13 results on '"Alexiadis, George"'
Search Results
2. Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology
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Bjornsdottir, Gyda, Stefánsdóttir, Lilja, Thorleifsson, Gudmar, Sulem, Patrick, Norland, Kristjan, Ferkingstad, Egil, Oddsson, Asmundur, Zink, Florian, Lund, Sigrun H., Nawaz, Muhammad S., Bragi Walters, G., Skuladottir, Astros Th., Gudjonsson, Sigurjon A., Einarsson, Gudmundur, Halldorsson, Gisli H., Bjarnadottir, Valgerdur, Sveinbjornsson, Gardar, Helgadottir, Anna, Styrkársdóttir, Unnur, Gudmundsson, Larus J., Pedersen, Ole B., Hansen, Thomas Folkmann, Werge, Thomas, Banasik, Karina, Troelsen, Anders, Skou, Soren T., Thørner, Lise Wegner, Erikstrup, Christian, Nielsen, Kaspar Rene, Mikkelsen, Susan, Andersen, Steffen, Brunak, Søren, Burgdorf, Kristoffer, Hjalgrim, Henrik, Jemec, Gregor, Jennum, Poul, Johansson, Per Ingemar, Nielsen, Kasper Rene, Nyegaard, Mette, Bruun, Mie Topholm, Pedersen, Ole Birger, Dinh, Khoa Manh, Sørensen, Erik, Ostrowski, Sisse R., Johansson, Pär Ingemar, Gudbjartsson, Daniel F., Stefansson, Hreinn, Þorsteinsdóttir, Unnur, Larsen, Margit Anita Hørup, Didriksen, Maria, Sækmose, Susanne, Zeggini, Eleftheria, Hatzikotoulas, Konstantinos, Southam, Lorraine, Gilly, Arthur, Barysenka, Andrei, van Meurs, Joyce B. J., Boer, Cindy G., Uitterlinden, André G., Jonsson, Helgi, Ingvarsson, Thorvaldur, Esko, Tõnu, Mägi, Reedik, Teder-Laving, Maris, Ikegawa, Shiro, Terao, Chikashi, Takuwa, Hiroshi, Meulenbelt, Ingrid, Coutinho de Almeida, Rodrigo, Kloppenburg, Margreet, Tuerlings, Margo, Slagboom, P. Eline, Nelissen, Rob R. G. H. H., Valdes, Ana M., Mangino, Massimo, Tsezou, Aspasia, Zengini, Eleni, Alexiadis, George, Babis, George C., Cheah, Kathryn S. E., Wu, Tian T., Samartzis, Dino, Cheung, Jason Pui Yin, Sham, Pak Chung, Kraft, Peter, Kang, Jae Hee, Hveem, Kristian, Zwart, John-Anker, Luetge, Almut, Skogholt, Anne Heidi, Johnsen, Marianne B., Thomas, Laurent F., Winsvold, Bendik, Gabrielsen, Maiken E., Lee, Ming Ta Michael, Zhang, Yanfei, Lietman, Steven A., Shivakumar, Manu, Smith, George Davey, Tobias, Jonathan H., Hartley, April, Gaunt, Tom R., Zheng, Jie, Wilkinson, J. Mark, Steinberg, Julia, Morris, Andrew P., Jonsdottir, Ingileif, Bjornsson, Aron, Olafsson, Ingvar H., Ulfarsson, Elfar, Blondal, Josep, Vikingsson, Arnor, Brunak, Soren, Ullum, Henrik, Thorsteinsdottir, Unnur, Thorgeirsson, Thorgeir E., Stefansson, Kari, Consortium, DBDS Genetic, Consortium, GO, and Internal Medicine
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Science ,General Physics and Astronomy ,Intervertebral Disc Degeneration ,Intervertebral Disc/metabolism ,Bone and Bones/metabolism ,Bone and Bones ,General Biochemistry, Genetics and Molecular Biology ,health services administration ,Humans ,Sodium Sulfate Cotransporter/genetics ,Intervertebral Disc ,3' Untranslated Regions ,health care economics and organizations ,Sodium Sulfate Cotransporter ,Symporters/genetics ,Multidisciplinary ,Symporters ,Sulfates ,General Chemistry ,equipment and supplies ,Intervertebral Disc Degeneration/genetics ,Intervertebral Disc Displacement/genetics ,Sulfates/metabolism ,population characteristics ,human activities ,Intervertebral Disc Displacement ,Genome-Wide Association Study - Abstract
Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (ORIDD = 0.92, P = 1.6 × 10−39; ORdorsalgia = 0.92, P = 7.2 × 10−15) is with a 3’UTR variant (rs1871452-T) in CHST3, encoding a sulfotransferase enzyme expressed in intervertebral discs. The largest effects on IDD are conferred by rare (MAF = 0.07 − 0.32%) loss-of-function (LoF) variants in SLC13A1, encoding a sodium-sulfate co-transporter (LoF burden OR = 1.44, P = 3.1 × 10−11); variants that also associate with reduced serum sulfate. Genes implicated by this study are involved in cartilage and bone biology, as well as neurological and inflammatory processes.
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- 2022
3. Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index
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Hartley, April, Sanderson, Eleanor, Granell, Raquel, Paternoster, Lavinia, Zheng, Jie, Smith, George Davey, Southam, Lorraine, Hatzikotoulas, Konstantinos, Boer, Cindy G., Van Meurs, Joyce, Zeggini, Eleftheria, Gregson, Celia L., Tobias, Jon H., Stefánsdóttir, Lilja, Zhang, Yanfei, De Almeida, Rodrigo Coutinho, Wu, Tian T., Teder-Laving, Maris, Skogholt, Anne Heidi, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Barysenka, Andrei, Bjornsdottir, Gyda, Gabrielsen, Maiken E., Gilly, Arthur, Ingvarsson, Thorvaldur, Johnsen, Marianne B., Jonsson, Helgi, Kloppenburg, Margreet G., Luetge, Almut, Mägi, Reedik, Mangino, Massimo, Nelissen, Rob R.G.H.H., Shivakumar, Manu, Steinberg, Julia, Takuwa, Hiroshi, Thomas, Laurent, Tuerlings, Margo, Babis, George, Cheung, Jason Pui Yin, Samartzis, Dino, Lietman, Steve A., Slagboom, P. Eline, Stefansson, Kari, Uitterlinden, André G., Winsvold, Bendik, Zwart, John Anker, Sham, Pak Chung, Thorleifsson, Gudmar, Gaunt, Tom R., Morris, Andrew P., Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Ikegawa, Shiro, Hveem, Kristian, Esko, Tõnu, Wilkinson, J. Mark, Meulenbelt, Ingrid, Michael Lee, Ming Ta, Styrkársdóttir, Unnur, and Internal Medicine
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Oncology ,musculoskeletal diseases ,medicine.medical_specialty ,UK Biobank ,Epidemiology ,body mass index ,Osteoarthritis ,Polymorphism, Single Nucleotide ,Genetic correlation ,Body Mass Index ,Mendelian Randomization ,Uk Biobank ,Bone Mineral Density ,Bone Density ,Internal medicine ,Mendelian randomization ,medicine ,Humans ,Allele ,Risk factor ,Bone mineral ,business.industry ,General Medicine ,Mendelian Randomization Analysis ,Osteoarthritis, Knee ,medicine.disease ,Causality ,Observational study ,business ,bone mineral density ,Body mass index ,Genome-Wide Association Study - Abstract
Objectives Observational analyses suggest that high bone mineral density (BMD) is a risk factor for osteoarthritis (OA); it is unclear whether this represents a causal effect or shared aetiology and whether these relationships are body mass index (BMI)-independent. We performed bidirectional Mendelian randomization (MR) to uncover the causal pathways between BMD, BMI and OA. Methods One-sample (1S)MR estimates were generated by two-stage least-squares regression. Unweighted allele scores instrumented each exposure. Two-sample (2S)MR estimates were generated using inverse-variance weighted random-effects meta-analysis. Multivariable MR (MVMR), including BMD and BMI instruments in the same model, determined the BMI-independent causal pathway from BMD to OA. Latent causal variable (LCV) analysis, using weight-adjusted femoral neck (FN)–BMD and hip/knee OA summary statistics, determined whether genetic correlation explained the causal effect of BMD on OA. Results 1SMR provided strong evidence for a causal effect of BMD estimated from heel ultrasound (eBMD) on hip and knee OA {odds ratio [OR]hip = 1.28 [95% confidence interval (CI) = 1.05, 1.57], p = 0.02, ORknee = 1.40 [95% CI = 1.20, 1.63], p = 3 × 10–5, OR per standard deviation [SD] increase}. 2SMR effect sizes were consistent in direction. Results suggested that the causal pathways between eBMD and OA were bidirectional (βhip = 1.10 [95% CI = 0.36, 1.84], p = 0.003, βknee = 4.16 [95% CI = 2.74, 5.57], p = 8 × 10–9, β = SD increase per doubling in risk). MVMR identified a BMI-independent causal pathway between eBMD and hip/knee OA. LCV suggested that genetic correlation (i.e. shared genetic aetiology) did not fully explain the causal effects of BMD on hip/knee OA. Conclusions These results provide evidence for a BMI-independent causal effect of eBMD on OA. Despite evidence of bidirectional effects, the effect of BMD on OA did not appear to be fully explained by shared genetic aetiology, suggesting a direct action of bone on joint deterioration.
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- 2022
4. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
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Boer, Cindy G., Hatzikotoulas, Konstantinos, Southam, Lorraine, Stefánsdóttir, Lilja, Zhang, Yanfei, Coutinho de Almeida, Rodrigo, Wu, Tian T., Zheng, Jie, Hartley, April, Teder-Laving, Maris, Skogholt, Anne Heidi, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Barysenka, Andrei, Bjornsdottir, Gyda, Gabrielsen, Maiken E., Gilly, Arthur, Ingvarsson, Thorvaldur, Johnsen, Marianne B., Jonsson, Helgi, Kloppenburg, Margreet, Luetge, Almut, Lund, Sigrun H., Mägi, Reedik, Mangino, Massimo, Nelissen, Rob R.G.H.H., Shivakumar, Manu, Steinberg, Julia, Takuwa, Hiroshi, Thomas, Laurent F., Tuerlings, Margo, Babis, George C., Cheung, Jason Pui Yin, Kang, Jae Hee, Kraft, Peter, Lietman, Steven A., Samartzis, Dino, Slagboom, P. Eline, Stefansson, Kari, Thorsteinsdottir, Unnur, Tobias, Jonathan H., Uitterlinden, André G., Winsvold, Bendik, Zwart, John-Anker, Davey Smith, George, Sham, Pak Chung, Thorleifsson, Gudmar, Gaunt, Tom R., Morris, Andrew P., Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Ikegawa, Shiro, Hveem, Kristian, Esko, Tõnu, Wilkinson, J. Mark, Meulenbelt, Ingrid, Lee, Ming Ta Michael, van Meurs, Joyce B.J., Styrkársdóttir, Unnur, and Zeggini, Eleftheria
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- 2021
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5. Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients
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Lambropoulou, Maria, Papadopoulos, Nikolaos, Tripsianis, Grigoris, Alexiadis, George, Pagonopoulou, Olga, Kiziridou, Anastasia, Liberis, Vassilios, Kakolyris, Stylianos, and Chatzaki, Ekaterini
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- 2010
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6. Cytoplasmic Expression of c-erb-B2 in Endometrial Carcinomas
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Lambropoulou, Maria, Stefanou, Dimitrios, Alexiadis, George, Tamiolakis, Demetrio, Tripsianis, Grigorios, Chatzaki, Ekaterini, Vandoros, Gerasimos P., Kiziridou, Anastasia, Papadopoulou, Evropi, and Papadopoulos, Nikolas
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- 2007
- Full Text
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7. Latissimus Dorsi Transfer in Posterior Irreparable Rotator Cuff Tears
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Anastasopoulos, Panagiotis P., primary, Alexiadis, George, additional, Spyridonos, Sarantis, additional, and Fandridis, Emmanouil, additional
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- 2017
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8. Jaw bone metastases: four cases
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Alexiadis, George, Jivanakis, Theodoros, Lambropoulou, Maria, Papadopoulos, Nikolaos, Tamiolakis, Dimitrios, Thomaidis, Vasilios, Tsamis, Ioannis, and Venizelos, Ioannis
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stomatognathic diseases - Abstract
Objective: Metastatic tumors make up approximately one percent of all oral malignancies. Such tumors may present in the jawbones and oral soft tissues. The commonest oral site is the mandible. Patients and methods: This is a retrospective study of four cases of metastatic tumors of the jaws seen at theOral-Maxillofacial Department, General University Hospital of Alexandroupolis, Thrace, Greece from 1989 to 2005, representing 1 % of all histologically confirmed malignant tumors at the hospital. Results: Two cases originated from the thyroid gland, one was from the esophagus, and one from the liver. Three metastases occurred in the mandible and one in the maxilla. The oral symptoms were similar to odontogenic infections or to benign neoplasms. Conclusions: In view of the resemblance in the presentation of metastases and other tumors affecting the jaws, a high index of clinical suspicion is advocated to ensure early, multidisciplinary care of hosts.
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- 2007
9. Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients
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Lambropoulou, Maria, primary, Papadopoulos, Nikolaos, additional, Tripsianis, Grigoris, additional, Alexiadis, George, additional, Pagonopoulou, Olga, additional, Kiziridou, Anastasia, additional, Liberis, Vassilios, additional, Kakolyris, Stylianos, additional, and Chatzaki, Ekaterini, additional
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- 2009
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10. Does Neoplastic Cholecystokinin Expression Reflect the Embryonal Pattern of the Protein? A Study in Human Pancreas
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Tamiolakis, Demetrio, primary, Venizelos, Ioannis, additional, Simopoulos, Constantine, additional, Lambropoulou, Maria, additional, Kotini, Athanasia, additional, Jivannakis, Theodoros, additional, Alexiadis, George, additional, Boglou, Panagiotis, additional, and Papadopoulos, Nikolas, additional
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- 2004
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11. Jaw bone metastases: four cases.
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Tamiolakis D, Tsamis I, Thomaidis V, Lambropoulou M, Alexiadis G, Venizelos I, Jivanakis T, and Papadopoulos N
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- Adenocarcinoma diagnosis, Aged, Diagnosis, Differential, Esophageal Neoplasms pathology, Female, Humans, Liver Neoplasms pathology, Male, Mandibular Neoplasms diagnosis, Maxillary Neoplasms diagnosis, Middle Aged, Retrospective Studies, Thyroid Neoplasms pathology, Adenocarcinoma secondary, Mandibular Neoplasms secondary, Maxillary Neoplasms secondary
- Abstract
Objective: Metastatic tumors make up approximately one percent of all oral malignancies. Such tumors may present in the jaw bones and oral soft tissues. The commonest oral site is the mandible., Patients and Methods: This is a retrospective study of four cases of metastatic tumors of the jaws seen at the Oral-Maxillofacial Department, General University Hospital of Alexandroupolis, Thrace, Greece from 1989 to 2005, representing 1% of all histologically confirmed malignant tumors at the hospital., Results: Two cases originated from the thyroid gland, one was from the esophagus, and one from the liver. Three metastases occurred in the mandible and one in the maxilla. The oral symptoms were similar to odontogenic infections or to benign neoplasms., Conclusions: In view of the resemblance in the presentation of metastases and other tumors affecting the jaws, a high index of clinical suspicion is advocated to ensure early, multidisciplinary care of hosts.
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- 2007
12. Papillary thyroid carcinoma metastasis most probably due to fine needle aspiration biopsy. A case report.
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Tamiolakis D, Antoniou C, Venizelos J, Lambropoulou M, Alexiadis G, Ekonomou C, Tsiminikakis N, Alifieris E, Papadopoulos N, Konstandinidis T, and Kouskoukis C
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- Female, Humans, Middle Aged, Muscle Neoplasms etiology, Skin Neoplasms etiology, Biopsy, Fine-Needle adverse effects, Carcinoma, Papillary secondary, Muscle Neoplasms secondary, Neoplasm Seeding, Skin Neoplasms secondary, Thyroid Neoplasms pathology
- Abstract
Implantation of cancer cells from needle biopsy has been reported in a wide range of malignancies. Fine needle aspiration biopsy has become an accepted method for assessment of thyroid nodules. Local reappearance of thyroid cancer from needle track dissemination is a rare complication of thyroid aspiration. A 45-year-old female developed local recurrence of papillary thyroid carcinoma four years after aspiration biopsy and thyroidectomy. Metastatic deposits appeared in the skin and the sternocleidomastoid muscle. The linear array and the site of metastases implied that seeding most probably resulted from the needle biopsy.
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- 2006
13. Brooke-Spiegler syndrome with parotid gland involvement.
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Kakagia D, Alexiadis G, Kiziridou A, and Lambropoulou M
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- Aged, Carcinoma, Adenoid Cystic complications, Carcinoma, Adenoid Cystic pathology, Diagnosis, Differential, Female, Forehead pathology, Humans, Neoplastic Syndromes, Hereditary complications, Neoplastic Syndromes, Hereditary pathology, Parotid Neoplasms complications, Scalp pathology, Skin Neoplasms complications, Skin Neoplasms pathology, Syndrome, Carcinoma, Adenoid Cystic diagnosis, Neoplastic Syndromes, Hereditary diagnosis, Parotid Neoplasms diagnosis, Skin Neoplasms diagnosis
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Salivary gland involvement in Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease, is known though not frequent. A case of familial cylindromatosis with parotid gland adenoma is herein reported. A 67-year-old lady presented with multiple scalp nodules and papular coalescent lesions over the nasolabial folds and the forehead. The clinical examination also revealed a left preauricular lump. Multiple biopsies of the scalp lesions and the nasolabial papules revealed cylindromas and trichoepitheliomas respectively. CT scan and FNA of the preauricular lump were suggestive of parotid gland adenoma. The patient underwent excision of the scalp cylindromas and total left parotidectomy. There is no evidence of recurrence after 4 years. The association of BSS with salivary gland tumours, emphasizes the necessity of thorough salivary gland examination in all patients with skin lesions. Knowledge of the genetic background of BSS allows for genetic counseling of patients.
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- 2004
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