377 results on '"Alfonso J. Rodríguez-Morales"'
Search Results
2. Mpox: Risks and approaches to prevention
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Fatma Amer, Hend E.S. Khalil, Mohammed Elahmady, Nissreen E. ElBadawy, Wafaa Ahmed Zahran, Moustafa Abdelnasser, Alfonso J. Rodríguez-Morales, Ahmed A. Wegdan, and Rehab M.Elsaid Tash
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Monkeypox ,Mpox ,Outbreak ,Infection prevention and control ,Risk assessment ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Since early May 2022, an outbreak due to Mpox virus (formerly called monkeypox) has occurred in many countries around the world. On July 23, the World Health Organization declared the outbreak ‘Public Health Emergency of International Concern’. In order to combat the outbreak, it is important to have effective infection prevention and control plans. The first step is to qualitatively and quantitatively determine the risks of infections, followed by the design and implementation of infection prevention and control measures. Mpox is transmitted through direct, indirect, and prolonged contact, through sexual transmission, and via the respiratory route. Men who have sex with men are identified as the most vulnerable population. Home pet-raisers, and health care workers are at risk of catching the disease. The outcome of infection is catastrophic among the elderly, immunocompromised individuals, pregnant female and children. The spillover to animals is of great concern. It is important to communicate the risks and have community engagement in the control of this outbreak. The availability of vaccines will add to the capability of containing the outbreak. It is critical to prevent the virus from spreading further. Hence, we review the recent findings on the risk management of Mpox along with the preventive strategies.
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- 2023
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3. Mapping Bovine Tuberculosis in Colombia, 2001–2019
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D. Katterine Bonilla-Aldana, S. Daniela Jiménez-Diaz, Carlos Lozada-Riascos, Kenneth Silva-Cajaleon, and Alfonso J. Rodríguez-Morales
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tuberculosis ,infection ,cattle ,GIS ,geographic information systems ,Mycobacterium bovis ,Veterinary medicine ,SF600-1100 - Abstract
Introduction: Bovine tuberculosis is a zoonotic disease of significant impact, particularly in countries where a pastoral economy is predominant. Despite its importance, few studies have analysed the disease’s behaviour in Colombia, and none have developed maps using geographic information systems (GIS) to characterise it; as such, we developed this study to describe the temporal–spatial distribution of bovine tuberculosis in Colombia over a period of 19 years. Methods: A retrospective cross-sectional descriptive study, based on reports by the Colombian Agricultural Institute (ICA), surveillance of tuberculosis on cattle farms in Colombia from 2001 to 2019 was carried out. The data were converted into databases using Microsoft Access 365®, and multiple epidemiological maps were generated with the QGIS® version 3.36 software coupled to shape files of all the country’s departments. Results: During the study period, 5273 bovine tuberculosis cases were identified in multiple different departments of Colombia (with a mean of 278 cases/year). Regarding its temporal distribution, the number of cases varied from a maximum of 903 cases (17.12% of the total) in 2015 to a minimum of 0 between 2001 and 2004 and between 2017 and 2019 (between 2005 and 2016, the minimum was 46 cases, 0.87%). Conclusions: GIS are essential for understanding the temporospatial behaviour of zoonotic diseases in Colombia, as is the case for bovine tuberculosis, with its potential implications for the Human and One Health approaches.
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- 2024
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4. Susceptibility to endemic Aedes‐borne viruses among pregnant women in Risaralda, Colombia
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Jaime A. Cardona-Ospina, Adriana M. Trujillo, Erika V. Jiménez-Posada, Juan C. Sepúlveda-Arias, Fredy A. Tabares-Villa, Joanne S. Altieri-Rivera, Alejandro Monsalve, Juliana Restrepo-Chica, Daniela Osorio, Daniel Espinoza, Yerun Zhu, Juan D. Castrillón-Spitia, Valentina Henao-SanMartin, David R. Murillo-Garcia, Natalia Millán, Sandra X. Olaya, Ana M. Valencia-Montoya, Hugo A. Bedoya-Arias, Rhuvi Villamizar-Peña, Estefanía Gutierrez-Ocampo, Yeimer Holguin-Rivera, Isabella Cortés-Bonilla, Maria C. Cardona-Trujillo, Alejandra García-Barco, D. Katterine Bonilla-Aldana, Guillermo J. Lagos-Grisales, Alfonso J. Rodríguez-Morales, and Matthew H. Collins
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Dengue ,Zika ,Chikungunya ,Aedes-borne viruses ,Seroprevalence ,Pregnancy ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: Aedes-borne viruses (ABV) affect humans on every inhabited continent and frequently cause epidemics. Recent epidemics of chikungunya and Zika viruses (ZIKV) highlight that preparedness for future epidemics requires assessment of susceptibility, particularly among high-risk groups. We sought to determine immunity against the three major circulating ABV among pregnant women in an ABV-endemic area of Colombia. Methods: A cross-sectional seroprevalence study was performed, enrolling women presenting to Labor and Delivery. Cord blood and maternal peripheral blood samples were obtained. IgG seroprevalence to flaviviruses and chikungunya was determined by ELISA. An abbreviated neutralization test was used to estimate the frequency and magnitude of immunity to Zika and four dengue serotypes. Cluster analyses explored epidemiologic factors associated with seroprevalence. Results: Most women exhibited high levels of neutralizing antibodies to one or more ABV; however, nearly 20% were seronegative for flaviviruses. Our research took place after the epidemic peak of the ZIKV outbreak in Colombia in 2016. However, only 20% of pregnant women had high levels of Zika-neutralizing antibodies consistent with likely protective immunity to ZIKV. Conclusion: Hence, a high proportion of pregnant women in Risaralda remain susceptible to one or more ABV including the teratogenic ZIKV, indicating a risk for future epidemics in this region.
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- 2022
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5. Vaccine-derived polio in Peru after 32 years of elimination: reflections on the routine childhood immunisation coverages
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Ali Al-kassab-Córdova, Omar Napanga-Saldaña, Ricardo Peña-Sánchez, Alfonso J. Rodríguez-Morales, and Edward Mezones-Holguín
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Public aspects of medicine ,RA1-1270 - Published
- 2023
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6. Diagnostic performance of RT-PCR-based sample pooling strategy for the detection of SARS-CoV-2
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Miguel Hueda-Zavaleta, Cesar Copaja-Corzo, Vicente A. Benites-Zapata, Pedro Cardenas-Rueda, Jorge L. Maguiña, and Alfonso J. Rodríguez-Morales
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COVID-19 ,COVID-19 diagnosis ,Pool testing ,PCR ,RT-PCR ,SARS-CoV-2 ,Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Abstract Background The rapid spread of SARS-CoV-2 has created a shortage of supplies of reagents for its detection throughout the world, especially in Latin America. The pooling of samples consists of combining individual patient samples in a block and analyzing the group as a particular sample. This strategy has been shown to reduce the burden of laboratory material and logistical resources by up to 80%. Therefore, we aimed to evaluate the diagnostic performance of the pool of samples analyzed by RT-PCR to detect SARS-CoV-2. Methods A cross-sectional study of diagnostic tests was carried out. We individually evaluated 420 samples, and 42 clusters were formed, each one with ten samples. These clusters could contain 0, 1 or 2 positive samples to simulate a positivity of 0, 10 and 20%, respectively. RT-PCR analyzed the groups for the detection of SARS-CoV-2. The area under the ROC curve (AUC), the Youden index, the global and subgroup sensitivity and specificity were calculated according to their Ct values that were classified as high (H: ≤ 25), moderate (M: 26–30) and low (L: 31–35) concentration of viral RNA. Results From a total of 42 pools, 41 (97.6%) obtained the same result as the samples they contained (positive or negative). The AUC for pooling, Youden index, sensitivity, and specificity were 0.98 (95% CI, 0.95–1); 0.97 (95% CI, 0.90–1.03); 96.67% (95% CI; 88.58–100%) and 100% (95% CI; 95.83–100%) respectively. In the stratified analysis of the pools containing samples with Ct ≤ 25, the sensitivity was 100% (95% CI; 90–100%), while with the pools containing samples with Ct ≥ 31, the sensitivity was 80% (95% CI, 34.94–100%). Finally, a higher median was observed in the Ct of the clusters, with respect to the individual samples (p
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- 2022
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7. La COVID-19 en Colombia y Venezuela: dos caras de la misma moneda
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Alfonso J. Rodríguez-Morales and Manuel E. Figuera
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Medicine ,Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Published
- 2022
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8. Prevalence and factors associated with the intention to vaccinate against COVID-19 in Peru
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Percy Herrera-Añazco, Ángela Uyen-Cateriano, Diego Urrunaga-Pastor, Guido Bendezu-Quispe, Carlos J. Toro-Huamanchumo, Alfonso J. RodrÍguez-Morales, Adrian V. Hernández, and Vicente A. Benites-Zapata
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infecciones por coronavirus ,betacoronavirus ,vacunación ,negativa a la vacunación ,perú ,Medicine ,Medicine (General) ,R5-920 - Abstract
Objectives: To estimate the prevalence and factors associated with COVID-19 vaccination intention (VI) in Peru. Materials and methods: Analytical cross-sectional study using the survey conducted by the University of Maryland, USA, on Facebook. The dependent variable is VI. Crude and adjusted prevalence ratios (PR) were calculated, with their 95% confidence intervals (95%CI) using generalized linear models of the Poisson family, to evaluate the association of sociodemographic variables, compliance with community mitigation strategies, symptoms of COVID-19, mental health and acceptance of vaccination before the recommendation (AVR) by various actors and health authorities, with the ITV. Results: Data from 17,162 adults were analyzed. The overall prevalence of VI was 74.9%. A lower prevalence of VI was associated with the female sex (PR=0.95; 95%CI:0.94-0.97), living in a town (PR=0.95; 95%CI:0.91-0.99) or village or other rural area (PR=0.90; 95%CI:0.86-0.93) and the AVR of politicians (PR=0.89; 95%CI:0.87-0.92). Conversely, having COVID-19 symptoms (PR=1.06; 95%CI:1.03-1.09), economic insecurity (PR=1.04; 95%CI:1.01-1.06), fears of becoming seriously ill or that a family member becomes seriously ill from COVID-19 (PR=1.49; 95%CI:1.36-1.64) and the AVR of family and friends (PR=1.10; 95%CI: 1.08-1.12), healthcare workers (PR=1.29; 95%CI: 1.26-1.32), World Health Organization (PR=1.34; 95%CI: 1.29-1.40) and government officials (PR=1.18; 95%CI: 1.15-1.22) was associated with a higher prevalence of VI. Conclusions: Three-quarters of the respondents had VI. There are potentially modifiable factors that could improve vaccine acceptance.
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- 2021
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9. Online-synchronized clinical simulation: an efficient teaching-learning option for the COVID-19 pandemic time and: beyond
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Diego Andrés Díaz-Guio, Elena Ríos-Barrientos, Pablo Andrés Santillán-Roldan, Santiago Mora-Martinez, Ana Sofía Díaz-Gómez, Joel Alejandro Martínez-Elizondo, Adrián Barrientos-Aguiñaga, Maria Nathalie Arroyo-Romero, Alejandra Ricardo-Zapata, and Alfonso J. Rodríguez-Morales
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COVID-19 ,SARS-CoV-2 ,Learning ,Clinical simulation ,Telesimulation ,Teledebriefing ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Face-to-face clinical simulation has been a powerful methodology for teaching, learning, and research, and has positioned itself in health science education. However, due to the COVID-19 pandemic, social distancing has forced universities to abandon simulation centers and make use of alternatives that allow the continuation of educational programs safely for students and teachers through virtual environments such as distance simulation. In Latin America, before the pandemic, the use of non-presential simulation was very limited and anecdotal. This article has three main objectives: to establish the efficacy of online-synchronized clinical simulation in the learning and performance of medical students on the management of patients with COVID-19 in simulation centers of three Latin American countries, to determine the quality of the online debriefing from the students’ perspective, and to deepen the understanding of how learning is generated with this methodology.
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- 2021
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10. Frequency of Correct Mask Use Among Pedestrians in High-Flow Indoor Public Spaces: A Multicenter Analysis in the First and Second Waves of the COVID-19 Pandemic in Peru
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Edward Mezones-Holguin, Ali Al-kassab-Córdova, Percy Herrera-Añazco, Vicente Aleixandre Benites-Zapata, Carlos J. Toro-Huamanchumo, Aldo Flores-Gavino, Agueda Muñoz del Carpio-Toia, and Alfonso J. Rodríguez-Morales
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Our study aimed to describe the variation in the frequency of correct mask use among pedestrians in the first and second waves of the COVID-19 pandemic in high-flow indoor public spaces from different geographic and social settings in Peru. Methods: We carried out a cross-sectional exploratory study among pedestrians in Lima (the capital city) and other coastal and highland cities in Peru. Pedestrians were directly observed by trained medical students in 2 high-flow indoor areas at different times in November 2020 (first wave) and October 2021 (second wave). Primary outcomes included the frequencies of mask use and correct use. We applied multinomial logistic models and estimated crude and adjusted relative prevalence ratios for sex, age, obesity, and location. Additionally, we used binomial generalized linear models to estimate prevalence ratios in crude and adjusted models. Results: We included 1996 participants. The frequency of mask use was similar in both years: 96.9% in 2020 and 95.5% in 2021. However, the frequency of correct mask use significantly decreased from 81.9% (95% CI, 79.4-84.3) in 2020 to 60.3% (95% CI, 57.2-67.3) in 2021. In 2020, we observed an increase in the probability of misuse in the cities of Lima (aRP: 1.42; P = .021) and Chiclayo (aPR: 1.62, P = .001), whereas, in 2021, we noted an increase in the probability of misuse in the cities of Lima (aRP: 1.72; P
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- 2022
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11. African swine fever virus: A re-emerging threat to the swine industry and food security in the Americas
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Julian Ruiz-Saenz, Andres Diaz, D. Katterine Bonilla-Aldana, Alfonso J. Rodríguez-Morales, Marlen Martinez-Gutierrez, and Patricia V. Aguilar
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African swine fever ,reservoirs ,Arbovirus ,emerging disease ,pigs ,Microbiology ,QR1-502 - Published
- 2022
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12. Phylodynamic analysis in the understanding of the current COVID-19 pandemic and its utility in vaccine and antiviral design and assessment
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Jaime A. Cardona-Ospina, Diana M. Rojas-Gallardo, Sandra C. Garzón-Castaño, Erika V. Jiménez-Posada, and Alfonso J. Rodríguez-Morales
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sars-cov-2 ,covid-19 ,phylodynamic ,vaccines ,antivirals ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Over the last decades, the use of phylogenetic methods in the study of emerging infectious diseases has gained considerable traction in public health. Particularly, the integration of phylogenetic analyses with the understanding of the pathogen dynamics at the population level has provided powerful tools for epidemiological surveillance systems. In the same way, the development of statistical methods and theory, as well as improvement of computational efficiency for evolutionary analysis, has expanded the use of these tools for vaccine and antiviral development. Today with the Coronavirus Disease 2019 (COVID-19), this seems to be critical. In this article, we discuss how the application of phylodynamic analysis can improve the understanding of current pandemic dynamics as well as the design, selection, and evaluation of vaccine candidates and antivirals.
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- 2021
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13. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry
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Milena S. Marcolino, Patricia K. Ziegelmann, Maira V.R. Souza-Silva, I.J.B. Nascimento, Luana M. Oliveira, Luanna S. Monteiro, Thaís L.S. Sales, Karen B. Ruschel, Karina P.M.P. Martins, Ana Paula B.S. Etges, Israel Molina, Carisi A. Polanczyk, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Lara Rodrigues Monteiro de Barros, Ana Luiza Bahia Alves Scotton, Alfonso J. Rodríguez-Morales, Anderson Lacerda dos Reis, André Soares Moura Costa, Argenil José Assis de Oliveira, Bárbara Lopes Farace, Carla Thais Cândida Alves da Silva, Carolina Marques Ramos, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Daniel Vitório Silveira, Daniela Ponce, Emanuele Marianne Souza Kroger, Euler Roberto Fernandes Manenti, Fernanda Barbosa Lucas, Fernanda d'Athayde Rodrigues, Fernando Anschau, Fernando Antonio Botoni, Frederico Bartolazzi, Gabriela Petry Crestani, Guilherme Fagundes Nascimento, Helena Carolina Noal, Helena Duani, Heloisa Reniers Vianna, Henrique Cerqueira Guimarães, Joice Coutinho de Alvarenga, Júlia Drumond Parreiras de Morais, Juliana Machado Rugolo, Lara Monalyza Gonçalves Franco, Leila Beltrami Moreira, Leonardo Seixas de Oliveira, Lílian Santos Pinheiro, Liliane Souto Pacheco, Luciane Kopittke, Luciano de Souza Viana, Luis Cesar Souto de Moura, Luisa Elem Almeida Santos, Máderson Alvares de Souza Cabral, Maíra Dias Souza, Marcela Gonçalves Trindade Tofani, Marconi Franco da Silveira, Marcus Vinicius de Melo Andrade, Maria Angélica Pires Ferreira, Maria Aparecida Camargos Bicalho, Maria Auxiliadora Parreiras Martins, Maria Clara Pontello Barbosa Lima, Mariana Balbinot Borges, Mariana de Braga Lima Carvalho Canesso, Matheus Carvalho Alves Nogueira, Meire Pereira de Figueiredo, Milton Henriques Guimarães Junior, Mychelle Stefany Santos Almeida, Mônica Aparecida de Paula de Sordi, Natália da Cunha Severino Sampaio, Neimy Ramos de Oliveira, Paulo Tarso Lima Vianna, Pedro Guido Soares Andrade, Pedro Ledic Assaf, Rafael Fusaro Aguiar Oliveira, Rafael Lima Rodrigues de Carvalho, Rafaela dos Santos Charão de Almeida, Raphael Castro Martins, Reginaldo Aparecido Valacio, Ricardo Bertoglio Cardoso, Ricardo Braga Coelho, Roberta Pozza, Rodolfo Lucas Silva Mourato, Rodrigo Costa Pereira Vieira, Roger Mendes de Abreu, Rufino de Freitas Silva, Saionara Cristina Francisco, Silvana Mangeon Mereilles Guimarães, Silvia Ferreira Araújo, Talita Fischer Oliveira, Tatiana de Vargas, Tatiani Oliveira Fereguetti, Thalita Martins Lage, Thulio Henrique Oliveira Diniz, and Veridiana Baldon dos Santos
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COVID-19 ,SARS-CoV-2 ,hospitalizations ,pandemic ,Brazil ,mortality ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. Methods: A cohort study of laboratory-confirmed COVID-19 patients who were hospitalized from March 2020 to September 2020 in 25 hospitals. Data were collected from medical records using Research Electronic Data Capture (REDCap) tools. A multivariate Poisson regression model was used to assess the risk factors for in-hospital mortality. Results: For a total of 2,054 patients (52.6% male; median age of 58 years), the in-hospital mortality was 22.0%; this rose to 47.6% for those treated in the intensive care unit (ICU). Hypertension (52.9%), diabetes (29.2%), and obesity (17.2%) were the most prevalent comorbidities. Overall, 32.5% required invasive mechanical ventilation, and 12.1% required kidney replacement therapy. Septic shock was observed in 15.0%, nosocomial infection in 13.1%, thromboembolism in 4.1%, and acute heart failure in 3.6%. Age >= 65 years, chronic kidney disease, hypertension, C-reactive protein ≥ 100 mg/dL, platelet count < 100 × 109/L, oxygen saturation < 90%, the need for supplemental oxygen, and invasive mechanical ventilation at admission were independently associated with a higher risk of in-hospital mortality. The overall use of antimicrobials was 87.9%. Conclusions: This study reveals the characteristics and in-hospital outcomes of hospitalized patients with confirmed COVID-19 in Brazil. Certain easily assessed parameters at hospital admission were independently associated with a higher risk of death. The high frequency of antibiotic use points to an over-use of antimicrobials in COVID-19 patients.
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- 2021
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14. Monkeypox – a description of the clinical progression of skin lesions: a case report from Colorado, USA
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Yeimer Ortiz-Martínez, Alfonso J. Rodríguez-Morales, Carlos Franco-Paredes, Daniel B. Chastain, Amal A. Gharamti, Lilian Vargas Barahona, and Andrés F. Henao-Martínez
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Infectious and parasitic diseases ,RC109-216 - Abstract
A rapidly emerging global outbreak of monkeypox virus infection (MPXV) in over 50 non-endemic countries was identified in May 2022. We report the case and images of a patient with MPXV presenting with genital lesions later complicated by superimposed cellulitis in Colorado, USA. MPXV lesions are susceptible to bacterial superinfection, and with the advent of new cases, the early identification of skin lesions and their evolution during MPXV are imperative for treating clinicians. Clinicians should consider MPXV in differential diagnoses of sexually transmitted diseases presenting with genital lesions.
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- 2022
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15. Bell’s palsy as a possible neurological complication of COVID‐19: A case report
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Anup Bastola, Ranjit Sah, Gaurav Nepal, Bikram Prasad Gajurel, Sagar Kumar Rajbhandari, Bimal Sharma Chalise, Bikesh Shrestha, Richa Nepal, Kijan Maharjan, Kuldeep Dhama, and Alfonso J. Rodríguez‐Morales.
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Bell’s palsy ,COVID‐19 ,Facial nerve ,Facial palsy ,Neurological complication ,SARS‐CoV‐2 ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract COVID‐19 has been associated with several neurological complications. We presented a case of Bell's palsy as a possible neurological complication of COVID‐19 infection. Further research should be conducted to clarify the association, correlation, or causality between COVID‐19 and neuroimmunological diseases.
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- 2021
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16. Seroprevalence canine survey for selected vector-borne pathogens and its relationship with poverty in metropolitan Pereira, Colombia, 2020
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D. Katterine Bonilla-Aldana, Erwin J. Gutiérrez-Grajales, J. Paola Martínez-Arboleda, María Angelica Reina-Mora, Adrián E. Trejos-Mendoza, Soffia Pérez-Vargas, Lorenzo Valencia-Mejía, Luisa F. Marín-Arboleda, Daniela Osorio-Navia, Mariana Chacón-Peña, Luz Victoria González-Colonia, Jaime A. Cardona-Ospina, Erika Vanessa Jiménez-Posada, Andrés Diaz, Jean Carlos Salazar, Manuel Sierra, Fausto Muñoz-Lara, Lysien I. Zambrano, Eduardo Ramírez-Vallejo, Juan Camilo Álvarez, Ingrid Lorena Jaramillo-Delgado, Samuel Pecho-Silva, Alberto Paniz-Mondolfi, Álvaro A. Faccini-Martínez, and Alfonso J. Rodríguez-Morales
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Anaplasma phagocytophilum ,Anaplasma platys ,Ehrlichia canis ,Ehrlichia ewingii ,Dirofilaria immitis ,Tick-borne diseases ,Infectious and parasitic diseases ,RC109-216 - Abstract
Background: Tick-borne diseases (TBD) and dirofilariosis are currently not under surveillance in most Latin American countries. In addition, there is a significant lack of studies describing the current situation in most endemic areas, including Colombia. Therefore, seroprevalence studies are crucial for understanding the epidemiology of these vector-borne diseases. Methods: A serosurvey for TBD and dirofilariosis among 100 dogs was carried out in the municipality of Pereira, located in the Coffee-Triangle region, Colombia. Samples were tested using a rapid assay test system (SNAP® 4Dx®); based on an enzyme immunoassay technique‚ screening for antibodies to Anaplasma phagocytophilum/platys (sensitivity 99.1%)‚ Borrelia burgdorferi s.l. (98.8%), and Ehrlichia canis/ewingii (96.2%) by using specific antigens and checking for Dirofilaria immitis antigen based on specific antibodies (99.2%). Bivariate analyses were performed on Stata®14, significant p
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- 2022
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17. Human monkeypox preparedness in Latin America – Are we ready for the next viral zoonotic disease outbreak after COVID-19?
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Sergio Cimerman, Alberto Chebabo, Clovis Arns da Cunha, Alexandre Naime Barbosa, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Published
- 2022
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18. High incidence and mortality of COVID-19 among patients with haematological malignancies: an observational study in santander, Colombia
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Yeimer Ortiz-Martínez, Javier E. Fajardo-Rivero, Tania Mendoza-Herrera, Claudia Figueroa-Pineda, Carlos Ruiz-González, Zane Saul, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 - Published
- 2022
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19. What has been researched about monkeypox? a bibliometric analysis of an old zoonotic virus causing global concern
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Alfonso J. Rodríguez-Morales, Yeimer Ortiz-Martínez, and D. Katterine Bonilla-Aldana
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Monkeypox ,orthopoxvirus ,outbreak ,poxviridae ,zoonotic ,Infectious and parasitic diseases ,RC109-216 - Published
- 2022
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20. High seroprevalence for SARS-CoV-2 infection in South America, but still not enough for herd immunity!
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Susy Fanny Núñez-Zapata, Bruno Benites-Peralta, Percy Mayta-Tristan, and Alfonso J. Rodríguez-Morales
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SARS-CoV-2 ,COVID-19 ,Seroprevalence ,Herd immunity ,South America ,Epidemiology ,Infectious and parasitic diseases ,RC109-216 - Abstract
Herd immunity is considered to be a relevant aspect of COVID-19 epidemiology. In this regard, seroprevalence studies are essential for understanding how far countries and regions are from that potential point. This study analyzed seroprevalence data in nine studies from South America, which is a region that has been badly affected by COVID-19. Seroprevalence values were high, with percentages up to 70.0% (95% CI 67.0-73.4%) in Iquitos, Peru. A meta-analysis of such data enabled a pooled seroprevalence to be obtained, estimated at 33.6% (95% CI 28.6-38.5%). Despite this, the COVID-19 pandemic in South America continues to significantly affect countries such as Brazil, Colombia, and Peru.
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- 2021
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21. Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to animals: an updated review
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Sina Salajegheh Tazerji, Phelipe Magalhães Duarte, Parastoo Rahimi, Fatemeh Shahabinejad, Santosh Dhakal, Yashpal Singh Malik, Awad A. Shehata, Juan Lama, Jörn Klein, Muhammad Safdar, Md. Tanvir Rahman, Krzysztof J. Filipiak, Alfonso J. Rodríguez-Morales, Md. Abdus Sobur, Farrokhreza Kabir, Bita Vazir, Leonard Mboera, Marco Caporale, Md. Saiful Islam, John H. Amuasi, Rasha Gharieb, Paola Roncada, Sahar Musaad, Bruno Tilocca, Mohammad Kazem Koohi, Ali Taghipour, Ahmet Sait, Kannan Subbaram, Alireza Jahandideh, Pejman Mortazavi, Mohammad Amin Abedini, David A. Hokey, Unarose Hogan, Mohamed N. F. Shaheen, Ahmed Elaswad, Mahmoud M. Elhaig, and Mohamed Fawzy
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Coronavirus ,COVID-19 ,SARS-CoV-2 ,Pandemic ,Zoonoses ,Pet animals ,Medicine - Abstract
Abstract COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million people with a toll of 0.75 million deaths and restricting the movement of most of the world population during the past 6 months. COVID-19 became the leading health, economic, and humanitarian challenge of the twenty-first century. In addition to the considerable COVID-19 cases, hospitalizations, and deaths in humans, several cases of SARS-CoV-2 infections in animal hosts (dog, cat, tiger, lion, and mink) have been reported. Thus, the concern of pet owners is increasing. Moreover, the dynamics of the disease requires further explanation, mainly concerning the transmission of the virus from humans to animals and vice versa. Therefore, this study aimed to gather information about the reported cases of COVID-19 transmission in animals through a literary review of works published in scientific journals and perform genomic and phylogenetic analyses of SARS-CoV-2 isolated from animal hosts. Although many instances of transmission of the SARS-CoV-2 have been reported, caution and further studies are necessary to avoid the occurrence of maltreatment in animals, and to achieve a better understanding of the dynamics of the disease in the environment, humans, and animals. Future research in the animal–human interface can help formulate and implement preventive measures to combat the further transmission of COVID-19.
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- 2020
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22. Enfermedad por coronavirus 2019 (COVID-19) en América Latina: papel de la atención primaria en la preparación y respuesta
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Jorge A. Sánchez-Duque, Laura R. Arce-Villalobos, and Alfonso J. Rodríguez-Morales
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Medicine (General) ,R5-920 - Published
- 2020
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23. Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin
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José Millán-Oñate, William Millan, Luis Alfonso Mendoza, Carlos Guillermo Sánchez, Hugo Fernandez-Suarez, D. Katterine Bonilla-Aldana, and Alfonso J. Rodríguez-Morales
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Coronavirus Disease 2019 (COVID-19) ,Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) ,Chloroquine ,Colombia ,Latin America ,Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Abstract Background COVID-19 pandemics is a challenge for public health and infectious diseases clinicians, especially for the therapeutical approach that is not yet adequately defined. Amid this situation, investigational agents are being used, including chloroquine. We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. Case presentation A 34-year-old male, returning from Spain, presented with complaints of fever, and cough, and class-II obesity, being hospitalized. The respiratory viruses and bacteria tested by FilmArray® PCR were negative. Two days later, clarithromycin was started because the patient was suspected as community-acquired pneumonia. At the third day, the rRT-PCR confirmed the SARS-CoV-2 infection. A day later, chloroquine was started because of that. His chest computed tomography was performed and showed bilateral multifocal ground-glass opacities with consolidation, which suggested viral pneumonia as a differential diagnosis. Progressively his clinical condition improved and at day 9, patient rRT-PCR for SARS-CoV-2 became negative. The patient was discharged and isolated at home per 14 days. Conclusions Our patient improved significantly. This and other COVID-19 cases are urgently demanding results from clinical trials that support evidence-based therapeutical approaches to this pandemic and the clinical management of patients, especially those at critical care.
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- 2020
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24. Orthohantavirus pulmonary syndrome in Santa Cruz and Tarija, Bolivia, 2018
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Juan Pablo Escalera-Antezana, Roberto Torrez-Fernandez, Dagner Montalvan-Plata, Claudia Marcela Montenegro-Narváez, Jorge Luis Aviles-Sarmiento, Lucia Elena Alvarado-Arnez, D. Katterine Bonilla-Aldana, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction: Orthohantaviruses are still a significant public health threat in endemic countries, with high case fatality rates (CFR). In Bolivia, the reporting of small outbreaks occurred until 2012. The findings of 40 laboratory-confirmed cases diagnosed in two departments are reported herein. Methods: This was an observational, retrospective and cross-sectional study. Data on laboratory-confirmed cases in 2018 were collected from the hospitals and departmental health services (SEDES) of Santa Cruz and Tarija. An ELISA was used for the detection of IgM antibody to hantavirus in the patient blood samples. Results: Forty patients were IgM-positive. The median age of the patients was 24 years (interquartile range 19–41 years) and 72.5% were male. All patients were hospitalized; 57.5% were admitted to the intensive care unit and had cardiopulmonary compromise, with 83% of these presenting acute respiratory distress syndrome and 89.5% of these requiring mechanical ventilation. Six patients died (CFR 15%). Patients 60 years old were more prone to die (odds ratio 10.33, 95% confidence interval 1.411–75.694), as were those with comorbidities (odds ratio 16.5, 95% confidence interval 1.207–225.540). Conclusions: Orthohantavirus infections were associated with a high CFR. These cases occurred in areas with eco-epidemiological conditions facilitating viral transmission, including the presence of rodents, as well as the risk of spillover to humans due to social, environmental, and occupational factors. Keywords: Orthohantavirus, New World, Epidemiology, Pulmonary syndrome, Bolivia
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- 2020
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25. EPIDEMIOLOGIA E FATORES PREDITIVOS DE INFECÇÕES FÚNGICAS INVASIVAS EM PACIENTES COM LEUCEMIA
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Yeimer Ortiz-martinez, Javier E. Fajardo-Rivero, Tania Mendoza-Herrera, Carlos Ruiz, Claudia Figueroa-Pineda, Yuderleys Masías, Daniela Moreno-Moreno, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Introdução: A infecção fúngica invasiva (IFI) continua sendo uma causa importante de hospitalização e mortalidade entre pacientes com leucemia. No entanto, há dados limitados de estudos de IFI em pacientes com neoplasias hematológicas na América Latina, portanto, este estudo foi desenhado com o objetivo de investigar a prevalência, epidemiologia, fatores preditivos e desfechos de IFI em pacientes com leucemia hospitalizados em quartos sem Filtro HEPA (configurações com recursos limitados) em um centro de referência na Colômbia. Métodos: Os dados clínicos de pacientes hospitalizados com leucemia foram recuperados retrospectivamente durante um período de 6 anos no centro de referência de hematologia da Colômbia em Bucaramanga, Santander. Prevalência, fatores preditores de IFI e resultados dos pacientes foram avaliados. Resultados: Em 92 pacientes, a prevalência de IFI comprovada/provável foi de 27,17% (25 casos). 10 foram causados por espécies de Candida (40%), seguidos por oito por Aspergillus spp. (32%), dois por Mucor spp. (8%), dois por Penicillium spp. (8%), um por Zygomycetes spp., Fusarium spp. e Trichosporon asahii (4% respectivamente). O pulmão foi o local mais comumente afetado (n = 20; 80%); três pacientes (12%) desenvolveram sinusite fúngica e 2 pacientes (8%) IFI disseminado. Após análise multivariada, o sinal do halo na TC e neutropenia com duração superior a 20 dias foram identificados como fatores associados a maior risco de IFI e a profilaxia com voriconazol ou posaconazol foi associada a uma menor ocorrência de IFI. Foi observada maior taxa de mortalidade hospitalar entre os pacientes que desenvolveram IFI comprovada/provável em comparação com pacientes não IFI (88,0% vs. 56,7%; p = 0,006). Conclusão: os pacientes com leucemia em locais com recursos limitados têm uma alta prevalência de IFI provável/comprovada (27%) com alta mortalidade (88%). O uso de profilaxia antifúngica com voriconazol e posaconazol foi associado a uma prevalência significativamente menor de IFI. Estratégias de diagnóstico e prevenção de infecções devem ser adotadas e implementadas para prevenir IFIs, especialmente em países da América Latina para melhorar os resultados clínicos de pacientes com leucemia.
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- 2022
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26. Haematological Alterations Associated with Selected Vector-Borne Infections and Exposure in Dogs from Pereira, Risaralda, Colombia
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D. Katterine Bonilla-Aldana, Erwin J. Gutiérrez-Grajales, Daniela Osorio-Navia, Mariana Chacón-Peña, Adrián E. Trejos-Mendoza, Soffia Pérez-Vargas, Lorenzo Valencia-Mejía, Luisa F. Marín-Arboleda, J. Paola Martínez-Hidalgo, María Angelica Reina-Mora, Luz Victoria González-Colonia, Jaime A. Cardona-Ospina, Erika Vanessa Jiménez-Posada, Diego Andrés Diaz-Guio, Jean Carlos Salazar, Manuel Sierra, Fausto Muñoz-Lara, Lysien I. Zambrano, Eduardo Ramírez-Vallejo, Juan Camilo Álvarez, Ingrid Lorena Jaramillo-Delgado, Samuel Pecho-Silva, Alberto Paniz-Mondolfi, Álvaro A. Faccini-Martínez, and Alfonso J. Rodríguez-Morales
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Anaplasma phagocytophilum ,Anaplasma platys ,Ehrlichia canis ,Ehrlichia ewingii ,Dirofilaria immitis ,complete blood counts ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Infections due to Ehrlichia, Anaplasma, Dirofilaria, Mycoplasma, Babesia and Hepatozoon continue to be highly prevalent in dogs, especially in tropical and subtropical areas, where vectors of many of them are present. However, many clinical aspects of dogs have not been characterized in detail, including assessing the haematological alterations associated with them, particularly in Colombia and Latin America. A group of 100 dogs with Ehrlichia, Anaplasma, Dirofilaria, Mycoplasma, Babesia and Hepatozoon infections/exposure were assessed by blood smear serology (SNAP4DX) and PCR in Pereira, Colombia. We performed blood counts to evaluate anaemia, leukopenia/leukocytosis, neutropenia, neutrophilia, lymphopenia/lymphocytosis, monocytosis, eosinophilia, and thrombocytopenia, among other alterations. Bivariate analyses were performed on Stata®14, with significant p < 0.05. From the total, 85% presented ≥1 infection (past or present), 66% with coinfections (≥2 pathogens) (Ehrlichia 75%), and 89% presented clinical alterations. A total of 100% showed anaemia, 70% thrombocytopenia, 61% monocytosis, and 47% neutropenia, among other alterations. Additionally, 11% presented pancytopenia and 59% bicytopenia. The median platelet count was lower in infected dogs (126,000 cells/μL) versus non-infected (221,000 cells/μL) (p = 0.003). Thrombocytopenia was higher among infected dogs (75%) versus non-infected (40%) (p = 0.006), with a 91% positive predictive value for infection. Median neutrophil count was lower in infected dogs (6591 cells/μL) versus non-infected (8804 cells/μL) (p = 0.013). Lymphocytosis occurred only among those infected (27%) (p = 0.022). Leukopenia was only observed among infected dogs (13%). Pancytopenia was only observed among infected dogs. Ehrlichiosis and other hematic infections have led to a significant burden of haematological alterations on infected dogs, including pancytopenia in a tenth of them, most with thrombocytopenia and all anemic.
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- 2022
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27. Should we be concerned about Venezuelan hemorrhagic fever? – A reflection on its current situation in Venezuela and potential impact in Latin America amid the migration crisis
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Alfonso J. Rodríguez-Morales, D. Katterine Bonilla-Aldana, Alejandro Risquez, Alberto Paniz-Mondolfi, and José Antonio Suárez
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Guanarito virus ,reemerging ,rodent-borne diseases ,Venezuelan hemorrhagic fever ,zoonoses ,Infectious and parasitic diseases ,RC109-216 - Abstract
Venezuelan Haemorrhagic Fever is an endemic zoonosis exhibiting a high lethality. Discovered decades ago, it is still causing seasonal hemorrhagic fever outbreaks. With the ongoing migration crisis, transmission and spreading to other countries in Latin America remains a latent threat that should be monitored, particularly in light of recent cases.
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- 2021
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28. Toxoplasmosis congénita: la importancia de la adherencia a las guías y las implicaciones clínicas en Colombia
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Jorge L. Alvarado-Socarras, Andrea Zárate, Alfonso J. Rodríguez-Morales, Carlos F. Guerrero, and John M. Giraldo
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Toxoplasmosis. Toxoplasmosis congénita. Toxoplasmosis cerebral. Colombia. ,Pediatrics ,RJ1-570 ,Public aspects of medicine ,RA1-1270 - Abstract
Introducción: La toxoplasmosis congénita continúa siendo un problema de salud pública. Aun cuando existen guías plenamente divulgadas y conocidas, se observa poca implementación de ellas en algunas instituciones de salud y una inadecuada interpretación de las pruebas serológicas en las gestantes. Esto puede generar falta de captación y tratamiento en embarazadas con primoinfección por Toxoplasma gondii. Casos clínicos: Se reportan dos casos de toxoplasmosis congénita, uno de ellos con desenlace fatal. En ambos no se siguieron las guías de práctica clínica, lo cual conllevó un diagnóstico tardío y, en consecuencia, un manejo en condiciones inapropiadas con daños graves. Conclusiones: La toxoplasmosis es una infección congénita aún prevalente en algunos países, con secuelas graves, discapacidad neurológica y riesgo de daño ocular, incluso tardío. Además, existen algunas variedades de cepas de T. gondii con un comportamiento más agresivo en Latinoamérica, lo cual empeora la presentación de los casos e incluye mayor riesgo de muerte.
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- 2021
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29. More Evidence about Monkeypox Sexual Transmission in the Current 2022 Multi-Country Outbreak. Reply to Vera et al. Comment on 'Sah et al. Monkeypox and Its Possible Sexual Transmission: Where Are We Now with Its Evidence? Pathogens 2022, 11, 924'
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Abdullah Reda, Ranjit Sah, and Alfonso J. Rodríguez-Morales
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n/a ,Medicine - Abstract
We want to thank Milagros N. Vera and colleagues [...]
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- 2022
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30. Assessment of Post-Dengue Rheumatic Symptoms Using the WOMAC and DAS-28 Questionnaires in a Honduran Population after a Four-Month Follow-Up
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Lysien I. Zambrano, Itzel Carolina Fuentes-Barahona, Ricardo Portillo-Pineda, Melissa Aguilar-Ponce, José Carlos Murillo-Padilla, Marlen Suazo-Menocal, Cesar Antunez-Salgado, Edissa Medina-Bassilet, Fausto Muñoz-Lara, D. Katterine Bonilla-Aldana, Juan J. Montenegro-Idrogo, and Alfonso J. Rodríguez-Morales
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arthritis ,arbovirus infections ,dengue ,joint ,arthralgia ,Honduras ,Medicine - Abstract
Introduction: Alphaviruses may cause arthritis, but there is a lack of studies assessing it in flaviviruses such as dengue. Through the 28 Joint Disease Activity Score (DAS-28), incorporating swollen joint counts, and through the Arthritis Index from Western Ontario and McMaster Universities (WOMAC), we assessed pain, stiffness, and dimensions of arthritic function in post-DENV patients. Methods: Prospective study of a cohort of participants who were diagnosed with dengue in centres in Honduras from December 2019 to February 2020, with a follow-up period of 4 months to evaluate post-dengue rheumatological disease through the WOMAC and DAS-28 questionnaires. Results: After a four-month follow-up phase with 281 participants, the final cohort comprised 58.8% women and 41.20% men. After the follow-up, 63.02% persisted with the clinical findings. According to WOMAC, joint involvement was higher in women with (58.76%) (p < 0.0001) these symptoms or functional limitations when performing daily activities were limited to pain when walking (34.81% vs. 5.51%), climbing or descending stairs (36.46% vs. 8.66%), and at night at bedtime (28.73% vs. 7.08%). With the DAS-28, we found at least one alteration with inflammation or pain in 14.91% of the participants, primarily women (p < 0.01). Discussion: Joint involvement was high during the dengue epidemic in 2019. We observed a significant proportion of women with inflammation and joint pain, showing that dengue may lead to the development of chronic rheumatological findings, although lower than in CHIKV, still affecting everyday life and, consequently, their quality of life. Additional long-term evaluation studies after dengue are required.
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- 2022
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31. Dengue Prediction in Latin America Using Machine Learning and the One Health Perspective: A Literature Review
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Maritza Cabrera, Jason Leake, José Naranjo-Torres, Nereida Valero, Julio C. Cabrera, and Alfonso J. Rodríguez-Morales
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dengue ,climate change ,one health ,machine learning ,epidemiology ,prediction ,Medicine - Abstract
Dengue fever is a serious and growing public health problem in Latin America and elsewhere, intensified by climate change and human mobility. This paper reviews the approaches to the epidemiological prediction of dengue fever using the One Health perspective, including an analysis of how Machine Learning techniques have been applied to it and focuses on the risk factors for dengue in Latin America to put the broader environmental considerations into a detailed understanding of the small-scale processes as they affect disease incidence. Determining that many factors can act as predictors for dengue outbreaks, a large-scale comparison of different predictors over larger geographic areas than those currently studied is lacking to determine which predictors are the most effective. In addition, it provides insight into techniques of Machine Learning used for future predictive models, as well as general workflow for Machine Learning projects of dengue fever.
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- 2022
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32. Non-recommended medical interventions and their possible harm in patients with COVID-19
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Samuel Pecho-Silva, Ana Claudia Navarro-Solsol, Vicky Panduro-Correa, Ali A. Rabaan, D. Katterine Bonilla-Aldana, Alfonso J. Rodríguez-Morales, and Kovy Arteaga-Livias
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Infectious and parasitic diseases ,RC109-216 - Published
- 2021
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33. Deep impact of COVID-19 in the healthcare of Latin America: the case of Brazil
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Sergio Cimerman, Alberto Chebabo, Clovis Arns da Cunha, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Published
- 2020
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34. Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019
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Swati Chand, Sangharsha Thapa, Shelley Kon, Steven C. Johnson, Eric M. Poeschla, Carlos Franco-Paredes, Alfonso J. Rodríguez-Morales, Salim Mattar, and Andrés F. Henao-Martínez
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hantavirus ,Seoul virus ,viruses ,acute kidney injury ,proteinuria ,Colorado ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
In North America, hantaviruses commonly cause hantavirus pulmonary syndrome (HPS). Clinical descriptions of hantavirus-associated renal disease in the Americas are scarce. Herein, we discuss the case of a 61-year-old man whose predominant manifestations were acute kidney injury and proteinuria. Clinical recognition of renal signs in hantavirus infections can reduce risk for death.
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- 2020
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35. Knowledge and attitude towards pregnancy-related issues of Zika virus infection among general practitioners in Indonesia
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Harapan Harapan, Yogambigai Rajamoorthy, Prattama S. Utomo, Samsul Anwar, Abdul M. Setiawan, Alma Alleta, Alfredo Bambang, Muhammad R. Ramadana, Ikram Ikram, Nur Wahyuniati, Reza Maulana, Ichsan Ichsan, Rosaria Indah, Abram L. Wagner, Ulrich Kuch, David A. Groneberg, Alfonso J. Rodríguez-Morales, Mohd Andalas, Ruth Müller, Mudatsir Mudatsir, and Allison Imrie
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Zika virus ,Knowledge ,Attitude ,General practitioner ,Healthcare worker ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background The aim of this study was to assess the knowledge and attitudes towards pregnancy-related issues of Zika virus (ZIKV) infection among general practitioners (GPs), a frontline healthcare worker group, in Indonesia. Methods A cross-sectional, online survey assessing knowledge and attitudes towards ZIKV infection on multiple-item scales was sent to GPs in the Sumatra and Java islands of Indonesia. The associations between independent factors and either knowledge or attitude were assessed with logistic regressions. The correlation and association between knowledge and attitude were estimated. Results We included 457 (53.7%) out of 850 responses in the analysis. Among these, 304 (66.5%) and 111 (24.2%) respondents had a good knowledge and attitude, respectively. No demographic, workplace, professional development, or experiential characteristics related to ZIKV infection were associated with knowledge. In the multivariate analysis, only contact experience was associated with attitude. There was a significant, positive correlation between knowledge and attitude scores. Conclusions Although knowledge of pregnancy-related complications of ZIKV infection is relatively high among GPs in Indonesia, more than 75% of them had a poor attitude towards pregnancy-related issues of Zika. Strategies for enhancing the capacity of GPs to develop positive attitudes and respond to ZIKV infection are needed.
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- 2019
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36. Migration crisis in Venezuela and its impact on HIV in other countries: the case of Colombia
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Alfonso J. Rodríguez-Morales, D. Katterine Bonilla-Aldana, Miguel Morales, José A. Suárez, and Ernesto Martínez-Buitrago
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Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Published
- 2019
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37. One year after the arrival of COVID-19 in Latin America: what have we learned in Brazil and other countries?
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Sergio Cimerman, Alberto Chebabo, Clovis Arns da Cunha, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Published
- 2021
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38. Routine Immunization Programs for Children during the COVID-19 Pandemic in Ecuador, 2020—Hidden Effects, Predictable Consequences
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Gianina Lizeth Suárez-Rodríguez, José Salazar-Loor, Jackson Rivas-Condo, Alfonso J. Rodríguez-Morales, Juan-Carlos Navarro, and José Rubén Ramírez-Iglesias
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routine immunization ,vaccination ,infants ,pandemic ,COVID19 ,preventable diseases ,Medicine - Abstract
The COVID-19 pandemic has led to a global disruption of several services, including routine immunizations. This effect has been described in several countries, but there are few detailed studies in Latin America and no reports in Ecuador. Therefore, this work aims to quantify the reduction in routine immunizations for infants during the 2020 COVID-19 pandemic in Ecuador. 2018, 2019, and 2020 data were obtained from the Ministry of Health, Ecuador. The number of doses and the extent of immunization coverage was descriptively compared for four vaccines: rotavirus (ROTA), poliovirus (PV), pneumococcal (PCV), and pentavalent (PENTA) vaccines. There was no significant difference in doses applied during the 2018 and 2019 years. However, a significant (p < 0.05) drop of 137,000 delivered doses was observed in 2020 compared to the pre-pandemic years. Reductions in the percentage of coverage were more pronounced for the PENTA vaccine (17.7%), followed by PV (16.4%), ROTA (12%), and PCV vaccines (10.7%). Spatial analysis shows a severe impact on vaccination coverage on provinces from the Coast and Highland regions of the country. The pandemic has significantly impacted the immunization programs for infants across Ecuador. This retrospective analysis shows an urgent need to protect vulnerable zones and populations during public health emergencies.
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- 2022
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39. Attitudes towards Zika virus infection among medical doctors in Aceh province, Indonesia
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Harapan Harapan, Alma Alleta, Samsul Anwar, Abdul M. Setiawan, Reza Maulana, Nur Wahyuniati, Muhammad R. Ramadana, Ikram Ikram, Sotianingsih Haryanto, Kurnia F. Jamil, Ulrich Kuch, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Zika virus (ZIKV) infection, a public health emergency of international concern, has recently been confirmed in Indonesia. However, to date, there has been no study to assess how prepared healthcare workers in Indonesia are to confront this emerging infectious disease. The aim of this study was to assess the attitudes of medical doctors in Indonesia towards ZIKV infection and its associated explanatory variables. A cross-sectional self-administered online survey was conducted from 3 May to 3 June 2016 in Aceh province, Indonesia. A pre-tested questionnaire was used to collect data on doctors’ attitudes towards ZIKV infection and a range of explanatory variables (basic demographic data, professional characteristics, workplace characteristics and facilities, and medical experience related to ZIKV infection). Associations between attitude and explanatory variables were assessed using multiple-step logistic regression. We received 631 responses, 424 (67.19%) of which were included in the final analysis. Approximately 64% (271) of doctors had a poor attitude towards ZIKV infection. Experience considering ZIKV infection as a differential diagnosis and attendance at a national conference was associated with a good attitude, with odds ratios (OR) of 3.93 (95% confidence interval [CI]: 1.15–13.49) and 1.69 (95% CI: 1.03–2.76), respectively. Unexpectedly, doctors who had attended an international conference and those working at places that had molecular diagnostic (polymerase chain reaction based testing) facilities had lower odds of having a good attitude (OR: 0.35 [95% CI: 0.15–0.84] and 0.42 [95% CI: 0.19–0.95], respectively). In conclusion, the attitude towards ZIKV infection is relatively poor among doctors in Aceh. Therefore, strategies for enhancing their capacity to respond to ZIKV infection are needed. The survey concept and tools were well accepted by the participants of this study, suggesting that this rapid assessment could be rolled out across the Indonesian archipelago and elsewhere to identify and regionally differentiate unmet needs of disease and outbreak preparedness. Keywords: Zika virus, Zika fever, Attitude, Healthcare worker, Indonesia
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- 2018
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40. Urinary bladder agenesis and renal hypoplasia potentially related to in utero Zika virus infection
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Wilmer E. Villamil-Gómez, Dionny Padilla-Ruiz, Anibal Mendoza, Álvaro Álvarez, Oldrih Baldrich-Gomez, Heidi Posso, Myrna Campo-Urbina, Edgar A. Parra-Saad, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 - Abstract
This case report describes the clinical findings of a 22-year-old pregnant woman with confirmed Zika virus infection, at 16 weeks of gestation, in Sucre, Colombia. Her ultrasound revealed severe oligohydramnios, intrauterine growth restriction, and a complete absence of the urinary bladder of the fetus. The poor prognosis led to the decision to terminate the pregnancy. Autopsy of the fetus revealed severe bilateral renal hypoplasia. Keywords: Zika, Birth defects, Urinary bladder, Agenesis, Renal hypoplasia, Colombia
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- 2019
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41. Prevención e identificación temprana de casos sospechosos COVID-19 en el primer nivel de atención en Centro América
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Karla Iveth Henriquez-Marquez, Lysien I. Zambrano, Kovy Arteaga-Livias, and Alfonso J. Rodríguez-Morales
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Medicine (General) ,R5-920 - Published
- 2021
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42. Estimating and mapping the incidence of dengue and chikungunya in Honduras during 2015 using Geographic Information Systems (GIS)
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Lysien I. Zambrano, Manuel Sierra, Bredy Lara, Iván Rodríguez-Núñez, Marco T. Medina, Carlos O. Lozada-Riascos, and Alfonso J. Rodríguez-Morales
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Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Geographical information systems (GIS) use for development of epidemiological maps in dengue has been extensively used, however not in other emerging arboviral diseases, nor in Central America. Surveillance cases data (2015) were used to estimate annual incidence rates of dengue and chikungunya (cases/100,000 pop) to develop the first maps in the departments and municipalities of Honduras. The GIS software used was Kosmo Desktop 3.0RC1®. Four thematic maps were developed according departments, municipalities, diseases incidence rates. A total of 19,289 cases of dengue and 85,386 of chikungunya were reported (median, 726 cases/week for dengue and 1460 for chikungunya). Highest peaks were observed at weeks 25th and 27th, respectively. There was association between progression by weeks (p 37%, both). Use of GIS-based epidemiological maps allow to guide decisions-taking for prevention and control of diseases that still represents significant issues in the region and the country, but also in emerging conditions. Keywords: Dengue, Chikungunya, Arboviruses, Infectious diseases epidemiology, Honduras
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- 2017
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43. The dilemmas of the classification of SARS-CoV-2 infection without clinical manifestations: Asymptomatic or presymptomatic
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Kovy Arteaga-Livias, Samuel Pecho-Silva, Vicky Panduro-Correa, and Alfonso J. Rodríguez-Morales
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Medicine (General) ,R5-920 - Published
- 2020
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44. Rasmussen aneurysm: A rare but not gone complication of tuberculosis
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Ángela María Giraldo-Montoya, Alfonso J. Rodríguez-Morales, Juan David Hernández-Hurtado, Álvaro López-Salazar, Guillermo J. Lagos-Grisales, and Víctor H. Ruiz-Granada
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Infectious and parasitic diseases ,RC109-216 - Abstract
This report describes the case of a 30-year-old homeless man from Pereira, Colombia with tuberculosis, who presented with massive hemoptysis and associated aneurysm of the left upper lobe (Rasmussen aneurysm). Computed tomography angiography with three-dimensional reconstruction confirmed the aneurysm, and embolization was performed successfully. Keywords: Tuberculosis, Complications, Aneurysm, Colombia
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- 2018
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45. Zika, dengue, and chikungunya co-infection in a pregnant woman from Colombia
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Wilmer E. Villamil-Gómez, Alfonso J. Rodríguez-Morales, Ana María Uribe-García, Edgardo González-Arismendy, Jaime E. Castellanos, Eliana P. Calvo, Melchor Álvarez-Mon, and Didier Musso
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Dengue ,Chikungunya ,Zika ,Co-infection ,Pregnancy ,Infectious and parasitic diseases ,RC109-216 - Abstract
The clinical findings of a pregnant woman from Colombia with a triple co-infection caused by dengue, chikungunya, and Zika viruses are described. Weekly obstetric ultrasounds from 14.6 to 29 weeks of gestation were normal. She remains under follow-up and management according to the standard guidelines for the management of Zika virus-infected pregnant women.
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- 2016
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46. Estimating and mapping the incidence of giardiasis in Colombia, 2009–2013
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Alfonso J. Rodríguez-Morales, Santiago Granados-Álvarez, Harold Escudero-Quintero, Felipe Vera-Polania, Alvaro Mondragon-Cardona, Fredi Alexander Díaz-Quijano, Leonardo Sosa-Valencia, Carlos O. Lozada-Riascos, Angel A. Escobedo, Olivia Liseth, and Ubydul Haque
- Subjects
Giardiasis ,Protozoan ,Parasitic ,Infectious diseases epidemiology ,Colombia ,Infectious and parasitic diseases ,RC109-216 - Abstract
Background: Giardiasis is one of the most common intestinal infections in the world. There have been no national studies on the morbidity of giardiasis in Colombia. In this study, incidence rates of giardiasis were estimated for the years 2009–2013. Methods: An observational, retrospective study of the giardiasis incidence in Colombia, 2009–2013, was performed using data extracted from the personal health records system (Registro Individual de Prestación de Servicios, RIPS). Official population estimates from the National Department of Statistics (DANE) were used for the estimation of crude and adjusted incidence rates (cases/100 000 population). Results: During the period studied, 15 851 cases were reported (median 3233/year; 5-year cumulated crude national rate of 33.97 cases/100 000 population). Of these, 50.3% were female; 58.4% were
- Published
- 2016
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- View/download PDF
47. Severe and benign Plasmodium vivax malaria in Emberá (Amerindian) children and adolescents from an endemic municipality in Western Colombia
- Author
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Diego A. Medina-Morales, Estefanía Montoya-Franco, Viviana d.P. Sanchez-Aristizabal, Jorge E. Machado-Alba, and Alfonso J. Rodríguez-Morales
- Subjects
Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Malaria in children is still an important public health problem in endemic areas of South-East Asia and Latin America. Certain forms of the disease, such as Plasmodium vivax severe malaria, are still neglected. This descriptive study assessed the frequency of severe and benign P. vivax infection in Emberá children (
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- 2016
- Full Text
- View/download PDF
48. Pin-Site Myiasis Caused by Screwworm Fly in Nonhealed Wound, Colombia
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Wilmer E. Villamil-Gómez, Jaime A. Cardona-Ospina, Juan Sebastián Prado-Ojeda, Hugo Hernández-Prado, Mauricio Figueroa, Pedro N. Causil-Morales, Keirim Pérez-Reyes, Leidy A. Palechor-Ocampo, and Alfonso J. Rodríguez-Morales
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myiasis ,pin-site ,Cochliomyia hominivorax ,complication ,chronic infection ,screwworm fly ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Pin-site myiasis is an underreported complication of surgical interventions. We present a case of myiasis caused by the New World screwworm fly (Cochliomyia hominivorax) in a pin site of a chronic nonhealed wound 12 years after the intervention. This infection apparently was the result of poor perfusion of the leg.
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- 2019
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49. Trachoma in 3 Amerindian Communities, Venezuelan Amazon, 2018
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Oscar Noya-Alarcón, Maríapía Bevilacqua, and Alfonso J. Rodríguez-Morales
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Trachoma ,Chlamydia trachomatis ,blindness ,neglected tropical diseases ,Venezuela ,indigenous population ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Trachoma is among the most common infectious causes of blindness. During January–May 2018, a total of 4 trachoma cases were diagnosed among Amerindians of the Yanomami ethnic group in 3 communities of southern Venezuela. This country has social and environmental conditions conducive to the endemicity of this neglected tropical disease.
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- 2019
- Full Text
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50. Mapping malaria in municipalities of the Coffee Triangle region of Colombia using Geographic Information Systems (GIS)
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Alfonso J. Rodríguez-Morales, César A. Orrego-Acevedo, Yazmin Zambrano-Muñoz, Francisco J. García-Folleco, Albert C. Herrera-Giraldo, and Carlos O. Lozada-Riascos
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Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Geographical Information Systems (GIS) have been used extensively for the development of epidemiological maps of malaria but not in the Coffee Triangle region of Colombia, endemic for P. vivax, P. falciparum and P. malariae. Surveillance case data (2007–2011) were used to estimate annual incidence rates per Plasmodium spp. (cases/100,000 pop) to develop the first malaria maps in the 53 municipalities of this region (departments Caldas, Quindío, Risaralda). The GIS software used was Kosmo Desktop 3.0RC1®. Thirty thematic maps were developed according to the municipalities, years, parasite etiology, and uncomplicated and complicated cases. A total of 6582 cases were reported (6478 uncomplicated and 104 complicated, 77.8% Risaralda), for a cumulated rate of 269.46 cases/100,000 pop. Among uncomplicated cases, 5722 corresponded to P. vivax (234.25 cases/100,000 pop), 475 to P. falciparum (19.45 cases/100,000 pop), 8 to P. malariae (0.33 cases/100,000 pop) and 273 mixed (P. falciparum/P. vivax) (11.18 cases/100,000 pop). The highest rate reported was in the more undeveloped and rural municipality of Risaralda (Pueblo Rico, 57.7 cases/1000 pop, 2009). The burden of disease was concentrated in one department (>75% of the region). The use of GIS-based epidemiological maps helps to guide decision-making for the prevention and control of this public health problem that still represents a significant issue in the region and the country, particularly in children. Keywords: Malaria, Geographic Information Systems, Maps, Epidemiology, Colombia
- Published
- 2015
- Full Text
- View/download PDF
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