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This article, titled "Editorial: Cannabis and mental health: is it possible to predict safe use in the era of legalization?" explores the intersection of cannabis use and mental health. It discusses the detrimental effects of heavy cannabis use on mental health, such as the onset of schizophrenia, amotivation syndrome, exacerbation of bipolar disorder symptoms, and intensification of PTSD symptoms. The article also highlights the need to understand the risks associated with cannabis use, especially among high-risk individuals, in order to guide educational efforts and minimize harm. The research topic includes five studies that examine the relative risks and potential benefits of cannabis use, as well as strategies for risk mitigation and education. [Extracted from the article]