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261 results on '"Alessi-Severini, Silvia"'

2. Exploration of individual socioeconomic and health-related characteristics associated with human papillomavirus vaccination initiation and vaccination series completion among adult females: A comprehensive systematic evidence review with meta-analysis

Author

Okoli, George N., Neilson, Christine J., Grossman Moon, Alexandra, Kimmel Supron, Hannah, Soos, Alexandra E., Grewal, Avneet, Etsell, Katharine, Alessi-Severini, Silvia, Richardson, Caroline, and Harper, Diane M.

Published
2024
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11. Antiseizure medication use during pregnancy and neonatal growth outcomes: A systematic review and meta‐analysis.

Author

Lavu, Alekhya, Vaccaro, Christine, Zusman, Enav, Aboulatta, Laila, Aloud, Basma, Alessi‐Severini, Silvia, Haidar, Lara, Peymani, Payam, Ng, Marcus C., Ruth, Chelsea, Falk, Jamison, Desrochers, Brianne, Valencia, Eunice, Shouman, Walid, Rabbani, Rasheda, and Eltonsy, Sherif

Subjects
LOW birth weight, PREGNANT women, SMALL for gestational age, BIRTH weight, ANTICONVULSANTS
Abstract

Aims: We aimed to systematically synthesize the current published literature on neonatal growth outcomes associated with antiseizure medication (ASM) use during pregnancy. Methods: We searched seven databases, from inception to 23 March 2022. We investigated small for gestational age (SGA) and low birth weight (LBW) as primary outcomes and birth weight, birth height, cephalization index and head circumference as secondary outcomes. The primary analysis included pregnant people exposed to any ASM compared with unexposed pregnant people. Subgroup analysis included ASM class analysis, within epilepsy group analysis and polytherapy compared to monotherapy. Results: We screened 15 720 citations and included 65 studies in the review. Exposed pregnant people had a significantly increased risk of SGA relative risk (RR) 1.33 (95% CI 1.18 to 1.50, I2 74%), LBW RR 1.54 (95% CI 1.33 to 1.77, I2 67%), and decreased birth weight with a mean difference (MD) of −118.87 (95% CI −161.03 to −76.71, I2 42%) g. A non‐significant risk change in birth height and head circumference was observed. In subgroup analysis, ASM polytherapy, within epilepsy and ASM class analysis were also associated with an increased risk of SGA and LBW. Conclusions: This meta‐analysis demonstrates that pregnant people exposed to ASMs have a significantly increased risk of adverse fetal growth outcomes including SGA and LBW and decreased birth weight compared to unexposed pregnant people. Polytherapy was associated with higher risks compared to monotherapy. Additional studies are warranted on specific ASM risks. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events : multi-database retrospective cohort study

Author

CanadianNetworkforObservationalDrugEffectStudies(CNODES)Investigators, Filion, Kristian B, Lix, Lisa M, Yu, Oriana HY, Dell’Aniello, Sophie, Douros, Antonios, Shah, Baiju R, St-Jean, Audray, Fisher, Anat, Tremblay, Eric, Bugden, Shawn C, Alessi-Severini, Silvia, Ronksley, Paul E, Hu, Nianping, Dormuth, Colin R, Ernst, Pierre, and Suissa, Samy

Published
2020

15. Prenatal antibiotic exposure and risk of attention-deficit/hyperactivity disorder: a population-based cohort study

Author

Hamad, Amani F., Alessi-Severini, Silvia, Mahmud, Salaheddin, and Brownell, Marni

Subjects
Microbiota (Symbiotic organisms), Attention deficit hyperactivity disorder, Antibiotics, Pregnant women, Databases, Future predictions, Children, Health
Abstract

BACKGROUND: Abnormal microbiota composition induced by prenatal exposure to antibiotics has been proposed as a potential contributor to the development of attention-deficit/hyperactivity disorder (ADHD). We examined the association between prenatal antibiotic exposure and risk of ADHD. METHODS: We conducted a population-based retrospective cohort study of children born in Manitoba, Canada, between 1998 and 2017 and their mothers. We defined exposure as the mother having filled 1 or more antibiotic prescriptions during pregnancy. The outcome was diagnosis of ADHD in the offspring, as identified in administrative databases. We estimated hazard ratios (HRs) using Cox proportional hazards regression in the overall cohort, in a separate cohort matched on high-dimensional propensity scores and in a sibling cohort. RESULTS: In the overall cohort, consisting of 187 605 children, prenatal antibiotic dispensation was associated with increased risk of ADHD (HR 1.22, 95% confidence interval [CI] 1.18-1.26). Similar results were observed in the matched cohort of 129 674 children (HR 1.20, 95% CI 1.15-1.24) but not in the sibling cohort (HR 1.06, 95% CI 0.99-1.13). Two negative-control analyses indicated a positive association with ADHD despite the lack of a reasonable biological mechanism, which suggested that the observed association between prenatal antibiotic dispensation and risk of ADHD was likely due to confounding. INTERPRETATION: In our study, prenatal antibiotic exposure was not associated with increased risk of ADHD in children. Although the risk was higher in the overall and matched cohorts, it was likely overestimated because of unmeasured confounding. Future studies are warranted to examine other factors affecting microbiota composition in association with risk of ADHD., Attention-deficit/hyperactivity disorder (ADHD) is a neuro-developmental disorder (1,2) that is associated with many long-term adverse health and social outcomes, such as comorbid depression and anxiety, drug abuse, motor vehicle collisions [...]

Published
2020
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16. Antiseizure Medication Use During Pregnancy and Neonatal Growth Outcomes: A Systematic Review and Meta‐Analysis

Author

Lavu, Alekhya, primary, Vaccaro, Christine, additional, Zusman, Enav, additional, Aboulatta, Laila, additional, Aloud, Basma, additional, Alessi‐Severini, Silvia, additional, Haidar, Lara, additional, Peymani, Payam, additional, Ng, Marcus C., additional, Ruth, Chelsea, additional, Falk, Jamison, additional, Desrochers, Brianne, additional, Valencia, Eunice, additional, Shouman, Walid, additional, Rabbani, Rasheda, additional, and Eltonsy, Sherif, additional

Published
2023
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19. Preterm birth and stillbirth rates associated with socioeconomic disparities during COVID-19 pandemic: a population-based cross-sectional study

Author

Aboulatta, Laila, primary, Kowalec, Kaarina, additional, Leong, Christine, additional, Delaney, Joseph A, additional, Falk, Jamie, additional, Alessi-Severini, Silvia, additional, Chateau, Dan, additional, Tan, Qier, additional, Kearns, Katherine, additional, Raimondi, Christina, additional, Vaccaro, Christine, additional, Lavu, Alekhya, additional, Haidar, Lara, additional, Peymani, Payam, additional, and Eltonsy, Sherif, additional

Published
2023
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27. COVID-19 pandemic impact on preterm birth and stillbirth rates associated with socioeconomic disparities: A quasi-experimental study

Author

Aboulatta, Laila, primary, Kowalec, Kaarina, additional, Leong, Christine, additional, Delaney, Joseph, additional, Falk, Jamie, additional, Alessi-Severini, Silvia, additional, Chateau, Dan, additional, Tan, Qier, additional, Kearns, Katherine, additional, Raimondi, Christina, additional, Lavu, Alekhya, additional, Haidar, Lara, additional, Vaccaro, Christine, additional, and Eltonsy, Sherif, additional

Published
2022
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29. Psychotropic Medication Use Before and During COVID-19: A Population-Wide Study

Author

Leong, Christine, primary, Kowalec, Kaarina, additional, Eltonsy, Sherif, additional, Bolton, James M., additional, Enns, Murray W., additional, Tan, Qier, additional, Yogendran, Marina, additional, Chateau, Dan, additional, Delaney, Joseph A., additional, Sareen, Jitender, additional, Falk, Jamison, additional, Spiwak, Rae, additional, Logsetty, Sarvesh, additional, and Alessi-Severini, Silvia, additional

Published
2022
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34. Additional file 1 of Validity of an algorithm to identify cardiovascular deaths from administrative health records: a multi-database population-based cohort study

Author

Lix, Lisa M., Sobhan, Shamsia, St-Jean, Audray, Daigle, Jean-Marc, Fisher, Anat, Yu, Oriana H. Y., Dell’Aniello, Sophie, Hu, Nianping, Bugden, Shawn C., Shah, Baiju R., Ronksley, Paul E., Alessi-Severini, Silvia, Douros, Antonios, Ernst, Pierre, and Filion, Kristian B.

Abstract

Additional file 1. Validity estimates for a cardiovascular mortality algorithm applied to administrative health records stratified by sex and age group. This file contains estimates of sensitivity, specificity, positive predictive value, and negative predictive value stratified by sex and age group (

Published
2021
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37. Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study

Author

Filion, Kristian B, primary, Lix, Lisa M, additional, Yu, Oriana HY, additional, Dell’Aniello, Sophie, additional, Douros, Antonios, additional, Shah, Baiju R, additional, St-Jean, Audray, additional, Fisher, Anat, additional, Tremblay, Eric, additional, Bugden, Shawn C, additional, Alessi-Severini, Silvia, additional, Ronksley, Paul E, additional, Hu, Nianping, additional, Dormuth, Colin R, additional, Ernst, Pierre, additional, and Suissa, Samy, additional

Published
2020
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38. Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Diabetic Ketoacidosis

Author

Douros, Antonios, primary, Lix, Lisa M., additional, Fralick, Michael, additional, Dell'Aniello, Sophie, additional, Shah, Baiju R., additional, Ronksley, Paul E., additional, Tremblay, Éric, additional, Hu, Nianping, additional, Alessi-Severini, Silvia, additional, Fisher, Anat, additional, Bugden, Shawn C., additional, Ernst, Pierre, additional, and Filion, Kristian B., additional

Published
2020
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40. Sodium Glucose Co-transporter-2 Inhibitors and the Risk of Below-knee Amputation: a Multicenter Observational Study

Author

Yu, Oriana Hoi Yun, primary, Dell’Aniello, Sophie, primary, Shah, Baiju R., primary, Brunetti, Vanessa C., primary, Daigle, Jean-Marc, primary, Fralick, Michael, primary, Douros, Antonios, primary, Hu, Nianping, primary, Alessi-Severini, Silvia, primary, Fisher, Anat, primary, Bugden, Shawn C., primary, Ronksley, Paul E., primary, Filion, Kristian B., primary, Ernst, Pierre, primary, and Lix, Lisa M., primary

Published
2020
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44. Methocarbamol

Author

Alessi-Severini, Silvia, primary, Jamali, Fakhreddin, additional, Coutts, Ronald T., additional, and Pasutto, Franco M., additional

Published
1994
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48. Developing key performance indicators for prescription medication systems

Author

Spackman, Eldon, primary, Clement, Fiona, additional, Allan, G. Michael, additional, Bell, Chaim M., additional, Bjerre, Lise M., additional, Blackburn, Dave F., additional, Blais, Régis, additional, Hazlewood, Glen, additional, Klarenbach, Scott, additional, Nicolle, Lindsay E., additional, Persaud, Nav, additional, Alessi-Severini, Silvia, additional, Tierney, Mike, additional, Wijeysundera, Harindra C., additional, and Manns, Braden, additional

Published
2019
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