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Background: Regular eye care is important nursing intervention for effective clinical management of critically ill patients. Eye care can prevent dryness, damage to the eye, complications and infection. This study aims to: Evaluate clinical Outcomes of Implementing Evidence Based Eye Care Intervention for Mechanically Ventilated Patients. Design: Design of quasi-experimental research. This research was conducted in the Intensive Care Units of Assiut University Hospital. Subjects: This study included sixty recently admitted adult mechanically ventilated patients. Purposive sampling was taken in accordance with the inclusion criteria. Three tools were used to collect study data. Tool I: Patient assessment sheet. Tool II: Evidence Based Eye Care Intervention tool. Tool III: Clinical outcomes of implementing evidence based eye care intervention tool. Method: The evidence based eye care intervention for the study group was implemented and evaluated the occurrence of ocular surface disorders by using a fluorescein eye stain test. Results: A total of sixty patients. The outcomes revealed a significant reduction in the presence of ocular surface disorders after implementing an adult eye care intervention. Related to the right cornea, the results revealed P<0001 on the 5th day, while on the left cornea, the results revealed P = 0.015 on the 7th day. Regarding conjunctiva, the present finding showed P <0001 for both eyes on the 7th day. Conclusion: Implementing an evidence based eye care intervention diminished the occurrence of ocular surface disorders among mechanically ventilated patients. Recommendation: Regular and necessary eye care can lower the risk of eye complications and infection. [ABSTRACT FROM AUTHOR]