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Resumo Introdução A mortalidade por tuberculose é um indicador sensível às desigualdades em saúde, considerando-se que o risco para sua ocorrência está relacionado à vulnerabilidade dos territórios. Objetivo Investigar se as variações espaciais dos determinantes sociais afetam as mortes por tuberculose em um município da região amazônica. Método Estudo ecológico com medidas múltiplas de análise, composto por óbitos por tuberculose como causa básica em Manaus, Amazonas, Brasil, notificados no Sistema de Informação sobre Mortalidade (2006-2015). Nas análises, foram calculadas as taxas bruta e padronizada, e usado o Índice de Moran para verificar a autocorrelação espacial da mortalidade e, posteriormente, foi aplicada a regressão geograficamente ponderada para aferir a relação da desigualdade com as mortes por tuberculose. Resultados Foram identificados 731 óbitos pela doença. A distribuição da mortalidade ocorreu de forma heterogênea, sendo que as altas taxas de óbito por tuberculose estavam em áreas mais socialmente vulneráveis. Foram confirmadas a autocorrelação e a dependência espacial. O modelo final apresentou as variáveis indicadoras de iniquidades (baixa renda, pobreza e escolaridade), mostrando relação destas com a mortalidade. Conclusão Ficou evidente que os determinantes sociais no espaço urbano influenciam a mortalidade por tuberculose na região. Portanto, avançar em políticas públicas para corrigir as iniquidades em saúde pode influenciar positivamente esse cenário. Abstract Background Mortality from tuberculosis is a sensitive indicator of health inequalities, given that the risk for its occurrence is related to the vulnerability of the territories. Objective To investigate whether the spatial variations of social determinants affect deaths from tuberculosis in a municipality in the Amazon region. Method Ecological study with multiple measures of analysis. The study was composed of deaths from tuberculosis as a basic cause in Manaus, Amazonas, Brazil, reported in the Brazilian Mortality Information System (2006-2015). In the analyzes, the crude and standardized rate was calculated, Moran Index was used to verify the spatial autocorrelation of mortality, and subsequently, the geographically weighted regression was applied to assess the inequality relationship of deaths from tuberculosis. Results 731 deaths from the disease were identified. The distribution of mortality was heterogeneous, with high rates of death from tuberculosis in more socially vulnerable areas. The autocorrelation and spatial dependence was confirmed. The final model presented variables that indicate inequities: low income, poverty and education, showing their relationship with mortality. Conclusion It was evident that social determinants in the urban space influence mortality from tuberculosis in the region. Therefore, advancing public policies to correct health inequities can positively impact this scenario.

Introduction: Prisons are high-risk settings for drug-resistant tuberculosis because the prevalence of the tuberculosis (TB) is much higher than in the general population. This study to investigated the factors associated with drug-resistant tuberculosis in prisons in the state of São Paulo, Brazil. Methodology: Retrospective cohort of drug-resistant TB cases for incarcerated people in São Paulo state, reported in the Tuberculosis Patient Control System between 2006 and 2016. To analyze the factors associated with drug-resistant TB, the backward method (likelihood ratio) was used, determining the adjusted odds ratio and respective 95%CI coefficients. Multiple models were proposed to adjust for potential confusion and interaction. The best fit model was selected based on the lowest Akaike information criterion coefficient. Results: In total, 473 drug-resistant tuberculosis cases were reported in the prison population of Sāo Paulo state, the majority were male. The cases that presented negative results for sputum smear and sputum culture had, respectively, an aOR=0.6 and aOR=0.16 for drug-resistant tuberculosis in relation to the cases with positive results. The cases where the patient had AIDS and reported alcoholism, respectively, an aOR=1.47 and aOR=1.60 for drug-resistant TB. Individuals with a background treatment history for TB presented a stronger association with drug-resistant tuberculosis, aOR=35.08. Conclusions: Sputum spear, sputum culture, chest X-ray, AIDS, alcoholism and background treatment history for TB were factors associated with resistance to antituberculosis drugs among prisoners. This is useful for the implementation of disease control measures related to the detection and monitoring of cases in the prison system.

Background Multidrug-resistant tuberculosis (MDR-TB) is a serious phenomenon on a global scale that can worsen with the COVID-19 pandemic. The study aimed to understand the perceptions of health professionals about MDR-TB, their strategies to ensure adherence to treatment and their challenges in the context of the COVID-19 pandemic in a priority municipality for disease control. Methods We conducted a qualitative study and recruited 14 health providers (four doctors, three nurses, three nursing technicians, three nursing assistants and a social worker) working in a city in the state of São Paulo, Brazil. Remote semi-structured interviews were conducted with the participants. For data analysis, the thematic content analysis technique was applied according to the study’s theoretical framework. Results The study revealed the causes of MDR-TB are associated with poverty, vulnerability, and social risk. A pre-judgement from the providers was observed, namely, all patients do not adhere due their resistance and association with drug abuse or alcoholism. The study also observed difficulty among health providers in helping patients reconstruct and reframe their life projects under a care perspective, which would strengthen adherence. Other issues that weakened adherence were the cuts in social protection and the benefits really necessary to the patients and a challenge for the providers manage that. The participants revealed that their actions were impacted by the pandemic and insecurity and fear manifested by patients after acquiring COVID-19. For alleviating this, medical appointments by telephone, delivery of medicine in the homes of patients and visits by health professionals once per week were provided. Conclusion The study advances knowledge by highlighting the challenges faced by the health system with the adherence of patients with MDR-TB in a context aggravated by the pandemic. An improvement in DOT is really necessary to help the patients reframe their lives without prejudices, face their fears and insecurity, recover their self-esteem and motivate in concluding their treatment.

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) itself is a serious phenomenon on a global scale that can worsen with the COVID-19 pandemic. The study aimed to understand the perception of health professionals about multidrug-resistant tuberculosis, their strategies to ensure adherence to treatment and the challenges in the context of the COVID-19 pandemic, in a priority municipality for disease control in the state of São Paulo, Brazil. METHODS: We conducted a qualitative study and recruited fourteen health professionals, four doctors, three nurses, three nursing technicians, three nursing assistants and a social worker, working in the Ribeirão Preto health system. Remote semi-structured interviews were conducted with these professionals. For data analysis, Thematic Content Analysis was applied according to the theoretical framework defined for the study. RESULTS: The findings showed the relationship between poverty, inequality and MDR-TB. Concerning the COVID-19 pandemic, reports from professionals show an interference in the monitoring of patients. As for social protection and the benefits that covered the patients, they were cut. Professionals also reported concerns about obtaining COVID-19 and adopting strategies to ensure adherence, as well as reinforcements of the DOTS strategy. CONCLUSION: The study advances in knowledge by highlighting the challenges faced by the health system for the adherence of MDR-TB patients in a context aggravated by Pandemic. The strategies defined by these health professionals have somehow guaranteed the achievement of equity and avoided the catastrophic encounter between TB-MDR and COVID-19.

This study aimed to analyze the discourses of patients who were diagnosed with multidrug-resistant tuberculosis, the perception of why they acquired this health condition and barriers to seeking care in a priority city in Brazil during the COVID-19 pandemic. This was an exploratory qualitative study, which used the theoretical-methodological framework of the Discourse Analysis of French matrix, guided by the Consolidated Criteria for Reporting Qualitative Research. The study was conducted in Ribeirão Preto, São Paulo, Brazil. Seven participants were interviewed who were undergoing treatment at the time of the interview. The analysis of the participants’ discourses allowed the emergence of four discursive blocks: (1) impact of the social determinants in the development of multidrug-resistant tuberculosis, (2) barriers to seeking care and difficulties accessing health services, (3) perceptions of the side effects and their impact on multidrug-resistant tuberculosis treatment, and (4) tuberculosis and COVID-19: a necessary dialogue. Through discursive formations, these revealed the determinants of multidrug-resistant tuberculosis. Considering the complexity involved in the dynamics of multidrug-resistant tuberculosis, advancing in terms of equity in health, that is, in reducing unjust differences, is a challenge for public policies, especially at the current moment in Brazil, which is of accentuated economic, political and social crisis. The importance of psychosocial stressors and the lack of social support should also be highlighted as intermediary determinants of health. The study has also shown the situation of COVID-19, which consists of an important barrier for patients seeking care. Many patients reported fear, insecurity and worry with regard to returning to medical appointments, which might contribute to the worsening of tuberculosis in the scenario under study.

BACKGROUNDAccording to the World Health Organization, there are approximately one million cases of tuberculosis in the world's child population, and the disease is responsible for 130.000 deaths per year, which makes tuberculosis one of the top 10 causes of death in children in the world. The objective of the study was to identify areas of risk for the appearance of tuberculosis in children and their association with social inequalities in a municipality in southeastern Brazil.METHODSEcological study conducted in Ribeirão Preto, Brazil. To identify areas of spatial risk for tuberculosis in children, we use the technique of spatial scanning statistics. To analyze the association of cases of childhood tuberculosis with social vulnerability, the Social Vulnerability Index of São Paulo was used and four explanatory statistical models were listed.RESULTS96 cases of childhood tuberculosis were reported, of which 90 were geocoded. A risk area was identified in the municipality, where children under 15 years old have 3.14 times more risk of contracting tuberculosis than outside this area. Of the models tested, the Zero-Inflated Poisson probability distribution was the one that best suited the nature of the variables. The variables identified as risk factors were: number of private and collective households; Proportion of children aged 0 to 5 in the population; Proportion of households without per capita income; Proportion of private households with monthly nominal incomes of up to 1/4 minimum wages. The variables identified as possible protection factors, there was a proportion of women responsible for the household under 30 and an average income of women responsible for the household.CONCLUSIONThe study showed areas of risk for the occurrence of tuberculosis in children. Although the study was conducted in a city with satisfactory social indicators, income distribution is quite uneven, as the findings reveal. The study is in line with the End TB Strategy and the 2030 agenda, which aims to support strategic actions and, therefore, save the lives of children through the systematic, intensified and comprehensive search of children with tuberculosis respiratory symptoms in the community.

ObjectiveTo identify the risk areas of deaths due to unspecified pneumonia and tuberculosis (TB) in children, and to identify if there is a relationship between these events with higher TB incidence and social determinants.MethodsEcological study carried out in Brazil. All cases of TB or unspecified pneumonia deaths in children under 5 years of age reported between 2006 and 2016 were included and collected through Department of Informatics of the Unified Health System (Brazil’s electronic database). The Spatial Scan Statistics was used to identify areas at higher risk of dying from this event. The spatial association was verified through the Getis-Ord techniques. The Bivariate Moran Global Index was used to verify the spatial autocorrelation between the two events. To identify the association of TB and pneumonia deaths with endemic areas of pulmonary TB and social determinants, four explanatory statistical models were identified.ResultsA total of 21 391 cases of pneumonia and 238 cases of TB were identified. Spatial scanning analysis enabled the detection of four clusters of risk for TB (relative risk, RR, between 3.30 and 18.18) and 22 clusters for pneumonia (RR between 1.38 and 5.24). The spatial association of the events was confirmed (z-score 3.74 and 64.34) and spatial autocorrelation between events (Moran Index:0.031 (p=0.001)). The zero-inflated negative binomial distribution was chosen, and an association for both events was identified with the TB incidence rate (OR 5.3, 95% CI 2.85 to 9.84; OR 6.63, 95% CI 5.62 to 7.81), with the Gini Index (OR 1.78, 95% CI 1.12 to 2.82; OR 4.22, 95% CI 3.63 to4.92). Primary care coverage showed an inverse association for both events (OR 0.10, 95% CI 0.67 to 0.17; OR 0.18, 95% CI 0.15 to 0.21) for pneumonia). Finally, a family that benefited from the Bolsa Família Programme had an inverse association for deaths from pneumonia (OR 0.81, 95% CI 0.52 to 1.25).ConclusionsThe results do not just contribute to reduce mortality in children, but mainly contribute to prevent premature deaths through identification of critical areas in Brazil, which is crucial to qualify health surveillance services.

This study’s objective was to estimate the temporal trends of leprosy according to sex and age groups, as well as to estimate and predict the progression of the disease in a hyperendemic city located in the northeast of Brazil. This ecological time-series study was conducted in Imperatriz, Maranhão, Brazil. Leprosy cases diagnosed between 2006 and 2016 were included. Detection rates stratified by sex and age groups were estimated. The study of temporal trends was accomplished using the Seasonal-Trend Decomposition method and temporal modeling of detection rates using linear seasonal autoregressive integrated moving average model according to Box and Jenkins method. Trend forecasts were performed for the 2017–2020 period. A total of 3,212 cases of leprosy were identified, the average incidence among men aged between 30 and 59 years old was 201.55/100,000 inhabitants and among women in the same age group was 135.28/100,000 inhabitants. Detection rates in total and by sex presented a downward trend, though rates stratified according to sex and age presented a growing trend among men aged less than 15 years old and among women aged 60 years old or over. The final models selected in the time-series analysis show the forecasts of total detection rates and rates for men and women presented a downward trend for the 2017–2020 period. Even though the forecasts show a downward trend in Imperatriz, the city is unlikely to meet a significant decrease of the disease burden by 2020.

Objetivou-se identificar fatores relacionados, classificar a tendência temporal e identificar áreas com associação espacial do abandono de tratamento para tuberculose em Ribeirão Preto, São Paulo. Estudo ecológico; população composta pelos casos notificados entre 2006 a 2017. Realizou-se o teste qui-quadrado para identificar fatores relacionados. Para a tendência temporal, utilizou-se o método de Prais-Winsten para classificar a tendência temporal do evento e calculada sua porcentagem de variação anual. Para verificar associação espacial, utilizaram-se as técnicas G e Gi*. Foram notificados 146 casos de abandono do tratamento da doença no período; como fatores de risco foi identificado pessoas sem escolaridade, retratamentos pós-abandono e falência prévia; como proteção casos novos identificados pela busca ativa, não ter coinfecção Tuberculose-HIV e não fazer uso de álcool ou drogas. A taxa de abandono apresenta tendência crescente (APC=1,6%; IC95% 0.02–3.48). O estudo evidencia o aumento do abandono de tratamento, contrariando as políticas direcionadas pelo End TB Strategy. Descritores: Tuberculose; Cooperação e Adesão ao Tratamento; Saúde Pública; Análise Espacial.

Introduction: Tuberculosis (TB) is the primary cause of death among infectious diseases affecting groups in extreme poverty. Social improvements could reverse this situation in Brazil. This study aims to demonstrate the spatial relationship between social development (SD) and TB mortality in Natal, a city in northeastern Brazil. Methodology: Ecological study. The study population comprised TB deaths recorded in the Mortality Information System between 2008 and 2014. The units of analysis were 59 human development units (HDUs). Raw and smoothed mortality rates were calculated using the global empirical Bayes method. Primary components analysis was used to develop the SD indicators. An association between TB mortality and SD was verified using multiple linear regression analysis. Spatial autocorrelation was verified using models with global spatial effects. Analyses were performed using Statistica version 12.0, ArcGIS version 10.2, Statistical Package for the Social Sciences version 20.0, and OpenGeoDa 1.0.1. The significance level was established at 5% (p < 0.05). Results: The TB mortality rate with non-random spatial distribution ranged between 0.52 and 8.90 per 100,000 inhabitants. The spatial lag model was chosen because it presented the highest log-likelihood value, lowest AIC, and highest R2. A negative association was found between TB mortality and SD (R2 = 0.207; p = 0.03). Conclusions: The results show a negative association between TB mortality and the high SD indicator. This study can support decision-making in terms of collective projects within public health in order to link the health field to other sectors, aiming for social well-being and human development.

Objective: to analyze scientific production on the evaluation of Primary Health Care services in the control of tuberculosis. Method: this is a bibliographical study, including an integrative review, which included complete articles available in the LILACS, CINAHL, SCOPUS, Web of Science and MEDLINE databases, "published in Brazil between January 2013 and September 2017. The results were presented in the form of figures. Results: 12 articles were selected and classified in two thematic categories: "Evaluation of services from the perspective of health professionals" and "Evaluation of services from the perspective of users". Conclusion: the synthesis of the studies confirms the weaknesses, suggesting the complementary training to the professionals, besides the rescue of the expanded concept of health, mainly, in relation to the family and the community, contributing to the base of management conduits for the improvement of health interventions. Descriptors: Primary health care; Tuberculosis; Research on Health Services; Nursing; Brazil; Basic Health Services. RESUMO Objetivo: analisar producoes cientificas sobre a avaliacao dos servicos da Atencao Primaria a Saude no controle da tuberculose. Metodo: trata-se de estudo bibliografico, tipo revisao integrativa, que incluiu artigos completos disponibilizados nas Bases de Dados LILACS, CINAHL, SCOPUS, Web of Science e MEDLINE, publicados no Brasil entre janeiro de 2013 a setembro de 2017. Apresentaram-se os resultados em forma de figuras. Resultados: selecionaram-se e classificaram-se 12 artigos em duas categorias tematicas: “Avaliacao dos servicos na perspectiva dos profissionais de saude” e “Avaliacao dos servicos na perspectiva dos usuarios”. Conclusao: ratificam-se, pela sintese dos estudos, as fragilidades, sugerindo a formacao complementar aos profissionais, alem do resgate do conceito expandido de saude, principalmente, com relacao a familia e a comunidade, contribuindo para o embasamento de condutas de gestao para a melhoria das intervencoes em saude. Descritores : Atencao Primaria a Saude; Tuberculose; Pesquisa sobre Servicos de Saude; Enfermagem; Brasil; Servicos Basicos de Saude. RESUMEN Objetivo: analizar producciones cientificas sobre la evaluacion de los servicios de la Atencion Primaria a la Salud en el control de la tuberculosis. Metodo: se trata de un estudio bibliografico, tipo revision integrativa, que incluyo articulos completos disponibles en las Bases de Datos LILACS, CINAHL, SCOPUS, Web of Science y MEDLINE, publicados en Brasil entre enero de 2013 a septiembre de 2017. Se presentaron los resultados en forma de figuras. Resultados: se seleccionaron y se clasificaron 12 articulos en dos categorias tematicas: "Evaluacion de los servicios en la perspectiva de los profesionales de salud" y "Evaluacion de los servicios en la perspectiva de los usuarios". Conclusion: se ratifican, por la sintesis de los estudios, las fragilidades, sugiriendo la formacion complementaria a los profesionales, ademas del rescate del concepto ampliado de salud, principalmente, con relacion a la familia y a la comunidad, contribuyendo para el basamento de conductas de gestion para la mejora de las intervenciones en salud. Descritores : Atencion Primaria a la Salud; Tuberculosis; Investigacion sobre Servicios de Salud; Enfermeira; Brasil; Servicios Basicos de Salud.

BackgroundTo evaluate the effectiveness of a rapid molecular test for the detection of tuberculosis (TB) and to predict the rates of disease in a municipality of Brazil where TB is endemic.MethodsAn ecological study was carried out in Ribeirão Preto-SP on a population of TB cases notified between 2006 and 2017. Monthly TB incidence rates and the average monthly percentage change (AMPC) were calculated. In order to identify changes in the series, the breakpoint technique was performed; the rates were modelled and predictions of the incidence of TB until 2025 were made.ResultsAMPC showed a fall of 0.69% per month in TB and human immunodeficiency virus (TB-HIV) co-infection, a fall of 0.01% per month in general and lung TB and a fall of 0.33% per month in extrapulmonary TB. With the breakpoint technique, general and pulmonary TB changed in structure in late 2007, and extrapulmonary TB and TB-HIV co-infection changed in structure after 2014, which is considered the cut-off point. The IMA(3) models were adjusted for general and pulmonary TB and TB-HIV co-infection, and the AR(5) models for extrapulmonary TB, and predictions were performed.ConclusionsThe rapid molecular test for TB is the method currently recommended by the WHO for the diagnosis of the disease and its main advantage is to provide faster, more accurate results and to already check for drug resistance. It is necessary that professionals encourage the use of this technology in order to optimize the diagnosis so that the treatment begins as quickly as possible and in an effective way. Only by uniting professionals from all areas with health policies aimed at early case identification and rapid treatment initiation it is possible to break the chain of TB transmission so that its rates decrease and the goals proposed by the WHO are achieved.

Objetivo: evaluar el impacto de la prueba rapida molecular GeneXpert® MTB/RIF en la deteccion de tuberculosis, analizar la tendencia temporal del evento e identificar territorios vulnerables en un municipio brasileno. Metodo: estudio ecologico realizado en Ribeirao Preto, Sao Paulo, Brasil, municipio considerado prioritario en el control de la tuberculosis por el elevado numero de casos. Se utilizo el metodo de Prais-Winsten para clasificar la tendencia temporal y la tecnica de Series de Tiempo Interrumpidas para identificar cambios en la incidencia de la enfermedad. Se aplico un analisis de intensidad de Kernel para identificar areas vulnerables. Resultados: la tendencia temporal de la tuberculosis disminuyo un 18,1%/ano y un 6,9%/ano en los menores de 15 anos. La incidencia de tuberculosis disminuyo un 6,67%/ano en el Distrito Norte y aumento un 17,5%/ano en el Distrito Este. La tuberculosis resistente, despues de la implementacion de la Prueba Molecular Rapida, aumento un 0,6% anual. Los Distritos Sur y Oeste presentaron una mayor densidad de casos, con un rango de 45 a 79 casos de tuberculosis por kilometros cuadrados (km2). Conclusion: aunque la tuberculosis resistente no representa un problema en el escenario, el estudio mostro un aumento en la incidencia, lo que genera una senal de alerta. El uso del analisis espacial permitio identificar areas prioritarias, para que puedan llevarse a cabo acciones de vigilancia en salud.