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7 results on '"Ali Abduh"'

1. A New Sarcoma Shortly after Treatment for High-Grade Glioma with Adjuvant Chemoradiation: A Case Report

Author

Abdossalam M. Madkhali, Hasah F. Alaluan, Mohammed H. Alnajeim, Eyad F. Al Saeed, Abdulrazag M. Ajlan, Ahmed Abdelwarith, Ali Abduh, Saleh Albanyan, Ashwag Alqurashi, and Hisham Alkhalidi

Subjects
sarcoma, high-grade glioma, glioblastoma, radiation, complication, secondary cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: High-grade gliomas are central nervous system tumors conventionally treated with surgery followed by adjuvant chemoradiotherapy. Secondary cancer due to radiation therapy is a rare yet established phenomenon that typically occurs years after radiation therapy. Case Presentation: In this case, we discuss an early presentation of a second cancer adjacent to the radiation field. This case report is of a 52-year-old male who developed a new scalp sarcoma at the site of primary surgery 8 months after radiation therapy. Genetic testing revealed a heterozygous missense variant in the NF1 gene, a variant of uncertain significance. The report highlights that this case does not conform to the expected criteria for postradiation sarcoma in terms of timing. Conclusion: Secondary cancers may arise earlier than expected, even in phenotypically normal patients, as they may have unmanifested variants of relevant mutations. The question of pre-radiotherapy screening for radiosensitivity syndromes and diseases requires further study, as current data are limited and do not provide enough insight into the significance of different genetic variants.

Published
2024
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7. Spectrophotometric Determination of Diazepam in Pharmaceutical Forms by Ion-Pairing with Ferrithiocyanide Complex

Author

Ali Abduh Mutair, Niyazi Abdulmawla Sallam Al-Areqi, and Pulikkal Ajmal Koya

Subjects
Reproducibility, Accuracy and precision, Chromatography, medicine.diagnostic_test, Chemistry, Ion pairing, Significant difference, Analytical chemistry, General Medicine, Repeatability, High-performance liquid chromatography, Dosage form, Spectrophotometry, medicine
Abstract

A rapid and validated spectrophotometric method has been developed for determination of Diazepam (DZP) in pure and pharmaceutical dosage forms. The method was based on ion-pair association reaction of DZP with ferrithiocyanide complex in acidic medium. The color development was monitored spectrophometrically at the maximum absorption, λmax = 506 nm. The stoichiometry of the ion-pair associate was determined, and the reaction path way was postulated. The proposed method was successfully applied to the determination of DZP in five marketed brands with three labeled dosages; 2, 5, 10 mg per tablet. The analytical results of the proposed spectrophotometric method were statistically compared with those obtained from standard HPLC procedures used as a reference method. Application of the proposed procedure shows acceptable linearity, precision, repeatability, and reproducibility. The analytical results were in good agreement with the label claims. F-and Student’s t-tests proved that no significant difference regarding both accuracy and precision between the proposed and reference method, and that this spectrophotometric method can be employed for the routine analysis of DZP in bulks as well as in the commercial formulations.

Published
2016

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