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Abstract Gelatin-methacryloyl (GelMA) is a highly adaptable biomaterial extensively utilized in skin regeneration applications. However, it is frequently imperative to enhance its physical and biological qualities by including supplementary substances in its composition. The purpose of this study was to fabricate and characterize a bi-layered GelMA-gelatin scaffold using 3D bioprinting. The upper section of the scaffold was encompassed with keratinocytes to simulate the epidermis, while the lower section included fibroblasts and HUVEC cells to mimic the dermis. A further step involved the addition of amniotic membrane extract (AME) to the scaffold in order to promote angiogenesis. The incorporation of gelatin into GelMA was found to enhance its stability and mechanical qualities. While the Alamar blue test demonstrated that a high concentration of GelMA (20%) resulted in a decrease in cell viability, the live/dead cell staining revealed that incorporation of AME increased the quantity of viable HUVECs. Further, gelatin upregulated the expression of KRT10 in keratinocytes and VIM in fibroblasts. Additionally, the histological staining results demonstrated the formation of well-defined skin layers and the creation of extracellular matrix (ECM) in GelMA/gelatin hydrogels during a 14-day culture period. Our study showed that a 3D-bioprinted composite scaffold comprising GelMA, gelatin, and AME can be used to regenerate skin tissues.

Abstract Adding foreign ions to hydroxyapatite (HAp) is a popular approach for improving its properties. This study focuses on the effects of calcium substitution with copper in HAp. Instead of calcium, copper ions were doped into the structure of hydroxyapatite nanoparticles at 1%, 3%, and 5% concentrations. XRD analysis showed that the amount of substituted copper was less than needed to generate a distinct phase, yet its lattice parameters and crystallinity slightly decreased. Further, the results of degradation tests revealed that copper doping in hydroxyapatite doubled calcium ion release in water. The incorporation of copper into the apatite structure also boosted the HAp zeta potential and FBS protein adsorption onto powders. According to antibacterial investigations, a concentration of 200 mg/ml of hydroxyapatite containing 5% copper was sufficient to effectively eradicate E. coli and S. aureus bacteria. Furthermore, copper improved hydroxyapatite biocompatibility. Alkaline phosphatase activity and alizarin red tests showed that copper in hydroxyapatite did not inhibit stem cell differentiation into osteoblasts. Also, the scratch test demonstrated that copper-containing hydroxyapatite extract increased HUVEC cell migration. Overall, our findings demonstrated the utility of incorporating copper into the structure of hydroxyapatite from several perspectives, including the induction of antibacterial characteristics, biocompatibility, and angiogenesis.

Each variation in public transportation system has a direct effect on passengers travel time. It’s due to the integrated, direct and continuous relationship between passengers and public transportation system. In addition to, reduction in travel and waiting time for passengers will increase the use of public transport systems in a metropolitan. On the other hand, now a days, using simulation software, is one of the strongest and most acceptable tools for traffic analysis. In this study the AIMSUN (Advanced Interactive Microscopic Simulator for Urban and non-urban) and Legion software has been used for simulation of pedestrian travel time between a group of urban subway stations from Gheitarieh to Shahid Haqqani. The pedestrian flow in each station, waiting time, boarding, alight and travel time inside the vehicle has been considered too. According to the current schedule of trains, sum of the waiting time for pedestrian will be 15% more than the schedule with 5 minutes headway. Also the 4 minutes headway will cause the 45% decrease in passengers waiting time.

This article presents an optimal placement and sizing of distribution static compensator (DSTATCOM) in radial distribution networks as multi-objective optimization with the objective of power loss reduction, voltage profile improvement and network reliability considering different variable demands using whale optimization algorithm (WOA). The WOA is inspired by the hunting behavior of humpback whales. The optimal location and size of DSTATCOM are considered as decision variables that are determined using the WOA. Network reliability is defined as energy not supplied (ENS) of the customers caused by line outages. The proposed method is implemented on IEEE 33-bus and Ahvaz 59-bus distribution networks. The optimal placement and sizing of DSTATCOM are investigated considering different residential, commercial and industrial loads, and also the effect of incorporating reliability is evaluated on power loss, minimum voltage and ENS. The simulation results show that the power loss and ENS are declined and also voltage profile is improved by determining the location and size of DSTATCOM in the networks in different loading conditions using the WOA. The obtained results demonstrate that considering reliability further reduces the ENS and more customer demand is met. The power loss decreases 21.60%, 30.71%, and 22.03% for residential, commercial and industrial loads in the 33-bus network and 26.86%, 31.94%, and 24.39% for the 69-bus network, respectively compared to base networks. Moreover, the performance of the WOA is compared with previous studies and the results indicate the superiority of the proposed method.

In this paper, multi-objective reactive power compensation based on optimal and simultaneous allocation of capacitors and distribution static compensator (DSTATCOM) in radial distribution networks based on fuzzy decision making is proposed with the aim of reducing power losses cost, reactive investment cost and reducing voltage deviations considering power loss reduction factor (PLRF) to identify candidate buses. Optimal location and size of reactive resources is determined based using multi-objective improved golden ratio optimization algorithm (MOIGROM) inspired by Fibonacci series and improved using nonlinearly inertia weight strategy. This method is performed on a 13 bus distribution network, 69 and 118 buses IEEE standard networks in various scenarios including capacitor allocation only, DSTATCOM allocation only and optimal and simultaneous capacitor and DSTATCOM allocation (hybrid allocation). The simulation results showed that the hybrid allocation has less power losses and voltage deviations in different scenarios using fuzzy decision making based on Pareto front set. Also the impact of different loading conditions on problem solution cleared that with increasing the load level, especially during the heavy load, the power losses and voltage deviations of the networks increase and vice versa. In addition, the advantage of the MOIGROM method over the other methods is confirmed.

Given the range of spirituality in different aspects of human life and the need to evaluate the role of spirituality in quality of life, the aim of the present study is to investigate the relationship between dimensions of quality of life and the dimensions of spiritual intelligence in female nurses working in Ahvaz' hospitals. This study has a descriptive and correlation method. The sample included 200 married female nurses who were selected by stratified random sampling. Data have been gathered by the questionnaires of King Spiritual Intelligence and the World Health Organization Quality of Life Scale (short form). Data have been analyzed by descriptive statistics, Pearson correlation, and multiple regressions. There were a meaningful positive relationship among spiritual intelligence and its dimensions, the personal meaning-production, transcendental consciousness and critical existential thinking with quality of life. However, the personal meaning-production of the spiritual intelligence, conscious state expansion and transcendental consciousness has significant and positive relationship with the quality of life and its components. It can be concluded that the dimensions of spiritual intelligence explained 9.3 percent of the variance quality of life.

Introduction: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral and potentially fatal disease that is endemic in the south east of Iran, especially Sistan and Baluchestan. This study aimed to measure the serum levels of interferon-[1]r (IFN-[1]r) in the patients with CCHF, considering the disseminated intravascular coagulation (DIC) severity. The second aim was to determine the correlation between the serum levels of IFN-[1]r and DIC severity using the guidance of diagnosis and treatment of the CCHF. Methods: Thirty-seven patients with CCHF were studied. The diagnosis was made, based on the detection of viral RNA by real time-polymerase chain reaction (RT-PCR) and by positive serology. These patients, based on the severity of DIC, were divided into two groups. The serum levels of IFN-[1]r were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared between these two groups. Data analysis was performed using the SPSS 20.0 and non-parametric statistical tests were used for analyses. Results: The mean serum levels of IFN-[1]r were lower in the patients with CCHF on the ­rst day compared to the ­fth day of admission (P < 0.008). There was a signi­cant relationship between the serum levels of IFN-[1]r and DIC severity, as the level of IFN-[1]r was lower in the patients with overt DIC (P < 0.001). The serum level of IFN-[1]r in the patients with the overt DIC was 1.04 pg/dL with 90% speci­city and 88% sensitivity. Conclusion: The serum levels of IFN-[1]r were lower in the patients with severe CCHF, and their evaluation may be used as a marker for the diagnosis of disease severity.

Constitutionalisation means entering the legal rule into a group of fundamental rules that the government is obliged to support and implement. In fact, Constitutionalisation is a process of change and transformation that occurs due to the influence of basic norms in different trends of law and it may be as a result of imbuing the set of legal order with these norms. In Iran, some articles of the Criminal Procedure Law approved in 2013 are in conflict with some of the principles of Constitutional law that are related to the Procedure. Based on this, it seems necessary to analyze the existing conflicts and examine the possibility of the criminal judge for referring to the constitutional law and not implementing the legal articles that are in conflict with the constitutional principles. The Constitutionalisation of criminal Procedure gives judges the possibility to refer to the constitutional law in the face of conflicting laws. In addition, it will be possible to invalidate the proceedings and decisions by the higher judicial authorities based on the contradiction of the ordinary law with the constitutional law. One of the tools to achieve this goal is redefining the principles related to criminal Procedure. Redefinition with using Constitutionalisation tool give the possibility to the criminal judges to reach the mentioned results after knowing those principles that govern the criminal Procedure.

The appropriateness of criminal prosecution means that the prosecutor isable to stop the process of prosecution. Namely, the prosecutor does nothave the authority to initiate a prosecution if he believes that investigationwould not serve the interests of justice. In England’s Legal System, theabove- mentioned principle has been considered as one of the mainprinciples applying on the process of prosecution. This principle has notbeen mentioned expressly in Iran's Criminal Procedure Code, but some ofthe provisions of this Code— for example, the fact that the prosecutor canstop the process of prosecution— have confirmed this issue. The draft ofIran ‘s Criminal Procedure Code, which nowadays is passing its final stagesof being approved in the Islamic Consultative Assembly, attempted to basesome provisions of this Code on this principle, although it has someproblems