Search

Abstract The contamination of water by per- and polyfluorinated substances (PFAS) is a pressing global issue due to their harmful effects on health and the environment. This study explores a cationic covalent organic framework (COF), TG-PD COF, for the efficient detection and removal of perfluorooctanoic acid (PFOA) from water. Synthesized via a simple sonochemical method, TG-PD COF shows remarkable selectivity and sensitivity to PFOA, with a detection limit as low as 1.8 µg·L⁻¹. It achieves significant PFOA adsorption exceeding 2600 mg·g⁻¹ within seconds over several cycles in batch mode and complete removal at environmentally relevant concentrations in column adsorption. Results reveal unique adsorption behavior characterized by two phases, leveraging PFOA aggregation through hydrophobic interactions. Computer simulations elucidate the mechanisms underlying TG-PD COF’s sensing, adsorption, and charge transfer dynamics. Our findings position this COF design strategy as a promising solution for combating PFAS contamination in water bodies worldwide.

Despite the metaverse's potential to transform digital business, there remains a scarcity of research investigating on how content marketing affects users' intention to use the metaverse. This study aimed to identify if entertainment content marketing affects users to adapt the metaverse. by adapting the Spice framework, incorporating variables like continuity, sense of presence, interoperability, concurrence, and economic flow. Data was collected via an online survey of 454 online gamers from Jordan who were purposefully selected. Structural equation modelling using partial least squares analysis revealed that all five factors positively affected metaverse intention. Overall, the study contributes to the knowledge by examining the Spice Framework in the context of metaverse technologies. Beyond the academic realm, our findings carry practical significance for marketers, policymakers, and stakeholders shaping the dynamic landscape of digital interactions within the metaverse.

Kajian ini bertujuan untuk mendeskripsikan legislasi adopsi anak dalam hukum Islam dan untuk menunjukkan perbedaan legislasi yang mengatur adopsi anak di Indonesia dan Kazakhtan. Penelitian ini menggunakan strategi dengan metode yuridis yang teratur yang fokus pada penilaian hipotesis, penggalian gagasan, standar dan pedoman yang sah sehubungan dengan peninjauan ini dari bahan-bahan utama. Hasil penelitian ini menunjukkan bahwa mengasuh anak sesuai aturan Islam adalah wajar, namun tidak dipandang sebagai anak kandung pada umumnya. Pengangkatan anak menurut hukum Islamdisebut dengan istilahTabanny. Menurut hukum Islam, pengharaman bagi orang tua yang mengangkat anak namun dititahkan sebagai anak kandung. Regulasilegislasi pengangkatan anak di Indonesia dan Kazakhtan memiliki persamaan yaitu memiliki legislasi yang jelas. Legislasi pengangkatan anak di Indonesia dijelaskan dengan rinci dalam Peraturan Pemerintah Nomor 54 tahun 2007 tentang Pelaksanaan Pengangkatan Anak, sedangkan untuk legislasi yang berlaku di Kazakhtan diatur dalam Pasal 84 sampai Pasal 110 Bab 13 Adopsi Anak Undang-undang Perkawinan dan Keluarga Republik Kazakhtan. Mengenai perbedaan pengangkatan anak antara Indonesia dan Kazakhstan, hukum Indonesia mengatur mengenai kepercayaan antara orang tua angkat dengan calon orang tua angkat, namun hal tersebut tidak dijelaskan di Kazakhstan.Undang-undang di Kazakhstan menjelaskan perbedaan usia minimum antara calon orang tua yang ingin mengadopsi dan calon anak yang ingin mengadopsi, namun peraturan di Indonesia tidak mengaturnya.

The current needs system is no longer determined by real needs but has been regulated with the existence of commodity goods. Society's system of consumption changes rapidly to follow the system of needs so that the consumption of goods and services is no longer a necessity but a desire of every individual who is swept up in the consumptive world. Consumerism culture is considered a culture that must be attached to society in order to obtain an identity. Even though the Prophet Muhammad and his companions, preferred to give infaq fi sabilillah, even well waqf by Utsman Bin Affan, rather than simply consuming a commodity that was not useful and did not spend their wealth on something without benefit, especially for an impossible lifestyle, including using their wealth in moderation. This study uses the literary method to search for various literature sourced from journals and books that have to do with consumerism, consumption, and consumption behavior. The results of the study explain that consumerism which is based on the principles of utilitarianism and rationality alone, encourages consumers to maximize use value without regard to human values and even Islamic values, as a result, creates individualism and self-interest. There are at least 5 points that need to be implemented in Islamic offers in consumption behavior, including 1) Paying attention to priority scales in consuming a commodity, 2) Following Islamic norms in consumption behavior, 3) Maintaining Maqoshid Syariah with the aim of benefiting individuals and society, 4) Comply with the principles of halal and haram, 5) Consumption behavior is part of increasing worship.

Complications associated with Type 1 diabetes (T1D) have complex origins that revolve around chronic hyperglycemia; these complications involve hemostasis disorders, coagulopathies, and vascular damage. Our study aims to develop innovative approaches to minimize these complications and to compare the outcomes of the new approach with those of traditional methods. To achieve our objective, we designed novel nanoparticles comprising covalent organic frameworks (nCOF) loaded with insulin, termed nCOF/Insulin, and compared it to subcutaneous insulin to elucidate the influence of insulin delivery methods on various parameters, including bleeding time, coagulation factors, platelet counts, cortisol plasma levels, lipid profiles, and oxidative stress parameters. Traditional subcutaneous insulin injections exacerbated hemostasis disorder and vascular injuries in streptozotocin (STZ)-induced diabetic rats through increasing plasma triglycerides and lipid peroxidation. Conversely, oral delivery of nCOF/Insulin ameliorated hemostatic disorders and restored the endothelial oxidant/antioxidant balance by reducing lipid peroxidation and enhancing the lipid profile. Our study pioneers the understanding of how STZ-induced diabetes disrupts bleeding time, induces a hypercoagulable state, and causes vascular damage through lipid peroxidation. Additionally, it provides the first evidence for the involvement of subcutaneous insulin treatment in exacerbating vascular and hemostasis disorders in type 1 diabetes (T1D). Introducing an innovative oral insulin delivery via the nCOF approach represents a potential paradigm shift in diabetes management and patient care and promises to improve treatment strategies for type 1 Diabetes.

Recent studies have proved that the utilization of polyethylene (PE) short-section or penstock is a promising water hammer control tool. However, the interplay between the magnitude attenuation and the phase offset of pressure-wave oscillations remains challenging. This study aimed at inspecting the capacity of a dual PE penstock/short-section-based control technique, with regard to the aforementioned interplay. In this technique, a PE penstock was lumped to the transient initiating zone of the main pipe and a short-section of the counter extremity of the pipe was replaced with PE. The transient pressure-wave behavior in a gravitational viscoelastic pipe involving cavitation was described by the extended 1D water hammer equations embedding the Vitkovsky and Kelvin–Voigt add-ons. The numerical solution was performed by the fixed grid method of characteristics. The high- (HDPE) and low-density (LDPE) were demonstrated in this study. Analysis revealed that upgrading techniques based on LDPE enabled a desirable tradeoff between the magnitude attenuation and the phase offset of pressure-wave oscillations. Particularly, the dual penstock/short-section specific upgrading technique allowed a more important attenuation magnitude of pressure peak (or crest), and led to a similar expansion of the wave oscillation period. Furthermore, results evidenced that the proposed technique outperformed the renewal of the original piping system. HIGHLIGHTS A dual polyethylene (PE) penstock upstream and a PE inline short-section downstream are addressed to palliate cavitation.; The rheological mechanical behavior of PE is modeled referring to the generalized linear Kelvin–Voigt approach.; High- and low-density PE are utilized for the short-section or penstock.; The tradeoff between the wave magnitude attenuation and the wave period relaxation is inspected.;

Abstract Controlling the number of molecular switches and their relative positioning within porous materials is critical to their functionality and properties. The proximity of many molecular switches to one another can hinder or completely suppress their response. Herein, a synthetic strategy involving mixed linkers is used to control the distribution of spiropyran-functionalized linkers in a covalent organic framework (COF). The COF contains a spiropyran in each pore which exhibits excellent reversible photoswitching behavior to its merocyanine form in the solid state in response to UV/Vis light. The spiro-COF possesses an urchin-shaped morphology and exhibits a morphological transition to 2D nanosheets and vesicles in solution upon UV light irradiation. The merocyanine-equipped COFs are extremely stable and possess a more ordered structure with enhanced photoluminescence. This approach to modulating structural isomerization in the solid state is used to develop inkless printing media, while the photomediated polarity change is used for water harvesting applications.

Abstract The development of n‐type organic semiconductors has evolved significantly slower in comparison to that of p‐type organic semiconductors mainly due to the lack of electron‐deficient building blocks with stability and processability. However, to realize a variety of organic optoelectronic devices, high‐performance n‐type polymer semiconductors are essential. Herein, conjugated microporous polymers (CMPs) comprising isoindigo acceptor units linked to benzene or pyrene donor units (BI and PI) showing n‐type semiconducting behavior are reported. In addition, considering the challenges of deposition of a continuous and homogeneous thin film of CMPs for accurate Hall measurements, a plasma‐assisted fabrication technique is developed to yield uniform thin films. The fully conjugated 2D networks in PI‐ and BI‐CMP films display high electron mobility of 6.6 and 3.5 cm2 V−1 s−1, respectively. The higher carrier concentration in PI results in high conductivity (5.3 mS cm−1). Both experimental and computational studies are adequately combined to investigate structure–property relations for this intriguing class of materials in the context of organic electronics.

This study aims to examine the influence of brand image as a mediator between social media marketing activity and tourist intentions to visit tourist sites in Jordan. To test the hypotheses, we utilized the partial least square method and distributed a questionnaire survey to 400 visitors, receiving 289 responses for analysis using SMART-PLS4 software. The study made significant contributions to the literature on social media marketing by developing a research model that links social media usage to brand image and shopping intention, and by using statistical techniques to quantitatively assess the effect of social media marketing activity on the brand image as a mediator. The findings exposed that word of mouth, a construct of social media, significantly positively influenced tourists' purchase intention to visit sites in Jordan. This study sheds light on the importance of social media marketing and its impact on the tourism industry in Jordan, providing useful insights for practitioners and policymakers in the field.

This paper aims to optimize a pulsed electrophoretic deposition (EPD) process for TiO2 films. This is accomplished by determining the optimal configuration of the coating parameters from a robust optimization perspective. The experimental study uses a composite central design (CCD) with four control factors, i.e., the initial concentration (x1 in g/L), the deposition time (x2 in s), the duty cycle (x3 in %), and the voltage (x4 in V). The process responses that should all be maximized are the photocatalytic efficiency of the thin film (De) and three critical charges, which characterize the adhesion failure, i.e., LC1: the load at which the first cracks occurred; LC2: the load at which the film starts to delaminate at the edge level of the scratch track; and LC3: the load when the damage of the film exceeds 50%. This paper compares the robust optimization design of the EPD process using two methods: the robust design of processes and products using the stochastic frontier (RDPP-SF) and the surface response and desirability function methods. The findings show that the RDPP-SF method is superior to the response surface–desirability method for the process responses De and LC2 because of non-natural sources of variation; however, both methods perform comparably well while analyzing the LC1 and LC3 responses, which are subjected to pure random variability. The parameters setting for the process robust optimization are met in run 25 (x1 = 14 g/L, x2 = 150 s, x3 = 50%, and x4 40 V).

In this study, we delve into the financial market to compare the performance of prominent AI and robotics-related stocks against traditional IT indices, such as the Nasdaq, and specialized AI and robotics ETFs. We evaluate the role of these stocks in diversifying portfolios, analyzing their return potential and risk profiles. Our analysis includes various investment scenarios, focusing on common AI-related stocks in the United States. We explore the influence of risk management strategies, ranging from “buy and hold” to daily rebalancing, on AI stock portfolios. This involves investigating long-term strategies like buy and hold, as well as short-term approaches, such as daily rebalancing. Our findings, covering the period from 30 April 2021, to 15 September 2023, show that AI-related stocks have not only outperformed in recent years but also highlight the growing “AI bubble” and the increasing significance of AI in investment decisions. The study reveals that these stocks have delivered superior performance, as indicated by metrics like Sharpe and Treynor ratios, providing insights into market trends and financial returns in the technology and robotics sectors. The results are particularly relevant for investors and traders in the AI sector, offering a balanced view of potential returns against the risks in this rapidly evolving market. This paper adds to the financial market literature by demonstrating that investing in emerging trends, such as AI, can be more advantageous in the short term compared to traditional markets like the Nasdaq.

Ionic covalent organic frameworks (iCOFs) are new examples of porous materials and show great potential for various applications. Here, the authors demonstrate functionalization of an iCOFs with suitable emission sites and application as chemosensor for amine detection with high sensitivity which can be used to monitor meat spoilage.

This paper aims to explain dharar as a reason for divorce in the legislation of five Muslim countries, namely Indonesia, Bahrain, Sudan, Qatar, and Morocco. The five countries were chosen with consideration of representing the Sunni Islamic School and one Shia Islamic School. The approach used is a normative approach combined with a comparative method of the law. Primary legal materials are acts and other legislation relevant to the topic of discussion. The results show that the five countries equally provide room for divorce for the wife if she is experiencing dharar, the judge or hakam is obliged to reconcile the two disputing spouses, dharar includes physical and psychological, and the accusation must be proven using evidence generally applicable in procedural law. As for the difference, only Indonesia emphasizes cruelty and physical abuse, while other countries are general. Morocco is the most complete in regulating dharar as a reason for divorce and has several specifics such as violating the marriage agreement which is categorized as dharar. Morocco also regulates compensation due to ḍarar suffered by the wife, while the other four countries do not discuss it in their family law. TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//

The engagement between customers and brands is being transformed by artificial intelligence (AI). However, there has been little study into AI-powered customer experiences; hence, this research aims to examine how the incorporation of AI in purchasing might result in a better AI-powered customer experience. This research will develop a conceptual model based on the service quality model and trust-commitment theory. Further to this, an online questionnaire was distributed to individuals who had utilised an AI-powered service provided by a particular brand, and consequently, a total of 354 responses were analysed using Structural Equation Modelling (SEM). The results that were deduced from the responses demonstrated that relationship commitment has begun to substantially impact AI-powered customer experiences. In addition to this, the results also revealed that perceived sacrifice and trust both play an important role in mediating the impacts of perceived convenience, personalisation, and AI-powered service quality. This finding contributes to the previous literature by highlighting the mediating impacts of perceived sacrifice and trust, as well as the significant influence of relationship commitment on AI-powered customer experience. Furthermore, the research poses significant implications for merchants who use AI in services provided to their customers.

Abstract This paper aims to compare the provisions of fiqh with the legislation in terms of the husband being imprisoned as the reason for the wife to file for divorce in four Muslim countries. They are Indonesia as a representative of the country with the majority of the population following the Shafi'i school, Morocco representing the Maliki school, Jordan representing the Hanafi school, and Qatar representing the Hanbali school. Using a normative approach and a comparative method, this paper aims to look for aspects of similarities as well as differences from fiqh provisions compared to legislation in the four countries. The results shows that the legislation in the four countries basically takes the opinion of the Maliki and Hanbali schools which allow divorce because the husband is imprisoned. From the four countries, Indonesia has set the longest prison term, which is five years, while Morocco and Jordan are imprisoned for a minimum of three years and Qatar is two years. Indonesia and Jordan seem quite far from leaving the rules in the dominant fiqh school in their country by not following the school's fatwa adopted to prohibit divorce because the husband is imprisoned. Meanwhile, Morocco and Qatar are in accordance with the dominant schools of jurisprudence in their countries, with a few additions to more detailed and operational rules. Abstrak Tulisan ini bertujuan membandingkan ketentuan fikih dengan Undang-undang dalam hal suami dipenjara sebagai alasan istri menggugat cerai di empat negara muslim. Mereka adalah Indonesia sebagai representasi negara dengan mayoritas penduduknya menganut mazhab Syafi’i, Maroko mewakili mazhab Maliki, Yordania mewakili mazhab Hanafi, dan Qatar mewakili mazhab Hanbali. Dengan pendekatan normatif dan metode perbandingan, penulis hendak mencari segi-segi persamaan sekaligus perbedaan dari ketentuan fikih dibanding legislasi di empat negara tersebut. Hasilnya adalah legislasi empat negara pada dasarnya mengambil pendapat mazhab Maliki dan Hanbali yang membolehkan cerai gugat karena suami dipenjara. Dari empat negara, Indonesia menetapkan masa penjara terlama yakni lima tahun, sedang Maroko dan Yordania dengan batasan minimal dipenjara selama tiga tahun dan Qatar dua tahun. Indonesia dan Yordania terlihat cukup jauh meninggalkan aturan dalam mazhab fikih yang dominan di negaranya dengan tidak mengikuti fatwa mazhab yang dianut untuk melarang cerai gugat karena suami dipenjara. Sementara Maroko dan Qatar masih selaras dengan mazhab fikih dengan sedikit penambahan aturan yang lebih rinci dan operasional.

The inline or branching water hammer control strategies, which are based on the insertion of compound plastic short-penstock or inline section at the transient-induced region of main pipes, illustrated a promising ability to upgrade steel pipe-based hydraulic systems concerning the extension of admissible pressure level. In this respect, prior results suggested that the specific layout utilizing an (HDPE–LDPE) compound short-penstock (where the (HDPE) sub-short-penstock is attached to the main steel pipe and the (LDPE) sub-short-penstock corresponds to the short-penstock dead-end side) provided significant attenuation of pressure magnitude. Concurrently, recent studies concluded that the (HDPE–LDPE) compound short-section-based inline strategy provided substantial attenuation of pressure magnitude. However, these strategies illustrated a drawback relying on the expansion of the period of pressure wave oscillations. Accordingly, this study assessed and compared the capacities of the compound technique concerning the trade-off between the magnitude-attenuation and the period-expansion of pressure wave oscillations. The findings of these analyses showed that the (HDPE–LDPE) compound short-penstock particular setup of the branching strategy allowed the best trade-off between the attenuation of magnitude and the period expansion of pressure wave oscillations. Furthermore, results showed the competitiveness of the latter upgrading strategy as compared to the (HDPE) or (LDPE) main pipe-based renewed hydraulic systems. HIGHLIGHTS The compound technique-based inline or branching design strategies were investigated.; The HDPE and LDPE plastic materials were investigated.; The (HDPE–LDPE) compound short-penstock-based protected system provided the best trade-off between magnitude and period of pressure wave oscillations.;

Abstract In this paper, a mathematical model for COVID-19 that involves contact tracing is studied. The contact tracing-induced reproduction number R q $\mathcal{R}_{q}$ and equilibrium for the model are determined and stabilities are examined. The global stabilities results are achieved by constructing Lyapunov functions. The contact tracing-induced reproduction number R q $\mathcal{R}_{q}$ is compared with the basic reproduction number R 0 $\mathcal{R}_{0}$ for the model in the absence of any intervention to assess the possible benefits of the contact tracing strategy.

The Calacatta-Carrara marble is widely used due to its excellent physico-chemical characteristics and attractive aspect. However, the sensitivity of this materiel, when performing delicate manufacturing operations, presents for the engineers a hard challenge to overcome. This issue is mainly encountered with complex shapes of parts, for which it is difficult to preserve surface integrity and avoid geometric defects. The paper aims at finding out optimal drilling parameters of cutting in the Calacatta-Carrara white marble material, in order to minimize the holes cylindricity (HC) and surface roughness (HR) using six controlled operating factors, namely, the rotation speed ( N ), the feed speed ( F ), the drill bit diameter (BD), the drill bit height (BH), the number of pecking cycles ( P ), and the drilling depth (DD). The experimental design uses a 2 VI ( 6 − 1 ) fractional factorial plan that is replicated once for cost consideration. The optimization process, that is, minimum cylindricity and roughness tolerances, is carried out using the Gray Relational Analysis (GRA) technique. Numerical modeling of machining parameters is performed using Multi-Layer Perceptron Artificial Neural Network (MLP ANN) and Multiple Regression Model (MR) to predict surface quality. For the sake of completeness these two models were compared in terms of fitness and predictability. The models were assessed statistically using the correlation coefficient. Results showed that either solution predicts a roughness tolerance which is in good agreement with the test data (both R-sq.(adj.) and R-sq.(pred.) >94%). However, the holes cylindricity tolerance response was shown to be superior with MLP-ANN model (R-sq.(adj.) 50.64% and R-sq.(pred.) 48.67%). The GRA analysis shows that minimum cylindricity and roughness are met when N and F are set high, BD and BH low, P high and DD low.

This paper represents a new approach in the exchange rate determination by using microstructural and macroeconomic variables. We test a combination of fundamentals and microstructure variables in cointegrated relationship of the USD/JPY and USD/GBP currencies' pairs. The ‘twofold' model includes interest rate, money supply and net foreign assets as fundamentals, and spread and high-low spread as a microstructure variable. Then we compare the different models of macroeconomic and twofold model with the random walk using an error-correction method. We find that the twofold model outperforms the random structural model in out-of-sample and in-sample forecast test for both exchange rates. Twofold model outperforms in out-of-sample forecast the random walk test for the USD/JPY. Keywords: exchange rate, spreads, interest rate, money supply, net foreign assets, twofold model, cointegration JEL Classifications: G15, G17, G18, F31, F62 DOI: https://doi.org/10.32479/ijefi.11305

Zakah of profession is one source of zakat which began intensively conducted by the government through BAZNAS and Islamic mass organizations in Indonesia recently. Nevertheless, a group of scholars and Islamic mass organizations apparently still has not fully accepted the obligation of this zakah. With other languages,zakah profession still has proponents and opponents. Supporters of zakah of profession consists of MUI, Government, NU, Muhammadiyah, Hidayatullah and others. While that does not agree generally from among those who oriented toward Saudi clerics, Salami, Persis and others. This paper discusses the proposition and the arguments of each group. In the analysis the authors, the arguments for zakat profession more rajah (strong) and assured and more meet maqashid ash-Shariah.

Wave energy is among the many renewable energy technologies being researched and developed to address the increasing demand for low-emissions energy. The unique design challenges for wave energy converter design—integrating complex and uncertain technological, economic, and ecological systems, overcoming the structural challenges of ocean deployment, and dealing with complex system dynamics—have lead to a disjointed progression of research and development. There is no common design practice across the wave energy industry and there is no published synthesis of the practices that are used by developers. In this paper, we summarize the methods being employed in WEC design as well as promising methods that have yet to be applied. We contextualize these methods within an overarching design process. We present results from a survey of WEC developers to identify methods that are common in industry. From the review and survey results, we conclude that the most common methods of WEC design are iterative methods in which design parameters are defined, evaluated, and then changed based on evaluation results. This leaves a significant space for improvement of methods that help designers make better-informed decisions prior to sophisticated evaluation, and methods of using the evaluation results to make better design decisions during iteration. Despite the popularity of optimization methods in academic research, they are less common in industry development. We end this paper with a summary of the areas of WEC design in which the testing and development of new methods is necessary, and where more research is required to fully understand the influence of design decisions on WEC performance.

We study a vector-borne disease with age of vaccination. A nonlinear incidence rate including mass action and saturating incidence as special cases is considered. The global dynamics of the equilibria are investigated and we show that if the basic reproduction number is less than 1, then the disease-free equilibrium is globally asymptotically stable; that is, the disease dies out, while if the basic reproduction number is larger than 1, then the endemic equilibrium is globally asymptotically stable, which means that the disease persists in the population. Using the basic reproduction number, we derive a vaccination coverage rate that is required for disease control and elimination.

Among the problems often experienced by teenagers and youth is a problem of sexual tension that plagues the times before marriage. One of the 'solutions' taken to relieve it This sexual tension is the practice of masturbation or masturbation It is often done especially by teenage boys than girls. Most scholars have declared this activity haram, but some of it exists which punishes conditionally haram, makruh and even some who thinks it's permissible. This article will discuss each each opinion with a comparative perspective of schools of thought for then the assessment is carried out. From the author's assessment, it seems opinions that condemn masturbation are stronger and more realistic for applied.

One of the women issues that has been struggled for by women is equivalence in every sector includes the equivalence in religion sector: prayer. In this case,somewomen—one of them is Amina Wadud—started to introduce and even demonstrated her opinion that women can be theimam of prayers at the open place with various jama’ah from men to women, and it is sah. Although this opinion was not new, because far before that, al-Muzani, Abu Saur and In Jarir at-Tabari had made a fatwato permit that. But the fuqaha tended to forbid and oppose it. This article tried to describe that khilafiyah, complete with the ulama and the arguments as the bases.

City of Surakarta, known as Solo City is one of cities in Central Java Province traversed by Bengawan Solo River. Heavy rainfall in upstream area of Bengawan Solo River causes increase in high water level at downstream. Bengawan Solo River will be higher than water level in drainage system which may induce a backwater flow. Since Colonization era, the government has built dikes and barrages against backwater flow and inundation problem. One of the barrages was Demangan Barrage dividing river flow into Bengawan Solo River and Pepe River. It was equipped with total capacity pump of 12,3 m3/s. The inundation is not only caused by the backwater flow coming from Bengawan Solo River, but also surface runoff as the result of the excess rainfall which cannot be drained gravitationally to the main river if the gate was closed. Therefore, comprehensive study combining hydrology and hydraulics analysis is highly needed in order to achieve more effective flood control management. Hydrology analysis was done to estimate the direct runoff hydrograph from catchment area in Solo City to downstream of Pepe River. While in hydraulics case, hydraulic parameter in downstream of Pepe River influenced by Bengawan Solo River stream was analyzed. Both studies were simulated using software HEC-RAS 4.1.0 version. The simulation considered drainage channel, gate, pump system and dike in Pepe River downstream. Simulation using 10 years of return period in Solo City and average annual water level in Bengawan Solo River showed that Pepe River can flow through the gate, while the highest water level is still below the dike. Simulation considering 10 years of return period, water level hydrograph of Bengawan Solo River, existing pump, and gate operation inferred that Pepe River surpassed top of dike. Capacity of required pump should be more than 168,3 m3/s in order to pass 10 years of return period. By combining operational of existing pump and dike elevated up to +87,63 m, capacity of required pump became lesser which was approximately 120,3 m3/s. Simulation of HEC-RAS conducted by operating pump automatically on critical elevation without heightened dike obtained the total capacity of pump was 132,3 m3/s. Keywords: barrage, pump operation, Bengawan Solo River, flood control management.

The purpose of the present study was to early detection and management of retinopathy of prematurity (ROP). This observational descriptive/ interventional study was carried out to evaluate 96 babies brought by their parents to BIRDEM General Hospital during the period of January 2016 to June 2016 who fulfilled the inclusion and exclusion criteria. Screening of ROP was performed in all 96 babies after taking informed written consent. After screening of ROP, the babies who had ROP, staging was done and treatment was given as per requirement. Descriptive data in the study were shown by cross table and compared by student paired 't' test and Chi-square test. The study included total 96 babies of preterm low birth weight. Among them 64(66.66%) babies had no ROP, where 32(33.33%) babies had different stages of ROP. In these 32 babies, 18 babies didn't need any treatment, only 14 babies needed treatment according to their requirement (14 babies had 28 eyes, where 16 eyes needed Inj. Anti VEGF and laser and 11 eyes needed only laser and one eye had Stage V ROP, so observed that eye). Early detection of ROP and proper management not only restore the anatomical and functional outcome of the retina, but also restore the vision, prevent childhood blindness and decrease morbidity.

Purpose: To describe the vitreomacular interface and foveal structural changes in fellow eyes of patients with idiopathic macular holes using spectral-domain optical coherence tomography (SD-OCT)., Methods: Retrospective analysis of consecutive medical records and SD-OCT images of the fellow eyes of patients with macular hole was done. Changes of the vitreoretinal interface and foveal structures on SD-OCT scan of the 101 fellow eyes of 101 subjects with full-thickness macular hole were studied and compared with 101 eyes of 101 age-matched healthy subjects., Results: Sixty-four patients (57.65%) were female. Mean age at presentation was 60.44 ± 12.17 years. The best-corrected visual acuity (BCVA) in eyes with macular hole was 0.86 logMAR units and in fellow eyes was 0.41 logMAR units. Seven eyes had macular hole in the fellow eye at the time of presentation. The majority of the fellow eyes (87/101, 78.37%) were phakic. The average base diameter of macular hole was 1105 ± 451.63 µm. Incidence of vitreomacular traction, epiretinal membrane, lamellar hole, and inner foveal split was more common (<0.05) in fellow eyes in comparison to healthy eyes. In contrast, posterior vitreous detachment (PVD) and perifoveal PVD was more common in age-matched control eyes. There was no statistically significant correlation between foveal abnormalities of fellow eyes with base diameter of eyes with macular hole, BCVA, and duration of symptoms., Conclusions: Fellow eyes of patients with idiopathic macular hole have a high frequency of abnormal vitreoretinal interface and foveal abnormalities, which predisposes to formation of macular hole.

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5β1- and αvβ3-integrins. Cells adherent via α5β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins., (© 2013 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Selective and targeted delivery of drugs to tumors is a major challenge for an effective cancer therapy and also to overcome the side-effects associated with current treatments. Overexpression of various receptors on tumor cells is a characteristic structural and biochemical aspect of tumors and distinguishes them from physiologically normal cells. This abnormal feature is therefore suitable for selectively directing anticancer molecules to tumors by using ligands that can preferentially recognize such receptors. Several subtypes of integrin receptors that are crucial for cell adhesion, cell signaling, cell viability, and motility have been shown to have an upregulated expression on cancer cells. Thus, ligands that recognize specific integrin subtypes represent excellent candidates to be conjugated to drugs or drug carrier systems and be targeted to tumors. In this regard, integrins recognizing the RGD cell adhesive sequence have been extensively targeted for tumor-specific drug delivery. Here we review key recent examples on the presentation of RGD-based integrin ligands by means of distinct drug-delivery systems, and discuss the prospects of such therapies to specifically target tumor cells.

Natural competence for DNA uptake is common among bacteria but its evolutionary function is controversial. Resolving the dispute requires a detailed understanding of both how cells decide to take up DNA and how the DNA is processed during and after uptake. We have used whole-genome microarrays to follow changes in gene expression during competence development in wild-type Haemophilus influenzae cells, and to characterize dependence of competence-induced transcription on known regulatory factors. This analysis confirmed the existence of a postulated competence regulon, characterized by a promoter-associated 22 bp competence regulatory element (CRE) closely related to the cAMP receptor protein (CRP) binding consensus. This CRE regulon contains 25 genes in 13 transcription units, only about half of which have been previously associated with competence. The new CRE genes encode a periplasmic ATP-dependent DNA ligase, homologs of SSB, RadC and the Bacillus subtilis DNA uptake protein ComEA, and eight genes of unknown function. Competence-induced transcription of genes in the CRE regulon is strongly dependent on cAMP, consistent with the known role of catabolite regulation in competence. Electrophoretic mobility-shift assays confirmed that CRE sequences are a new class of CRP-binding site. The essential competence gene sxy is induced early in competence development and is required for competence-induced transcription of CRE-regulon genes but not other CRP-regulated genes, suggesting that Sxy may act as an accessory factor directing CRP to CRE sites. Natural selection has united these 25 genes under a common regulatory mechanism. Elucidating this mechanism, and the functions of the genes, will provide a valuable window into the evolutionary function of natural competence.

In 1995 the genome sequence of the Haemophilus influenzae KW20 (Rd) strain was published, the first available for a free-living organism. The genome has been invaluable in global strategies to identify certain virulence-related genes, e.g. those involved in LPS synthesis, and also essential genes, but there is a paucity of wholegenome transcriptome studies. We have now constructed a whole-genome array consisting of genes from Rd, additional genes identified in other strains of H. influenzae and controls (from eukaryotic sources and other bacteria). We intend to use this array in studies aimed at understanding the bacterium's basic metabolism and its response to changing environments; deciphering global regulatory networks (by comparison of wild-type and mutant strains); and identifying genes expressed in vivo. The use of H. influenzae DNA arrays combined with proteomic approaches will enhance our understanding of the metabolism and virulence of the organism. Additionally, the genome sequence of a non-typable H. influenzae strain is in progress. The sequence from this isolate will be invaluable not only in identifying potential novel antibiotic targets and putative vaccine candidates but also in the design of a microarray for genome-typing purposes.