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1,2,3-Triazole is one of the most therapeutically privileged heterocyclic systems. In the present work, we report the regioselective synthesis of a new array of trisubstituted 1,2,3-triazoles under metal-free conditions and evaluated their antiradical activity. The title compounds were synthesized according to the well-known [3+2] cycloaddition reaction between benzyl buta-2,3-dienoate (3) and organic azides (5) giving the triazole derivatives 6(a-f). Structures of the synthesized entities corroborated spectroscopically (1H NMR, 13C NMR, and MASS) and screened for antiradical activity using DPPH radical scavenging assay. Among the tested compounds, the highest activity was observed with the 6b derivative.

β-Carboline is also known as nor-harmane. It is a nitrogen-containing heterocyclic compound formed in plants and animals as Maillard reaction products between amino acids and reducing sugars or aldehydes. These tricyclic nitrogen heterocyclics play a vital role in medicinal chemistry, due to significant biological activities of their derivatives. It is also a key pharmacophore present in a large number of natural tricyclic alkaloids. Current work is reported with the synthesis and antibacterial activity screening of a new series of N-Substituted-9H-β-carboline-6-amine derivatives. The title compounds were synthesized according to the well known Pictet Spengler reaction in three steps by taking 5-Chlorotryptamine and glyoxalic acid as starting materials. This is an acid-catalyzed intramolecular condensation of an iminium ion and an aromatic C-nucleophile which resulted in the formation of 6-Chloro-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-ium-1-carboxylate (3). Oxidative decarboxylation and aromatization of compound 3 with iodobenzene diacetate led to the 6-Chloro-β–carboline (4) which were treated with different mono substituted amines gave the title compounds (5 a-J). Structures of the synthesized entities were confirmed spectroscopically (FT-IR, 1H NMR and Mass) and screened for antibacterial activity against various pathogenic bacterial strains ( Streptococcus pyogenes, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) by disc diffusion method. The title compounds showed moderate to good antibacterial activity.

Aim: To synthesize and evaluate 4-aminoantipyrine related schiff’s bases as antibacterial agents. Objective: To synthesize, purify, characterize and evaluate 4-aminoantipyrine. Method: Schiff bases derived from 4-aminoantipyrine play a vital role in biological and pharmacological activities. Knowing the importance of 4-aminoatipyrine schiff bases and their analogues wide varieties of bioactivities like analgesic, antiviral, antipyretic, anti-rheumatic, antimicrobial and anti-inflammatory activities have been widely studied. 4-aminoantipyrine compounds C1 (anisaldehyde), C2 (p-hydroxybenzaldehyde) and C3(vanillin) were prepared by condensation between 4-amino antipyrine and substituted aromatic benzaldehydes. The products were purified by recrystallization by using ethanol, characterized by IR spectroscopy. The N-H stretching in 4-aminoantipyrine is shown at 3430 cm-1 and -3325 cm-1. The -HC=N- stretching is observed in the range of 1508-1504 cm-1 The –OCH3 stretching is found at 1888 cm-1. 4-amino antipyrine related schiff’s bases evaluated their activity as antimicrobials in-vitro by spread plate method against E.coli. Schiff bases have potent antibacterial activity with gram negative bacteria E.coli. Results: Synthesis and characterization of a schiff bases derived from substituted benzaldehydes and 4-aminoantipyrine was evaluated and characterized with the IR spectroscopic techniques and schiff bases have shown potent antibacterial activity against E.Coli.

Heterocyclic analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. s-carboline also known as nor-harmane is a nitrogen containing heterocyclic compound. It belongs to the group of indole alkaloids and consists of pyridine ring that is fused to an indole skeleton. These tricyclic nitrogen heterocyclics are formed in plants and animals as Maillard reaction products between amino acids and reducing sugars or aldehydes. These compounds have special significance in the field of Medicinal chemistry due to their remarkable pharmacological potentialities and their derivatives have attracted a great deal of interest due to their wide range of biological activities such as antimicrobial, antitumor, cytotoxic, antiplasmodial, antioxidant, antimutagenic, antigenotoxic and hallucinogenic properties. It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor, enhances insulin sensitivity and also produces vasorelaxant effect. Harmine prevents bone loss by suppressing osteoclastogenesis. This review is mainly an attempt to present the research work reported in the recent scientific literature focusing on different synthetic methods and pharmacological activities of betacarboline derivatives which may contribute in future to synthesize various analogs and to develop new pharmacologically less toxic medicines.