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4 results on '"Alice Lund"'

1. Properties and units in the clinical laboratory sciences. Part XXVII: online dynamic NPU manual (IUPAC Technical Report)

Author

Young Bae Lee Hansen, Karin Toska, Alice Lund, Robert Flatman, and Rebecca Ceder

Subjects
General Chemical Engineering, General Chemistry
Abstract

The NPU terminology is an evolving international medical laboratory terminology that is used in health care systems. However, the literature of the terminology is assorted in at least 16 publications that are not updated. The objective is to establish an updated online manual of the NPU terminology, comprising the principles and special rules of the terminology. The manual is intended to provide easily searchable and updated information.

Published
2023
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2. Thermal Fixation of Swine Liver Tissue after Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation1

Author

Erik Fosse, Per Kristian Hol, Peter Jebsen, Per Steinar Halvorsen, Frédéric Courivaud, Aud Svindland, Alice Lund, Airazat M. Kazaryan, Vivian Cecilie Orszagh, Irina Pavlik Marangos, and Bjørn Edwin

Subjects
Hyperthermia, medicine.medical_specialty, Materials science, Acoustics and Ultrasonics, Radiological and Ultrasound Technology, medicine.diagnostic_test, medicine.medical_treatment, Biophysics, Magnetic resonance imaging, Ablation, medicine.disease, High-intensity focused ultrasound, In vivo, Liver tissue, medicine, Radiology, Nuclear Medicine and imaging, Histopathology, Radiology, Fixation (histology), Biomedical engineering
Abstract

The aim of this study was to investigate experimental conditions for efficient and controlled in vivo liver tissue ablation by magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) in a swine model, with the ultimate goal of improving clinical treatment outcome. Histological changes were examined both acutely (four animals) and 1 wk after treatment (five animals). Effects of acoustic power and multiple sonication cycles were investigated. There was good correlation between target size and observed ablation size by thermal dose calculation, post-procedural MR imaging and histopathology, when temperature at the focal point was kept below 90°C. Structural histopathology investigations revealed tissue thermal fixation in ablated regions. In the presence of cavitation, mechanical tissue destruction occurred, resulting in an ablation larger than the target. Complete extra-corporeal MR-guided HIFU ablation in the liver is feasible using high acoustic power. Nearby large vessels were preserved, which makes MR-guided HIFU promising for the ablation of liver tumors adjacent to large veins.

Published
2014
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3. Thermal fixation of swine liver tissue after magnetic resonance-guided high-intensity focused ultrasound ablation

Author

Frédéric, Courivaud, Airazat M, Kazaryan, Alice, Lund, Vivian C, Orszagh, Aud, Svindland, Irina Pavlik, Marangos, Per Steinar, Halvorsen, Peter, Jebsen, Erik, Fosse, Per Kristian, Hol, and Bjørn, Edwin

Subjects
Male, Liver, Swine, Animals, Hepatectomy, High-Intensity Focused Ultrasound Ablation, Magnetic Resonance Imaging, Interventional, Radiation Dosage, High-Energy Shock Waves
Abstract

The aim of this study was to investigate experimental conditions for efficient and controlled in vivo liver tissue ablation by magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) in a swine model, with the ultimate goal of improving clinical treatment outcome. Histological changes were examined both acutely (four animals) and 1 wk after treatment (five animals). Effects of acoustic power and multiple sonication cycles were investigated. There was good correlation between target size and observed ablation size by thermal dose calculation, post-procedural MR imaging and histopathology, when temperature at the focal point was kept below 90°C. Structural histopathology investigations revealed tissue thermal fixation in ablated regions. In the presence of cavitation, mechanical tissue destruction occurred, resulting in an ablation larger than the target. Complete extra-corporeal MR-guided HIFU ablation in the liver is feasible using high acoustic power. Nearby large vessels were preserved, which makes MR-guided HIFU promising for the ablation of liver tumors adjacent to large veins.

Published
2013

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