1. Normal brain aging and Alzheimer's disease are associated with lower cerebral pH: an in vivo histidine 1 H-MR spectroscopy study
- Author
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Yang Liu, Epameinondas Lyros, Andreas Ragoschke-Schumm, Wolfgang Reith, Panagiotis Kostopoulos, Stefania Kalampokini, Alexandra Sehr, Martin Backens, Martin Lesmeister, Klaus Fassbender, and Yann Decker
- Subjects
0301 basic medicine ,In vivo magnetic resonance spectroscopy ,Aging ,medicine.medical_specialty ,Creatine ,Phosphocreatine ,White matter ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Centrum semiovale ,medicine ,Dementia ,Vascular dementia ,business.industry ,General Neuroscience ,medicine.disease ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Developmental Biology ,Frontotemporal dementia - Abstract
It is unclear whether alterations in cerebral pH underlie Alzheimer's disease (AD) and other dementias. We performed proton spectroscopy after oral administration of histidine in healthy young and elderly persons and in patients with mild cognitive impairment and dementia (total N = 147). We measured cerebral tissue pH and ratios of common brain metabolites in relation to phosphocreatine and creatine (Cr) in spectra acquired from the hippocampus, the white matter (WM) of the centrum semiovale, and the cerebellum. Hippocampal pH was inversely associated with age in healthy participants but did not differ between patients and controls. WM pH was low in AD and, to a lesser extent, mild cognitive impairment but not in frontotemporal dementia spectrum disorders and pure vascular dementia. Furthermore, WM pH provided incremental diagnostic value in addition to N-acetylaspartate to Cr ratio. Our study suggests that in vivo assessment of pH may be a useful marker for the differentiation between AD and other types of dementia.
- Published
- 2020
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