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2. CD200 Expression Marks a Population of Quiescent Limbal Epithelial Stem Cells with Holoclone Forming Ability

Author

Sanja, Bojic, Dean, Hallam, Nuno, Alcada, Ali, Ghareeb, Rachel, Queen, Sagoo, Pervinder, Harley, Buck, Aya, Amitai Lange, Gustavo, Figueiredo, Paul, Rooney, Miodrag, Stojkovic, Alex, Shortt, Francisco C, Figueiredo, and Majlinda, Lako

Subjects
Adult, Aged, 80 and over, Male, Antigens, CD, Humans, Epithelial Cells, Female, Limbus Corneae, Middle Aged, Aged
Abstract

One of the main challenges in limbal stem cell (LSC) biology and transplantation is the lack of definitive cell surface markers which can be used to identify and enrich viable LSCs. In this study, expression of 361 cell surface proteins was assessed in ex vivo expanded limbal epithelial cells. One marker, CD200 was selected for further characterization based on expression in a small subset of limbal epithelial cells (2.25% ± 0.69%) and reduced expression through consecutive passaging and calcium induced differentiation. CD200 was localized to a small population of cells at the basal layer of the human and mouse limbal epithelium. CD200

Published
2018

3. Defining Ocular Surface Disease Activity and Damage Indices by an International Delphi Consultation

Author

Priscilla A. Mathewson, Geraint P. Williams, Stephanie L. Watson, James Hodson, Anthony J. Bron, Saaeha Rauz, Sajjad Ahmad, Anthony Bron, Matthew Burton, John K. Dart, Francisco Figueiredo, Gerd Geerling, Nicholas Hawksworth, Deborah Jacobs, Stephen Kaye, S. Sai Kolli, D. Frank Larkin, Sanjay Mantry, Philip I. Murray, Christopher Liu, Alex Shortt, Paul J. Tomlins, David Verity, and Colin Willoughby

Subjects
medicine.medical_specialty, Eye Diseases, Modified delphi, Delphi method, Terminology, Cornea, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, medicine, Humans, Oculoplastics, Grading (education), Referral and Consultation, computer.programming_language, 030203 arthritis & rheumatology, Ocular surface disease, business.industry, Surgery, Clinical trial, Ophthalmology, Tears, 030221 ophthalmology & optometry, Physical therapy, business, computer, Conjunctiva, Delphi
Abstract

Purpose Unifying terminology for the description of ocular surface disease (OSD) is vital for determining treatment responses and ensuring robust clinical trial outcomes. To date, there are no agreed parameters describing ‘activity' and ‘damage' phases of disease. Methods A working group of international experts in OSD, oculoplastics, and uveitis from a range of backgrounds (university, teaching, district general and private hospitals) participated in a modified Delphi consensus-building exercise (October 31, 2011 to March 20, 2015). Two steering group meetings took place in which factors based upon published literature were discussed and supplemented with anonymous web-based questionnaires to refine clinical indices according to ‘activity' (reversible changes resulting directly from the inflammatory process) and/or ‘damage' (persistent, >6 months duration) changes resulting from previously active disease that are cumulative and irreversible). Results The recommended set of clinical parameters for the assessment of OSD encompasses 68 clinical indices and 22 ancillary grading tools (in parenthesis) subdivided by anatomical domain as follows: 4(4) tear-film, eyelid 21(3), 17(3) conjunctiva, 15(10) cornea and 11(2) Anterior Chamber/Sclera. Of these; 17(2) were considered as measures of clinical activity, 27(3) as damage, 1(8) as measures of both activity and damage. Twenty-three clinical descriptors and 9 tools did not reach the threshold for inclusion into the main standard set. These were defined as ‘second tier' parameters for use in special clinical settings. Conclusion These core parameters provide the first description of ‘activity' and ‘damage' relevant to OSD and provide a platform for the future development of scoring scales for each parameter.

Published
2016

4. List of Contributors

Author

Anthony P Adamis, Grazyna Adamus, Daniel M Albert, Ann-Christin Albertsmeyer, Nishani Amerasinghe, Michael G Anderson, Sally S Atherton, Tin Aung, Rebecca S Bahn, David Sander Bardenstein, Neal P Barney, David C Beebe, Adrienne Berman, Audrey M Bernstein, Pooja Bhat, Douglas Borchman, Stephen Brocchini, Claude Burgoyne, Michelle Trager Cabrera, Richard J Cenedella, Jin-Hong Chang, Aimee Chappelow, Anuj Chauhan, Abbot F Clark, Ellen B Cook, Zélia M Corrêa, Scott Cousins, Gerald Cox, Scott Adam Croes, Karl G Csaky, Annegret Hella Dahlmann-Noor, Reza Dana, Helen Danesh-Meyer, Julie T Daniels, Darlene A Dartt, Mohammad H Dastjerdi, Nigel W Daw, Daniel G Dawson, Alejandra de Alba Campomanes, Joseph L Demer, Suzanne M Dintzis, J Crawford Downs, Henry Edelhauser, David Ellenberg, Victor Elner, Steven K Fisher, Robert Folberg, C Stephen Foster, Gary N Foulks, Frederick T Fraunfelder, Frederick W Fraunfelder, Anne Fulton, Ronald Gaster, Stylianos Georgoulas, Michael S Gilmore, Ilene K Gipson, Michaël J A Girard, Lynn K Gordon, Irene Gottlob, John D Gottsch, Frank M Graziano, Hans E Grossniklaus, Deborah Grzybowski, Clyde Guidry, Neeru Gupta, David H Gutmann, Vinay Gutti, John R Guy, J William Harbour, Mary Elizabeth Hartnett, Sohan S Hayreh, Susan Heimer, Robert Hess, Nancy M Holekamp, Suber S Huang, Sudha K Iyengar, Allen T Jackson, L Alan Johnson, Peter F Kador, Alon Kahana, Randy Kardon, Maria Cristina Kenney, Timothy Scott Kern, Peng Tee Khaw, Alice S Kim, Henry Klassen, Paul Knepper, Jane F Koretz, Mirunalini Kumaradas, Jonathan H Lass, David Lederer, Mark Lesk, Leonard A Levin, Geoffrey P Lewis, Zhuqing Li, Amy Lin, Robert A Linsenmeier, Robert Listernick, Martin Lubow, Andrew Maniotis, Pascale Massin, Katie Matatall, Russell L McCally, Stephen D McLeod, Muhammad Memon, Joan W Miller, Austin K Mircheff, Jay Neitz, Maureen Neitz, Christine C Nelson, Robert Nickells, Robert B Nussenblatt, Joan M O’Brien, Daniel T Organisciak, Michel Paques, Heather R Pelzel, Shamira Perera, Eric A Pierce, Jean Pournaras, Jonathan T Pribila, Frank A Proudlock, Xiaoping Qi, Narsing A Rao, Robert Ritch, Joseph F Rizzo, Michael D Roberts, James T Rosenbaum, Barry Rouse, Daniel R Saban, Alfredo A Sadun, Abbas K Samadi, Pranita Sarangi, Andrew P Schachat, Joel E Schechter, A Reagan Schiefer, Ursula Schlötzer-Schrehardt, Ingo Schmack, Leopold Schmetterer, Genevieve Aleta Secker, Srilakshmi M Sharma, James A Sharpe, Heather Sheardown, Alex Shortt, Ying-Bo Shui, Ian Sigal, James L Stahl, Roger F Steinert, Arun N E Sundaram, Janet S Sunness, Nathan T Tagg, Daniela Toffoli, Cynthia A Toth, Elias I Traboulsi, James C Tsai, Budd Tucker, Russell N Van Gelder, Hans Eberhard Völcker, Christopher S von Bartheld, Jianhua Wang, Judith West-Mays, Corey B Westerfeld, Steven E Wilson, Fabricio Witzel de Medeiros, Chih-Wei Wu, Ai Yamada, Steven Yeh, Thomas Yorio, Michael J Young, Terri L Young, Yeni H Yücel, Beatrice Y J T Yue, Marco A Zarbin, Xinyu Zhang, and Mei Zheng

Published
2010
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