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Weekly didactic conference in emergency medicine education has traditionally united residents and faculty for learning and fostered community within the residency program The global pandemic Coronavirus Disease-19 (COVID-19) has fueled a rapid transition to remote learning that has disrupted the typical in-person format To maintain ACGME1 educational experiences and requirements for residents in a safe manner, many residencies have moved to videoconferencing platforms such as Zoom?, Teams?, and WebEX ?

Introducción: este artículo es producto de la investigación titulada “Uso de clar en fase inversa para la determinación del contenido de formaldehído libre en esmaltes de uñas”, desarrollada en el 2015 en el Centro de Innovación Aplicada en Tecnologías Competitivas (ciatec). Metodología: se determinó el contenido de formaldehído libre en 50 muestras de esmaltes para uñas de diversas marcas comercializadas en León, Guanajuato, México. El tratamiento de muestras se realizó de acuerdo con el método iso 17226-1:2003, con ligeras modificaciones: se pesaron 2±0,1 g de esmaltes en matraces Erlenmeyer de 100 ml, se adicionaron 40 ml de dodecil sulfonato de sodio al 0,1 %. Las muestras fueron entonces tapadas y se dejaron en baño María a 40 °c con agitación constante durante 60 minutos; posteriormente se filtraron y se tomaron alícuotas de cada muestra para su derivatización con 2,4-dinitrofenilhidracina al 0,3 % durante 60 minutos. La determinación analítica se realizó por clar en fase inversa con detección por arreglo de diodos. Resultados: se obtuvo como resultado que todas las muestras de esmaltes para uñas analizadas estuvieron por debajo del límite normativo de contenido de formaldehído libre en cosméticos de 0,2 %. Conclusiones: se obtuvo información de relevancia toxicológica sobre el formaldehído libre en los esmaltes de uñas, además de comprobar la versatilidad y robustez del método de prueba.

We present an interesting case where a patient is presented with a droopy left eyelid (as part of Horner syndrome) and Cushingoid features which were a result of a Pancoast tumour (apical lung tumour in superior pulmonary sulcus) involving the left lung. This tumour was secreting ectopic adrenocorticotropic hormone (ACTH), a paraneoplastic endocrine phenomenon, which resulted in Cushing syndrome symptomatology. Though most ectopic ACTH-producing lung cancers are either small cell or carcinoid tumours, this was in fact a large cell neuroendocrine cancer (LCNEC). Patient underwent surgical resection and adjuvant/neoadjuvant chemotherapy with radiation; however, he succumbed to LCNEC given aggressive nature of the disease.

Brain injury during the last trimester to the first 1-4 years in humans is now thought to trigger an array of intellectual and emotional problems later in life, including disorders such as schizophrenia. In adult schizophrenic brains, there is a specific loss of neurons that co-express glutamic acid decarboxylase-parvalbumin (GAD67-PV). Loss of this phenotype is thought to occur in mature animals previously exposed to N-methyl-D: -aspartate receptor (NMDAR) antagonists during late gestation or at postnatal day 7 (P7). However, in similarly treated animals, we have previously shown that GAD67 and PV are unaltered in the first 24 h. To more precisely define when changes in these markers first occur, we exposed rat pups (P7 or P6-P10) to the NMDAR antagonist MK801 and at P11 co-stained brain sections for GAD67 or PV. In the cingulate cortex, we found evidence for a reduction in PV (GAD67 levels were very low to undetectable). In contrast, in the somatosensory cortex, we found that expression of GAD67 was reduced, but PV remained stable. Further, repeated but not single doses of MK801 were necessary to see such changes. Thus, depending on the region, NMDAR antagonism appears to influence expression of PV or GAD67, but not both. These observations could not have been predicted by previous studies and raise important questions as to how the GAD67-PV phenotype is lost once animals reach maturity. More importantly, such differential effects may be of great clinical importance, given that cognitive deficits are seen in children exposed to anesthetics that act by blocking the NMDAR.

N-methyl-D-aspartate receptor blockade promotes apoptosis at postnatal day 7 (P7) and is linked to loss of glutamic acid decarboxylase 67 (GAD67) expression in older animals. To more fully appreciate this relationship we must first understand how GAD67 is regulated postnatally. Thus, the brains of P7, P14 and P21 rats were examined for expression of GAD67 protein and we found that levels of this GABAergic marker increased steadily with age, such that by P21 there was as much as a 6-fold increase compared to P7 animals and a 1.5- to 2-fold increase compared to P14 animals, depending on the region sampled. At P7, GAD67 was almost exclusively detected in puncta, with very few cell bodies displaying this marker. In contrast, at P14 and especially P21, both puncta and cell bodies were robustly labeled. Our data indicate that adult-like expression of GAD67 emerges quite late in the postnatal period.