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1. The role of helminths and their antigens in cancer therapy: insights from cell line models

Author: Gita Alizadeh, Ali Kheirandish, Maryam Alipour, Mahnaz Jafari, Mahdis Radfar, Tina Bybordi, and Raheleh Rafiei-Sefiddashti
Subjects: Cancer, Antigen, Treatment, Helminths, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background Recent articles have explored the effect of worms on cancer cells. This review focused on various cell cultures employed to understand which cells are more commonly and less utilized. Methods The present review analyzed studies published between 2013 and 2023 to obtain information about different cell cultures used in cancer studies involving helminths. Databases such as PubMed, Google Scholar, HINARI, and the Cochrane Library were searched. Results This search yielded 130 records, but 97 papers were excluded because they were either irrelevant to the research topic (n = 72) or contradicted the research idea (n = 25).The remaining twenty-one articles focused on different types of worms, such as Echinococcus granulosus, Clonorchis sinensis, Opisthorchis felineus, Opisthorchis viverrini, Trichinella spiralis, Toxocara canis, and Heligmosomoides polygyrus. Conclusion Due to the presence of numerous antigens, parasites at different growth stages can impact various cells through unknown mechanisms. Given the high diversity of antigens and their effects, artificial intelligence can assist in predicting initial outcomes for future studies.
Published: 2024
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2. Flavonoids against depression: a comprehensive review of literature

Author: Alaleh Alizadeh, Yeganeh Pourfallah-Taft, Maryam Khoshnazar, Aysan Safdari, Saba Vafadar Komari, Mehrnaz Zanganeh, Nafiseh Sami, Maryam Valizadeh, Arezoo Faridzadeh, Dorsa Alijanzadeh, Seyed Amirhossein Mazhari, Reza Khademi, Ali Kheirandish, and Mahdyieh Naziri
Subjects: tehran hemat highway next to milad Tower14535, Iran antidepressant, flavonoids, natural products, herbal medicine, complementary medicineIntroduction, Therapeutics. Pharmacology, RM1-950
Abstract: BackgroundDepression is a state of low mood and aversion to activity, which affects a person’s thoughts, behavior, motivation, feelings, and sense of wellbeing. Pharmacologic therapies are still the best effective treatment of depression. Still, most antidepressant drugs have low efficacy and delayed onset of therapeutic action, have different side effects, and even exacerbate depression. Such conditions make it possible to look for alternatives. Consequently, we decided to summarize the impact of flavonoids on depression in this review.MethodsWe searched scientific databases such as SCOPUS, PubMed, and Google Scholar to find relevant studies until July 2022.ResultsA wide variety of natural components have been shown to alleviate depression, one of which is flavonoids. Due to the growing tendency to use natural antidepressant drugs, scientific studies are increasingly being conducted on flavonoids. This study aims to review the latest scientific researches that indicate the antidepressant potential of flavonoids. Various mechanisms include neurotransmitter system modulation and dopaminergic, noradrenergic, and serotonergic pathways regulation in the central nervous system. Different compounds of flavonoids have antidepressant properties in vivo or in vitro experiments or clinical trials and can be used as alternative and complementary treatments for depression. In general, it was observed that there were no severe side effects.ConclusionOur study proves the antidepressant potential of flavonoids, and considering the limited side effects, they can be used as complementary medicine for depressed patients.
Published: 2024
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3. Health Literacy Among University Students in the COVID-19 Pandemic: A Systematic Review

Author: Mohammadreza Arzaghi, Neda Tizro, Parna Ghannadikhosh, Parisa Alsadat Dadkhah, Razieh Mohammadi-Dashtaki, Saleh Behzadi, Fereshteh Sohrabivafa, Kiana Naghavi, Ali Sanaye Abbasi, Ali Darroudi, Mohammad Abbasalizadeh, Ali kheirandish, Mohadeseh Poudineh, Niloofar Deravi, Fateme Sedghi, and Hamed Fakhrabadi
Subjects: covid-19, pandemics, health literacy, sars-cov-2, Internal medicine, RC31-1245
Abstract: Background: The purpose of this systematic review was to assess different studies that worked on university students’ health literacy during covid19 pandemic and to make an overview of this issue to recognize possible determinants associated with health literacy. Methods: This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). Four databases (Google Scholar, Web of Science, Pubmed, and Scopus) were used for searching cross-sectional works that assessed the health literacy of university students. We searched papers from December 1st, 2019 up to June 10th, 2022. English language articles were used. Studies were done in countries including; Iran, Pakistan, the USA, Vietnam, China, Colombia, Germany, and Indonesia. Results: The systematic review contains 12 research studies involving 17773 students. There was a relationship between health literacy and some determinants. Positive determinants included age, female gender, Urban background, cognitive maturity, Higher educational qualification, information source (Health workers), number of semesters, and parental education. Some negative determinants were male gender, Rural background, smoking, drinking, being able to pay for medication, lower conspiracy beliefs, and higher fear of COVID-19. Conclusion: University students around the world should have courses about health literacy according to university disciplines. These courses should be available for students of different fields to enhance their effectiveness, and training should be associated with students’ needs and their subgroup traits.
Published: 2024

4. Azithromycin for COVID-19: Pharmacological Mechanisms, Challenges, and Prospects

Author: Parisa Saberi-Hasanabadi, Milad Esmaeilzadeh Farmad, Sajad Aboulfazli, Ali Kheirandish, Amin Ataie, Somayyeh Boshtam, and Ramin Ataee
Subjects: Azithromycin, COVID-19, Clinical trial, Antiviral and immunomodulatory agents, Cytokine release syndrome, Medicine (General), R5-920
Abstract: The coronavirus disease (COVID)-19 pandemic led to a new challenge in the field of effective treatment methods for this disease. Antiviral and immunomodulatory agents were suggested as potential therapeutic methods in this field. Since the most severe clinical symptoms associated with COVID-19 disease appear to be acute respiratory syndrome, azithromycin has been proposed as a potentially effective drug in this context. We have updated the evidence and selected all relevant items to understand the mechanism of role of azithromycin, clinical efficacy, and their side effects in coronavirus disease-19 treatment on July 20th and updated on March 20th, 2020. A literature search of electronic databases including the Web of Science, PubMed, and Google Scholar was conducted by searching keywords such as "Azithromycin", "COVID-19", and "Combination therapy". The ultimate goal of this review was identifying eligible studies about the pharmacological activities, safety, and effectiveness of azithromycin in treating COVID-19 patients. Immunomodulatory properties of azithromycin include the ability to reduce cytokine production, maintain epithelial cell integrity, or prevent lung fibrosis. The use of azithromycin in some studies was associated with a decrease in mortality and need for ventilation in patients. These properties can be useful during the period of COVID-19 infection, especially in patients with underlying diseases. However, the evidence for the use of azithromycin is still scarce and the quality of the studies is low. In some retrospective studies, azithromycin was mainly evaluated in combination with hydroxychloroquine, which showed no particular advantage. The results of this review showed that azithromycin has appropriate and well-known safety characteristics in the treatment of patients with COVID-19. However, the most appropriate dosage in different stages of the disease and the effect of its combination with other drugs are important questions that should be considered in future clinical trials.
Published: 2023
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5. The effect of gabapentin and pregabalin administration on memory in clinical and preclinical studies: a meta-analysis and systematic review

Author: Zahra Behroozi, Maral Jafarpour, Maryam Razmgir, Sepideh Saffarpour, Hanieh Azizi, Ali Kheirandish, Tahereh Kosari-rad, Fatemeh Ramezni, and Atousa Janzadeh
Subjects: Gabapentin, Pregabalin, Memory, Pain, Psychiatry, RC435-571
Abstract: Abstract Background Today, gabapentinoids such as Gabapentin (GBP) and pregabalin (PGB) are widely used as painkillers. This may alter the function of the nervous system; hence their results may include a difference in memory and processes that end in memory formation. This study aims to conclude whether gabapentinoids can alter memory or not by reviewing and analyzing clinical and preclinical studies. Material and methods A comprehensive search was carried out in databases including PUBMED, EMBASE, SCOPUS, and Web of Science. In the included studies, memory was measured as an outcome variable in clinical or preclinical studies. Result A total of 21 articles (4 clinical, 17 preclinical) were included in the meta-analysis by STATA Software. The results showed that memory changes under the influence of GBP. Both the administrated dosage and the time of administration are important in the final results and latency time of retention. GBP administration in healthy animals increased latency time, whereas if the administration of GBP took place exactly before training, the latency time increased slightly. Short-term administration of PGB in healthy volunteers is accompanied by transient side effects on the CNS. However, the number and homogeneity of the studies were not such that a meta-analysis could be performed on them. Conclusion Clinical and preclinical studies showed that PGB administration did not confirm its improving memory effect. GBP administration in healthy animals increased latency time and improved memory. Although it depended on the time of administration.
Published: 2023
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6. Comparison of Self and Peer Assessment on the Clinical Competence of Medical Students of Jahrom University of Medical Sciences

Author: Sedigheh Najafipour, Abazar Roustazadeh, Rahim Raoofi, Tahere Rahimi, Fateme Najafipour, Esmaeel Rayeatdost, Marziye Haghbin, Ali Dehghani, Majid Kowsari, Ali Kheirandish, and Atefe Karamzade Jahromi
Subjects: self-assessment, peer assessment, medical student, clinical competency, Education (General), L7-991, Medicine (General), R5-920
Abstract: Introduction: Assessing students' professional skills, teamwork and communication proficiency in the clinical environment by multiple evaluators such as educators, peers and students themselves is essential. The aim of this study was to compare the self-assessment method and peer assessment as means of evaluation on the clinical competence of medical students of Jahrom University of Medical Sciences. Methods: This cross-sectional study was performed on 110 medical students of University of Medical Sciences in 2020-2021.Convenience sampling method was used. To assess clinical competence, a valid and reliable questionnaire was used in four areas of communicative proficiency, cooperation with the medical team, patient management and practical skills. Data analysis was performed using independent t-test and one-way analysis of variance. Result: The results of self-assessment showed that students in the field of practical skills (12.44 ± 3.16) were more capable but in the field of communication skills (7.96 ± 2.01) scored low on their ability. Peer assessment, the highest score was seen in the field of practical skills (12.69 ± 2.44) and the least was allocated to the field of cooperation with the treatment team (7.70 ± 1.96.). Comparing the mean scores of self-assessments with the mean scores of peers demonstrated a statistically significant difference (P < 0.001). Conclusion: Self-assessment and peer assessment as a complementary, applicable and accessible method for assessing students' achievement of expected competencies can be considered in the evaluation system of clinical education.
Published: 2022

7. Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?

Author: Kimia Keylani, Fariba Arbab Mojeni, Amirmohammad Khalaji, Asma Rasouli, Dlnya Aminzade, Mohammad Amin Karimi, Pantea Majma Sanaye, Nazanin Khajevand, Nasrin Nemayandeh, Mohadeseh Poudineh, Mehdi Azizabadi Farahani, Mohammad Ali Esfandiari, Sepehr Haghshoar, Ali Kheirandish, Erfan Amouei, Amir Abdi, Arash Azizinezhad, Afshin Khani, and Niloofar Deravi
Subjects: endoplasmic reticulum stress, flavonoids, quercetin, kaempferol, cardiovascular diseases, Therapeutics. Pharmacology, RM1-950
Abstract: Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses. The most flavonoid’s critical subclasses with improved health properties are the catechins or flavonols (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavanones (e.g., naringenin from citrus), the flavanols (e.g., quercetin glycosides from berries, onion, and apples), the isoflavones (e.g., genistein from soya beans) and the anthocyanins (e.g., cyanidin-3-O-glucoside from berries). Scientific data conclusively demonstrates that frequent intake of efficient amounts of dietary flavonoids decreases chronic inflammation and the chance of oxidative stress expressing the pathogenesis of human diseases like cardiovascular diseases (CVDs). The endoplasmic reticulum (ER) is a critical organelle that plays a role in protein folding, post-transcriptional conversion, and transportation, which plays a critical part in maintaining cell homeostasis. Various stimuli can lead to the creation of unfolded or misfolded proteins in the endoplasmic reticulum and then arise in endoplasmic reticulum stress. Constant endoplasmic reticulum stress triggers unfolded protein response (UPR), which ultimately causes apoptosis. Research has shown that endoplasmic reticulum stress plays a critical part in the pathogenesis of several cardiovascular diseases, including diabetic cardiomyopathy, ischemic heart disease, heart failure, aortic aneurysm, and hypertension. Endoplasmic reticulum stress could be one of the crucial points in treating multiple cardiovascular diseases. In this review, we summarized findings on flavonoids’ effects on the endoplasmic reticulum and their role in the prevention and treatment of cardiovascular diseases.
Published: 2023
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8. Antiviral Potential of Melissa officinalis L.: A Literature Review

Author: Amirhossein Behzadi, Sadegh imani, Niloofar Deravi, Zahra Mohammad Taheri, fatemeh mohammadian, zahra moraveji, Sepideh Shavysi, Motahareh Mostafaloo, Fateme Soleimani Hadidi, Sepehr Nanbakhsh, Sepehr Olangian-Tehrani, Mohammad Hesam Marabi, Parisa behshood, Mohadeseh Poudineh, Ali Kheirandish, Kimia Keylani, and Pooya Behfarnia
Subjects: Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract: The use of synthetic drugs has increased in recent years; however, herbal medicine is yet more trusted among a huge population worldwide; This could be due to minimal side effects, affordable prices, and traditional beliefs. Lemongrass ( Melissa officinalis ) has been widely used for reducing stress and anxiety, increasing appetite and sleep, reducing pain, healing wounds, and treating poisonous insect bites and bee stings for a long time. Today, research has shown that this plant can also fight viruses including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV) through various mechanisms such as inhibiting HSV-1 from binding to host cell, inhibiting HSV-1 replication during the post-adsorption or inhibiting main protease and spike protein of SARS-CoV-2, furthermore, be effective in treating related diseases. This Review investigated the antiviral properties of Melissa officinalis and its effect on viral diseases. More in vitro and in vivo studies are needed to determine Melissa officinaliss underlying mechanism, and more randomized controlled trials should be done to identify its effect in humans. Also, due to the usefulness and lack of side effects, it can be used more as a complementary medicine.
Published: 2023
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9. Detecting High-energy Neutrino Minibursts from Local Supernovae with Multiple Neutrino Observatories

Author: Ali Kheirandish and Kohta Murase
Subjects: Supernova neutrinos, Particle astrophysics, High energy astrophysics, Neutrino astronomy, Neutrino telescopes, Astrophysics, QB460-466
Abstract: Growing evidence from multiwavelength observations of extragalactic supernovae (SNe) has established the presence of dense circumstellar material in Type II SNe. Interaction between the SN ejecta and the circumstellar material should lead to diffusive shock acceleration of cosmic rays and associated high-energy emission. Observation of high-energy neutrinos along with the MeV neutrinos from SNe will provide unprecedented opportunities to understand unanswered questions in cosmic-ray and neutrino physics. We show that current and future neutrino detectors can identify high-energy neutrinos from an extragalactic SN in the neighborhood of the Milky Way. We present the prospects for detecting high-energy neutrino minibursts from SNe in known local galaxies, and demonstrate how the network of multiple high-energy neutrino detectors will extend the horizon for the identification of high-energy SN neutrinos. We also discuss high-energy neutrino emission from SN 2023ixf.
Published: 2023
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10. Methylation Assessment of Two DKK2 and DKK4 Genes in Oral Squamous Cell Carcinoma Patients

Author: Sedigheh KHEIRANDISH, Nosratollah ESHGHYAR, Farzad YAZDANI, Pouyan AMINI SHAKIB, Ali HOSSEINI-BERESHNEH, Zahra NOURI, Ali KHEIRANDISH, and Fatemeh KARAMI
Subjects: Methylation, Oral squamous cell carcinoma, Methylation-specific polymerase chain reaction, Public aspects of medicine, RA1-1270
Abstract: Background: Oral squamous cell carcinoma (OSCC) is one of the most important types of oral malignancies. DKK gene family members as well as DKK2/4 have critical roles in regulation of Wnt signaling as one of the main determining pathway in oral carcinogenesis. This study aimed to identify promoter methylation status of DKK2/4 genes to provide possible biomarkers for early detection and treatment of OSCC patients. Methods: A case control study was performed on 31 fresh tissues obtained from oral cavity of patients affected by OSCC and 31 fresh corresponding tissues from normal healthy controls in Tehran and, between the years of 2016-2018. Purified DNA from tissue samples was subjected to bisulfite treatment and then methylation specific polymerase chain reaction (MSP-PCR) was carried out on treated DNA samples. Results: DKK4 promoter was methylated in none of OSCC samples while it was methylated in 16.1% of healthy controls. 16.1% of OSCC samples were detected to be semimethylated and 22.6% of healthy normal samples were methylated for DKK2 promoter gene. Meaningful difference was found in DKK4 promoter methylation among OSCC patients and healthy controls. Significant correlation was found between DKK4 promoter methylation and tumor grade. The age of all enrolled samples was demonstrated to have strong effect on promoter methylation of studied genes. Conclusion: Hypomethylation of DKK2 and DKK4 genes in higher grades of OSCC samples may indicate the pivotal role of their expression in tumor cells invasion and progression through modulation of Wnt signaling pathway. Further study required to determine simultaneous expression of those genes and Wnt signaling elements at mRNA and protein levels.
Published: 2020
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11. Multimessenger Search for the Sources of Cosmic Rays Using Cosmic Neutrinos

Author: Francis Halzen and Ali Kheirandish
Subjects: multimessenger, neutrinos, cosmic rays, blazars, cosmic accelerators, Astronomy, QB1-991, Geophysics. Cosmic physics, QC801-809
Abstract: After updating the status of the measurements of the cosmic neutrino flux by the IceCube experiment, we summarize the evidence for the first identified source of cosmic rays and speculate on the connection between the two observations.
Published: 2019
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12. Neutrinos from the Brightest Gamma-Ray Burst?

Author: Kohta Murase, Mainak Mukhopadhyay, Ali Kheirandish, Shigeo S. Kimura, and Ke Fang
Published: 2022
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13. Evaluation of curcumin effect on Il6, Sirt1, TNFα and NFkB expression of liver tissues in diabetic mice with STZ

Author: Somayyeh Mojtabavi, Amin Saed, Sajad Aboulfazli, Ali Kheirandish, Mojtaba Najafi, Majid Jafari-Sabet, Ali Ziar, Nima Ebrahimi, Seyedeh Habibeh Mirmajidi, and Ramin Ataee
Subjects: Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 2022
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14. Polymorphism of LRP4 Gene (rs9667108) among Post Menopause Women with Osteoporosis

Author: Saeid Kavoosian, Alimohammad Asgharian, Mohsen Asouri, Sadegh Fattahi, Galia Amirbozorgi, Ali Kheirandish, Sajad Abolfazli, Maryam Lotfi, Nima Ebrahimi, and Ramin Ataee
Subjects: Public Health, Environmental and Occupational Health
Abstract: Background: Many studies have been done to identify the factors that influence the development and progression of osteoporosis. One genetic factor is polymorphisms of LRP4 gene. Regarding the lack of comprehensive study on polymorphisms of LRP4 gene in the north of Iran, mainly Mazandaran Province, we decided to investigate the polymorphism of this gene in postmenopausal women with osteoporosis. Methods: This case-control study has been conducted at GhaemShahr Valiasr Hospital on 100 female patients with osteoporosis (average age of 58.1) and 90 healthy females without osteoporosis (average age of 55.2). After sampling and extraction of genomic DNA via of the salt deposition method, the genotype and SNP (rs9667108) polymorphism of LRP4 gene were evaluated with the PCR-RFLP method. Restriction enzymes cut the PCR products. In order to identify patients, their bone mineral density was tested by the DEXA method .The results of digestion (digestion enzyme) were analyzed by MedCalc, SPSS software, Hardy-Weinberg equilibrium, and Chi2. Results: The statistical analysis has shown the significant relationship between SNP (rs9667108) polymorphism and the risk of osteoporosis disease in patients and control groups (P
Published: 2023
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15. The impact of malignancy on the risk of venous thromboembolism in pregnant women: a systematic review

Author: Ali Vaezi, Seyyed Kiarash Sadat Rafiei, Bita Amiri, Ali Rezvanimehr, Maryam Najiabhary, Pariya Mahdavi, Mohammad Abbasalizadeh, Ghazale Yavari, Mahsa Shirforoush Sattari, Ali Kheirandish, Gisou Erabi, Foad Vakili Zadeh, Fateme Rasekh, Asiyeh Pormehr-yabandeh, Seyede Zohreh Mohagheghi, Ramin Ahangar-Sirous, Amir Abdi, Parisa alsadat Dadkhah, and Niloofar Deravi
Abstract: Background and aims: Venous thromboembolism (VTE) is a common complication of malignancy associated with a three-fold increase risk of death. Pregnancy is also a recognized risk factor for VTE, and is associated with a 4-5 fold increase risk compared to non-pregnant women. Considering that any review article has not been published in this field yet and given that complications of VTE can be reduced by early identifying between pregnant women the current systematic review aimed to elucidate the impact of malignancy on the risk of VTE in pregnant females. Methods: We carried out a systematic search in multiple databases, including PubMed (Medline), Google Scholar, and Scopus up to January 2023. Finally, 441 related articles were extracted from the databases, after screening the title, abstract and full text, seven articles were included in the study. Results: Seven studies (6 cohorts and 1 cross-sectional) with an entire of 58,854,195 pregnant females (22,396 cancer patients) were included. These studies were done in the United States of America, Canada, Brazil, and Denmark. All of the studies except one study demonstrated that cancer in pregnant patients increased the risk of deep vein thrombosis (DVT). The VTE prevalence was significantly higher in cancer groups compared with the non-cancer group and the highest (adjusted odds ratio) aOR was correlated to myeloid leukemia. Conclusions: Pregnant women with malignancy are more susceptible to VTE and other coagulation disorders. Physicians and health policymakers should be of high vigilance to pregnancy-associated VTE, especially in women suffering from cancer.
Published: 2023
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16. Dark Matter decay to neutrinos

Author: Diyaselis Delgado, Carlos Arguelles, Avi Friedlander, Ali Kheirandish, Ibrahim Safa, Aaron Vincent, and Henry White
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract: It is possible that the strongest interactions between dark matter and the Standard Model occur via the neutrino sector. Unlike gamma rays and charged particles, neutrinos provide a unique avenue to probe for astrophysical sources of dark matter, since they arrive unimpeded and undeflected from their sources. Previously, we reported on annihilations of dark matter to neutrinos; here, we review constraints on the decay of dark matter into neutrinos over a range of dark matter masses from MeV to ZeV, compiling previously reported limits, exploring new electroweak corrections and computing constraints where none have been computed before. We examine the expected contributions to the neutrino flux at current and upcoming neutrino experiments as well as photons from electroweak emission expected at gamma-ray telescopes, leading to constraints on the dark matter decay lifetime, which ranges from $\tau \sim 1.2\times10^{21}$ s at 10 MeV to $1.5\times10^{29}$s at 1 PeV., Comment: 11 pages, 5 figures. Introductory video of this article can be found in https://youtu.be/q5jO7sCQl8c
Published: 2022

17. Prevalence of Adverse Transfusion Reactions in Hospitalized Patients in Tertiary Heart Center of Sari, Iran in 2014-2020

Author: Mehdi Bahrami, Farzane Felehkari, Mahdie Darvish-Khezri, Ali Kheirandish, Aghil Mollaie, Mohammad Ahmadi, Zahra Faghihian, Hanie Mostafavi, Pardis Karimnezhad, Nima Ahmadi Nik Jouneghani, and Soheil Azizi
Abstract: Introduction: Our study aimed to determine the prevalence of adverse transfusion reactions (ATRs), unexpected or undesirable effects resulting from the therapeutic use of blood products. Material and Methods: In this cross-sectional study, we assessed the medical records of ATR patients who were referred to Mazandaran Heart Center from March 2014 until July 2020. Patients needed blood transfusions during the operation for various reasons; complications related to blood administration were considered ATR. Age, sex, associated clinical signs, symptoms, and adverse response were composed of a patient's file checklist with ethical points. SPSS 16.0 was used for statistical analysis. Results: In this study, 23,206 blood products were used in hospitals as treatment, and there were 96 reactions (4%) because of transfusion, and 10 patients had a history of recent reactions. There was not any specific connection between the age of patients and the existence of complications. Most reactions were allergic (44%) and non-hemolytic febrile reactions (42%). It is essential to state that 91% of adverse reactions were slight ones, and only 5% led to the injury. Out of 96 patients with complications, 79 patients received blood products as pack cells; 6 patients received Fresh Frozen Plasma; 3 patients received autologous blood products, while this number was one for Blood Low Leukocytes and platelets (PLT). Conclusion: Based on this investigation, the risk of adverse transfusion reactions (ATRs) is 4%, and universally 85 million units of blood products are transfused every year. Consequently, investigation to reduce this number is required.
Published: 2022
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18. Gamma-ray puzzle in Cygnus X: Implications for high-energy neutrinos

Author: Tova M. Yoast-Hull, John S. Gallagher, Francis Halzen, Ali Kheirandish, and Ellen G. Zweibel
Published: 2017
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19. High-Energy and Ultra-High-Energy Neutrinos: A Snowmass White Paper

Author: Markus Ackermann, Mauricio Bustamante, Lu Lu, Nepomuk Otte, Mary Hall Reno, Stephanie Wissel, Sanjib K. Agarwalla, Jaime Alvarez-Muñiz, Rafael Alves Batista, Carlos A. Argüelles, Brian A. Clark, Austin Cummings, Sudipta Das, Valentin Decoene, Peter B. Denton, Damien Dornic, Zhan-Arys Dzhilkibaev, Yasaman Farzan, Alfonso Garcia, Maria Vittoria Garzelli, Christian Glaser, Aart Heijboer, Jörg R. Hörandel, Giulia Illuminati, Yu Seon Jeong, John L. Kelley, Kevin J. Kelly, Ali Kheirandish, Spencer R. Klein, John F. Krizmanic, Michael J. Larson, Kohta Murase, Ashish Narang, Remy L. Prechelt, Steven Prohira, Elisa Resconi, Marcos Santander, Victor B. Valera, Justin Vandenbroucke, Olga Vasil'evna Suvorova, Lawrence Wiencke, Shigeru Yoshida, Tianlu Yuan, Enrique Zas, Pavel Zhelnin, Bei Zhou, Luis A. Anchordoqui, Yosuke Ashida, Mahdi Bagheri, Aswathi Balagopal, Vedant Basu, James Beatty, Keith Bechtol, Nicole Bell, Abigail Bishop, Julia Book, Anthony Brown, Alexander Burgman, Michael Campana, Nhan Chau, Thomas Y. Chen, Alan Coleman, Amy Connolly, Janet M. Conrad, Pablo Correa, Cyril Creque-Sarbinowski, Zachary Curtis-Ginsberg, Paramita Dasgupta, Simon De Kockere, Krijn de Vries, Cosmin Deaconu, Abhishek Desai, Tyce DeYoung, Armando di Matteo, Dominik Elsaesser, Phillip Fürst, Kwok Lung Fan, Anatoli Fedynitch, Derek Fox, Erik Ganster, Martin Ha Minh, Christian Haack, Steffen Hallman, Francis Halzen, Andreas Haungs, Aya Ishihara, Eleanor Judd, Timo Karg, Albrecht Karle, Teppei Katori, Alina Kochocki, Claudio Kopper, Marek Kowalski, Ilya Kravchenko, Naoko Kurahashi, Mathieu Lamoureux, Hermes León Vargas, Massimiliano Lincetto, Qinrui Liu, Jim Madsen, Yuya Makino, Joseph Mammo, Zsuzsa Marka, Eric Mayotte, Kevin Meagher, Maximilian Meier, Lino Miramonti, Marjon Moulai, Katharine Mulrey, Marco Muzio, Richard Naab, Anna Nelles, William Nichols, Alisa Nozdrina, Erin O'Sullivan, Vivian OD́ell, Jesse Osborne, Vishvas Pandey, Ek Narayan Paudel, Alex Pizzuto, Mattias Plum, Carlos Pobes Aranda, Lilly Pyras, Christoph Raab, Zoe Rechav, Juan Rojo, Oscar Romero Matamala, Pierpaolo Savina, Frank Schroeder, Lisa Schumacher, Sergio Sciutto, Stephen Sclafani, Mohammad Ful Hossain Seikh, Manuel Silva, Rajeev Singh, Daniel Smith, Samuel Timothy Spencer, Robert Wayne Springer, Juliana Stachurska, Olga Suvorova, Ignacio Taboada, Simona Toscano, Matias Tueros, Jean Pierre Twagirayezu, Nick van Eijndhoven, Péter Veres, Abigail Vieregg, Winnie Wang, Nathan Whitehorn, Walter Winter, Emre Yildizci, Shiqi Yu, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Faculty of Sciences and Bioengineering Sciences, Elementary Particle Physics, and Physics
Subjects: Astrophysics and Astronomy, neutrino: energy: high, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, Baikal, WIMP: dark matter, neutrino: flux, IceCube, neutrino: decay, neutrino: energy, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], neutrino: supernova, numerical calculations, KM3NeT, Particle Physics - Phenomenology, astro-ph.HE, new physics, hep-ex, ANITA, Astronomy and Astrophysics, hep-ph, neutrino: UHE, neutrino: propagation, neutrino: detector, Space and Planetary Science, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Particle Physics - Experiment
Abstract: Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. They are sensitive to physics both within and beyond the Standard Model through their production mechanisms and in their propagation over cosmological distances. They carry unique information about their extreme non-thermal sources by giving insight into regions that are opaque to electromagnetic radiation. This white paper describes the opportunities astrophysical neutrino observations offer for astrophysics and high-energy physics, today and in coming years. Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. They are sensitive to physics both within and beyond the Standard Model through their production mechanisms and in their propagation over cosmological distances. They carry unique information about their extreme non-thermal sources by giving insight into regions that are opaque to electromagnetic radiation. This white paper describes the opportunities astrophysical neutrino observations offer for astrophysics and high-energy physics, today and in coming years.
Published: 2022
Full Text: View/download PDF

20. Searching for VHE gamma-ray emission associated with IceCube neutrino alerts using FACT, H.E.S.S., MAGIC, and VERITAS

Author: Konstancja, Satalecka, Acciari, Victor A., Stefano, Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel, Artero, Katsuaki, Asano, Dominik, Baack, Ana, Babic, Andr('(e))s, Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana, Batkovi('(c)), Josefa Becerra Gonzalez, Wlodek, Bednarek, Lorenzo, Bellizzi, Elisa, Bernardini, Maria-Isabel, Bernardos, Alessio, Berti, Jürgen, Besenrieder, Wrijupan, Bhattacharyya, Ciro, Bigongiari, Adrian, Biland, Oscar, Blanch, Hendrik, Bökenkamp, Giacomo, Bonnoli, Zeljka, Bosnjak, Giovanni, Busetto, Roberto, Carosi, Giovanni, Ceribella, Matteo, Cerruti, Yating, Chai, Ashot, Chilingarian, Stefan, Cikota, Sidika Merve Colak, Eduardo, Colombo, Jose Luis Contreras, Juan, Cortina, Stefano, Covino, Giacomo D( extquotesingle)Amico, Valerio D( extquotesingle)Elia, Paolo Da Vela, Francesco, Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel, Delfino, Jordi, Delgado, Carlos Delgado Mendez, Davide, Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espi(~(n))eira, Dijana Dominis Prester, Alice, Donini, Daniela, Dorner, Michele, Doro, Dominik, Elsaesser, Vandad Fallah Ramazani, Alicia, Fattorini, Maria Victoria Fonseca, Lluis, Font, Christian, Fruck, Satoshi, Fukami, Yasushi, Fukazawa, Garc('(i))a L('(o))pez, Ramon J., Markus, Garczarczyk, Sargis, Gasparyan, Markus, Gaug, Giglietto, Nicola, Francesco, Giordano, Pawel, Gliwny, Nikola, Godinovic, David, Green, Jarred Gershon Green, Daniela, Hadasch, Alexander, Hahn, Lea, Heckmann, Javier, Herrera, John, Hoang, Dario, Hrupec, Moritz, Hütten, Tomohiro, Inada, Kazuma, Ishio, Yuki, Iwamura, Irene Jim('(e))nez Mart('(i))nez, Jenni, Jormanainen, L('(e))a, Jouvin, Marie, Karjalainen, Daniel, Kerszberg, Yukiho, Kobayashi, Hidetoshi, Kubo, Junko, Kushida, Alessandra, Lamastra, Damir, Lelas, Francesco, Leone, Elina, Lindfors, Lena, Linhoff, Saverio, Lombardi, Francesco, Longo, Ruben, Lopez-Coto, Marcos, L('(o))pez-Moya, Alicia, L('(o))pez-Oramas, Loporchio, Serena, Bernardo Machado de Oliveira Fraga, Camilla, Maggio, Pratik, Majumdar, Martin, Makariev, Manuela, Mallamaci, Galina, Maneva, Marina, Manganaro, Karl, Mannheim, Laura, Maraschi, Mos(`(e)), Mariotti, Manel, Martinez, Daniel, Mazin, Stefano, Menchiari, Simone, Mender, Sa( (s))a Mi('(c))anovi('(c)), Davide, Miceli, Tjark, Miener, Jose Miguel Miranda, Razmik, Mirzoyan, Edgar, Molina, Abelardo, Moralejo, Daniel, Morcuende, Victoria, Moreno, Elena, Moretti, Takeshi, Nakamori, Lara, Nava, Vitaly, Neustroev, Cosimo, Nigro, Kari, Nilsson, Kyoshi, Nishijima, Koji, Noda, Seiya, Nozaki, Yoshiki, Ohtani, Tomohiko, Oka, Jorge, Otero-Santos, Simona, Paiano, Michele, Palatiello, David, Paneque, Riccardo, Paoletti, Paredes, Josep M., Lovro, Pavleti('(c)), Pablo, Pe(~(n))il, Massimo, Persic, Marine, Pihet, Pier Giorgio Prada Moroni, Elisa, Prandini, Chaitanya, Priyadarshi, Ivica, Puljak, Wolfgang, Rhode, Marc, Rib('(o)), Javier, Rico, Chiara, Righi, Andrea, Rugliancich, Narek, Sahakyan, Takayuki, Saito, Shunsuke, Sakurai, Francesco Gabriele Saturni, Bernd, Schleicher, Kevin, Schmidt, Thomas, Schweizer, Julian, Sitarek, Iva, ( (S))nidari('(c)), Dorota, Sobczy('(n))ska, Alessia, Spolon, Antonio, Stamerra, Jelena Stri( (s))kovi('(c)), Derek, Strom, Marcel, Strzys, Yusuke, Suda, Tihomir, Suri('(c)), Mitsunari, Takahashi, Ryuji, Takeishi, Fabrizio, Tavecchio, Petar, Temnikov, Tomislav, Terzic, Masahiro, Teshima, Luca, Tosti, Stefano, Truzzi, Antonio, Tutone, Santiago, Ubach, Juliane van Scherpenberg, Gaia, Vanzo, Monica VAZQUEZ ACOSTA, Sofia, Ventura, Vassil, Verguilov, Carlo Francesco Vigorito, Vincenzo, Vitale, Ievgen, Vovk, Martin, Will, Carolin, Wunderlich, Tokonatsu, Yamamoto, Darko, Zari('(c)), Matteo, Balbo, Thomas, Bretz, Jens, Buss, Laura, Eisenberger, Dorothee, Hildebrand, Roman, Iotov, Adelina, Kalenski, Dominik, Neise, Maximilian, Noethe, Aleksander, Paravac, Vitalii, Sliusar, Roland, Walter, Rasha, Abbasi, Markus, Ackermann, Jenni, Adams, Juanan, Aguilar, Ahlers, M., Maryon, Ahrens, Cyril Martin Alispach, Antonio Augusto Alves Junior, Najia Moureen Binte Amin, Rui, An, Karen, Andeen, Tyler, Anderson, Gisela, Anton, Carlos, Arguelles, Yosuke, Ashida, Spencer, Axani, Xinhua, Bai, Aswathi Balagopal, V., Anastasia Maria Barbano, Barwick, S. W., Benjamin, Bastian, Vedant, Basu, Sebastian, Baur, Bay, R. C., Beatty, J. J., Becker, K. -H., Julia Becker Tjus, Chiara, Bellenghi, Segev, Benzvi, Berley, D., Besson, D. Z., Gary, Binder, Daniel, Bindig, Blaufuss, E., Summer, Blot, Matthias, Boddenberg, Federico, Bontempo, Jurgen, Borowka, Boser, S., Olga, Botner, Jakob, Bottcher, Etienne, Bourbeau, Federica, Bradascio, Braun, J., Stephanie, Bron, Jannes, Brostean-Kaiser, Sally-Ann, Browne, Alexander, Burgman, Ryan, Burley, Raffaela, Busse, Michael, Campana, Erin, Carnie-Bronca, Chujie, Chen, Dmitry, Chirkin, Koun, Choi, Bryanlee, Clark, Kenneth, Clark, Lew, Classen, Alan, Coleman, Gabriel, Collin, Conrad, J. M., Paul, Coppin, Pablo, Correa, Cowen, D. F., Cross, R., Christian, Dappen, Pranav, Dave, Catherine DE CLERCQ, James, Delaunay, Hans, Dembinski, Kunal, Deoskar, Sam De Ridder, Abhishek, Desai, Paolo, Desiati, Krijn de Vries, Gwenhaël de Wasseige, Meike De With, Tyce, Deyoung, Sukeerthi, Dharani, Alejandro, Diaz, Juan Carlos Diaz-Velez, Markus, Dittmer, Hrvoje, Dujmovic, Matt, Dunkman, Michael, Duvernois, Emily, Dvorak, Thomas, Ehrhardt, Philipp, Eller, Ralph, Engel, Hannah, Erpenbeck, John, Evans, Evenson, P. A., Kwok Lung Fan, Fazely, A. R., Sebastian, Fiedlschuster, Aaron, Fienberg, Kirill, Filimonov, Chad, Finley, Leander, Fischer, Derek, B Fox, Anna, Franckowiak, Elizabeth, Friedman, Alexander, Fritz, Philipp, Furst, Gaisser, T. K., Jay, Gallagher, Erik, Ganster, Alfonso, Garcia, Simone, Garrappa, Gerhardt, L., Ava, Ghadimi, Christian, Glaser, Theo, Glauch, Thorsten, Glusenkamp, Goldschmidt, A., Javier, Gonzalez, Sreetama, Goswami, Darren, Grant, Timoth('(e))e, Gr('(e))goire, Spencer, Griswold, Mehmet, Gunduz, Christoph, Günther, Christian, Haack, Allan, Hallgren, Halliday, R., Halve, L., Halzen, F., Martin Ha Minh, Kael, Hanson, John, Hardin, Harnisch, Alexander A., Andreas, Haungs, Simon, Hauser, Dustin, Hebecker, Helbing, K., Felix, Henningsen, Hettinger, Emma C., Stephanie, Hickford, Joshua, Hignight, Colton, Hill, Hill, G. C., Kara, Hoffman, Ruth, Hoffmann, Tobias, Hoinka, Benjamin, Hokanson-Fasig, Hoshina, K., Feifei, Huang, Matthias, Huber, Thomas, Huber, Klas, Hultqvist, Mirco, Hunnefeld, Raamis, Hussain, Seongjin, In, Nad(`(e))ge, Iovine, Aya, Ishihara, Matti, Jansson, George, Japaridze, Minjin, Jeong, Ben, Jones, Donghwa, Kang, Woosik, Kang, Xinyue, Kang, Alexander, Kappes, David, Kappesser, Timo, Karg, Martina, Karl, Karle, A., Katz, U., Kauer, M., Moritz, Kellermann, Kelley, J. L., Ali, Kheirandish, Ken( extquotesingle)ichi Kin, Thomas, Kintscher, Joanna, Kiryluk, Spencer, Klein, Ramesh, Koirala, Hermann, Kolanoski, Tomas, Kontrimas, Lutz, Kopke, Claudio, Kopper, Sandro, Kopper, Koskinen, D. J., Paras, Koundal, Michael, Kovacevich, Marek, Kowalski, Tetiana, Kozynets, Emma, Kun, Naoko, Kurahashi, Neha, Lad, Cristina Lagunas Gualda, Justin, Lanfranchi, Michael, J Larson, Frederik Hermann Lauber, Jeffrey, Lazar, Jiwoong, Lee, Kayla, Leonard, Agnieszka, Leszczy('(n))ska, Yijia, Li, Massimiliano, Lincetto, Qinrui, Liu, Maria, Liubarska, Elisa, Lohfink, Cristian Jesus Lozano Mariscal, Lu, Lu, Francesco, Lucarelli, Andrew, Ludwig, William, Luszczak, Yang, Lyu, Wing Yan Ma, James, Madsen, Kendall, Mahn, Yuya, Makino, Sarah, Mancina, Ioana Codrina Maris, Maruyama, Reina H., Mase, K., Thomas, Mcelroy, Frank, Mcnally, James Vincent Mead, Meagher, K., Andres, Medina, Maximilian, Meier, Stephan, Meighen-Berger, Jessie, Micallef, Daniela, Mockler, Teresa, Montaruli, Roger, Moore, Morse, R., Marjon, Moulai, Richard, Naab, Ryo, Nagai, Uwe, Naumann, Jannis, Necker, Le Viet Nguyen, Hans, Niederhausen, Mehr, Nisa, Sarah, Nowicki, Dave, Nygren, Anna Obertacke Pollmann, Marie, Oehler, Olivas, A., Erin O( extquotesingle)Sullivan, Hershal, Pandya, Daria, Pankova, Nahee, Park, Grant, Parker, Ek Narayan Paudel, Larissa, Paul, Carlos Perez de los Heros, Lilly, Peters, Saskia, Philippen, Damian, Pieloth, Sarah, Pieper, Martin, Pittermann, Pizzuto, A., Plum, M., Yuiry, Popovych, Alessio, Porcelli, Maria Prado Rodriguez, Buford Price, P., Brandom, Pries, Gerald, Przybylski, Christoph, Raab, Amirreza, Raissi, Mohamed, Rameez, Rawlins, K., Immacolata Carmen Rea, Abdul, Rehman, Ren('(e)), Reimann, Giovanni, Renzi, Elisa, Resconi, Simeon, Reusch, Mike, Richman, Benedikt, Riedel, Ella, Roberts, Sally, Robertson, Gerrit, Roellinghoff, Martin, Rongen, Carsten, Rott, Tim, Ruhe, Dirk, Ryckbosch, Devyn Rysewyk Cantu, Ibrahim, Safa, Julian, Saffer, Sebastian Sanchez Herrera, Alexander, Sandrock, Joakim, Sandroos, Marcos, Santander, Subir, Sarkar, Sourav, Sarkar, Maximilian Karl Scharf, Merlin, Schaufel, Harald, Schieler, Sebastian, Schindler, Schlunder, P., Torsten, Schmidt, Austin, Schneider, Judith, Schneider, Schröder, Frank G., Lisa Johanna Schumacher, Georg, Schwefer, Steve, Sclafani, Seckel, D., Surujhdeo, Seunarine, Ankur, Sharma, Shefali, Shefali, Manuel, Silva, Barbara, Skrzypek, Ben, Smithers, Robert, Snihur, Jan, Soedingrekso, Dennis, Soldin, Christian, Spannfellner, Glenn, Spiczak, Christian, Spiering, Juliana, Stachurska, Michael, Stamatikos, Stanev, T., Robert, Stein, Joeran, Stettner, Steuer, A., Stezelberger, T., Timo, Sturwald, Thomas, Stuttard, Sullivan, G. W., Taboada, I., Frederik, Tenholt, Samvel, Ter-Antonyan, Tilav, S., Franziska, Tischbein, Kirsten, Tollefson, Christoph, Tönnis, Simona, Toscano, Delia, Tosi, Alexander, Trettin, Maria, Tselengidou, Chunfai, Tung, Andrea, Turcati, Roxanne, Turcotte, Colin, Turley, Jean Pierre Twagirayezu, Bunheng, Ty, Martin Unland Elorrieta, Nora, Valtonen-Mattila, Justin, Vandenbroucke, Nick van Eijndhoven, David, Vannerom, Jakob van Santen, Stef, Verpoest, Matthias, Vraeghe, Walck, C., Timothyblake, Watson, Chris, Weaver, Philip, Weigel, Andreas, Weindl, Matthew, Weiss, Jan, Weldert, Chris, Wendt, Johannes, Werthebach, Mark, Weyrauch, Nathan, Whitehorn, Wiebusch, C. H., Dawn, Williams, Martin, Wolf, Kurt, Woschnagg, Gerrit, Wrede, Johan, Wulff, Xianwu, Xu, Yiqian, Xu, Juan Pablo Yanez, Yoshida, S., Shiqi, Yu, Tianlu, Yuan, Zelong, Zhang, Weidong, Jin, Hassan, Abdalla, Felix, Aharonian, Faical, Ait-Benkhali, Oguzhan, Anguener, Cornelia, Arcaro, Celine, Armand, Tom, Armstrong, Halim, Ashkar, Michael, Backes, Vardan, Baghmanyan, Victor Barbosa Martins, Anna, Barnacka, Monica, Barnard, Rowan, Batzofin, Yvonne, Becherini, David, Berge, Konrad, Bernlöhr, Baiyang, Bi, Markus, Boettcher, Catherine, Boisson, Julien, Bolmont, Mathieu de Bony, Mischa, Breuhaus, Robert, Brose, Francois, Brun, Tomasz, Bulik, Thomas, Bylund, Floriane, Cangemi, Sami, Caroff, Sabrina, Casanova, Jaqueline, Catalano, Pauline, Chambery, Tej Bahadur Chand, Andrew, Chen, Garret, Cotter, Malgorzata, Curlo, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James, Davies, Justine, Devin, Arache, Djannati-Ataï, Anton, Dmytriiev, Axel, Donath, Victor, Doroshenko, Lente, Dreyer, Louis Du Plessis, Connor, Duffy, Kathrin, Egberts, Sabrina, Einecke, Gabriel, Emery, Jean-Pierre, Ernenwein, Steven, Fegan, Kirsty, Feijen, Armand, Fiasson, Gaëtan Fichet de Clairfontaine, Gerard, Fontaine, Lott, Frans, Matthias, Fuessling, Stefan, Funk, Stefano, Gabici, Yves, Gallant, Shahede, Ghafourizade, Gianluca, Giavitto, Luca, Giunti, Dorit, Glawion, Jean-Francois, Glicenstein, Marie-H('(e))l(`(e))ne, Grondin, Sumari, Hattingh, Maria, Haupt, German, Hermann, Jim, Hinton, Werner, Hofmann, Clemens, Hoischen, Tim, Holch, Markus, Holler, Dieter, Horns, Zhiqiu, Huang, David, Huber, Mario, Hörbe, Marek, Jamrozy, Felix, Jankowsky, Vikas, Joshi, Ira, Jung, Eli, Kasai, Krzysztof, Katarzynski, Ul(`(i)), Katz, Dmitry, Khangulyan, Bruno, Khelifi, Stefan, Klepser, Wlodek, Kluzniak, Nukri, Komin, Ruslan, Konno, Karl, Kosack, Dmitriy, Kostunin, Michael, Kreter, Ga( (s))per Kukec Mezek, Anu, Kundu, Giovanni, Lamanna, S('(e))bastien Le Stum, Anne, Lemiere, Marianne, Lemoine-Goumard, Jean-Philippe, Lenain, Fabian, Leuschner, Christelle, Levy, Thomas, Lohse, Anna, Luashvili, Iryna, Lypova, Jonathan, Mackey, Jhilik, Majumdar, Denys, Malyshev, Dmitry, Malyshev, Vincent, Marandon, Paolo, Marchegiani, Alexandre, Marcowith, Arnaud, Mares, Guillem Marti( extquotesingle)i-Devesa, Ramin, Marx, Gilles, Maurin, Pieter, Meintjes, Manuel, Meyer, Alison, Mitchell, Rafal, Moderski, Lars, Mohrmann, Alessandro, Montanari, Chris, Moore, Paul, Morris, Emmanuel, Moulin, Jacques, Muller, Thomas, Murach, Kaori, Nakashima, Mathieu Naurois (de), Amid, Nayerhoda, Hambeleleni, Ndiyavala, Jacek, Niemiec, Angel, Noel, Paul O( extquotesingle)Brien, Laenita Lorraine Oberholzer, Stefan, Ohm, Laura, Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal, Ostrowski, Sebastian, Panny, Michael, Panter, Dan, Parsons, Giada, Peron, Santiago, Pita, Vincent, Poireau, Dmitry, Prokhorov, Heike, Prokoph, Gerd, Puehlhofer, Michael, Punch, Andreas, Quirrenbach, Patrick, Reichherzer, Anita, Reimer, Olaf, Reimer, Quentin, Remy, Matthieu, Renaud, Brian, Reville, Frank, Rieger, Carlo, Romoli, Gavin, Rowell, Bronislaw, Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan, Sahakian, Simon, Sailer, Heiko, Salzmann, David, Sanchez, Andrea, Santangelo, Manami, Sasaki, Johannes, Schaefer, Hester, Schutte, Ullrich, Schwanke, Fabian, Schüssler, Mohanraj, Senniappan, Albert, Seyffert, Shapopi, Jimmy N. S., Kleopas, Shiningayamwe, Rachel, Simoni, Atreyee, Sinha, Helene, Sol, Hugh, Spackman, Andreas, Specovius, Samuel Timothy Spencer, Marion, Spir-Jacob, Lukasz, Stawarz, Riaan, Steenkamp, Christian, Stegmann, Simon, Steinmassl, Constantin, Steppa, Lei, Sun, Tadayuki, Takahashi, Takaaki, Tanaka, Thomas, Tavernier, Andrew, Taylor, Regis, Terrier, Hannes, Thiersen, Charles, Thorpe-Morgan, Martin, Tluczykont, Lenka, Tomankova, Michelle, Tsirou, Naomi, Tsuji, Richard, Tuffs, Yasunobu, Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George, Vasileiadis, Johannes, Veh, Christo, Venter, Pascal, Vincent, Jacco, Vink, Völk, Heinrich J., Stefan, Wagner, Jason John Watson, Felix, Werner, Richard, White, Alicja, Wierzcholska, Yu Wun Wong, Hend, Yassin, Anke, Yusafzai, Michael, Zacharias, Roberta, Zanin, Davit, Zargaryan, Andrzej, Zdziarski, Andreas, Zech, Sylvia, Zhu, Andreas, Zmija, Samuel, Zouari, Natalia, Zywucka, The FACT Collaboration, The H.E.S.S. Collaboration, The IceCube Collaboration, The MAGIC Collaboration, The VERITAS Collaboration, and Współautorami artykułu są członkowie Magic Collaboration, IceCube Collaboration, FACT Collaboration, H.E.S.S. Collaboration, VERITAS Collaboration w liczbie 808
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Point source, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, IACT, Astrophysics, law.invention, High Energy Physics - Experiment, Telescope, High Energy Physics - Experiment (hep-ex), law, HESS - Abteilung Hinton, ddc:530, High Energy Physics::Experiment, MAGIC (telescope), Neutrino, Blazar, Astrophysics - High Energy Astrophysical Phenomena, Cherenkov radiation
Abstract: The realtime follow-up of neutrino events is a promising approach to search for astrophysical neutrino sources. It has so far provided compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 observed in coincidence with the high-energy neutrino IceCube-170922A detected by IceCube. The detection of very-high-energy gamma rays (VHE, $\mathrm{E} > 100\,\mathrm{GeV}$) from this source helped establish the coincidence and constrained the modeling of the blazar emission at the time of the IceCube event. The four major imaging atmospheric Cherenkov telescope arrays (IACTs) - FACT, H.E.S.S., MAGIC, and VERITAS - operate an active follow-up program of target-of-opportunity observations of neutrino alerts sent by IceCube. This program has two main components. One are the observations of known gamma-ray sources around which a cluster of candidate neutrino events has been identified by IceCube (Gamma-ray Follow-Up, GFU). Second one is the follow-up of single high-energy neutrino candidate events of potential astrophysical origin such as IceCube-170922A. GFU has been recently upgraded by IceCube in collaboration with the IACT groups. We present here recent results from the IACT follow-up programs of IceCube neutrino alerts and a description of the upgraded IceCube GFU system., Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06966 for all IceCube contributions. See arXiv:2108.05257 for all H.E.S.S. contributions
Published: 2022

21. Prospects for Identifying Bright Seyfert Galaxies in Current & Future Neutrino Telescopes

Author: Ali Kheirandish, K. Murase, and S. S. Kimura
Subjects: Neutrino Telescopes and MultiMessenger Investigations
Abstract: Parallel Contributed Talk at the "XIX International Workshop on Neutrino Telescopes" on line - 18-26 February, 2021, {"references":["arXiv: 2102.04475"]}
Published: 2021
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22. Searching for Dark Matter from the Sun with the IceCube Detector

Author: Lisa Johanna Schumacher, Elisa Lohfink, Javier Gonzalez, Roxanne Turcotte, Catherine De Clercq, Michael DuVernois, Barbara Skrzypek, Larissa Paul, Naoko Kurahashi, Frank G. Schröder, Thomas McElroy, Erin O'Sullivan, S. Böser, Gerald Przybylski, Jakob van Santen, Shiqi Yu, Federica Bradascio, Alexander Burgman, Simeon Reusch, K. Meagher, Mehr Nisa, Benedikt Riedel, Stephanie Hickford, Delia Tosi, Sebastian Baur, Sebastian Fiedlschuster, Markus Ackermann, S. W. Barwick, Sreetama Goswami, Ken'ichi Kin, Ryan Burley, A. Steuer, Qinrui Liu, Martina Karl, Raamis Hussain, Aaron Fienberg, John Evans, Amirreza Raissi, U. Katz, Sally Robertson, Judith Schneider, Andres Medina, Donghwa Kang, Merlin Schaufel, Dawn Williams, Martin Pittermann, Chris Weaver, Stephanie Bron, K. Hoshina, Hrvoje Dujmovic, Jurgen Borowka, Benjamin Bastian, Anastasia Maria Barbano, Brian Clark, Sebastian Sanchez Herrera, Glenn Spiczak, Zelong Zhang, Michael Stamatikos, Jan Soedingrekso, P. Schlunder, John Hardin, Spencer Axani, Kael Hanson, Saskia Philippen, D. F. Cowen, A. Goldschmidt, Julia Becker Tjus, Markus Ahlers, Martin Unland Elorrieta, Shefali Shefali, C. Walck, Alfonso Garcia, Ankur Sharma, Jeffrey Lazar, Le Viet Nguyen, J. J. Beatty, Tianlu Yuan, Matthias Vraeghe, Torsten Schmidt, Abdul Rehman, Carsten Rott, Dave Nygren, Mohamed Rameez, Cyril Martin Alispach, Karen Andeen, Felix Henningsen, Tyler Anderson, Surujhdeo Seunarine, Thomas K. Gaisser, Timo Karg, Hermann Kolanoski, Carlos Arguelles, Lutz Kopke, Chiara Bellenghi, Thomas Kintscher, Maximilian Meier, Jessie Micallef, Juan Pablo Yanez, IceCube, Josh Peterson, Emma Kun, Paolo Desiati, Matthias Huber, Juanan Aguilar, Lenka Tomankova, Yosuke Ashida, A. R. Fazely, J. L. Kelley, Kenneth Clark, Aya Ishihara, Matthew Weiss, Yuiry Popovych, Kirill Filimonov, Pranav Dave, Maximilian Karl Scharf, Alejandro Diaz, Krijn de Vries, Stef Verpoest, Andreas Weindl, Jenni Adams, Xianwu Xu, Jay Gallagher, Minjin Jeong, K.-H. Becker, Ruth Hoffmann, Kwok Lung Fan, Alexander Fritz, Colin Turley, Erik Ganster, Najia Moureen Binte Amin, Uwe Naumann, T. Stanev, Yiqian Xu, Emma C. Hettinger, Matt Dunkman, Federico Bontempo, Nora Valtonen-Mattila, Marcos Santander, Francesco Lucarelli, Maria Liubarska, Ramesh Koirala, Dennis Soldin, Martin Ha Minh, Hans Dembinski, Erin Carnie-Bronca, Harald Schieler, K. Rawlins, Christian Glaser, Simona Toscano, Christian Spiering, Manuel Silva, Samvel Ter-Antonyan, Ben Jones, Alan Coleman, Gisela Anton, Maria Prado Rodriguez, Devyn Rysewyk Cantu, Gwenhaël de Wasseige, D. Z. Besson, Reina H. Maruyama, R. Halliday, Daniel Bindig, Georg Schwefer, L. Gerhardt, James Vincent Mead, Thomas Stuttard, Ryo Nagai, A. Olivas, E. Blaufuss, T. Stezelberger, Sarah Pieper, Markus Dittmer, Jannis Necker, Tetiana Kozynets, Neha Lad, Dirk Ryckbosch, Elizabeth Friedman, Chad Finley, Rasha Abbasi, Summer Blot, Matthias Boddenberg, Ibrahim Safa, Daria Pankova, Damian Pieloth, Ali Kheirandish, Sarah Mancina, Gerrit Roellinghoff, Stephan Meighen-Berger, Jannes Brostean-Kaiser, Kurt Woschnagg, Simon Hauser, Anna Franckowiak, Tobias Hoinka, Vedant Basu, James Madsen, Thorsten Glusenkamp, Massimiliano Lincetto, Lu Lu, Paul Evenson, S. Yoshida, I. Taboada, Dustin Hebecker, Nathan Whitehorn, Steve Sclafani, Klas Hultqvist, Joanna Kiryluk, Christoph Tönnis, Sally-Ann Browne, Brandom Pries, Mirco Hunnefeld, Marie Oehler, Segev BenZvi, Timothée Grégoire, Paras Koundal, Mike Richman, Colton Hill, Carlos Perez de los Heros, Gabriel Collin, Simone Garrappa, Dmitry Chirkin, Johan Wulff, Jan Weldert, Etienne Bourbeau, Spencer Klein, Julian Saffer, Chris Wendt, Sebastian Schindler, Michael Kovacevich, Pablo Correa, S. Tilav, Teresa Montaruli, Christoph Günther, Alexander Kappes, Michael Campana, Emily Dvorak, Cristian Jesus Lozano Mariscal, Kendall Mahn, K. Helbing, Elisa Bernardini, Tomas Kontrimas, Christian Dappen, Justin Vandenbroucke, Timothyblake Watson, Yijia Li, Sourav Sarkar, Benjamin Hokanson-Fasig, L. Halve, Philipp Eller, Christian Spannfellner, R. Morse, Frank McNally, Chunfai Tung, Olga Botner, Jakob Bottcher, Kara Hoffman, D. J. Koskinen, Antonio Augusto Alves Junior, Chujie Chen, Raffaela Busse, Anna Obertacke Pollmann, Yang Lyu, Joeran Stettner, Cristina Lagunas Gualda, Grant Parker, Philip Weigel, M. Plum, Mehmet Gunduz, Agnieszka Leszczyńska, R. C. Bay, Hershal Pandya, Martin Rongen, Wolfgang Rhode, Spencer Griswold, Maryon Ahrens, Joshua Hignight, Timo Sturwald, Frederik Tenholt, Wing Yan Ma, Feifei Huang, Hannah Erpenbeck, Konstancja Satalecka, Theo Glauch, Xinhua Bai, Austin Schneider, Abhishek Desai, Juan Carlos Diaz-Velez, Robert Stein, Maria Tselengidou, James DeLaunay, Marjon Moulai, Ava Ghadimi, Martin Wolf, Franziska Tischbein, Hans Niederhausen, Robert A. Cross, Frederik Hermann Lauber, Koun Choi, Andrew Ludwig, Justin Lanfranchi, Ben Smithers, Jean Pierre Twagirayezu, Jiwoong Lee, Rui An, Nahee Park, Darren Grant, Derek B Fox, Immacolata Carmen Rea, Sarah Nowicki, Andreas Haungs, Robert Snihur, C. H. Wiebusch, Kunal Deoskar, A. Karle, Ioana Codrina Maris, Sam De Ridder, Christoph Raab, Nadège Iovine, D. Berley, G. C. Hill, Bunheng Ty, Patrick Reichherzer, Ralph Engel, Moritz Kellermann, Giovanni Renzi, D. Seckel, Tyce DeYoung, George Japaridze, Roger Moore, Woosik Kang, Richard Naab, Marek Kowalski, Seongjin In, Elisa Resconi, Jan Conrad, K. Mase, Yuya Makino, Alessio Porcelli, Alexander A. Harnisch, Nick van Eijndhoven, Lew Classen, René Reimann, Leander Fischer, Thomas Ehrhardt, Christian Haack, Alexander Sandrock, Kirsten Tollefson, Kayla Leonard, Alexander Trettin, Sukeerthi Dharani, Francis Halzen, Lilly Peters, Juliana Stachurska, V Aswathi Balagopal, Gerrit Wrede, Johannes Werthebach, Thomas Huber, Ek Narayan Paudel, Michael J Larson, Allan Hallgren, Sandro Kopper, William Luszczak, M. Kauer, David Kappesser, Matti Jansson, P. Buford Price, Mark Weyrauch, Joakim Sandroos, Daniela Mockler, G. W. Sullivan, James E. Braun, Philipp Furst, Tim Ruhe, Paul Coppin, Andrea Turcati, Ella Roberts, Alex Pizzuto, Gary Binder, Xinyue Kang, Claudio Kopper, Subir Sarkar, and David Vannerom
Subjects: Physics, Dark matter, Detector, Astronomy
Published: 2021
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23. Endoplasmic reticulum as a therapeutic target in type 2 diabetes: Role of phytochemicals

Author: Soraya, Sajadimajd, Niloofar, Deravi, Kimia, Forouhar, Roja, Rahimi, Ali, Kheirandish, and Roodabeh, Bahramsoltani
Subjects: Pharmacology, Immunology, Immunology and Allergy
Abstract: Type 2 diabetes mellitus (T2DM) is a metabolic disorders characterized by insulin resistance and β-cell dysfunction with an increasing worldwide incidence. Several studies have revealed that long-term glucotoxicity results in β-cell failure and death through induction of endoplasmic reticulum (ER) stress. Owing to the chronic progression of T2DM and the low effectiveness of antidiabetic drugs in long-term use, medicinal plants and their secondary metabolites seem to be the promising alternatives. Here we have provided a comprehensive review regarding the role of phytochemicals to alleviate ER stress in T2DM. Ginsenoside compound K, baicalein, quercetin, isopulegol, kaempferol, liquiritigenin, aspalathin, and tyrosol have demonstrated remarkable improvement of T2DM via modulation of ER stress. Arctigenin and total glycosides of peony have been shown to be effective in the treatment of diabetic retinopathy through modulation of ER stress. The effectiveness of grape seed proanthocyanidins and wolfberry is also shown in the relief of diabetic neuropathy and retinopathy. Resveratrol is involved in the prevention of atherosclerosis via ER stress modulation. Taken together, the data described herein revealed the capability of herbal constituents to prevent different complications of T2DM via a decrease in ER stress which open new doors to the treatment of diabetes.
Published: 2023
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24. Black holes associated with cosmic neutrino flares

Author: Francis Halzen and Ali Kheirandish
Subjects: Physics, COSMIC cancer database, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, General Physics and Astronomy, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, 010305 fluids & plasmas, 0103 physical sciences, High Energy Physics::Experiment, Neutrino, 010306 general physics, Blazar
Abstract: Astrophysical neutrinos could originate from blazars, but their modelling is challenging. Instead, the source of cosmic neutrinos could be a special yet unidentified class in which jets burrow through stellar material and produce neutrinos.
Published: 2020
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25. Dark Matter Annihilation to Neutrinos: Current Limits and Future Prospects

Author: Ibrahim Safa, Ali Kheirandish, Alejandro Diaz, Aaron C. Vincent, and Carlos Arguelles
Subjects: Physics, Particle physics, Annihilation, Dark matter, Neutrino, Current (fluid)
Published: 2021
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26. TauRunner: A Monte Carlo for Very-High-Energy Tau Neutrino Propagation

Author: Jeffrey Lazar, Carlos Arguelles, Ibrahim Safa, Justin Vandenbroucke, Ali Kheirandish, Oswaldo Vazquez, and Alex Pizzuto
Subjects: Physics, High energy, Particle physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Monte Carlo method, Flux, Python (programming language), Tau neutrino, High Energy Physics::Experiment, Neutrino, computer, Energy (signal processing), computer.programming_language
Abstract: The hunt for cosmogenic neutrinos is a target of next generation observatories: IceCube-Gen2, RNO, GRAND, POEMMA, and CHANT. In a recent publication, a novel detection strategy for these neutrinos has been put forward. This new technique relies on the observation of Earth-throughgoing tau neutrinos at PeV energies. By measuring the flux at this energy, we can indirectly observe the flux at EeV energies since these two are related by the cascading down of the neutrinos. However, such a link demands an accurate simulation of the VHE tau neutrino transport. TauRunner is a Python Monte Carlo (MC) package developed in 2019 that was intended for such effort, but contained some limitations. This contribution will present the newest version of this MC, which now incorporates all the neutrino flavors in the propagation as well as other features.
Published: 2021
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27. χaroν: a tool for neutrino flux generation from WIMPs

Author: Jeffrey Lazar, Ali Kheirandish, Carlos Arguelles, and Qinrui Liu
Subjects: Physics, COSMIC cancer database, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Dark matter, Detector, Gamma ray, Astronomy, Cosmic ray, Observable universe, Astrophysics::Cosmology and Extragalactic Astrophysics, Standard Model, High Energy Physics::Experiment, Neutrino
Abstract: Indirect searches for signatures of corpuscular dark matter have been performed using all cosmic messengers: gamma rays, cosmic rays, and neutrinos. The search for dark matter with neutrinos is important since they are the only courier that can reach detectors from dark matter processes in dense environments, such as the core of the Sun or Earth, or the edge of the observable Universe. One thing essential to experiments is the prediction of the neutrino signature in the detector. I will introduce χaroν, a software that bridges the dark sector and Standard Model by predicting neutrino fluxes from different celestial dark matter agglomerations in diverse scenarios. This package includes an updated computation of neutrino production and propagation to the detector.
Published: 2021
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28. A Convolutional Neural Network based Cascade Reconstruction for the IceCube Neutrino Observatory

Author: J. Werthebach, A. Franckowiak, Chujie Chen, Ioana Codrina Maris, K. Hoshina, A. Steuer, A. Weindl, Maryon Ahrens, P. Schlunder, Saskia Philippen, Glenn Spiczak, G. Momenté, Segev BenZvi, Spencer Klein, M. Rameez, Sam De Ridder, Frederik Tenholt, R. Nagai, D. F. Cowen, Martin Unland Elorrieta, Stephen L. Hauser, Christoph Raab, Nadège Iovine, Barbara Skrzypek, Kara Hoffman, Sarah Mancina, N. van Eijndhoven, U. Naumann, Raamis Hussain, D. Berley, G. C. Hill, Tobias Hoinka, Vedant Basu, Steve Sclafani, J. Kiryluk, B. J. P. Jones, Andres Medina, D. Mockler, Bunheng Ty, Ralph Engel, Moritz Kellermann, U. Katz, Emily Dvorak, Timo Karg, K. Andeen, D. R. Nygren, Marek Kowalski, D. Kang, Giovanni Renzi, K. D. de Vries, M. Stamatikos, Hershal Pandya, Wolfgang Rhode, Robert Stein, A.A. Alves, Pablo Correa, D. Seckel, S. Fahey, Javier Gonzalez, Roxanne Turcotte, Maximilian Karl Scharf, Alexander Trettin, P. B. Price, I. Taboada, Gisela Anton, Michael O. Wolf, Lenka Tomankova, Max Renschler, Y. Makino, Matthias Vraeghe, Tyce DeYoung, K. Tollefson, D. J. Koskinen, K. Rawlins, Nathan Whitehorn, C. Weaver, T. Anderson, B. A. Clark, Francesco Lucarelli, Brandom Pries, L. Schumacher, Devyn Rysewyk Cantu, P. Peiffer, J. Kim, Daria Pankova, E. Friedman, M. Kauer, Alan Coleman, John Hardin, Shefali Shefali, Nora Valtonen-Mattila, M. E. Huber, D. B. Fox, Alexander Fritz, D. Z. Besson, T. O. B. Schmidt, E. Bourbeau, Suyong Choi, M. Silva, Najia Moureen Binte Amin, J. P. Lazar, Sebastian Böser, R. Morse, Spencer Griswold, Jakob Bottcher, T. Montaruli, David A. Williams, A. Goldschmidt, K. Mase, Abdul Rehman, David Kappesser, Kurt Woschnagg, Paul Evenson, Clara E. Hill, Le Viet Nguyen, Sebastian Sanchez Herrera, Marcos Santander, Carsten Rott, L. Gerhardt, Y. Popovych, J. Evans, Maria Tselengidou, D. Soldin, J. B. Tjus, Chiara Bellenghi, Alexander A. Harnisch, Benjamin Bastian, Anastasia Maria Barbano, Markus Ackermann, S. W. Barwick, Matti Jansson, Immacolata Carmen Rea, P. Eller, Simone Garrappa, H. Schieler, Dmitry Chirkin, Kael Hanson, A. Kyriacou, A. Olivas, Hermann Kolanoski, Simeon Reusch, A. O. Pollmann, Elisa Bernardini, K. Meagher, S. Hickford, J. C. Gallagher, Kirill Filimonov, Mehmet Gunduz, Agnieszka Leszczyńska, R. C. Bay, Alexander Kappes, Pranav Dave, Jan Soedingrekso, K. Krings, Xianwu Xu, J. Sandroos, James Madsen, Lu Lu, M. J. Weiss, Stef Verpoest, H. Dujmovic, Austin Schneider, Juan Carlos Diaz-Velez, Jenni Adams, K.-H. Becker, Yiqian Xu, M. Plum, A. Wallace, Katharina Morik, J. Stettner, Daniel Bindig, Ramesh Koirala, Gerrit Wrede, C.P. de los Heros, Thomas Huber, Ek Narayan Paudel, Allan Hallgren, Matt Dunkman, R. Joppe, T. Stezelberger, Colin Turley, S. Kopper, Christian Glaser, Paolo Desiati, S. Sarker, C. Alispach, Damian Pieloth, R. G. Stokstad, Ali Kheirandish, Sreetama Goswami, Minjin Jeong, Martin Ha Minh, T. Glüsenkamp, Janet Conrad, G. Krückl, Jannis Necker, Sebastian Baur, R. Cross, Sebastian Fiedlschuster, Surujhdeo Seunarine, Ken'ichi Kin, Jannes Brostean-Kaiser, Chunfai Tung, Alejandro Diaz, M. J. Larson, M. U. Nisa, Tim Ruhe, E. O'Sullivan, René Reimann, Chad Finley, Federica Bradascio, A. V. Balagopal, Alexander Burgman, M. Meier, Michael Campana, F. Huang, Christoph Tönnis, Benjamin Hokanson-Fasig, E. Blaufuss, Leander Fischer, Gerrit Roellinghoff, Mirco Hunnefeld, Marie Oehler, Thomas Stuttard, William Luszczak, G. H. Collin, Sarah Pieper, Dirk Ryckbosch, S. Robertson, R. Snihur, A. Ludwig, Wing Yan Ma, Yang Lyu, Grant Parker, L. Köpke, Karl J. Clark, Juanan Aguilar, I. Safa, Merlin Schaufel, James DeLaunay, Marjon Moulai, Olga Botner, Cristian Jesus Lozano Mariscal, Kendall Mahn, L. Classen, Johan Wulff, K. Wiebe, Timothyblake Watson, J. J. Beatty, Tianlu Yuan, Stephan Meighen-Berger, S. Yoshida, Kayla Leonard, A. Ishihara, V. Baum, H. Niederhausen, Won Nam Kang, Joshua Hignight, A. Sharma, Sukeerthi Dharani, Francis Halzen, J. Merz, Paras Koundal, Mike Richman, X. Bai, Konstancja Satalecka, F. McNally, Emma C. Hettinger, I. Ansseau, Michael Kovacevich, Theo Glauch, Juliana Stachurska, H. Dembinski, Reina H. Maruyama, Frank G. Schröder, Summer Blot, Thomas Ehrhardt, D. Tosi, D. van Eijk, Mark Weyrauch, Spencer Axani, Elisa Lohfink, Aaron Fienberg, Amirreza Raissi, S. Tilav, Michael DuVernois, Carlos Arguelles, Jessie Micallef, Stephanie Bron, R. S. Busse, Y. L. Li, J. P. Yanez, Gerald Przybylski, Christian Haack, Christopher Wiebusch, R. Halliday, Kunal Deoskar, K. Helbing, Alexander Sandrock, N. Kurahashi, Todor Stanev, Benedikt Riedel, Cristina Lagunas Gualda, C. Wendt, G. W. Sullivan, A. Karle, James E. Braun, Philipp Furst, D. Hebecker, G. de Wasseige, George Japaridze, Roger Moore, Paul Coppin, Andrea Turcati, T. Gregoire, J. van Santen, R. Hoffmann, Alex Pizzuto, Gary Binder, J. Bourbeau, Richard Naab, Zhedong Zhang, C. Walck, Thomas K. Gaisser, Ava Ghadimi, Franziska Tischbein, Seongjin In, Elisa Resconi, Alessio Porcelli, P. Mallik, Catherine De Clercq, M. Rongen, Qinrui Liu, Martina Karl, Jochen M. Schneider, Christian Spiering, Justin Vandenbroucke, Maria Prado Rodriguez, Abhishek Desai, Xinyue Kang, Claudio Kopper, S. C. Nowicki, Subir Sarkar, T. Kintscher, Frederik Hermann Lauber, Justin Lanfranchi, David Vannerom, Ben Smithers, Jean Pierre Twagirayezu, A. Haungs, Rui An, Nahee Park, K. Hultqvist, Darren Grant, T. Stürwald, Z. Griffith, Felix Henningsen, A. R. Fazely, Simona Toscano, J. L. Kelley, Markus Ahlers, Erik Ganster, Samvel Ter-Antonyan, Rasha Abbasi, B. J. Whelan, Jan Weldert, L. Halve, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, Elementary Particle Physics, and collaboration, The IceCube
Subjects: FOS: Computer and information sciences, Computer Science - Machine Learning, Astrophysics::High Energy Astrophysical Phenomena, cs.LG, Data analysis, FOS: Physical sciences, Fitting methods, 01 natural sciences, Convolutional neural network, Calibration, Cluster finding, Neutrino detectors, Pattern recognition, High Energy Physics - Experiment, IceCube Neutrino Observatory, Machine Learning (cs.LG), High Energy Physics - Experiment (hep-ex), 0103 physical sciences, 010303 astronomy & astrophysics, Instrumentation, Mathematical Physics, 010308 nuclear & particles physics, business.industry, hep-ex, Deep learning, Detector, Neutrino detector, Computer engineering, Orders of magnitude (time), 13. Climate action, Cascade, Pattern recognition (psychology), Artificial intelligence, business
Abstract: Continued improvements on existing reconstruction methods are vital to the success of high-energy physics experiments, such as the IceCube Neutrino Observatory. In IceCube, further challenges arise as the detector is situated at the geographic South Pole where computational resources are limited. However, to perform real-time analyses and to issue alerts to telescopes around the world, powerful and fast reconstruction methods are desired. Deep neural networks can be extremely powerful, and their usage is computationally inexpensive once the networks are trained. These characteristics make a deep learning-based approach an excellent candidate for the application in IceCube. A reconstruction method based on convolutional architectures and hexagonally shaped kernels is presented. The presented method is robust towards systematic uncertainties in the simulation and has been tested on experimental data. In comparison to standard reconstruction methods in IceCube, it can improve upon the reconstruction accuracy, while reducing the time necessary to run the reconstruction by two to three orders of magnitude., Comment: 39 pages, 15 figures, submitted to Journal of Instrumentation; added references
Published: 2021

29. Prevalence and Risk Factors of Diabetes Mellitus in β-thalassemia Major Patients in the North of Iran: Mazandaran β-thalassemia Registry - 2017 to 2019

Author: Mohammad Ghorbani, Mahdie Darvish-Khezri, Ali Kheirandish, Amirhossein Hessami, Ali Ahmadi, Hadi Darvishi-Khezri, Farzane Falegari, Hossein Karami, Mahdi Abounoori, Mohammad Zahedi, Zahra Alikhani, and Parham Mortazavi
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Thalassemia, Diabetes mellitus, medicine, business, medicine.disease, β thalassemia major
Abstract: Introduction: Thalassemia is a hereditary hemolytic disease spread throughout India, Arabian Peninsula, Iran, Turkey, and Southeast Asia. Diabetes mellitus (DM) is a common complication of patients with β-thalassemia major (β-TM) due to iron sediment in the pancreas. The purpose of this study was to survey the prevalence of DM in patients with β-TM. Material and Methods: Demographic, clinical information, and some biological tests in conjunction with the proportion of T2DM were retrieved from the Mazandaran Thalassemia Registry (MTR) affiliated to the Mazandaran University of Medical Science. The data belong to December 2017 until December 2019. Results: The results are as follows: Use of iron chelators like deferiprone should be with caution and with respect to the patients' metabolic state to avoid complications like diabetes. 2024 ꞵ-TM patients have registered in MTR (Mazandaran Thalassemia Registration). Data were completed for 597 cases including 72 patients (12.1%) diabetic and 525 patients (87.9%) non-diabetic. Beta-thalassemia patients with DM were significantly older than non-diabetic patients. Also, the percentage of ꞵ -TM cases dependent on red cell transfusion and patients with a history of spleen surgery in the diabetic group was significantly higher than in the non-diabetic group. Also, (42.7%) of diabetic patients (34 patients) were treated with insulin.Conclusion: We concluded that the history of splenectomy and the number of blood transfusions was higher in the diabetic group and associated with it. Future therapeutic approaches need to focus on reducing splenectomy and a high number of blood injections to avoid diabetes, and its complications in TM patients need to be investigated in future researches.
Published: 2021
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30. High-Energy Neutrinos from Magnetized Coronae of Active Galactic Nuclei and Prospects for Identification of Seyfert Galaxies and Quasars in Neutrino Telescopes

Author: Shigeo S. Kimura, Kohta Murase, and Ali Kheirandish
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Supermassive black hole, Active galactic nucleus, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, Quasar, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Galaxy, High Energy Physics - Phenomenology, KM3NeT, High Energy Physics - Phenomenology (hep-ph), Neutrino detector, Space and Planetary Science, Sky, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics, media_common
Abstract: Particles may be accelerated in magnetized coronae via magnetic reconnections and/or plasma turbulence, leading to high-energy neutrinos and soft gamma rays. We evaluate the detectability of neutrinos from nearby bright Seyfert galaxies identified by X-ray measurements. In the disk-corona model, we find that NGC 1068 is the most promising Seyfert galaxy in the Northern sky, where IceCube is the most sensitive, and show prospects for the identification of aggregated neutrino signals from Seyfert galaxies bright in X-rays. Moreover, we demonstrate that nearby Seyfert galaxies are promising targets for the next generation of neutrino telescopes such as KM3NeT and IceCube-Gen2. For KM3NeT, Cen A can be the most promising source in the Southern sky if a significant fraction of the observed X-rays come from the corona, and it could be identified in few years of KM3NeT operation. Our results reinforce the idea that hidden cores of supermassive black holes are the dominant sources of the high-energy neutrino emission and underlines the necessity of better sensitivity to medium-energy ranges in future neutrino detectors for identifying the origin of high-energy cosmic neutrinos., Comment: 23 pages, 16 figures, accepted for publication in ApJ. Discussion is extended, results and conclusions remain unchanged
Published: 2021
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31. Dynamic Antibody Response: a Biomarker for COVID-19

Author: Tooba Mohammadi, Ali Kheirandish, Amene Saghazadeh, Mehdi Mohebalizadeh, Nima Rezaei, and Mahsa Golshani Nasab
Subjects: biology, medicine.drug_class, business.industry, medicine.medical_treatment, COVID-19, Context (language use), Immunotherapy, Antibodies, Viral, Severe Acute Respiratory Syndrome, Monoclonal antibody, Antibodies, Neutralizing, General Biochemistry, Genetics and Molecular Biology, Virus, Vaccination, Immune system, Immunology, medicine, biology.protein, Humans, Biomarker (medicine), Antibody, business, Biomarkers
Abstract: Background Novel coronavirus disease 2019 (COVID-19) is the cause of the third pneumonia-like outbreak of coronaviruses in humans during the 21st century. The status of the host immune system is a critical factor that affects the severity and outcomes of COVID-19. In particular, antibody responses are an indicator of the anti-viral defense; so, a delayed or inappropriate induction of these responses would correlate with a defect in the viral clearance. Methods This is a rapid synthesis of literature investigating antibody responses in patients with the severe acute respiratory syndrome (SARS) and COVID-19. Results Lessons learned from severe acute respiratory syndrome (SARS), along with the direct evidence of antibody responses in COVID-19, pose the potentials of dynamic antibody responses for screening and prognostic purposes in COVID-19. Also, neutralizing antibodies extracted from recovered patients and monoclonal antibodies targeting cytokines offer therapeutic support for COVID-19. Conclusions Altogether, the dynamics of antibody responses help to determine the effectiveness of treatments for COVID-19. Of note, it might be helpful for the evaluation of the efficacy of immunotherapy and vaccination - the dreams for the future of COVID-19. Further studies are necessary to investigate the possibility and efficacy of antibody extraction from animal subjects. Finally, numerous factors affect antibody response such as race, nutrition status, and virus mutations in viral infections, which need to be considered in the context of COVID-19.
Published: 2021
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32. Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting

Author: Melika Arab Bafrani, Alireza Soltani Khaboushan, Marzieh Pirzadeh, Nima Rezaei, Amene Saghazadeh, Ali Kheirandish, Hanie Yavarpour_Bali, Amirhossein Hessami, and Sourena Sharifkashani
Subjects: 0301 basic medicine, medicine.medical_treatment, Pneumonia, Viral, ACE2, Plasma protein binding, Pharmacology, Peptidyl-Dipeptidase A, medicine.disease_cause, Virus, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Origin, Full Length Article, Drug Discovery, medicine, Humans, Transmission, Receptor, Pandemics, Coronavirus, chemistry.chemical_classification, Protease, Chemistry, Drug discovery, SARS-CoV-2, COVID-19, Virus Internalization, 030104 developmental biology, Enzyme, Angiotensin-converting enzyme 2, Spike Glycoprotein, Coronavirus, SARS-CoV2, Receptors, Virus, Angiotensin-Converting Enzyme 2, Therapeutic, Coronavirus Infections, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists, Protein Binding
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that uses the human angiotensin-converting enzyme 2 (ACE2) receptor as a point of entry. The present review discusses the origin and structure of the virus and its mechanism of cell entry followed by the therapeutic potentials of strategies directed towards SARS-CoV2-ACE2 binding, the renin-angiotensin system, and the kinin-kallikrein system. SARS-CoV2-ACE2 binding-directed approaches mainly consist of targeting receptor binding domain, ACE2 blockers, soluble ACE2, and host protease inhibitors. In conclusion, blocking or manipulating the SARS-CoV2-ACE2 binding interface perhaps offers the best tactic against the virus that should be treated as a fundamental subject of future research.
Published: 2020
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33. EV-Scale Sterile Neutrino Search Using Eight Years of Atmospheric Muon Neutrino Data from the IceCube Neutrino Observatory

Author: K. Tollefson, Albrecht Karle, U. Katz, R. S. Busse, G. H. Collin, Christopher Wiebusch, Kunal Deoskar, Thomas Ehrhardt, P. Schlunder, R. Hellauer, Spencer Axani, D. B. Fox, Kayla Leonard, R. Maunu, Alan Coleman, Sukeerthi Dharani, Francis Halzen, J. Merz, S. Hickford, R. Joppe, A. Wallace, Delia Tosi, Sebastian Baur, M. G. Aartsen, Carlos Arguelles, David Vannerom, I. Ansseau, Hermann Kolanoski, Juliana Stachurska, H. Dembinski, Stef Verpoest, Jessie Micallef, Matthias Vraeghe, George Japaridze, Roger Moore, Tim Ruhe, N. Kurahashi, Todor Stanev, C. Wendt, Ioana Codrina Maris, H. Bagherpour, Johan Wulff, Sebastian Böser, Olga Botner, J. Kim, Elisa Bernardini, A. Ludwig, Christoph Raab, Nadège Iovine, Timothyblake Watson, D. Heereman, Gisela Anton, M. Stamatikos, J. Bourbeau, K. Rawlins, G. de Wasseige, Won Nam Kang, V. Baum, Jenni Adams, D. Berley, G. C. Hill, H. Niederhausen, A. Steuer, C. Alispach, Bunheng Ty, Stephen L. Hauser, Raamis Hussain, Janet Conrad, B. Relethford, Jan Soedingrekso, Ralph Engel, Moritz Kellermann, Z. Griffith, Y. Makino, Seongjin In, R. Hoffmann, James Madsen, Konstancja Satalecka, Benjamin Bastian, Theo Glauch, Anastasia Maria Barbano, Saskia Philippen, F. Jonske, R. Cross, M. J. Larson, Lu Lu, T. Kittler, X. Bai, G. Neer, Alexander Fritz, A. Goldschmidt, D. van Eijk, Lenka Tomankova, Giovanni Renzi, D. Seckel, S. Fahey, Elisa Resconi, Alessio Porcelli, Claudio Kopper, Daniel Bindig, G. Krückl, Alejandro Diaz, C. Pérez de los Heros, E. O’Sullivan, Le Viet Nguyen, Wing Yan Ma, James DeLaunay, Marjon Moulai, R. G. Stokstad, K. Krings, M. Plum, P. B. Price, William Luszczak, M. Kauer, Suyong Choi, David Kappesser, S. E. Sanchez Herrera, Francesco Lucarelli, T. O. B. Schmidt, Tyce DeYoung, Chad Finley, Nathan Whitehorn, Immacolata Carmen Rea, Matti Jansson, D. Z. Besson, C. Walck, Thomas K. Gaisser, G. B. Yodh, A. Kyriacou, M. Silva, Najia Moureen Binte Amin, K.-H. Becker, Yiqian Xu, Qinrui Liu, J. Becker Tjus, T. Glüsenkamp, Subir Sarkar, Martina Karl, Matt Dunkman, Kendall Mahn, Christoph Tönnis, F. Huang, K. Meagher, Jochen M. Schneider, J. Stettner, T. R. Wood, Kurt Woschnagg, Paul Evenson, T. Palczewski, S. De Ridder, Y. L. Li, G. W. Sullivan, J. J. Beatty, Tianlu Yuan, Jeffrey Lazar, Chunfai Tung, James E. Braun, Alexander Trettin, E. Cheung, J. Werthebach, Thomas Stuttard, Mirco Hunnefeld, Marie Oehler, Alexander Sandrock, Elisa Lohfink, Thomas Meures, N. L. Strotjohann, M. A. Unland Elorrieta, M. Wallraff, Michael DuVernois, Benjamin Hokanson-Fasig, Felix Henningsen, Karl J. Clark, Simone Garrappa, Dmitry Chirkin, Sarah Pieper, D. Hebecker, Anatoli Fedynitch, K. Helbing, Chujie Chen, Dirk Ryckbosch, Joshua Hignight, M. Zöcklein, T. Grégoire, Timo Sturwald, J. C. Gallagher, Timo Karg, Gerald Przybylski, Federica Bradascio, Yang Lyu, Alexander Kappes, Alexander Burgman, M. Song, T. L. Carver, Paras Koundal, Mike Richman, Sarah Mancina, Paul Coppin, Anna Franckowiak, Tobias Hoinka, Vedant Basu, Steve Sclafani, F. McNally, A. R. Fazely, M. Usner, Grant Parker, R. Halliday, Stephan Meighen-Berger, K. D. de Vries, Gerrit Wrede, Andrea Turcati, J. van Santen, K. Hoshina, Glenn Spiczak, Thomas Huber, G. Momenté, Merlin Schaufel, A. Stößl, J. Kiryluk, K. Andeen, D. R. Nygren, Marek Kowalski, A. Weindl, Maryon Ahrens, Frederik Tenholt, R. Nagai, M. Medici, M. Rameez, Javier Gonzalez, Roxanne Turcotte, Alex Pizzuto, D. F. Cowen, Reina H. Maruyama, E. Pinat, N. Kulacz, U. Naumann, Martin Rongen, Ek Narayan Paudel, Allan Hallgren, Giorgio Maggi, K. Wiebe, A. Balagopal, Gary Binder, Zhedong Zhang, E. Unger, Simona Toscano, J. Auffenberg, Pablo Correa, Summer Blot, Brian Clark, C. De Clercq, P. Heix, K. Mase, P. Mallik, M. E. Huber, A. O'Murchadha, Marcos Santander, Ramesh Koirala, David A. Williams, L. Schumacher, Benedikt Riedel, S. Tilav, Max Renschler, D. Kang, D. J. Koskinen, Markus Ackermann, S. W. Barwick, L. Gerhardt, M. J. Weiss, E. Bourbeau, J. P. Yanez, Ben Smithers, Colin Turley, A. Olivas, S. Kopper, Spencer Griswold, I. Taboada, Michael O. Wolf, René Reimann, A. Haungs, M. Prado Rodriguez, Maria Tselengidou, D. Soldin, Nahee Park, Pranav Dave, K. Hultqvist, Darren Grant, E. Blaufuss, Mehmet Gunduz, Agnieszka Leszczyńska, R. C. Bay, M. Günder, Austin Schneider, Steven Robertson, Juan Carlos Diaz-Velez, Shefali Shefali, L. Classen, T. Stezelberger, Abdul Rehman, Carsten Rott, Y. Popovych, T. Kintscher, Frederik Hermann Lauber, Xianwu Xu, A. Terliuk, J. Sandroos, C. Bohm, Justin Lanfranchi, Christian Spiering, Justin Vandenbroucke, Abhishek Desai, S. C. Nowicki, Rasha Abbasi, B. J. Whelan, Jan Weldert, L. Halve, Philipp Eller, J. Felde, J. Buscher, D. Rysewyk Cantu, A. Obertacke Pollmann, J. L. Kelley, Markus Ahlers, Erik Ganster, Samvel Ter-Antonyan, Frank G. Schröder, J. Lünemann, N. van Eijndhoven, C. Haack, Emily Dvorak, Aaron Fienberg, Amirreza Raissi, Minjin Jeong, Chris Weaver, Stephanie Bron, C. J. Lozano Mariscal, H. Dujmovic, L. Rauch, S. Yoshida, Surujhdeo Seunarine, R. Snihur, Juanan Aguilar, Kael Hanson, A. Ishihara, Maximilian Meier, Paolo Desiati, Segev BenZvi, Spencer Klein, B. J. P. Jones, Andres Medina, Kara Hoffman, D. Mockler, Hershal Pandya, Daria Pankova, E. Friedman, Wolfgang Rhode, Robert Stein, L. Wills, P. Muth, R. Morse, Jakob Bottcher, T. Montaruli, Maximilian Karl Scharf, P. Peiffer, Ibrahim Safa, Damian Pieloth, Ali Kheirandish, W. Van Driessche, Jannes Brostean-Kaiser, M. U. Nisa, L. Köpke, T. Anderson, John Hardin, H. Schieler, Kirill Filimonov, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Elementary Particle Physics
Subjects: Sterile neutrino, Physics::Instrumentation and Detectors, General Physics and Astronomy, sterile [neutrino], 01 natural sciences, Cosmology, IceCube, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Astronomi, astrofysik och kosmologi, Subatomic Physics, TOOL, Astronomy, Astrophysics and Cosmology, atmosphere [muon], Muon neutrino, Physics, oscillation [neutrino], Astrophysics::Instrumentation and Methods for Astrophysics, hep-ph, neutrino: sterile, mass difference [neutrino], ddc, muon: atmosphere, observatory, High Energy Physics - Phenomenology, Physique des particules élémentaires, signature, Particle physics, data analysis method, Scale (ratio), Astrophysics::High Energy Astrophysical Phenomena, neutrino: mass difference, FOS: Physical sciences, IceCube Neutrino Observatory, statistical analysis, 0103 physical sciences, OSCILLATIONS, ddc:530, 010306 general physics, hep-ex, ICE, High Energy Physics::Phenomenology, neutrino: mixing angle, CONVERSION, Physics and Astronomy, COSMOLOGY, High Energy Physics::Experiment, neutrino: oscillation, BAYESIAN-INFERENCE, mixing angle [neutrino], experimental results
Abstract: Physical review letters 125(14), 141801 (1-11) (2020). doi:10.1103/PhysRevLett.125.141801, The results of a 3+1 sterile neutrino search using eight years of data from the IceCube Neutrino Observatory are presented. A total of 305 735 muon neutrino events are analyzed in reconstructed energy-zenith space to test for signatures of a matter-enhanced oscillation that would occur given a sterile neutrino state with a mass-squared differences between 0.01 and 100 eV$^2$. The best-fit point is found to be at sin$^2$($2θ_{24}$)=0.10 and $Δm_{41}^2$=4.5 eV$^2$, which is consistent with the no sterile neutrino hypothesis with a $p$ value of 8.0%., Published by APS, College Park, Md.
Published: 2020
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34. IceCube-Gen2: The Window to the Extreme Universe

Author: J. Kim, A. Gartner, A. Obertacke Pollmann, B. Hoffmann, J. L. Kelley, Markus Ahlers, Jenni Adams, Akimichi Taketa, D. van Eijk, Daniel Bindig, G. H. Collin, T. C. Arlen, Robert Lahmann, J. J. Beatty, Tianlu Yuan, U. Nauman, Azadeh Keivani, Y. L. Li, Karl J. Clark, T. Kintscher, M. Song, T. L. Carver, Paras Koundal, Michael Kovacevich, Christian Glaser, Frederik Hermann Lauber, T. Huege, Erik Ganster, Benedikt Riedel, D. Seckel, Anna Nelles, R. G. Stokstad, F. McNally, R. Maunu, M. Prado Rodriguez, Kayla Leonard, N. Kurahashi, James E. Braun, Amy Connolly, Samvel Ter-Antonyan, A. Terliuk, Justin Lanfranchi, Pranav Dave, Jannis Necker, C. Wendt, S. Wren, A. Sharma, Sukeerthi Dharani, David Vannerom, M. H. Shaevitz, Alexander Trettin, Reina H. Maruyama, Francis Halzen, J. Merz, K. Krings, Rasha Abbasi, Ben Smithers, Qinrui Liu, M. J. Larson, T. Anderson, Summer Blot, G. de Wasseige, I. Ansseau, D. Hebecker, Jorge Torres, Killian Holzapfel, Martina Karl, C. J. Lozano Mariscal, John Hardin, Jean Pierre Twagirayezu, Daniel García-Fernández, T. Stezelberger, S. Mandalia, E. O'Sullivan, R. Hoffmann, M. Plum, Juliana Stachurska, H. Dembinski, C. Pérez de los Heros, S. Márka, G. WSullivan, A. Haungs, Paul Coppin, Z. Griffith, J. C. Gallagher, Saskia Philippen, Federica Bradascio, Jochen M. Schneider, Srubabati Goswami, Andrea Turcati, Wing Yan Ma, Nahee Park, Y. Makino, Sarah Mancina, C. Walck, M. Kauer, Suyong Choi, Anna Franckowiak, Tobias Hoinka, Chad Finley, David Kappesser, T. Gregoire, Ella Roberts, J. van Santen, S. De Ridder, Jan Weldert, Chunfai Tung, F. Jonske, Ken'ichi Kin, L. Halve, Philipp Eller, K. Hultqvist, N. L. Strotjohann, H. Dujmovic, Vedant Basu, M. A. Unland Elorrieta, Alex Pizzuto, K. D. de Vries, I. CMariş, Gerrit Wrede, R. Gernhaeuser, Thomas Huber, Matti Jansson, Thomas K. Gaisser, M. Richman, Christoph Tönnis, James DeLaunay, Gary Binder, K.-H. Becker, Ek Narayan Paudel, Allan Hallgren, U. Latif, Hiroyuki Tanaka, I. Safa, Steve Sclafani, J. Kiryluk, K. Andeen, P. B. Price, H. Schieler, Kirill Filimonov, Segev BenZvi, Alexander Fritz, D. Z. Besson, Darren Grant, Marjon Moulai, Yiqian Xu, Felix Henningsen, S. Robertson, Aswathi Balagopal, Francesco Lucarelli, Pisin Chen, Matt Dunkman, Merlin Schaufel, Patrick Allison, Spencer Klein, Cosmin Deaconu, Tim Ruhe, A. Ludwig, George Japaridze, Javier Gonzalez, C. B. Krauss, Roxanne Turcotte, T. O. B. Schmidt, Simona Toscano, Roger Moore, P. Heix, R. S. Busse, Chujie Chen, Pablo Correa, L. Gerhard, S. De Kockere, J. Felde, Surujhdeo Seunarine, R. Snihur, J. Buscher, D. Rysewyk Cantu, A. Weindl, R. Hellauer, Giorgio Maggi, H. Niederhausen, Mauricio Bustamante, D. Southall, Julia Böttcher, J. Bourbeau, Lenka Tomankova, Maryon Ahrens, A. Burgman, Christopher Wiebusch, Darko Veberič, Juanan Aguilar, T. R. Wood, Christian Spiering, Frederik Tenholt, R. Nagai, L. Schumacher, C. De Clercq, Benjamin Hokanson-Fasig, L. V. Nguyen, C. Lagunas Gualda, K. Hughes, Kara Hoffman, C. Alispach, J. M. LoSecco, Joshua Hignight, K. Helbing, Timo Sturwald, Xinyue Kang, Richard Naab, Kunal Deoskar, Janet Conrad, Zackary Meyers, K. Meagher, Mehmet Gunduz, Agnieszka Leszczyńska, R. C. Bay, David A. Williams, Kurt Woschnagg, M. Zöcklein, M. Silva, Claudio Kopper, Eric Oberla, Ramesh Koirala, E. Cheung, Thomas Stuttard, Martin Rongen, Najia Moureen Binte Amin, R. Cross, Paul Evenson, A. Karle, Sebastian Böser, Seongjin In, Johannes Werthebach, J. P. Lazar, Markus Ackermann, Austin Schneider, Yang Lyu, Justin Vandenbroucke, Juan Carlos Diaz-Velez, Beverley A. Clark, Timo Karg, Sarah Pieper, Hershal Pandya, Wolfgang Rhode, Zhedong Zhang, P. Schlunder, A. Ishihara, Elisa Resconi, Subir Sarkar, William Luszczak, Clara E. Hill, Ava Ghadimi, Alessio Porcelli, Alan Coleman, J. Auffenberg, Grant Parker, Robert Stein, Dirk Ryckbosch, Benjamin Bastian, Anastasia Maria Barbano, Abhishek Desai, T. Kittler, J. Nam, P. Mallik, E. Blaufuss, S. Zierke, T. Stanev, M. Bohmer, Stephan Meighen-Berger, Simone Garrappa, P. Muth, Dmitry Chirkin, M. E. Huber, Marcos Santander, Christoph Raab, Nadège Iovine, J. Becker Tjus, L. Classen, Colin Turley, S. C. Nowicki, K. Farrag, M. Kleifges, O. Kalekin, A. Olivas, Alexander Kappes, D. Berley, G. C. Hill, Abigail G. Vieregg, Frank G. Schröder, D. Heinen, Erin Carnie-Bronca, N. Kulacz, D. Tosi, J. C. Hanson, Bunheng Ty, Ralph Engel, Moritz Kellermann, Gisela Anton, Elisa Lohfink, Elisa Bernardini, Damian Pieloth, Ali Kheirandish, Jan Soedingrekso, Giovanni Renzi, Michael DuVernois, Jannes Brostean-Kaiser, K. Wiebe, S. Fahey, A. R. Fazely, Tyce DeYoung, J. Lünemann, Thomas Ehrhardt, Nathan Whitehorn, Immacolata Carmen Rea, M. U. Nisa, Aaron Fienberg, Gerald Przybylski, G. Krückl, L. Papp, Amirreza Raissi, L. Köpke, Chris Weaver, R. Halliday, Alejandro Diaz, Stephanie Bron, S. Söldner-Rembold, James Pinfold, Ryan Burley, M. Riegel, H. Bagherpour, Stephanie Wissel, Olga Botner, Y. Pan, A. Steuer, S. Tilav, D. Kang, M. deWith, V. Baum, J. P. Yanez, I. Taboada, Stephen L. Hauser, Raamis Hussain, Michael O. Wolf, M. Stamatikos, John Evans, Shefali Shefali, Christoph Welling, Abdul Rehman, Carsten Rott, K. Tollefson, A. Goldschmidt, Y. Popovych, Troels Petersen, S. E. Sanchez Herrera, Simeon Reusch, S. Hickford, Xianwu Xu, J. Sandroos, C. Bohm, R. Joppe, Spencer Axani, Sebastian Baur, Carlos Arguelles, Jessie Micallef, Teppei Katori, K. Rawlins, James Madsen, Lu Lu, M. G. Aartsen, T. Glüsenkamp, M. Meier, Michael Campana, P. Sandstrom, Kendall Mahn, B. J. P. Jones, K. Hoshina, Glenn Spiczak, Andres Medina, G. Momenté, D. Mockler, M. Rameez, D. F. Cowen, Daria Pankova, E. Friedman, R. Morse, T. Montaruli, E. Unger, Maximilian Karl Scharf, P. Peiffer, J. Stettner, Gerrit Roellinghoff, Mirco Hunnefeld, Marie Oehler, Max Renschler, D. J. Koskinen, E. Bourbeau, Spencer Griswold, Maria Tselengidou, D. Soldin, Z. Márka, Minjin Jeong, L. Rauch, S. Yoshida, N. van Eijndhoven, C. Haack, Emily Dvorak, D. R. Nygren, Marek Kowalski, Kael Hanson, Paolo Desiati, J. Haugen, Lars Steffen Weinstock, Johan Wulff, Won Nam Kang, Timothyblake Watson, X. Bai, G. Neer, Konstancja Satalecka, Theo Glauch, U. Katz, Alexander Sandrock, Ilse Plaisier, K. Mase, D. B. Fox, Hermann Kolanoski, M. J. Weiss, Stef Verpoest, Imre Bartos, David J. Smith, S. Kopper, René Reimann, Leander Fischer, F. Huang, Matthias Vraeghe, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Elementary Particle Physics
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Nuclear and High Energy Physics, Active galactic nucleus, 010308 nuclear & particles physics, High-energy astronomy, Gravitational wave, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, FOS: Physical sciences, Cosmic ray, 01 natural sciences, Universe, Neutron star, 0103 physical sciences, Neutrino, Neutrino astronomy, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics, media_common
Abstract: The observation of electromagnetic radiation from radio to $\gamma$-ray wavelengths has provided a wealth of information about the universe. However, at PeV (10$^{15}$ eV) energies and above, most of the universe is impenetrable to photons. New messengers, namely cosmic neutrinos, are needed to explore the most extreme environments of the universe where black holes, neutron stars, and stellar explosions transform gravitational energy into non-thermal cosmic rays. The discovery of cosmic neutrinos with IceCube has opened this new window on the universe. In this white paper, we present an overview of a next-generation instrument, IceCube-Gen2, which will sharpen our understanding of the processes and environments that govern the universe at the highest energies. IceCube-Gen2 is designed to: 1) Resolve the high-energy neutrino sky from TeV to EeV energies; 2) Investigate cosmic particle acceleration through multi-messenger observations; 3) Reveal the sources and propagation of the highest energy particles in the universe; 4) Probe fundamental physics with high-energy neutrinos. IceCube-Gen2 will increase the annual rate of observed cosmic neutrinos by a factor of ten compared to IceCube, and will be able to detect sources five times fainter than its predecessor. Furthermore, through the addition of a radio array, IceCube-Gen2 will extend the energy range by several orders of magnitude compared to IceCube. Construction will take 8 years and cost about \$350M. The goal is to have IceCube-Gen2 fully operational by 2033. IceCube-Gen2 will play an essential role in shaping the new era of multi-messenger astronomy, fundamentally advancing our knowledge of the high-energy universe. This challenging mission can be fully addressed only in concert with the new survey instruments across the electromagnetic spectrum and gravitational wave detectors which will be available in the coming years., Comment: 56 pages, 29 figures
Published: 2020
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35. IceCube Search for High-Energy Neutrino Emission from TeV Pulsar Wind Nebulae

Author: C. Haack, Immacolata Carmen Rea, Emily Dvorak, K.-H. Becker, K. Hoshina, Yiqian Xu, Matt Dunkman, K. Mase, Yuya Makino, Minjin Jeong, Timothyblake Watson, Thomas Meures, B. Relethford, E. Cheung, Saskia Philippen, M. J. Weiss, Konstancja Satalecka, Theo Glauch, L. Rauch, U. Katz, Thomas Stuttard, S. De Ridder, Jeffrey Lazar, P. B. Price, D. Heereman, S. Yoshida, D. B. Fox, S. Kopper, Sarah Pieper, K. Jero, N. L. Strotjohann, Hermann Kolanoski, Dirk Ryckbosch, Stef Verpoest, Colin Turley, Felix Henningsen, M. Zöcklein, René Reimann, C. Alispach, Lenka Tomankova, T. Grégoire, Timo Karg, A. Steuer, Stephan Meighen-Berger, Janet Conrad, Thomas Ehrhardt, Frank G. Schröder, A. R. Fazely, M. Silva, Francesco Lucarelli, Raamis Hussain, R. Cross, A. Obertacke Pollmann, E. Pinat, T. O. B. Schmidt, Johannes Werthebach, M. Usner, Kael Hanson, Karl J. Clark, Maximilian Meier, S. Hickford, R. Joppe, Delia Tosi, Sebastian Baur, Chujie Chen, A. Weindl, Maryon Ahrens, Frederik Tenholt, R. Nagai, K. Helbing, Won Nam Kang, X. Bai, G. Neer, Simona Toscano, P. Heix, R. Maunu, J. Lünemann, William Luszczak, S. Tilav, M. Medici, Christian Spiering, L. Wills, P. Muth, P. Schlunder, Daria Pankova, E. Friedman, R. S. Busse, M. Song, T. L. Carver, Mike Richman, Amirreza Raissi, Federica Bradascio, Alexander Burgman, T. R. Wood, Ramesh Koirala, J. P. Yanez, Karim Ghorbani, Spencer Axani, Christopher Wiebusch, Kunal Deoskar, Paolo Desiati, Chris Weaver, Stephanie Bron, Kurt Woschnagg, C. J. Lozano Mariscal, G. Merino, Tim Ruhe, Justin Vandenbroucke, H. Bagherpour, Alexander Sandrock, J. L. Kelley, Markus Ahlers, Martin Rongen, George Japaridze, Roger Moore, A. Ludwig, Olga Botner, Paul Evenson, M. G. Aartsen, N. Wandkowsky, H. Dujmovic, Merlin Schaufel, M. Stamatikos, E. Blaufuss, Ioana Codrina Maris, L. Wille, H. Niederhausen, Carlos Arguelles, Ibrahim Safa, V. Baum, Jessie Micallef, L. Classen, Damian Pieloth, Ali Kheirandish, N. Kurahashi, J. Bourbeau, D. Kang, Todor Stanev, K. Tollefson, Surujhdeo Seunarine, Albrecht Karle, D. van Eijk, Christoph Raab, Nadège Iovine, P. Mallik, Simone Garrappa, Dmitry Chirkin, S. C. Nowicki, W. Van Driessche, C. Wendt, Alexander Kappes, Erik Ganster, K. Mallot, R. Morse, James W. Wood, Z. Griffith, Jakob Bottcher, D. Berley, G. C. Hill, Bunheng Ty, R. Snihur, T. Montaruli, Jannes Brostean-Kaiser, Juanan Aguilar, G. de Wasseige, G. W. Sullivan, K. Rawlins, Donglian Xu, Seongjin In, B. J. P. Jones, Ralph Engel, Moritz Kellermann, Elisa Resconi, I. Taboada, Samvel Ter-Antonyan, Elisa Lohfink, James E. Braun, Gisela Anton, James Madsen, Lu Lu, Alessio Porcelli, T. Kintscher, Frederik Hermann Lauber, Giovanni Renzi, A. Goldschmidt, D. Hebecker, Qinrui Liu, R. Hoffmann, T. Glüsenkamp, Le Viet Nguyen, L. Köpke, D. Seckel, S. Fahey, Michael O. Wolf, Alexander Fritz, D. Z. Besson, Martina Karl, A. Wallace, A. Terliuk, Paul Coppin, Andrea Turcati, Justin Lanfranchi, J. van Santen, Mehr Nisa, Jochen M. Schneider, B. J. Whelan, Claudio Kopper, A. Ishihara, Tyce DeYoung, Andres Medina, Alexander Trettin, Nathan Whitehorn, Alex Pizzuto, D. R. Nygren, Gerald Przybylski, S. E. Sanchez Herrera, M. A. Unland Elorrieta, Gary Binder, R. Halliday, A. Haungs, C. Pérez de los Heros, K. Krings, D. Mockler, Nahee Park, K. Hultqvist, M. Wallraff, Darren Grant, Kendall Mahn, C. Walck, Alan Coleman, E. O’Sullivan, T. Anderson, Marek Kowalski, J. C. Gallagher, M. Plum, Subir Sarkar, Jan Weldert, Thomas K. Gaisser, G. B. Yodh, A. Kyriacou, Gerrit Wrede, K. Meagher, L. Halve, Philipp Eller, Thomas Huber, Allan Hallgren, Benjamin Hokanson-Fasig, Yang Lyu, Elisa Bernardini, J. Auffenberg, Chunfai Tung, J. Becker Tjus, J. Felde, J. Buscher, D. Rysewyk Cantu, Jenni Adams, P. Peiffer, Joshua Hignight, Timo Sturwald, H. Schieler, Kirill Filimonov, K. Wiebe, Steven Robertson, R. G. Stokstad, Segev BenZvi, Shefali Shefali, Spencer Klein, Abdul Rehman, Carsten Rott, Kara Hoffman, Javier Gonzalez, Roxanne Turcotte, Giorgio Maggi, Matthias Vraeghe, C. De Clercq, Hershal Pandya, Wolfgang Rhode, David A. Williams, Xianwu Xu, Robert Stein, J. Sandroos, Markus Ackermann, S. W. Barwick, C. Bohm, J. Kim, Daniel Bindig, K. D. de Vries, N. Kulacz, Brian Clark, Chad Finley, Christoph Tönnis, Pranav Dave, M. Günder, T. Stezelberger, G. H. Collin, Sarah Mancina, Anna Franckowiak, Tobias Hoinka, Kayla Leonard, Steve Sclafani, Jan Soedingrekso, Francis Halzen, J. Kiryluk, K. Andeen, I. Ansseau, G. Krückl, Juliana Stachurska, Alejandro Diaz, Pablo Correa, H. Dembinski, M. Kauer, Suyong Choi, David Kappesser, R. Hellauer, Matti Jansson, T. Palczewski, Sebastian Böser, Benjamin Bastian, Anastasia Maria Barbano, T. Kittler, B. Eberhardt, M. E. Huber, Marcos Santander, L. Gerhardt, A. Olivas, M. J. Larson, Wing Yan Ma, James DeLaunay, Marjon Moulai, J. J. Beatty, Tianlu Yuan, F. McNally, A. Stößl, Reina H. Maruyama, Summer Blot, F. Jonske, L. Schumacher, F. Huang, Mehmet Gunduz, Agnieszka Leszczyńska, R. C. Bay, Austin Schneider, Juan Carlos Diaz-Velez, Glenn Spiczak, G. Momenté, M. Rameez, D. F. Cowen, U. Naumann, E. Unger, A. O'Murchadha, Max Renschler, D. J. Koskinen, E. Bourbeau, Spencer Griswold, Maria Tselengidou, D. Soldin, J. Stettner, Mirco Hunnefeld, Marie Oehler, N. van Eijndhoven, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Elementary Particle Physics
Subjects: 010504 meteorology & atmospheric sciences, High-energy astronomy, Astrophysics::High Energy Astrophysical Phenomena, Neutrino astronomy, High energy astrophysics, FOS: Physical sciences, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, Pulsar, 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Astronomy and Astrophysics, Galactic plane, COSMIC-RAYS, CRAB-NEBULA, Crab Nebula, Physics and Astronomy, 13. Climate action, Space and Planetary Science, GALACTIC SOURCES, DISCOVERY, Physique des particules élémentaires, High Energy Physics::Experiment, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, GAMMA-RAY EMISSION, Lepton
Abstract: Pulsar wind nebulae (PWNe) are the main gamma-ray emitters in the Galactic plane. They are diffuse nebulae that emit nonthermal radiation. Pulsar winds, relativistic magnetized outflows from the central star, shocked in the ambient medium produce a multiwavelength emission from the radio through gamma-rays. Although the leptonic scenario is able to explain most PWNe emission, a hadronic contribution cannot be excluded. A possible hadronic contribution to the high-energy gamma-ray emission inevitably leads to the production of neutrinos. Using 9.5 yr of all-sky IceCube data, we report results from a stacking analysis to search for neutrino emission from 35 PWNe that are high-energy gamma-ray emitters. In the absence of any significant correlation, we set upper limits on the total neutrino emission from those PWNe and constraints on hadronic spectral components., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2020
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36. Light curves of BSM-induced neutrino echoes in the optically thin limit

Author: Ryan Eskenasy, Ali Kheirandish, and Kohta Murase
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, FOS: Physical sciences, High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena
Abstract: High-energy neutrinos from astrophysical transients serve as a probe of neutrino physics beyond the Standard Model. In particular, nonstandard interaction of neutrinos with the cosmic neutrino background or dark matter (DM) may have imprints on not only their spectra but also the arrival and time-delay distributions. Assuming that the interaction occurs at most once during the neutrino propagation, we provide general analytic formulas for light curves of the neutrino echoes induced by BSM. The formulas can be used for constraining neutrino-neutrino scattering, neutrino-DM scattering, and other scattering processes experienced by relativistic particles., Comment: 9 pages, 6 figures, version published in PRD, minor changes
Published: 2020
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37. LeptonInjector and LeptonWeighter: A neutrino event generator and weighter for neutrino observatories

Author: Janet Conrad, R. Cross, D. Hebecker, William Luszczak, K.-H. Becker, Yiqian Xu, Matt Dunkman, Ioana Codrina Maris, Thomas Stuttard, Christian Spiering, Thomas Ehrhardt, Sarah Pieper, A. Kyriacou, Ken'ichi Kin, Christoph Raab, Nadège Iovine, Dirk Ryckbosch, S. De Ridder, Stephan Meighen-Berger, D. Berley, G. C. Hill, Bunheng Ty, Paul Coppin, Justin Vandenbroucke, Andrea Turcati, J. Becker Tjus, J. J. Beatty, Christian Haack, Tianlu Yuan, M. J. Larson, Ralph Engel, Moritz Kellermann, F. McNally, Wing Yan Ma, Emma C. Hettinger, Reina H. Maruyama, A. Obertacke Pollmann, Summer Blot, Frank G. Schröder, U. Katz, Giovanni Renzi, Damian Pieloth, Ali Kheirandish, T. Gregoire, James DeLaunay, Marjon Moulai, S. Fahey, M. Kauer, Tyce DeYoung, Abhishek Desai, J. Werthebach, D. B. Fox, J. van Santen, J. L. Kelley, Markus Ahlers, Suyong Choi, Alex Pizzuto, Jannes Brostean-Kaiser, Nathan Whitehorn, Immacolata Carmen Rea, David Kappesser, Jan Soedingrekso, Brandom Pries, L. Schumacher, Maximilian Karl Scharf, S. C. Nowicki, Gary Binder, Karl J. Clark, D. van Eijk, Shefali Shefali, P. B. Price, Matti Jansson, A. Franckowiak, Hermann Kolanoski, M. U. Nisa, Mehmet Gunduz, Agnieszka Leszczyńska, R. C. Bay, Abdul Rehman, Francesco Lucarelli, Carsten Rott, Chujie Chen, Austin Schneider, George Japaridze, Juan Carlos Diaz-Velez, Roger Moore, L. Köpke, Mark Weyrauch, Stef Verpoest, Aaron Fienberg, Timo Karg, D. Tosi, Y. L. Li, Amirreza Raissi, T. O. B. Schmidt, Paras Koundal, Mike Richman, N. van Eijndhoven, Erik Ganster, Y. Makino, P. Peiffer, Johan Wulff, A. Weindl, Segev BenZvi, Elisa Lohfink, Timothyblake Watson, J. Bourbeau, Nora Valtonen-Mattila, Michael Kovacevich, M. E. Huber, Spencer Klein, Javier Gonzalez, Roxanne Turcotte, Maryon Ahrens, Samvel Ter-Antonyan, Kurt Woschnagg, Marcos Santander, Richard Naab, S. Tilav, Daria Pankova, L. Gerhardt, G. Krückl, Konstancja Satalecka, A. Olivas, Alexander Fritz, D. Z. Besson, Stephanie Bron, E. Friedman, Paul Evenson, Frederik Tenholt, R. Nagai, C. De Clercq, C. Lagunas Gualda, Y. Popovych, C. J. Lozano Mariscal, C. Weaver, Martin Rongen, Theo Glauch, Alejandro Diaz, Michael DuVernois, Seongjin In, Elisa Resconi, Alessio Porcelli, H. Dujmovic, Matthias Vraeghe, Rasha Abbasi, B. J. Whelan, Kara Hoffman, J. Kim, G. W. Sullivan, James E. Braun, T. Kintscher, Simone Garrappa, Xianwu Xu, J. Sandroos, Dmitry Chirkin, Alexander Kappes, K. Rawlins, J. P. Yanez, G. H. Collin, J. Evans, Alan Coleman, David A. Williams, Markus Ackermann, S. W. Barwick, Philipp Furst, Zhedong Zhang, Ava Ghadimi, F. Huang, Emily Dvorak, Hershal Pandya, Frederik Hermann Lauber, R. S. Busse, Surujhdeo Seunarine, R. Snihur, K. Tollefson, E. O'Sullivan, R. Morse, Jakob Bottcher, T. Montaruli, Jan Weldert, Wolfgang Rhode, Robert Stein, Alexander Trettin, N. Kurahashi, Christopher Wiebusch, Kunal Deoskar, Juanan Aguilar, L. Halve, Franziska Tischbein, Justin Lanfranchi, M. Ha Minh, C. Wendt, P. Mallik, M. Stamatikos, K. Meagher, C. Pérez de los Heros, Gerald Przybylski, A. Karle, James Madsen, Chad Finley, Daniel Bindig, R. Halliday, B. J. P. Jones, G. de Wasseige, A. Wallace, Kayla Leonard, Ben Smithers, P. Eller, Simeon Reusch, Lu Lu, T. Anderson, J. C. Gallagher, A. Sharma, Sukeerthi Dharani, Christoph Tönnis, R. Hoffmann, John Hardin, Jean Pierre Twagirayezu, A. Ishihara, Tim Ruhe, A. Haungs, Rui An, Nahee Park, A. Ludwig, Francis Halzen, J. Merz, D. Rysewyk Cantu, C. Walck, Elisa Bernardini, Gerrit Wrede, T. Stanev, K. Hultqvist, Benedikt Riedel, D. Seckel, K. Mase, Andres Medina, Darren Grant, Benjamin Hokanson-Fasig, I. Ansseau, D. Mockler, Thomas Huber, Thomas K. Gaisser, Chiara Bellenghi, Yang Lyu, T. Glüsenkamp, Grant Parker, Jenni Adams, M. Meier, Michael Campana, H. Niederhausen, H. Schieler, Ek Narayan Paudel, Allan Hallgren, Colin Turley, Saskia Philippen, Juliana Stachurska, H. Dembinski, K. Helbing, A. Steuer, Kendall Mahn, A. Goldschmidt, Alexander A. Harnisch, Kirill Filimonov, Kael Hanson, Spencer Axani, Christian Glaser, K. Wiebe, Barbara Skrzypek, S. E. Sanchez Herrera, Stephen L. Hauser, M. J. Weiss, R. G. Stokstad, Lenka Tomankova, Carlos Arguelles, Jessie Micallef, Jannis Necker, Raamis Hussain, D. Kang, M. Silva, I. Taboada, Najia Moureen Binte Amin, Federica Bradascio, Alexander Burgman, J. P. Lazar, Michael O. Wolf, M. Prado Rodriguez, Clara E. Hill, S. Kopper, Paolo Desiati, K. D. de Vries, S. Hickford, I. Safa, Pranav Dave, René Reimann, Merlin Schaufel, Minjin Jeong, Leander Fischer, Qinrui Liu, R. Joppe, Martina Karl, Jochen M. Schneider, Srubabati Goswami, M. A. Unland Elorrieta, Sebastian Baur, Sebastian Fiedlschuster, D. R. Nygren, Marek Kowalski, Olga Botner, V. Baum, T. Stezelberger, S. Yoshida, Won Nam Kang, Sarah Mancina, X. Bai, Tobias Hoinka, Vedant Basu, Steve Sclafani, J. Kiryluk, K. Andeen, A.A. Alves, Alexander Sandrock, Pablo Correa, B. A. Clark, P. Schlunder, Sebastian Böser, Benjamin Bastian, Anastasia Maria Barbano, Gisela Anton, Max Renschler, Chunfai Tung, D. J. Koskinen, S. Robertson, E. Bourbeau, Joshua Hignight, Spencer Griswold, Maria Tselengidou, D. Soldin, Ramesh Koirala, E. Blaufuss, L. Classen, K. Hoshina, Glenn Spiczak, G. Momenté, M. Rameez, D. F. Cowen, U. Naumann, David Vannerom, Le Viet Nguyen, K. Krings, J. Stettner, M. Plum, Gerrit Roellinghoff, Mirco Hunnefeld, Marie Oehler, Z. Griffith, Xinyue Kang, Claudio Kopper, Subir Sarkar, Felix Henningsen, A. R. Fazely, Simona Toscano, C. Alispach, Physics, Faculty of Sciences and Bioengineering Sciences, Elementary Particle Physics, and Vriendenkring VUB
Subjects: Particle physics, Physics::Instrumentation and Detectors, Computer science, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, General Physics and Astronomy, CHERENKOV LIGHT YIELD, Weighting, 01 natural sciences, High Energy Physics - Experiment, 010305 fluids & plasmas, Standard Model, High Energy Physics - Experiment (hep-ex), Neutrino interaction, High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, 010306 general physics, Cherenkov radiation, Event generator, Neutrino generator, Neutrino simulation, Generator (computer programming), hep-ex, Event (computing), ICE, High Energy Physics::Phenomenology, Detector, hep-ph, Computational Physics (physics.comp-ph), Quantitative Biology::Genomics, High Energy Physics - Phenomenology, physics.comp-ph, Hardware and Architecture, High Energy Physics::Experiment, Neutrino, Physics - Computational Physics, Lepton
Abstract: We present a high-energy neutrino event generator, called LeptonInjector, alongside an event weighter, called LeptonWeighter. Both are designed for large-volume Cherenkov neutrino telescopes such as IceCube. The neutrino event generator allows for quick and flexible simulation of neutrino events within and around the detector volume, and implements the leading Standard Model neutrino interaction processes relevant for neutrino observatories: neutrino-nucleon deep-inelastic scattering and neutrino-electron annihilation. In this paper, we discuss the event generation algorithm, the weighting algorithm, and the main functions of the publicly available code, with examples., Comment: 28 pages, 10 figures, 3 tables
Published: 2021
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38. The IceCube realtime alert system

Author: B. J. P. Jones, Chris Wendt, S. Hickford, D. Tosi, M. Day, R. Konietz, M. Vehring, S. Coenders, Joshua Hignight, Francis Halzen, Karim Ghorbani, S. Seunarine, G. Merino, Spencer Axani, I. Ansseau, N. Wandkowsky, S. Schoenen, J. Kiryluk, M. Wolf, F. Bos, A. Terliuk, Sally Robertson, G. Krückl, Carlos Arguelles, M. Song, T. L. Carver, Mike Richman, H. Dembinski, Sebastian Böser, D. Heereman, P. Schlunder, R. Nahnhauer, M. Lesiak-Bzdak, Gisela Anton, V. di Lorenzo, Allan Hallgren, J. Tatar, M. J. Larson, Jae Yool Kim, M. Kauer, L. Classen, Kurt Woschnagg, T. Menne, Paul Evenson, L. Brayeur, C. Finley, Juanan Aguilar, Jenni Adams, Hrvoje Dujmovic, Janet Conrad, B. Relethford, Ignacio Taboada, A. Obertacke Pollmann, K. Rawlins, M. G. Aartsen, Michael Sutherland, K. Mase, T. Kittler, S. Flis, P. Peiffer, R. Cross, K. D. de Vries, George Japaridze, S. De Ridder, Dirk Lennarz, Konstancja Satalecka, Theo Glauch, M. Rongen, Gabriel Collin, Dmitry Chirkin, A. Franckowiak, D. Z. Besson, Marjon Moulai, James Madsen, Lu Lu, R. Maunu, E. Friedman, Alexander Kappes, R. G. Stokstad, Markus Ahlers, J. Kunnen, Jay Gallagher, T. Ehrhardt, N. van Eijndhoven, M. N. Tobin, A. Meli, C.-C. Fösig, M. van Rossem, M. Vraeghe, C. Haack, K. Meagher, Elisa Resconi, A. Steuer, Teresa Montaruli, M. J. Weiss, N. Kurahashi, B. J. Whelan, Todor Stanev, R. Hellauer, D. Bose, Kendall Mahn, N. L. Strotjohann, J. P. Dumm, M. Relich, A. Olivas, K. Helbing, T. Palczewski, H. Pandya, M. Bissok, K. Jero, A. Wallace, R. Reimann, E. Vogel, Maryon Ahrens, U. Katz, J. C. Díaz-Vélez, S. Kopper, E. Woolsey, G. Binder, Joshua Pepper, H. Niederhausen, Dawn Williams, F. Huang, M. Leuermann, G. de Wasseige, A. Turcati, U. Naumann, E. Hansen, M. E. Huber, B. Eberhardt, M. S. Kim, Samvel Ter-Antonyan, Aya Ishihara, D. Bindig, E. Jacobi, Elisa Bernardini, Segev BenZvi, G. Maggi, T. Schmidt, L. Wille, Y. Xu, J. Lünemann, M. Kowalski, S. E. Sanchez Herrera, Azadeh Keivani, Frederik Tenholt, M. Rameez, M. Medici, L. Gerhardt, D. F. Cowen, Albrecht Karle, S. Euler, T. Fuchs, T. Karg, Ch. Weaver, Alexander Burgman, W. Kang, Z. Griffith, S. Miarecki, J. van Santen, Kael Hanson, Thomas Meures, K. Krings, K. Clark, D. V. Pankova, F. McNally, G. W. Sullivan, M. Casier, B. Riedel, D. R. Nygren, S. Bron, Steven W. Barwick, M. Tselengidou, Thomas K. Gaisser, G. B. Yodh, Spencer Klein, A. Stasik, Stijn Vanheule, Philipp Eller, Maximilian Meier, T. Ruhe, S. Wickmann, J. Auffenberg, D. Hebecker, Paolo Desiati, A. Sandrock, T. Glüsenkamp, Gerald Przybylski, Minjin Jeong, G. Neer, T. Kintscher, Hermann Kolanoski, M. Labare, M. Quinnan, M. Dunkman, J. Felde, H. Taavola, Stijn Blot, Christian Spiering, S. Yoshida, Xinhua Bai, T. Hansmann, R. Hoffmann, Javier Gonzalez, M. Mandelartz, E. Blaufuss, Kara Hoffman, E. Pinat, Olga Botner, K. Wiebe, P. B. Price, V. Baum, D. J. Koskinen, D. Ryckbosch, Simona Toscano, M. Voge, Markus Ackermann, Donglian Xu, J. Becker Tjus, Ö. Penek, D. Soldin, L. Rädel, J. Stettner, Justin Vandenbroucke, K. Hoshina, E. del Pino Rosendo, Subir Sarkar, Glenn Spiczak, S. Schöneberg, K. H. Becker, E. Unger, D. Berley, W. Giang, J. L. Lanfranchi, Wolfgang Rhode, J. L. Kelley, S. In, S. C. Nowicki, L. Gladstone, R. Koirala, Darren Grant, J. P. A. M. de André, C. Walck, Sarah Mancina, Frederik Hermann Lauber, M. Börner, Klas Hultqvist, M. Zoll, K. Andeen, S. Westerhoff, A. Christov, M. Wallraff, T. Stezelberger, E. Cheung, M. Usner, L. Sabbatini, B. Eichmann, H.-P. Bretz, S. Tilav, Christian Bohm, Aongus O'Murchadha, J. P. Yanez, Christoph Raab, G. C. Hill, L. Schumacher, C. Krüger, A. Goldschmidt, R. C. Bay, D. Seckel, S. Fahey, S. Kunwar, M. Archinger, A. R. Fazely, Tyce DeYoung, P. A. Toale, M. Kroll, C. Kopper, J. Braun, T. R. Wood, J. J. Beatty, A. Bernhard, D. Rysewyk, A. Stößl, Reina H. Maruyama, Christopher Wiebusch, J. Feintzeig, Carsten Rott, Xianwu Xu, J. Sandroos, D. Altmann, C. Pérez de los Heros, R. Ström, T. Kuwabara, L. Wills, Damian Pieloth, Ali Kheirandish, L. Köpke, G. Kohnen, T. Anderson, C. De Clercq, G. Tešić, Kirill Filimonov, Physics, Elementary Particle Physics, Faculty of Sciences and Bioengineering Sciences, and Vriendenkring VUB
Subjects: HIGH-ENERGY NEUTRINOS, TELESCOPE, Astrophysics::High Energy Astrophysical Phenomena, Multi-messenger astronomy, Neutrino astronomy, Neutrino detectors, Transient sources, Astronomy and Astrophysics, pole, FOS: Physical sciences, 01 natural sciences, IceCube, law.invention, IceCube Neutrino Observatory, Telescope, SEARCHES, CORE-COLLAPSE SUPERNOVAE, law, Observatory, 0103 physical sciences, site, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, background, Event (computing), Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, PERFORMANCE, sensitivity, observatory, Identification (information), electromagnetic, Physics and Astronomy, Neutrino detector, ddc:540, High Energy Physics::Experiment, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, FOLLOW-UP
Abstract: Following the detection of high-energy astrophysical neutrinos in 2013, their origin is still unknown. Aiming for the identification of an electromagnetic counterpart of a rapidly fading source, we have implemented a realtime analysis framework for the IceCube neutrino observatory. Several analyses selecting neutrinos of astrophysical origin are now operating in realtime at the detector site in Antarctica and are producing alerts to the community to enable rapid follow-up observations. The goal of these observations is to locate the astrophysical objects responsible for these neutrino signals. This paper highlights the infrastructure in place both at the South Pole detector site and at IceCube facilities in the north that have enabled this fast follow-up program to be developed. Additionally, this paper presents the first realtime analyses to be activated within this framework, highlights their sensitivities to astrophysical neutrinos and background event rates, and presents an outlook for future discoveries., Comment: 33 pages, 9 figures, Published in Astroparticle Physics
Published: 2017
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39. A search for time-dependent astrophysical neutrino emission with IceCube data from 2012 to 2017

Author: Alexander Trettin, J. C. Gallagher, Gerrit Wrede, Federica Bradascio, S. Tilav, K. Rawlins, Alexander Burgman, C. J. Lozano Mariscal, K. Helbing, Thomas Huber, Ek Narayan Paudel, Allan Hallgren, J. P. Yanez, H. Dujmovic, D. Tosi, James Madsen, Lu Lu, P. Schlunder, Rasha Abbasi, B. J. Whelan, Won Nam Kang, D. Kang, Elisa Lohfink, X. Bai, I. Safa, A. Wallace, Surujhdeo Seunarine, R. Snihur, Juanan Aguilar, I. Taboada, Michael DuVernois, P. B. Price, Francesco Lucarelli, Merlin Schaufel, Michael O. Wolf, T. O. B. Schmidt, Sarah Mancina, Minjin Jeong, T. Glüsenkamp, Kurt Woschnagg, Simon Hauser, Paul Evenson, K. D. de Vries, Simone Garrappa, M. Meier, David Vannerom, Michael Campana, Dmitry Chirkin, Gerald Przybylski, Alexander Kappes, Jan Weldert, L. Halve, M. Ha Minh, Tobias Hoinka, R. Halliday, Antonio Augusto Alves Jr., A. Ishihara, K. Tollefson, A. Desai, Vedant Basu, Steve Sclafani, M. Stamatikos, B. J. P. Jones, Thomas Ehrhardt, J. Kiryluk, Alexander Sandrock, Kendall Mahn, Gisela Anton, Karl J. Clark, K. Andeen, Christian Haack, C. Pérez de los Heros, Jan Soedingrekso, Frank G. Schröder, Paras Koundal, Mike Richman, Andres Medina, Z. Griffith, A. Goldschmidt, George Japaridze, Saskia Philippen, Pablo Correa, D. Mockler, Simeon Reusch, Michael Kovacevich, Roger Moore, S. Yoshida, B. A. Clark, G. Krückl, Benjamin Hokanson-Fasig, D. Rysewyk Cantu, A. Obertacke Pollmann, U. Katz, K. Hoshina, D. Hebecker, J. Bourbeau, D. R. Nygren, Yang Lyu, Richard Naab, Grant Parker, Lenka Tomankova, Alejandro Diaz, N. van Eijndhoven, D. F. Cowen, Glenn Spiczak, Marek Kowalski, J. L. Kelley, Markus Ahlers, Spencer Axani, Aaron Fienberg, Daria Pankova, E. Friedman, M. Silva, Seongjin In, Elisa Resconi, Alessio Porcelli, E. O'Sullivan, Lisa Johanna Schumacher, Najia Moureen Binte Amin, C. Alispach, Amirreza Raissi, Janet Conrad, Stephanie Bron, Felix Henningsen, M. J. Larson, Le Viet Nguyen, Emily Dvorak, G. Momenté, M. Rameez, M. Prado Rodriguez, Pranav Dave, Carlos Arguelles, K. Wiebe, J. P. Lazar, Clara E. Hill, Erik Ganster, Shefali Shefali, Samvel Ter-Antonyan, A. Steuer, Chunfai Tung, D. B. Fox, Jessie Micallef, Chad Finley, Christoph Tönnis, Raamis Hussain, Abdul Rehman, Carsten Rott, Y. Popovych, K. Krings, Jenni Adams, K. Mase, Alexander A. Harnisch, S. Robertson, Joshua Hignight, R. Cross, Johannes Werthebach, Wing Yan Ma, James DeLaunay, Marjon Moulai, Simona Toscano, Benedikt Riedel, D. Seckel, M. Plum, Y. Makino, Alexander Fritz, D. Z. Besson, Javier Gonzalez, Roxanne Turcotte, M. J. Weiss, R. Morse, Jakob Bottcher, T. Montaruli, S. De Ridder, Xianwu Xu, J. Sandroos, Matthias Vraeghe, Christian Glaser, Brandom Pries, S. Hickford, Paul Coppin, Maximilian Karl Scharf, Xinyue Kang, Olga Botner, S. Kopper, J. Kim, René Reimann, Hermann Kolanoski, R. G. Stokstad, A. V. Balagopal, Andrea Turcati, J. Evans, C. De Clercq, Kael Hanson, U. Naumann, Claudio Kopper, A. Franckowiak, T. Stezelberger, Timo Karg, V. Baum, Leander Fischer, R. Joppe, Stef Verpoest, Jannis Necker, C. Lagunas Gualda, Chujie Chen, T. Gregoire, A. Weindl, Maryon Ahrens, Subir Sarkar, K. Meagher, William Luszczak, P. Peiffer, Daniel Bindig, G. H. Collin, Frederik Tenholt, R. Nagai, Johan Wulff, Timothyblake Watson, Paolo Desiati, C. Weaver, M. E. Huber, Sebastian Baur, Marcos Santander, Ramesh Koirala, Sebastian Fiedlschuster, Alan Coleman, David A. Williams, J. van Santen, J. Stettner, L. Gerhardt, A. Olivas, Konstancja Satalecka, E. Blaufuss, Alex Pizzuto, Markus Ackermann, Theo Glauch, S. W. Barwick, Elisa Bernardini, A. Kyriacou, L. Classen, Gary Binder, D. van Eijk, Sebastian Böser, F. Huang, Gerrit Roellinghoff, J. Becker Tjus, Mark Weyrauch, Kayla Leonard, Y. L. Li, Sukeerthi Dharani, Francis Halzen, J. Merz, Mirco Hunnefeld, Marie Oehler, I. Ansseau, Benjamin Bastian, Anastasia Maria Barbano, Juliana Stachurska, H. Dembinski, G. W. Sullivan, Max Renschler, James E. Braun, D. J. Koskinen, M. Kauer, Suyong Choi, E. Bourbeau, David Kappesser, Matti Jansson, N. Kurahashi, Spencer Griswold, Todor Stanev, C. Wendt, Maria Tselengidou, D. Soldin, Philipp Furst, Mehmet Gunduz, G. de Wasseige, R. Hoffmann, C. Walck, Thomas K. Gaisser, Agnieszka Leszczyńska, R. C. Bay, Tim Ruhe, Austin Schneider, A. Ludwig, H. Niederhausen, Juan Carlos Diaz-Velez, Ken'ichi Kin, J. J. Beatty, Tianlu Yuan, F. McNally, Emma C. Hettinger, Reina H. Maruyama, Summer Blot, Segev BenZvi, Spencer Klein, Kara Hoffman, Hershal Pandya, Wolfgang Rhode, Robert Stein, T. Anderson, John Hardin, Chiara Bellenghi, H. Schieler, Kirill Filimonov, Damian Pieloth, Ali Kheirandish, Jannes Brostean-Kaiser, Ben Smithers, M. U. Nisa, L. Köpke, Jean Pierre Twagirayezu, A. Haungs, Nahee Park, K. Hultqvist, Darren Grant, T. Kintscher, Frederik Hermann Lauber, Justin Lanfranchi, Christian Spiering, Justin Vandenbroucke, S. C. Nowicki, S. E. Sanchez Herrera, K.-H. Becker, Yiqian Xu, Matt Dunkman, Thomas Stuttard, Sarah Pieper, Dirk Ryckbosch, Stephan Meighen-Berger, Qinrui Liu, Martina Karl, Jochen M. Schneider, Srubabati Goswami, M. A. Unland Elorrieta, Martin Rongen, Zhedong Zhang, Ava Ghadimi, Franziska Tischbein, P. Mallik, P. Eller, Colin Turley, R. S. Busse, Christopher Wiebusch, Kunal Deoskar, A. Karle, Ioana Codrina Maris, Christoph Raab, Nadège Iovine, D. Berley, G. C. Hill, Bunheng Ty, Ralph Engel, Moritz Kellermann, Giovanni Renzi, S. Fahey, A. R. Fazely, Tyce DeYoung, Nathan Whitehorn, Immacolata Carmen Rea, Physics, Faculty of Sciences and Bioengineering Sciences, Elementary Particle Physics, and Vriendenkring VUB
Subjects: 010504 meteorology & atmospheric sciences, High-energy astronomy, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, model [emission], FOS: Physical sciences, Cosmic ray, Astrophysics, 01 natural sciences, law.invention, IceCube Neutrino Observatory, IceCube, blazar, law, emission [gamma ray], 0103 physical sciences, Cosmic ray sources, High-energy astrophysics, Particle astrophysics, energy: high [neutrino], Blazar, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, media_common, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Astroparticle physics, Physics, background, Astronomy and Astrophysics, Universe, messenger, observatory, Space and Planetary Science, ddc:520, time dependence, acceleration [cosmic radiation], Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Flare
Abstract: High-energy neutrinos are unique messengers of the high-energy universe, tracing the processes of cosmic ray acceleration. This paper presents analyses focusing on time-dependent neutrino point-source searches. A scan of the whole sky, making no prior assumption about source candidates, is performed, looking for a space and time clustering of high-energy neutrinos in data collected by the IceCube Neutrino Observatory between 2012 and 2017. No statistically significant evidence for a time-dependent neutrino signal is found with this search during this period, as all results are consistent with the background expectation. Within this study period, the blazar 3C 279, showed strong variability, inducing a very prominent gamma-ray flare observed in 2015 June. This event motivated a dedicated study of the blazar, which consists of searching for a time-dependent neutrino signal correlated with the gamma-ray emission. No evidence for a time-dependent signal is found. Hence, an upper limit on the neutrino fluence is derived, allowing us to constrain a hadronic emission model.
Published: 2020
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40. Identifying Galactic Sources of High-Energy Neutrinos

Author: Ali Kheirandish
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), COSMIC cancer database, High-energy astronomy, Milky Way, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, Flux, FOS: Physical sciences, Astronomy and Astrophysics, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Cosmology, Space and Planetary Science, 0103 physical sciences, High Energy Physics::Experiment, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics
Abstract: High-energy neutrinos present the ultimate signature for a cosmic ray accelerator. Galactic sources responsible for acceleration of cosmic ray up to the knee in cosmic ray spectrum will provide a guaranteed, albeit subdominant, contribution to the high-energy cosmic neutrino flux. In this review, we discuss the the prospects for identification of high-energy neutrinos from sources of the very high energy gamma ray emission in the Milky Way. We present the status of the search for point-like and extended emission from these sources, and describe how the results of these studies indicate that neutrino telescopes are closing in on identifying Galactic sources of high-energy neutrinos., Comment: Review article for Topical Collection: Plasma, Particles, and Photons: ISM Physics Revisited
Published: 2020
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41. Neutrinos below 100 TeV from the southern sky employing refined veto techniques to IceCube data

Author: A. O'Murchadha, D. J. Koskinen, Timothyblake Watson, Timo Karg, A. Kyriacou, E. Bourbeau, R. Maunu, C. Pérez de los Heros, T. Menne, Matthias Vraeghe, Maria Tselengidou, E. O’Sullivan, B. Relethford, J. Auffenberg, Raffaela Busse, D. Soldin, K. Rawlins, Claudio Kopper, J. Becker Tjus, Konstancja Satalecka, Subir Sarkar, Z. Griffith, Theo Glauch, R. Hellauer, K. Mallot, B. J. P. Jones, U. Katz, Minjin Jeong, James W. Wood, James Madsen, Thomas Meures, K. Hoshina, M. E. Huber, P. B. Price, Benjamin Hokanson-Fasig, N. L. Strotjohann, Segev BenZvi, Felix Henningsen, Glenn Spiczak, G. Momenté, M. Rameez, Lu Lu, Marcos Santander, R. Ström, Won Nam Kang, A. R. Fazely, H. Bagherpour, E. Pinat, P. Backes, X. Bai, D. van Eijk, Simona Toscano, D. F. Cowen, U. Naumann, K. D. de Vries, Spencer Klein, Andres Medina, Olga Botner, S. Tilav, E. Unger, L. Gerhardt, G. Neer, T. Kintscher, Francesco Lucarelli, Frederik Hermann Lauber, S. Hickford, A. Olivas, J. J. Beatty, Daniel Bindig, J. P. Yanez, N. Kulacz, G. H. Collin, Azadeh Keivani, T. Glüsenkamp, T. O. B. Schmidt, V. Baum, Teresa Montaruli, K. Jero, Tianlu Yuan, Sebastian Böser, C. Chen, Kara Hoffman, Kendall Mahn, K. Wiebe, J. Stettner, Hermann Kolanoski, A. Terliuk, S. Westerhoff, T. R. Wood, Justin Lanfranchi, R. Turcotte, K. Helbing, Yiqian Xu, Karl J. Clark, Matt Dunkman, Hrvoje Dujmovic, Sander Vanheule, Javier Gonzalez, L. Rauch, Anastasia Maria Barbano, Kurt Woschnagg, T. Kittler, G. W. Sullivan, Giorgio Maggi, James E. Braun, Alexander Sandrock, Thomas Ehrhardt, E. Cheung, Thomas Stuttard, H.-P. Bretz, Qinrui Liu, Martina Karl, M. Song, T. L. Carver, Mike Richman, Jochen M. Schneider, Paul Evenson, Hershal Pandya, C. De Clercq, Mirco Hunnefeld, Wolfgang Rhode, Dirk Ryckbosch, Nahee Park, K. Hultqvist, Stephan Meighen-Berger, Chunfai Tung, S. Yoshida, Elisa Bernardini, David A. Williams, Robert Stein, Lenka Tomankova, D. Hebecker, Karim Ghorbani, Spencer Axani, Simone Garrappa, Darren Grant, L. Wills, Markus Ackermann, S. W. Barwick, M. Stamatikos, D. Rysewyk, M. Silva, Kayla Leonard, M. J. Larson, M. A. Unland Elorrieta, Dmitry Chirkin, Sarah Mancina, Sarah Nowicki, Alexander Kappes, N. Kurahashi, Jenni Adams, I. Taboada, P. Peiffer, Joshua Hignight, Todor Stanev, C. Wendt, Paul Coppin, Michael O. Wolf, P. Nakarmi, Carlos Arguelles, J. P. A. M. de André, N. van Eijndhoven, C. Haack, Delia Tosi, Anna Franckowiak, Tobias Hoinka, Andrea Turcati, Jessie Micallef, A. Goldschmidt, Jung-Hyun Kim, Ibrahim Safa, Francis Halzen, P. Schlunder, G. de Wasseige, M. Wallraff, F. Huang, J. van Santen, A. Stößl, M. Börner, Steve Sclafani, Damian Pieloth, Ali Kheirandish, W. Van Driessche, J. Kiryluk, Alex Pizzuto, Daria Pankova, R. Hoffmann, E. Friedman, George Japaridze, Roger Moore, Gary Binder, Christian Spiering, D. R. Nygren, Reina H. Maruyama, I. Ansseau, K. Becker, Jan Soedingrekso, C. Walck, Marek Kowalski, Steven Robertson, Elisa Lohfink, K. Andeen, Jannes Brostean-Kaiser, Summer Blot, Thomas K. Gaisser, G. B. Yodh, J. Bourbeau, E. Jacobi, R. G. Stokstad, R. Nahnhauer, Gisela Anton, A. Stasik, Justin Vandenbroucke, Juliana Stachurska, H. Dembinski, Emily Dvorak, L. Köpke, Alexander Fritz, D. Z. Besson, Chad Finley, G. Krückl, L. Schumacher, Carsten Rott, Tim Ruhe, Colin Turley, C. Alispach, Seongjin In, Gerald Przybylski, Elisa Resconi, T. Anderson, M. G. Aartsen, Janet Conrad, Federica Bradascio, Alexander Burgman, Pablo Correa, H. Niederhausen, K. Mase, Yuya Makino, R. Cross, Xianwu Xu, Christoph Tönnis, J. Sandroos, Mehmet Gunduz, Johannes Werthebach, M. S. Sutherland, A. Ishihara, R. C. Bay, M. J. Weiss, Kirill Filimonov, Austin Schneider, J. C. Gallagher, Juan Carlos Diaz-Velez, M. Usner, S. Kopper, M. Leuermann, Gerrit Wrede, Kael Hanson, René Reimann, William Luszczak, Allan Hallgren, M. Kauer, Martin Rongen, Pranav Dave, Samridha Kunwar, D. Altmann, K. Meagher, David Kappesser, L. Wille, S. E. Sanchez Herrera, Maximilian Meier, T. Palczewski, Paolo Desiati, M. Günder, D. Heereman, T. Stezelberger, A. Steuer, B. Eberhardt, Raamis Hussain, J. Lünemann, Amirreza Raissi, Chris Weaver, Stephanie Bron, C. J. Lozano Mariscal, G. Merino, N. Wandkowsky, Surujhdeo Seunarine, R. Snihur, Juanan Aguilar, B. J. Whelan, Immacolata Carmen Rea, K. Krings, Jan Weldert, L. Halve, Philipp Eller, M. Plum, Ramesh Koirala, E. Blaufuss, J. Felde, Merlin Schaufel, L. Classen, A. Obertacke Pollmann, A. Wallace, J. L. Kelley, Da Xu, Markus Ahlers, James DeLaunay, Marjon Moulai, S. De Ridder, Christopher Wiebusch, Kunal Deoskar, M. Labare, A. Karle, Erik Ganster, Ioana Codrina Maris, Christian Bohm, Samvel Ter-Antonyan, Christoph Raab, Nadège Iovine, D. Berley, G. C. Hill, Bunheng Ty, Maryon Ahrens, Giovanni Renzi, D. Seckel, Frederik Tenholt, S. Fahey, R. Nagai, M. Medici, S. Miarecki, Tyce DeYoung, Nathan Whitehorn, Jeffrey Lazar, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Elementary Particle Physics
Subjects: background [atmosphere], Physics::Instrumentation and Detectors, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, pole, FOS: Physical sciences, 01 natural sciences, High Energy Physics - Experiment, IceCube Neutrino Observatory, IceCube, charged current, High Energy Physics - Experiment (hep-ex), Neutrinos, Point sources, Veto techniques, SEARCH, TRACK RECONSTRUCTION, 0103 physical sciences, supernova, Muon neutrino, atmosphere [muon], 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, media_common, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, neutrino muon, Muon, 010308 nuclear & particles physics, ICE, Galactic Center, High Energy Physics::Phenomenology, Astronomy, Astronomy and Astrophysics, flux [neutrino], Galactic plane, observatory, Supernova, Physics and Astronomy, Sky, energy [neutrino], gamma ray, ddc:540, spectral, High Energy Physics::Experiment, galaxy, Neutrino, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Many Galactic sources of gamma rays, such as supernova remnants, are expected to produce neutrinos with a typical energy cutoff well below 100 TeV. For the IceCube Neutrino Observatory located at the South Pole, the southern sky, containing the inner part of the Galactic plane and the Galactic Center, is a particularly challenging region at these energies, because of the large background of atmospheric muons. In this paper, we present recent advancements in data selection strategies for track-like muon neutrino events with energies below 100 TeV from the southern sky. The strategies utilize the outer detector regions as veto and features of the signal pattern to reduce the background of atmospheric muons to a level which, for the first time, allows IceCube searching for point-like sources of neutrinos in the southern sky at energies between 100 GeV and several TeV in the muon neutrino charged current channel. No significant clustering of neutrinos above background expectation was observed in four years of data recorded with the completed IceCube detector. Upper limits on the neutrino flux for a number of spectral hypotheses are reported for a list of astrophysical objects in the southern hemisphere., 19 pages, 17 figures, 2 tables
Published: 2020
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42. Dark Matter Annihilation to Neutrinos

Author: Andrés Olivares-Del-Campo, Aaron C. Vincent, Alejandro Diaz, Carlos Arguelles, Ibrahim Safa, and Ali Kheirandish
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Annihilation, 010308 nuclear & particles physics, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, High Energy Physics::Phenomenology, Massive particle, General Physics and Astronomy, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 7. Clean energy, 01 natural sciences, Universe, Standard Model, High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), Orders of magnitude (time), 0103 physical sciences, Neutrino, 010306 general physics, Astrophysics - High Energy Astrophysical Phenomena, media_common
Abstract: We review the annihilation of dark matter into neutrinos over a range of dark matter masses from MeV$/c^2$ to ZeV$/c^2$. Thermally-produced models of dark matter are expected to self-annihilate to standard model products. As no such signal has yet been detected, we turn to neutrino detectors to constrain the ``most invisible channel.'' We review the experimental techniques that are used to detect neutrinos, and revisit the expected contributions to the neutrino flux at current and upcoming neutrino experiments. We place updated constraints on the dark matter self-annhilation cross section to neutrinos $\langle \sigma v \rangle$ using the most recently available data, and forecast the sensitivity of upcoming experiments such as Hyper-Kamiokande, DUNE, and IceCube Gen-2. Where possible, limits and projections are scaled to a single set of dark matter halo parameters for consistent comparison. We consider Galactic and extragalactic signals of $s$, $p$, and $d$-wave annihilation processes directly into neutrino pairs, yielding constraints that range from $\langle \sigma v \rangle \sim 2.5\times10^{-26}~{\rm cm}^3 {\rm s}^{-1}$ at 30 MeV$/c^2$ to $10^{-17}~{\rm cm}^3{\rm s}^{-1}$ at 10$^{11}$ GeV$/c^2$. Experiments that report directional and energy information of their events provide much stronger constraints, outlining the importance of making such data public., Comment: 30 pages, 8 figures. Accepted for publication in Reviews of Modern Physics
Published: 2019

43. IceCube Search for Galactic Neutrino Sources based on HAWC Observations of the Galactic Plane

Author: Joshua A. Wood, IceCube, Ali Kheirandish, and Hawc Collaborations
Subjects: Physics, High energy, Pion, Photon, Observatory, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment, Astrophysics, Galactic plane, Neutrino, Lepton
Abstract: We present a search in IceCube data for neutrino emission from Galactic TeV gamma-ray sources detected by the HAWC gamma-ray observatory. HAWC serves as the excellent instrument to complement IceCube with its energy range extending to very high energies. Assuming that the highest energy photons originate from the decay of pions, rather than from accelerated leptons, the very high energy gamma-rays observed by HAWC are expected to be correlated with neutrinos. Using eight years of IceCube data, we report on two analyses that investigate a possible neutrino--gamma ray correlation. The first is a stacked analysis of identified HAWC point sources and the second is a template method which accounts for the full morphology of HAWC sources, including their measured extension.
Published: 2019
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44. Searches for neutrinos from fast radio bursts with IceCube

Author: Justin Vandenbroucke, Ali Kheirandish, S. Fahey, and Donglian Xu
Subjects: Physics, Muon, Physics::Instrumentation and Detectors, Observatory, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Flux, High Energy Physics::Experiment, Astrophysics, Neutrino, Radio wave
Abstract: Although IceCube has discovered a diffuse astrophysical neutrino flux, the underlying sources of these neutrinos remain unknown. Transient astrophysical objects, such as fast radio bursts (FRBs), could explain a large percentage of the measured flux. We present the analysis techniques of IceCube searches for MeV to TeV neutrinos from FRBs. As no significant correlation between IceCube neutrinos and FRBs has been found, we present the first limit on MeV neutrino emission from FRBs and the most constraining limits for neutrinos with GeV to TeV energies. We also describe the prospects for future IceCube neutrino searches coinciding with FRB detections from next generation radio interferometers.
Published: 2019
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45. Fundamental Physics with High-Energy Astrophysical Neutrinos Today and in the Future

Author: Sergio Palomares-Ruiz, Aaron C. Vincent, Carlos Arguelles, Ali Kheirandish, Jordi Salvado, and Mauricio Bustamante
Subjects: Physics, High energy, Particle physics, Astrophysics::High Energy Astrophysical Phenomena, Physics beyond the Standard Model, Fundamental physics, Astrophysics::Instrumentation and Methods for Astrophysics, High Energy Physics::Experiment, Observable universe, Neutrino
Abstract: The astrophysical neutrinos discovered by IceCube have the highest detected neutrino energies --- from TeV to PeV --- and likely travel the longest distances --- up to a few Gpc, the size of the observable Universe. These features make them naturally attractive probes of fundamental particle-physics properties, possibly tiny in size, at energy scales unreachable by any other means. The decades before the IceCube discovery saw many proposals of particle-physics studies in this direction. Today, those proposals have become a reality, in spite of astrophysical unknowns. We will showcase examples of doing fundamental neutrino physics at these scales, including some of the most stringent tests of physics beyond the Standard Model. In the future, larger neutrino energies --- up to tens of EeV --- could be observed with larger detectors and further our reach.
Published: 2019
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46. Multimessenger Search for the Sources of Cosmic Rays Using Cosmic Neutrinos

Author: Ali Kheirandish and Francis Halzen
Subjects: Physics, COSMIC cancer database, 010308 nuclear & particles physics, lcsh:Astronomy, Astrophysics::High Energy Astrophysical Phenomena, blazars, lcsh:QC801-809, Astrophysics::Instrumentation and Methods for Astrophysics, Flux, neutrinos, Astronomy and Astrophysics, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Connection (mathematics), lcsh:QB1-991, lcsh:Geophysics. Cosmic physics, cosmic rays, 0103 physical sciences, multimessenger, Neutrino, cosmic accelerators, Blazar, 010303 astronomy & astrophysics
Abstract: After updating the status of the measurements of the cosmic neutrino flux by the IceCube experiment, we summarize the evidence for the first identified source of cosmic rays and speculate on the connection between the two observations.
Published: 2019
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47. χaroν: a tool for neutrino flux generation from WIMPs

Author: Jeffrey Lazar, Carlos Arguelles, Ali Kheirandish, and Qinrui Liu
Subjects: Physics, Annihilation, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Electroweak interaction, Dark matter, Astronomy and Astrophysics, Observable universe, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, Standard Model, Galactic halo, High Energy Physics - Phenomenology, 0103 physical sciences, High Energy Physics::Experiment, Neutrino, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Indirect searches for signatures of corpuscular dark matter have been performed using all cosmic messengers: gamma rays, cosmic rays, and neutrinos. The search for dark matter from neutrinos is of particular importance since they are the only courier that can reach detectors from dark matter processes in dense environments, such as the core of the Sun or Earth, or from the edge of the observable Universe. In this work, we introduce $\chi$aro$\nu$, a software package that, in the spirit of its mythological Greek namesake $\chi \acute\alpha \rho \omega \nu $, bridges the dark sector and Standard Model by predicting neutrino fluxes from different celestial dark matter agglomerations. The flux at the point of production is either computed internally by $\chi$aro$\nu$ or is taken from user supplied tables. $\chi$aro$\nu$ then propagates this flux through vacuum or dense media and returns the expected neutrino yield at an observer's location. In developing $\chi$aro$\nu$, we have revisited and updated the production of neutrinos in dense media, updated the propagation of high-energy neutrinos, and studied the sources of uncertainty in neutrino transport. This package is coupled to a new calculation that includes electroweak corrections resulting in the most up-to-date and complete repository of neutrino fluxes from dark matter decay and annihilation over the energy range of 1 GeV to 10 PeV coming from the Earth, the Sun, and the Galactic halo., Comment: 29 pages, 12 figures, code available at: https://github.com/IceCubeOpenSource/charon - comments received are addressed
Published: 2020
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48. Erratum to: Search for annihilating dark matter in the Sun with 3 years of IceCube data

Author: B. Eichmann, H.-P. Bretz, L. Köpke, Christian Bohm, B. Relethford, Aongus O'Murchadha, Christoph Raab, Athina Meli, G. C. Hill, C. Krüger, T. R. Wood, Christopher Wiebusch, S. Fahey, M. Voge, A. R. Fazely, Aya Ishihara, Dennis Soldin, H. Taavola, E. Jacobi, G. Kohnen, L. Gladstone, P. A. Evenson, B. J. P. Jones, S. Euler, C. Pérez de los Heros, Logan Wille, P. Peiffer, M. Day, Matthew Relich, Sally Robertson, G. W. Sullivan, D. J. Koskinen, R. Koirala, J. Braun, D. Seckel, Albrecht Karle, B. Eberhardt, D. Bose, J. P. Dumm, S. Flis, Sebastian Böser, S. Miarecki, D. Z. Besson, P. Schlunder, D. Chirkin, Azadeh Keivani, T. Palczewski, D. V. Pankova, T. Stezelberger, B. Riedel, Matthias Wolf, A. Stasik, Matthew Weiss, Chad Finley, G. Krückl, Hermann Kolanoski, D. R. Nygren, Ö. Penek, S. Schöneberg, E. Vogel, K. Meagher, A. Turcati, T. Kittler, G. H. Collin, Marek Kowalski, J. Kim, E. Hansen, Matthias Huber, V. Baum, Gisela Anton, J. van Santen, C. Kopper, F. Tenholt, A. Stößl, J. A. Pepper, Kurt Becker, Kael Hanson, J. Feintzeig, N. van Eijndhoven, Dirk Ryckbosch, J. P. A. M. de André, Thomas Kintscher, G. Merino, N. Wandkowsky, J. C. Díaz-Vélez, S. Kopper, Janet Conrad, K. Jero, A. Christov, V. di Lorenzo, S. Wickmann, J. Auffenberg, D. Bindig, Jenni Adams, Dirk Lennarz, A. Steuer, Ignacio Taboada, D. Grant, D. Hebecker, H. Dujmovic, G. S. Japaridze, R. Nahnhauer, M. Quinnan, T. Meures, M. Vraeghe, A. Olivas, S. Schoenen, R. Cross, David Berley, M. Rongen, M. J. Larson, S. Bron, J. J. Beatty, C. Walck, G. Yodh, A. Burgman, D. Rysewyk, M. Börner, F. Huang, M. Song, T. L. Carver, Mike Richman, A. Bernhard, Steven W. Barwick, Juanan Aguilar, Stijn Blot, R. Hoffmann, Marjon Moulai, Chris Wendt, J. Becker Tjus, M. Bissok, J. Kunnen, K. Mase, C.-C. Fösig, E. Pinat, M. Labare, L. Gerhardt, R. Reimann, S. Tilav, Ch. Weaver, G. M. Spiczak, S. Hickford, R. Konietz, K. Rawlins, M. Vehring, G. T. Przybylski, M. van Rossem, Joeran Stettner, K. D. de Vries, T. Glüsenkamp, M. Kauer, Frank McNally, S. Westerhoff, Olga Botner, Elisa Resconi, Y. Xu, M. Rameez, Reina H. Maruyama, Joshua Hignight, James Madsen, K. Wiebe, Lu Lu, T. DeYoung, M. Zoll, Maryon Ahrens, K. Helbing, D. Heereman, H. Niederhausen, Francis Halzen, M. Dunkman, E. Unger, M. Medici, S. Coenders, E. Woolsey, G. Binder, Delia Tosi, S. Ter-Antonyan, R. Ström, Won Nam Kang, M. N. Tobin, Konstancja Satalecka, Theo Glauch, I. Ansseau, J. Lünemann, G. Neer, Teresa Montaruli, Elisa Bernardini, Timo Karg, M. Lesiak-Bzdak, Christian Spiering, E. Blaufuss, A. Terliuk, J. C. Gallagher, H. Dembinski, K. Krings, T. O. B. Schmidt, M. G. Aartsen, Klas Hultqvist, J. Kiryluk, S. C. Nowicki, Kendall Mahn, F. Bos, K. Andeen, S. De Ridder, Justin Vandenbroucke, Anna Franckowiak, Allan Hallgren, R. C. Bay, T. Anderson, C. De Clercq, M. Leuermann, Kurt Woschnagg, S. Yoshida, P. A. Toale, L. Brayeur, T. Hansmann, Karim Ghorbani, M. Casier, Spencer Axani, W. Giang, J. L. Lanfranchi, M. Archinger, T. Ehrhardt, C. Haack, Michael Sutherland, J. Tatar, S. Mancina, Carlos Arguelles, X. W. Xu, U. Naumann, M. Meier, N. Kurahashi, Todor Stanev, R. Hellauer, M. Jeong, G. de Wasseige, M. Tselengidou, Thomas K. Gaisser, P. Desiati, M. Mandelartz, F. Lauber, Lisa Johanna Schumacher, Javier Gonzalez, Giorgio Maggi, David A. Williams, Markus Ackermann, Carsten Rott, Alexander Kappes, Kirill Filimonov, Uli Katz, Segev BenZvi, A. Wallace, J. Sandroos, D. Altmann, S. Toscano, Spencer Klein, D. F. Cowen, L. Classen, Kara Hoffman, T. Ruhe, D. Pieloth, M. Kroll, Wolfgang Rhode, B. J. Whelan, S. In, L. Wills, Ali Kheirandish, T. Fuchs, L. Sabbatini, Takao Kuwabara, K. Clark, K. Hoshina, Stijn Vanheule, Philipp Eller, A. Sandrock, J. Felde, J. P. Yanez, H. Pandya, Xinhua Bai, A. Obertacke Pollmann, S. Kunwar, J. L. Kelley, M. Wallraff, Markus Ahlers, L. Rädel, R. G. Stokstad, A. Goldschmidt, S. E. Sanchez Herrera, E. Cheung, M. Usner, Elizabeth Friedman, R. Maunu, N. L. Strotjohann, Z. Griffith, Min Suk Kim, Donglian Xu, P. B. Price, G. Tešić, E. del Pino Rosendo, Subir Sarkar, Tobias Menne, S. Seunarine, Bron, Stéphanie, Carver, Tessa, Christov, Asen, Montaruli, Teresa, and Rameez, Mohamed
Subjects: background [atmosphere], Particle physics, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, lcsh:Astrophysics, ddc:500.2, 01 natural sciences, Signal, horizon, IceCube, Subatomär fysik, 0103 physical sciences, lcsh:QB460-466, Subatomic Physics, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, ddc:530, atmosphere [muon], 010306 general physics, detector [neutrino], mass [WIMP], Engineering (miscellaneous), Computer Science::Databases, direct detection [dark matter], Physics, Muon, 010308 nuclear & particles physics, scattering, sensitivity, statistics, lcsh:QC770-798, High Energy Physics::Experiment, Neutrino
Abstract: The European physical journal / C Particles and fields C 79(3), 214 (2019). doi:10.1140/epjc/s10052-019-6702-y, Published by Springer24928, Heidelberg
Published: 2019
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49. Searching for High-Energy Neutrino Emission from TeV Pulsar Wind Nebulae

Author: Qinrui Liu and Ali Kheirandish
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), High energy, Astrophysics::High Energy Astrophysical Phenomena, Hadron, High Energy Physics::Phenomenology, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Galactic plane, Pulsar, High Energy Physics::Experiment, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract: Pulsar wind nebulae (PWNe) are main gamma-ray emitters in the Galactic plane. Although the leptonic scenario is able to explain most PWNe emission well, a hadronic contribution cannot be excluded. High-energy emission raises the possibility that gamma-rays are hadronically produced which inevitably leads to the production of neutrinos. We report a stacking analysis to search for neutrino emission from 35 PWNe that are very-high-energy gamma-ray emitters and the results using 9.5 years of all-sky IceCube data. In the absence of any significant correlation, we set upper limits on the total neutrino emission from those PWNe and constraints on the hadronic component., Comment: Presented at the 36th International Cosmic Ray Conference (ICRC 2019). See arXiv:1907.11699 for all IceCube contributions
Published: 2019
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50. Time-integrated Neutrino Source Searches with 10 years of IceCube Data

Author: Federica Bradascio, Alexander Burgman, Merlin Schaufel, Daria Pankova, E. Friedman, Claudio Kopper, Subir Sarkar, Chad Finley, J. J. Beatty, Tianlu Yuan, M. Kauer, D. Kang, Christoph Tönnis, Frank G. Schröder, Alexander Fritz, D. Z. Besson, K. Mase, Yuya Makino, R. Morse, Suyong Choi, I. Taboada, R. Maunu, David Kappesser, Michael O. Wolf, Minjin Jeong, Thomas Meures, N. L. Strotjohann, Felix Henningsen, A. R. Fazely, E. Pinat, Simona Toscano, P. Heix, K. Jero, Sander Vanheule, N. Kurahashi, Karl J. Clark, S. De Ridder, Z. Griffith, Jenni Adams, J. Lünemann, C. Pérez de los Heros, A. Obertacke Pollmann, Aswathi Balagopal, Saskia Philippen, D. Rysewyk, M. Song, T. L. Carver, Mike Richman, J. L. Kelley, Markus Ahlers, K. Meagher, F. McNally, M. J. Weiss, M. Labare, T. Palczewski, C. Wendt, E. O’Sullivan, S. Hickford, Jan Soedingrekso, M. Stamatikos, S. Kopper, René Reimann, A. O'Murchadha, Lenka Tomankova, Chunfai Tung, P. Peiffer, M. J. Larson, Pranav Dave, Timothyblake Watson, Erik Ganster, T. Menne, G. de Wasseige, B. Eberhardt, A. Stößl, L. Rauch, Benjamin Hokanson-Fasig, Yang Lyu, Samvel Ter-Antonyan, M. Silva, R. G. Stokstad, B. Relethford, S. Yoshida, Won Nam Kang, Amirreza Raissi, Chris Weaver, Stephanie Bron, Max Renschler, D. J. Koskinen, Wing Yan Ma, Tim Ruhe, B. J. P. Jones, R. Hoffmann, B. J. Whelan, X. Bai, G. Neer, E. Bourbeau, C. J. Lozano Mariscal, G. Merino, Reina H. Maruyama, James DeLaunay, C. Alispach, G. Krückl, Konstancja Satalecka, N. Wandkowsky, H. Dujmovic, Janet Conrad, K. Wiebe, Marjon Moulai, Summer Blot, Andres Medina, Theo Glauch, Jan Weldert, Thomas Ehrhardt, Spencer Griswold, Steven Robertson, Joshua Hignight, L. Halve, Philipp Eller, Shefali Shefali, D. Mockler, M. Günder, Alejandro Diaz, R. Cross, Timo Sturwald, H. Niederhausen, Kael Hanson, Surujhdeo Seunarine, R. Snihur, A. Weindl, Maria Tselengidou, D. Soldin, Johannes Werthebach, Carsten Rott, Juanan Aguilar, T. Stezelberger, R. Joppe, D. van Eijk, Joshua A. Wood, J. Felde, C. Walck, Jeffrey Lazar, R. Hellauer, J. Buscher, P. Schlunder, Maryon Ahrens, Alan Coleman, William Luszczak, Alexander Sandrock, Frederik Tenholt, R. Nagai, A. Goldschmidt, L. Schumacher, M. Zöcklein, Xianwu Xu, M. Medici, J. Sandroos, Timo Karg, T. Stanev, Maximilian Meier, Thomas K. Gaisser, G. B. Yodh, P. Steinmüller, F. Huang, G. H. Collin, Matthias Vraeghe, J. Stettner, J. Kim, Delia Tosi, U. Katz, Mehmet Gunduz, Agnieszka Leszczyńska, M. E. Huber, Marcos Santander, Paolo Desiati, S. E. Sanchez Herrera, R. C. Bay, K. D. de Vries, Sebastian Baur, Sebastian Böser, P. Backes, Gisela Anton, Elisa Bernardini, G. W. Sullivan, H. S. Matis, D. B. Fox, L. Gerhardt, A. Olivas, Austin Schneider, James E. Braun, N. van Eijndhoven, K. Helbing, C. Haack, Juan Carlos Diaz-Velez, H. Bagherpour, Benjamin Bastian, Anastasia Maria Barbano, T. Kittler, Daniel Bindig, Hermann Kolanoski, K. Becker, Emily Dvorak, N. Kulacz, Olga Botner, Kayla Leonard, D. R. Nygren, Javier Gonzalez, Roxanne Turcotte, Marek Kowalski, D. Hebecker, F. Jonske, Alexander Trettin, Giorgio Maggi, Mirco Hunnefeld, Marie Oehler, V. Baum, Sarah Mancina, Anna Franckowiak, Tobias Hoinka, Francis Halzen, J. Auffenberg, M. Börner, Steve Sclafani, J. Kiryluk, C. De Clercq, S. Tilav, I. Ansseau, Paul Coppin, Andrea Turcati, J. C. Gallagher, M. Leuermann, K. Andeen, Elisa Lohfink, J. P. Yanez, Gerrit Wrede, K. Hoshina, Thomas Huber, David A. Williams, Allan Hallgren, Juliana Stachurska, J. van Santen, H. Dembinski, Alex Pizzuto, Markus Ackermann, Glenn Spiczak, G. Momenté, M. G. Aartsen, Pablo Correa, S. W. Barwick, M. Rameez, D. F. Cowen, Gary Binder, Gerald Przybylski, U. Naumann, R. Halliday, George Japaridze, Roger Moore, E. Unger, A. Kyriacou, J. Bourbeau, K. Krings, Seongjin In, Elisa Resconi, Yiqian Xu, Matt Dunkman, Alessio Porcelli, M. Plum, J. Becker Tjus, E. Cheung, Ramesh Koirala, Thomas Stuttard, Dirk Ryckbosch, Stephan Meighen-Berger, K. Tollefson, E. Blaufuss, Albrecht Karle, Qinrui Liu, T. Glüsenkamp, L. Classen, Martina Karl, Jochen M. Schneider, M. A. Unland Elorrieta, D. Heereman, M. Wallraff, A. Steuer, Raamis Hussain, Colin Turley, T. Anderson, Immacolata Carmen Rea, Andreas Haungs, A. Ishihara, K. Mallot, H. Schieler, Kirill Filimonov, Segev BenZvi, T. Kintscher, M. Usner, Frederik Hermann Lauber, Spencer Klein, A. Terliuk, Justin Lanfranchi, Kara Hoffman, Julia Böttcher, Christian Spiering, Hershal Pandya, Wolfgang Rhode, Robert Stein, Justin Vandenbroucke, L. Wills, P. Muth, Ioana Codrina Maris, S. C. Nowicki, Christian Bohm, Ibrahim Safa, Damian Pieloth, Ali Kheirandish, W. Van Driessche, Nahee Park, K. Hultqvist, Darren Grant, Jannes Brostean-Kaiser, Christoph Raab, Nadège Iovine, M. U. Nisa, L. Köpke, D. Berley, G. C. Hill, Bunheng Ty, Ralph Engel, Giovanni Renzi, K. Rawlins, D. Seckel, S. Fahey, Tyce DeYoung, Nathan Whitehorn, Martin Rongen, R. S. Busse, Christopher Wiebusch, Kunal Deoskar, James Madsen, Lu Lu, L. Wille, Teresa Montaruli, Kendall Mahn, P. B. Price, Francesco Lucarelli, T. O. B. Schmidt, C. Chen, Karim Ghorbani, Spencer Axani, T. R. Wood, Carlos Arguelles, Jessie Micallef, P. Mallik, Kurt Woschnagg, Paul Evenson, Simone Garrappa, Dmitry Chirkin, Alexander Kappes, A. Wallace, Da Xu, Physics, Faculty of Sciences and Bioengineering Sciences, Elementary Particle Physics, and Vriendenkring VUB
Subjects: background [atmosphere], Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, General Physics and Astronomy, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, IceCube, particle source [neutrino], TRACK RECONSTRUCTION, 0103 physical sciences, ddc:530, atmosphere [muon], 010306 general physics, Astrophysics::Galaxy Astrophysics, media_common, astro-ph.HE, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Muon, Astrophysics::Instrumentation and Methods for Astrophysics, Northern Hemisphere, Astronomy, Galaxy, messenger, Physics and Astronomy, Sky, correlation, time dependence, upgrade, galaxy, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, statistical
Abstract: Physical review letters 124(5), 051103 (1-9) (2020). doi:10.1103/PhysRevLett.124.051103, This paper presents the results from point-like neutrino source searches using ten years of IceCube data collected between April 6, 2008 and July 10, 2018. We evaluate the significance of an astrophysical signal from a point-like source looking for an excess of clustered neutrino events with energies typically above $\sim1\,$TeV among the background of atmospheric muons and neutrinos. We perform a full-sky scan, a search within a selected source catalog, a catalog population study, and three stacked Galactic catalog searches. The most significant point in the Northern hemisphere from scanning the sky is coincident with the Seyfert II galaxy NGC 1068, which was included in the source catalog search. The excess at the coordinates of NGC 1068 is inconsistent with background expectations at the level of $2.9\,\sigma$ after accounting for statistical trials. The combination of this result along with excesses observed at the coordinates of three other sources, including TXS 0506+056, suggests that, collectively, correlations with sources in the Northern catalog are inconsistent with background at 3.3$\,\sigma$ significance. These results, all based on searches for a cumulative neutrino signal integrated over the ten years of available data, motivate further study of these and similar sources, including time-dependent analyses, multimessenger correlations, and the possibility of stronger evidence with coming upgrades to the detector., Published by APS, College Park, Md.
Published: 2019
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