttarakhand revealed poor knowledge, attitude and practice for epilepsy and needs special education program to dispel these misconceptions. more...
- Published
- 2011
47. In vivo antifilarial activity of some cyclic and acylic alcohols
- Author
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Satish Kumar Awasthi, Alka Agarwal, and Pratima Murthy
- Subjects
Acanthocheilonema viteae ,biology ,Chemistry ,Organic Chemistry ,Brugia timori ,Cyclohexanol ,medicine.disease_cause ,biology.organism_classification ,medicine.disease ,Brugia malayi ,chemistry.chemical_compound ,Wuchereria bancrofti ,Biochemistry ,In vivo ,medicine ,Parasite hosting ,General Pharmacology, Toxicology and Pharmaceutics ,Lymphatic filariasis - Abstract
The filarial nematodes, Wuchereria bancrofti, Brugia malayi, and Brugia timori are the causative agents of lymphatic filariasis. 2-Substituted propanol, cyclohexanol, and cyclooctanol compounds were evaluated for microfilaricidal and macrofilaricidal activity in vivo against Acanthocheilonema viteae and Litomosoides carinii in rodents. In the cyclohexanol series, 2-(piperidin-1-yl) cyclohexanol (2b) showed 88.9% macrofilaricidal activity against A. viteae in vivo, while cyclooctanol series, 2-(4-benzyl piperdin-1-yl) cyclooctanol (2f) showed 100% macrofilaricidal activity against A. viteae. Further, compounds 1-(furan-2-ylamino) ethanol (4a) and 1-(4-benzylpiperidin-1-yl)-ethyl acetate (5b) showed 81.3% and 83.4% macrofilaricidal activity, respectively, against the same parasite. Interestingly, compounds 2f and 4a showed significant sterilization of female worms in A. viteae. However, these compounds were found inactive against L. carinii. Therefore, the new class of compounds appeared to have promising antifilarial activity. more...
- Published
- 2010
- Full Text
- View/download PDF
48. Differential regulation of cholesterol homeostasis in transgenic mice expressing human cholesterol ester transfer proteinThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute
- Author
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Cathy M. Murray, Alka Agarwal-Mawal, Sukhinder K. Cheema, and Suresh BelkhodeS. Belkhode
- Subjects
Pharmacology ,Genetically modified mouse ,chemistry.chemical_classification ,medicine.medical_specialty ,biology ,Triglyceride ,Physiology ,Cholesterol ,Ratón ,food and beverages ,General Medicine ,Microsomal triglyceride transfer protein ,carbohydrates (lipids) ,chemistry.chemical_compound ,Endocrinology ,Enzyme ,chemistry ,Physiology (medical) ,Internal medicine ,Cholesterylester transfer protein ,biology.protein ,medicine ,lipids (amino acids, peptides, and proteins) ,Homeostasis - Abstract
We investigated whether expression of cholesterol ester transfer protein (CETP) in mice alters the regulation of cholesterol metabolism. Transgenic mice expressing human CETP (CETP-TG) and nontransgenic littermates (non-TG) were fed either a monounsaturated fatty acid (MUFA) or a saturated fatty acid (SFA)-rich diet in the presence or absence of cholesterol. Mice fed with MUFA diet had higher CETP activity compared with SFA-fed mice. Addition of cholesterol to the MUFA diet decreased CETP activity, whereas addition of cholesterol to the SFA diet had no effect. Cholesterol 7α-hydroxylase (Cyp7a) activity was higher in CETP-TG mice compared with non-TG mice when fed a MUFA diet, whereas SFA fed CETP-TG mice showed lower Cyp7a activity as compared with non-TG. Microsomal triglyceride transfer protein (MTTP) activity was higher in CETP-TG mice compared with non-TG mice when fed a MUFA diet. HMG-CoA reductase activity was lower in CETP-TG mice compared with non-TG mice when fed a MUFA or a SFA diet. These data demonstrate that the regulation of Cyp7a, HMG-CoA reductase, and MTTP is altered in CETP-TG mice as compared with non-TG mice and these alterations are further modulated by the quality of dietary fats. These findings highlight the importance of CETP in regulating cholesterol homeostasis. more...
- Published
- 2007
- Full Text
- View/download PDF
49. Characterization and multi-generational stability of the growth hormone transgene (EO-1α) responsible for enhanced growth rates in Atlantic Salmon
- Author
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Edward S. Yaskowiak, Margaret A. Shears, Alka Agarwal-Mawal, and Garth L. Fletcher
- Subjects
Genetics ,Animal Science and Zoology ,Agronomy and Crop Science ,Biotechnology - Published
- 2007
- Full Text
- View/download PDF
50. Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities
- Author
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Rinkoo D. Gupta, Satish Kumar Awasthi, Alka Agarwal, Rama Kant, Dharmendra Kumar, Drishti Agarwal, and Ragini Tilak
- Subjects
Chalcone ,Antifungal Agents ,Plasmodium falciparum ,Microbial Sensitivity Tests ,010402 general chemistry ,Candida parapsilosis ,01 natural sciences ,Enterococcus faecalis ,Microbiology ,Aspergillus fumigatus ,Candida tropicalis ,chemistry.chemical_compound ,Antimalarials ,Structure-Activity Relationship ,Parasitic Sensitivity Tests ,Cell Line, Tumor ,Drug Discovery ,Humans ,Candida albicans ,Pharmacology ,biology ,Bacteria ,Dose-Response Relationship, Drug ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,Fungi ,General Medicine ,Triazoles ,biology.organism_classification ,Antimicrobial ,Flavones ,0104 chemical sciences ,Anti-Bacterial Agents ,chemistry ,Biochemistry ,Antibacterial activity - Abstract
The present study was carried out in an attempt to synthesize a new class of antimicrobial and antiplasmodial agents by copper catalyzed click chemistry to afford 25 compounds 10-14(a-e) of 1,4-disubstituted-1,2,3-triazole derivatives of chalcones and flavones. The structures of the newly synthesized compounds were established by elemental analysis, IR, (1)H NMR, (13)C NMR and Mass spectral data. The newly synthesized compounds were evaluated for their antibacterial activity against Gram positive bacteria (Staphylococcus aureus, Enterococcus faecalis), Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Shigella boydii, Klebsiella pneumoniae) and antifungal activity against (Candida albicans, Candida tropicalis, Candida parapsilosis, Cryptococcus neoformans, Dermatophyte) as well as molds (Aspergillus niger, Aspergillus fumigatus). The antiplasmodial and cytotoxic activities of these compounds were also evaluated against human malaria parasite Plasmodium falciparum strain 3D7 and human hepato-cellular carcinoma cells (Huh-7), respectively. Compounds 10a, 10c, 10d, 12c and 14e showed promising antibacterial activity while compounds 10e, 11d, 11e, 12c, 13a, 13b, 13e, 14a and 14d showed good antifungal activity as compared to the corresponding standard drugs. Compound 10b was found to be the most active against Plasmodium falciparum while the remaining compounds showed moderate to weak antiplasmodial activity. However, cytotoxic activities of all compounds were found ineffective against Huh-7 cells. more...
- Published
- 2015
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