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3. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Aguglia, Eugenio, Aguglia, Andrea, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Barbato, Angelo, Barbui, Corrado, Bartoli, Francesco, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callegari, Camilla, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandro, Carbone, Elvira, Carosielli, Doriana, Carrà, Giuseppe, Cartabia, Massimo, Caselli, Ivano, Cavaleri, Daniele, Cavallotti, Simone, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, D'Agostino, Armando, D'Avanzo, Barbara, De Fazio, Pasquale, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Gari, Matteo, Gastaldon, Chiara, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Ielmini, Marta, Ingrosso, Gianmarco, Isella, Celeste, Lax, Annamaria, Mammarella, Silvia, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Monti, Igor, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Ostuzzi, Giovanni, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Rodolico, Alessandro, Romito, Samantha, Ronchi, Barbara, Roncone, Rita, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sterzi, Enrico, Sturiale, Serena, Tambelli, Antonio, Tettamanti, Mauro, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, Zerbinati, Luigi, Canozzi, Andrea, Carbone, Elvira Anna, Caruso, Rosangela, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, de Filippis, Renato, Martinotti, Giovanni, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, and Amaddeo, Francesco

Published
2024
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4. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Ostuzzi, Giovanni, primary, Gastaldon, Chiara, additional, Tettamanti, Mauro, additional, Cartabia, Massimo, additional, Monti, Igor, additional, Aguglia, Andrea, additional, Aguglia, Eugenio, additional, Bartoli, Francesco, additional, Callegari, Camilla, additional, Canozzi, Andrea, additional, Carbone, Elvira Anna, additional, Carrà, Giuseppe, additional, Caruso, Rosangela, additional, Cavallotti, Simone, additional, Chiappini, Stefania, additional, Colasante, Fabrizio, additional, Compri, Beatrice, additional, D'Agostino, Armando, additional, De Fazio, Pasquale, additional, de Filippis, Renato, additional, Gari, Matteo, additional, Ielmini, Marta, additional, Ingrosso, Gianmarco, additional, Mammarella, Silvia, additional, Martinotti, Giovanni, additional, Rodolico, Alessandro, additional, Roncone, Rita, additional, Sterzi, Enrico, additional, Tarsitani, Lorenzo, additional, Tiberto, Elisa, additional, Todini, Liliana, additional, Amaddeo, Francesco, additional, D'Avanzo, Barbara, additional, Barbato, Angelo, additional, Barbui, Corrado, additional, Alessi, Maria Chiara, additional, Avincola, Gabriele, additional, Bachi, Bianca, additional, Bernasconi, Gianna, additional, Birgillito, Andrea, additional, Bisso, Emanuele, additional, Bonora, Stefano, additional, Calabrese, Angela, additional, Callovini, Tommaso, additional, Canestro, Aurelia, additional, Canonico, Salvo, additional, Capogrosso, Chiara Alessandro, additional, Carbone, Elvira, additional, Carosielli, Doriana, additional, Caselli, Ivano, additional, Cavaleri, Daniele, additional, Cavallotto, Clara, additional, Cesca, Marco, additional, Chiarenza, Cecilia, additional, Cioni, Riccardo Matteo, additional, Coloccini, Sara, additional, Cruciata, Marco, additional, Cumerlato, Claudia, additional, De Filippis, Renato, additional, De Palma, Manuela, additional, Del Vecchio, Sasha, additional, Della Rocca, Bianca, additional, Di Natale, Chiara, additional, D'Onofrio, Ettore, additional, Espa, Irene, additional, Fior, Giulia, additional, Gancitano, Marta, additional, Giordano, Barbara, additional, Giusti, Laura, additional, Grassi, Luigi, additional, Guzzi, Pierluca, additional, Isella, Celeste, additional, Lax, Annamaria, additional, Marano, Leonardo, additional, Marconi, Federico, additional, Marella, Marco, additional, Metelli, Alessia, additional, Michencig, Giulia, additional, Miuli, Andrea, additional, Moncada, Alessandro, additional, Morello, Pietro, additional, Moretti, Federico, additional, Morreale, Marco, additional, Mosca, Alessio, additional, Nasti, Christian, additional, Nosé, Michela, additional, Ogheri, Filippo, additional, Oresti, Margherita, additional, Ornaghi, Alessandra, additional, Ostuzzi, Giovanni, additional, Palpella, Dario, additional, Pancheri, Corinna, additional, Papola, Davide, additional, Passeri, Silvia, additional, Pettorusso, Mauro, additional, Piacenti, Susanna, additional, Pinucci, Irene, additional, Pugliese, Valentina, additional, Purgato, Marianna, additional, Rania, Marianna, additional, Robbi, Federica, additional, Romito, Samantha, additional, Ronchi, Barbara, additional, Roselli, Valentina, additional, Segura-Garcia, Cristina, additional, Signorelli, Maria Salvina, additional, Simonelli, Gabriele, additional, Sociali, Antonella, additional, Sturiale, Serena, additional, Tambelli, Antonio, additional, Todesco, Beatrice, additional, Trabucco, Alice, additional, Turrini, Giulia, additional, Villa, Veronica, additional, Wiedenmann, Federico, additional, Zambuto, Luca, additional, Zanini, Elisa, additional, Zannini, Chiara, additional, and Zerbinati, Luigi, additional

Published
2024
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7. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, Zerbinati, Luigi, Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, and Zerbinati, Luigi

Abstract

Background: Major depressive disorder (MDD) is prevalent and disabling among older adults. Standing on its tolerability profile, vortioxetine might be a promising alternative to selective serotonin reuptake inhibitors (SSRIs) in such a vulnerable population. Methods: We conducted a randomised, assessor- and statistician-blinded, superiority trial including older adults with MDD. The study was conducted between 02/02/2019 and 02/22/2023 in 11 Italian Psychiatric Services. Participants were randomised to vortioxetine or one of the SSRIs, selected according to common practice. Treatment discontinuation due to adverse events after six months was the primary outcome, for which we aimed to detect a 12% difference in favour of vortioxetine. The study was registered in the online repository clinicaltrials.gov (NCT03779789). Findings: The intention-to-treat population included 179 individuals randomised to vortioxetine and 178 to SSRIs. Mean age was 73.7 years (standard deviation 6.1), and 264 participants (69%) were female. Of those on vortioxetine, 78 (44%) discontinued the treatment due to adverse events at six months, compared to 59 (33%) of those on SSRIs (odds ratio 1.56; 95% confidence interval 1.01–2.39). Adjusted and per-protocol analyses confirmed point estimates in favour of SSRIs, but without a significant difference. With the exception of the unadjusted survival analysis showing SSRIs to outperform vortioxetine, secondary outcomes provided results consistent with a lack of substantial safety and tolerability differences between the two arms. Overall, no significant differences emerged in terms of response rates, depressive symptoms and quality of life, while SSRIs outperformed vortioxetine in terms of cognitive performance. Interpretation: As opposed to what was previously hypothesised, vortioxetine did not show a better tolerability profile compared to SSRIs in older adults with MDD in this study. Additionally, hypothetical advantages of vortioxetine on depress

Published
2024

10. Tolerability and efficacy of vortioxetine versus SSRIs in elderly with major depression. Study protocol of the VESPA study: a pragmatic, multicentre, open-label, parallel-group, superiority, randomized trial

Author

Ostuzzi, Giovanni, Gastaldon, Chiara, Barbato, Angelo, D’Avanzo, Barbara, Tettamanti, Mauro, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Alessi, Maria Chiara, Amore, Mario, Bartoli, Francesco, Biondi, Massimo, Bortolaso, Paola, Callegari, Camilla, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Crocamo, Cristina, D’Agostino, Armando, De Fazio, Pasquale, Di Natale, Chiara, Giusti, Laura, Grassi, Luigi, Martinotti, Giovanni, Nosé, Michela, Papola, Davide, Purgato, Marianna, Rodolico, Alessandro, Roncone, Rita, Tarsitani, Lorenzo, Turrini, Giulia, Zanini, Elisa, Amaddeo, Francesco, Ruggeri, Mirella, and Barbui, Corrado

Published
2020
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13. High-Risk Gaming Is Associated with Frequent Substance Use: An Exploratory Survey among Young Adults

Author

Di Carlo, Francesco, primary, Verrastro, Valeria, additional, Alessi, Maria Chiara, additional, Sociali, Antonella, additional, Altomare, Arianna Ida, additional, Di Natale, Chiara, additional, Stigliano, Gianfranco, additional, Miuli, Andrea, additional, Lalli, Aliseo, additional, Di Petta, Gilberto, additional, Chiappini, Stefania, additional, Pettorruso, Mauro, additional, Bowden-Jones, Henrietta, additional, Griffiths, Mark D, additional, and Martinotti, Giovanni, additional

Published
2023
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16. What role for cognitive remediation in the treatment of depressive symptoms? A superiority and noninferiority meta‐analysis for clinicians

Author

Sociali, Antonella, primary, Borgi, Marta, additional, Pettorruso, Mauro, additional, Di Carlo, Francesco, additional, Di Natale, Chiara, additional, Tambelli, Antonio, additional, Alessi, Maria C., additional, Ciavoni, Laura, additional, Mosca, Alessio, additional, Miuli, Andrea, additional, Sensi, Stefano L., additional, Martinotti, Giovanni, additional, Zoratto, Francesca, additional, and Di Giannantonio, Massimo, additional

Published
2022
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18. Craving variations in patients with substance use disorder and gambling during COVID-19 lockdown: The Italian experience

Author

Alessi, Maria Chiara, primary, Martinotti, Giovanni, additional, De Berardis, Domenico, additional, Sociali, Antonella, additional, Di Natale, Chiara, additional, Sepede, Gianna, additional, Cheffo, Daniela Pia Rosaria, additional, Monti, Laura, additional, Casella, Pietro, additional, Pettorruso, Mauro, additional, Sensi, Stefano, additional, and Di Giannantonio, Massimo, additional

Published
2022
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20. Use and knowledge of novel synthetic opioids: An Italian survey.

Author

Stigliano, Gianfranco, Miuli, Andrea, Vizziello, Alessandra, Altomare, Arianna Ida, Lalli, Aliseo, Alessi, Maria Chiara, Sociali, Antonella, Rucco, Annarita, Vannini, Chiara, Martinotti, Giovanni, and di Giannantonio, Massimo

Subjects
NARCOTICS, RISK-taking behavior, SUBSTANCE abuse, SCIENTIFIC observation, RESEARCH methodology, CROSS-sectional method, DRUG abuse, FENTANYL, SYNTHETIC drugs, HEALTH literacy, SURVEYS, QUESTIONNAIRES, DESCRIPTIVE statistics, SOCIODEMOGRAPHIC factors, PUBLIC opinion
Abstract

The recreational use of novel synthetic opioids (NSOs) is increasing, especially among the youngest part of the population. We conducted a naturalistic observational survey. The main outcome was to assess the use and the knowledge of NSOs among the youngest population in Italy. A sociodemographic questionnaire was also administrated. Nine hundred twenty questionnaires were completed. Fentanyl was the most used NSO (1.63% of the subjects). In all, 14.3% of the sample revealed awareness of NSOs. Although the diffusion in Italy is small, the large knowledge of NSOs requires future monitoring of this phenomenon. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Additional file 1 of Tolerability and efficacy of vortioxetine versus SSRIs in elderly with major depression. Study protocol of the VESPA study: a pragmatic, multicentre, open-label, parallel-group, superiority, randomized trial

Author

Ostuzzi, Giovanni, Gastaldon, Chiara, Barbato, Angelo, D’Avanzo, Barbara, Tettamanti, Mauro, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Alessi, Maria Chiara, Amore, Mario, Bartoli, Francesco, Biondi, Massimo, Bortolaso, Paola, Callegari, Camilla, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Crocamo, Cristina, D’Agostino, Armando, Fazio, Pasquale De, Natale, Chiara Di, Giusti, Laura, Grassi, Luigi, Martinotti, Giovanni, Nosé, Michela, Papola, Davide, Purgato, Marianna, Rodolico, Alessandro, Roncone, Rita, Tarsitani, Lorenzo, Turrini, Giulia, Zanini, Elisa, Amaddeo, Francesco, Ruggeri, Mirella, and Barbui, Corrado

Abstract

Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.

Published
2020
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22. Use and knowledge of novel synthetic opioids: An Italian survey

Author

Stigliano, Gianfranco, primary, Miuli, Andrea, additional, Vizziello, Alessandra, additional, Altomare, Arianna Ida, additional, Lalli, Aliseo, additional, Alessi, Maria Chiara, additional, Sociali, Antonella, additional, Rucco, Annarita, additional, Vannini, Chiara, additional, Martinotti, Giovanni, additional, and di Giannantonio, Massimo, additional

Published
2020
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23. Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy

Author

Martinotti, Giovanni, primary, Alessi, Maria Chiara, additional, Di Natale, Chiara, additional, Sociali, Antonella, additional, Ceci, Franca, additional, Lucidi, Lorenza, additional, Picutti, Elena, additional, Di Carlo, Francesco, additional, Corbo, Mariangela, additional, Vellante, Federica, additional, Fiori, Federica, additional, Tourjansky, Gaia, additional, Catalano, Gabriella, additional, Carenti, Maria Luisa, additional, Incerti, Chiara Concetta, additional, Bartoletti, Luigi, additional, Barlati, Stefano, additional, Romeo, Vincenzo Maria, additional, Verrastro, Valeria, additional, De Giorgio, Fabio, additional, Valchera, Alessandro, additional, Sepede, Gianna, additional, Casella, Pietro, additional, Pettorruso, Mauro, additional, and di Giannantonio, Massimo, additional

Published
2020
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24. Tolerability and Efficacy of Vortioxetine Versus SSRIs in Elderly With Major Depression. Study Protocol of the VESPA Study: A Pragmatic, Multicentre, Open-Label, Parallel-Group, Superiority, Randomized Trial

Author

Ostuzzi, Giovanni, primary, Gastaldon, Chiara, additional, Barbato, Angelo, additional, D’Avanzo, Barbara, additional, Tettamanti, Mauro, additional, Monti, Igor, additional, Aguglia, Andrea, additional, Aguglia, Eugenio, additional, Alessi, Maria Chiara, additional, Amore, Mario, additional, Bartoli, Francesco, additional, Biondi, Massimo, additional, Bortolaso, Paola, additional, Callegari, Camilla, additional, Carrà, Giuseppe, additional, Caruso, Rosangela, additional, Cavallotti, Simone, additional, Crocamo, Cristina, additional, D’Agostino, Armando, additional, De Fazio, Pasquale, additional, Natale, Chiara Di, additional, Giusti, Laura, additional, Grassi, Luigi, additional, Martinotti, Giovanni, additional, Nosé, Michela, additional, Papola, Davide, additional, Purgato, Marianna, additional, Rodolico, Alessandro, additional, Roncone, Rita, additional, Tarsitani, Lorenzo, additional, Turrini, Giulia, additional, Zanini, Elisa, additional, Amaddeo, Francesco, additional, Ruggeri, Mirella, additional, and Barbui, Corrado, additional

Published
2020
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26. Tolerability and Efficacy of Vortioxetine Versus SSRIs in Elderly with Major Depression. Study Protocol of the Vespa Study: A Pragmatic, Multicentre, Open-Label, Parrallel-Group, Superiority, Randomized Trial

Author

Ostuzzi, Giovanni, primary, Gastaldon, Chiara, additional, Barbato, Angelo, additional, D’Avanzo, Barbara, additional, Tettamanti, Mauro, additional, Monti, Igor, additional, Aguglia, Andrea, additional, Aguglia, Eugenio, additional, Alessi, Maria Chiara, additional, Amore, Mario, additional, Bartoli, Francesco, additional, Biondi, Massimo, additional, Bortolaso, Paola, additional, Callegari, Camilla, additional, Carrà, Giuseppe, additional, Caruso, Rosangela, additional, Cavallotti, Simone, additional, Crocamo, Cristina, additional, D’Agostino, Armando, additional, De Fazio, Pasquale, additional, Natale, Chiara Di, additional, Giusti, Laura, additional, Grassi, Luigi, additional, Martinotti, Giovanni, additional, Nosé, Michela, additional, Papola, Davide, additional, Purgato, Marianna, additional, Rodolico, Alessandro, additional, Roncone, Rita, additional, Tarsitani, Lorenzo, additional, Turrini, Giulia, additional, Zanini, Elisa, additional, Amaddeo, Francesco, additional, Ruggeri, Mirella, additional, and Barbui, Corrado, additional

Published
2019
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31. Motivations for attempting suicide in mid- and late-life.

Author

Alessi, Maria, Szanto, Katalin, and Dombrovski, Alexandre

Abstract

ABSTRACTObjectives:To understand pathways to suicide by investigating the association between personality and suicidal motivations in mid- and late-life attempts.Design: In a two-study approach, we measured different components of suicidal motivations using an existing self-report investigating reasons for suicide and a semi-qualitative assessment of motivational states preceding attempts.Setting: Inpatient and outpatient psychiatric services in Pittsburgh, PA.Participants: Study 1 (n = 50, mean age at attempt = 60.4) was a smaller sample of suicide attempters included in Study 2 (n = 69, mean age at attempt = 60.9). Non-psychiatric healthy controls (n = 50, mean age = 67.1) were used as benchmarks for dispositional measures.Measurements: Motives for suicide were measured by the Reasons for Attempting Suicide Questionnaire (RASQ). Participants' written descriptions of the thoughts and feelings preceding their attempt captured motivational states. Measures of personality for both studies included assessments of impulsivity, five-factor model, interpersonal dysfunction, and borderline traits.Results: In study 1, escape/self-punishment motives on the RASQ were associated with multiple attempts and borderline pathology, while interpersonal motives were less frequently endorsed and associated with poorly planned attempts. In study 2, experiences of defeat (i.e. powerlessness, poor coping to threats to autonomy/status) were more frequently endorsed by men and associated with disagreeableness.Conclusions: Study 1 revealed that attempters high in dysfunctional psychopathology were more likely to report self-oriented escape motives for suicide, while study 2 identified a putative pathway to suicide in men involving antagonism and the experience of defeat. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Executive functions in obsessive–compulsive disorder: An activation likelihood estimate meta-analysis of fMRI studies

Author

Del Casale, Antonio, primary, Rapinesi, Chiara, additional, Kotzalidis, Georgios D., additional, De Rossi, Pietro, additional, Curto, Martina, additional, Janiri, Delfina, additional, Criscuolo, Silvia, additional, Alessi, Maria Chiara, additional, Ferri, Vittoria Rachele, additional, De Giorgi, Riccardo, additional, Sani, Gabriele, additional, Ferracuti, Stefano, additional, Girardi, Paolo, additional, and Brugnoli, Roberto, additional

Published
2015
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34. Effectiveness of long-acting risperidone in a patient with comorbid intellectual disability, catatonic schizophrenia, and oneiroid syndrome

Author

Serata, Daniele, primary, Rapinesi, Chiara, additional, Demetrios Kotzalidis, Georgios, additional, Chiara Alessi, Maria, additional, Janiri, Delfina, additional, Claudia Massolo, Anna, additional, Rachele Ferri, Vittoria, additional, Criscuolo, Silvia, additional, Callovini, Gemma, additional, Angeletti, Gloria, additional, Girardi, Paolo, additional, and Del Casale, Antonio, additional

Published
2015
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35. Functional Neuroimaging in Psychopathy

Author

Del Casale, Antonio, primary, Kotzalidis, Georgios D., additional, Rapinesi, Chiara, additional, Di Pietro, Simone, additional, Alessi, Maria Chiara, additional, Di Cesare, Gianluigi, additional, Criscuolo, Silvia, additional, De Rossi, Pietro, additional, Tatarelli, Roberto, additional, Girardi, Paolo, additional, and Ferracuti, Stefano, additional

Published
2015
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36. Avaliação da hidrólise alcalina da gordura sobre a biodegradação anaeróbia de soro de queijo

Author

Alessi, Maria Clara Machado, Cammarota, Magali Christe, Ribeiro, Eloízio Júlio, Coutinho Filho, Ubirajara, and Cardoso, Vicelma Luiz

Subjects
Biodegradação anaeróbia, Alkaline hydrolysis, Óleos e gorduras, Fat, Soro de leite, Bioreatores, ENGENHARIAS::ENGENHARIA QUIMICA [CNPQ], Soro do leite, Cheese Whey, Hdrólise alcalina, Anaerobic biodegradation, Gordura
Abstract

The cheese whey represents the most important reject of the industry of dairy products, mainly due to its expressive generated volume. The cheese whey is a problematic substrate under the environmental point of view, presenting high amounts of carbohydrates, proteins and fats, giving it a chemical demand of oxygen of approximately a hundred times larger than the one of the domestic waste. An alternative for its treatment would be the anaerobic fermentation, which reduces its pollutant impact, making possible even the recovery of the energy from the formed biogas. However, the low biodegradation rate of the fats in the cheese whey difficulties the anaerobic treatment, reducing the mass transfer, leading to biomass loss and to the collapse of the reactor. In this context, this work had as objective to evaluate the effect of the preliminary stage from the alkaline hydrolyses of the fats in the anaerobic biodegradation of the cheese whey. A complet experimental design, being considered as the independent variables factors as time and the concentration of NaOH indicated the best hydrolyses conditions as 0,1% of NaOH, reaction time at 15h in 35°C and 200 rpm. In the study of the biodegradability of the cheese whey was used as inoculum a sludge colleted in a anaerobic reactor from the effluents treatment of a food industry. The COD removal and the biogas production were monitored by time, in different concentrations of the cheese whey solution in the basal medium. The removal of COD and the biogas production were higher in the experiments with the previously hydrolyzed solutions, especially for larger concentrations of cheese whey. These results shows that the alkaline hydrolyzes may be an alternative in the biological treatment of effluents with high fat concentration. O soro de queijo representa o mais importante rejeito da indústria de laticínios, devido principalmente ao expressivo volume gerado. O soro é um substrato problemático sob o ponto de vista ambiental, pois apresenta elevados teores de carboidratos, proteínas e gorduras, que lhe conferem uma Demanda Química de Oxigênio cerca de cem vezes maior que a do esgoto doméstico. Uma alternativa de tratamento do mesmo seria a fermentação anaeróbia, através da qual se reduziria seu impacto poluidor, além de possibilitar a recuperação de energia do biogás formado. No entanto, a baixa taxa de biodegradação das gorduras presentes no soro dificulta o tratamento anaeróbio, reduzindo a transferência de massa, levando à perda de biomassa e até o colapso do reator. Neste contexto, o trabalho teve como objetivo avaliar o efeito de uma etapa preliminar de hidrólise alcalina das gorduras sobre a biodegradação anaeróbia do soro. Um planejamento experimental fatorial 32, considerando-se como variáveis independentes os fatores tempo e a concentração de NaOH indicou as melhores condições de hidrólise como sendo 0,1% de NaOH, tempo de reação de 15 h a 35°C e 200 rpm. No estudo da biodegradabilidade do soro foi empregado como inóculo um lodo coletado em um reator anaeróbio de tratamento de efluentes de uma indústria alimentícia. A remoção de DQO e a produção de biogás foram monitoradas ao longo do tempo, mediante diferentes concentrações da solução de soro no meio basal. A remoção de DQO e a produção de biogás foram mais elevadas nos experimentos com a solução previamente hidrolisada, especialmente para maiores teores de solução de soro. Estes resultados mostram que a hidrólise alcalina pode ser uma alternativa no tratamento biológico de efluentes com altos teores de gordura. Mestre em Engenharia Química

Published
2005

37. Executive functions in obsessive–compulsive disorder: An activation likelihood estimate meta-analysis of fMRI studies.

Author

Del Casale, Antonio, Rapinesi, Chiara, Kotzalidis, Georgios D., De Rossi, Pietro, Curto, Martina, Janiri, Delfina, Criscuolo, Silvia, Alessi, Maria Chiara, Ferri, Vittoria Rachele, De Giorgi, Riccardo, Sani, Gabriele, Ferracuti, Stefano, Girardi, Paolo, and Brugnoli, Roberto

Subjects
OBSESSIVE-compulsive disorder, FUNCTIONAL magnetic resonance imaging, META-analysis, CAUDATE nucleus, THALAMUS
Abstract

Objectives: To identify activation changes assessed in functional magnetic resonance imaging (fMRI) studies of obsessive–compulsive disorder (OCD) through Activation Likelihood Estimate meta-analysis. Methods: We included 28 peer-reviewed standard stereotactic space studies assessing adult OCD patients (OCDpts) vs. healthy controls (HCs) with fMRI during executive task performance. Results: In within-group analyses, HCs showed task-related activations in bilateral inferior frontal gyri, right middle frontal gyrus, right inferior parietal lobule, right claustrum, bilateral cingulate gyri, and left caudate body. OCDpts showed task-related left-sided activations in the superior, medial, and inferior frontal gyri, and thalamus, and bilateral activations in the middle frontal gyri, inferior parietal lobule, and insular cortices. Subtraction analysis showed increased left middle frontal gyrus activation in OCDpts. In between-groups analyses, OCDpts hypoactivated the right caudate body, left putamen, left ACC, and right medial and middle frontal gyri. Right caudate hypoactivation persisted also after applying Family‐wise error algorithms. Conclusions: This meta-analysis confirms that during executive functioning OCDpts show a functional deficit of the right caudate body, which could represent a major neural functional correlate of their illness. [ABSTRACT FROM AUTHOR]

Published
2016
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38. IL RUOLO DEL CENTRO DIURNO NELLA RIDUZIONE DEI RICOVERI.

Author

Di Cesare, Gianluigi, Criscuolo, Silvia, and Alessi, Maria Chiara

Abstract

Copyright of Psichiatria e Psicoterapia is the property of Giovanni Fioriti Editore and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016

42. Covid-19 temporally related multisystem inflammatory syndrome (MIS-C): una finestra precoce di opportunità terapeutica è una strategia vincente? COVID pediatrico di Palermo

Author

Salvatore Giordano, Maria Concetta Failla, Martina Gioacchina Campione, Lucia Siracusa, Luca Messina, Luca Alessi, Maria Cristina Maggio, and Salvatore Giordano, Maria Concetta Failla, Martina Gioacchina Campione, Lucia Siracusa, Luca Messina, Luca Alessi, Maria Cristina Maggio

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, MIS-C, Covid-19, IL-1, IL-6
Published
2021

43. Influence of Polymer Electrospun Nanofibers on Thermal Properties of Epoxy Resins

Author

Sabina Alessi, Maria Di Filippo, Clelia Dispenza, and Sabina Alessi, Maria Di Filippo, Clelia Dispenza

Subjects
electrospun nanofiber, lcsh:Computer engineering. Computer hardware, epoxy resins, lcsh:TP155-156, lcsh:TK7885-7895, lcsh:Chemical engineering
Abstract

Electrospinning of polymers has gained surging interest in the last decades due to its wide range of applications in different fields, such as sensors, electronic devices, separation systems, biomedical materials. Still there are only few reports on the use of these nanofibers as reinforcement in polymer composites. In this paper, solution electrospinning was employed to produce nanofibrous mats impregnating two epoxy resins to form “monolayer“ systems, with the aim to study the influence of the nanofibers on both the curing behaviour and the morphology of the resin systems. Three polymers were chosen for producing electrospun mats, a polysulfone (PSF), a polyamide Nylon 6,6 (Ny66) and a polyacrilonitrile (PAN). The nanofibrous mats were employed to produce mat/epoxy monolayers by soaking the mat in two different epoxy resin systems, one in lab-synthesized-high performance, and the other commercial-low performance. The results show a different extent of swelling of the electronspun mats, as derived by morphological analysis. The observation of the fractured surfaces also indicates the formation of several fracture planes or phase separation phenomena, suggesting the possibility of dissipation of fracture energy by the epoxy/mat nanocomposites. Additionally, for all resin/mat arrangements, thermal analysis indicates no significant interference of the mat with the cure reactions of the resins and only slight changes of the glass transition temperatures.

Published
2019

44. POLYMER ELECTROSPUN NANOFIBERS AS INTERLEAVES FOR ENANCHEMENT OF CFRP LAMINATES DELAMINATION RESISTANCE

Author

Sabina Alessi, Maria Di Filippo, Clelia Dispenza, and Sabina Alessi, Maria Di Filippo, Clelia Dispenza

Subjects
Elettrospinning, epoxy resins, carbon fiber composites, Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie
Abstract

Electrospinning process is a technique to produce nanoscale fibers that has evinced more interest in recent years due to its versatility and potential for applications in several applications. The mall size and the concomitant ultra-high specific surface area of electrospun nanofibers make them suitable for several applications, such as tissue engineering, biosensors, filtration and advanced polymer composites (1). In particular for carbon fiber reinforced polymers (CFRPs) the huge specific surface area of electrospun nanofibers results in very large interfacial area between nanofibers and polymer matrix and therefore leads to substantial improvement of fiber-matrix interfacial interactions (2). This method is a valid alternative to nanofiller dispersion in the polymer matrix when its viscosity is a great problem in the processing such as in the case of resin transfer molding . In this work electrospun polysulfone nanofibers were prepared by solution and the obtained non-woven mat was used as interleave of a model carbon fiber-epoxy composite laminate. The impact of the electrospun mat on the cure kinetics of the resin was investigated with DSC calorimetric analysis and the thermal behaviour of the produced composite was studied with DMTA. The morphological analysis of the fractured surfaces of the laminate was also performed, evidencing the partial loss of the the continuity of the nanofibrous mat due to the possible occurring of phase separation phenomena.

Published
2019

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