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346 results on '"Algeri, Mattia"'

1. Outcomes of HLA-mismatched HSCT with TCRαβ/CD19 depletion or post-HSCT cyclophosphamide for inborn errors of immunity

Author

Lum, Su Han, Albert, Michael H., Gilbert, Patrick, Sirait, Tiarlan, Algeri, Mattia, Muratori, Rafaella, Fournier, Benjamin, Laberko, Alexandra, Karakukcu, Musa, Unal, Elrem, Ayas, Mouhab, Yadav, Satya Prakash, Fisgin, Tunc, Elfeky, Reem, Fernandes, Juliana, Faraci, Maura, Cole, Theresa, Schulz, Ansgar, Meisel, Roland, Zecca, Marco, Ifversen, Marianne, Biffi, Alessandra, Diana, Jean-Sebastien, Vallée, Tanja, Giardino, Stefano, Ersoy, Gizem Zengin, Moshous, Despina, Gennery, Andrew R., Balashov, Dmitry, Bonfim, Carmem, Locatelli, Franco, Lankester, Arjan, Neven, Bénédicte, and Slatter, Mary

Published
2024
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3. TCRαβ/CD19 cell–depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis

Author

Merli, Pietro, Algeri, Mattia, Galaverna, Federica, Bertaina, Valentina, Lucarelli, Barbarella, Boccieri, Emilia, Becilli, Marco, Quagliarella, Francesco, Rosignoli, Chiara, Biagini, Simone, Girolami, Elia, Meschini, Antonella, Del Principe, Giovanna, Sborgia, Raffaella, Catanoso, Maria Luigia, Carta, Roberto, Strocchio, Luisa, Pinto, Rita Maria, Buldini, Barbara, Falco, Michela, Meazza, Raffaella, Pende, Daniela, Andreani, Marco, Li Pira, Giuseppina, Pagliara, Daria, and Locatelli, Franco

Published
2024
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4. Allogeneic, donor-derived, second-generation, CD19-directed CAR-T cells for the treatment of pediatric relapsed/refractory BCP-ALL

Author

del Bufalo, Francesca, Becilli, Marco, Rosignoli, Chiara, De Angelis, Biagio, Algeri, Mattia, Hanssens, Linda, Gunetti, Monica, Iacovelli, Stefano, Li Pira, Giuseppina, Girolami, Elia, Leone, Giovanna, Lazzaro, Stefania, Bertaina, Valentina, Sinibaldi, Matilde, Di Cecca, Stefano, Iaffaldano, Laura, Künkele, Annette, Boccieri, Emilia, Del Baldo, Giada, Pagliara, Daria, Merli, Pietro, Carta, Roberto, Quintarelli, Concetta, and Locatelli, Franco

Published
2023
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6. Tisagenlecleucel therapy for relapsed or refractory B-cell acute lymphoblastic leukaemia in infants and children younger than 3 years of age at screening: an international, multicentre, retrospective cohort study

Author

Ghorashian, Sara, Jacoby, Elad, De Moerloose, Barbara, Rives, Susana, Bonney, Denise, Shenton, Geoff, Bader, Peter, Bodmer, Nicole, Quintana, Agueda Molinos, Herrero, Blanca, Algeri, Mattia, Locatelli, Franco, Vettenranta, Kim, Gonzalez, Berta, Attarbaschi, Andishe, Harris, Stephen, Bourquin, Jean Pierre, and Baruchel, André

Published
2022
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7. Busulfan–fludarabine- or treosulfan–fludarabine-based myeloablative conditioning for children with thalassemia major

Author

Lüftinger, Roswitha, Zubarovskaya, Natalia, Galimard, Jacques-Emmanuel, Cseh, Annamaria, Salzer, Elisabeth, Locatelli, Franco, Algeri, Mattia, Yesilipek, Akif, de la Fuente, Josu, Isgrò, Antonella, Alseraihy, Amal, Angelucci, Emanuele, Smiers, Frans J., La La Nasa, Giorgia, Zecca, Marco, Fisgin, Tunc, Unal, Emel, Kleinschmidt, Katharina, Peters, Christina, Lankester, Arjan, and Corbacioglu, Selim

Published
2022
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9. Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

Author

Caruso, Simona, De Angelis, Biagio, Del Bufalo, Francesca, Ciccone, Roselia, Donsante, Samantha, Volpe, Gabriele, Manni, Simona, Guercio, Marika, Pezzella, Michele, Iaffaldano, Laura, Silvestris, Domenico Alessandro, Sinibaldi, Matilde, Di Cecca, Stefano, Pitisci, Angela, Velardi, Enrico, Merli, Pietro, Algeri, Mattia, Lodi, Mariachiara, Paganelli, Valeria, Serafini, Marta, Riminucci, Mara, Locatelli, Franco, and Quintarelli, Concetta

Published
2022
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10. Variables affecting outcomes after allogeneic hematopoietic stem cell transplant for cerebral adrenoleukodystrophy

Author

Chiesa, Robert, Boelens, Jaap Jan, Duncan, Christine N., Kühl, Jörn-Sven, Sevin, Caroline, Kapoor, Neena, Prasad, Vinod K., Lindemans, Caroline A., Jones, Simon A., Amartino, Hernan M., Algeri, Mattia, Bunin, Nancy, Diaz-de-Heredia, Cristina, Loes, Daniel J., Shamir, Esther, Timm, Alison, McNeil, Elizabeth, Dietz, Andrew C., and Orchard, Paul J.

Published
2022
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11. Autologous CD19‐Targeting CAR T Cells in a Patient With Refractory Juvenile Dermatomyositis.

Author

Nicolai, Rebecca, Merli, Pietro, Moran Alvarez, Patricia, Bracaglia, Claudia, Del Bufalo, Francesca, Marasco, Emiliano, Caiello, Ivan, Prencipe, Giusi, Algeri, Mattia, Cefalo, Maria G., Becilli, Marco, Quintarelli, Concetta, Sinibaldi, Matilde, Hanssens, Linda, De Benedetti, Fabrizio, and Locatelli, Franco

Subjects
DERMATOMYOSITIS, IMMUNIZATION, T cells, PATIENT safety, RESEARCH funding, RITUXIMAB, MAGNETIC resonance imaging, ANTIGENS, DRUG efficacy, LEUKAPHERESIS, CYCLOPHOSPHAMIDE, CHILDREN
Abstract

Objective: The aim of this study is to report the safety and efficacy of CD19‐targeting chimeric antigen receptor (CAR) T cells in a child with refractory juvenile dermatomyositis (JDM). Methods: We describe a 12‐year‐old White male with severe, chronically active JDM refractory to multiple immunosuppressive treatment lines, including B cell depletion with rituximab. The patient received a single infusion of fresh, autologous, second‐generation anti‐CD19 CAR T cell product (lentiviral vector) manufactured on the Prodigy device (1 × 106 CAR T cells/kg), after lymphodepletion with cyclophosphamide (1,000 mg/m2 over two days) and fludarabine (90 mg/m2 over three days). Immunosuppressive and glucocorticoid treatment were withdrawn before leukapheresis and CAR T cell infusion. Results: Before anti‐CD19 CAR T cell therapy, the patient had persistent severe skin and muscular disease activity. CAR T cells expanded significantly (peak at day 7, 32.69 cells/μL). Complete B cell depletion was documented on day 5 in the blood and at week 2 in the bone marrow. The patient presented with fever as part of mild cytokine release syndrome (grade 1), transient anemia (grade 2), and neutropenia (grade 4). Neither infection nor neurotoxicity were observed. Laboratory tests, magnetic resonance imaging, Physician Global Assessment of disease activity, Childhood Myositis Assessment Scale, and Cutaneous Assessment Tool for myositis were performed at baseline and follow‐up to assess treatment response, showing remarkable progressive improvement that persists over time, even after B cell recovery. Conclusion: This patient with JDM with severe chronic disease, refractory to multiple treatments, achieved sustained B cell depletion and ongoing immunosuppressive drug‐free clinical and radiologic improvement eight months after a single infusion of anti‐CD19 CAR T cells. [ABSTRACT FROM AUTHOR]

Published
2024
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12. TCRαβ/CD19 depleted HSCT from an HLA-haploidentical relative to treat children with different nonmalignant disorders

Author

Merli, Pietro, Pagliara, Daria, Galaverna, Federica, Li Pira, Giuseppina, Andreani, Marco, Leone, Giovanna, Amodio, Donato, Pinto, Rita Maria, Bertaina, Alice, Bertaina, Valentina, Mastronuzzi, Angela, Strocchio, Luisa, Boccieri, Emilia, Pende, Daniela, Falco, Michela, Di Nardo, Matteo, Del Bufalo, Francesca, Algeri, Mattia, and Locatelli, Franco

Published
2022
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13. Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Author

Locatelli, Franco, primary, Lang, Peter, additional, Wall, Donna, additional, Meisel, Roland, additional, Corbacioglu, Selim, additional, Li, Amanda M., additional, de la Fuente, Josu, additional, Shah, Ami J., additional, Carpenter, Ben, additional, Kwiatkowski, Janet L., additional, Mapara, Markus, additional, Liem, Robert I., additional, Cappellini, Maria Domenica, additional, Algeri, Mattia, additional, Kattamis, Antonis, additional, Sheth, Sujit, additional, Grupp, Stephan, additional, Handgretinger, Rupert, additional, Kohli, Puja, additional, Shi, Daoyuan, additional, Ross, Leorah, additional, Bobruff, Yael, additional, Simard, Christopher, additional, Zhang, Lanju, additional, Morrow, Phuong Khanh, additional, Hobbs, William E., additional, and Frangoul, Haydar, additional

Published
2024
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14. HLA‐haploidentical stem cell transplantation in children with inherited bone marrow failure syndromes: A retrospective analysis on behalf of EBMT severe aplastic Anemia and pediatric diseases working parties

Author

Giardino, Stefano, primary, Eikema, Dirk‐Jan, additional, Piepenbroek, Brian, additional, Algeri, Mattia, additional, Ayas, Mouhab, additional, Faraci, Maura, additional, Tbakhi, Abdelghani, additional, Zecca, Marco, additional, Essa, Mohammed, additional, Neven, Bénédicte, additional, Bertrand, Yves, additional, Kharya, Gaurav, additional, Bykova, Tatiana, additional, Lawson, Sarah, additional, Petrini, Mario, additional, Mohseny, Alexander, additional, Rialland, Fanny, additional, James, Beki, additional, Colita, Anca, additional, Fahd, Mony, additional, Cesaro, Simone, additional, Schulz, Ansgar, additional, Kleinschmidt, Katharina, additional, Kałwak, Krzysztof, additional, Corbacioglu, Selim, additional, Dufour, Carlo, additional, Risitano, Antonio, additional, and de Latour, Régis Peffault, additional

Published
2024
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17. Dissecting the mechanisms of bone loss in Gorham-Stout disease

Author

Rossi, Michela, Buonuomo, Paola Sabrina, Battafarano, Giulia, Conforti, Antonella, Mariani, Eda, Algeri, Mattia, Pelle, Simone, D’Agostini, Matteo, Macchiaiolo, Marina, De Vito, Rita, Gonfiantini, Michaela Veronika, Jenkner, Alessandro, Rana, Ippolita, Bartuli, Andrea, and Del Fattore, Andrea

Published
2020
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18. Matched unrelated donor transplantation versus haploidentical transplantation with post-transplant cyclophosphamide in children with acute myeloid leukemia: a PDWP-EBMT study

Author

Ruggeri, Annalisa, primary, Santoro, Nicole, additional, Galimard, Jacques-Emmanuel, additional, Kalwak, Krzysztof, additional, Algeri, Mattia, additional, Zubarovskaya, Ludmila, additional, Czyzewski, Krzysztof, additional, Skorobogatova, Elena, additional, Sedlacek, Petr, additional, Besley, Caroline, additional, Balduzzi, Adriana, additional, Bertrand, Yves, additional, Peristeri, Julia, additional, Fagioli, Franca, additional, Ifversen, Mariane, additional, Gozdzik, Jolanta, additional, Peters, Christina, additional, Versluijs, Birgitta, additional, Biffi, Alessandra, additional, Prete, Arcangelo, additional, Faraci, Maura, additional, Ghemlas, Ibrahim, additional, Bodova, Ivana, additional, Aleinikova, Olga, additional, Dalissier, Arnaud, additional, Rocha, Vanderson, additional, and Corbacioglu, Selim, additional

Published
2024
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20. Unrelated donor vs HLA-haploidentical α/β T-cell– and B-cell–depleted HSCT in children with acute leukemia

Author

Bertaina, Alice, Zecca, Marco, Buldini, Barbara, Sacchi, Nicoletta, Algeri, Mattia, Saglio, Francesco, Perotti, Cesare, Gallina, Anna Maria, Bertaina, Valentina, Lanino, Edoardo, Prete, Arcangelo, Barberi, Walter, Tumino, Manuela, Favre, Claudio, Cesaro, Simone, Del Bufalo, Francesca, Ripaldi, Mimmo, Boghen, Stella, Casazza, Gabriella, Rabusin, Marco, Balduzzi, Adriana, Fagioli, Franca, Pagliara, Daria, and Locatelli, Franco

Published
2018
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23. A phase I study of autologous mesenchymal stromal cells for severe steroid-dependent nephrotic syndrome

Author

Vivarelli, Marina, primary, Colucci, Manuela, additional, Algeri, Mattia, additional, Zotta, Federica, additional, Emma, Francesco, additional, L’Erario, Ines, additional, Busutti, Marco, additional, Rota, Stefano, additional, Capelli, Chiara, additional, Introna, Martino, additional, Todeschini, Marta, additional, Casiraghi, Federica, additional, Perna, Annalisa, additional, Peracchi, Tobia, additional, De Salvo, Andrea, additional, Rubis, Nadia, additional, Locatelli, Franco, additional, Remuzzi, Giuseppe, additional, and Ruggenenti, Piero, additional

Published
2023
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24. Outcomes of Children with Hemophagocytic Lymphohistiocytosis Given Allogeneic Hematopoietic Stem Cell Transplantation in Italy

Author

Messina, Chiara, Zecca, Marco, Fagioli, Franca, Rovelli, Attilio, Giardino, Stefano, Merli, Pietro, Porta, Fulvio, Aricò, Maurizio, Sieni, Elena, Basso, Giuseppe, Ripaldi, Mimmo, Favre, Claudio, Pillon, Marta, Marzollo, Antonio, Rabusin, Marco, Cesaro, Simone, Algeri, Mattia, Caniglia, Maurizio, Di Bartolomeo, Paolo, Ziino, Ottavio, Saglio, Francesco, Prete, Arcangelo, and Locatelli, Franco

Published
2018
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27. Impact of Treosulfan Exposure on Early and Long-Term Clinical Outcomes in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients: A Prospective Multicenter Study

Author

van der Stoep, M.Y. Eileen C., Bertaina, Alice, Moes, Dirk Jan A.R., Algeri, Mattia, Bredius, Robbert G.M., Smiers, Frans J.W., Berghuis, Dagmar, Buddingh, Emilie P., Mohseny, Alexander B., Guchelaar, Henk-Jan, Locatelli, Franco, Zwaveling, Juliette, and Lankester, Arjan C.

Published
2022
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28. Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

Author

Locatelli, Franco, Merli, Pietro, Pagliara, Daria, Li Pira, Giuseppina, Falco, Michela, Pende, Daniela, Rondelli, Roberto, Lucarelli, Barbarella, Brescia, Letizia Pomponia, Masetti, Riccardo, Milano, Giuseppe Maria, Bertaina, Valentina, Algeri, Mattia, Pinto, Rita Maria, Strocchio, Luisa, Meazza, Raffaella, Grapulin, Lavinia, Handgretinger, Rupert, Moretta, Alessandro, Bertaina, Alice, and Moretta, Lorenzo

Published
2017
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29. Allogeneic, donor-derived, second-generation, CD19-CAR-T cell for the treatment of pediatric relapsed/refractory BCP-ALL

Author

del Bufalo, Francesca, primary, Becilli, Marco, additional, Rosignoli, Chiara, additional, De Angelis, Biagio, additional, Algeri, Mattia, additional, Hanssens, Linda, additional, Gunetti, Monica, additional, Iacovelli, Stefano, additional, Li Pira, Giuseppina, additional, Girolami, Elia, additional, Leone, Giovanna, additional, Lazzaro, Stefania, additional, Bertaina, Valentina, additional, Sinibaldi, Matilde, additional, Di Cecca, Stefano, additional, Iaffaldano, Laura, additional, Künkele, Annette, additional, Boccieri, Emilia, additional, Del Baldo, Giada, additional, Pagliara, Daria, additional, Merli, Pietro, additional, Carta, Roberto, additional, Quintarelli, Concetta, additional, and Locatelli, Franco, additional

Published
2023
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31. Outcomes of HLA-mismatched HSCT with TCRαβ/CD19 depletion or post-transplant cyclophosphamide in patients with inborn errors of immunity – an EBMT inborn errors working party analysis

Author

Lum, Su Han, primary, Gilbert, Patrick, additional, Sirait, Tiarlan, additional, Algeri, Mattia, additional, Balashov, Dmitry, additional, Bonfim, Carmem, additional, Gennery, Andrew, additional, Slatter, Mary, additional, Neven, Bénédicte, additional, and Albert, Michael, additional

Published
2023
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32. GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma

Author

Del Bufalo, Francesca, primary, De Angelis, Biagio, additional, Caruana, Ignazio, additional, Del Baldo, Giada, additional, De Ioris, Maria A., additional, Serra, Annalisa, additional, Mastronuzzi, Angela, additional, Cefalo, Maria G., additional, Pagliara, Daria, additional, Amicucci, Matteo, additional, Li Pira, Giuseppina, additional, Leone, Giovanna, additional, Bertaina, Valentina, additional, Sinibaldi, Matilde, additional, Di Cecca, Stefano, additional, Guercio, Marika, additional, Abbaszadeh, Zeinab, additional, Iaffaldano, Laura, additional, Gunetti, Monica, additional, Iacovelli, Stefano, additional, Bugianesi, Rossana, additional, Macchia, Stefania, additional, Algeri, Mattia, additional, Merli, Pietro, additional, Galaverna, Federica, additional, Abbas, Rachid, additional, Garganese, Maria C., additional, Villani, Maria F., additional, Colafati, Giovanna S., additional, Bonetti, Federico, additional, Rabusin, Marco, additional, Perruccio, Katia, additional, Folsi, Veronica, additional, Quintarelli, Concetta, additional, and Locatelli, Franco, additional

Published
2023
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33. Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor

Author

Algeri, Mattia, primary, Velardi, Enrico, additional, Spada, Marco, additional, Galaverna, Federica, additional, Carta, Roberto, additional, Vinti, Luciana, additional, Palumbo, Giuseppe, additional, Gaspari, Stefania, additional, Pietrobattista, Andrea, additional, Boccieri, Emilia, additional, Becilli, Marco, additional, Francalanci, Paola, additional, Bertaina, Valentina, additional, Merli, Pietro, additional, and Locatelli, Franco, additional

Published
2023
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36. Health-related quality of life in patients with steroid-refractory acute graft-versus-host disease

Author

Leeneman, Brenda, Blommestein, Hedwig M., van Dongen-Leunis, Annemieke, Algeri, Mattia, Fibbe, Willem E., Oosten, Liesbeth, Uyl-de Groot, Carin A., Thielen, Frederick W., Leeneman, Brenda, Blommestein, Hedwig M., van Dongen-Leunis, Annemieke, Algeri, Mattia, Fibbe, Willem E., Oosten, Liesbeth, Uyl-de Groot, Carin A., and Thielen, Frederick W.

Abstract

Background: Evidence regarding health-related quality of life (HRQoL) in patients with steroid-refractory acute graft-versus-host disease (SR-aGvHD) is lacking. Evaluating HRQoL was a secondary objective of the HOVON 113 MSC trial. Here we describe the outcomes of the EQ-5D-5L, EORTC QLQ-C30, and FACT-BMT for all adult patients who completed these questionnaires at baseline (i.e., before the start of treatment; n = 26). Methods: Descriptive statistics were used to describe baseline patient and disease characteristics, EQ-5D dimension scores and values, EQ VAS scores, EORTC QLQ-C30 scale/item and summary scores, and FACT-BMT subscale and total scores. Results: The mean EQ-5D value was 0.36. In total, 96% of the patients reported problems with usual activities, 92% with pain/discomfort, 84% with mobility, 80% with self-care, and 72% with anxiety/depression. The mean EORTC QLQ-C30 summary score was 43.50. Mean scale/item scores ranged from 21.79 to 60.00 for functioning scales, from 39.74 to 75.21 for symptom scales, and from 5.33 to 91.67 for single items. The mean FACT-BMT total score was 75.31. Mean subscale scores ranged from 10.09 for physical well-being to 23.94 for social/family well-being. Conclusion: Our study showed that HRQoL in patients with SR-aGvHD is poor. Improving HRQoL and symptom management in these patients should be a top priority.

Published
2023

37. Ruxolitinib as the first post-steroid treatment for acute and chronic graft-versus-host disease.

Author

Algeri, Mattia, Becilli, Marco, and Locatelli, Franco

Subjects
ACUTE diseases, GRAFT versus host disease, STEM cell transplantation, RUXOLITINIB, CHRONIC diseases, STEROID drugs
Abstract

Acute and chronic graft-versus-host disease (GvHD) are potentially life-threatening complications occurring after allogeneic stem cell transplantation (allo-HSCT). Although steroids represent the first-line treatment for both conditions, in those patients who do not adequately benefit from steroid therapy, standardized treatment algorithms are lacking. In recent years, ruxolitinib has emerged as the most promising agent for the second-line therapy of steroid-refractory (SR)-GvHD. This review will summarize the biological properties and the mechanistic aspects that justify the therapeutic role of ruxolitinib in GvHD. In addition, current treatment options for SR-GvHD will be briefly discussed. Finally, results of the most relevant clinical trials on the use of ruxolitinib for SR-GvHD will be analyzed, with a particular focus on two phase-III randomized trials in which ruxolitinib demonstrated its superiority in comparison with the best available therapy. Ruxolitinib has considerably improved the outcome of patients with SR-acute/chronic-GvHD and should be regarded as the standard-of-care option when corticosteroids fail or cannot be tapered. Nevertheless, a number of questions still remain unanswered and significant room for improvement exists. Additional observations derived from a longer follow-up will certainly increase our expertise in the management of this powerful therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Circulating Extracellular Vesicles Impair Mesenchymal Stromal Cell Differentiation Favoring Adipogenic Rather than Osteogenic Differentiation in Adolescents with Obesity

Author

Peruzzi, Barbara, primary, Urciuoli, Enrica, additional, Mariani, Michela, additional, Chioma, Laura, additional, Tomao, Luigi, additional, Montano, Ilaria, additional, Algeri, Mattia, additional, Luciano, Rosa, additional, Fintini, Danilo, additional, and Manco, Melania, additional

Published
2022
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40. Human leukocyte antigen evolutionary divergence influences outcomes of paediatric patients and young adults affected by malignant disorders given allogeneic haematopoietic stem cell transplantation from unrelated donors

Author

Merli, Pietro, primary, Crivello, Pietro, additional, Strocchio, Luisa, additional, Pinto, Rita Maria, additional, Algeri, Mattia, additional, Del Bufalo, Francesca, additional, Pagliara, Daria, additional, Becilli, Marco, additional, Carta, Roberto, additional, Gaspari, Stefania, additional, Galaverna, Federica, additional, Quagliarella, Francesco, additional, Boz, Giulia, additional, Catanoso, Maria Luigia, additional, Boccieri, Emilia, additional, Troiano, Maria, additional, Fleischhauer, Katharina, additional, Andreani, Marco, additional, and Locatelli, Franco, additional

Published
2022
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41. HLA-Haploidentical Stem Cell Transplantation in Children with Inherited Bone Marrow Failure Syndromes: A Retrospective Analysis on Behalf of EBMT Severe Aplastic Anemia Working Party

Author

Giardino, Stefano, primary, Eikema, Dirk-Jan, additional, Piepenbroek, Brian, additional, Algeri, Mattia, additional, Ayas, Mouhab, additional, Faraci, Maura, additional, Tbakhi, Abdelghani, additional, Zecca, Marco, additional, Essa, Mohammed, additional, Neven, Bénédicte, additional, Bertrand, Yves, additional, Kharya, Gaurav, additional, Bykova, Tatiana A, additional, Lawson, Sarah, additional, Petrini, Mario, additional, Mohseny, Alexander, additional, Rialland, Fanny, additional, James, Beki, additional, Colita, Anca, additional, Fahd, Mony, additional, Cesaro, Simone, additional, Schulz, Ansgar, additional, Dufour, Carlo, additional, Risitano, Antonio, additional, and Peffault de Latour, Régis, additional

Published
2022
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42. Mucosal-Associated Invariant T (MAIT) Cells Are Functionally Impaired in Pediatric Patients Following HCT and Their Recovery Is Associated with the Onset of GvHD

Author

Velardi, Enrico, primary, Flamini, Sara, additional, Galaverna, Federica, additional, Boccieri, Emilia, additional, Dolores De Luca, Carmen, additional, Benini, Francesca, additional, Quagliarella, Francesco, additional, Rosichini, Marco, additional, Catanoso, Marialuigia, additional, Cardinale, Antonella, additional, Velardi, Shirley, additional, Volpe, Gabriele, additional, Pitisci, Angela, additional, Coccetti, Marianna, additional, Carta, Roberto, additional, Del Bufalo, Francesca, additional, Bertaina, Valentina, additional, Becilli, Marco, additional, Pagliara, Daria, additional, Algeri, Mattia, additional, Merli, Pietro, additional, and Locatelli, Franco, additional

Published
2022
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43. CAR.CD123-NK Cells Have an Equally Effective but Safer Off-Tumor/on-Target Profile As Compared to CARCD123-T Cells for the Treatment of Acute Myeloid Leukaemia

Author

Caruso, Simona, primary, Quintarelli, Concetta, additional, De Angelis, Biagio, additional, Del Bufalo, Francesca, additional, Ciccone, Roselia, additional, Donsante, Samantha, additional, Volpe, Gabriele, additional, Manni, Simona, additional, Guercio, Marika, additional, Pezzella, Michele, additional, Iaffaldano, Laura, additional, Silvestris, Domenico Alessandro, additional, Sinibaldi, Matilde, additional, Di Cecca, Stefano, additional, Pitisci, Angela, additional, Velardi, Enrico, additional, Merli, Pietro, additional, Algeri, Mattia, additional, Lodi, Mariachiara, additional, Paganelli, Valeria, additional, Serafini, Marta, additional, Riminucci, Mara, additional, and Locatelli, Franco, additional

Published
2022
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45. Updated Analysis on the Outcomes of Children with Acute Leukemia (AL) Receiving an Alpha/Beta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

Author

Merli, Pietro, primary, Algeri, Mattia, additional, Galaverna, Federica, additional, Quagliarella, Francesco, additional, Bertaina, Valentina, additional, Girolami, Elia, additional, Meschini, Antonella, additional, Del Principe, Giovanna, additional, Biagini, Simone, additional, Sborgia, Raffaella, additional, Lucarelli, Barbarella, additional, Pagliara, Daria, additional, Catanoso, Marialuigia, additional, Rosignoli, Chiara, additional, Cossutta, Matilde, additional, Lanzaro, Francesca, additional, Canino, Costanza, additional, Cefalo, Maria Giuseppina, additional, Strocchio, Luisa, additional, Boccieri, Emilia, additional, Becilli, Marco, additional, Carta, Roberto, additional, Del Bufalo, Francesca, additional, Li Pira, Giuseppina, additional, and Locatelli, Franco, additional

Published
2022
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46. Decellularized esophageal tubular scaffold microperforated by quantum molecular resonance technology and seeded with mesenchymal stromal cells for tissue engineering esophageal regeneration

Author

Marzaro, Maurizio, primary, Pozzato, Gianantonio, additional, Tedesco, Stefano, additional, Algeri, Mattia, additional, Pozzato, Alessandro, additional, Tomao, Luigi, additional, Montano, Ilaria, additional, Torroni, Filippo, additional, Balassone, Valerio, additional, Contini, Anna Chiara Iolanda, additional, Guerra, Luciano, additional, D’Angelo, Tommaso, additional, Federici di Abriola, Giovanni, additional, Lupoi, Lorenzo, additional, Caristo, Maria Emiliana, additional, Boškoski, Ivo, additional, Costamagna, Guido, additional, Francalanci, Paola, additional, Astori, Giuseppe, additional, Bozza, Angela, additional, Bagno, Andrea, additional, Todesco, Martina, additional, Trovalusci, Emanuele, additional, Oglio, Luigi Dall’, additional, Locatelli, Franco, additional, and Caldaro, Tamara, additional

Published
2022
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48. αβT- and B-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation in children with myelodysplastic syndromes

Author

Merli, Pietro, primary, Pagliara, Daria, additional, Mina, Tommaso, additional, Bertaina, Valentina, additional, Li Pira, Giuseppina, additional, Lazzaro, Stefania, additional, Biagini, Simone, additional, Galaverna, Federica, additional, Strocchio, Luisa, additional, Carta, Roberto, additional, Catanoso, Maria Luigia, additional, Quagliarella, Francesco, additional, Becilli, Marco, additional, Boccieri, Emilia, additional, Del Bufalo, Francesca, additional, Panigari, Arianna, additional, Agostini, Annalisa, additional, Pedace, Lucia, additional, Pizzi, Simone, additional, Perotti, Cesare, additional, Algeri, Mattia, additional, Zecca, Marco, additional, and Locatelli, Franco, additional

Published
2022
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49. Decellularized esophageal tubular scaffold microperforated by quantum molecular resonance technology and seeded with mesenchymal stromal cells for tissue engineering esophageal regeneration

Author

Marzaro, Maurizio, Pozzato, Gianantonio, Tedesco, Stefano, Algeri, Mattia, Pozzato, Alessandro, Tomao, Luigi, Montano, Ilaria, Torroni, Filippo, Balassone, Valerio, Contini, Anna Chiara Iolanda, Guerra, Luciano, D'Angelo, Tommaso, Federici Di Abriola, Giovanni, Lupoi, Lorenzo, Caristo, Maria Emiliana, Boskoski, Ivo, Costamagna, Guido, Francalanci, Paola, Astori, Giuseppe, Bozza, Angela, Bagno, Andrea, Todesco, Martina, Trovalusci, Emanuele, Dall'Oglio, Luigi, Locatelli, Franco, Caldaro, Tamara, Federici di Abriola, Giovanni, Boskoski, Ivo (ORCID:0000-0001-8194-2670), Costamagna, Guido (ORCID:0000-0002-8100-2731), Oglio, Luigi Dall', Locatelli, Franco (ORCID:0000-0002-7976-3654), Marzaro, Maurizio, Pozzato, Gianantonio, Tedesco, Stefano, Algeri, Mattia, Pozzato, Alessandro, Tomao, Luigi, Montano, Ilaria, Torroni, Filippo, Balassone, Valerio, Contini, Anna Chiara Iolanda, Guerra, Luciano, D'Angelo, Tommaso, Federici Di Abriola, Giovanni, Lupoi, Lorenzo, Caristo, Maria Emiliana, Boskoski, Ivo, Costamagna, Guido, Francalanci, Paola, Astori, Giuseppe, Bozza, Angela, Bagno, Andrea, Todesco, Martina, Trovalusci, Emanuele, Dall'Oglio, Luigi, Locatelli, Franco, Caldaro, Tamara, Federici di Abriola, Giovanni, Boskoski, Ivo (ORCID:0000-0001-8194-2670), Costamagna, Guido (ORCID:0000-0002-8100-2731), Oglio, Luigi Dall', and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

Current surgical options for patients requiring esophageal replacement suffer from several limitations and do not assure a satisfactory quality of life. Tissue engineering techniques for the creation of customized "self-developing" esophageal substitutes, which are obtained by seeding autologous cells on artificial or natural scaffolds, allow simplifying surgical procedures and achieving good clinical outcomes. In this context, an appealing approach is based on the exploitation of decellularized tissues as biological matrices to be colonized by the appropriate cell types to regenerate the desired organs. With specific regard to the esophagus, the presence of a thick connective texture in the decellularized scaffold hampers an adequate penetration and spatial distribution of cells. In the present work, the Quantum Molecular Resonance (R) (QMR) technology was used to create a regular microchannel structure inside the connective tissue of full-thickness decellularized tubular porcine esophagi to facilitate a diffuse and uniform spreading of seeded mesenchymal stromal cells within the scaffold. Esophageal samples were thoroughly characterized before and after decellularization and microperforation in terms of residual DNA content, matrix composition, structure and biomechanical features. The scaffold was seeded with mesenchymal stromal cells under dynamic conditions, to assess the ability to be repopulated before its implantation in a large animal model. At the end of the procedure, they resemble the original esophagus, preserving the characteristic multilayer composition and maintaining biomechanical properties adequate for surgery. After the sacrifice we had histological and immunohistochemical evidence of the full-thickness regeneration of the esophageal wall, resembling the native organ. These results suggest the QMR microperforated decellularized esophageal scaffold as a promising device for esophagus regeneration in patients needing esophageal substitution.

Published
2022

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