1. Pancreatic neuroendocrine microadenomatosis presenting as a functional VIPoma
- Author
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Jamie K Murphy, Daniel F Klink, Alexei A Krainev, Gabie K B Ong, Jonathan M. Saxe, and Viney K. Mathavan
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Vasoactive intestinal peptide ,Metabolic acidosis ,Case Report ,medicine.disease ,Pancreaticoduodenectomy ,Gastroenterology ,Hypokalemia ,Work-up ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,030211 gastroenterology & hepatology ,Surgery ,medicine.symptom ,business ,Pancreas ,Multiple endocrine neoplasia ,VIPoma - Abstract
Pancreatic microadenomas are benign tumors of neuroendocrine origin less than 5 mm in size. Whereas most microadenomas are non-functional; a few rare functional pancreatic microadenomas have been described in the setting of multiple endocrine neoplasia type one (MEN-1). In this report, we describe a unique case of multiple functional microadenomas of the pancreatic head in a patient who presented with persistent secretory diarrhea, refractory hypokalemia, metabolic acidosis and elevated plasma vasoactive intestinal peptide (VIP) levels. Following extensive serologic, radiographic and endoscopic work up, our patient underwent open pancreaticoduodenectomy with subsequent resolution of diarrheal symptoms and electrolyte abnormalities on postoperative follow up.
- Published
- 2019