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1. Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Author

Crivelli, Adriana N., Muñiz, Hector Solar, Chapman, Brooke R., Jones, Lynn, O'Callaghan, Margie, Osland, Emma, Hodgson, Ruth, Wallin, Siobhan, Lasenby, Kay, Van Gossum, Andre, Won Lee, Andre Dong, Doitchinova-Simeonova, Maryana, Krznaric, Zeljko, Rasmussen, Henrik Højgaard, Brandt, Chrisoffer, Jeppesen, Palle B., Chambrier, Cecile, Joly, Francisca, Boehm, Vanessa, Bataille, Julie, Billiauws, Lore, Poullenot, Florian, Schneider, Stéphane M., Seguy, David, Thibault, Ronan, Arends, Jann, Czako, Laszlo, Molnar, Tomas, Zsilak-Urban, Mihaly, Izbéki, Ferenc, Sahin, Peter, Udvarhelyi, Gábor, Schafer, Eszter, Theilla, Miriam, Sasdelli, Anna Simona, Brillanti, Giorgia, Nardi, Elena, Pironi, Loris, Aimasso, Umberto, Dario, Merlo F., Bertasi, Valentino, Masconale, Luisa, Guglielmi, Francesco W., Regano, Nunzia, Orlandoni, Paolo, Lidia, Santarpia, Alfonsi, Lucia, Spaggiari, Corrado, Taus, Marina, Busni, Debora, Kekstas, Gintautas, Serralde-Zúñiga, Aurora E., Gillanders, Lyn, Kunecki, Marek, Matras, Przemysław, Matysiak, Konrad, Szczepanek, Kinga, Zmarzly, Anna, Kozjek, Nada Rotovnik, Bueno, Marta, Cuerda, Cristina, Garde, Carmen, Virgili, Nuria M., Olveira, Gabriel, Jáuregui, M<ce:sup loc='post">a</ce:sup> Estrella Petrina, Sanz-Paris, Alejandro, Suárez-Llanos, José P., Murillo, Ana Zugasti, Ellegard, Lars, Serlie, Mireille, Jonker, Cora, Wanten, Geert, Cooper, Sheldon C., Daniels, Joanne, Di Caro, Simona, Keane, Niamh, Patel, Pinal, Forbes, Alastair, Nelson Hughes, Sarah-Jane, Jukes, Amelia, Lloyd, Rachel, Lal, Simon, Abraham, Arun, Garside, Gerda, Taylor, Michael, Wu, Jian, Smith, Trevor, Pither, Charlotte, Stroud, Michael, Wyer, Nicola, Parmar, Reena, Burch, Nicola, Zeraschi, Sarah, Compher, Charlene, Mundi, Manpreet, Jezerski, Denise, Steiger, Ezra, Sasdelli, Anna S., Mundi, Manpreet S., Rasmussen, Henrik H., Crivelli, Adriana, Santarpia, Lidia, Van Gossum, Andrè, Chapman, Brooke, Won Lee, Andre D., Díez, Marta Bueno, Jáuregui, Mª Estrella Petrina, and Youssef, Nader N.

Published
2021
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10. Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Author

Pironi, Loris, primary, Steiger, Ezra, additional, Joly, Francisca, additional, Jeppesen, Palle B., additional, Wanten, Geert, additional, Sasdelli, Anna S., additional, Chambrier, Cecile, additional, Aimasso, Umberto, additional, Mundi, Manpreet S., additional, Szczepanek, Kinga, additional, Jukes, Amelia, additional, Theilla, Miriam, additional, Kunecki, Marek, additional, Daniels, Joanne, additional, Serlie, Mireille, additional, Poullenot, Florian, additional, Cooper, Sheldon C., additional, Rasmussen, Henrik H., additional, Compher, Charlene, additional, Seguy, David, additional, Crivelli, Adriana, additional, Santarpia, Lidia, additional, Guglielmi, Francesco W., additional, Kozjek, Nada Rotovnik, additional, Schneider, Stéphane M., additional, Ellegard, Lars, additional, Thibault, Ronan, additional, Matras, Przemysław, additional, Matysiak, Konrad, additional, Van Gossum, Andrè, additional, Forbes, Alastair, additional, Wyer, Nicola, additional, Taus, Marina, additional, Virgili, Nuria M., additional, O'Callaghan, Margie, additional, Chapman, Brooke, additional, Osland, Emma, additional, Cuerda, Cristina, additional, Udvarhelyi, Gábor, additional, Jones, Lynn, additional, Won Lee, Andre D., additional, Masconale, Luisa, additional, Orlandoni, Paolo, additional, Spaggiari, Corrado, additional, Díez, Marta Bueno, additional, Doitchinova-Simeonova, Maryana, additional, Serralde-Zúñiga, Aurora E., additional, Olveira, Gabriel, additional, Krznaric, Zeljko, additional, Czako, Laszlo, additional, Kekstas, Gintautas, additional, Sanz-Paris, Alejandro, additional, Jáuregui, Mª Estrella Petrina, additional, Murillo, Ana Zugasti, additional, Schafer, Eszter, additional, Arends, Jann, additional, Suárez-Llanos, José P., additional, Youssef, Nader N., additional, Brillanti, Giorgia, additional, Nardi, Elena, additional, Lal, Simon, additional, Crivelli, Adriana N., additional, Muñiz, Hector Solar, additional, Chapman, Brooke R., additional, Hodgson, Ruth, additional, Wallin, Siobhan, additional, Lasenby, Kay, additional, Van Gossum, Andre, additional, Won Lee, Andre Dong, additional, Rasmussen, Henrik Højgaard, additional, Brandt, Chrisoffer, additional, Boehm, Vanessa, additional, Bataille, Julie, additional, Billiauws, Lore, additional, Molnar, Tomas, additional, Zsilak-Urban, Mihaly, additional, Izbéki, Ferenc, additional, Sahin, Peter, additional, Sasdelli, Anna Simona, additional, Pironi, Loris, additional, Dario, Merlo F., additional, Bertasi, Valentino, additional, Regano, Nunzia, additional, Lidia, Santarpia, additional, Alfonsi, Lucia, additional, Busni, Debora, additional, Gillanders, Lyn, additional, Zmarzly, Anna, additional, Bueno, Marta, additional, Garde, Carmen, additional, Jáuregui, Ma Estrella Petrina, additional, Jonker, Cora, additional, Di Caro, Simona, additional, Keane, Niamh, additional, Patel, Pinal, additional, Nelson Hughes, Sarah-Jane, additional, Lloyd, Rachel, additional, Abraham, Arun, additional, Garside, Gerda, additional, Taylor, Michael, additional, Wu, Jian, additional, Smith, Trevor, additional, Pither, Charlotte, additional, Stroud, Michael, additional, Parmar, Reena, additional, Burch, Nicola, additional, Zeraschi, Sarah, additional, Mundi, Manpreet, additional, and Jezerski, Denise, additional

Published
2021
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19. Cardiac Changes in Patients on Long-Term Parenteral Nutrition

Author

Santarpia, Lidia, primary, Esposito, Roberta, additional, Vaccaro, Andrea, additional, Alfonsi, Lucia, additional, Pagano, Maria Carmen, additional, Santoro, Ciro, additional, Marra, Maurizio, additional, Contaldo, Franco, additional, Galderisi, Maurizio, additional, and Pasanisi, Fabrizio, additional

Published
2019
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24. Essential Amino Acid Profile in Parenteral Nutrition Mixtures: Does It Meet Needs?

Author

Iacone, Roberto, primary, Scanzano, Clelia, additional, Santarpia, Lidia, additional, Alfonsi, Lucia, additional, Marra, Maurizio, additional, Pagano, Maria, additional, D’Isanto, Anna, additional, Frangipane, Ignazio, additional, Vitalone, Andrea, additional, D’Angeli, Mariana, additional, Contaldo, Franco, additional, and Pasanisi, Fabrizio, additional

Published
2018
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25. Impaired Enterohormone Response Following a Liquid Test Meal in Gastrectomized Patients.

Author

Santarpia, Lidia, Pagano, Maria Carmen, Cioffi, Iolanda, Alfonsi, Lucia, Cuomo, Rosario, Labruna, Giuseppe, Sacchetti, Lucia, Contaldo, Franco, and Pasanisi, Fabrizio

Subjects
CHOLECYSTOKININ, ENTERAL feeding, GASTRECTOMY, GASTROINTESTINAL hormones, INSULIN, PEPTIDE hormones, SATISFACTION, STATISTICAL significance, DESCRIPTIVE statistics
Abstract

Background: Total gastrectomy (TG) is responsible for symptoms or disturbance of alimentary status (changes in body weight, food intake per meal and frequency of meal per day) which, in turn are responsible for weight loss and malnutrition. The study evaluates the gut hormone responses in totally gastrectomized (TG) patients after a liquid meal test. Methods: Twenty total gastrectomized cancer-free patients (12 M, 8 F, 56.4 ± 10.2 years, BMI 21.4 ± 2.2 kg/m2) and 10 healthy volunteers (4 M, 6 F, 48.0 ± 12.7 years, BMI 26.7 ± 3.0 kg/m2 ) drank a liquid meal (1.25 kcal/mL) at the rate of 50 mL/5′ min for a maximum of 30 min. Satiety score was assessed and blood sample was taken at different time points. Results: The time response course, particularly for insulin glucose-like pepetide-1, and cholecystokinin, significantly differed between TG patients and controls. Conclusions: Our results may help to better understand hormone responses triggered by the faster arrival of nutrients in the small bowel and to explain some post-TG symptoms. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Essential Amino Acid Profile in Parenteral Nutrition Mixtures: Does It Meet Needs?

Author

Maurizio Marra, Mariana D’Angeli, Maria Carmen Pagano, A. D'Isanto, Roberto Iacone, Lucia Alfonsi, Fabrizio Pasanisi, Lidia Santarpia, C. Scanzano, Andrea Vitalone, I. Frangipane, Franco Contaldo, Iacone, Roberto, Scanzano, Clelia, Santarpia, Lidia, Alfonsi, Lucia, Marra, Maurizio, Pagano, Maria Carmen, D’Isanto, Anna, Frangipane, Ignazio, Vitalone, Andrea, D’Angeli, Mariana, Contaldo, Franco, and Pasanisi, Fabrizio

Subjects
0301 basic medicine, Male, Whey protein, Parenteral Nutrition, isoleucine, chemistry.chemical_compound, 0302 clinical medicine, Methionine, branched-chain amino acids, Essential amino acid, chemistry.chemical_classification, Nutrition and Dietetics, Chemistry, Middle Aged, Short bowel syndrome, essential amino acids, Female, Parenteral Nutrition, Total, Leucine, Bioelectrical impedance analysis, lcsh:Nutrition. Foods and food supply, Adult, Short Bowel Syndrome, 030209 endocrinology & metabolism, lcsh:TX341-641, Article, 03 medical and health sciences, Young Adult, Animal science, medicine, Humans, Branched-chain amino acid, Muscle, Skeletal, Aged, Retrospective Studies, Parenteral Nutrition Solutions, 030109 nutrition & dietetics, Body Weight, Nutritional Requirements, whey protein, medicine.disease, Parenteral nutrition, Whey Proteins, Amino Acids, Essential, Isoleucine, Amino Acids, Branched-Chain, Food Science
Abstract

Background and Aims: The study compares the essential amino acid (EAA) composition of different parenteral nutrition (PN) mixtures with whey protein EAA profile and the theoretical daily EAA requirements (set by WHO/FAO/UNU or IAAO method). According to the individual EAA profile, the potential effect of several PN mixtures was evaluated on the skeletal muscle mass (SMM) of patients on home PN. Methods: Eight AA solutions and fifteen complete PN mixtures were considered. Twenty-nine clinically stable patients with short bowel syndrome on home total PN were retrospectively evaluated. SMM was estimated by bioelectrical impedance analysis. Results: The prescribed doses of EAA that showed a significant increase in home PN patients muscle mass were considerably greater than the theoretical ones, showing an EAA profile similar to whey protein. At the daily dose of 1 g of total AA s/kg body weight (BW), the considered PN mixtures mostly failed to improve SMM. Only prescribed doses which included more than 0.25 g/kg BW of total BCAA with at least 0.10 g/kg BW leucine, 0.08 g/kg BW isoleucine, and 0.06 g/kg BW methionine showed a significant increase in SMM. Conclusions: The theoretical daily requirement for each EAA was met by all considered PN solutions when the prescribed daily dose of total AAs was set at 1 g/kg BW. Nevertheless, our data suggest that only an increase in total BCAA, also richer in single AA leucine, isoleucine, and methionine, is associated with the maintenance and/or increase of SMM. According to these preliminary observations, we support the prescription of an EAA composition of PN mixtures close to that of whey protein for the preservation of SMM in patients on long-term total PN.

Published
2018

31. New Predictive Equations for Estimating Resting Energy Expenditure in Adults With Crohn's Disease.

Author

Marra M, Cioffi I, Morlino D, Vincenzo OD, Pagano MC, Imperatore N, Alfonsi L, Santarpia L, Castiglione F, Scalfi L, and Pasanisi F

Subjects
Adolescent, Adult, Aged, Basal Metabolism, Body Mass Index, Calorimetry, Indirect, Energy Metabolism, Female, GTP-Binding Proteins, Humans, Male, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Young Adult, Crohn Disease
Abstract

Background: Increased resting energy expenditure (REE) has been hypothesized to be a potential cause of weight loss in individuals with Crohn's disease (CD). This study aimed to develop and validate new predictive equations for estimating REE in adults with CD., Methods: Adults, ages 18-65 years, with CD were recruited. Anthropometry, indirect calorimetry, and bioimpedance analysis were performed in all patients. Disease activity was assessed by Crohn's Disease Activity Index. The new predictive equations were generated using different regression models. Prediction accuracy of the new equations was assessed and compared with the most commonly used equations., Results: A total of 270 CD patients (159 males, 111 females) were included and randomly assigned to the calibration (n = 180) and validation groups (n = 90). REE was directly correlated with weight and bioimpedance index, whereas the relation with both age and disease activity was inverse. The new equations were suitable for estimating REE at population level (bias: -0.2 and -0.3, respectively). Individual accuracy was good in both models (≥80%, respectively), especially in females; and similar results were shown by some of the selected equations. But, when accuracy was set within ±5%, the new equations gave the highest prediction., Conclusion: The new, disease-specific, equations for predicting REE in individuals with CD give a good prediction accuracy as far as those proposed in the literature for the general population. However, the new ones performed better at the individual level. Further studies are needed to verify the reliability and usefulness of these new equations., (© 2020 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals, Inc. on behalf of American Society for Parenteral and Enteral Nutrition.)

Published
2020
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32. A patient with oeosinophilic gastroenteritis and severe malnutrition improved with home parenteral nutrition.

Author

Santarpia L, Cuomo R, Camera L, Alfonsi L, Contaldo F, and Pasanisi F

Subjects
Enteritis diagnosis, Enteritis therapy, Eosinophilia diagnosis, Eosinophilia therapy, Gastritis diagnosis, Gastritis therapy, Humans, Male, Malnutrition therapy, Young Adult, Enteritis complications, Eosinophilia complications, Gastritis complications, Malnutrition etiology, Parenteral Nutrition, Home
Abstract

Oeosinophilic gastroenteritis is a chronic and rare disorder characterised by massive oeosinophilic tissue infiltration involving one or more segments of the digestive tract. The management of patients with oeosinophilic gastroenteritis is complex and the therapeutic response often poor. Here we discuss the clinical case and management of a 23-year-old man with oeosinophilic gastroenteritis since the first year of life and the decision to prescribe lifelong total parenteral nutrition.

Published
2010
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33. Central venous catheter infections and antibiotic therapy during long-term home parenteral nutrition: an 11-year follow-up study.

Author

Santarpia L, Alfonsi L, Tiseo D, Creti R, Baldassarri L, Pasanisi F, and Contaldo F

Subjects
Bacterial Infections epidemiology, Bacterial Infections etiology, Drug Resistance, Bacterial, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Mycoses drug therapy, Mycoses epidemiology, Mycoses etiology, Prevalence, Staphylococcal Infections drug therapy, Staphylococcal Infections epidemiology, Staphylococcus epidermidis, Anti-Bacterial Agents therapeutic use, Bacterial Infections drug therapy, Catheterization, Central Venous adverse effects, Catheters, Indwelling adverse effects, Parenteral Nutrition, Home adverse effects
Abstract

Background: Catheter-related bloodstream infections are a serious and common complication in patients receiving home parenteral nutrition (HPN)., Methods: Prevalence of infections, type of agents, and effectiveness of antibiotic therapy were evaluated in 296 patients (133 males, 163 females; mean age 58.2 +/- 13.5 years) receiving HPN for at least 3 months, from January 1995 to December 2006. Patients underwent 99,969 (331 +/- 552; minimum 91, maximum 4353) days of catheterization, corresponding to 93,236 (311 +/- 489; minimum 52, maximum 4353) days of HPN., Results: Fifty-two patients (24 males and 28 females; 35 oncological and 17 nononcological) were diagnosed with 169 infections. The overall corresponding infection rate was 2.0 per 1000 days of catheterization, with a progressive, regular decrease with time. In 30 cases, immediate central venous catheter removal was necessary. Infections were eradicated in 103 of 139 (74%) cases. As to the most common causative agent, 86 (51%) infections were due to Staphylococcus epidermidis. Of these, 64 were treated from 1995 to 2004, 57 of them (89%) successfully; 22 were treated from 2005 onward, only 7 of them (32%) successfully., Conclusions: Although the global infection rate has progressively decreased over the years, S epidermidis has shown an alarming increase in resistance to antibiotic treatment in the last 2 years, suggesting the need for strategies to prevent central venous catheter infection.

Published
2010
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