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11. Mesothelioma: Scientific clues for prevention, diagnosis, and therapy.

Author

Carbone, Michele, Adusumilli, Prasad S, Alexander, H Richard, Baas, Paul, Bardelli, Fabrizio, Bononi, Angela, Bueno, Raphael, Felley-Bosco, Emanuela, Galateau-Salle, Francoise, Jablons, David, Mansfield, Aaron S, Minaai, Michael, de Perrot, Marc, Pesavento, Patricia, Rusch, Valerie, Severson, David T, Taioli, Emanuela, Tsao, Anne, Woodard, Gavitt, Yang, Haining, Zauderer, Marjorie G, and Pass, Harvey I

Subjects
Pleura, Humans, Mesothelioma, Pleural Neoplasms, Genetic Predisposition to Disease, Asbestos, Ubiquitin Thiolesterase, Tumor Suppressor Proteins, Diagnostic Errors, Prognosis, Combined Modality Therapy, Pneumonectomy, Incidence, Inhalation Exposure, Occupational Exposure, Germ-Line Mutation, International Cooperation, United States, Australia, Europe, Molecular Targeted Therapy, Carcinogenesis, Biomarkers, Tumor, Global Burden of Disease, Antineoplastic Agents, Immunological, BRCA1-associated protein 1, asbestos, cancer syndromes, chromothripsis, gene-environment interaction, immunotherapy, mesothelioma, Lung, Rare Diseases, Lung Cancer, Cancer, Prevention, Good Health and Well Being, Clinical Sciences, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that continue to use large amounts of asbestos. The incidence rate of mesothelioma has decreased in Australia, the United States, and Western Europe, where the use of asbestos was banned or strictly regulated in the 1970s and 1980s, demonstrating the value of these preventive measures. However, in these same countries, the overall number of deaths from mesothelioma has not decreased as the size of the population and the percentage of old people have increased. Moreover, hotspots of mesothelioma may occur when carcinogenic fibers that are present in the environment are disturbed as rural areas are being developed. Novel immunohistochemical and molecular markers have improved the accuracy of diagnosis; however, about 14% (high-resource countries) to 50% (developing countries) of mesothelioma diagnoses are incorrect, resulting in inadequate treatment and complicating epidemiological studies. The discovery that germline BRCA1-asssociated protein 1 (BAP1) mutations cause mesothelioma and other cancers (BAP1 cancer syndrome) elucidated some of the key pathogenic mechanisms, and treatments targeting these molecular mechanisms and/or modulating the immune response are being tested. The role of surgery in pleural mesothelioma is controversial as it is difficult to predict who will benefit from aggressive management, even when local therapies are added to existing or novel systemic treatments. Treatment outcomes are improving, however, for peritoneal mesothelioma. Multidisciplinary international collaboration will be necessary to improve prevention, early detection, and treatment.

Published
2019

13. Hyperthermic Regional Perfusion for Melanoma of the Limbs

Author

Tyler, Douglas S., Fraker, Douglas L., Hoekstra, Harald J., Alexander, H. Richard, Jr., Balch, Charles M., editor, Atkins, Michael B., editor, Garbe, Claus, editor, Gershenwald, Jeffrey E., editor, Halpern, Allan C., editor, Kirkwood, John M., editor, McArthur, Grant A., editor, Thompson, John F., editor, and Sober, Arthur J., editor

Published
2020
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20. Recurrence‐free survival dynamics following adjuvant chemotherapy for resected colorectal cancer: A systematic review of randomized controlled trials

Author

Vail, Emma, primary, Choubey, Ankur P., additional, Alexander, H. Richard, additional, August, David A., additional, Berry, Abril, additional, Boland, Patrick M., additional, Eskander, Mariam F., additional, Grandhi, Miral S., additional, Haliani, Brittany, additional, In, Haejin, additional, Kennedy, Timothy J., additional, Langan, Russell C., additional, Maggi, Jason C., additional, Pitt, Henry A., additional, Ganesan, Shridar, additional, and Ecker, Brett L., additional

Published
2024
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22. Hepatic Perfusion for Diffuse Metastatic Cancer to the Liver

Author

Alexander, H. Richard and Devi-Chou, Virginia

Abstract

The management of patients with diffuse liver metastases remains a significant clinical challenge. In many cancer patients, metastatic disease may be isolated to the liver or the liver may be the dominant site of progressive metastatic cancer. In this setting, progression of disease in the liver generally is the most significant cause of morbidity and mortality.

Published
2025
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24. Association between SMAD4 Mutations and GATA6 Expression in Paired Pancreatic Ductal Adenocarcinoma Tumor Specimens: Data from Two Independent Molecularly-Characterized Cohorts

Author

Greendyk, Joshua D., primary, Allen, William E., additional, Alexander, H. Richard, additional, Beninato, Toni, additional, Eskander, Mariam F., additional, Grandhi, Miral S., additional, Kennedy, Timothy J., additional, Langan, Russell C., additional, Maggi, Jason C., additional, De, Subhajyoti, additional, Court, Colin M., additional, and Ecker, Brett L., additional

Published
2023
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30. It Is Time

Author

Turaga, Kiran K., Gamblin, T. Clark, Edwards, Robert, Alexander, H. Richard, and Bartlett, David

Published
2019
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31. Abstract 6225: SERPINB3 promotes the aggressive basal-like/squamous subtype and correlates with poor prognosis in pancreatic ductal adenocarcinoma through metabolic reprogramming

Author

Ohara, Yuuki, primary, Tang, Wei, additional, Huaitian, Liu, additional, Yang, Shouhui, additional, He, Peijun, additional, Cawley, Helen, additional, Valenzuela, Paloma, additional, Zhang, Lin, additional, Gaedcke, Jochen, additional, Ghadimi, B. Michael, additional, Gaida, Matthias M., additional, Bergmann, Frank, additional, Alexander, H. Richard, additional, Hanna, Nader, additional, Ambs, Stefan, additional, and Hussain, S. Perwez, additional

Published
2023
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32. Supplementary Table S2 from Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

Author

Zhang, Geng, primary, He, Peijun, primary, Tan, Hanson, primary, Budhu, Anuradha, primary, Gaedcke, Jochen, primary, Ghadimi, B. Michael, primary, Ried, Thomas, primary, Yfantis, Harris G., primary, Lee, Dong H., primary, Maitra, Anirban, primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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33. Supplementary Materials and Methods from Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer

Author

Wang, Jian, primary, Yang, Shouhui, primary, He, Peijun, primary, Schetter, Aaron J., primary, Gaedcke, Jochen, primary, Ghadimi, B. Michael, primary, Ried, Thomas, primary, Yfantis, Harris G., primary, Lee, Dong H., primary, Gaida, Matthias M., primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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34. Supplementary Figure S2 from Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

Author

Zhang, Geng, primary, He, Peijun, primary, Tan, Hanson, primary, Budhu, Anuradha, primary, Gaedcke, Jochen, primary, Ghadimi, B. Michael, primary, Ried, Thomas, primary, Yfantis, Harris G., primary, Lee, Dong H., primary, Maitra, Anirban, primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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35. Supplementary Table S4-S7 from Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer

Author

Wang, Jian, primary, Yang, Shouhui, primary, He, Peijun, primary, Schetter, Aaron J., primary, Gaedcke, Jochen, primary, Ghadimi, B. Michael, primary, Ried, Thomas, primary, Yfantis, Harris G., primary, Lee, Dong H., primary, Gaida, Matthias M., primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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36. Supplementary Table S3 from Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer

Author

Wang, Jian, primary, Yang, Shouhui, primary, He, Peijun, primary, Schetter, Aaron J., primary, Gaedcke, Jochen, primary, Ghadimi, B. Michael, primary, Ried, Thomas, primary, Yfantis, Harris G., primary, Lee, Dong H., primary, Gaida, Matthias M., primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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37. Supplementary Materials and Methods from Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

Author

Zhang, Geng, primary, He, Peijun, primary, Tan, Hanson, primary, Budhu, Anuradha, primary, Gaedcke, Jochen, primary, Ghadimi, B. Michael, primary, Ried, Thomas, primary, Yfantis, Harris G., primary, Lee, Dong H., primary, Maitra, Anirban, primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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38. Supplementary Tables S1-S9 from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2

Author

Yang, Shouhui, primary, He, Peijun, primary, Wang, Jian, primary, Schetter, Aaron, primary, Tang, Wei, primary, Funamizu, Naotake, primary, Yanaga, Katsuhiko, primary, Uwagawa, Tadashi, primary, Satoskar, Abhay R., primary, Gaedcke, Jochen, primary, Bernhardt, Markus, primary, Ghadimi, B. Michael, primary, Gaida, Matthias M., primary, Bergmann, Frank, primary, Werner, Jens, primary, Ried, Thomas, primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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39. Supplementary Figure 1-12 from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2

Author

Yang, Shouhui, primary, He, Peijun, primary, Wang, Jian, primary, Schetter, Aaron, primary, Tang, Wei, primary, Funamizu, Naotake, primary, Yanaga, Katsuhiko, primary, Uwagawa, Tadashi, primary, Satoskar, Abhay R., primary, Gaedcke, Jochen, primary, Bernhardt, Markus, primary, Ghadimi, B. Michael, primary, Gaida, Matthias M., primary, Bergmann, Frank, primary, Werner, Jens, primary, Ried, Thomas, primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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41. Data from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2

Author

Yang, Shouhui, primary, He, Peijun, primary, Wang, Jian, primary, Schetter, Aaron, primary, Tang, Wei, primary, Funamizu, Naotake, primary, Yanaga, Katsuhiko, primary, Uwagawa, Tadashi, primary, Satoskar, Abhay R., primary, Gaedcke, Jochen, primary, Bernhardt, Markus, primary, Ghadimi, B. Michael, primary, Gaida, Matthias M., primary, Bergmann, Frank, primary, Werner, Jens, primary, Ried, Thomas, primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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43. Supplementary Information from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2

Author

Yang, Shouhui, primary, He, Peijun, primary, Wang, Jian, primary, Schetter, Aaron, primary, Tang, Wei, primary, Funamizu, Naotake, primary, Yanaga, Katsuhiko, primary, Uwagawa, Tadashi, primary, Satoskar, Abhay R., primary, Gaedcke, Jochen, primary, Bernhardt, Markus, primary, Ghadimi, B. Michael, primary, Gaida, Matthias M., primary, Bergmann, Frank, primary, Werner, Jens, primary, Ried, Thomas, primary, Hanna, Nader, primary, Alexander, H. Richard, primary, and Hussain, S. Perwez, primary

Published
2023
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48. Malignant Peritoneal Mesothelioma

Author

Mangiameli, David P., Libutti, Steven K., Pingpank, James F., Alexander, H. Richard, Teicher, Beverly A., editor, Schlag, Peter M., editor, Stein, Ulrike, editor, and Eggermont, Alexander M. M., editor

Published
2007
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