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6,662 results on '"Alexander, John A."'

1. Predictors of bleeding and thrombotic events among patients admitted to the hospital with COVID-19 and elevated D-dimer: insights from the ACTION randomized clinical trial

Author

de Barros e Silva, Pedro Gabriel Melo, Furtado, Remo H. M., de Alcântara Chaud, Mariana Silveira, Macedo, Ariane Vieira Scarlatelli, Bronhara, Bruna, Damiani, Lucas Petri, Barbosa, Lilian Mazza, Suiama, Mayra Akimi, Ramacciotti, Eduardo, de Aquino Martins, Priscilla, de Oliveira, Aryadne Lyrio, Nunes, Vinicius Santana, Ritt, Luiz Eduardo Fonteles, Rocha, Ana Thereza, Tramujas, Lucas, Santos, Sueli V., Diaz, Dario Rafael Abregu, Viana, Lorena Souza, Melro, Lívia Maria Garcia, Figueiredo, Estêvão Lanna, Neuenschwander, Fernando Carvalho, Dracoulakis, Marianna Deway Andrade, Lima, Rodolfo Godinho Souza Dourado, de Souza Dantas, Vicente Cés, Fernandes, Anne Cristine Silva, Gebara, Otávio Celso Eluf, Hernandes, Mauro Esteves, Queiroz, Diego Aparecido Rios, Veiga, Viviane C., Canesin, Manoel Fernandes, de Faria, Leonardo Meira, Feitosa-Filho, Gilson Soares, Gazzana, Marcelo Basso, Liporace, Idelzuíta Leandro, de Oliveira Twardowsky, Aline, Maia, Lilia Nigro, Machado, Flávia Ribeiro, de Matos Soeiro, Alexandre, Conceição-Souza, Germano Emílio, Armaganijan, Luciana, Guimarães, Patrícia O., Rosa, Regis G., Azevedo, Luciano C. P., Alexander, John H., Avezum, Alvaro, Berwanger, Otávio, Cavalcanti, Alexandre B., and Lopes, Renato D.

Published
2024
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5. The rise of study skills at Strathclyde (and our part in its downfall): a bildungsroman

Author

Alexander John Cuthbert and Derek Keenan

Subjects
spaces, places, Learning Development, Theory and practice of education, LB5-3640
Abstract

In 2012, three members of staff were recruited by the University of Strathclyde to sit in a room and talk to students. That was the whole of the plan. That is not how this story ends. The talking was supposed to ‘help’ students to do things ‘right’. That is not what we spoke about. That year, the student-facing part of the Centre for Academic Practice and Learning Enhancement (CAPLE) established in 1987, which at its height consisted of six permanent academics with varied research interests within the, then emergent, field of Learning Development (LD), was replaced by a generic Study Skills Service, staffed by LD practitioners with a considerable collective experience and who shared a vision that was more critical and looked to a more authentically (learning) developmental approach (Asher, 2024). In so doing, the university had created a service model which we would spend the next nine years dismantling (or, to be more accurate, redeveloping). What follows is our story. The story of how the Learner Development Service (LDS) came into being, and how the spaces and places we have inhabited (both hostile and hospitable) have shaped our practices (Gravett et al., 2023) and how, in June 2022, we took up residency in a dedicated LDS Centre designed by us for us. To date, we have occupied three physical locations and been positioned under three different university services. These spaces and places have defined what we could do but they have also informed the design of our current physical, virtual and conceptual environment, as this paper details. This session highlighted the need for Learning Development practitioner resilience and perseverance in difficult circumstances. It foregrounds the usefulness of initiating, developing, and nurturing productive and mutually rewarding professional relationships with academic departments, course leaders and individual academics in order to advance the growth of Learning Development provision in institutions.

Published
2024
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7. RACE: A Real-Time Architecture for Cognitive State Estimation, Development Overview and Study in Progress

Author

Beauchemin, Noémie, Karran, Alexander John, Boasen, Jared, Tadson, Bella, Charland, Patrick, Courtemanche, François, Sénécal, Sylvain, Léger, Pierre-Majorique, Spagnoletti, Paolo, Series Editor, De Marco, Marco, Series Editor, Pouloudi, Nancy, Series Editor, Te'eni, Dov, Series Editor, vom Brocke, Jan, Series Editor, Winter, Robert, Series Editor, Baskerville, Richard, Series Editor, Za, Stefano, Series Editor, Braccini, Alessio Maria, Series Editor, Davis, Fred D., editor, Riedl, René, editor, Brocke, Jan vom, editor, Léger, Pierre-Majorique, editor, Randolph, Adriane B., editor, and Müller-Putz, Gernot R., editor

Published
2024
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8. The Dynamics of Collaborative Decision-Making with Intelligent Systems

Author

Öz, Burak, Karran, Alexander-John, Beringer, Joerg, Coursaris, Constantinos K., Léger, Pierre-Majorique, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Stephanidis, Constantine, editor, Antona, Margherita, editor, Ntoa, Stavroula, editor, and Salvendy, Gavriel, editor

Published
2024
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9. End-To-End Intelligent Automation Loops

Author

Beringer, Joerg, Karran, Alexander-John, Coursaris, Constantinos K., Leger, Pierre-Majorique, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Stephanidis, Constantine, editor, Antona, Margherita, editor, Ntoa, Stavroula, editor, and Salvendy, Gavriel, editor

Published
2024
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11. Restrictive Versus Liberal Transfusion in Patients With Type 1 or Type 2 Myocardial Infarction: A Prespecified Analysis of the MINT Trial

Author

DeFilippis, Andrew P., Abbott, J. Dawn, Herbert, Brandon M., Bertolet, Marnie H., Chaitman, Bernard R., White, Harvey D., Goldsweig, Andrew M., Polonsky, Tamar S., Gupta, Rajesh, Alsweiler, Caroline, Silvain, Johanne, de Barros e Silva, Pedro G.M., Hillis, Graham S., Daneault, Benoit, Tessalee, Meechai, Menegus, Mark A., Rao, Sunil V., Lopes, Renato D., Hébert, Paul C., Alexander, John H., Brooks, Maria M., Carson, Jeffrey L., and Goodman, Shaun G.

Published
2024
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12. Abstract 4145154: A Pilot Study of Post-Discharge Atrial Fibrillation Using a Novel Mobile Electrocardiography Monitoring Device

Author

Iribarne, Alexander, Patel, Nirav, DʼAlessandro, David, DiMaio, John, Bhavnani, Sanjeev, Badhwar, Vinay, Sengupta, Partho, Johnson, Linda, Gajewska-Dendek, Elzbieta, Kramer, Robert, Moquete, Ellen, Hupf, Jonathan, Duncan, Prezley, Mihelis, Efstathia, Borger, Michael, Muir, Andrew, Starnes, Vaughn, Edegran, Albin, Fenton, Kathleen, Taddei-Peters, Wendy, Moskowitz, Alan, OGara, Patrick, Gelijns, Annetine, Alexander, John, Gillinov, A, and Bagiella, Emilia

Published
2024
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15. Dissecting the role of ZAK-beta in skeletal muscle using zebrafish as a model organism

Author

Russell, Alexander John, Pownall, Mary Elizabeth, and Blanco, Gonzalo

Abstract

Congenital myopathies are a group of inherited, heterogenous, rare muscle diseases, associated with progressive muscle wasting, chronic disability and a reduced quality of life. Inheritance of mutations in ZAK, a gene encoding a MAP triple kinase, has been identified as a novel cause of congenital myopathy in humans. This thesis utilises zebrafish to model the impacts of absence of ZAK on skeletal muscle, with investigations ranging from development studies to the analysis of the aging process of muscle in adult zebrafish. In contrast to other vertebrates, where the two isoforms are achieved through differential splicing of a single gene (to produce ZAK-alpha and ZAK-beta), in zebrafish the two isoforms exist as different genes on separate chromosomes, simplifying efforts to target each isoform. ZAK-beta is shown to be the isoform expressed in zebrafish skeletal muscle, and CRISPR-Cas9 gene editing was used to create mutations in each ZAK isoform and raise lines of zebrafish lacking either individual or both isoforms. Sequencing of the mRNA transcript and qRT-PCR confirmed mutations to each isoform result in a premature stop codon, and that there was a significant reduction in transcript levels. Breeding the ZAK-beta-/- line into transgenic reporter lines allowed the assessment of the structure of developing skeletal muscle, and the immune response of neutrophils following wounding in larval zebrafish, using confocal imaging. Individual muscle fibre area was significantly reduced in ZAK-beta-/- embryos at two and five days of development, compared to wild type, potentially indicating growth defects in the skeletal muscle. Aged ZAK-beta-/- zebrafish (35-months-old) show significantly decreased swimming capabilities, as well as abnormalities in the ultrastructure absent in age-matched wild type controls, suggesting a potential accelerated aging process in skeletal muscle with loss of ZAK. Thus, ZAK-beta signalling may represent a promising target for developing novel therapies for the treatment of sarcopenia.

Published
2023

18. ApoA-I Infusions and Burden of Ischemic Events After Acute Myocardial Infarction: Insights From the AEGIS-II Trial

Author

Gibson, C. Michael, Chi, Gerald, Duffy, Danielle, Bahit, M. Cecilia, White, Harvey, Korjian, Serge, Alexander, John H., Lincoff, A. Michael, Anschuetz, Gaya, Girgis, Ihab G., Nicolau, Jose C., Lopes, Renato D., Cornel, Jan H., Bainey, Kevin R., Libby, Peter, Sacks, Frank M., Ridker, Paul M, Goodman, Shaun G., Mahaffey, Kenneth W., Nicholls, Stephen J., Pocock, Stuart J., Mehran, Roxana, and Harrington, Robert A.

Published
2024
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22. Effect of Apixaban on Clinical Outcomes in Outpatients With COVID-19: The APOLLO Randomized Clinical Trial

Author

de Barros e Silva, Pedro Gabriel Melo, Macedo, Ariane Vieira Scarlatelli, Bronhara, Bruna, Damiani, Lucas Petri, Mazza Barbosa, Lilian, Lopes, Nathália Rodrigues, Suiama, Mayra Akimi, Antunes, Murillo O., Gonçalves, Mariana Raquel, Gebara, Otávio Celso Eluf, de Aquino Martins, Priscilla, Ribeiro, Mariana Galvão, de Moura Xavier de Moraes, João Batista, Jr, Aguiar, Valéria Cristina Resende, Cavalcanti, Alexandre B., Rosa, Regis G., Berwanger, Otavio, Veiga, Viviane C., Azevedo, Luciano C.P., Ramacciotti, Eduardo, Granger, Christopher B., Alexander, John H., Avezum, Alvaro, and Lopes, Renato D.

Published
2024
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23. Search for dark photons using a multilayer dielectric haloscope equipped with a single-photon avalanche diode

Author

Manenti, Laura, Mishra, Umang, Bruno, Gianmarco, Di Giovanni, Adriano, Millar, Alexander John, Morå, Knut Dundas, Pasricha, Renu, Roberts, Henry, Oikonomou, Panos, Sarnoff, Isaac, Weston, James, and Arneodo, Francesco

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report on the results of the search for dark photons with mass around 1.5$\,\rm eV/c^2$ using a multilayer dielectric haloscope equipped with an affordable and commercially available photosensor. The multilayer stack, which enables the conversion of dark photons (DP) to Standard Model photons, is made of 23 bilayers of alternating SiO$_2$ and Si$_3$N$_4$ thin films with linearly increasing thicknesses through the stack (a configuration known as a "chirped stack"). The thicknesses have been chosen according to an optimisation algorithm in order to maximise the DP-photon conversion in the energy region where the photosensor sensitivity peaks. This prototype experiment, baptised MuDHI (Multilayer Dielectric Haloscope Investigation) by the authors of this paper, has been designed, developed and run at the Astroparticle Laboratory of New York University Abu Dhabi, which marks the first time a dark matter experiment has been operated in the Middle East. No significant signal excess is observed, and the method of maximum log-likelihood is used to set exclusion limits at $90\%$ confidence level on the kinetic mixing coupling constant between dark photons and ordinary photons.

Published
2021
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25. Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome

Author

Barr, Cathy L., Batterson, James R., Berlin, Cheston, Budman, Cathy L., Coppola, Giovanni, Cox, Nancy J., Darrow, Sabrina, Dion, Yves, Freimer, Nelson B., Grados, Marco A., Greenberg, Erica, Hirschtritt, Matthew E., Huang, Alden Y., Illmann, Cornelia, King, Robert A., Kurlan, Roger, Leckman, James F., Lyon, Gholson J., Malaty, Irene A., McMahon, William M., Neale, Benjamin M., Okun, Michael S., Osiecki, Lisa, Robertson, Mary M., Rouleau, Guy A., Sandor, Paul, Singer, Harvey S., Smit, Jan H., Sul, Jae Hoon, Androutsos, Christos, Basha, Entela, Farkas, Luca, Fichna, Jakub, Janik, Piotr, Kapisyzi, Mira, Karagiannidis, Iordanis, Koumoula, Anastasia, Nagy, Peter, Puchala, Joanna, Szejko, Natalia, Szymanska, Urszula, Tsironi, Vaia, Apter, Alan, Ball, Juliane, Bodmer, Benjamin, Bognar, Emese, Buse, Judith, Vela, Marta Correa, Fremer, Carolin, Garcia-Delgar, Blanca, Gulisano, Mariangela, Hagen, Annelieke, Hagstrøm, Julie, Madruga-Garrido, Marcos, Pellico, Alessandra, Ruhrman, Daphna, Schnell, Jaana, Silvestri, Paola Rosaria, Skov, Liselotte, Steinberg, Tamar, Gloor, Friederike Tagwerker, Turner, Victoria L., Weidinger, Elif, Alexander, John, Aranyi, Tamas, Buisman, Wim R., Buitelaar, Jan K., Driessen, Nicole, Drineas, Petros, Fan, Siyan, Forde, Natalie J., Gerasch, Sarah, van den Heuvel, Odile A., Jespersgaard, Cathrine, Kanaan, Ahmad S., Möller, Harald E., Nawaz, Muhammad S., Nespoli, Ester, Pagliaroli, Luca, Poelmans, Geert, Pouwels, Petra J.W., Rizzo, Francesca, Veltman, Dick J., van der Werf, Ysbrand D., Widomska, Joanna, Zilhäo, Nuno R., Brown, Lawrence W., Cheon, Keun-Ah, Coffey, Barbara J., Fernandez, Thomas V., Gilbert, Donald L., Hong, Hyun Ju, Ibanez-Gomez, Laura, Kim, Eun-Joo, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett L., Maras, Athanasios, Murphy, Tara L., Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, State, Matthew W., Visscher, Frank, Wang, Sheng, Zinner, Samuel H., Tsetsos, Fotis, Topaloudi, Apostolia, Jain, Pritesh, Yang, Zhiyu, Yu, Dongmei, Kolovos, Petros, Tumer, Zeynep, Rizzo, Renata, Hartmann, Andreas, Depienne, Christel, Worbe, Yulia, Müller-Vahl, Kirsten R., Cath, Danielle C., Boomsma, Dorret I., Wolanczyk, Tomasz, Zekanowski, Cezary, Barta, Csaba, Nemoda, Zsofia, Tarnok, Zsanett, Padmanabhuni, Shanmukha S., Buxbaum, Joseph D., Grice, Dorothy, Glennon, Jeffrey, Stefansson, Hreinn, Hengerer, Bastian, Yannaki, Evangelia, Stamatoyannopoulos, John A., Benaroya-Milshtein, Noa, Cardona, Francesco, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Mir, Pablo, Morer, Astrid, Mueller, Norbert, Munchau, Alexander, Plessen, Kerstin J., Porcelli, Cesare, Roessner, Veit, Walitza, Susanne, Schrag, Anette, Martino, Davide, Tischfield, Jay A., Heiman, Gary A., Willsey, A. Jeremy, Dietrich, Andrea, Davis, Lea K., Crowley, James J., Mathews, Carol A., Scharf, Jeremiah M., Georgitsi, Marianthi, Hoekstra, Pieter J., and Paschou, Peristera

Published
2024
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26. A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

Author

Mannion, Jonathan, Gifford, Valentina, Bellenie, Benjamin, Fernando, Winnie, Ramos Garcia, Laura, Wilson, Rebecca, John, Sidonie Wicky, Udainiya, Savita, Patin, Emmanuel C., Tiu, Crescens, Smith, Angel, Goicoechea, Maria, Craxton, Andrew, Moraes de Vasconcelos, Nathalia, Guppy, Naomi, Cheung, Kwai-Ming J., Cundy, Nicholas J., Pierrat, Olivier, Brennan, Alfie, Roumeliotis, Theodoros I., Benstead-Hume, Graeme, Alexander, John, Muirhead, Gareth, Layzell, Scott, Lyu, Wenxin, Roulstone, Victoria, Allen, Mark, Baldock, Holly, Legrand, Arnaud, Gabel, Florian, Serrano-Aparicio, Natalia, Starling, Chris, Guo, Hongyan, Upton, Jason, Gyrd-Hansen, Mads, MacFarlane, Marion, Seddon, Benedict, Raynaud, Florence, Roxanis, Ioannis, Harrington, Kevin, Haider, Syed, Choudhary, Jyoti S., Hoelder, Swen, Tenev, Tencho, and Meier, Pascal

Published
2024
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27. Identification and characterisation of FIP37-4 suppressor mutants in Arabidopsis thaliana

Author

Bridgen, Alexander John

Subjects
QK457 Spermatophyta. Phanerogams, QP501 Animal biochemistry
Abstract

Post-transcriptional and co-transcriptional RNA modifications play essential roles in controlling mRNA fate. The most abundant internal mRNA modification in eukaryotic cells is N6-methyladenosine (m6A) which has been shown to be critical for development in many eukaryotes and plays an important role influencing biological processes through its regulatory effects on RNA metabolism and translation. m6A is a dynamic modification with deposition of m6A on mRNA being catalysed by the methyltransferase "writer" complex, removed by demethylases "erasers" and recognised by m6A binding proteins known as "readers" which play specific regulatory roles. The Arabidopsis thaliana core m6A writer complex comprises of MTA (METTL3), MTB (METTL14), FIP37 (WTAP) VIRILIZER (VIRMA), HAKAI, HIZ1 and HIZ2 (likely homologue of ZC3H13). How m6A methylation machinery is regulated and knowledge of components mediating its various functions is still far from fully understood: especially in plants. To further understand how m6A methylation is regulated and identify novel factors involved, a forward genetic suppressor screen was performed on hypomorphic FIP37 T-DNA insertion mutant fip37-4. A number of fip37-4 suppressor mutants were identified which exhibited wild-type (WT) like phenotypes. Further characterisation of the recessive suppressor mutant P2-04 demonstrated increased global m6A methylation to 57% WT-level, partial loss of fip37-4 developmental defects including hyperbranched trichomes, delayed flowering, reduced root growth, insensitivity to auxin and RT-qPCR analysis showed three-fold increase in functional FIP37 transcript. Bulked segregant analysis combined with comprehensive screening of backcrossed populations identified P2-04 causal mutation to likely be a missense mutation within the fourth KH domain of KH domain RNA binding protein AtKH26 (AtKH26R472Q). Confocal microscopy revealed AtKH26 to be nuclear localised and complementation of P2-04 with AtKH26-GFP transgene rescued fip37-4 phenotype suggesting AtKH26R472Q is the causal mutation. Transcriptomic analysis on P2-04 highlighted restored WT expression of genes differentially expressed (DE) in fip37-4 and several DE genes involved in auxin homeostasis and flowering possibly explaining P2-04 near WT phenotype. To further understand how AtKH26R472Q rescues fip37-4 T-DNA insertion mutant atkh26 was characterised identifying AtKH26 as a negative regulator of root development, flowering and m6A measurements showed m6A levels to be increased by 5%. Crossing atkh26 with hypomorphic VIRILIZER mutant vir-1 failed to completely suppress vir-1 however m6A levels and root length were increased and displayed earlier flower therefore suggesting complete suppression by mutating AtKH26 is specific to fip37-4. Protein-RNA affinity assay with m6A modified RNA oligos demonstrated both AtKH26 and AtKH26R472Q to preferentially bind to non-modified RNA concluding AtKH26 as an anti-m6A reader and must negatively regulate m6A containing transcripts through some alternative mechanism. Overall, this study provides insight on AtKH26 as a novel KH domain protein involved in regulating plant development and FIP37 directed m6A methylation: likely playing a role in nuclear metabolism of FIP37 mRNA and transcripts involved in root and floral development.

Published
2022

33. Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI

Author

Povsic, Thomas J., Korjian, Serge, Bahit, M. Cecilia, Chi, Gerald, Duffy, Danielle, Alexander, John H., Vinereanu, Dragos, Tricoci, Pierluigi, Mears, Sojaita Jenny, Deckelbaum, Lawrence I., Bonaca, Marc, Ridker, Paul M., Goodman, Shaun G., Cornel, Jan H., Lewis, Basil S., Parkhomenko, Alexander, Lopes, Renato D., Aylward, Philip, Lincoff, A. Michael, Heise, Mark, Sacks, Frank, Nicolau, Jose C., Merkely, Bela, Trebacz, Jaroslaw, Libby, Peter, Nicholls, Stephen J., Pocock, Stuart, Bhatt, Deepak L., Kastelein, John, Bode, Christoph, Mahaffey, Kenneth W., Steg, P. Gabriel, Tendera, Michal, Bainey, Kevin R., Harrington, Robert A., Mehran, Roxana, Duerschmied, Daniel, Kingwell, Bronwyn A., and Gibson, C. Michael

Published
2024
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34. Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial

Author

Goldstein, Daniel J., Chang, Helena L., Mack, Michael J., Voisine, Pierre, Gammie, James S., Marks, Mary E., Iribarne, Alexander, Vengrenyuk, Yuliya, Raymond, Samantha, Taylor, Bradley S., Dagenais, François, Ailawadi, Gorav, Chu, Michael W.A., DiMaio, J. Michael, Narula, Jagat, Moquete, Ellen G., O'Sullivan, Karen, Williams, Judson B., Jr., Crestanello, Juan A., Scavo, Vincent, Puskas, John D., Acker, Michael A., Gillinov, Marc, Gelijns, Annetine C., O'Gara, Patrick T., Moskowitz, Alan J., Alexander, John H., and Bagiella, Emilia

Published
2024
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35. Conceptual Design Report for the LUXE Experiment

Author

Abramowicz, Halina, Acosta, Uwe Hernandez, Altarelli, Massimo, Assmann, Ralph, Bai, Zhaoyu, Behnke, Ties, Benhammou, Yan, Blackburn, Thomas, Boogert, Stewart, Borysov, Oleksandr, Borysova, Maryna, Brinkmann, Reinhard, Bruschi, Marco, Burkart, Florian, Büßer, Karsten, Cavanagh, Niall, Davidi, Oz, Decking, Winfried, Dosselli, Umberto, Elkina, Nina, Fedotov, Alexander, Firlej, Miroslaw, Fiutowski, Tomasz, Fleck, Kyle, Gostkin, Mikhail, Grojean, Christophe, Hallford, John Andrew, Harsh, Harsh, Hartin, Anthony, Heinemann, Beate, Heinzl, Tom, Helary, Louis, Hoffmann, Marius, Huang, Shan, Huang, Xinhe, Idzik, Marek, Ilderton, Anton, Jacobs, Ruth Magdalena, Kaempfer, Burkhard, King, Ben, Lakhno, Hlib, Levanon, Assaf, Levy, Aharon, Levy, Itamar, List, Jenny, Lohmann, Wolfgang, Ma, Teng, Macleod, Alexander John, Malka, Victor, Meloni, Federico, Mironov, Arseny, Morandin, Mauro, Moron, Jakub, Negodin, Evgueni, Perez, Gilad, Pomerantz, Ishay, Poeschl, Roman, Prasad, Rajendra, Quere, Fabien, Ringwald, Andreas, Roedel, Christian, Rykovanov, Sergey, Salgado, Felipe, Santra, Arka, Sarri, Gianluca, Saevert, Alexander, Sbrizzi, Antonio, Schmitt, Stefan, Schramm, Ulrich, Schuwalow, Sergej, Seipt, Daniel, Shaimerdenova, Leila, Shchedrolosiev, Mykyta, Skakunov, Maksim, Soreq, Yotam, Streeter, Matthew, Swientek, Krzysztof, Hod, Noam Tal, Tang, Suo, Teter, Thomas, Thoden, Daniel, Titov, Alexander, Tolbanov, Oleg, Torgrimsson, Greger, Tyazhev, Anton, Wing, Matthew, Zanetti, Marco, Zarubin, Andrei, Zeil, Karl, Zepf, Matt, and Zhemchukov, Aleksey

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Quantum Physics
Abstract

This Conceptual Design Report describes LUXE (Laser Und XFEL Experiment), an experimental campaign that aims to combine the high-quality and high-energy electron beam of the European XFEL with a powerful laser to explore the uncharted terrain of quantum electrodynamics characterised by both high energy and high intensity. We will reach this hitherto inaccessible regime of quantum physics by analysing high-energy electron-photon and photon-photon interactions in the extreme environment provided by an intense laser focus. The physics background and its relevance are presented in the science case which in turn leads to, and justifies, the ensuing plan for all aspects of the experiment: Our choice of experimental parameters allows (i) effective field strengths to be probed at and beyond the Schwinger limit and (ii) a precision to be achieved that permits a detailed comparison of the measured data with calculations. In addition, the high photon flux predicted will enable a sensitive search for new physics beyond the Standard Model. The initial phase of the experiment will employ an existing 40 TW laser, whereas the second phase will utilise an upgraded laser power of 350 TW. All expectations regarding the performance of the experimental set-up as well as the expected physics results are based on detailed numerical simulations throughout.

Published
2021
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37. Finite Element-Based Studies on Shear Connector Failure of Prestressed Concrete Multi-Girder Bridges

Author

Liu, Jiadaren, Alexander, John, Li, Y., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Gupta, Rishi, editor, Sun, Min, editor, Brzev, Svetlana, editor, Alam, M. Shahria, editor, Ng, Kelvin Tsun Wai, editor, Li, Jianbing, editor, El Damatty, Ashraf, editor, and Lim, Clark, editor

Published
2023
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38. Neuro-Adaptive Interface System to Evaluate Product Recommendations in the Context of E-Commerce

Author

Tadson, Bella, Boasen, Jared, Courtemanche, François, Beauchemin, Noémie, Karran, Alexander-John, Léger, Pierre-Majorique, Sénécal, Sylvain, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gerber, Aurona, editor, and Baskerville, Richard, editor

Published
2023
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39. Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial

Author

Lopes, Renato D, Higano, Celestia S, Slovin, Susan F, Nelson, Adam J, Bigelow, Robert, Sørensen, Per S, Melloni, Chiara, Goodman, Shaun G, Evans, Christopher P, Nilsson, Jan, Bhatt, Deepak L, Clarke, Noel W, Olesen, Tine K, Doyle-Olsen, Belinda T, Kristensen, Henriette, Arney, Lauren, Roe, Matthew T, Alexander, John H, Mol-Arts, Mirjam, Mansor-Lefebvre, Samreen, Zubovskiy, Konstantin, Blemings, Allan, Dugi, Klaus, Bloomfield, Gerald, Kontos, Chris, DeVore, Adam, Jordan, Dedrick, Kolls, Bradley, Matthews, Robin, Mehta, Rajendra, Povsic, Thomas J, Morse, Michael, Mahaffey, Kenneth W, Halabi, Susan, Leong, Darryl, Klotz, Laurence, Fleshner, Neil, Jansz, Godfrey, Giddens, Jonathan, Egerdie, Russell, Chin, Joseph, Zadra, Joseph, Casey, Richard, Simard, Jean, Niazi, Tamim, Martin, André-Guy, Babjuk, Marek, Hajek, Jaroslav, Klecka, Jiri, Kubes, Jiri, Schraml, Jan, Jakesova, Jitka, Vanasek, Jaroslav, Melichar, Bohuslav, Seikkula, Heikki, Abdiche, Manouar Samir, Colombel, Marc, Debourdeau, Philippe, Robert, Gregoire, Villers, Arnauld, Ploussard, Guillaume, Pradere, Benjamin, Bruyere, Franck, Descotes, Jean-Luc, Ouzaid, Idir, Winter, Alexander, Hanitzsch, Herbert, Sperling, Herbert, Eckert, Ralf, Hammerer, Peter, Stagge, Elke, Seseke, Florian, Szymula, Silvio, Bamias, Aristotelis, Thanos, Anastasios, Hatzimouratidis, Konstantinos, Mamoulakis, Charalambos, Kalofonos, Haralabos, Oszukowska, Elzbieta, Madziarska, Katarzyna, Fijuth, Jacek, Obarzanowski, Mateusz, Alekseev, Boris, Atduev, Vagif, Pushkar, Dmitri, Veliev, Evgeniy, Zyryanov, Alexander, Petrov, Sergey, Kopyltsov, Evgeny, Kozlov, Vadim, Macko, Ladislav, Dubravicky, Jozef, Polak, Richard, Mir, Obaidullah, Vargovcak, Marek, Mincik, Ivan, Kliment, Jan, Goncalves, Frederico, Mikulas, Juraj, and Sokol, Roman

Subjects
Cancer, Clinical Trials and Supportive Activities, Patient Safety, Aging, Prostate Cancer, Urologic Diseases, Cardiovascular, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Aged, Humans, Leuprolide, Male, Oligopeptides, Prospective Studies, Prostatic Neoplasms, agonists, atherosclerosis, cardiotoxicity, drug therapy, gonadotropin-releasing hormone, prostatic neoplasms, PRONOUNCE Study Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundThe relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains controversial.MethodsIn this international, multicenter, prospective, randomized, open-label trial, men with prostate cancer and concomitant atherosclerotic cardiovascular disease were randomly assigned 1:1 to receive the GnRH antagonist degarelix or the GnRH agonist leuprolide for 12 months. The primary outcome was the time to first adjudicated major adverse cardiovascular event (composite of death, myocardial infarction, or stroke) through 12 months.ResultsBecause of slower-than-projected enrollment and fewer-than-projected primary outcome events, enrollment was stopped before the 900 planned participants were accrued. From May 3, 2016, to April 16, 2020, a total of 545 patients from 113 sites across 12 countries were randomly selected. Baseline characteristics were balanced between study groups. The median age was 73 years, 49.8% had localized prostate cancer; 26.3% had locally advanced disease, and 20.4% had metastatic disease. A major adverse cardiovascular event occurred in 15 (5.5%) patients assigned to degarelix and 11 (4.1%) patients assigned to leuprolide (hazard ratio, 1.28 [95% CI, 0.59-2.79]; P=0.53).ConclusionsPRONOUNCE (A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease) is the first, international, randomized clinical trial to prospectively compare the cardiovascular safety of a GnRH antagonist and a GnRH agonist in patients with prostate cancer. The study was terminated prematurely because of the smaller than planned number of participants and events, and no difference in major adverse cardiovascular events at 1 year between patients assigned to degarelix or leuprolide was observed. The relative cardiovascular safety of GnRH antagonists and agonists remains unresolved. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02663908.

Published
2021

43. The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Jeffries, Neal O., Buxton, Dennis, Geller, Nancy L., Gordon, David, Burke, Catherine, Lee, Albert, Smith, Tyrone, Moy, Claudia S., Gombos, Ilana Kogan, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Shah, Kinjal, Overbey, Jessica R., Pan, Stephanie, Chang, Helena, Chase, Melissa, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Santos, Milerva, Ye, Xia, Mack, Michael, Winkle, Rachelle, Boswell, Haley, Fenlon, Amanda, Johnson, Melissa, Jones, Jessica, Kolb, Megan, Lam, Sarah, Miranda, Lucy, Ward, Jackie, Whitman, Renessa, Zingler, Brittany, Ryan, William, Smith, Robert L., Grayburn, Paul, Nosnik, Pedro, Gillinov, A. Marc, Blackstone, Eugene H., Moazami, Nader, Starling, Randall C., Barzilai, Benico, Grimm, Richard A., Soltesz, Edward G., Katzan, Irene, Strippy, Brian, Smith, Shoi, Garcia, Michelle, Alice bowman, Mary, Geither, Carrie, Wang, Robert, Argenziano, Michael, Borger, Michael, Takayama, Hiroo, Leon, Martin B., Goldsmith, Lyn, Schwartz, Allan, Sookraj, Nadia, McCright-Gill, Talaya, Sreekanth, Sowmya, McCullough, Jock N., Iribarne, Alexander, DeSimone, Joseph P., DiScipio, Anthony W., Stokes, Henry, Ivany, Amanda St., Petty, Gaylin, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Huber, Joel, Morganlander, Joel, Mathew, Joseph P., Welsh, Stacey, Casalinova, Sarah, Johnson, Victoria, Lane, Kathleen, Smith, Derek, Tipton, Greg, Berry, Mark F., Williams, Judson B., Englum, Brian, Hartwig, Matthew, Thourani, Vinod H., Guyton, Robert, Lattouf, Omar, Chen, Edward, Vega, J. David, Baer, Jefferson, Nguyen, Duc, Halkos, Michael, Baio, Kim, Prince, Tamara, Cook, Natascha, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, Laforce, Robert, Jr., O'Connor, Kim, Dussault, Gladys, Caouette, Manon, Tremblay, Hugo, Gagne, Nathalie, Dumont, Julie, Landry, Patricia, Groh, Mark A., Trichon, Benjamin H., Binns, Oliver A., Ely, Stephen W., Johnson, Alan M., Hansen, Todd H., Short, John G., Taylor, Reid D., Mangusan, Ralph, Nanney, Tracy, Aubart, Holly, Cross, Kristin, McPeters, Leslie, Riggsbee, Christina, Rixey, Lucy, Michler, Robert E., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo A., Taub, Cynthia, Spevack, Daniel, Kirchoff, Kathryn, Meli, Rebecca, Garcia, Juan, Goldenberg, Jon, Kealy, Lauren, Perrault, Louis P., Bouchard, Denis, Tanguay, Jean François, O'Meara, Eileen, Lacharité, Jonathan, Robichaud, Sophie, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Kumkumian, Greg, Milner, Mark, Nadareishvili, Zurab, Whitson, Bryan A., Hasan, Ayesha, McDavid, Asia, Fadorsen, Denise, Ouzounian, Maral, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Fumakia, Nishit, Christie, Shakira, Mullen, John C., Bissonauth, Asvina, Hripko, Alexandra, Gammie, James S., Noor, Zahid, Mackowick, Kristen, Deasey, Stephanie, Al-Suqi, Manal, Collins, Julia, Acker, Michael A., Messé, Steven, Kirkpatrick, James, Mayer, Mary Lou, McDonald, Caitlin, Fok, Holley, Maffei, Breanna, Cresse, Stephen, Gepty, Christine, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Heck, Christi, Hackmann, Amy, Baker, Craig, Fleischman, Fernando, Cunningham, Mark, Lozano, Edward, Hernandez, Michelle, Ailawadi, Gorav, Kron, Irving L., Johnston, Karen, Ghanta, Ravi K., Dent, John M., Kern, John, Yarboro, Leora, Ragosta, Michael, Annex, Brian, Bergin, Jim, Burks, Sandra, Cosner, Mike, Green, China, Loya, Samantha, Kim, Hye Ryun, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Gottesman, Rebecca, Haigney, Mark, Holubkov, Richard, Iadecola, Constantino, Jacobs, Alice, Meslin, Eric M., Murkin, John M., Spertus, John A., Sellke, Frank, McDonald, Cheryl L., Canty, John, Dickert, Neal, Ikonomidis, John S., Kim, KyungMann, Williams, David O., Yancy, Clyde W., Chaturvedi, Seemant, Chimowitz, Marc, Fang, James C., Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Cook, Jennifer, D'Alessandro, David, Han, Frederick, Pinney, Sean, Walsh, Mary N., Greer, David, Ishida, Koto, Stapf, Christian, Hung, Judy, Zeng, Xin, Hung, David, Satitthummanid, Sudarat, Billelo, Michel, Davatzikos, Christos, Erus, Guray, Karpf, Lauren, Desiderio, Lisa, Browndyke, Jeffrey N., James, Michael L., Toulgoat-Dubois, Yanne, Brassard, Rachele, Virmanu, Renu, Romero, Maria E., Braumann, Ryan, Messé, Steven R., Mack, Michael J., Southerland, Andrew M., Moy, Claudia Scala, and Bowdish, Michael E.

Published
2024
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45. Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK

Author

Giles Dixon, Samuel Hague, Sarah Mulholland, Huzaifa Adamali, Aye Myat Noe Khin, Hannah Thould, Roisin Connon, Paul Minnis, Eoin Murtagh, Fasihul Khan, Sameen Toor, Alexandra Lawrence, Marium Naqvi, Alex West, Robina K. Coker, Katie Ward, Leda Yazbeck, Simon Hart, Theresa Garfoot, Kate Newman, Pilar Rivera-Ortega, Lachlan Stranks, Paul Beirne, Jessica Bradley, Catherine Rowan, Sarah Agnew, Mahin Ahmad, Lisa G. Spencer, Joshua Aigbirior, Ahmed Fahim, Andrew M. Wilson, Elizabeth Butcher, Sy Giin Chong, Gauri Saini, Sabrina Zulfikar, Felix Chua, Peter M. George, Maria Kokosi, Vasileios Kouranos, Philip Molyneaux, Elisabetta Renzoni, Benedetta Vitri, Athol U. Wells, Lisa M. Nicol, Stephen Bianchi, Raman Kular, HuaJian Liu, Alexander John, Sarah Barth, Melissa Wickremasinghe, Ian A. Forrest, Ian Grimes, A. John Simpson, Sophie V. Fletcher, Mark G. Jones, Emma Kinsella, Jennifer Naftel, Nicola Wood, Jodie Chalmers, Anjali Crawshaw, Louise E. Crowley, Davinder Dosanjh, Christopher C. Huntley, Gareth I. Walters, Timothy Gatheral, Catherine Plum, Shiva Bikmalla, Raja Muthusami, Helen Stone, Jonathan C.L. Rodrigues, Krasimira Tsaneva-Atanasova, Chris J. Scotton, Michael A. Gibbons, and Shaney L. Barratt

Subjects
Medicine
Abstract

Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting. Methods 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022. Summary data regarding underlying diagnosis, pulmonary function tests, diagnostic criteria, radiological appearance, concurrent immunosuppressive therapy and drug tolerability were collected via electronic survey. Results 24 UK prescribing centres responded to the service evaluation invitation. Between 17 November 2021 and 30 September 2022, 1120 patients received a multidisciplinary team recommendation to commence nintedanib for PF-ILD. The most common underlying diagnoses were hypersensitivity pneumonitis (298 out of 1120, 26.6%), connective tissue disease associated ILD (197 out of 1120, 17.6%), rheumatoid arthritis associated ILD (180 out of 1120, 16.0%), idiopathic nonspecific interstitial pneumonia (125 out of 1120, 11.1%) and unclassifiable ILD (100 out of 1120, 8.9%). Of these, 54.4% (609 out of 1120) were receiving concomitant corticosteroids, 355 (31.7%) out of 1120 were receiving concomitant mycophenolate mofetil and 340 (30.3%) out of 1120 were receiving another immunosuppressive/modulatory therapy. Radiological progression of ILD combined with worsening respiratory symptoms was the most common reason for the diagnosis of PF-ILD. Conclusion We have demonstrated the use of nintedanib for the treatment of PF-ILD across a broad range of underlying conditions. Nintedanib is frequently co-prescribed alongside immunosuppressive and immunomodulatory therapy. The use of nintedanib for the treatment of PF-ILD has demonstrated acceptable tolerability in a real-world setting.

Published
2024
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46. Modelling the transition to a low-carbon energy supply

Author

Kell, Alexander John Michael

Abstract

A transition to a low-carbon electricity supply is crucial to limit the impacts of climate change. Reducing carbon emissions could help prevent the world from reaching a tipping point, where runaway emissions are likely. Runaway emissions could lead to extremes in weather conditions around the world - especially in problematic regions unable to cope with these conditions. However, the movement to a low-carbon energy supply can not happen instantaneously due to the existing fossil-fuel infrastructure and the requirement to maintain a reliable energy supply. Therefore, a low-carbon transition is required, however, the decisions various stakeholders should make over the coming decades to reduce these carbon emissions are not obvious. This is due to many long-term uncertainties, such as electricity, fuel and generation costs, human behaviour and the size of electricity demand. A well choreographed low-carbon transition is, therefore, required between all of the heterogenous actors in the system, as opposed to changing the behaviour of a single, centralised actor. The objective of this thesis is to create a novel, open-source agent-based model to better understand the manner in which the whole electricity market reacts to different factors using state-of-the-art machine learning and artificial intelligence methods. In contrast to other works, this thesis looks at both the long-term and short-term impact that different behaviours have on the electricity market by using these state-of-the-art methods. Specifically, we investigate the following applications: 1. Predictions are made to predict electricity demand in the short-term. We model the impact that poor predictions have on investments in electricity generators and utilisation over the long-term. We find that poor short-term predictions lead to a higher proportion of coal, gas, and nuclear power plants. 2. We devise a long-term carbon tax for the United Kingdom using a genetic algorithm approach. We find multiple strategies that can minimise both long-term carbon emissions and electricity cost. 3. Oligopolies can have a detrimental effect on an electricity market by raising electricity prices without an increase in benefit to users. Reinforcement learning can be used to devise intelligent bidding strategies which are based upon forecasts and predictions of other agent behaviour to maximise revenues. These behaviours can not be modelled through traditional rule-based algorithms. We use reinforcement learning to model strategic bidding into the electricity market, and find ways to limit the impact of this strategic bidding through a market cap. We find that introducing a market cap can significantly reduce the ability for oligopolies to manipulate the market. These studies require a number of core challenges to be addressed to ensure our agent-based model, ElecSim, is fit for purpose. These are: 1. Development of the ElecSim model, where the replication of the pertinent features of the electricity market was required. For example, generation company investment behaviour, electricity market design and temporal granularity. We find that the temporal granularity of the model has a large impact on accuracy of the model, but with suitably chosen representative days calibration is possible to accurately model a time period. 2. The complexity of a model increases with the replication of increasing market features. Therefore, optimisation of the code was required to maintain computational tractability, to allow for multiple scenario runs. This enabled us to run multiple iterations to train different machine learning techniques. 3. Once the model has been developed, its long-term behaviour must be verified to ensure accuracy. In this work, cross-validation was used to both validate and calibrate ElecSim. We are able to accurately model a historic period observed in the real-world with this approach 4. To ensure that the salient parameters are found, a sensitivity analysis was run. In addition, various example scenarios were generated to show the behaviour of the model. We find that the input parameters, such as the cost of capital have a disproportionate effect on the long-term electricity mix. The findings outlined previously demonstrate the ability for artificial intelligence, machine learning and agent-based models to perform complex analyses in an uncertain system. We find that solely focusing on the accuracy of machine learning techniques, for instance, misses out on a significant amount research potential. We instead argue, that by further developing these research themes, we are able to better understand the electricity market system of the United Kingdom.

Published
2021

47. English sub-regional planning : governance, institutions and outcomes in East Anglia

Author

Hollingsworth, Alexander John and Valler, David

Abstract

After successive experiments with top-down and formalised regionalism, the current phase in English local governance is considerably more mixed, and includes flexibly defined and bounded sub-regional institutions. If regional institutions shaped by national actors have proved to be brittle as a consequence of being not arenas for political contestation but objects of it, is it possible that sub-regions shaped by local actors might be more durable and more capable of delivering national and local objectives? Starting from Bhaskar's realist approach and Jessop's insight that agential actors and the structures within which they operate are mutually constitutive, and making use of tools and terms from Third Wave Institutionalism, this research creates a framework to show how the narrative, practices and rules constraints of institutions used for sub-regional planning both shape, and are simultaneously shaped by, the varied strategic ambitions of local actors. The research focus is Eastern England, specifically the three major urban areas of Ipswich, Norwich and Cambridge. Eastern England had the lowest level of regional identity during the New Labour period of regional governance, and has a long history of defying efforts to clearly define what the region consists of. By contrast these three urban areas have a clear identity, but are all significantly 'underbounded', with major parts of the built up areas of each sitting outside the formal boundary of their respective local authorities, and insufficient capacity within these boundaries to address pressures for housing supply, infrastructure investment and economic growth. Any attempt by local actors to address planning problems such as these requires a sub-regional approach, and in each case study different approaches have been taken. A key finding from the research is that when actors perceive an existential threat, whether real or imagined, to the institution through which they access power, they put a greater relative emphasis on strategies that promote or preserve that institution. This increased emphasis is associated with negative narratives, uncooperative behaviours and a decline in institutional stability. This pattern can be seen limiting strategic ambitions in Ipswich, at the heart of negative discourse and behaviours in Norwich, and in growing tensions and challenges in Cambridge.

Published
2021
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48. An exploration of value discourses in legal education

Author

Nicholson, Alexander John and Marson, James

Abstract

In September 2021, the regulator of the largest branch of the legal profession in England and Wales introduced a radically reformed qualification framework. Not only does this arguably of itself precipitate the need for transformational change within the legal education market, but it comes at a time when societal rhetoric is questioning the value of higher education more widely. When one is asked to speak about the "value" of legal education, the resultant discourse tends at least initially to focus on instrumental aspects, and there is often an economic flavour. However, dig a little beneath the surface and it soon becomes clear that individual perceptions of value are multifaceted, inherently subjective, and subject to a constant process of evolution. The overarching aim of this programme of research was to explore the value discourses that exist within legal education and thereby formulate recommendations for reform. This aim was achieved using a predominantly pragmatist approach, and comprising a mixed methods design - albeit with an exclusive focus on doctrinal, theoretical, socio-legal, and qualitative methods, given the subjective nature of "value". The collective contribution of the eleven publications presented in this work is three-fold. First, they highlight the complexity of the value concept - specifically in relation to its application within legal education - and propose new theoretical modelswhich can assist legal and other education providers in evaluating, creating, and articulating value more holistically. Second, they illustrate the value of interdisciplinary and socio-legal research, and in so doing present important evidence to further support calls for greater interdisciplinarity within legal education. Finally, they highlight opportunities where an exploration of other value discourses might enhance educational and/or research outcomes by revealing previously hidden perspectives.

Published
2021

49. Systems of nonlinear PDEs arising from multi-dimensional and multi-fluid viscous shear flows

Author

Alexander, John and Papageorgiou, Demetrios

Abstract

In this thesis, mathematical systems of coupled differential equations arising in fluid dynamics are studied; motivated by the insight they provide in understanding and prompting experimental results as well as the opportunity they present to develop tools to investigate their rich dynamical system. To cover a wide range of physical arrangements and parabolic PDEs, three problems are posed; connected via the types of equations which govern their motion and the techniques used to study them. The multiplicity of the equations is first generated by the interaction between a fluid and a flexible substrate, where the evolution of the fluid's free-boundaries are coupled through the fluid. The resonant interaction is shown to cause linear instabilities at a range of Reynolds numbers, from the Stokes flow limit to very high values where a Chebyshev-Tau numerical approach was required; providing a foundation for future nonlinear studies. Similarly, the evolution of the two free-boundaries in a three-layer channel flow, applicable in microfluidics, form a system of PDEs, where novel, asymmetric instabilities were found in the inertialess regime. Numerical simulations demonstrated complex, nonlinear behaviour; supporting the transition of the parabolic PDEs' advection component from hyperbolic to elliptic. Modern modelling techniques of falling films (namely WIBL) consist of multiple evolution equations for the properties of the fluid, and are applied here to study the stability and dynamics of rivulets supporting travelling lenses, as observed in previous experiments. A quasi-static linear stability analysis about the rivulets provides the growth rate, spacing and small-amplitude surface profiles of the subsequent linear instability. Further numerical simulations extended these into the nonlinear regime where three-dimensional travelling waves, qualitatively comparable to snapshots of those seen in experiment, were found for the Benney equation and similar form, large-time dewetting waves and time-periodicity for the higher-order models. Supplementary code is provided in accompanying repositories.

Published
2021
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