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2. Is pizza sutable to type 1 diabetes? A real life identification of best compromise between taste and low glycemic index in patients on insulin pump

Author

Brancato, C., Corigliano, M., Cozzolino, G., Fasolino, A., Improta, M.R., Lambersi, C., Martino, C., Mosca, C., Oliva, D., Stile, L.A., Vecchiato, A., Vetrano, A., Visconti, E., Battipaglia, D., Cecco, I., Della Monica, E., Di Capua, M.G., Palmieri, C., Procida, R., Romano, C., Viesti, F., Gentile, S., Della-Corte, T., Di Blasi, V., Guarino, G., Lamberti, C., Vaia, S., Satta, E., Alfarone, C., and Strollo, F.

Published
2020
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3. Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey

Author

Nordio, M., Reboldi, G., Di Napoli, A., Quintaliani, G., Alberici, F., Postorino, M., Aucella, F., Messa, P., Brunori, G., Bosco, M., Malberti, F., Mandreoli, M., Mazzaferro, S., Movilli, E., Ravera, M., Salomone, M., Santoro, D., Postorinolimido, M. A., Bonomini, M., Stingone, A., Maccarone, M., Di Loreto, E., Stacchiotti, L., Malandra, R., Chiarella, S., D'Agostino, F., Fuiano, G., Nicodemo, L., Bonofiglio, R., Greco, S., Mallamaci, F., Barreca, E., Caserta, C., Bruzzese, V., Galati, D., Tramontana, D., Viscione, M., Chiuchiolo, L., Tuccillo, S., Sepe, M., Vitale, F., Ciriana, E., Martignetti, V., Caserta, D., Stizzo, A., Romano, A., Iulianiello, G., Cascone, E., Minicone, P., Chiricone, D., Delgado, G., Barbato, A., Celentano, S., Molfino, I., Coppola, S., Raiola, I., Abategiovanni, M., Borrelli, S., Margherita, C., Bruno, F., Ida, M., Aliperti, E., Potito, D., Cuomo, G., De Luca, M., Merola, M., Botta, C., Garofalo, G., Alinei, P., Paglionico, C., Roano, M., Vitale, S., Ierardi, R., Fimiani, V., Conte, G., Di Natale, G., Romano, M., Di Marino, V., Scafarto, A., Meccariello, S., Pecoraro, C., Di Stazio, E., Di Meglio, E., Cuomo, A., Maresca, B., Rotaia, E., Capasso, G., Auricchio, M., Pluvio, C., Maddalena, L., De Maio, A., Palladino, G., Buono, F., Gigliotti, G., Mancini, E., La Manna, G., Storari, A., Mosconi, G., Cappelli, G., Scarpioni, R., Gregorini, M., Rigotti, A., Mancini, W., Bianco, F., Boscutti, G., Amici, G., Tosto, M., Fini, R., Pace, G., Cioffi, A., Boccia, E., Di Lullo, L., Di Zazzo, G., Simonelli, R., Bondatti, F., Miglio, L., Rifici, N., Treglia, A., Muci, M., Baldinelli, G., Rizzi, E., Lonzi, M., De Cicco, C., Forte, F., De Paolis, P., Grandaliano, Giuseppe, Cuzziol, C., Torre, V. M., Sfregola, P., Rossi, V., Fabio, G., Flammini, A., Filippini, A., Onorato, L., Vendola, F., Di Daniela, N., Alfarone, C., Scabbia, L., Ferrazzano, M., Grotta, B. D., Gamberini, M., Fazzari, L., Mene, P., Morgia, A., Catucci, A., Palumbo, R., Puliti, M., Marinelli, R., Polito, P., Marrocco, F., Morabito, S., Rocca, R., Nazzaro, L., Lavini, R., Iamundo, V., Chiappini, M., Casarci, M., Morosetti, M., Hassan, S., Firmi, G., Galliani, M., Serraiocco, M., Feriozzi, S., Valentini, W., Sacco, P., Garibotto, G., Cappelli, V., Saffioti, C., Repetto, M., Rolla, D., Lorenz, M., Pedrini, L., Polonioli, D., Galli, E., Ruggenenti, P., Scolari, F., Bove, S., Costantino, E., Bracchi, M., Mangano, S., Depetri, G., La Milia, V., Farina, M., Zecchini, S., Savino, R., Melandri, M., Guastoni, C., Paparella, M., Gallieni, M., Minetti, E., Bisegna, S., Righetti, M., Badalamenti, S., Alberghini, E., Bertoli, S., Fabbrini, P., Albrizio, P., Rampino, T., Colturi, C., Rombola, G., Lucatello, A., Guerrini, E., Ranghino, A., Lenci, F., Fanciulli, E., Santarelli, S., Damiani, C., Garofalo, D., Sopranzi, F., Santoferrara, A., Di Luca, M., Galiotta, P., Brigante, M., Manganaro, M., Maffei, S., Berto, I., Besso, L., Viglino, G., Cusinato, S., Chiarinottichiappero, D. F., Tognarelli, G., Gianoglio, B., Forneris, G., Biancone, L., Savoldi, S., Vitale, C., Boero, R., Filiberti, O., Borzumati, M., Gesualdo, L., Lomonte, C., Gernone, G., Pallotta, G., Di Paolo, S., Vernaglione, L., Specchio, A., Stallone, G., Dell'Aquila, R., Sandri, G., Russo, F., Napoli, M., Marangi, A., Morrone, L., Di Stratis, C., Fresu, A., Cicu, F., Murtas, S., Manca, O., Pani, A., Pilloni, M., Pistis, R., Cadoni, M., Contu, B., Logias, F., Ivaldi, R., Fancello, S., Cossu, M., Lepori, G., Vittoria, S., Battiati, E., Arnone, M., Rome, M., Barbera, A., Granata, A., Collura, G., Dico, C. L., Pugliese, G., Di Natale, E., Rizzari, G., Cottone, L., Longo, N., Battaglia, G., Marcantoni, C., Giannetto, G., Tumino, G., Randazzo, F., Bellissimo, L., Faro, F. L., Grippaldi, F., Urso, S., Quattrone, G., Todaro, I., Vincenzo, D., Murgo, A., Masuzzo, M., Pisacane, A., Monardo, P., Pontorierro, M., Quari, C., Bauro, A., Chimenz, R. R., Alfio, D., Girasole, F., Cascio, A. L., Caviglia, A., Tornese, F., Sirna, F., Altieri, C., Cusumano, R., Saveriano, V., La Corte, A., Locascio, G., Rotolo, U., Musso, S., Risuglia, L., Blanco, G., Minardo, G., Castellino, S., Zappulla, Z., Randone, S., Di Francesca, M., Cassetti, C. C., Oddo, G., Buscaino, G., Mucaria, F., Barraco, V. I., Di Martino, A., Rallo, D., Dani, L., Campolo, G., Manescalchi, F., Biagini, M., Agate, M., Panichi, V., Casani, A., Traversari, L., Garosi, G., Tabbi, M., Selvi, A., Cencioni, L., Fagugli, R., Timio, F., Leveque, A., Manes, M., Mennella, G., Calo, L., Fiorini, F., Abaterusso, C., Calzavara, P., Meneghel, G., Bonesso, C., Gambaro, G., Gammaro, L., Rugiu, C., Ronco, C., Nordio M., Reboldi G., Di Napoli A., Quintaliani G., Alberici F., Postorino M., Aucella F., Messa P., Brunori G., Bosco M., Malberti F., Mandreoli M., Mazzaferro S., Movilli E., Ravera M., Salomone M., Santoro D., PostorinoLimido M.A., Bonomini M., Stingone A., Maccarone M., Di Loreto E., Stacchiotti L., Malandra R., Chiarella S., D'Agostino F., Fuiano G., Nicodemo L., Bonofiglio R., Greco S., Mallamaci F., Barreca E., Caserta C., Bruzzese V., Galati D., Tramontana D., Viscione M., Chiuchiolo L., Tuccillo S., Sepe M., Vitale F., Ciriana E., Martignetti V., Caserta D., Stizzo A., Romano A., Iulianiello G., Cascone E., Minicone P., Chiricone D., Delgado G., Barbato A., Celentano S., Molfino I., Coppola S., Raiola I., Abategiovanni M., Borrelli S., Margherita C., Bruno F., Ida M., Aliperti E., Potito D., Cuomo G., De Luca M., Merola M., Botta C., Garofalo G., Alinei P., Paglionico C., Roano M., Vitale S., Ierardi R., Fimiani V., Conte G., Di Natale G., Romano M., Di Marino V., Scafarto A., Meccariello S., Pecoraro C., Di Stazio E., Di Meglio E., Cuomo A., Maresca B., Rotaia E., Capasso G., Auricchio M., Pluvio C., Maddalena L., De Maio A., Palladino G., Buono F., Gigliotti G., Mancini E., La Manna G., Storari A., Mosconi G., Cappelli G., Scarpioni R., Gregorini M., Rigotti A., Mancini W., Bianco F., Boscutti G., Amici G., Tosto M., Fini R., Pace G., Cioffi A., Boccia E., Di Lullo L., Di Zazzo G., Simonelli R., Bondatti F., Miglio L., Rifici N., Treglia A., Muci M., Baldinelli G., Rizzi E., Lonzi M., De Cicco C., Forte F., De Paolis P., Grandaliano G., Cuzziol C., Torre V.M., Sfregola P., Rossi V., Fabio G., Flammini A., Filippini A., Onorato L., Vendola F., Di Daniela N., Alfarone C., Scabbia L., Ferrazzano M., Grotta B.D., Gamberini M., Fazzari L., Mene P., Morgia A., Catucci A., Palumbo R., Puliti M., Marinelli R., Polito P., Marrocco F., Morabito S., Rocca R., Nazzaro L., Lavini R., Iamundo V., Chiappini M., Casarci M., Morosetti M., Hassan S., Firmi G., Galliani M., Serraiocco M., Feriozzi S., Valentini W., Sacco P., Garibotto G., Cappelli V., Saffioti C., Repetto M., Rolla D., Lorenz M., Pedrini L., Polonioli D., Galli E., Ruggenenti P., Scolari F., Bove S., Costantino E., Bracchi M., Mangano S., Depetri G., La Milia V., Farina M., Zecchini S., Savino R., Melandri M., Guastoni C., Paparella M., Gallieni M., Minetti E., Bisegna S., Righetti M., Badalamenti S., Alberghini E., Bertoli S., Fabbrini P., Albrizio P., Rampino T., Colturi C., Rombola G., Lucatello A., Guerrini E., Ranghino A., Lenci F., Fanciulli E., Santarelli S., Damiani C., Garofalo D., Sopranzi F., Santoferrara A., Di Luca M., Galiotta P., Brigante M., Manganaro M., Maffei S., Berto I., Besso L., Viglino G., Cusinato S., ChiarinottiChiappero D.F., Tognarelli G., Gianoglio B., Forneris G., Biancone L., Savoldi S., Vitale C., Boero R., Filiberti O., Borzumati M., Gesualdo L., Lomonte C., Gernone G., Pallotta G., Di Paolo S., Vernaglione L., Specchio A., Stallone G., Dell'Aquila R., Sandri G., Russo F., Napoli M., Marangi A., Morrone L., Di Stratis C., Fresu A., Cicu F., Murtas S., Manca O., Pani A., Pilloni M., Pistis R., Cadoni M., Contu B., Logias F., Ivaldi R., Fancello S., Cossu M., Lepori G., Vittoria S., Battiati E., Arnone M., Rome M., Barbera A., Granata A., Collura G., Dico C.L., Pugliese G., Di Natale E., Rizzari G., Cottone L., Longo N., Battaglia G., Marcantoni C., Giannetto G., Tumino G., Randazzo F., Bellissimo L., Faro F.L., Grippaldi F., Urso S., Quattrone G., Todaro I., Vincenzo D., Murgo A., Masuzzo M., Pisacane A., Monardo P., Pontorierro M., Quari C., Bauro A., Chimenz R.R., Alfio D., Girasole F., Cascio A.L., Caviglia A., Tornese F., Sirna F., Altieri C., Cusumano R., Saveriano V., La Corte A., Locascio G., Rotolo U., Musso S., Risuglia L., Blanco G., Minardo G., Castellino S., Zappulla Z., Randone S., Di Francesca M., Cassetti C.C., Oddo G., Buscaino G., Mucaria F., Barraco V.I., Di Martino A., Rallo D., Dani L., Campolo G., Manescalchi F., Biagini M., Agate M., Panichi V., Casani A., Traversari L., Garosi G., Tabbi M., Selvi A., Cencioni L., Fagugli R., Timio F., Leveque A., Manes M., Mennella G., Calo L., Fiorini F., Abaterusso C., Calzavara P., Meneghel G., Bonesso C., Gambaro G., Gammaro L., Rugiu C., and Ronco C.

Subjects
Male, Contextual analysis, medicine.medical_treatment, Population, 030232 urology & nephrology, Recursive partitioning, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Classification tree, COVID-19, Renal replacement therapy, Risk Factors, Medical, Surveys and Questionnaires, Health care, medicine, Settore MED/14 - NEFROLOGIA, Humans, education, Pandemics, Societies, Medical, Female, Italy, Nephrology, education.field_of_study, business.industry, Multilevel model, Decision rule, Confidence interval, Original Article, Hemodialysis, business, Contextual analysi, Societies, Demography
Abstract

Background and aim: Over 80% (365/454) of the nation’s centers participated in the Italian Society of Nephrology COVID-19 Survey. Out of 60,441 surveyed patients, 1368 were infected as of April 23rd, 2020. However, center-specific proportions showed substantial heterogeneity. We therefore undertook new analyses to identify explanatory factors, contextual effects, and decision rules for infection containment. Methods: We investigated fixed factors and contextual effects by multilevel modeling. Classification and Regression Tree (CART) analysis was used to develop decision rules. Results: Increased positivity among hemodialysis patients was predicted by center location [incidence rate ratio (IRR) 1.34, 95% confidence interval (CI) 1.20–1.51], positive healthcare workers (IRR 1.09, 95% CI 1.02–1.17), test-all policy (IRR 5.94, 95% CI 3.36–10.45), and infected proportion in the general population (IRR 1.002, 95% CI 1.001–1.003) (all p < 0.01). Conversely, lockdown duration exerted a protective effect (IRR 0.95, 95% CI 0.94–0.98) (p < 0.01). The province-contextual effects accounted for 10% of the total variability. Predictive factors for peritoneal dialysis and transplant cases were center location and infected proportion in the general population. Using recursive partitioning, we identified decision thresholds at general population incidence ≥ 229 per 100,000 and at ≥ 3 positive healthcare workers. Conclusions: Beyond fixed risk factors, shared with the general population, the increased and heterogeneous proportion of positive patients is related to the center’s testing policy, the number of positive patients and healthcare workers, and to contextual effects at the province level. Nephrology centers may adopt simple decision rules to strengthen containment measures timely.

Published
2021

4. Waves of infection and waves of communication: the importance of sharing in the era of Covid-19

Author

Mazzaferro, S., Rocca, A. R., Bagordo, D., Alfarone, C., Baldinelli, G., Boccia, E., Bondatti, F., Casarci, M., Catucci, A. E., Chiappini, M. G., Cioffi, A., Cuzziol, C., De Paolis, P., Della Grotta, B., Daniele, N. D., Di Lullo, L., Di Pietro, G., Di Zazzo, G., Fazzari, L., Feriozzi, S., Ferrazzano, M., Filippini, A., Fini, R., Firmi, G., Flammini, A., Forte, F., Galliani, M., Gamberini, M., Gangeri, F., Grandaliano, Giuseppe, Iamundo, V., Lavini, R., Lonzi, M., Marinelli, R., Marrocco, F., Mene, P., Miglio, L., Morabito, S., Morgia, A., Morosetti, M., Muci, M. L., Nazzaro, L., Nusca, C., Onorato, L., Pace, G., Palumbo, R., Pantano, L., Polito, P., Puliti, M., Rifici, N., Rizzi, E., Rossi, V., Sabry, H., Scabbia, L., Serraiocco, M., Sfregola, P., Simonelli, R., Treglia, A., Umbro, I., Valentini, W., Grandaliano G. (ORCID:0000-0003-1213-2177), Mazzaferro, S., Rocca, A. R., Bagordo, D., Alfarone, C., Baldinelli, G., Boccia, E., Bondatti, F., Casarci, M., Catucci, A. E., Chiappini, M. G., Cioffi, A., Cuzziol, C., De Paolis, P., Della Grotta, B., Daniele, N. D., Di Lullo, L., Di Pietro, G., Di Zazzo, G., Fazzari, L., Feriozzi, S., Ferrazzano, M., Filippini, A., Fini, R., Firmi, G., Flammini, A., Forte, F., Galliani, M., Gamberini, M., Gangeri, F., Grandaliano, Giuseppe, Iamundo, V., Lavini, R., Lonzi, M., Marinelli, R., Marrocco, F., Mene, P., Miglio, L., Morabito, S., Morgia, A., Morosetti, M., Muci, M. L., Nazzaro, L., Nusca, C., Onorato, L., Pace, G., Palumbo, R., Pantano, L., Polito, P., Puliti, M., Rifici, N., Rizzi, E., Rossi, V., Sabry, H., Scabbia, L., Serraiocco, M., Sfregola, P., Simonelli, R., Treglia, A., Umbro, I., Valentini, W., and Grandaliano G. (ORCID:0000-0003-1213-2177)

Abstract

No abstract available

Published
2021

6. Is pizza sutable to type 1 diabetes? A real life identification of best compromise between taste and low glycemic index in patients on insulin pump

Author

Della-Corte, T., primary, Gentile, S., additional, Di Blasi, V., additional, Guarino, G., additional, Corigliano, M., additional, Cozzolino, G., additional, Fasolino, A., additional, Martino, C., additional, Improta, M.R., additional, Oliva, D., additional, Lamberti, C., additional, Vecchiato, A., additional, Vaia, S., additional, Satta, E., additional, Romano, C., additional, Alfarone, C., additional, Strollo, F., additional, Brancato, C., additional, Lambersi, C., additional, Mosca, C., additional, Stile, L.A., additional, Vetrano, A., additional, Visconti, E., additional, Battipaglia, D., additional, Cecco, I., additional, Della Monica, E., additional, Di Capua, M.G., additional, Palmieri, C., additional, Procida, R., additional, and Viesti, F., additional

Published
2020
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7. Lazio dialysis registry: natives vs foreigners

Author

Di Napoli, A, Lapucci, E, Baglio, G, Di Giulio, S, Addessi, M, Alfarone, C, Amoroso, F, Apollinari, E, Baldinelli, G, Baldinelli, M, Barbera, G, Barone, P, Bartolomucci, M, Basili, A, Battista, M, Beraldi, M, Boccia, E, Bruno, F, Buono, A, Canulla, C, Capobianco, L, Caschera, M, Castellano, F, Chamoun, G, Cherubini, C, Chiappini, M, Ciano, G, Costantini, S, Cuzziol, C, Darida, S, Dascal, M, De Bella, E, De Caro, M, De Cicco, C, De Fazio, S, de Virgiliis, G, Della Grotta, F, Della Rovere, F, Di Daniele, N, Di Legge, R, Di Toro Mammarella, R, Dominijanni, S, Esposto, G, Fabozzi, G, Falcone, C, Faraglia, F, Felice, C, Felicioni, R, Feriozzi, S, Ferrari, I, Filippini, A, Fini, R, Firmi, G, Flammini, A, Floccari, F, Forte, F, Galli, D, Galliani, M, Gamberoni, M, Gargiulo, A, Giordano, N, Giustini, A, Grimaldi, R, Hassan, S, Iacono, R, Iamundo, V, Kristuli, L, Laino, M, Leoni, M, Lonzi, M, Lucchetta, F, Maggesano, V, Malaguti, M, Mangeri, M, Marinelli, A, Marinelli, R, Marsili, F, Mauro, L, Mazzaferro, S, Meconizzi, M, Melillo, F, Merigliano, V, Messia, A, Morabito, S, Morosetti, M, Murrone, P, Muzi, L, Nacca, R, Nardone, P, Naticchia, A, Nazzaro, L, Nigro, A, Noce, A, Ordonez, D, Pace, G, Palombo, R, Pantano, L, Panzieri, G, Paone, A, Paparella, M, Pasquarelli, C, Pelosi, M, Petroni, S, Picca, S, Polidori, L, Polito, P, Principe, F, Pulcinelli, G, Puliti, M, Punzo, G, Retico, E, Rifici, N, Riveruzzi, P, Rodriguez, I, Rossi, V, Rossini, B, Santoboni, A, Sfregola, P, Simeoni, P, Simonelli, R, Solazzo, A, Spagnolini, A, Spaziani, M, Splendiani, G, Staffolani, E, Startari, S, Steri, P, Sturniolo, A, Tazza, L, Torre, M, Treglia, A, Triolo, L, Tuderti, F, Tulli, U, Turchetta, L, Valentini, W, Vancini, C, Vastano, S, Vega, A, Ventola, F, Veronese, P, Villani, A, Violi, F, Vitaliano, E, Zanfoni, C, Zazzaro, D, and Zugaro, A

Subjects
Male, Survival Rate, Settore MED/14 - Nefrologia, Italy, Renal Dialysis, Emigrants and Immigrants, Humans, Female, Registries, Middle Aged, Aged
Abstract

An increasing number of foreigners was observed in Italy even among chronic dialysis patients. We compared demographic, clinical, treatment characteristics and survival probability between groups of Italian and foreign patients with chronic dialysis in Lazio.We analysed data from the Lazio Dialysis and Transplantation Registry from 2004 to 2012 (4,076 prevalent chronic dialysis patients in 31-12-2012). Among 7,970 incident patients, we evaluated, by country of birth, survival probability by using Kaplan-Meier method and mortality risk, through multiple Cox regression.We observed an increase of foreigners among chronic dialysis patients in Lazio from 2004 (4.4%) up to 2012 (7.6%, test for trend: p0,001). Compared with Italians, foreign patients were younger (53.816.3 vs. 68.713.6) and more frequently: women (42.7% vs. 37.7%), HbsAg-positive (18.1% vs. 13.9%), not vaccinated if HBV susceptible (26.8% vs. 20.9%), late referral (21.6% vs. 12.9%) and suitable for kidney transplantation (21.7% vs. 9.9%). Foreigners compared with Italians had higher survival probability at 1 year (91.9% vs. 84.7%) and 5 years (74,6% vs. 51,5%) after chronic dialysis has been started. We observed a lower mortality risk (HR=0.71;IC95%:0.58-0.87) among foreign patients even after adjustment for many potential confounding factors. Our findings suggest that health status and treatment of end stage renal disease, including access to kidney transplantation, were similar between groups of Italian and foreign patients in Lazio. Observed differences in patients' characteristics were probably attributable to younger age of foreigners. However, further analyses are needed to fully explain higher survival probability in chronic dialysis among foreigners compared with Italians.

Published
2015

10. Determinants of hospitalization in a cohort of chronic dialysis patients in central Italy

Author

Anteo Di Napoli, Pezzotti, P., Di Lallo, D., Tancioni, V., Papini, P., Guasticchi, G., Addessi, M. A., Ajam, M. F., Alfarone, C., Ancarani, E., Baldinelli, G., Balducci, A., Barbera, V., Barone, P., Battista, M. L., Beraldi, M. P., Biagini, M., Boccia, E., Bravi, M., Brunetti, G., Bucciolini, S., Buono, A., Canulla, F., Caschera, M., Casciani, C. U., Castellano, F., Cavarretta, L., Cerulli, N., Cherubini, C., Chiappini, M. G., Colonnelli, R., Costantini, S., Cuzziol, C., D Adamo, G., Bella, E., Cicco, C., Virgiliis, G., Della Grotta, F., Di Giandomenico, W., Di Giulio, S., Di Legge, R., Di Lullo, L., Di Toro, M. R., Esposto, C., Falcone, C., Felicioni, R., Feliziani, C., Ferrazzoli, F., Filippini, A., Fini, R., Firmi, G., Flammini, A., Forte, F., Franceschelli, L., Galiardi, M. S., Gentile, M., Germani, A., Giordano, F., Giustini, A., Hassan, S., Iamundo, V., Iannacci, R., Iorio, L., Jankovic, L., Luciani, G., Manca, S., Mantella, D., Mangieri, M., Mariano, V., Marin, M., Marinelli, A., Marinelli, R., Massa, P., Mauro, L. M., Mauro, M. M., Meschini, L., Mignozzi, M., Militello, A., Misiti, L., Morabito, S., Morosetti, M., Morricone, A., Moscoloni, M., Murrone, P., Nacca, R., Nazzaro, L., Onorato, L., Pace, G., Palumbo, R., Panzieri, G., Paolozzi, G., Paone, A., Parravano, M., Pasquarelli, C., Pelosi, M., Petroni, S., Poggi, A., Polito, P., and Ponzio, R.

11. Is pizza sutable to type 1 diabetes? A real life identification of best compromise between taste and low glycemic index in patients on insulin pump

Author

T. Della-Corte, S. Gentile, V. Di Blasi, G. Guarino, M. Corigliano, G. Cozzolino, A. Fasolino, C. Martino, M.R. Improta, D. Oliva, C. Lamberti, A. Vecchiato, S. Vaia, E. Satta, C. Romano, C. Alfarone, F. Strollo, C. Brancato, C. Lambersi, C. Mosca, L.A. Stile, A. Vetrano, E. Visconti, D. Battipaglia, I. Cecco, E. Della Monica, M.G. Di Capua, C. Palmieri, R. Procida, F. Viesti, Della-Corte, T., Gentile, S., Di Blasi, V., Guarino, G., Corigliano, M., Cozzolino, G., Fasolino, A., Martino, C., Improta, M. R., Oliva, D., Lamberti, C., Vecchiato, A., Vaia, S., Satta, E., Romano, C., Alfarone, C., Strollo, F., Brancato, C., Lambersi, C., Mosca, C., Stile, L. A., Vetrano, A., Visconti, E., Battipaglia, D., Cecco, I., Della Monica, E., Di Capua, M. G., Palmieri, C., Procida, R., and Viesti, F.

Subjects
Adult, Blood Glucose, Dietary Fiber, Male, 0301 basic medicine, Insulin pump, medicine.medical_specialty, Taste, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Diabete, Low glycemic index, Glucomannan, Gastroenterology, Kamut, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Dietary Carbohydrates, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, In patient, Type 1 diabetes, 030109 nutrition & dietetics, business.industry, food and beverages, nutritional and metabolic diseases, General Medicine, Middle Aged, Whole wheat, medicine.disease, Diabetes Mellitus, Type 1, Treatment Outcome, Glycemic Index, Pizza, Female, business
Abstract

Opposed to whole wheat (WWP), traditional pizza (TP) is loved by patients with type 1 diabetes mellitus (T1DM) despite causing hyperglycemia. 50 well-trained T1DM patients had higher glucose levels after TP than after WWP or mixed flour pizza, which however was tasty, digestible and metabolically appropriate to break diet monotony.

Published
2020

12. HOW to make a mix of low glycemic index flours for a good Neapolitan pizza for patients with diabetes

Author

Carmelo Alfarone, F. Strollo, G. Guarino, Ersilia Satta, Carmine Romano, Salvatore Gentile, T Della Corte, Della Corte, T., Gentile, S., Guarino, G., Satta, E., Romano, C., Alfarone, C., and Strollo, F.

Subjects
Blood Glucose, Dietary Fiber, 0301 basic medicine, Gerontology, Glucose control, Endocrinology, Diabetes and Metabolism, Flour, 030209 endocrinology & metabolism, Low glycemic index, Diabete, Glucomannan, 03 medical and health sciences, Kamut, 0302 clinical medicine, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, medicine, Humans, Triticum, Glycemic, 030109 nutrition & dietetics, business.industry, food and beverages, General Medicine, Postprandial Period, medicine.disease, Whole wheat, Gastrointestinal Tract, Glycemic Index, Pizza, business
Abstract

Background and aims Our recent data document that a low glycemic index (LGI) Neapolitan pizza prepared with a mix of Kamut and whole wheat flours plus Glucomannan, (i) has a lower impact on postprandial hyperglycemic spikes than pizza made of whole wheat flour, (ii) is pleasant and appreciated as traditional one and (iii) does not cause any gastro-intestinal troubles. The aim of our study was to describe the validation process underlying the identification of the right mix of those elements for a LGI pizza preventing gastro-intestinal disturbances. Methods we described all procedures followed to make good products with different combinations of the three components and a series of tests made by four well-experienced professional pasta-making masters, one nutritionist, five diabetologists, one nurse and twenty volunteers with T1DM. Results we could identify the best workable and most suitable flour mix to achieve both pleasant taste and low glycemic impact proving to be efficient in real-life twin paper providing results from diabetic patients. Conclusions this kind of food will certainly help people with diabetes eat pizza without risking any serious deterioration of their own glucose control while fully enjoying socially active life.

Published
2020

13. Why Do So Many People with Type 2 Diabetes Who Take Insulin Have Lipohypertrophy? Fate or Educational Deficiencies?

Author

Gentile S, Guarino G, Della Corte T, Marino G, Satta E, Pasquarella M, Romano C, Alfarone C, Giordano L, Loiacono F, Capece M, Lamberti R, and Strollo F

Abstract

Introduction: Cutaneous lipohypertrophy (LH) is a thickened, "rubbery" lesion in the subcutaneous tissue following multiple injections performed at the same site, i.e., an incorrect injection technique. It is widespread, averaging 47% of insulin patients worldwide, and has severe direct and indirect consequences. Direct consequences consist mainly of poor metabolic control and frequent hypoglycemic events (HYPOs), and indirect ones of markedly increased healthcare costs related to hospital access due to acute events and long-term disease complications. This observation also holds for Italy, despite the National Health System organization expecting every patient with diabetes to undergo a series of visits by different care team members, each performing a specific treatment/education task. Indeed, the recent literature points to poor awareness of LH relevance and metabolic consequences among doctors from general and diabetic hospital wards, with educational deficiencies on correct injection practice in nurses too. The aim was to establish if, to what extent, and by whom they had received training on correct insulin injection techniques, and how many initially received notions had persisted over time., Methods: We investigated the possible causes of such a failure from the point of view of 1160 insulin-requiring subjects with type 2 diabetes (T2DM), reporting for the first time to specialized diabetic structures through a validated questionnaire and, in the same patients, we searched for LH by inspection/palpation according to international guidelines, further confirmed by ultrasound scans. We then analyzed differences in education and injecting behavior between subjects classified as LH+ or LH- depending on the presence or absence of LH lesions., Results: We documented significant educational gaps, with 50% of patients failing to refer to healthcare professionals and relying on their peers with diabetes, thought to be more experienced in 15% of the cases. Seventy-five percent of LH- patients received education from healthcare providers, while 90% of LH+ learned from another patient or could not remember how they knew, and 68% of LH+ versus 52% of LH- (p < 0.01) patients had failed to receive training on injection techniques by healthcare providers. All of this enabled the most disabling features of diabetes from the very beginning of the disease history., Conclusions: This study documents, from the patients' point of view, that educational gaps are significant and that, even in initially trained subjects, education on correct injection techniques has a fleeting effect if not regularly recalled. Therefore, to rehabilitate LH+ patients as soon as possible and prevent LH- patients from inadvertently slipping into the other group, there is an urgent need to educate doctors and nurses repeatedly on the importance of correctly injecting insulin to improve patients' knowledge and skills., (© 2022. The Author(s).)

Published
2023
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14. [A narrative review on arteriovenous fistula for hemodialysis].

Author

Satta E, Romano C, Alfarone C, Raiola I, Scarpati L, Lo Iacono F, Di Maio M, Russo L, Russo D, and Pagliuca MM

Subjects
Humans, Quality of Life, Renal Dialysis methods, Arteriovenous Fistula, Arteriovenous Shunt, Surgical methods, Central Venous Catheters
Abstract

Vascular access is the lifeline for hemodialysis patients. Autologous artero-venous fistula (AVF) is still the most popular vascular access for hemodialysis even if declining during the last decades. Compared to central venous catheters and vascular grafts, AVF is characterized by a lower risk of infection and lower number of hospitalizations, and by a better quality of life, higher dialysis efficiency, and more prolonged life expectancy for patients. Since the year 1966 when the two surgeons Cimino and Brescia had the idea of connecting the forearm vein and artery for chronic dialysis, several data have accumulated on surgical procedures, positioning of AVF (distal vs proximal), time for the first use, monitoring and surveilling. All guidelines suggest that special care should be given by monitoring and surveilling AVF to avoid its failure or fatal closing. Attention should be paid to the patient's vasculature before surgery, through the "maturation" phase and chronic use. Indeed, AVF requires constant and careful care. The crucial role is played by the patient itself in cooperation with devoted clinical staff participated by skilled nurses, nephrologists, surgeons, radiologists, and sonographers. Literature on AVF is evaluated and guidelines suggestions reported as well as the data attained by the Accesso Vascolare per Emodialisi (AVE) project. This project aimed to evaluate the benefits of monitoring and surveilling, operated by a multidisciplinary team on dialysis adequacy, AVF longevity, and patient's mortality., (Copyright by Società Italiana di Nefrologia SIN, Rome,Italy.)

Published
2022

15. Kidney and lung in pathology: mechanisms and clinical implications.

Author

Satta E, Alfarone C, De Maio A, Gentile S, Romano C, Polverino M, and Polverino F

Abstract

There is a close, physiological, relationship between kidney and lung that begin in the fetal age, and is aimed to keep homeostatic balance in the body. From a pathological point of view, the kidneys could be damaged by inflammatory mediators or by immune-mediated factors linked to a primary lung disease or, conversely, it could be the kidney disease that causes lung damage. Non-immunological mechanisms are frequently involved in renal and pulmonary diseases, as observed in chronic conditions. This crosstalk have clinical and therapeutic consequences. This review aims to describe the pulmonary-renal link in physiology and in pathological conditions., (©Copyright: the Author(s).)

Published
2022
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16. Insulin-induced skin lipohypertrophies: A neglected cause of hypoglycemia in dialysed individuals with diabetes.

Author

Gentile S, Satta E, Strollo F, Guarino G, Romano C, Della Corte T, and Alfarone C

Subjects
Diabetes Mellitus drug therapy, Humans, Injections, Intradermal, Kidney Failure, Chronic, Hypoglycemia chemically induced, Hypoglycemic Agents adverse effects, Insulin adverse effects, Lipoma chemically induced, Renal Dialysis
Abstract

Background: Diabetes mellitus (DM) is the leading cause of end-stage renal disease and 50% of dialysis patients are insulin-treated., Aim: to search for unexplained hypoglycemia (HYPO)., Methods: identify a possible cause of HYPO due to altered insulin absorption., Results: insulin injected into subcutaneous lipo-hypertrophy (LH) nodules leads to unpredictable HYPOS., Conclusion: looking for LH systematically and training patients to the best injection technique are new challenges for nephrologists to reduce HYPO and emergency hospitalization rates, thus sparing healthcare resources and improving the quality of life of insulin-treated dialysis patients., Competing Interests: Declaration of competing interest None of the authors has conflicts of interest to declare., (Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.)

Published
2021
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17. Insulin-Induced Skin Lipohypertrophy in Type 2 Diabetes: a Multicenter Regional Survey in Southern Italy.

Author

Gentile S, Guarino G, Corte TD, Marino G, Fusco A, Corigliano G, Colarusso S, Piscopo M, Improta MR, Corigliano M, MartedÌ E, Oliva D, Russo V, Simonetti R, Satta E, Romano C, Alfarone C, Vetrano A, Martino C, Lamberti C, Vecchiato A, Cozzolino G, Brancario C, and Strollo F

Abstract

Introduction: Lipohypertrophies (LHs) due to incorrect insulin injection techniques have been described in the literature for decades. Their rate averages 38%, but this is still controversial because of the vast range reported by different publications, most of which fail to describe the selected detection protocol and therefore are not entirely reliable. We still need to identify the real LH rate, and only consistently using a standardized method in a large cohort of insulin-treated (IT) patients make this possible., Methods: Our group performed thorough clinical skin examinations on patients suffering from type 2 diabetes mellitus (T2DM): 1247 IT T2DM outpatients were examined according to a standardized protocol, previously published elsewhere, as well as an ultrasound scan of the same skin areas to assess the degree of concordance between the two methods and to evaluate the demographic, clinical, and behavioral risk factors (RF) as well as metabolic consequences of identified LHs., Results: The concordance between the two methods was 99%. Identified risk factors for LHs were needle reuse, failure to rotate injection sites, and ice-cold insulin injections. High HbA1c values, wide glycemic variability, and longstanding proneness to hypoglycemia with a high rate of ongoing hypoglycemic events proved to be significantly associated with LHs, too; the same applied to cardiovascular and renal complications as well as to living alone and being retired., Conclusions: Based on a strict well-structured methodology, our data confirmed what has already been reported in the literature on factors leading to, or associated with, LHs and, for the first time in adults, indicated cryotrauma from ice-cold insulin injections and specific social conditions as factors facilitating LH occurrence. HCPs should therefore plan a yearly clinical examination of all injection sites to improve patient quality of life through better glucose control and a reduced rate of hypoglycemic events., Trial Registration: Trial registration no. 127-11.01.2019, approved by the Scientific and Ethics Committee of Campania University "Luigi Vanvitelli," Naples, Italy.

Published
2020
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18. Effects of carnitine administration in patients with chronic renal failure undergoing periodic dialysis, evaluated by computerized electromyography.

Author

Rocchi L, Feola I, Calvani M, D'Iddio S, Alfarone C, and Frascarelli M

Subjects
Adult, Computers, Electromyography, Evoked Potentials drug effects, Female, Humans, Kidney Failure, Chronic therapy, Male, Middle Aged, Muscle Contraction drug effects, Muscles physiopathology, Renal Dialysis, Uremia metabolism, Uremia physiopathology, Carnitine pharmacology, Kidney Failure, Chronic physiopathology, Muscles drug effects
Abstract

The effects of chronic administration of L-carnitine were evaluated by EMG analysis in 20 uraemic patients undergoing periodical haemodialysis (mean duration of dialysis 34.7 months). No important changes in motor conduction velocity or distal latency of the external popliteal nerve were found after the treatment, while a reduction in the number of polyphasic muscle action potentials was observed. After carnitine administration, an increase of total EMG power was noted and the spectral array showed a progressive shift towards lower frequencies in 8 patients who had shown higher values. These results suggest that carnitine has a prevalent "myotrophic" effect.

Published
1986

19. [Kaposi's sarcoma and kidney transplant].

Author

Terzoli E, Alfarone C, Cardamone I, Izzo F, Lucatelli S, Olivadese A, and Ranuzzi M

Subjects
Adult, Humans, Male, Sarcoma, Kaposi pathology, Skin Neoplasms pathology, Immunosuppressive Agents adverse effects, Kidney Transplantation, Sarcoma, Kaposi chemically induced, Skin Neoplasms chemically induced
Abstract

Ex novo Kaposi's Sarcoma 4 months after renal transplantation in a young patient is described. Progression of the tumoral lesions has been observed during combined immunosuppressive treatment with Prednisone, Azathioprine and Cyclosporin. Stopping Azathioprine and Cyclosporin as well as reducing Prednisone prevented new lesions and made the preexistent skin lesions less extensive. Clinical case, possible pathogenesis and therapeutic strategies are discussed.

Published
1989

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