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Diabetic nephropathy (DN) or Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes mellitus (DM). DN is observed in approximately 20–40% of diabetic patients. DN is also an important risk factor for DM patient’s death. Nowadays, DN has become the leading cause of chronic renal failure (CRF) in most countries without effective therapeutic methods. Recently, the renoprotective effects mediated by vitamin D have been evidenced. Currently available evidence showed that vitamin D is effective in reducing proteinuria in DN patients. A recent meta-analysis demonstrated the therapeutic effect of vitamin D, on urinary albumin excretion, in DN patients. This review summarized the multiple roles of vitamin D in mechanism of renopretective effect of vitamin D to explore much more and effective therapeutic methods for DN.

It remains controversial, whether vitamin D reduces urinary albumin excretion in patients with diabetic nephropathy (DN). This metaanalysis was designed to evaluate the therapeutic effect of vitamin D, on urinary albumin excretion, in DN patients. Electronic databases, including PubMed, Embase, Web of Science, and Cochrane library were searched for randomized controlled trials (RCTs), regarding the effect of vitamin D on urinary albumin excretion in DN patients. The study selection and data extraction were conducted by two reviewers independently, and statistical analysis was performed using RevMan software, version 5.2. A total of nine RCTs including 1547 subjects were qualified. There were 815 participants in the study group and 732 in the control group. The fixed-effect model was used to analyze urinary albumin creatinine ratio (UACR) and urinary albumin excretion ratio (UAER), and the pooled standard mean difference (SMD) was -0.24 (95% CI: -0.39 to -0.09), P = .002, and -0.57 (95% CI: -0.71 to -0.43), P.00001; respectively. These findings indicated that vitamin D-treated patients had a statistically significant reduction in UACR and UAER. High-quality RCTs are still required. DOI: 10.52547/ijkd.7107.