192 results on '"Aliprantis, Antonios O."'
Search Results
2. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function
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Charles, Julia F, Hsu, Lih-Yun, Niemi, Erene C, Weiss, Arthur, Aliprantis, Antonios O, and Nakamura, Mary C
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Biomedical and Clinical Sciences ,Immunology ,Autoimmune Disease ,Rheumatoid Arthritis ,Arthritis ,Stem Cell Research - Nonembryonic - Human ,Osteoporosis ,Stem Cell Research ,2.1 Biological and endogenous factors ,Underpinning research ,Aetiology ,1.1 Normal biological development and functioning ,Musculoskeletal ,Inflammatory and immune system ,Adoptive Transfer ,Animals ,Antigens ,Differentiation ,Antigens ,Ly ,Bone Diseases ,Metabolic ,Bone Marrow ,CD11b Antigen ,CD4-Positive T-Lymphocytes ,CX3C Chemokine Receptor 1 ,Cell Differentiation ,Cell Proliferation ,Cells ,Cultured ,Coculture Techniques ,Female ,Humans ,Macrophages ,Mice ,Mice ,Inbred BALB C ,Mice ,Inbred C57BL ,Mice ,Transgenic ,Myeloid Progenitor Cells ,Osteoclasts ,Receptor Activator of Nuclear Factor-kappa B ,Receptors ,Chemokine ,Zymosan ,Medical and Health Sciences ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Increased osteoclastic bone resorption leads to periarticular erosions and systemic osteoporosis in RA patients. Although a great deal is known about how osteoclasts differentiate from precursors and resorb bone, the identity of an osteoclast precursor (OCP) population in vivo and its regulatory role in RA remains elusive. Here, we report the identification of a CD11b(-/lo)Ly6C(hi) BM population with OCP activity in vitro and in vivo. These cells, which can be distinguished from previously characterized precursors in the myeloid lineage, display features of both M1 and M2 monocytes and expand in inflammatory arthritis models. Surprisingly, in one mouse model of RA (adoptive transfer of SKG arthritis), cotransfer of OCP with SKG CD4+ T cells diminished inflammatory arthritis. Similar to monocytic myeloid-derived suppressor cells (M-MDSCs), OCPs suppressed CD4+ and CD8+ T cell proliferation in vitro through the production of NO. This study identifies a BM myeloid precursor population with osteoclastic and T cell-suppressive activity that is expanded in inflammatory arthritis. Therapeutic strategies that prevent the development of OCPs into mature bone-resorbing cells could simultaneously prevent bone resorption and generate an antiinflammatory milieu in the RA joint.
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- 2012
3. Gut microbiota induce IGF-1 and promote bone formation and growth
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Yan, Jing, Herzog, Jeremy W., Tsang, Kelly, Brennan, Caitlin A., Bower, Maureen A., Garrett, Wendy S., Sartor, Balfour R., Aliprantis, Antonios O., and Charles, Julia F.
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- 2016
4. Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-Like Receptor-2
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Aliprantis, Antonios O., Yang, Ruey-Bing, Mark, Melanie R., Suggett, Shelly, Devaux, Brigitte, Radolf, Justin D., Klimpel, Gary R., Godowski, Paul, and Zychlinsky, Arturo
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- 1999
5. The intestinal microbiome and skeletal fitness: Connecting bugs and bones
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Charles, Julia F., Ermann, Joerg, and Aliprantis, Antonios O.
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- 2015
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6. NFATc1 in Inflammatory and Musculoskeletal Conditions
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Aliprantis, Antonios O., Glimcher, Laurie H., and Choi, Yongwon, editor
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- 2010
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7. Osteoclasts: more than ‘bone eaters’
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Charles, Julia F. and Aliprantis, Antonios O.
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- 2014
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8. NFATc1 and NFATc2 repress spontaneous osteoarthritis
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Greenblatt, Matthew B., Ritter, Susan Y., Wright, John, Tsang, Kelly, Hu, Dorothy, Glimcher, Laurie H., and Aliprantis, Antonios O.
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- 2013
9. A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK ‐1654 in healthy Japanese adults
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Orito, Yuji, primary, Otani, Naoyuki, additional, Matsumoto, Yuki, additional, Fujimoto, Katsukuni, additional, Oshima, Nobuyuki, additional, Maas, Brian M., additional, Caro, Luzelena, additional, Aliprantis, Antonios O., additional, Cox, Kara S., additional, Tokumaru, Osamu, additional, Kodama, Masaaki, additional, Kudo, Hideo, additional, Imai, Hiromitsu, additional, and Uemura, Naoto, additional
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- 2022
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10. SLC4A2-mediated Cl⁻/HCO₃⁻ exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts
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Coury, Fabienne, Zenger, Serhan, Stewart, Andrew K., Stephens, Sebastien, Neff, Lynn, Tsang, Kelly, Shull, Gary E., Alper, Seth L., Baron, Roland, and Aliprantis, Antonios O.
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- 2013
11. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption
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Charles, Julia F., Coury, Fabienne, Sulyanto, Rosalyn, Sitara, Despina, Wu, Jing, Brady, Nicholas, Tsang, Kelly, Sigrist, Kirsten, Tollefsen, Douglas M., He, Li, Storm, Daniel, and Aliprantis, Antonios O.
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- 2012
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12. Control of bone resorption in mice by Schnurri-3
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Wein, Marc N., Jones, Dallas C., Shim, Jae-Hyuck, Aliprantis, Antonios O., Sulyanto, Rosalyn, Lazarevic, Vanja, Poliachik, Sandra L., Gross, Ted S., and Glimcher, Laurie H.
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- 2012
13. Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets
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Greenblatt, Matthew B., Sargent, Jennifer L., Farina, Giuseppina, Tsang, Kelly, Lafyatis, Robert, Glimcher, Laurie H., Whitfield, Michael L., and Aliprantis, Antonios O.
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- 2012
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14. List of Contributors
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Aliprantis, Antonios O., primary, Bello-Irizarry, Sheila N., additional, Berry, Ryan, additional, Briot, Karine, additional, Charles, Julia F., additional, Choi, Yongwon, additional, Daiss, John L., additional, Dayer, Jean-Michel, additional, de Mesy Bentley, Karen L., additional, Einhorn, Thomas A., additional, Faccio, Roberta, additional, Fretz, Jackie A., additional, Garlet, Gustavo P., additional, Gerstenfeld, Louis C., additional, Geusens, Piet, additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Gravallese, Ellen M., additional, Graves, Dana T., additional, Grčević, Danka, additional, Horowitz, Mark C., additional, Ishii, Masaru, additional, Kayal, Rayyan A., additional, Kikuta, Junichi, additional, Klibansky, Anne, additional, Kovačić, Natasa, additional, Kronenberg, Henry M., additional, Lee, Sun-Kyeong, additional, Lorenzo, Joseph, additional, MacDougald, Ormond, additional, Martin, T. John, additional, Nakamura, Mary C., additional, Nanes, Mark S., additional, Nevius, Erin, additional, Nishitani, Kohei, additional, O’Brien, Charles A., additional, Oates, Thomas, additional, Penninger, Josef Martin, additional, Pereira, João P., additional, Quinn, Julian M.W., additional, Rodeheffer, Matthew S., additional, Roodman, Garson David, additional, Rosen, Clifford J., additional, Roux, Christian, additional, Schett, Georg, additional, Schwarz, Edward M., additional, Sigl, Verena, additional, Silbermann, Rebecca, additional, Sims, Natalie A., additional, Steen, Brandon M., additional, Sylvester, Francisco A., additional, Takayanagi, Hiroshi, additional, Teitelbaum, Steven L., additional, Vella, Anthony T., additional, and Wu, Joy Y., additional
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- 2016
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15. The Origins of the Osteoclast
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Aliprantis, Antonios O., primary, Charles, Julia F., additional, and Nakamura, Mary C., additional
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- 2016
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16. HCO₃⁻/Cl⁻ Anion Exchanger SLC4A2 Is Required for Proper Osteoclast Differentiation and Function
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Wu, Jing, Glimcher, Laurie H., and Aliprantis, Antonios O.
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- 2008
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17. Transcription Factor T-Bet Regulates Skin Sclerosis through Its Function in Innate Immunity and via IL-13
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Aliprantis, Antonios O., Wang, Jingsong, Fathman, John W., Lemaire, Raphael, Dorfman, David M., Lafyatis, Robert, and Glimcher, Laurie H.
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- 2007
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18. Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis
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Maas, Brian M., primary, Lommerse, Jos, additional, Plock, Nele, additional, Railkar, Radha A., additional, Cheung, S.Y. Amy, additional, Caro, Luzelena, additional, Chen, Jingxian, additional, Liu, Wen, additional, Zhang, Ying, additional, Huang, Qinlei, additional, Gao, Wei, additional, Qin, Li, additional, Meng, Jie, additional, Witjes, Han, additional, Schindler, Emilie, additional, Guiastrennec, Benjamin, additional, Bellanti, Francesco, additional, Spellman, Daniel S., additional, Roadcap, Brad, additional, Kalinova, Mariya, additional, Fok-Seang, Juin, additional, Catchpole, Andrew P., additional, Espeseth, Amy S., additional, Stoch, S. Aubrey, additional, Lai, Eseng, additional, Vora, Kalpit A., additional, Aliprantis, Antonios O., additional, and Sachs, Jeffrey R., additional
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- 2021
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19. 1013. Predicting RSV Efficacy for MK-1654 in Temperate and Tropical Climates using MBMA and Clinical Trial Simulation to Account for Seasonal Differences in RSV Force-of-Infection
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Plock, Nele, primary, Lommerse, Jos, additional, Maas, Brian M, additional, Chen, Jingxian, additional, Bellanti, Francesco, additional, Qin, Li, additional, Witjes, Han, additional, Pierrillas, Philippe, additional, Railkar, Radha, additional, Aliprantis, Antonios O, additional, Vora, Kalpit A, additional, Gao, Wei, additional, Caro, Luzelena, additional, Amy Cheung, S Y, additional, and Sachs, Jeffrey R, additional
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- 2021
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20. 998. Forward and Reverse Translational Approaches to Predict Efficacy of the Neutralizing Respiratory Syncytial Virus (RSV) Antibody MK-1654
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Maas, Brian M, primary, Lommerse, Jos, additional, Plock, Nele, additional, Railkar, Radha, additional, Amy Cheung, S Y, additional, Caro, Luzelena, additional, Chen, Jingxian, additional, Liu, Wen, additional, Zhang, Ying, additional, Huang, Qinlei, additional, Gao, Wei, additional, Qin, Li, additional, Meng, Jie, additional, Witjes, Han, additional, Schindler, Emilie, additional, Guiastrennec, Benjamin, additional, Bellanti, Francesco, additional, Spellman, Daniel, additional, Roadcap, Brad, additional, Kalinova, Mariya, additional, Fok-Seang, Juin, additional, Catchpole, Andrew P, additional, Espeseth, Amy, additional, Aubrey Stoch, S, additional, Lai, Eseng, additional, Vora, Kalpit A, additional, Aliprantis, Antonios O, additional, and Sachs, Jeffrey R, additional
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- 2021
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21. Contributors
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Abdellatif, Engy, primary, Abeles, Aryeh M., additional, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adachi, Jonathan D., additional, Adams, Michael A., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Almeida de Jesus, Adriana, additional, Altman, Roy D., additional, Amigo, Mary-Carmen, additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Azevedo, Pedro Ming, additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baines, Colin, additional, Baker, Nancy A., additional, Balogh, Emese, additional, Balsa, Alejandro, additional, Baraliakos, Xenofon, additional, Bardin, Thomas, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Bauch, Angela, additional, Belch, Jill J.F., additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian, additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Bilginer, Yelda, additional, Birnbaum, Julius, additional, Bishop, Felicity L., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonelli, Michael, additional, Bonnick, Sydney L., additional, Boumpas, Dimitrios T., additional, Bozec, Aline, additional, Brasington, Richard D., additional, Braun, Juergen, additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burmester, Gerd-Rüdiger, additional, Burns, Jane C., additional, Burr, David B., additional, Buttgereit, Frank, additional, Bykerk, Vivian P., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chandran, Vinod, additional, Chard, Michael Denis, additional, Chaudhary, Prateek, additional, Chen, Lan X., additional, Choi, Hyon K., additional, Choy, Ernest H., additional, Christopher-Stine, Lisa, additional, Chu, Alvina D., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Clowse, Megan E.B., additional, Coghlan, J. Gerry, additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispín, José C., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cutolo, Maurizio, additional, D'Adamo, Chris, additional, D'Agati, Vivette, additional, D'Cruz, David P., additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalbeth, Nicola, additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, Davis, Aileen M., additional, De Ceulaer, Karel, additional, Deal, Chad L., additional, Deane, Kevin D., additional, Della Rossa, Alessandra, additional, Dellaripa, Paul F., additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Dieppe, Paul, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dvorkina, Olga, additional, Dyer, George S.M., additional, Eastell, Richard, additional, Edwards, N. Lawrence, additional, Emery, Paul, additional, Erturan, Gurhan, additional, Espinoza, Luis R., additional, Eyre, Steve, additional, Fanouriakis, Antonios C., additional, Farber, Joshua, additional, Farrokhi, Shawn, additional, Fasth, Anders, additional, Feist, Eugen, additional, Feldman, Debbie, additional, Felson, David T., additional, Fisk, John D., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Frangos, Jennifer, additional, Freemont, Anthony J., additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gadina, Massimo, additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gensler, Lianne S., additional, Geraldino-Pardilla, Laura, additional, Gerlag, Danielle M., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gladman, Dafna D., additional, Gold, Garry E., additional, Goldbach-Mansky, Raphaela, additional, Goldingay, Sarah, additional, Gordon, Sharon M., additional, Gorodkin, Rachel, additional, Goronzy, Jörg J., additional, Görtz, Simon, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Gujar, Bansari, additional, Hagan, Matilda, additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hall, John C., additional, Hamuryudan, Vedat, additional, Hanly, John G., additional, Hanson, Eric P., additional, Haraoui, Boulos, additional, Harley, John B., additional, Hashkes, Philip J., additional, Hawker, Gillian A., additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Ho, Pauline Y.P., additional, Hochberg, Marc C., additional, Hochman, Jacqueline, additional, Hodgkiss-Harlow, Chelsea J., additional, Hoffman, Robert W., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, Jackson, William, additional, Jaimungal, Sarada, additional, James, Judith A., additional, Javier, Rose-Marie, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kane, David, additional, Kapoor, Mohit, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kottyan, Leah, additional, Koutsogeorgopoulou, Loukia A., additional, Kraus, Virginia Byers, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Lau, Arthur N., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Lewith, George, additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Lundberg, Karin, additional, Machold, Klaus P., additional, MacKenzie, C. Ronald, additional, Mahr, Alfred D., additional, Manheimer, Eric, additional, Marini, Joan C., additional, Marquez, Javier, additional, Marsden, Debbie, additional, Martel-Pelletier, Johanne, additional, Martín-Mola, Emilio, additional, Martínez-Lavín, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Matzat, Stephen J., additional, Mayahi, Reza, additional, Mayes, Maureen Davidica, additional, McAlindon, Timothy, additional, McBain, Hayley, additional, McCarberg, Bill, additional, McCarthy, Edward F., additional, McCarthy, Geraldine, additional, McDermott, Michael F., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Monach, Paul A., additional, Mulligan, Kathleen, additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Naylor, Kim E., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nordal, Ellen, additional, Nöth, Ulrich, additional, Ntatsaki, Eleana, additional, O'Shea, John J., additional, Oddis, Chester V., additional, Olivé, Alejandro, additional, Omair, Mohammed A., additional, Ombrello, Michael J., additional, Omisade, Antonina, additional, Ong, Voon H., additional, Önnerfjord, Patrik, additional, Orcel, Philippe, additional, Ospelt, Caroline, additional, Ozen, Seza, additional, Paget, Stephen A., additional, Patel, Dipak R., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pereira, Rosa Maria Rodrigues, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Price, Andrew, additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ravelli, Angelo, additional, Redmond, Anthony C., additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Requena, Luis, additional, Ribbens, Clio, additional, Richardson, Bruce C., additional, Riera Alonso, Elena, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Ritter, Susan Y., additional, Rosas, Ivan O., additional, Rowan, Drew D., additional, Rudwaleit, Martin, additional, Rull, Marina, additional, Rygg, Marite, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Scher, Jose U., additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schreiber, Benjamin, additional, Schumacher, H. Ralph, additional, Schwartz, Daniella Muallem, additional, Scott, David G.I., additional, Seton, Margaret, additional, Shapiro, Lauren M., additional, Sharby, Nancy, additional, Siegel, Jeffrey, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, Steen, Virginia D., additional, Steere, Allen C., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stojan, George, additional, Stone, John H., additional, Strand, Vibeke, additional, Straub, Rainer H., additional, Streeten, Elizabeth A., additional, Superti-Furga, Giulio, additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltan, additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thomas, Sarah S., additional, Thorne, Jennifer E., additional, Tobias, Jonathan H., additional, Tremoulet, Adriana H., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Unizony, Sebastian H., additional, Valdes, Ana M., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Vollenhoven, Ronald Frits, additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vital, Edward M., additional, Walker-Bone, Karen, additional, Wallace, Daniel J., additional, Warburton, Gary, additional, Ward, Robert J., additional, Watts, Richard, additional, Wechalekar, Mihir D., additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Winthrop, Kevin L., additional, Wong, John B., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Xu, Huji, additional, Yazici, Hasan, additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional
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- 2015
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22. Relapsing polychondritis
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Ritter, Susan Y., primary and Aliprantis, Antonios O., additional
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- 2015
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23. The Immune Pathogenesis of Scleroderma: Context Is Everything
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Greenblatt, Matthew B. and Aliprantis, Antonios O.
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- 2013
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24. Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
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Jones, Dallas, Glimcher, Laurie H., and Aliprantis, Antonios O.
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Osteoporosis -- Development and progression -- Research ,Immune response -- Physiological aspects -- Research ,Arthritis -- Development and progression -- Research ,Health care industry - Abstract
Over the past decade and a half, the biomedical community has uncovered a previously unappreciated reciprocal relationship between cells of the immune and skeletal systems. Work in this field, which [...]
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- 2011
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25. HC[O.sub.3.sup.-]/[Cl.sup.-] anion exchanger SLC4A2 is required for proper osteoclast differentiation and function
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Wu, Jing, Glimcher, Laurie H., and Aliprantis, Antonios O.
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Anion exchangers (Biology) -- Usage ,Osteoclasts (Biology) -- Properties ,Science and technology - Abstract
As the only cell capable of bone resorption, the osteoclast is a central mediator of skeletal homeostasis and disease. To efficiently degrade mineralized tissue, these multinucleated giant cells secrete acid into a resorption lacuna formed between their apical membrane and the bone surface. For each proton pumped into this extracellular compartment, one bicarbonate ion remains in the cytoplasm. To prevent alkalinization of the cytoplasm, a basolateral bicarbonate/chloride exchanger provides egress for intracellular bicarbonate. However, the identity of this exchanger is unknown. Here, we report that the bicarbonate/chloride exchanger, solute carrier family 4, anion exchanger, member 2 (SLC4A2), is up-regulated during osteoclast differentiation. Suppression of Slc4a2 expression by RNA interference inhibits the ability of RAW cells, a mouse macrophage cell line, to differentiate into osteoclasts and resorb mineralized matrix in vitro. Accordingly, Slc4a2-deficient mice fail to remodel the primary, cartilaginous skeletal anlagen. Abnormal multinucleated giant cells are present in the bone marrow of Slc4a2-deficient mice. Though these cells express the osteoclast markers CD68, cathepsin K, and NFATc1, compared with their wild-type (WT) counterparts they are larger, fail to express tartrate-resistant acid phosphatase (TRAP) activity, and display a propensity to undergo apoptosis. In vitro Slc4a2-deficient osteoclasts are unable to resorb mineralized tissue and cannot form an acidified, extracellular resorption compartment. These data highlight SLC4A2 as a critical mediator of osteoclast differentiation and function in vitro and in vivo. apoptosis | NFATc1 | osteopetrosis | acidification
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- 2008
26. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism
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Aliprantis, Antonios O., Ueki, Yasuyoshi, Sulyanto, Rosalyn, Park, Arnold, Sigrist, Kirsten S., Sharma, Sudarshana M., Ostrowski, Michael C., Olsen, Bjorn R., and Glimcher, Laurie H.
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Bone morphogenetic proteins -- Physiological aspects ,Bone morphogenetic proteins -- Genetic aspects ,Bone morphogenetic proteins -- Research ,Cytokines -- Health aspects ,Gene expression -- Research ,Osteoporosis -- Genetic aspects ,Osteoporosis -- Care and treatment ,Osteoporosis -- Prevention ,Osteoporosis -- Research - Abstract
Osteoporosis results from an imbalance in skeletal remodeling that favors bone resorption over bone formation. Bone matrix is degraded by osteoclasts, which differentiate from myeloid precursors in response to the cytokine RANKL. To gain insight into the transcriptional regulation of bone resorption during growth and disease, we generated a conditional knockout of the transcription factor nuclear factor of activated T cells c1 (Nfatc1). Deletion of Nfatc1 in young mice resulted in osteopetrosis and inhibition of osteoclastogenesis in vivo and in vitro. Transcriptional profiling revealed NFATc1 as a master regulator of the osteoclast transcriptome, promoting the expression of numerous genes needed for bone resorption. In addition, NFATc1 directly repressed osteoclast progenitor expression of osteoprotegerin, a decoy receptor for RANKL previously thought to be an osteoblast-derived inhibitor of bone resorption. "Cherubism mice", which carry a gain-of-function mutation in SH3-domain binding protein 2 (Sh3bp2), develop osteoporosis and widespread inflammation dependent on the proinflammatory cytokine, TNF-[alpha]. Interestingly, deletion of Nfatc1 protected cherubism mice from systemic bone loss but did not inhibit inflammation. Taken together, our study demonstrates that NFATc1 is required for remodeling of the growing and adult skeleton and suggests that NFATc1 may be an effective therapeutic target for osteoporosis associated with inflammatory states., Introduction Osteoporosis, the most common pathologic condition resulting from excessive bone destruction, afflicts 10 million Americans over the age of 50 and results in 1.5 million fractures annually (1), (2). [...]
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- 2008
27. NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
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Horsley, Valerie, Aliprantis, Antonios O., Polak, Lisa, Glimcher, Laurie H., and Fuchs, Elaine
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Stem cells ,Biological sciences - Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2007.11.047 Byline: Valerie Horsley (1), Antonios O. Aliprantis (2)(3), Lisa Polak (1), Laurie H. Glimcher (2)(3), Elaine Fuchs (1) Keywords: STEMCELL; CELLCYCLE Abstract: Quiescent adult stem cells reside in specialized niches where they become activated to proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP signaling upstream and it acts downstream to transcriptionally repress CDK4 and maintain stem cell quiescence. As stem cells become activated during hair growth, NFATc1 is downregulated, relieving CDK4 repression and activating proliferation. When calcineurin/NFATc1 signaling is suppressed, pharmacologically or via complete or conditional NFATc1 gene ablation, stem cells are activated prematurely, resulting in precocious follicular growth. Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence. Author Affiliation: (1) Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA (2) Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA 02115, USA (3) Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Article History: Received 26 June 2007; Revised 28 September 2007; Accepted 26 November 2007 Article Note: (miscellaneous) Published: January 24, 2008
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- 2008
28. Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues
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Ritter, Susan Y., Subbaiah, Roopashree, Bebek, Gurkan, Crish, James, Scanzello, Carla R., Krastins, Bryan, Sarracino, David, Lopez, Mary F., Crow, Mary K., Aigner, Thomas, Goldring, Mary B., Goldring, Steven R., Lee, David M., Gobezie, Reuben, and Aliprantis, Antonios O.
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- 2013
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29. Relapsing polychondritis
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Aliprantis, Antonios O., primary and Luthra, Harvinder S., additional
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- 2011
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30. Contributors
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Abeles, Aryeh M., primary, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adams, Michael A., additional, Adlam, David M., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aksentijevich, Ivona, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Allaart, Cornelia F., additional, Allen, Pamela G., additional, Altman, Roy D., additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baker, Nancy, additional, Balsa, Alejandro, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Becker, Michael A., additional, Belch, Jill JF, additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benitez, R. Michael, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian M., additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Blazar, Philip E., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Boileau, Christelle, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonnick, Sydney, additional, Boumpas, Dimitrios T., additional, Brasington, Richard D., additional, Breedveld, Ferdinand, additional, Brien, Earl W., additional, Brower, Anne C., additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burns, Jane C., additional, Burr, David B., additional, Cagnoli, Patricia C., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Canoso, Juan J., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chard, Michael Denis, additional, Chen, Lan X., additional, Choy, Ernest H.S., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Colburn, Nona T., additional, Coleman, Laura A., additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Cosman, Felicia, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispin, José C., additional, Criswell, Lindsey A., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cush, John J., additional, Cutolo, Maurizio, additional, D’Agati, Vivette, additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, David, Jean-Pierre, additional, Davis, Aileen, additional, Deal, Chad L., additional, De Ceulaer, Karel, additional, Deighton, Chris, additional, Dellaripa, Paul F., additional, Rossa, Alessandra Della, additional, Dempster, David, additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Denton, John, additional, Dhawale, Roshan, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dooley, Mary Anne, additional, Dougados, Maxime, additional, Drummond, Michael F., additional, Dyer, George S.M., additional, Earp, Brandon E., additional, Edwards, N. Lawrence, additional, Ellender, Patrick, additional, Emery, Paul, additional, Espinoza, Luis R., additional, Farber, Joshua M., additional, Fasth, Anders, additional, Feldman, Debbie, additional, Felson, David T., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Freemont, Anthony J., additional, Fresko, Izzet, additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gabriel, Sherine E., additional, Galarraga, Bernat, additional, Gäre, Boel Andersson, additional, Garnero, Patrick, additional, Gensler, Lianne S., additional, Gerlag, Danielle M., additional, Geusens, Piet P., additional, Giles, Jon T., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gold, Garry, additional, Gonzalez-Rivera, Tania, additional, Gordon, Caroline, additional, Gorodkin, Rachel, additional, Goronzy, Jorg J., additional, Görtz, Simon, additional, Gournelos, Elena, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hamuryudan, Vedat, additional, Haraoui, Boulos, additional, Harder, Adam, additional, Harley, John B., additional, Harris, E. Nigel, additional, Hashkes, Philip J., additional, Hawker, Gillian, additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Heller, Jenny E., additional, Herrick, Ariane L., additional, Higgins, Laurence D., additional, Gaston, J. S. Hill, additional, Hochberg, Marc C., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Huizinga, Tom W.J., additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, James, Hayley, additional, Javier, Rose-Marie, additional, Jayne, David, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Joy, Melanie S., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kanno, Yuka, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kavanaugh, Arthur, additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kim, Peter W., additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kraus, Virginia Byers, additional, Kremers, Hillal Maradit, additional, Krug, Hollis Elaine, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landau, Talia, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Leirisalo-Repo, Marjatta, additional, Lewith, George T., additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lockshin, Michael D., additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Luthra, Harvinder S., additional, Machold, Klaus P., additional, Mackenzie, C. Ronald, additional, Mahowald, Maren Lawson, additional, Mahr, Alfred D., additional, Marini, Joan C., additional, Markalanda, Eresha, additional, Marquez, Javier, additional, Martel-Pelletier, Johanne, additional, Martin-Mola, Emilio, additional, Martinez-Lavin, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Mayes, Maureen, additional, Mayosi, Bongani M., additional, McAlindon, Timothy, additional, McCallum, Rex M., additional, McCarthy, Geraldine, additional, McCune, W. Joseph, additional, McGann, Stephany A., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Mease, Philip J., additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Mitsias, Dimitris I., additional, Mody, Girish M., additional, Monach, Paul A., additional, Moreland, Larry W., additional, Moutsopoulos, Haralampos M., additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Nashel, David J., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nossent, Johannes C., additional, Nöth, Ulrich, additional, O’Connor, Philip, additional, Oddis, Chester V., additional, Olsson, K. Sigvard, additional, Ombrello, Michael J., additional, Orcel, Philippe, additional, O'Shea, John J., additional, Paget, Stephen A., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pierangeli, Silvia, additional, Pierce, Heather, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ramani, Gautam, additional, Ravelli, Angelo, additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Repo, Heikki, additional, Requena, Luis, additional, Ribbens, Clio, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Rosas, Ivan O., additional, Roubenoff, Ronenn, additional, Rowan, A.D., additional, Rudwaleit, Martin, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salonen, David C., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Sanofsky, Benjamin, additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schon, Lew C., additional, Schumacher, H. Ralph, additional, Scott, David G.I., additional, Seidelmann, Brooke, additional, Sestak, Andrea L., additional, Seton, Margaret, additional, Shadick, Nancy A., additional, Shapiro, Lauren, additional, Shi, Lewis L., additional, Sidiropoulos, Prodromos, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Sims, John, additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, St. Clair, E. William, additional, Steen, Virginia D., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stone, John H., additional, Stone, Millicent A., additional, Straub, Rainer H., additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltán, additional, Szer, Ilona S., additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thabet, Mohamed M., additional, Thorne, Jennifer E., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Tzioufas, Athanasios G., additional, Uber, Patricia A., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Gaalen, Floris A., additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vasudevan, Archana R., additional, Venables, Patrick J.W., additional, Vital, Edward M., additional, Wakefield, Richard J., additional, Walker, Jennifer G., additional, Ward, Robert J., additional, Watts, Richard, additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Williams, Frances M.K., additional, Winthrop, Kevin L., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Wright, John, additional, Yazici, Hasan, additional, Yazici, Yusuf, additional, York, John R., additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhai, Guangju, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional
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- 2011
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31. NFATc1 in Inflammatory and Musculoskeletal Conditions
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Aliprantis, Antonios O., primary and Glimcher, Laurie H., additional
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- 2009
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32. A Phase 1 Randomized, Double‐Blind, Placebo‐Controlled Trial to Assess the Safety, Tolerability, and Pharmacokinetics of a Respiratory Syncytial Virus Neutralizing Monoclonal Antibody MK‐1654 in Healthy Adults
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Aliprantis, Antonios O., primary, Wolford, Dennis, additional, Caro, Luzelena, additional, Maas, Brian M., additional, Ma, Hua, additional, Montgomery, Diana L., additional, Sterling, Laura M., additional, Hunt, Allen, additional, Cox, Kara S., additional, Vora, Kalpit A., additional, Roadcap, Brad A., additional, Railkar, Radha A., additional, Lee, Andrew W., additional, Stoch, S. Aubrey, additional, and Lai, Eseng, additional
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- 2020
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33. A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults
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Aliprantis, Antonios O., primary, Shaw, Christine A., additional, Griffin, Paul, additional, Farinola, Nicholas, additional, Railkar, Radha A., additional, Cao, Xin, additional, Liu, Wen, additional, Sachs, Jeffrey R., additional, Swenson, Christine J., additional, Lee, Heather, additional, Cox, Kara S., additional, Spellman, Daniel S., additional, Winstead, Colleen J., additional, Smolenov, Igor, additional, Lai, Eseng, additional, Zaks, Tal, additional, Espeseth, Amy S., additional, and Panther, Lori, additional
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- 2020
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34. Transcriptional regulation of bone and joint remodeling by NFAT
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Sitara, Despina and Aliprantis, Antonios O.
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- 2010
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35. The Regulation of Apoptosis by Microbial Pathogens
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Moss, Jeremy E., primary, Aliprantis, Antonios O., additional, and Zychlinsky, Arturo, additional
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- 1999
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36. A Phase 1 Randomized, Double‐Blind, Placebo‐Controlled Trial to Assess the Safety, Tolerability, and Pharmacokinetics of a Respiratory Syncytial Virus Neutralizing Monoclonal Antibody MK‐1654 in Healthy Adults.
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Aliprantis, Antonios O., Wolford, Dennis, Caro, Luzelena, Maas, Brian M., Ma, Hua, Montgomery, Diana L., Sterling, Laura M., Hunt, Allen, Cox, Kara S., Vora, Kalpit A., Roadcap, Brad A., Railkar, Radha A., Lee, Andrew W., Stoch, S. Aubrey, and Lai, Eseng
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- *
RESPIRATORY syncytial virus , *MONOCLONAL antibodies , *HUMAN metapneumovirus infection , *CHIMERIC proteins , *RESPIRATORY infections , *PHARMACOKINETICS , *BIOAVAILABILITY - Abstract
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection and related morbidity and mortality in infants. Passive immunization with an RSV‐neutralizing antibody can provide rapid protection to this vulnerable population. Proof‐of‐concept for this approach has been demonstrated by palivizumab; however, the use of this antibody is generally restricted to the highest‐risk infants due to monthly dosing requirements and its cost. To address the large unmet medical need for most infants, we are evaluating MK‐1654, a fully human RSV‐neutralizing antibody with half‐life extending mutations targeting site IV of the fusion protein. In this 2‐part, placebo‐controlled, double‐blind, first‐in‐human study, 152 healthy adults were randomized 3:1 to receive a single dose of MK‐1654 or placebo in 5 cohorts (100 or 300 mg as an intramuscular dose or 300, 1000, or 3000 mg as an intravenous dose). Safety, pharmacokinetics, antidrug antibodies, and RSV serum‐neutralizing antibody titers were evaluated through 1 year. MK‐1654 serum concentrations increased proportionally with dose and resulted in corresponding elevations in RSV serum‐neutralizing antibody titers. The antibody displayed a half‐life of 73 to 88 days and an estimated bioavailability of 69% at the 300‐mg dose. The overall safety profile of MK‐1654 was similar to placebo, and treatment‐emergent antidrug antibodies were low (2.6%) with no associated adverse events. These data support the continued development of MK‐1654 for the prevention of RSV disease in infants. [ABSTRACT FROM AUTHOR]
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- 2021
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37. A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults.
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Aliprantis, Antonios O., Shaw, Christine A., Griffin, Paul, Farinola, Nicholas, Railkar, Radha A., Cao, Xin, Liu, Wen, Sachs, Jeffrey R., Swenson, Christine J., Lee, Heather, Cox, Kara S., Spellman, Daniel S., Winstead, Colleen J., Smolenov, Igor, Lai, Eseng, Zaks, Tal, Espeseth, Amy S., and Panther, Lori
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- 2021
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38. Receptor activator of nuclear factor kappa-B (RANK) independent osteoclast formation and bone erosion in inflammatory arthritis
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O’Brien, William, Fissel, Brian M., Maeda, Yukiko, Yan, Jing, Ge, Xianpeng, Gravallese, Ellen M., Aliprantis, Antonios O., and Charles, Julia F.
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Humans ,Osteoclasts ,Bone Resorption ,Article ,Bone and Bones - Published
- 2016
39. 167 - Policondrite recidivante
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RITTER, SUSAN Y. and ALIPRANTIS, ANTONIOS O.
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- 2016
40. Chapter 2 - The Origins of the Osteoclast
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Aliprantis, Antonios O., Charles, Julia F., and Nakamura, Mary C.
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- 2016
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41. Author Correction: Towards an arthritis flare-responsive drug delivery system
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Joshi, Nitin, primary, Yan, Jing, additional, Levy, Seth, additional, Bhagchandani, Sachin, additional, Slaughter, Kai V., additional, Sherman, Nicholas E., additional, Amirault, Julian, additional, Wang, Yufeng, additional, Riegel, Logan, additional, He, Xueyin, additional, Rui, Tan Shi, additional, Valic, Michael, additional, Vemula, Praveen K., additional, Miranda, Oscar R., additional, Levy, Oren, additional, Gravallese, Ellen M., additional, Aliprantis, Antonios O., additional, Ermann, Joerg, additional, and Karp, Jeffrey M., additional
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- 2018
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42. Towards an arthritis flare-responsive drug delivery system
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Joshi, Nitin, primary, Yan, Jing, additional, Levy, Seth, additional, Bhagchandani, Sachin, additional, Slaughter, Kai V., additional, Sherman, Nicholas E., additional, Amirault, Julian, additional, Wang, Yufeng, additional, Riegel, Logan, additional, He, Xueyin, additional, Rui, Tan Shi, additional, Valic, Michael, additional, Vemula, Praveen K., additional, Miranda, Oscar R., additional, Levy, Oren, additional, Gravallese, Ellen M., additional, Aliprantis, Antonios O., additional, Ermann, Joerg, additional, and Karp, Jeffrey M., additional
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- 2018
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43. Interspecies Comparative Genomics Identifies Optimal Mouse Models of Systemic Sclerosis
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Sargent, Jennifer L., Li, Zhenghui, Aliprantis, Antonios O., Greenblatt, Matthew, Lemaire, Raphael, Wu, Ming-hua, Wei, Jun, Taroni, Jaclyn, Harris, Adam, Long, Kristen B., Burgwin, Chelsea, Artlett, Carol M., Blankenhorn, Elizabeth P., Lafyatis, Robert, Varga, John, Clark, Stephen H., and Whitfield, Michael L.
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Male ,Disease Models, Animal ,Mice ,Scleroderma, Systemic ,Animals ,Humans ,Female ,Article ,Genome-Wide Association Study - Abstract
Understanding the pathogenesis of systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not been delineated. We applied interspecies comparative analysis of genomic data from multiple mouse models of SSc and patients with SSc to determine which animal models best reflect the SSc intrinsic molecular subsets.Gene expression measured in skin from mice with sclerodermatous graft-versus-host disease (GVHD), bleomycin-induced fibrosis, Tsk1/+ or Tsk2/+ mice was mapped to human orthologs and compared to SSc skin biopsy-derived gene expression. Transforming growth factor β (TGFβ) activation was assessed using a responsive signature in mice, and tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) expression was measured in SSc patient and mouse skin.Gene expression in skin from mice with sclerodermatous GVHD and bleomycin-induced fibrosis corresponded to that in SSc patients in the inflammatory molecular subset. In contrast, Tsk2/+ mice showed gene expression corresponding to the fibroproliferative SSc subset. Enrichment of a TGFβ-responsive signature was observed in both Tsk2/+ mice and mice with bleomycin-induced skin fibrosis. Expression of TNFRSF12A (the TWEAK receptor/fibroblast growth factor-inducible 14) was elevated in skin from patients with fibroproliferative SSc and the skin of Tsk2/+ mice.This study reveals similarities in cutaneous gene expression between distinct mouse models of SSc and specific molecular subsets of the disease. Different pathways underlie the intrinsic subsets including TGFβ, interleukin-13 (IL-13), and IL-4. We identify a novel target, Tnfrsf12a, with elevated expression in skin from patients with fibroproliferative SSc and Tsk2/+ mice. These findings will inform mechanistic and translational preclinical studies in SSc.
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- 2016
44. 167 - Relapsing polychondritis
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Ritter, Susan Y. and Aliprantis, Antonios O.
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- 2015
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45. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis
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O'Brien, William, primary, Fissel, Brian M., additional, Maeda, Yukiko, additional, Yan, Jing, additional, Ge, Xianpeng, additional, Gravallese, Ellen M., additional, Aliprantis, Antonios O., additional, and Charles, Julia F., additional
- Published
- 2016
- Full Text
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46. IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease
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Urso, Katia, primary, Alvarez, David, additional, Cremasco, Viviana, additional, Tsang, Kelly, additional, Grauel, Angelo, additional, Lafyatis, Robert, additional, von Andrian, Ulrich H., additional, Ermann, Joerg, additional, and Aliprantis, Antonios O., additional
- Published
- 2016
- Full Text
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47. Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics
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Sargent, Jennifer L., primary, Li, Zhenghui, additional, Aliprantis, Antonios O., additional, Greenblatt, Matthew, additional, Lemaire, Raphael, additional, Wu, Ming-hua, additional, Wei, Jun, additional, Taroni, Jaclyn, additional, Harris, Adam, additional, Long, Kristen B., additional, Burgwin, Chelsea, additional, Artlett, Carol M., additional, Blankenhorn, Elizabeth P., additional, Lafyatis, Robert, additional, Varga, John, additional, Clark, Stephen H., additional, and Whitfield, Michael L., additional
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- 2016
- Full Text
- View/download PDF
48. Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1
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Ge, Xianpeng, primary, Ritter, Susan Y., additional, Tsang, Kelly, additional, Shi, Ruirui, additional, Takei, Kohtaro, additional, and Aliprantis, Antonios O., additional
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- 2016
- Full Text
- View/download PDF
49. Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans
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Urso, Katia, primary, Charles, Julia F., additional, Shull, Gary E., additional, Aliprantis, Antonios O., additional, and Balestrieri, Barbara, additional
- Published
- 2016
- Full Text
- View/download PDF
50. Colony-stimulating factor 1 receptor a (Csf1ra)-deficient zebrafish as a model of unbalanced bone remodeling
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Caetano-Lopes, Joana, primary, Urso, Katia, additional, Henke, Katrin, additional, Aliprantis, Antonios O, additional, Charles, Julia F, additional, Warman, Matthew L, additional, and Harris, Matthew P, additional
- Published
- 2016
- Full Text
- View/download PDF
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