Regina Carvalho Pinto, Alberto Cukier, Celso R. F. Carvalho, Ana Carolina A. C. Pereira, Vinicius Cavalheri, Aline Costa Lopes, Rafaella Fagundes Xavier, Ercy Mara Cipulo Ramos, Universidade de São Paulo (USP), Curtin Univ, Sir Charles Gairdner Hosp, and Universidade Estadual Paulista (Unesp)
Made available in DSpace on 2019-10-04T12:42:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-02-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Introduction People with chronic obstructive pulmonary disease (COPD) present high prevalence of physical inactivity that leads to a negative effect on health-related quality of life (HRQoL). The present study investigated COPD phenotypes according to their levels of physical activity and sedentary behaviour, as well as body composition and skeletal muscle strength. Methods This is an observational and cross-sectional study. Anthropometric data and COPD clinical control were collected and all participants underwent assessments of lung function, HRQoL, dyspnoea, levels of physical activity and sedentary behaviour, body composition and skeletal muscle strength. Participants were classified using hierarchical cluster analysis. Age, dyspnoea and obstruction (ADO) index was used to determine prognosis and calculated for each cluster. Results One hundred and fifty-two participants were included. Three distinct phenotypes were identified. Participants in phenotype 1 were more physically active, less sedentary and had better body composition and lower ADO index (p < 0.0001 for all variables). Overall, participants in phenotypes 2 and 3 were less physically active, more sedentary having a higher ADO index. However, participants in phenotype 2 were older, whereas participants in phenotype 3 had worse HRQoL, clinical control and body composition. Lung function did not differ across the three phenotypes. Conclusions Our results show that physical activity, sedentary behaviour and body composition should be considered to determine phenotypes in people with COPD and are involved in the prognosis of the disease. Less sedentary patients have better prognosis while age, body composition and clinical control seems to differentiate physically inactive patients. Univ Sao Paulo, Sch Med, Dept Phys Therapy, Sao Paulo, Brazil Curtin Univ, Sch Physiotherapy & Exercise Sci, Perth, WA, Australia Sir Charles Gairdner Hosp, Inst Resp Hlth, Nedlands, WA, Australia Univ Sao Paulo, Med Sch, Clin Hosp, Pulm Div,Heart Inst InCor, Sao Paulo, Brazil State Univ Sao Paulo, Dept Phys Therapy, Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Dept Med, Av Dr Arnaldo 455,Room 1210, BR-01246903 Sao Paulo, SP, Brazil State Univ Sao Paulo, Dept Phys Therapy, Sao Paulo, Brazil FAPESP: 2013/20676-9