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2. Bifidobacterium longum Administration Diminishes Parasitemia and Inflammation During Plasmodium berghei Infection in Mice

Author

Fitri, Loeki Enggar, primary, Sardjono, Teguh Wahju, additional, Winaris, Nuning, additional, Pawestri, Aulia Rahmi, additional, Endharti, Agustina Tri, additional, Norahmawati, Eviana, additional, Handayani, Dian, additional, Kurniawan, Shahdevi Nandar, additional, Azizah, Syafiatul, additional, Alifia, Lustyafa Inassani, additional, Asiyah, Rokhmatul, additional, and Ayuningtyas, Tita Rachma, additional

Published
2023
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3. Bifidobacterium longum Administration Diminishes Parasitemia and Inflammation During Plasmodium berghei Infection in Mice

Author

Fitri,Loeki Enggar, Sardjono,Teguh Wahju, Winaris,Nuning, Pawestri,Aulia Rahmi, Endharti,Agustina Tri, Norahmawati,Eviana, Handayani,Dian, Kurniawan,Shahdevi Nandar, Azizah,Syafiatul, Alifia,Lustyafa Inassani, Asiyah,Rokhmatul, Ayuningtyas,Tita Rachma, Fitri,Loeki Enggar, Sardjono,Teguh Wahju, Winaris,Nuning, Pawestri,Aulia Rahmi, Endharti,Agustina Tri, Norahmawati,Eviana, Handayani,Dian, Kurniawan,Shahdevi Nandar, Azizah,Syafiatul, Alifia,Lustyafa Inassani, Asiyah,Rokhmatul, and Ayuningtyas,Tita Rachma

Abstract

Loeki Enggar Fitri,1,2 Teguh Wahju Sardjono,1,2 Nuning Winaris,1,2 Aulia Rahmi Pawestri,1,2 Agustina Tri Endharti,1 Eviana Norahmawati,3 Dian Handayani,4 Shahdevi Nandar Kurniawan,5 Syafiatul Azizah,6 Lustyafa Inassani Alifia,6,7 Rokhmatul Asiyah,6,8 Tita Rachma Ayuningtyas6 1Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 2AIDS, Toxoplasma, Opportunistic Disease, and Malaria (ATOM) Research Group, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 3Department of Anatomical Pathology, Dr. Saiful Anwar Hospital/Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 4Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya, Malang, Indonesia; 5Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 6Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 7Department of Parasitology, Faculty of Medicine, University of Muhammadiyah Malang, Malang, Indonesia; 8State University of Malang, Malang, IndonesiaCorrespondence: Teguh Wahju Sardjono, Department of Parasitology, Faculty of Medicine Universitas Brawijaya, Jl. Veteran, Malang, 65145, Indonesia, Tel +62 341 569117, Fax +62 341 564755, Email teguhws@ub.ac.idPurpose: During Plasmodium berghei (P. berghei) infection, infected erythrocytes are sequestered in gut tissues through microvascular circulation, leading to dysbiosis. This study aimed to investigate the effect of Lactobacillus casei (L. casei) and Bifidobacterium longum (B. longum) administration on the parasitemia level, gut microbiota composition, expression of cluster of differentiation 103 (CD103) in intestinal dendritic and T regulatory cells (T reg), plasma interferon gamma (IFN-γ) and tumor necrosis factor (TNF-α) levels in P. berghei infected mice.Methods: P. berghei was inoculated intraperitoneally. Infected mice were randomly divided into 5 groups and treated with either L. casei, B. longum, or

Published
2023

4. Administration Lactobacillus casei and Bifidobacterium longum improves neurological outcomes in Plasmodium berghei infection.

Author

Pawestri, Aulia Rahmi, Winaris, Nuning, Ayuningtyas, Tita Rachma, Azizah, Syafiatul, Alifia, Lustyafa Inassani, Asiyah, Rokhmatul, Kurniawan, Shahdevi Nandar, Sardjono, Teguh Wahju, and Fitri, Loeki Enggar

Subjects
BIFIDOBACTERIUM longum, PLASMODIUM berghei, CEREBRAL malaria, PLASMODIUM, LACTOBACILLUS casei, GUT microbiome, DIETARY supplements
Abstract

The high mortality and morbidity rates of malaria remains to be a global problem, particularly in tropical regions. Cerebral malaria, the leading cause of death, possesses a complex pathogenesis involving host immune and parasite interactions. Lately, according to the gut-brain axis concept, the gut microbiota was identified to protect the host against systemic pathogen infection through the modulation of immune signaling pathways. In this study, we aimed to explore the effect of probiotic supplementation toward neurological outcomes of cerebral malaria in vivo. Twenty-eight male C57BL/6 mice were randomly divided into 5 groups after 2 weeks acclimatization period. All groups except the negative control were given oral probiotic supplementation with either Lactobacillus casei at 109 colony forming unit/100 µL (CFU/100 µL), Bifidobacterium longum at 109 CFU/100 µL, or the combination of each at 5x108 CFU/100 µL for five days before to six days after Plasmodium berghei infection. Neurological manifestations were recorded by using the SmithKline, Harwell, Imperial College, Royal Hospital, Phenotype Assessment (SHIRPA) score. The data was analyzed by using One-way ANOVA and post-hoc LSD. The results showed that there were significant differences of motor behavior (P < 0.01), muscle tone (P < 0.01), reflex and sensory (P < 0.05), and neuropsychiatric state (P < 0.05) between the control group and that receiving combination of L. casei and B. longum. The results suggested that probiotic supplementation showed promising effects in improving the neurological manifestations during cerebral malaria. Further studies are required to explicate the pathways involved in the immunological interplay. In the future, it is propitious that the mortalities by cerebral malaria could be mitigated through the optimal use of probiotics. [ABSTRACT FROM AUTHOR]

Published
2023

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