3,364 results on '"Ali, O."'
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2. Generation of Chemically Active Species in Hydrogen Peroxide (H2O2) Discharge Plasma and Their Role in the Eradication of Microorganisms
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Khan, Ali Akbar, Khattak, N. A. D., Khalid, Muhammad, Alyousef, Haifa A., Al-Ghamdi, Ali O., and El-Tantawy, S. A.
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- 2024
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3. Groundwater recharge potential zone modeling in the Wadi Al-Lith Basin, Saudi Arabia
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Kawara, Atef Q., Elsebaie, Ibrahim H., and Alnahit, Ali O.
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- 2024
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4. Solar Photovoltaic Thermal Collector as a Cogeneration Energy System: Conception and Recent Development in the Mediterranean Region
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Hmida, A., Slimani, M. E. A., El Haj Assad, M., Ben Ali, O., de Boer, Jacob, Editorial Board Member, Barceló, Damià, Series Editor, Kostianoy, Andrey G., Series Editor, Garrigues, Philippe, Editorial Board Member, Gu, Ji-Dong, Editorial Board Member, Hutzinger, Otto, Founding Editor, Jones, Kevin C., Editorial Board Member, Negm, Abdelazim, Editorial Board Member, Newton, Alice, Editorial Board Member, Nghiem, Duc Long, Editorial Board Member, Garcia-Segura, Sergi, Editorial Board Member, Verlicchi, Paola, Editorial Board Member, Wagner, Stephan, Editorial Board Member, Rocha-Santos, Teresa, Editorial Board Member, Picó, Yolanda, Editorial Board Member, Henni, Abdellah, editor, and Zerrouki, Djamal, editor
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- 2024
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5. Experimental and Performance Evaluation of the Soiling and Cooling Effect on the Solar Photovoltaic Modules
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Chaudhary, Tariq Nawaz, Maka, Ali O. M., Saleem, Muhammad Wajid, Ahmed, Nadeem, Rehman, Muneeb Ur, and Azeem, Muhammad Umer
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- 2024
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6. Preparation of a Novel Magnetic Nanocatalyst with High Efficiency for the Knoevenagel Condensation Reaction in Green Conditions
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Ali, O. M., Mohammadali, P., Siamak, A., and Nayer, M. T.
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- 2023
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7. Modulation of inflammatory, oxidative, and apoptotic stresses mediates the renoprotective effect of daidzein against glycerol-induced acute kidney injury in rats
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Kassab, Rami B., Elhenawy, Ahmed A., AbdulrahmanTheyab, Hawsawi, Yousef M., Al-Amer, Osama M., Oyouni, Atif Abdulwahab A., Habotta, Ola A., Althagafi, Hussam A., Alharthi, Fahad, Lokman, Maha S., Alsharif, Khalaf F., Albrakati, Ashraf, Al-Ghamdy, Ali O., Elmahallawy, Ehab Kotb, Elhefny, Mohamed A., Hassan, Kalid E., Albarakati, Alaa Jameel A., Abdel Moneim, Ahmed E., and Moustafa, Ahmed A.
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- 2023
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8. Comparison of anthracycline-containing and anthracycline-free regimens in neoadjuvant HER-2 positive breast cancer treatment
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Murat Bardakci, Hilal Karakas, Dogan Bayram, Nilufer Avci, Sait Kitapli, Mirac Ozen, Ferit Aslan, Caglar Koseoglu, Ahmet Kadioglu, Ilknur D. Onur, Teoman Sakalar, Mahmut Buyuksimsek, Ali Alkan, Yakup Ergun, Ali O. Kaya, Burak Bilgin, and Bulent Yalcin
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Medicine ,Science - Abstract
Abstract While some clinics have adopted abbreviated neoadjuvant treatment for HER2-positive breast cancer, there remains a shortage of comprehensive clinical data to support this practice. This is a retrospective, multicenter study. A total of 142 patients were included in the study who are HER2-positive breast cancer, aged ≤ 65 years, with left ventricular ejection fraction ≥ 50%, received neoadjuvant chemotherapy and underwent surgery at 10 different oncology centers in Türkiye between October 2016 and December 2022. The treatment arms were divided into 4–6 cycles of docetaxel/trastuzumab/pertuzumab for arm A, 4 cycles of adriamycin/cyclophosphamide followed by 4 cycles of taxane/TP for arm B. There were 50 patients (35.2%) in arm A and 92 patients (64.8%) in arm B. The median follow-up of all of the patients was 19.9 months (95% CI 17.5–22.3). The 3-year DFS rates for treatment arms A and B were 90.0% and 83.8%, respectively, and the survival outcomes between the groups were similar (p = 0.34). Furthermore, the pathologic complete response rates were similar in both treatment arms, at 50.0% and 51.1%, respectively (p = 0.90). This study supports shortened neoadjuvant treatment of HER2-positive breast cancer, a common practice in some clinics.
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- 2024
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9. Groundwater recharge potential zone modeling in the Wadi Al-Lith Basin, Saudi Arabia
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Atef Q. Kawara, Ibrahim H. Elsebaie, and Ali O. Alnahit
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AHP ,GIS ,Groundwater recharge ,Al-Lith ,Saudi Arabia ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
Abstract The management of groundwater resources is crucial in arid and semi-arid regions such as Al-Lith Basin, and therefore, the identification of suitable areas for groundwater recharge is important in solving the problem of water scarcity and ensuring the long-term sustainability of aquifers. In this study, the Analytic Hierarchy Process (AHP) technique, in conjunction with GIS, was applied to locate potential zones for groundwater recharge in the Al-Lith basin. The research methodology includes collecting the essential data, including lineament density, slope, rainfall, drainage density, LU/LC, soil, elevation, and TWI. AHP is used to assign relative weights to different qualities, considering their significance in influencing groundwater recharge. The ArcGIS was employed to process and analyze the weighted layers, which resulted in the creation of a comprehensive map illustrating the potential for groundwater recharge. The study results suggested that the Al-Lith Subbasin has several zones that exhibit different levels of groundwater recharge capability. The results obtained from this study indicated that 12.83% of the basin area has significant groundwater recharge potential zones (GWPZ), ranging from high to very high levels. The groundwater recharge potential zones in the basin are categorized as very poor to poor, covering 19.4% of the area, while the moderate groundwater recharge potential zones represent 67.77% of the basin area. The groundwater protection zones were validated using 19 wells distributed across the basin. The validation findings indicate there is an overlap between the GWPZ classes and the wells in the specified location. Overall, the findings of this study can enhance groundwater resource management and inform policy development for targeted interventions aimed at enhancing groundwater recharge.
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- 2024
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10. Beam test results of 25 $\mu$m and 35 $\mu$m thick FBK UFSD]{Beam test results of 25 $\mu$m and 35 $\mu$m thick FBK ultra fast silicon detectors
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Carnesecchi, F., Strazzi, S., Alici, A., Arcidiacono, R., Borghi, G., Boscardin, M., Cartiglia, N., Vignali, M. Centis, Cavazza, D., Betta, G. -F. Dalla, Durando, S., Ferrero, M., Ficorella, F., Ali, O. Hammad, Mandurrino, M., Margotti, A., Menzio, L., Nania, R., Pancheri, L., Paternoster, G., Scioli, G., Siviero, F., Sola, V., Tornago, M., and Vignola, G.
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Physics - Instrumentation and Detectors - Abstract
This paper presents the measurements on first very thin Ultra Fast Silicon Detectors (UFSDs) produced by Fondazione Bruno Kessler; the data have been collected in a beam test setup at the CERN PS, using beam with a momentum of 12 GeV/c. UFSDs with a nominal thickness of 25 $\mu$m and 35 $\mu$m and an area of 1 $\times$ 1 $\text{mm}^2$ have been considered, together with an additional HPK 50-$\mu$m thick sensor, taken as reference. Their timing performances have been studied as a function of the applied voltage and gain. A time resolution of about 25 ps and of 22 ps at a voltage of 120 V and 240 V has been obtained for the 25 and 35 $\mu$m thick UFSDs, respectively.
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- 2022
11. Methylene blue-assisted molecularly-imprinted film modified nitrogen and sulfur co-doped molybdenum carbide for simultaneous electrochemical determination of two hepatotoxic drugs
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Alqarni, Ali O., Mahmoud, Ashraf M., Alyami, Bandar A., Ali, Ramadan, and El-Wekil, Mohamed M.
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- 2024
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12. Comparative Physiological, Biochemical, and Leaf Proteome Responses of Contrasting Wheat Varieties to Drought Stress
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Sellwane J. Moloi, Ali O. Alqarni, Adrian P. Brown, Tatenda Goche, Nemera G. Shargie, Makoena J. Moloi, Arun Gokul, Stephen Chivasa, and Rudo Ngara
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Triticum aestivum ,drought ,proline ,oxidative stress ,lipid peroxidation ,antioxidant enzymes ,Botany ,QK1-989 - Abstract
Drought stress severely affects crop productivity and threatens food security. As current trends of global warming are predicted to exacerbate droughts, developing drought-resilient crops becomes urgent. Here, we used the drought-tolerant (BW35695) and drought-sensitive (BW4074) wheat varieties to investigate the physiological, biochemical, and leaf proteome responses underpinning drought tolerance. In response to drought, the tolerant variety had higher osmolyte accumulation and maintained higher leaf water content than the sensitive variety. BW35695 also had an enhanced antioxidant enzyme capacity and reduced reactive oxygen species (ROS), resulting in diminished membrane lipid damage, as reflected by malondialdehyde content. Proteomic analysis revealed that drought-induced differential expression of proteins involved in diverse biological processes in both wheat varieties, including primary and secondary metabolism, protein synthesis/folding/degradation, defense/ROS detoxification, energy, transcription, and cell structure. Notably, photosynthesis emerged as the most enriched biochemical process targeted for suppression in the drought-tolerant BW35695 wheat, but not in drought-sensitive BW4074, possibly as a survival strategy for averting cell damage inflicted by photosynthesis-derived ROS. Additionally, protein synthesis-related proteins were highly upregulated in BW35695, presumably to drive cell-wide stress-adaptive responses. The protein network identified here will be useful in further studies to understand the molecular basis for divergent drought response phenotypes in crops.
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- 2024
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13. Epiretinal membrane formation with a pseudohole appearance ın a case with straatsma syndrome
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Barbaros Hayrettin Ünlü, Eda Hümaz, and Ali O. Saatci
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Ophthalmology ,RE1-994 - Published
- 2024
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14. Conceptions of Professionalism in U.S. Research Universities: Evidence from the gradSERU Survey
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Brint, Steven and Ilhan, Ali O.
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Recent scholars of the professions have argued that a new hybrid form of professionalism is becoming dominant. This new form combines traditional commitments to ethics and community service with new commitments to managerial and entrepreneurial objectives. We analyze the perceptions of 4,300 U.S. graduate students in 21 fields concerning how well their programs have prepared them for leadership and management and for ethics and community service. These assessments allow us to examine the prevalence of this new conception of professionalism and to examine it in relation to two other conceptions: the "neo-classical" emphasis on ethics and community service as opposed to leadership and management, and another that emphasizes a divergence between business and technical professions on one side and social and cultural professions on the other. Hybridization was comparatively rare but occurred more frequently among students preparing for management, law, and medicine, and among men and students from more affluent families. We also find some support for the neo-classical thesis insofar as students tended to score higher on the ethics and community measure than on the leadership and management measure. However, the largest number of students took positions consistent with the divergence thesis.
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- 2022
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15. The second production of RSD (AC-LGAD) at FBK
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Mandurrino, M., Arcidiacono, R., Bisht, A., Borghi, G., Boscardin, M., Cartiglia, N., Vignali, M. Centis, Betta, G. -F. Dalla, Ferrero, M., Ficorella, F., Ali, O. Hammad, Rojas, A. D. Martinez, Menzio, L., Pancheri, L., Paternoster, G., Siviero, F., Sola, V., and Tornago, M.
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Physics - Instrumentation and Detectors - Abstract
In this contribution we describe the second run of RSD (Resistive AC-Coupled Silicon Detectors) designed at INFN Torino and produced by Fondazione Bruno Kessler (FBK), Trento. RSD are n-in-p detectors intended for 4D particle tracking based on the LGAD technology that get rid of any segmentation implant in order to achieve the 100% fill-factor. They are characterized by three key-elements, (i) a continuous gain implant, (ii) a resistive n-cathode and (iii) a dielectric coupling layer deposited on top, guaranteeing a good spatial reconstruction of the hit position while benefiting from the good timing properties of LGADs. We will start from the very promising results of our RSD1 batch in terms of tracking performances and then we will move to the description of the design of the RSD2 run. In particular, the principles driving the sensor design and the specific AC-electrode layout adopted to optimize the signal confinement will be addressed.
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- 2021
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16. The first batch of compensated LGAD sensors
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Sola, V., Paternoster, G., Morozzi, A., Arcidiacono, R., Barozzi, M., Borghi, G., Boscardin, M., Cartiglia, N., Centis Vignali, M., Costa, M., Croci, T., Ferrero, M., Fondacci, A., Ficorella, F., Giordanengo, S., Hammad Ali, O., Hanna, C., Lanteri, L., Menzio, L., Moscatelli, F., Passeri, D., Pastrone, N., Siviero, F., and White, R.S.
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- 2024
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17. Measurements and TCAD simulations of innovative RSD and DC-RSD LGAD devices for future 4D tracking
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Moscatelli, F., Fondacci, A., Arcidiacono, R., Boscardin, M., Cartiglia, N., Vignali, M. Centis, Croci, T., Ferrero, M., Ali, O. Hammad, Lanteri, L., Losana, A., Menzio, L., Monaco, V., Mulargia, R., Passeri, D., Paternoster, G., Siviero, F., Sola, V., and Morozzi, A.
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- 2024
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18. Three-dimensional mixed-mode stress intensity factor solutions for inclined surface cracks in plate structures subjected to uniaxial and biaxial uniform tensile loading
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Şahin, Hakan, Ayhan, Ali O., and Yaren, M. Faruk
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- 2024
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19. A new method for prediction of fatigue crack propagation life under variable amplitude spectrum loading
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Yaren, Mehmet F. and Ayhan, Ali O.
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- 2024
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20. Ratiometric fluorometric determination of sulfide using graphene quantum dots and self-assembled thiolate-capped gold nanoclusters triggered by aluminum
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Alyami, Bandar A., Mahmoud, Ashraf M., Alqarni, Ali O., Ali, Al-Montaser Bellah H., and El-Wekil, Mohamed M.
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- 2023
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21. Retraction Note: TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT
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Hill, Richard, Madureira, Patricia A., Ferreira, Bibiana, Baptista, Inês, Machado, Susana, Colaҫo, Laura, dos Santos, Marta, Liu, Ningshu, Dopazo, Ana, Ugurel, Selma, Adrienn, Angyal, Kiss-Toth, Endre, Isbilen, Murat, Gure, Ali O., and Link, Wolfgang
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- 2023
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22. Oral contraceptive pills shortage in Lebanon amidst the economic collapse: a nationwide exploratory study
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Itani, Rania, Khojah, Hani MJ, Karout, Samar, Abu-Farha, Rana, Mukattash, Tareq L., Rahme, Deema, Housary, Khouloud, Achi, Hiam El, Safar, Ali O., Al Hajj, Ismail Karam, and El-Lakany, Abdalla
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- 2023
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23. Activity of (η6-arene)dichloridoruthenium(II) complexes with antifungal imidazolyl-based ligands against Toxoplasma gondii and Leishmania major
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Al Nasr, Ibrahim S., Daoud, Ismail, Koko, Waleed S., Khan, Tariq A., Schobert, Rainer, Ben Said, Ridha, Amdouni, Noureddine, Rahali, Seyfeddine, Al-Ghamdi, Ali O., and Biersack, Bernhard
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- 2024
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24. A reliable and selective ratiometric sensing probe for fluorometric determination of P2O74− based on AIE of GSH@CuNCs-assisted by Al-N@CQDs
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Mahmoud, Ashraf M., Abu-Alrub, Samer S., Al-Qarni, Ali O., El-Wekil, Mohamed M., and Shahin, Reem Y.
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- 2024
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25. First report for fluorometric determination of kasugamycin based on amino acid-functionalized bimetallic nanoclusters
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Mahmoud, Ashraf M., Abu-Alrub, Samer S., Al-Qarni, Ali O., Alyami, Bandar A., El-Wekil, Mohamed M., and Oraby, Mohamed
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- 2024
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26. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmad, M, Ahmed, N, Ahmed, O, Ahmed, R, Ahmad, S, Ahmed, S H, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, A, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Alegria, A, Alexander, C, Alexander, J, Alexander, P, Al-Fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, F, Ali, J, Ali, M, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Aliyuda, F, Alizaedeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsup, D, Allsop, H, Allsop, L, Almahroos, A, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Ames, K, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amosun, V, Amsal, M, Amsha, K, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, S, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, W, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Anstey, P, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonnia, Z, Anu, V, 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Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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27. A risk-adjustment model for patients presenting to hospitals with out-of-hospital cardiac arrest and ST-elevation myocardial infarction
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Tran, Andy T, Hart, Anthony J, Spertus, John A, Jones, Philip G, McNally, Bryan F, Malik, Ali O, and Chan, Paul S
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Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Cardiovascular ,Heart Disease ,Heart Disease - Coronary Heart Disease ,Good Health and Well Being ,Adult ,Cardiopulmonary Resuscitation ,Coronary Angiography ,Female ,Hospitals ,Humans ,Male ,Out-of-Hospital Cardiac Arrest ,Percutaneous Coronary Intervention ,Registries ,ST Elevation Myocardial Infarction ,STEMI ,Cardiac arrest ,Risk adjustment ,Mortality ,Angiography ,Outcomes ,Nursing ,Public Health and Health Services ,Emergency & Critical Care Medicine ,Clinical sciences ,Public health - Abstract
BackgroundPatients with ST-elevation myocardial infarction (STEMI) complicated by an out-of-hospital-cardiac-arrest (OHCA) may vary widely in their probability of dying. Large variation in mortality may have implications for current national efforts to benchmark operator and hospital mortality rates for coronary angiography. We aimed to build a risk-adjustment model of in-hospital mortality among OHCA survivors with concurrent STEMI.MethodsWithin the Cardiac Arrest Registry to Enhance Survival (CARES), we included adults with OHCA and STEMI who underwent emergent angiography within 2 hours of hospital arrival between January 2013 and December 2019. Using multivariable logistic regression to adjust for patient and cardiac arrest factors, we developed a risk-adjustment model for in-hospital mortality and examined variation in patients' predicted mortality.ResultsOf 2,999 patients (mean age 61.2 ± 12.0, 23.1% female, 64.6% white), 996 (33.2%) died during their hospitalization. The final risk-adjustment model included higher age (OR per 10-year increase, 1.50 [95% CI: 1.39-1.63]), unwitnessed OHCA (OR, 2.51 [1.99-3.16]), initial non-shockable rhythm [OR, 5.66 [4.52-7.13]), lack of sustained pulse for > 20 minutes (OR, 2.52 [1.88-3.36]), and longer resuscitation time (increased with each 10-minute interval) (c-statistic = 0.804 with excellent calibration). There was large variability in predicted mortality: median, 25.2%, inter-quartile-range: 14.0% to 47.8%, 10th-90th percentile: 8.2 % to 74.1%.ConclusionsIn a large national registry, we identified 5 key predictors for mortality in patients with STEMI and OHCA and found wide variability in mortality risk. Our findings suggest that current national benchmarking efforts for coronary angiography, which simply adjusts for the presence of OHCA, may not adequately capture patient case-mix severity.
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- 2022
28. Intrapleural Fibrinolytic Interventions for Retained Hemothoraces in Rabbits
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Christian J. De Vera, Jincy Jacob, Krishna Sarva, Sunil Christudas, Rebekah L. Emerine, Jon M. Florence, Oluwaseyi Akiode, Tanvi V. Gorthy, Torry A. Tucker, Karan P. Singh, Ali O. Azghani, Andrey A. Komissarov, Galina Florova, and Steven Idell
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fibrinolysins ,retained hemothorax ,pleural disease ,single-chain urokinase plasminogen activator (scuPA) ,single-chain tissue plasminogen activator (sctPA) ,plasminogen activator inhibitor-1 (PAI-1) ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Bleeding within the pleural space may result in persistent clot formation called retained hemothorax (RH). RH is prone to organization, which compromises effective drainage, leading to lung restriction and dyspnea. Intrapleural fibrinolytic therapy is used to clear the persistent organizing clot in lieu of surgery, but fibrinolysin selection, delivery strategies, and dosing have yet to be identified. We used a recently established rabbit model of RH to test whether intrapleural delivery of single-chain urokinase (scuPA) can most effectively clear RH. scuPA, or single-chain tissue plasminogen activator (sctPA), was delivered via thoracostomy tube on day 7 as either one or two doses 8 h apart. Pleural clot dissolution was assessed using transthoracic ultrasonography, chest computed tomography, two-dimensional and clot displacement measurements, and gross analysis. Two doses of scuPA (1 mg/kg) were more effective than a bolus dose of 2 mg/kg in resolving RH and facilitating drainage of pleural fluids (PF). Red blood cell counts in the PF of scuPA, or sctPA-treated rabbits were comparable, and no gross intrapleural hemorrhage was observed. Both fibrinolysins were equally effective in clearing clots and promoting pleural drainage. Biomarkers of inflammation and organization were likewise comparable in PF from both groups. The findings suggest that single-agent therapy may be effective in clearing RH; however, the clinical advantage of intrapleural scuPA remains to be established by future clinical trials.
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- 2024
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29. Neuroprotective Effects of Glycyrrhiza glabra Total Extract and Isolated Compounds
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Ali O. E. Eltahir, Sylvester I. Omoruyi, Tanya N. Augustine, Robert C. Luckay, and Ahmed A. Hussein
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Glycyrrhiza glabra ,licorice ,phenolic compounds ,neuroprotection ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Glycyrrhiza glabra L. is a plant commonly utilized in herbal medicine and stands out as one of the more extensively researched medicinal plants globally. It has been documented with respect to several pharmacological activities, notably, neuroprotective effects, among others. However, the neuroprotective activity of pure phenolic compounds has not been reported yet. The chromatographic of a methanolic extract yielded twenty-two compounds, viz.: naringenin 4′-O-glucoside (1), 3′,4′,7-trihydroxyflavanone (butin) (2), liquiritin (3), liquiritin apioside (4), abyssinone (5), glabrol (6), isoliquiritin (7), neoisoliquiritin (8), isoliquiritin apioside (9), licuraside (10). 3’[O], 4’-(2,2-dimethylpyrano)-3,7-dihydroxyflavanone (11), glabrocoumarin (12), glabrene (13), isomedicarpin (14), 7-hydroxy-4′-methoxyflavone (formononetin) (15), ononin (16), glycyroside (17), (3S)-7,4′-dihydroxy-2′-methoxyisoflavan (18), glabridin (19), neoliquiritin (20), 3,11-dioxooleana-1,12-dien-29-oic acid (21), and 3-oxo-18β-glycyrrhetinic acid (22). The results of the neuroprotection evaluation showed that G. glabra total extract (TE) and compounds 1, 7, 11, 16, and 20 protected SH-SY5Y cells by inhibiting the depletion of ATP and elevated caspase 3/7 activities induced by MPP+. Indeed, this study reports for the first time the structure and activity of compound 11 and the neuroprotective activity of some phenolic constituents from G. glabra.
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- 2024
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30. Data Wars During COVID-19 Pandemic in Turkey: Regulatory Science, Trust, Risk, and Citizen Science
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Ilhan, Ali O., Aydınoğlu, Arsev Umur, Göçoğlu, Volkan, editor, and Karkin, Naci, editor
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- 2023
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31. Diastolic Dysfunction and Health Status Outcomes After Transcatheter Aortic Valve Replacement
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El-Zein, Rayan S., Malik, Ali O., Cohen, David J., Spertus, John A., Saxon, John T., Pibarot, Philippe, Hahn, Rebecca T., Alu, Maria C., Shang, Kan, Kodali, Susheel K., Thourani, Vinod H., Leon, Martin B., Mack, Michael J., and Chhatriwalla, Adnan K.
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- 2024
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32. Sensitivity and specificity of chest ultrasound in the diagnosis of pulmonary embolism in the emergency department: A case-control study
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Hala A. Mohamed, Nadia Farouk, Emad Allam Abd Elnaeem, Mohamed T. Abdelfattah, Yosra M. Ali, and Ali O. Abdelaziz
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chest ultrasound ,md-ctpa ,pulmonary embolism ,sensitivity ,specificity ,flow signals ,color doppler ,Diseases of the respiratory system ,RC705-779 - Abstract
Objectives: The present study was designed to evaluate the role of chest ultrasound in the diagnosis of acute pulmonary embolism (PE) and determine its accuracy using multi-detector CT-pulmonary angiography (MD-CTPA) as a gold standard technique for PE diagnosis. Patients and methods: A prospective case-control study was performed with 75 patients who presented to the emergency department of Minia Cardiothoracic University Hospital with clinical suspicion of PE. All patients were evaluated clinically and by laboratory tests to assess the risk of PE. Thoracic ultrasound (TUS) was then performed for all patients for signs suggestive of PE. Finally, MD-CTPA was performed to confirm or exclude the presence of PE. Results: Patients were subdivided into two groups according to the result of MD-CTPA; group I (patients with PE) and group II (control group without PE). In our study, PE was present in the lower lobe in 75% of cases, then in the middle in 13% and in the upper lobe in 3.8% of cases. The majority of lesions in TUS were wedge-shaped lesions. No vascular flow was detected in 83% of PE-confirmed patients. The current study revealed that TUS has 81.25% sensitivity, 95% specificity, 98.3% positive predictive value, 77.2% negative predictive value and 87% accuracy in the diagnosis of PE. Univariate regression analysis revealed that the presence of wedge-shaped pleural-based lesions in grayscale US and the absence of flow signals by colour Doppler sonography (CDS) increase the possibility of PE. Wedge-shaped pleural-based lesions increase the possibility of PE by 1.48 times (P=0.0001), and the absence of flow signals by CDS increases the possibility of PE by 92.89 times (P=0.00001). Multivariate regression analysis revealed that adding absent flow signals by CDS to wedge-shaped pleural-based lesions by grayscale US increases the possibility of a PE diagnosis by 50.28 times (P=0.001). Conclusion: Chest ultrasound is a simple, safe, noninvasive, inexpensive, bedside diagnostic radiological technique that can be used in the emergency department for suspected PE or as an alternative to MD-CTPA when CTPA is contraindicated. Wedge-shaped lesions and the absence of flow signals by CDS increase the diagnostic value of ultrasound for PE.
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- 2023
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33. Diastolic Dysfunction and Health Status Outcomes After Transcatheter Aortic Valve Replacement
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Rayan S. El-Zein, DO, Ali O. Malik, MD, MSc, David J. Cohen, MD, MSc, John A. Spertus, MD, MPH, John T. Saxon, MD, Philippe Pibarot, DVM, PhD, Rebecca T. Hahn, MD, Maria C. Alu, MS, Kan Shang, PhD, Susheel K. Kodali, MD, Vinod H. Thourani, MD, Martin B. Leon, MD, Michael J. Mack, MD, and Adnan K. Chhatriwalla, MD
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Aortic stenosis ,Diastolic dysfunction ,Health status ,Transcatheter aortic valve replacement ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Baseline left ventricular diastolic dysfunction (LVDD) is associated with poor health status in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR), but health status improvement after TAVR appears similar across all grades of LVDD. Here, we aim to examine the relationship between changes in LVDD severity and health status outcomes following TAVR. Methods: Patients who underwent TAVR and had evaluable LVDD at both baseline and 1 year in the PARTNER (Placement of Aortic Transcatheter Valves) 2 SAPIEN 3 registries and PARTNER 3 trial were analyzed. LVDD grade was evaluated using echocardiography core lab data and an adapted definition of American Society of Echocardiography guidelines. Health status was assessed using the Kansas City Cardiomyopathy Questionnaire Overall Summary (KCCQ-OS) score. The association between ΔLVDD severity and ΔKCCQ-OS was examined using linear regression models adjusted for baseline KCCQ-OS. Results: Of 1100 patients, 724 (65.8%), 283 (25.7%), and 93 (8.5%) had grade 0/1, 2, and 3 LVDD at baseline, respectively. At 1 year, LVDD severity was unchanged in 790 (71.8%) patients, improved in 189 (17.2%), and worsened in 121 (11.0%). Among 376 patients with baseline grade 2 or 3 LVDD, 50.3% had improvement in LVDD. In the overall cohort, KCCQ-OS score improved by 21.9 points at 1 year. There was a statistically significant association between change in LVDD severity (improved, unchanged, and worsened) and ΔKCCQ-OS at 1 year (p = 0.007). Conclusions: Change in LVDD grade was associated with change in health status 1 year following TAVR.
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- 2024
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34. A new detector for the beam energy measurement in proton therapy: a feasibility study
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Vignati, A., Giordanengo, S., Milian, F. Mas, Ganjeh, Z. Ahmadi, Donetti, M., Fausti, F., Ferrero, M., Ali, O. Hammad, Villarreal, O. A. Martì, Mazza, G., Shakarami, Z., Sola, V., Staiano, A., Cirio, R., Sacchi, R., and Monaco, V.
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Physics - Medical Physics - Abstract
Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy could allow assessing the range of penetration during treatments, encouraging the development of new dose delivery techniques for moving targets. Towards this end, the proof of concept of a new device, able to measure in a few seconds the energy of clinical proton beams (from 60 to 230 MeV) from the Time of Flight (ToF) of protons, is presented. The prototype consists of two Ultra Fast Silicon Detector (UFSD) pads, featuring an active thickness of 80 um and a sensitive area of 3 x 3 mm2, aligned along the beam direction in a telescope configuration, connected to a broadband amplifier and readout by a digitizer. Measurements were performed at the Centro Nazionale di Adroterapia Oncologica (CNAO, Pavia, Italy), at five different clinical beam energies and four distances between the sensors (from 7 to 97 cm) for each energy. In order to derive the beam energy from the measured average ToF, several systematic effects were considered, Monte Carlo simulations were developed to validate the method and a global fit approach was adopted to calibrate the system. The results were benchmarked against the energy values obtained from the water equivalent depths provided by CNAO. Deviations of few hundreds of keV have been achieved for all considered proton beam energies for both 67 and 97 cm distances between the sensors and few seconds of irradiation were necessary to collect the required statistics. These preliminary results indicate that a telescope of UFSDs could achieve in a few seconds the accuracy required for the clinical application and therefore encourage further investigations towards the improvement and the optimization of the present prototype.
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- 2020
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35. Fired brick microparticles assisted oxidative radical polymerization of pyrrole for electrochemical sensing: Application to the determination of ciprofloxacin and metanil yellow in food products and environmental samples
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Alqarni, Ali O, Mahmoud, Ashraf M., Alyami, Bandar A., El-Wekil, Mohamed M., and Ali, Al-Montaser Bellah H.
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- 2023
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36. Modeling the effects of speed limit cameras (SLCs) on air quality and traffic flow on access-controlled highways
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Akin, Darcin, Raja, Arsalan A., AlAteah, Ali H., Almonbhi, Ali O., Sisiopiku, Virginia P., and Al-Sodani, Khaled A.A.
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- 2023
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37. Intrinsic self-calibration electrostatic-controlled ratiometric fluorescence assay of histamine in human serum and canned tuna fish samples
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Alyami, Bandar A., Mahmoud, Ashraf M., Alqarni, Ali O, and El-Wekil, Mohamed M.
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- 2023
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38. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, Adcock, K, Addai-Boampong, L, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, FW, Adesemoye, OA, Adewunmi, EO, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikari, B, Adhikari, SA, Adhikary, R, Aditya, A, Adjepong, P, Adkins, G, Adnan, A, Adriaanse, M, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Afrim, P, Afriyie, FA, Aftab, ZA, Afum-Adjei Awuah, A, Agarwal, M, Agasiya, PN, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Agyekum, JA, Agyen, K, Ahadome, EK, Ahamed Sadiq, S, Ahammed Nazeer, MH, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, BAR, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmed, M, Ahmed, MC, Ahmed, MS, Ahmed, N, Ahmed, O, Ahmed, RA, Ahmed, R, Ahmed, S, Ahmed, SG, Ahmed, SH, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aidoo, C, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, ASAR, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albertus, A, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Ale, RM, Alegria, A, Alexander, A, Alexander, C, Alexander, J, Alexander, PDG, Al-fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, FR, Ali, J, Ali, M, Ali, MS, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Alisjahbana, B, Aliyuda, F, Alizadeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsop, HK, Allsop, L, Allsup, D, Almahroos, AFT, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Amelia Ganefianty, A, Ames, K, Amezaga, MR, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amoah-Dankwa, J, Amoako-Adusei, A, Amosun, V, Amsal, M, Amsha, K, Amuasi, J, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, SD, Andari, NKN, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, WW, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Ansah, M, Anstey, PJ, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonina, Z, Anu, V, Anwar, M, Anwar, S, Apetri, E, Apostolopoulos, A, Appleby, S, Appleyard, D, Aquino, MF, Araba, B, Aransiola, S, Araujo, M, Archer, A, Archer, D, Archer, S, Arcoria, D, Ardley, C, Arhin-Sam, G, Arias, A-M, Aribike, O, Arimoto, R, Arisanti, NLPE, Arkley, C, Armah, C, Armata, I, Armistead, J, Armitage, A, Armstrong, C, Armstrong, M, Armstrong, S, Armstrong, W, Armtrong, P, Arndt, H, Arnison-Newgass, C, Arnold, D, Arnold, R, Arnott, A, Arora, D, Arora, K, Arora, P, Arora, R, Arter, A, Arthur, A, Artini, NM, Arumaithurai, A, Arya, A, Arya, R, Aryal, D, Asandei, D, Asare, GA, Asghar, A, Asghar, M, Ashab, A, Ashbrook-Raby, C, Ashby, H, Ashcroft, J, Ashcroft, S, Asher, G, Ashfak, Z, Ashfaq, A, Asiamah, HA, Ashish, A, Ashley, D, Ashman-Flavell, S, Ashok, S, Ashour, A-E-A, Ashraf, MZ, Ashraf, S, Ashraq, MB, Ashton, D, Ashton, S, Ashworth, A, Ashworth, FJ, Ashworth, R, Aslam, A, Aslam, I, Aslam, S, Aslett, L, Asogan, H, Asrar, A, Assaf, O, Astin-Chamberlain, R, Atabudzi, YE, Athavale, P, Athorne, D, Atkins, B, Atkins, C, Atkins, S, Atkinson, J, Atkinson, V, Atomode, A, Atraskiewicz, B, Attia, AA, Attubato, E, Attwood, M, Aubrey, P, Auer, Z, Aujayeb, A, Aung, AT, Aung, H, Aung, HWW, Aung, KK, Aung, KT, Aung, N, Aung, Y, Aung, ZM, Austin, E, Austin, K, Auwal, A, Avari, M, Avery, M, Aveyard, N, Avis, J, Aviss, G, Avram, C, Avram, P, Awadelkareem, A, Awadzi, G, Awaly, M, Awan, A, Awisi, S, Aya, A, Ayaz, E, Ayerh, JM, Ayers, A, Azam, J, Azeem, A, Azharuddin, M, Aziz, A, Aziz, G, Aziz, I, Aziz, N, Azkoul, A, Azman Shah, A, Azzopardi, G, Azzoug, H, Babatunde, F, Babi, M, Babiker, B, Babington, G, Babirecki, M, Babores, M, Babs-Osibodu, AO, Bac, T, Bacciarelli, S, Bachar, R, Bachour, M-E, Bachti, A, Bacon, G, Bacon, J, Badal, B, Badat, A, Bader, M, Badhan, GR, Badhrinarayanan, S, Bae, JP, Baggaley, A, Baggott, A, Bagley, G, Bagmane, D, Bagshaw, L, Bahadori, K, Bahurupi, Y, Bailey, A, Bailey, J, Bailey, K, Bailey, L, Bailey, MA, Bailey, M, Bailey, P, Bailey, S, Baillie, H, Baillie, JK, Bain, J, Bains, V, Baird, D, Baird, E, Baird, K, Baird, S, Baird, T, Baird, Y, Bajandouh, A, Baker, DC, Baker, E, Baker, J, Baker, K, Baker, M, Baker, R, Baker, T-A, Baker, V, Bakere, H, Bakerly, N, Baker-Moffatt, M, Bakhai, A, Bakhtiar, N, Bakoulas, P, Bakthavatsalam, D, Balachandran, N, Balan, A, Balasingam, P, Balaskas, T, Balasubramaniam, M, Balatoni, N, Balcombe, A, Baldwin, A, Baldwin, C, Baldwin, D, Baldwin, F, Baldwin-Jones, R, Bale, N, Balfour, J, Ball, M, Ball, Ro, Ballard, K, Balluz, I, Balmforth, C, Balogh, E, Baltmr, A, Baluwala, A, Bambridge, G, Bamford, A, Bamford, P, Bamgboye, A, Bancroft, E, Bancroft, H, Banda, J, Bandaru, K, Bandi, S, Bandla, N, Bandyopadhyam, S, Banerjee, A, Banerjee, R, Bang, P, Baniya, S, Bani-Saad, O, Banks, H, Banks, L, Banks, P, Bann, C, Bannister, H, Bannister, O, Banton, L, Bao, T, Baptist, M, Baqai, T, Baral, AM, Baral, SC, Baramova, D, Barber, R, Barbon, E, Barbosa, M, Barbour, J, Barclay, A, Barclay, C, Bardsley, G, Bareford, S, Bari, S, Barimbing, M, Barker, A, Barker, D, Barker, E, Barker, H, Barker, J, Barker, L, Barker, O, Barker-Williams, K, Barkha, S, Barla, J, Barlow, G, Barlow, R, Barlow, V, Barnacle, J, Barnard, A, Barnes, D, Barnes, N, Barnes, R, Barnes, T, Barnetson, C, Barnett, A, Barnett-Vanes, A, Barning, PG, Barnsley, W, Barr, A, Barr, D, Barr, J, Barr, C, Barratt, N, Barratt, S, Barrera, M, Barrett, A, Barrett, Fi, Barrett, J, Barrett, S, Barrow, E, Bartholomew, J, Barthwal, MS, Bartlett, C, Bartlett, G, Bartlett, J, Bartlett, L, Bartley, S, Bartolmeu-Pires, S, Barton, A, Barton, G, Barton, J, Barton, L, Barton, R, Baruah, R, Baryschpolec, S, Bashir, H, Bashyal, A, Basker, B, Basnet, S, Basnyat, B, Basoglu, A, Basran, A, Bassett, J, Bassett, G, Bassford, C, Bassoy, B, Bastion, V, Bastola, A, Basumatary, A, Basvi, P, Batac, JA, Bataduwaarachchi, VR, Bate, T, Bateman, HJ, Bateman, K, Bateman, V, Bates, E, Bates, H, Bates, M, Bates, S, Batham, S, Batista, A, Batla, A, Batra, D, Batty, H, Batty, T, Batty, A, Baum, M, Baumber, R, Bautista, C, Bawa, F, 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Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, A, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittaker, E, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, S, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, CV, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, P, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, C, Williamson, D, Williamson, J, Williamson, JD, Williamson, R, Williamson, H, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Willson, F, Willson, J, Wilson, A, Wilson, B, Wilson, D, Wilson, I, Wilson, J, Wilson, K, Wilson, K-A, Wilson, L, Wilson, M, Wilson, S, Wilson, T, Win, KLY, Win, M, Win, T, Win, TT, Win, WYW, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, WIshlade, T, Witele, E, Withers, N, Wittes, J, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C-H, Wong, C-M, Wong, E, Wong, JSY, Wong, KY, Wong, MY, Wong, N, Wong, S, Wong, T, Wongkyezeng, AA, Wood, A, Wood, C, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, F, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, BE, Xia, Z, Yacoba, E, Yadav, S, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, WL, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, T, Yates, M, Ye, J, Yearwood Martin, C, Yein, K, Yelnoorkar, F, Yen, LM, Yeoh, A, Yeung, CY, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yovita, H, Yu, C, Yuan, JSJ, Yufaniaputri, N, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-S, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zayed, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zhu, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, ET, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2023
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39. Association Between Cardiovascular Event Type and Smoking Cessation Rates Among Outpatients With Atherosclerotic Cardiovascular Disease: Insights From the NCDR PINNACLE Registry
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Hejjaji, Vittal, Ellerbeck, Edward F., Jones, Philip G., Pacheco, Christina M., Malik, Ali O., Chan, Paul S., Spertus, John A., and Arnold, Suzanne V.
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- 2024
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40. Variation in palmaromedial articulations of carpometacarpal joints in Thoroughbred and Standardbred racehorses
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Aiman H. Oheida, Aiman A. Shalgum, Abdulrhman M. Alrtib, Ali O. Booker, Khaled M. Ben-Naser, and Helen M.S. Davies
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carpometacarpal joint ,radiology ,standardbreds ,thoroughbreds ,variation ,Zoology ,QL1-991 - Abstract
Background: Carpal conformation is an important factor in relation to the joint soundness. The equine carpometacarpal joint was reported to have variations in its three palmaromedial articulations. Lacking one or more of these articulations has not been radiographically evaluated in Thoroughbred (TB) and Standardbred (SB) racehorses. Aim: The study aimed to identify the prevalence of the variation in the palmaromedial articulation of the carpometacarpal joint (PM-CMCJ) in TB and SB horses. Additionally, to detect the probability of having each of the three articulations within and between the breeds. Finally, to establish an anatomical description for the different patterns of the articulations in these horses. Methods: 313 dorsopalmar radiographs from 174 horses (117 TB and 57 SB) were used. Three articulations at PM-CMCJ were evaluated based on their presence or absence: the articulations between the second and third carpal bones (C2-C3), the second carpal-second metacarpal (C2-Mc2) and the second and third metacarpal (Mc2-Mc3) bones. Probability of each articulation was determined in the breeds. Depending on the presence/absence of one or more of these articulations in each horse, each group of horses that had the same patterns of the articulation was gathered into one category. Results: Prevalence of variation in articulations of PM-CMCJ was identified in about 28% of the horses. SB showed a higher variation than TB throughout the comparisons. C2-C3 articulation was significantly the most common articulation, especially in TB (98%). The most common pattern of articulations (73%) was found in Category I, which had the three articulations whereas 3 horses that grouped in Category VI had no palmaromedial articulations. Conclusion: The variations in the articulations of PM-CMCJ in TB and SB racehorse might show a breed association. C2-C3 articulation was considerably the most frequent feature and Category I was the common pattern of articulations in PM-CMCJ. Potential clinical effects of the varied patterns of the articulations require investigation. [Open Vet J 2023; 13(5.000): 569-575]
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- 2023
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41. Oral contraceptive pills shortage in Lebanon amidst the economic collapse: a nationwide exploratory study
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Rania Itani, Hani MJ Khojah, Samar Karout, Rana Abu-Farha, Tareq L. Mukattash, Deema Rahme, Khouloud Housary, Hiam El Achi, Ali O. Safar, Ismail Karam Al Hajj, and Abdalla El-Lakany
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Oral contraceptive pills ,Contraception ,Economic crisis ,Women ,Reproductive health ,Abortion ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The political instability, economic crisis, and devaluation of the national currency left Lebanese females suffering from a scarcity of oral contraceptive pills (OCPs). Therefore, we aimed to identify the incidence of OCPs shortage in Lebanon and its impact on women’s sexual and reproductive health, as well as physical and psychological well-being. Methods Community pharmacies were selected randomly across Lebanon, using a stratified sampling approach, where female clients asking for OCPs were interviewed using a standardized data collection form. Results A total of 440 females were interviewed. More than three-quarters of the participants (76.4%) reported not finding their preferred OCPs brands, almost 40% were affected by the increased prices, and 28.4% declared stockpiling OCPs. More than half of the participants using OCPs for pregnancy prevention reported adopting alternative traditional contraceptive methods (55.3%). Unplanned pregnancy was reported by 9.5% of participants, where 75% of them disclosed intentional abortion while the remaining (25%) reported experiencing a spontaneous miscarriage. Other consequences of OCPs shortage included mood disturbances (52.3%), dysregulation of menses (49.7%), dysmenorrhea (21.1%), weight gain (19.6%), acne (15.7%), and hirsutism (12.5%). Of the participants taking OCPs for birth control, 48.6% reported a reduced frequency of sexual intercourse, which led to conflicts with their partners (46%) and a decreased libido (26.7%). Conclusions OCPs shortage has seriously and negatively exposed women to various undesirable consequences including unplanned pregnancy and dysregulation of menses. Therefore, there is an urgent need to bring the attention of healthcare authorities to support the national pharmaceutical industry in manufacturing affordable OCPs generics to meet women’s reproductive health demands.
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- 2023
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42. Coordinated molecularly imprinted-based ratiometric sensor for electrochemical sensing of hazardous ciprofloxacin based on nitrogen and sulfur co-doped porous carbon/silver nanoparticles hybrid
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Mahmoud, Ashraf M., Abu-Alrub, Samer S., Al-Qarni, Ali O., Alshareef, F.M., and El-Wekil, Mohamed M.
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- 2023
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43. Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations JACC State-of-the-Art Review
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Newman, Jonathan D, Bhatt, Deepak L, Rajagopalan, Sanjay, Balmes, John R, Brauer, Michael, Breysse, Patrick N, Brown, Alison GM, Carnethon, Mercedes R, Cascio, Wayne E, Collman, Gwen W, Fine, Lawrence J, Hansel, Nadia N, Hernandez, Adrian, Hochman, Judith S, Jerrett, Michael, Joubert, Bonnie R, Kaufman, Joel D, Malik, Ali O, Mensah, George A, Newby, David E, Peel, Jennifer L, Siegel, Jeffrey, Siscovick, David, Thompson, Betsy L, Zhang, Junfeng, and Brook, Robert D
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Climate-Related Exposures and Conditions ,Clinical Research ,Clinical Trials and Supportive Activities ,Prevention ,Aetiology ,2.2 Factors relating to the physical environment ,Generic health relevance ,Good Health and Well Being ,Air Pollution ,Clinical Trials as Topic ,Education ,Heart Diseases ,Humans ,Lung Diseases ,Particulate Matter ,cardiopulmonary disease ,cardiovascular disease ,fine particulate air pollution ,portable air cleaner ,randomized clinical trials ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
Fine particulate air pollution
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- 2020
44. Understanding the Influence of the Buoyancy Sign on Buoyancy-Driven Particle Clouds
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Ali O. Alnahit, Nigel Berkeley Kaye, and Abdul A. Khan
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particle clouds ,dredging ,two-phase flows ,integral models ,Thermodynamics ,QC310.15-319 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
A numerical model was developed to investigate the behavior of round buoyancy-driven particle clouds in a quiescent ambient. The model was validated by comparing model simulations with prior experimental and numerical results and then applied the model to examine the difference between releases of positively and negatively buoyant particles. The particle cloud model used the entrainment assumption while approximating the flow field induced by the cloud as a Hill’s spherical vortex. The motion of individual particles was resolved using a particle tracking equation that considered the forces acting on them and the induced velocity field. The simulation results showed that clouds with the same initial buoyancy magnitude and particle Reynolds number behaved differently depending on whether the particles were more dense or less dense than the ambient fluid. This was found even for very low initial buoyancy releases, suggesting that the sign of the buoyancy is always important and that, therefore, the Boussinesq assumption is never fully appropriate for such flows.
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- 2024
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45. Green Synthesis of Gold Nanoparticles Using Liquiritin and Other Phenolics from Glycyrrhiza glabra and Their Anti-Inflammatory Activity
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Ali O. E. Eltahir, Kim L. Lategan, Oladipupo M. David, Edmund J. Pool, Robert C. Luckay, and Ahmed A. Hussein
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Glycyrrhiza glabra ,licorice ,liquiritin ,phenolic compounds ,gold nanoparticles ,lipopolysaccharide ,Biotechnology ,TP248.13-248.65 ,Medicine (General) ,R5-920 - Abstract
Phenolic compounds are the main phytochemical constituents of many higher plants. They play an important role in synthesizing metal nanoparticles using green technology due to their ability to reduce metal salts and stabilize them through physical interaction/conjugation to the metal surface. Six pure phenolic compounds were isolated from licorice (Glycyrrhiza glabra) and employed in synthesizing gold nanoparticles (AuNPs). The isolated compounds were identified as liquiritin (1), isoliquiritin (2), neoisoliquiritin (3), isoliquiritin apioside (4), liquiritin apioside (5), and glabridin (6). The synthesized AuNPs were characterized using UV, zeta sizer, HRTEM, and IR and tested for their stability in different biological media. The phenolic isolates and their corresponding synthesized NP conjugates were tested for their potential in vitro cytotoxicity. The anti-inflammatory effects were investigated in both normal and inflammation-induced settings, where inflammatory biomarkers were stimulated using lipopolysaccharides (LPSs) in the RAW 264.7 macrophage cell line. LPS, functioning as a mitogen, promotes cell growth by reducing apoptosis, potentially contributing to observed outcomes. Results indicated that all six pure phenolic isolates inhibited cell proliferation. The AuNP conjugates of all the phenolic isolates, except liquiritin apioside (5), inhibited cell viability. LPS initiates inflammatory markers by binding to cell receptors and setting off a cascade of events leading to inflammation. All the pure phenolic isolates, except isoliquiritin, neoisoliquiritin, and isoliquiritin apioside inhibited the inflammatory activity of RAW cells in vitro.
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- 2024
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46. Systemic Immune-Inflammation Index in Relation to Diabetes Markers in Saudi Adults: A Retrospective Study
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Ghadeer S. Aljuraiban, Fahad J. Alharbi, Ali O. Aljohi, Abdullah Z. Almeshari, Masoud N. Alotaibi, Salem S. AlShammari, Sara Al-Musharaf, Madhawi M. Aldhwayan, and Manal Abudawood
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inflammatory markers ,systemic immune-inflammation index ,diabetes ,diabetes markers ,fasting blood glucose ,HbA1c ,Medicine (General) ,R5-920 - Abstract
Background and objectives: Low-grade inflammation is associated with metabolic disturbances like diabetes. The systemic immune-inflammation index (SII) has been proposed as a predictive tool to identify individuals at a greater risk of diabetes. This study aims to examine the association between SII and diabetes markers. Method and materials: We used retrospective data from a large cohort of adults (n = 3895) aged ≥18 in Saudi Arabia. The SII was calculated, and the markers of diabetes such as fasting blood glucose (FBG), insulin, and hemoglobin A1c (HbA1c) were included. Results: Across the quartiles of SII, FBG, insulin, and HbA1c were significantly higher in adults with higher compared to lower SII (p < 0.0001, p = 0.04, p < 0.0001, respectively). A two SD higher FBG was significantly associated with an SII difference of 47.7 (95% CI: (15.5, 91.9)). In subgroup analysis, this relationship prevailed in normal-weight participants and among those with normoglycemia and prediabetes but was attenuated in participants with diabetes. The association also prevailed in separate analyses for males and females but was stronger among females. Linear regression models showed no significant association between insulin, HbA1c, and SII. Conclusions: SII was associated with the markers of diabetes. The utility of SII for predicting diabetes can be confirmed with prospective cohort studies.
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- 2024
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47. An Efficient Beam and Channel Acquisition via Sparsity Map and Joint Angle-Delay Power Profile Estimation for Wideband Massive MIMO Systems
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Kalayci, Ali O. and Guvensen, Gokhan M.
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Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
In this paper, an efficient beam and channel acquisition scheme together with joint angle-delay power profile (JADPP) construction are proposed for single-carrier mm-wave wideband sparse massive multiple-input multiple-output (MIMO) channels when hybrid beamforming architecture is utilized. We consider two different modes of operation, namely slow-time beam acquisition and fast-time instantaneous channel estimation, for training stage of time division duplex based systems. In the first mode, where pre-structured hybrid beams are formed to scan intended angular sectors, the joint angle-delay sparsity map together with power intensities of each user channels are obtained by using a novel constant false alarm rate thresholding algorithm inspired from adaptive radar detection theory. The proposed thresholding algorithm employs a spatio-temporal adaptive matched filter type estimator, taking the strong interference due to simultaneously active multipath components of different user channels into account, in order to estimate JADPP of each user. After applying the proposed thresholding algorithm on the estimated power profile, the angle-delay sparsity map of the massive MIMO channel is constructed, based on which the channel covariance matrices (CCMs) are formed with significantly reduced amount of training snapshots. Then, by using the estimated CCMs, the analog beamformer is reconstructed by means of a virtual sectorization while taking the inter-group and inter-symbol interference into account. Finally, for the second mode of operation, two novel reduced-rank instantaneous channel estimators, operating in a proper beamspace formed by the hybrid structure, are proposed. The proposed beam and channel acquisition techniques attain the channel estimation accuracy of minimum mean square error filter with true knowledge of CCMs., Comment: 32 pages, 14 figures
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- 2019
48. Convenient electrochemical and fluorometric dual-mode estimation of diosmin using carbon dots doped with nitrogen derived from chicken feet biowaste
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Mahmoud, Ashraf M., Abu-Alrub, Samer S., Alqarni, Ali O., El-Wekil, Mohamed M., and Ali, Al-Montaser Bellah H.
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- 2023
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49. Hospital-Level Variability in Use of Intracoronary Imaging for Percutaneous Coronary Intervention in the United States
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Malik, Ali O., Saxon, John T., Spertus, John A., Salisbury, Adam, Grantham, James A., Kennedy, Kevin, and Huded, Chetan P.
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- 2023
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50. NOTCH3 variants in patients with suspected CADASIL
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Orhan Gorukmez, Ozlem Gorukmez, Ali Topak, Meral Seferoglu, Ali O Sivaci, Asuman Ali, Nermin Tepe, Sibel C Kabay, and Ozlem Taskapilioglu
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cadasil ,ngs ,notch3 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) is the most common hereditary form of cerebral small vessel disease. It is clinically, radiologically, and genetically heterogeneous and is caused by NOTCH3 mutations. Methods: In this study, we analyzed NOTCH3 in 368 patients with suspected CADASIL using next-generation sequencing. The significant variants detected were reported along with the clinical and radiological features of the patients. Results: Heterozygous NOTCH3 changes, mostly missense mutations, were detected in 44 of the 368 patients (~12%). Conclusions: In this single-center study conducted on a large patient group, 30 different variants were detected, 17 of which were novel. CADASIL, which can result in mortality, has a heterogeneous phenotype among individuals in terms of clinical, demographic, and radiological findings regardless of the NOTCH3 variant.
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- 2023
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