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Your search keyword '"Ali, Howaida S."' showing total 9 results
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9 results on '"Ali, Howaida S."'

4. Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Author

Salem, Hoda A., primary, Abu-Elfotuh, Karema, additional, Alzahrani, Sharifa, additional, Rizk, Nermin I., additional, Ali, Howaida S., additional, Elsherbiny, Nehal, additional, Aljohani, Alhanouf, additional, Hamdan, Ahmed M. E., additional, Chellasamy, Panneerselvam, additional, Abdou, Nada S., additional, Gowifel, Ayah M. H., additional, Darwish, Alshaymaa, additional, Ibrahim, Osama Mohamed, additional, and Abd Elmageed, Zakaria Y., additional

Published
2023
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6. Chemotherapeutic potential of betanin/capecitabine combination targeting colon cancer: experimental and bioinformatic studies exploring NFκB and cyclin D1 interplay.

Author

Ahmed, Rehab, Zaitone, Sawsan A., Abdelmaogood, Asmaa K. K., Atef, Huda M., Soliman, Mona F. M., Badawy, Alaa M., Ali, Howaida S., Zaid, AbdelNaser, Mokhtar, Hatem I., Elabbasy, Lamiaa M., Kandil, Emad, Yosef, Asmaa Mokhtar, and Mahran, Rama I.

Subjects
COLON cancer, CHEMICAL carcinogenesis, CYCLINS, BIOLOGICAL assay, CANCER chemotherapy
Abstract

Introduction: Betanin (C24H26N2O13) is safe to use as food additives approved by the FDA with anti-inflammatory and anticancer effects in many types of cancer cell lines. The current experiment was designed to test the chemotherapeutic effect of the combination of betanin with the standard chemotherapeutic agent, capecitabine, against chemically induced colon cancer in mice. Methods: Bioinformatic approachwas designed to get information about the possible mechanisms through which the drugs may control cancer development. Five groups of mice were assigned as, (i) saline, (ii) colon cancer, (iii) betanin, (iv) capecitabine and (v) betanin/capecitabine. Drugs were given orally for a period of six weeks. Colon tissues were separated and used for biological assays and histopathology. Results: In addition, the mRNA expression of TNF-a (4.58-fold), NFκB (5.33-fold), IL-1β (4.99-fold), cyclin D1 (4.07-fold), and IL-6 (3.55-fold) and protein levels showed several folds increases versus the saline group. Tumor histopathology scores in the colon cancer group (including cryptic distortion and hyperplasia) staining demonstrated poor mucin content (33% of the saline group). These pathologic manifestations were reduced remarkably in betanin/capecitabine group. Conclusion: Collectively, our findings demonstrated the usefulness of betanin/capecitabine combination in targeting colon cancer and highlighted that betanin is a promising adjuvant therapy to capecitabine in treating colon cancer patients. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production

Author

Attia, Mohammed A., primary, Soliman, Nema, additional, Eladl, Mohamed Ahmed, additional, Bilasy, Shymaa E., additional, El-Abaseri, Taghrid B., additional, Ali, Howaida S., additional, Abbas, Faten, additional, Ibrahim, Dalia, additional, Osman, Noura M. S., additional, Hashish, Abdullah A., additional, Alshahrani, Asma, additional, Mohamed, Abir S., additional, and Zaitone, Sawsan A., additional

Published
2023
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8. Leflunomide Induces Dose-Dependent Lung Injury in Mice via Stimulating Vimentin and NLRP3 Inflammasome Production

Author

El-Sherbiny, Mohamed, primary, Atef, Hoda, additional, Eladl, Mohamed Ahmed, additional, Mohamed, Abdelaty Shawky, additional, El-Shafey, Mohamed, additional, Ali, Howaida S., additional, Zaitone, Sawsan A., additional, Alomar, Suliman Y., additional, Alqahtani, Saeed Awad M., additional, Aloyouni, Sheka Yagub, additional, and Attia, Mohammed A., additional

Published
2021
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