Author: "Alessandro Roberto Dodesini" - Searchworks@Jio Institute Digital Library Search Results

32 results on '"Alessandro Roberto Dodesini"'

1. Impact of a Complement Factor H Gene Variant on Renal Dysfunction, Cardiovascular Events, and Response to ACE Inhibitor Therapy in Type 2 Diabetes

Author: Elisabetta Valoti, Marina Noris, Annalisa Perna, Erica Rurali, Giulia Gherardi, Matteo Breno, Aneliya Parvanova Ilieva, Ilian Petrov Iliev, Antonio Bossi, Roberto Trevisan, Alessandro Roberto Dodesini, Silvia Ferrari, Nadia Stucchi, Ariela Benigni, Giuseppe Remuzzi, and Piero Ruggenenti
Subjects: diabetes, complement, factor H, ACE inhibitors, microalbuminuria, cardiovascular risk, Genetics, QH426-470
Abstract: Complement activation has been increasingly implicated in the pathogenesis of type 2 diabetes and its chronic complications. It is unknown whether complement factor H (CFH) genetic variants, which have been previously associated with complement-mediated organ damage likely due to inefficient complement modulation, influence the risk of renal and cardiovascular events and response to therapy with angiotensin-converting enzyme inhibitors (ACEi) in type 2 diabetic patients. Here, we have analyzed the c.2808G>T, (p.Glu936Asp) CFH polymorphism, which tags the H3 CFH haplotype associated to low plasma factor H levels and predisposing to atypical hemolytic uremic syndrome, in 1,158 type 2 diabetics prospectively followed in the Bergamo nephrologic complications of type 2 diabetes randomized, controlled clinical trial (BENEDICT) that evaluated the effect of the ACEi trandolapril on new onset microalbuminuria. At multivariable Cox analysis, the p.Glu936Asp polymorphism (Asp/Asp homozygotes, recessive model) was associated with increased risk of microalbuminuria [adjusted hazard ratio (HR) 3.25 (95% CI 1.46–7.24), P = 0.0038] and cardiovascular events [adjusted HR 2.68 (95% CI 1.23–5.87), P = 0.013]. The p.Glu936Asp genotype significantly interacted with ACEi therapy in predicting microalbuminuria. ACEi therapy was not nephroprotective in Asp/Asp homozygotes [adjusted HR 1.54 (0.18–13.07), P = 0.691 vs. non-ACEi-treated Asp/Asp patients], whereas it significantly reduced microalbuminuria events in Glu/Asp or Glu/Glu patients [adjusted HR 0.38 (0.24–0.60), P < 0.0001 vs. non-ACEi-treated Glu/Asp or Glu/Glu patients]. Among ACEi-treated patients, the risk of developing cardiovascular events was higher in Asp/Asp homozygotes than in Glu/Asp or Glu/Glu patients [adjusted HR 3.26 (1.29–8.28), P = 0.013]. Our results indicate that type 2 diabetic patients Asp/Asp homozygotes in the p.Glu936Asp CFH polymorphism are at increased risk of microalbuminuria and cardiovascular complications and may be less likely to benefit from ACEi therapy. Further studies are required to confirm our findings.
Published: 2019
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2. Switching to the Minimed™ 780G system achieves clinical targets for CGM in adults with type 1 diabetes regardless of previous insulin strategy and baseline glucose control

Author: Giuseppe Lepore, Alessandro Rossini, Rosalia Bellante, Anna Corsi, Cristiana Scaranna, Alessandro Roberto Dodesini, Roberto Trevisan, Lepore, G, Rossini, A, Bellante, R, Corsi, A, Scaranna, C, Dodesini, A, and Trevisan, R
Subjects: Adult, Blood Glucose, Male, Advanced hybrid closed-loop system, Glucose sensor, Continuous subcutaneous insulin infusion, Blood Glucose Self-Monitoring, Endocrinology, Diabetes and Metabolism, General Medicine, Middle Aged, Diabetes Mellitus, Type 1, Insulin Infusion Systems, Endocrinology, Internal Medicine, Insulin therapy, Humans, Hypoglycemic Agents, Insulin, Female, Insulin pump, Type 1 diabetes mellitu, Retrospective Studies
Abstract: Aims: Advanced hybrid closed-loop (AHCL) systems represent the latest introduction in the treatment of type 1 diabetes (T1DM). Randomized controlled trials and real-world evidence studies showed that AHCL systems are a safe and effective insulin management strategy. Aim of this retrospective, single-center, real-life study was to evaluate the effect on metabolic control, evaluated by continuous glucose monitoring (CGM) metrics, of the switch from four available insulin strategies to an AHCL system in adult patients with type 1 diabetes. Methods: A total of 102 patients with T1DM (mean age 42.1 ± 16.3 years, males/females 47/55, duration of diabetes 21.4 ± 13.3 years, BMI 24.4 ± 4.5 kg/m2, HbA1c 59.9 ± 9.6 mmol/mol or 7.6 ± 0.9%), treated with four different insulin therapies [multiple daily insulin (MDI) therapy, continuous subcutaneous insulin infusion (CSII), sensor-augmented pump (SAP) with predictive low-glucose suspend (PLGS), and hybrid closed loop (HCL) system] were evaluated before hand, two months and six months after switching to an AHCL (Minimed™ 780G system, Medtronic, Northridge, CA) system. Results: Two months after the switch, mean GCM metrics improved in all four treatment groups. Six months after the switch, the participants of all four groups achieved a mean GMI < 53 mmol/mol, TIR > 70%, TBR < 4%, and CV < 36%, which is recommended by the ADA Standard of Medical Care in Diabetes 2022, including the MDI group with worse baseline glycemic control. Conclusions: Switching to an AHCL leads to a rapid improvement in glycemic control lasting for up to six months independently of previous insulin treatment and baseline conditions.
Published: 2022

3. Real-World Insulin Treatment in Pregnant Women with Type 1 Diabetes Using an Advanced Hybrid Closed-Loop System

Author: Alessandro Roberto Dodesini, Nicolò Diego Borella, Giuseppe Lepore, Silvia Bonfadini, Anna Corsi, Cristiana Scaranna, Rosalia Bellante, Roberto Trevisan, Dodesini, A, Borella, N, Lepore, G, Corsi, A, Bonfadini, S, Bellante, R, Scaranna, C, and Trevisan, R
Subjects: Medical Laboratory Technology, Endocrinology, Endocrinology, Diabetes and Metabolism, Type 1 diabetes, Pregnancy, aHCL, CGM metrics
Published: 2023

4. An Experience of Insulin Basal Titration in Lombardy (Italy) during the Pandemic

Author: Olga Eugenia Disoteo, Alessandro Roberto Dodesini, Bruno Solerte, Paolo Desenzani, Paolo Erpoli, Roberto Manfrini, Laura Molteni, and Bossi Antonio Carlo
Published: 2022

5. Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study

Author: Marco Mirani, Riccardo Colombo, Ida Pastore, Rosalia Bellante, Francesca D'Addio, Angelo Corsico, Alessandro Roberto Dodesini, Cristiana Scaranna, Silvia Galliani, Sebastiano Bruno Solerte, Roberto Trevisan, Elisabetta Lovati, Giuseppe Lepore, Franco Folli, Emanuele Catena, Salvatore Endrio Oleandri, Marco Dell’Acqua, Antonio Rossi, Elio Ippolito, Francesca Geni, Antonio Di Sabatino, Carlo De Riva, Gian Vincenzo Zuccotti, Paolo Fiorina, Roberta Maria Fiorina, Reza Abdi, Massimo Galli, Joseph V. Bonventre, Stefano Rusconi, Solerte, S, D'Addio, F, Trevisan, R, Lovati, E, Rossi, A, Pastore, I, Acqua, M, Ippolito, E, Scaranna, C, Bellante, R, Galliani, S, Dodesini, A, Lepore, G, Geni, F, Fiorina, R, Catena, E, Corsico, A, Colombo, R, Mirani, M, Riva De, C, Oleandri, S, Abdi, R, Bonventre, J, Rusconi, S, Folli, F, Sabatino, A, Zuccotti, G, Galli, M, and Fiorina, P
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Coronaviru, Pneumonia, Viral, Population, 030209 endocrinology & metabolism, Type 2 diabetes, Dipeptidyl peptidase-4 inhibitor, Sitagliptin Phosphate, 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, 030212 general & internal medicine, education, Advanced and Specialized Nursing, education.field_of_study, Betacoronaviru, Pandemic, Emerging Therapies: Drugs and Regimens, SARS-CoV-2, Coronavirus Infection, business.industry, Hazard ratio, COVID-19, Retrospective cohort study, medicine.disease, Hospitalization, Italy, Diabetes Mellitus, Type 2, Sitagliptin, business, Human, medicine.drug
Abstract: OBJECTIVE Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population. RESEARCH DESIGN AND METHODS In a multicenter, case-control, retrospective, observational study, sitagliptin, an oral and highly selective dipeptidyl peptidase 4 inhibitor, was added to standard of care (e.g., insulin administration) at the time of hospitalization in patients with type 2 diabetes who were hospitalized with COVID-19. Every center also recruited at a 1:1 ratio untreated control subjects matched for age and sex. All patients had pneumonia and exhibited oxygen saturation RESULTS Of the 338 consecutive patients with type 2 diabetes and COVID-19 admitted in Northern Italy hospitals included in this study, 169 were on sitagliptin, while 169 were on standard of care. Treatment with sitagliptin at the time of hospitalization was associated with reduced mortality (18% vs. 37% of deceased patients; hazard ratio 0.44 [95% CI 0.29–0.66]; P = 0.0001), with an improvement in clinical outcomes (60% vs. 38% of improved patients; P = 0.0001) and with a greater number of hospital discharges (120 vs. 89 of discharged patients; P = 0.0008) compared with patients receiving standard of care, respectively. CONCLUSIONS In this multicenter, case-control, retrospective, observational study of patients with type 2 diabetes admitted to the hospital for COVID-19, sitagliptin treatment at the time of hospitalization was associated with reduced mortality and improved clinical outcomes as compared with standard-of-care treatment. The effects of sitagliptin in patients with type 2 diabetes and COVID-19 should be confirmed in an ongoing randomized, placebo-controlled trial.
Published: 2020

6. Switching from Suspend-Before-Low Insulin Pump Technology to a Hybrid Closed-Loop System Improves Glucose Control and Reduces Glucose Variability: A Retrospective Observational Case–Control Study

Author: Giuseppe Lepore, Anna Maria Corsi, Alessandro Roberto Dodesini, Roberto Trevisan, Cristiana Scaranna, Lepore, G, Scaranna, C, Corsi, A, Dodesini, A, and Trevisan, R
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Glucose control, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Glycemic Control, Low insulin, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, Hybrid closed-loop system, Predictive low glucose suspend, Sensor-augmented pump, Type 1 diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, 030212 general & internal medicine, Low glucose suspend, Retrospective Studies, business.industry, Blood Glucose Self-Monitoring, Case-control study, Middle Aged, medicine.disease, Hypoglycemia, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Treatment Outcome, Feature (computer vision), Case-Control Studies, Cardiology, Female, Observational study, business, Closed loop
Abstract: There are no data whether hybrid closed-loop (HCL) systems are superior to sensor-augmented pump (SAP) therapy with predictive low glucose suspend (PLGS) feature in improving glucose control. Aim of our study was to evaluate the effect on metabolic control and glucose variability of the switch from SAP therapy with PLGS to a HCL system in type 1 diabetic individuals. Forty adults with type 1 diabetes, who had been using SAP therapy with PLGS feature (Minimed 640G; Medtronic, Northridge, CA) for at least 12 months were evaluated in a 6-month case-control observational retrospective study. Twenty subjects who consecutively switched from Minimed 640G to a HCL system (Minimed 670G; Medtronic) (670G group) were compared with a control group consisting of 20 subjects who continued with the MiniMed 640G pump (640G group) matched for age, gender, and HbA1c. At the end of the study there was a significant reduction in average HbA1c levels (-4.9 ± 6.4 mmol/mol [-0.4% ± 0.6%], P < 0.01), sensor glucose concentrations (-15.4 ± 17.7 mg/dL, P < 0.005), coefficient of variation of sensor glucose concentrations (-3.8% ± 3.6%, P < 0.01), percentage time spent in both hyperglycemic range 181-250 mg/dL (-5.1% ± 4.5%, P < 0.05), and >250 mg/dL (-6.1% ± 6.9%, P < 0.05) in the 670G group, whereas they remained unchanged in the 640G group. Percentage of time spent in euglycemic range significantly increased (11.6% ± 8.3%, P < 0.005) only in the 670G group. There was no change in time spent in hypoglycemic range in both groups. In adults with type 1 diabetes, switching from a 640G to a 670G system significantly improved glucose control and reduced glucose variability, thus reaching in most cases the recommended targets for time spent in euglycemic and hyperglycemic ranges without increasing the risk of hypoglycemia.
Published: 2020

7. Resilience in pregnant women with pre-gestational diabetes during COVID-19 pandemic: the experience of the Papa Giovanni XXIII Hospital in Bergamo, Italy

Author: Maria Simonetta Spada, Alessandro Roberto Dodesini, Roberto Trevisan, Anna Caffi, Dodesini, A, Caffi, A, Spada, M, and Trevisan, R
Subjects: medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Endocrinology, Diabetes and Metabolism, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, diabetes, pregnancy, COVID-19, General Medicine, medicine.disease, Endocrinology, Family medicine, Diabetes mellitus, Pandemic, Internal Medicine, medicine, Psychology, Resilience (network), Letter to the Editor, Pre-Gestational Diabetes
Published: 2020

8. Pre-gestational diabetes during the COVID-19 pandemic in Bergamo, Italy

Author: Rosalia Bellante, Alessandro Roberto Dodesini, Roberto Trevisan, Silvia Galliani, Elena Ciriello, Dodesini, A, Galliani, S, Ciriello, E, Bellante, R, and Trevisan, R
Subjects: Pediatrics, medicine.medical_specialty, education.field_of_study, Coronavirus disease 2019 (COVID-19), business.industry, Population, Obstetrics and Gynecology, Outbreak, General Medicine, medicine.disease, Northern italy, Infectious disease (medical specialty), Diabetes mellitus, Obstetrics and Gynaecology, Pandemic, medicine, Bergamo, COVID-19, Pre-gestational diabetes, business, education, Pre-Gestational Diabetes
Abstract: The COVID-19 pandemic has caused the proliferation of a highly contagious and frequently fatal pneumonia around the world.[1] COVID-19 has severely affected Italy, and at the onset of this crisis, Bergamo, a city in northern Italy, regularly reported the highest number of cases in the country for many weeks. During outbreaks of infectious disease, pregnant women represent a high-risk population due to their increased susceptibility to infections, particularly when comorbidities such as pre-gestational diabetes (present in 0.5% of pregnant populations) are present.[2,3] Few data are available on pregnant women with pre-gestational diabetes during the COVID-19 pandemic.
Published: 2020

9. Contents Vol. 136, 2017

Author: Xuelian Ma, Gaetano Alfano, Maria Dolores Sanchez-Niño, David G. Warnock, Andreas Kjaer, Norberto Perico, Enrique Morales, Monica Cortinovis, Sergio Luis-Lima, Manuel Praga, Gianni Cappelli, Hans Pottel, Jia-qi He, Druckerei Stückle, Raul Fernandez-Prado, Niels Obel, Tatsuo Shimosawa, Bo Feldt-Rasmussen, Esteban Porrini, Maria Soledad Pizarro-Sánchez, Francesco Fontana, Jan Gerstoft, Conghui Wang, Ana Belen Sanz, Beatriz Fernandez-Fernandez, Li-juan Liang, Alessandro Roberto Dodesini, Pierre Delanaye, Roberto Trevisan, Zheng Wang, Alberto Ortiz, Esmeralda Castillo-Rodriguez, Mads Hornum, Beibei Liu, Xiangting Wang, Etienne Cavalier, Magnus Glindvad Ahlström, Catalina Martin-Cleary, Giuseppe Remuzzi, Qingyou Xu, and Richard J. Glassock
Subjects: Traditional medicine, business.industry, Medicine, business
Published: 2017

10. Continuous subcutaneous insulin infusion reduces maternal and neonatal risk in pregnant women with type 1 diabetes: An observational cohort study of 122 pregnancies

Author: Silvia Galliani, Giorgia Cavalli, Cristiana Scaranna, Anna Maria Corsi, Giuseppe Lepore, Mascia Albizzi, Rosalia Bellante, G. Mangili, Alessandro Roberto Dodesini, Elena Ciriello, Roberto Trevisan, Dodesini, A, Cavalli, G, Ciriello, E, Lepore, G, Corsi, A, Scaranna, C, Bellante, R, Albizzi, M, Galliani, S, Mangili, G, and Trevisan, R
Subjects: Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Infusions, Subcutaneous, Injections, Cohort Studies, Insulin Infusion Systems, Pregnancy, Diabetes mellitus, continuous subcutaneous insulin infusion, large for gestational age, multiple daily injections, pregnancy, type 1 diabetes, medicine, Humans, Hypoglycemic Agents, Insulin, Aged, Type 1 diabetes, business.industry, Obstetrics, Infant, Newborn, medicine.disease, Subcutaneous insulin, Diabetes Mellitus, Type 1, Treatment Outcome, Female, business, Cohort study
Published: 2020

11. 'MySweetGestation': A novel smartphone application for women with or at risk of diabetes during pregnancy

Author: C. Lencioni, Angela Napoli, Elisabetta Torlone, Camilla Festa, Laura Sciacca, Teresa Marcone, Ester Vitacolonna, Andrea Tumminia, Basilio Pintaudi, Elena Succurro, Marina Scavini, and Alessandro Roberto Dodesini
Subjects: Endocrinology, Diabetes and Metabolism, Population, Mobile health technology, 030209 endocrinology & metabolism, Smartphone application, Interactive Learning, 03 medical and health sciences, Interactive learning, Pregnancy with diabetes, Smartphone applications, Therapeutic education, 0302 clinical medicine, Endocrinology, Nursing, Pregnancy, Risk Factors, Diabetes mellitus, Internal Medicine, Humans, Medicine, 030212 general & internal medicine, education, mHealth, education.field_of_study, business.industry, Social impact, General Medicine, medicine.disease, Mobile Applications, Telemedicine, Diabetes, Gestational, Smartphone app, Female, business
Abstract: Mobile health (mHealth) applications (apps) have been recently introduced as an easily accessible tool for providing information to pregnant women with diabetes. Despite the growing number of apps on the topic "diabetes & pregnancy", a smartphone app offering comprehensive and individualized information to both women (before and during gestation) and their healthcare professionals was still missing. To overcome this lack, the Italian Diabetes and Pregnancy Study Group conceived and realized in 2016 a novel mobile app called "MySweetGestation". It is designed to be an interactive educational tool for both patients and physicians not expert in the field. Through an interactive way of learning, it provides validated information to the user, focusing on different area of interest: from prevention and risk factors for developing diabetes during pregnancy to treatment and follow-up strategies after gestation. Three years since its publication, MySweetGestation has been downloaded in different western and eastern countries worldwide, suggesting a widespread social impact. Easily accessible personalized information made available via mHealth technology may be of great importance to spread controlled information among the pregnant population. MySweetGestation, being an interactive educational device for both patients and healthcare professionals, may contribute to improve the management of pregnant women with diabetes.
Published: 2019

12. Review of general suggestions on physical activity to prevent and treat gestational and pre-existing diabetes during pregnancy and in postpartum

Author: Stefano Balducci, C. Lencioni, A. Bertolotto, Angela Napoli, T. Marcone, N. Di Biase, Ester Vitacolonna, Basilio Pintaudi, Andrea Tumminia, and Alessandro Roberto Dodesini
Subjects: Adult, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Pregnancy in Diabetics, Medicine (miscellaneous), 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, physical Activity, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pregnancy, Risk Factors, Diabetes mellitus, medicine, Childbirth, Humans, Healthy Lifestyle, Intensive care medicine, Exercise, Gestational diabetes, Nutrition and Dietetics, diabetes, business.industry, Postpartum Period, Pregnancy Outcome, nutritional and metabolic diseases, Protective Factors, medicine.disease, female genital diseases and pregnancy complications, Exercise Therapy, Clinical trial, Diabetes, Gestational, exercise training, Premature birth, Gestation, Anxiety, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: The aim of this review is to provide general suggestions on physical activity (PA) in pre-gestational and gestational diabetes mellitus (GDM) and encourage women to take part in safe and effective activities throughout pregnancy, in the absence of other contraindications. PA before and during pregnancy and in postpartum has many positive effects on the mother, as it could reduce the risk of GDM, excessive weight gain and lower back pain and also prevents, in the postpartum, diabetes mellitus. It may also reduce the duration of labour and complications at childbirth, fatigue, stress, anxiety and depression, thereby leading to an improved sense of wellbeing. Clinically, it is thought to help prevent preeclampsia and premature birth even though RCTs provide conflicting evidence with regard to the prevention of GDM. The main reason for this rests on the fact that the majority of clinical trials have not been able to replicate the preventive effect of PA on the onset of GDM, such as the different adherence of the patient to PA. Herein, we survey the literature regarding exercise and PA on GDM prevention and treatment as well as on clinical outcomes in pre-GDM in pregnancy. On the basis of the current literature, we also present a series of general recommendations and suggestions on PA and exercise training in pregnancy among both diabetic patients and those at risk for GDM.
Published: 2018

13. Effects of a low glycemic index high in fiber diet on blood glucose in women with gestational diabetes

Author: Veronica Donadoni, Luisa Patanè, Alessandro Roberto Dodesini, Roberto Trevisan, Ottavia Colombo, Silvia Galliani, Fiorenzo Cortinovis, Elena Ciriello, Dodesini, A, Donadoni, V, Ciriello, E, Colombo, O, Patane, L, Galliani, S, Cortinovis, F, and Trevisan, R
Subjects: Blood Glucose, medicine.medical_specialty, First line, 030209 endocrinology & metabolism, Low glycemic index, MELLITUS, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, Diabetes mellitus, Dietary Carbohydrates, Humans, Medicine, 030212 general & internal medicine, METAANALYSIS, Therapeutic strategy, business.industry, Obstetrics and Gynecology, medicine.disease, Diet, Gestational diabetes, Diabetes, Gestational, Endocrinology, Glycemic index, Diabetes Mellitus, Type 2, Glycemic Index, Pediatrics, Perinatology and Child Health, Gestation, Female, business
Abstract: Diet is the first line and the main therapeutic strategy in the treatment of gestational diabetes (GDM) with the primary objective to achieve normal blood glucose levels while promoting adequate ma...
Published: 2019

14. The Hyperfiltering Kidney in Diabetes

Author: Alessandro Roberto Dodesini, Roberto Trevisan, Trevisan, R, and Dodesini, A
Subjects: medicine.medical_specialty, Sodium, Hyperfiltration, Renal function, chemistry.chemical_element, 030209 endocrinology & metabolism, Disease, Diabetic nephropathy, 030204 cardiovascular system & hematology, Diabete, Kidney, 03 medical and health sciences, Intraglomerular pressure, 0302 clinical medicine, Sodium-Glucose Transporter 2, Internal medicine, Diabetes mellitus, medicine, Humans, Diabetic Nephropathies, MED/13 - ENDOCRINOLOGIA, Sodium-Glucose Transporter 2 Inhibitors, Reabsorption, business.industry, Sodium-Glucose Transporter 2 Inhibitor, medicine.disease, Renal glucose reabsorption, MED/14 - NEFROLOGIA, Endocrinology, medicine.anatomical_structure, chemistry, Diabetes Mellitus, Type 2, Diabetic Nephropathie, Disease Progression, business, Human, Glomerular Filtration Rate
Abstract: Hyperfiltering kidney is a typical feature of diabetes. Improvement observed with regard to glucose control and blood pressure control reduces the high glomerular filtration rate and may contribute to retard the appearance and the progression of diabetic renal disease. Although the mechanism of hyperfiltration is still unclear, there is mounting evidence that the increased reabsorption of glucose and sodium by sodium glucose transporter-2 (SGLT-2) is involved in this altered renal function. There is a possibility that SGLT-2 inhibition may correct hyperfiltration in diabetes, adding a new therapeutic approach to halt renal disease in patients with diabetes.
Published: 2017

15. Diabetes - clinical studies

Author: Simona Simone, Annalisa Perna, Nadia Rubis, Satsuki Sato, Honglang Xie, Pasquale Ditonno, Isamu Miyamori, Esteban Porrini, Masaaki Inaba, Miki Fujii, Tomoko Kimura, Tadashi Konoshita, Eiji Ishimura, Giuseppe Grandaliano, Michele Battaglia, Soffia Gudbjörnsdottir, Bjorn Zethelius, Giuseppe Remuzzi, Giovanni Pertosa, Yoshiteru Ohno, Yongchun Ge, Enrica Capitoni, Bogdan Ene-Iordache, Zhihong Liu, Elena Ranieri, Katsuhito Mori, Alessandro Roberto Dodesini, Flavio Gaspari, Ilian Petrov Iliev, Maria Svensson, Loreto Gesualdo, Giulia Gherardi, Akihiro Tsuda, Yasukazu Makino, Shigeyuki Wakahara, Bo Jin, Piero Ruggenenti, Björn Eliasson, Mitsuru Ichii, Shinya Nakatani, Antonio Vavallo, Marica Cariello, Mai Ichikawa, Jinhua Hou, Antonio Bossi, Aneliya Parvanova Ilieva, Shijun Li, Mingjun Shi, Nicola Motterlini, Giuseppe Sampietro, Jan Cederholm, Antonia Loverre, and Haitao Zhang
Subjects: Transplantation, medicine.medical_specialty, Nephrology, business.industry, Internal medicine, Diabetes mellitus, medicine, medicine.disease, business
Published: 2013

16. Level of implementation of guidelines on screening and diagnosis of gestational diabetes. a national survey

Author: Basilio Pintaudi, Angela Napoli, Alessandro Roberto Dodesini, Matteo Bonomo, Mariagrazia Dalfrà, Teresa Marcone, and Raffaella Fresa
Subjects: Adult, Blood Glucose, medicine.medical_specialty, Pediatrics, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Gestational Age, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Pregnancy, Risk Factors, Diabetes mellitus, Surveys and Questionnaires, Internal Medicine, medicine, Humans, Mass Screening, gestational diabetes, screening procedure, diagnostic test, In patient, 030212 general & internal medicine, Risk factor, Gynecology, Glucose tolerance test, medicine.diagnostic_test, business.industry, Diabetes in pregnancy, Health Plan Implementation, nutritional and metabolic diseases, Diagnostic test, General Medicine, Glucose Tolerance Test, medicine.disease, Gestational diabetes, Diabetes, Gestational, Italy, Practice Guidelines as Topic, Gestation, Female, business
Abstract: Aims To describe the degree of diffusion and acceptance of national guideline on screening and diagnosis of gestational diabetes (GDM) among Italian diabetes centers and to detect possible areas for benchmarking. Methods In 2013 the Italian Diabetes in Pregnancy Study Group structured a national survey, focused on GDM screening and diagnostic procedures, that was administered to diabetologists. Results Overall, 122 diabetologists of 122 different diabetes centers (21.7% territorial, 78.3% hospital/University) completed the questionnaire. All respondents declared to execute a 75 g-oral glucose tolerance test (OGTT) as diagnostic test. Almost one in five centers preferred a universal screening procedure, the others executing a selective risk factors-based screening. In patients at high risk for GDM the OGTT was performed at 16–18 weeks’ gestation in 84.0% of the cases; only 6.5% of respondents preferred to execute it as soon as possible; and 9.5% used to wait until 24–28 weeks’ gestation. In the case of fasting plasma glucose (FPG) ≥5.1 mmol/l (92 mg/dl), two third of respondents used to proceed with the execution of the complete diagnostic OGTT, the others considering sufficient the FPG value for the diagnosis. Conclusions Good level of reception of national recommendations was documented. The diagnostic procedure was generally accepted and applied. Some criticisms were specifically linked to the choice of universal or risk factor-based screening procedure, and to the right time for executing the OGTT in women at high risk.
Published: 2016

17. Continuous subcutaneous insulin infusion is more effective than multiple daily insulin injections in preventing albumin excretion rate increase in Type 1 diabetic patients

Author: Daniela Bruttomesso, I. Nosari, Matteo Bonomo, Giuseppe Lepore, R. Trevisan, S. Costa, Alessandro Roberto Dodesini, A. Corsi, and E. Meneghini
Subjects: Adult, Male, Insulin pump, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Urology, Renal function, Blood Pressure, Infusions, Subcutaneous, Young Adult, Insulin Infusion Systems, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Albuminuria, Humans, Insulin, Aged, Retrospective Studies, Aged, 80 and over, Type 1 diabetes, Proteinuria, business.industry, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Treatment Outcome, Female, Microalbuminuria, medicine.symptom, business, Glomerular Filtration Rate
Abstract: Aims To compare the effect of continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MDI) on albumin excretion rate (AER) in Type 1 diabetic patients. Methods In a 3-year multicentre retrospective observational study, 110 Type 1 diabetic patients treated with CSII were compared with 110 patients treated with MDI matched at baseline for age, sex, diabetes duration and HbA1c. At entry, 90 patients in each group had normal AER and 20 persistent microalbuminuria. AER, estimated glomerular filtration rate (eGFR), HbA1c, lipids and blood pressure were assessed. Results HbA1c was lower in the CSII than in the MDI group (8.1 ± 0.9 vs. 8.4 ± 1.3%; P
Published: 2009

18. Blood pressure and cholesterol levels in an Italian outpatient cohort of type 2 diabetic patients: Comparison with the general population

Author: Carmela Neotti, Giuseppe Lepore, Andrea Remuzzi, Alessandro Roberto Dodesini, Roberto Trevisan, and Bogdan Ene-Iordache
Subjects: education.field_of_study, medicine.medical_specialty, Nutrition and Dietetics, Cholesterol, business.industry, Endocrinology, Diabetes and Metabolism, Population, Settore ING-IND/34 - Bioingegneria Industriale, Medicine (miscellaneous), chemistry.chemical_compound, Blood pressure, chemistry, Internal medicine, Cohort, medicine, Cardiology and Cardiovascular Medicine, education, Intensive care medicine, business
Published: 2006

19. Measurable urinary albumin predicts cardiovascular risk among normoalbuminuric patients with type 2 diabetes

Author: Piero, Ruggenenti, Esteban, Porrini, Nicola, Motterlini, Annalisa, Perna, Aneliya Parvanova, Ilieva, Ilian Petrov, Iliev, Alessandro Roberto, Dodesini, Roberto, Trevisan, Antonio, Bossi, Giuseppe, Sampietro, Enrica, Capitoni, Flavio, Gaspari, Nadia, Rubis, Bogdan, Ene-Iordache, Giuseppe, Remuzzi, G C, Viberti, Ruggenenti, P, Porrini, E, Motterlini, N, Perna, A, Ilieva, A, Iliev, I, Dodesini, A, Trevisan, R, Bossi, A, Sampietro, G, Capitoni, E, Gaspari, F, Rubis, N, Ene-Iordache, B, and Remuzzi, G
Subjects: Male, medicine.medical_specialty, Cardiotonic Agents, Indoles, Longitudinal Studie, Angiotensin-Converting Enzyme Inhibitors, Type 2 diabetes, Risk Factors, Internal medicine, Cardiovascular Disease, medicine, Albuminuria, Humans, Clinical Epidemiology, Cardiotonic Agent, Myocardial infarction, Longitudinal Studies, Stroke, Aged, Diabetes Complication, business.industry, Risk Factor, Hazard ratio, Angiotensin-Converting Enzyme Inhibitor, General Medicine, Middle Aged, medicine.disease, Confidence interval, Surgery, Diabetes Mellitus, Type 2, Verapamil, Nephrology, Indole, Cardiovascular Diseases, Heart failure, Biological Marker, Cardiology, Female, medicine.symptom, business, Biomarkers, Human
Abstract: Micro- or macroalbuminuria is associated with increased cardiovascular risk factors among patients with type 2 diabetes, but whether albuminuria within the normal range predicts long-term cardiovascular risk is unknown. We evaluated the relationships between albuminuria and cardiovascular events in 1208 hypertensive, normoalbuminuric patients with type 2 diabetes from the BErgamo NEphrologic Diabetes Complication Trial (BENEDICT), all of whom received angiotensin-converting enzyme inhibitor (ACEI) therapy at the end of the trial and were followed for a median of 9.2 years. The main outcome was time to the first of fatal or nonfatal myocardial infarction; stroke; coronary, carotid, or peripheral artery revascularization; or hospitalization for heart failure. Overall, 189 (15.6%) of the patients experienced a main outcome event (2.14 events/100 patient-years); 24 events were fatal. Albuminuria independently predicted events (hazard ratio [HR], 1.05; 95% confidence interval [CI], 1.02-1.08). Second-degree polynomial multivariable analysis showed a continuous nonlinear relationship between albuminuria and events without thresholds. Considering the entire study population, even albuminuria at 1-2 μg/min was significantly associated with increased risk compared with albuminuria
Published: 2012

20. Glomerular hyperfiltration and renal disease progression in type 2 diabetes

Author: Alessandro Roberto Dodesini, Silvia Ferrari, Nicola Motterlini, Antonio Cannata, Piero Ruggenenti, Antonio Bossi, Esteban Porrini, Claudia Cella, Jelka Zaletel, Flavio Gaspari, Nadia Stucchi, Giuseppe Remuzzi, Ilian Iliev, Roberto Trevisan, Fabiola Carrara, Aneliya Parvanova, Ruggenenti, P, Porrini, E, Gaspari, F, Motterlini, N, Cannata, A, Carrara, F, Cella, C, Ferrari, S, Stucchi, N, Parvanova, A, Iliev, I, Dodesini, A, Trevisan, R, Bossi, A, Zaletel, J, and Remuzzi, G
Subjects: Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Kidney Glomerulus, Urology, Renal function, Type 2 diabetes, Nephropathy, Cohort Studies, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Aged, Advanced and Specialized Nursing, business.industry, Hazard ratio, Middle Aged, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Diabetic Nephropathie, Microalbuminuria, Female, Cohort Studie, medicine.symptom, Kidney Glomerulu, business, Glomerular hyperfiltration, Human, Glomerular Filtration Rate
Abstract: OBJECTIVE To describe the prevalence and determinants of hyperfiltration (glomerular filtration rate [GFR] ≥120 mL/min/1.73 m2), GFR decline, and nephropathy onset or progression in type 2 diabetic patients with normo- or microalbuminuria. RESEARCH DESIGN AND METHODS We longitudinally studied 600 hypertensive type 2 diabetic patients with albuminuria RESULTS Over a median (range) follow-up of 4.0 (1.7–8.1) years, GFR declined by 3.37 (5.71–1.31) mL/min/1.73 m2 per year. GFR change was bimodal over time: a larger reduction at 6 months significantly predicted slower subsequent decline (coefficient: −0.0054; SE: 0.0009), particularly among hyperfiltering patients. A total of 90 subjects (15%) were hyperfiltering at inclusion, and 11 of 47 (23.4%) patients with persistent hyperfiltration progressed to micro- or macroalbuminuria versus 53 (10.6%) of the 502 who had their hyperfiltration ameliorated at 6 months or were nonhyperfiltering since inclusion (hazard ratio 2.16 [95% CI 1.13–4.14]). Amelioration of hyperfiltration was independent of baseline characteristics or ACE inhibition. It was significantly associated with improved BP and metabolic control, amelioration of GDR, and slower long-term GFR decline on follow-up. CONCLUSIONS Despite intensified treatment, patients with type 2 diabetes have a fast GFR decline. Hyperfiltration affects a subgroup of patients and may contribute to renal function loss and nephropathy onset or progression. Whether amelioration of hyperfiltration is renoprotective is worth investigating.
Published: 2012

21. Bolus calculator improves long-term metabolic control and reduces glucose variability in pump-treated patients with Type 1 diabetes

Author: C. Scaranna, I. Nosari, Giuseppe Lepore, R. Trevisan, Anna Maria Corsi, Alessandro Roberto Dodesini, Lepore, G, Dodesini, A, Nosari, I, Scaranna, C, Corsi, A, and Trevisan, R
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Infusions, Subcutaneous, Automation, Bolus (medicine), Insulin Infusion Systems, Software Design, Internal medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Drug Dosage Calculations, Glycated Hemoglobin, Type 1 diabetes, Nutrition and Dietetics, business.industry, Blood Glucose Self-Monitoring, Equipment Design, type 1 diabetes, glucose variability, bolus calculator, Middle Aged, medicine.disease, Hypoglycemia, Diabetes Mellitus, Type 1, Treatment Outcome, Metabolic control analysis, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers
Published: 2012

22. Poor glucose control in the year before admission as a powerful predictor of amputation in hospitalized patients with diabetic foot ulceration

Author: Bruno Minetti, M. L. Maglio, I. Nosari, Alessandro Roberto Dodesini, Giuseppe Lepore, Roberto Trevisan, Carlo Cuni, Lepore, G, Maglio, M, Cuni, C, Dodesini, A, Nosari, I, Minetti, B, and Trevisan, R
Subjects: Blood Glucose, Male, medicine.medical_specialty, Glucose control, Hospitalized patients, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Disease duration, amputation, diabetes mellitus, hyperglycemia, Amputation, Surgical, Internal medicine, Diabetes mellitus, Internal Medicine, Medicine, Humans, Aged, Advanced and Specialized Nursing, business.industry, medicine.disease, Diabetic foot, Diabetic Foot, Surgery, Amputation, Observational study, Female, business, Diabetic foot ulceration
Abstract: Although there is a strong association between lower-extremity amputation (LEA) and HbA1c (A1C) in diabetic patients (1,2), little information is available on glucose control in the period preceding and following LEA (3). Our objective was to evaluate the predictors of LEA and to examine the role of blood glucose control during the year before and the year after admission. A total of 122 diabetic patients (82 men and 40 women aged 69.7 ± 10.9 years, disease duration 19.7 ± 10.4 years) consecutively admitted for diabetic foot ulcers to the Medicine Department of United Hospitals of Bergamo between January 2003 and December 2004 were enrolled in our observational study and assigned to one …
Published: 2006

23. Lipids and renal disease

Author: Roberto Trevisan, Alessandro Roberto Dodesini, Giuseppe Lepore, Trevisan, R, Dodesini, A, and Lepore, G
Subjects: Nephrology, medicine.medical_specialty, urologic and male genital diseases, High cholesterol, Insulin resistance, Risk Factors, Internal medicine, medicine, Humans, Triglycerides, business.industry, Glomerulosclerosis, Lipid metabolism, General Medicine, medicine.disease, Lipid Metabolism, Lipids, Chronic renal disease, nephrotic syndrome, dyslipidemia, statin, Endocrinology, Cholesterol, Disease Progression, Kidney Failure, Chronic, lipids (amino acids, peptides, and proteins), Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Nephrotic syndrome, Dyslipidemia, Kidney disease
Abstract: Chronic renal disease is accompanied by characteristic abnormalities of lipid metabolism, which appear as a consequence of nephrotic syndrome or renal insufficiency and are reflected in an altered apolipoprotein profile as well as elevated plasma lipid levels. Experimental and clinical studies have suggested a correlation between the progression of renal disease and dyslipidemia. High cholesterol and triglyceride plasma levels have been demonstrated to be independent risk factors for progression of renal disease in humans. The underlying pathophysiologic mechanisms for the relationship between lipid levels and progression of renal disease are not yet fully understood, although there are data that oxidative stress and insulin resistance may mediate the lipid-induced renal damage. In the animal model, lipid-lowering agents seem to ameliorate glomerular damage, preventing glomerulosclerosis and interstitial fibrosis. Although evidence from clinical studies indicates that statin therapy is associated with significant benefit in individuals with established chronic renal failure, whether lipid reduction can slow the renal functional decline awaits a primary renal outcome lipid-lowering therapy study.
Published: 2006

24. Insulin resistance and the cluster of abnormalities related to the metabolic syndrome are associated with reduced glomerular filtration rate in patients with type 2 diabetes

Author: Stefano Angelo Santini, Salvatore De Cosmo, Vincenzo Trischitta, Raffaella Viti, Monica Vedovato, Antonio Minenna, Paola Fioretto, Alessandro Roberto Dodesini, Roberto Trevisan, De Cosmo, S, Trevisan, R, Minenna, A, Vedovato, M, Viti, R, Santini, S, Dodesini, A, Fioretto, P, and Trischitta, V
Subjects: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Renal function, Type 2 diabetes, Kidney, urologic and male genital diseases, Gastroenterology, chemistry.chemical_compound, Insulin resistance, Insulin resistance, metabolic syndrome, glomerular filtration rate, type 2 diabetes, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, MED/13 - ENDOCRINOLOGIA, Aged, Metabolic Syndrome, Advanced and Specialized Nursing, Creatinine, Type 1 diabetes, business.industry, Middle Aged, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Female, Insulin Resistance, Metabolic syndrome, business, Glomerular Filtration Rate, Kidney disease
Abstract: Because of its devastating outcomes, including end-stage renal disease and increased cardiovascular morbidity and mortality (1–3), chronic kidney disease (CKD) is a worldwide public health problem (4). Diabetes is the leading cause of end-stage renal disease in the Western world (5). Several evidences suggest that insulin resistance and the metabolic syndrome are associated with and probably contribute to reduced glomerular filtration rate (GFR) in patients with type 1 diabetes (6,7). At variance, no data are available in type 2 diabetes. The aim of this work was to investigate the role of insulin resistance and the cluster of metabolic syndrome–related (MS-r) abnormalities on kidney function in patients with type 2 diabetes. Two samples were studied. Selection criteria and clinical features of the first samples have been already published (8). Briefly, 731 type 2 diabetic patients (384 men and 347 women, age 61.4 ± 10 years, diabetes duration 10.8 ± 9 years, HbA1c [A1C] 8.2 ± 1.5%) were consecutively recruited at the Casa Sollievo della Sofferenza Institute in San Giovanni Rotondo. Standardized serum creatinine was measured by the modified kinetic Jaffe reaction. Micro- or macroalbuminuria was diagnosed when albumin-to-creatinine ratio (ACR) was ≥2.5 mg/mmol in men and 3.5 mg/mmol in women; 216 patients (29%) had macroalbuminuria. Estimated GFR was calculated with the abbreviated MDRD (Modification of Diet inRenal Disease) formula (9). CKD was defined as estimated GFR
Published: 2006

25. Preventing microalbuminuria in type 2 diabetes

Author: Anelja Parvanova Ilieva, Antonio Bossi, Piero Ruggenenti, Alessandro Roberto Dodesini, Anna Fassi, Roberto Trevisan, Flavio Gaspari, Ilian Iliev, Giulia Gherardi, Annalisa Perna, Nadia Rubis, Giuseppe Remuzzi, Varusca Brusegan, Bogdan Ene-Iordache, Federica Arnoldi, Simona Bruno, Maria Ganeva, Ruggenenti, P, Fassi, A, Ilieva, A, Bruno, S, Iliev, I, Brusegan, V, Rubis, N, Gherardi, G, Arnoldi, F, Ganeva, M, Ene-Iordache, B, Gaspari, F, Perna, A, Bossi, A, Trevisan, R, Dodesini, A, and Remuzzi, G
Subjects: Trandolapril, Adult, Male, medicine.medical_specialty, Indoles, Urology, Angiotensin-Converting Enzyme Inhibitors, Type 2 diabetes, Placebo, Double-Blind Method, Diabetes mellitus, medicine, Albuminuria, Humans, Type 2 diabetes, microalbuminuria, angiotensin-converting-enzyme inhibitors, non-dihydropyridine calcium-channel blockers, MED/13 - ENDOCRINOLOGIA, Antihypertensive Agents, Aged, Proportional Hazards Models, Proteinuria, business.industry, Type 2 Diabetes Mellitus, General Medicine, Middle Aged, medicine.disease, Calcium Channel Blockers, Surgery, Treatment Outcome, Diabetes Mellitus, Type 2, Verapamil, Hypertension, Disease Progression, Microalbuminuria, Drug Therapy, Combination, Female, medicine.symptom, business, medicine.drug
Abstract: BACKGROUND: The multicenter double-blind, randomized Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) was designed to assess whether angiotensin-converting-enzyme inhibitors and non-dihydropyridine calcium-channel blockers, alone or in combination, prevent microalbuminuria in subjects with hypertension, type 2 diabetes mellitus, and normal urinary albumin excretion. METHODS: We studied 1204 subjects, who were randomly assigned to receive at least three years of treatment with trandolapril (at a dose of 2 mg per day) plus verapamil (sustained-release formulation, 180 mg per day), trandolapril alone (2 mg per day), verapamil alone (sustained-release formulation, 240 mg per day), or placebo. The target blood pressure was 120/80 mm Hg. The primary end point was the development of persistent microalbuminuria (overnight albumin excretion, ≥20 μg per minute at two consecutive visits). RESULTS: The primary outcome was reached in 5.7 percent of the subjects receiving trandolapril plus verapamil, 6.0 percent of the subjects receiving trandolapril, 11.9 percent of the subjects receiving verapamil, and 10.0 percent of control subjects receiving placebo. The estimated acceleration factor (which quantifies the effect of one treatment relative to another in accelerating or slowing disease progression) adjusted for predefined baseline characteristics was 0.39 for the comparison between verapamil plus trandolapril and placebo (P=0.01), 0.47 for the comparison between trandolapril and placebo (P=0.01), and 0.83 for the comparison between verapamil and placebo (P=0.54). Trandolapril plus verapamil and trandolapril alone delayed the onset of microalbuminuria by factors of 2.6 and 2.1, respectively. Serious adverse events were similar in all treatment groups. CONCLUSIONS: In subjects with type 2 diabetes and hypertension but with normoalbuminuria, the use of trandolapril plus verapamil and trandolapril alone decreased the incidence of microalbuminuria to a similar extent. The effect of verapamil alone was similar to that of placebo.
Published: 2004

26. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. Nguyen, J Farmer, M H Tan, Kwon H-S., J Yang, L Sandvik, Franco Folli, A K Jenum, M Nguyen, W Pratipanawatr, A L Frederiksen, Rebecca Smith, Lee H-J., A Schäfer, C Manuelli, G S Denver, T Vukovich, B Maceira, K Matsumoto, K. Chokkalingam, Nurcan Üçeyler, P Modi, Timothy M. Morgan, S Mertens, B M Singh, Michaela Riedl, K Iso, C Cucurullo, G. F. Bottazzo, M Calvani, K Hur, J Wetzels, Kazuhiro Takahashi, Y Aso, H Stammer, M G Masding, Fitsum Guebre-Egziabher, J L González-Sánchez, L Armstrong, Alberto Maran, Peter G.F. Swift, S S Popovic, J Starczynski, E Vitacolonna, Luigi Laviola, R W Gelling, Marina Cardellini, D Barilla, Rosa de Diego Martínez, W H Landschulz, Anne Mette Rosenfalck, R K Wong, Kevin E. Schneider, K Peros, Giuseppe Nanni, F Zhang, I Rákóczi, T Iburi, M Nakhjavani, X Q Zhang, S Tournis, Per Lav Madsen, Graham A. Hitman, A. Tura, K Laubner, N D Kostic, Lawrence M. Dolan, R. Sinha Roy, J A Wagner, J. Tuomilehto, J Hauptman, M Abdel-Ghany, D Lacombe, Toralph Ruge, Johannes A Maassen, Triantafyllos Didangelos, K Sasaki, I Argüelles, Klaus Levin, C Popow, Emanuel Christ, R Chetty, L Baillet-Blanco, Jo-Ann Salmon, T Mine, James L. Trevaskis, I Franke, J Gorski, E A Andrianova, A Dayan, A Caballero, Aleksandra Gilis-Januszewska, M Yasujima, Z Kasalová, C.D.A. Stehouwer, F. K. Gorus, G A Nichols, A Glowania, David P. Strachan, P Fredlund, N. F. da Silva, P Reboldi, M Sausbier, K H Groenier, G Stuccio, N Guttman, K R Ahmed, A D Ristic, T Kapellen, J Coutcher, Aldo V. Greco, Oswald Wagner, A Zagayko, Maria Alevizaki, B B Zhang, W F Ferris, Jenny Fredriksson, Lois Jovanovic, J Hänninen, R De Giglio, Kazuo Yagui, O Potterat, P Hamliton, R E Scranton, B Mankovsky, A Stylianou, B Fellström, Abdel-Wahab Yha., M Kitagawa, Katherine L. Baldock, F R Johnson, F Baigts, S D'Addato, F J Sanz, A Mistry, S D Wise, T Pratipanawatr, U R Fölsch, James R.C. 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S, Choi, D, Kim, N, Matsumoto, S, Suetsugu, M, Matsutomo, R, Pisarczyk wiza, D, Banaszak, A, Wysocki, H, Usui, H, Shikata, K, Okada, S, Ogawa, D, Yozai, K, Kido, Y, Nagase, R, Ohga, S, Tone, A, Sasaki, M, Wada, J, Unno, Y, Horiuchi, S, Mclennan, S, Kamarinos, M, Waltham, M, Dy, V, Yue, D, Zdychova, J, Komers, R, Cresci, B, Giannini, S, Manuelli, C, Giunti, S, Pinach, S, Ianni Palarchio, A, Arnaldi, L, Vittone, F, Camussi, G, Cavallo Perin, P, Gruden, G, Marshall, S, Jones, S, White, K, Brizzi, M, Dentelli, P, Rosso, A, Calvi, C, Gambino, R, Cassader, M, Salvidio, G, Deferrari, G, Pegoraro, L, Pagano, G, Cavallo perin, P, Oates, R, Ellery, C, Beebe, D, Coutcher, J, Qian, Y, Lowe, V, Appleton, T, Raunig, D, O'Neil, S, Mylari, B, Amazonas, R, Fujita, A, Doi, A, Matsuno, S, Okamoto, K, Matsumoto, E, Furuta, H, Nishi, M, Tsuno, T, Taniguchi, H, Bessho, H, Wasén, E, Isoaho, R, Mattila, K, Vahlberg, T, Kivelä, S, Irjala, K, Rigalleau, V, Lasseur, C, Perlemoine, C, Barthes, N, Raffaitin, C, Chauveau, P, Combe, C, Baillet blanco, L, Beauvieux, M, Gin, H, Heinrich, S, Steiner, T, Ott, U, Holdass, H, Fellström, B, Jardine, A, Staffler, B, Logan, J, Gimpelewicz, C, Stanciu, C, Pena, C, Serafinceanu, C, González posada, J, Hernández, D, Pérez tamajó, L, Ló, A, Herná Alarcó, M, Meneses, M, Barsotti, M, Rizzo, G, Schmauss, S, Havrdova, T, Saudek, F, Boucek, P, Adamec, M, Invitti, C, Gilardini, L, Parati, G, Mazzilli, G, Pontiggia, B, Sartorio, A, Lutgers, H, Groenier, K, Zasadzinska, G, Saryusz wolska, M, Kurktschiev, D, Majdrakova, I, Varbanova, T, Todorova, B, Bajo martinez, A, Bernal, E, Sanchez, O, Ugalde canitrot, A, Sanchez largo, E, Coca robinot, D, Fabregate, R, Calbacho, M, Marquez, J, Saban ruiz, J, Penesova, A, Cizmarova, E, Blazicek, P, De Jongh, R, Serné, E, Ijzerman, R, De Vries, G, Andersen, N, Knudsen, S, Helleberg, K, Mogensen, C, Waluś, M, Idzior waluś, B, Sztefko, K, Cieślik, G, Fedak, D, Wozniakiewicz, E, Lin, S, Guo, M, Lin, C, Liu, X, Francisco, M, Rodriguez rosas, H, Peiró martinez, I, Macías batista, A, Harte, A, Rodriguez cuenca, S, Valsamakis, G, Chetty, R, Anderson, L, Roca, P, Matyka, K, Lasalle, J, Hershon, K, Berman, L, Gibson, E, Gillen, D, Maroni, J, Simmons, D, Hiukka, A, Forder, P, Leinonen, E, Hilden, H, Fruchart, J, Keech, A, Farnier, M, Freeman, M, Macdonell, G, Perevozskaya, I, Mitchel, Y, Gumbiner, B, Didangelos, T, Athyros, V, Mikhailidis, D, Papageorgiou, A, Bouloukos, V, Pehlivanidis, A, Symeonidis, A, Elisaf, M, Mckenney, J, Insull, W, Lewin, A, Maccubbin, D, Kush, D, Schuster, H, Barter, P, Stender, S, Bonnet, J, Morrell, J, Watkins, C, Kallend, D, Stalenhoef, A, Ballantyne, C, Murin, J, Tonstad, S, Rose, H, Wilpshaar, W, Jenkins, A, Karschimkus, C, Dragicevic, G, Rowley, K, Wolthers, T, Best, J, Voet, B, Murdoch, S, Marcovina, S, Brunzell, J, Caparevic, Z, Kostic, N, Ilic, S, Sartore, G, Piarulli, F, Cantaro, S, Reitano, R, Fiore, C, Marin, R, Bassan, S, Manzato, E, Fedele, D, Solini, A, Santini, E, Thornalley, P, Babaei jadidi, R, Karachalias, N, Kupich, C, Ahmed, N, Fowler, A, Baker, A, Starczynski, J, O'Hare, P, Szepietowska, B, Szelachowska, M, Puch, U, Glebocka, A, Quinn, D, Mcternan, C, Bonser, R, Idzior walus, B, Woźniakiewicz, E, Dimitriou, K, Apostolou, O, Kontela, E, Devangelio, E, Gould, E, Serri, O, Roussin, A, Buithieu, J, Mamputu, J, Renier, G, Giordanetti, S, De Amici, E, Poggi, G, Turpini, C, Fratino, P, Garzaniti, A, Banu, I, Paries, J, Roman, G, Negrean, M, Bala, C, Nita, C, Kistorp, C, Gustafsson, F, Chong, A, Lip, G, Galatius, S, Ari, N, Sahilli, M, Ceylan isık, A, Ozansoy, G, Karasu yilmaz, C, Matteucci, E, Rosada, J, Pallini, M, Evangelista, I, Cassetti, G, Giusti, C, Giampietro, O, Capaldo, B, Galderisi, M, Cicala, S, Turco, A, Imbroinise, A, Nosso, G, D'Errico, A, De Divitiis, O, Klimontov, V, Korolyova, E, Jeltova, L, Bondar, I, Tarkun, I, Arslan, B, Canturk, Z, Tarkun, P, Agacdiken, A, Komsuoglu, B, Méneveau, N, Pierre justin, E, Alsayed, M, Sabbah, R, Paulin, S, Marcu, S, Tauveron, I, Zimmermann, C, Schiele, F, Seronde, M, Vautrin, P, Lusson, J, Thieblot, P, Bernard, Y, Mistry, A, Pye, M, Peovska, I, Maksimovic Pavlovic, J, Vavlukis, M, Pop Gorceva, D, Bosevski, M, Scognamiglio, R, Negut, C, De Kreutzenberg, S, Madonna, R, De Caterina, R, Willerson, J, Geng, Y, Vahsen, S, Ledwig, D, Ramrath, S, Frantz, S, Schmidt, I, Calvillo, L, Dienesch, C, Elbing, I, Bischoff, H, Ertl, G, Bauersachs, J, Davydov, A, Mkrtum'Yan, A, Baranova, L, Ikeda, Y, Suehiro, T, Osaki, F, Ota, K, Arii, K, Kumon, Y, Hashimoto, K, Doney, A, Morris, A, Palmer, C, Byun, S, Doo, H, Pagnin, E, Calo, L, Fadini, G, Kubaszek, A, Chai, S, Chai, Q, Rasmussen, L, Ledet, T, Wogensen, L, Lengyel, C, Varró, A, Virág, L, Magyar, J, Bíró, T, Jost, N, Skoumal, R, Nánási, P, Tóth, M, Horkay, F, Papp, J, Zacharopoulou, O, Athanaselis, S, Tsokos, N, Doupis, J, Psallas, M, Cokkinos, D, Pavlatos, S, Liatis, S, Akhobadze, T, Dzneladze, L, Samarguliani, I, Taskiran, M, Rasmussen, V, Jensen, G, Fisher, A, Petrovsky, N, Srikusalanukul, W, Budge, M, Trifunovic zamaklar, D, Zivkovic, M, Jelic, V, Vukomanovic, G, Ristic, A, Seferovic, P, Costa, J, Duarte, S, Manley, S, Sailesh, S, Venkataraman, A, Haider, Y, Groza, I, Oprean, M, Ardelean, A, Morosanu, A, Darkow, T, Vanderplas, A, Mamas, M, Mcelduff, P, Burns, J, Edwards, R, Fitchet, A, Young, R, Gibson, J, Lichiardopol, R, Niculescu, N, Totora, A, Pencea, C, Tomescu, I, Cinteza, M, Manicardi, V, Coscelli, C, Navazio, A, Catellani, E, Michelini, M, Dall'Asta, D, Guberti, A, Piazza, A, Gasparini, E, Pantaleoni, M, Guiducci, U, Manari, A, Sejil, S, Janand delenne, B, Avierinos, J, Habib, G, Labastie, N, Vague, P, Lassmann vague, V, Luźniak, P, Tatoń, J, Wojciechowska Luźniak, A, Zairis, M, Lyras, A, Patsourakos, N, Tsirimbis, V, Foussas, S, Lupón, J, Urrutia, A, Herreros, J, González, B, Coll, R, Altimir, S, Prats, M, Valle, V, Abreu padí, C, Rábago, G, Ivanova, L, Brasacchio, D, Harno, E, Keenan, A, Li, H, Lu, Z, Ke, L, Liu, H, Jeong, I, Chae, M, Choi, M, Yoo, H, Kim, C, Yun, M, Na, M, Kang, Y, Kong, O, Son, S, Kim, I, Tanaka, N, Hosoi, M, Matsuyama, Y, Fukumoto, M, Yamakita, T, Yoshioka, K, Ishii, T, Sato, T, Fujii, S, Aoki, T, Shibata, T, Mizutani, N, Suzuki, J, Fowelin, J, Samuelsson, P, Brandrup wogsen, G, Okumura, K, Tokmakova, A, Staroverova, D, Antcieferov, M, Shutichina, I, Kuntchevich, G, Vriesendorp, T, Morélis, Q, Legemate, D, Schaper, F, Mainas, E, Gkioulmpasanis, I, Panagiotou, I, Vassilikos, G, Skorda, L, Sidira, M, Christoforidou, M, Alaveras, A, Artikis, V, Evdemon, E, Lechleitner, M, Koch, T, Ebenbichler, C, Sturm, W, Moretti, L, Moruzzo, D, Boldrini, E, Pandolfo, C, Kameyama, M, Iwasa, R, Cho, M, Nam, J, Huh, K, Kaplar, M, Paragh, G, Erdei, A, Csongradi, E, Garai, I, Varga, J, Galuska, L, Udvardy, M, Higa, M, Kaneko, Y, Hiroi, N, Koziarska, D, Nowacki, P, Majkowska, L, Luzniak, P, Wojciechowska luźniak, A, Tushuizen, M, Nieuwland, R, Snoeck, D, Sturk, A, Diamant, M, Aguiar, L, Bahia, L, Villela, N, Laflor, C, Conde, C, Bottino, D, Dorigo, D, Bouskela, E, Pu, S, Luo, Z, Lam, K, Dan, Q, Xu, A, Shen, J, Cheng, K, Xu, J, Thamer, C, Stefan, N, Haap, M, Heller, E, Tschritter, O, De Prado, A, Ortiz, A, Ybarra, J, Gich, I, Pou, J, Ehren, M, Roggenland, D, Reinsen, B, Klein, H, Rittig, K, Stock, J, Kocher, B, Balletshofer, B, Shon, H, Chung, D, Nakatani, Y, Matsuhisa, M, Kaneto, H, Hatazaki, M, Yoshiuchi, K, Katakami, N, Kawamori, D, Ohtoshi, K, Sakamoto, K, Matsuoka, T, Ozawa, K, Ogawa, S, Hori, M, Yamasaki, Y, Zitouni, K, Harry, D, Nourooz zadeh, J, Earle, K, Olesen, P, Franco, L, Corvaja, C, Semplicini, A, Ceylan işık, A, Arı, N, Rösen, P, Lee, I, Park, K, Jung, E, Shin, D, Jo, S, Obuobie, K, Prakash, P, Hanna, F, Lazarus, J, Varadhan, L, Gurushankar, J, James, D, Sheikh, S, Gaede, P, Zou, D, Vilarrasa, N, Perez maraver, M, Mena, E, Perez, D, Setti, G, Buckingham, R, Urbančič, V, Stefanovska, A, Bernjak, A, Ažman juvan, K, Kocijančič, A, Glowania, A, Filters, T, Fosmark, D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

27. Effect of sodium intake on blood pressure and albuminuria in Type 2 diabetic patients: the role of insulin resistance

Author: Alessandro Roberto Dodesini, Antonio Tiengo, Roberto Trevisan, E. Jori, Giuseppe Lepore, S. Del Prato, Anna Coracina, Monica Vedovato, Vedovato, M, Lepore, G, Coracina, A, Dodesini, A, Jori, E, Tiengo, A, Del Prato, S, and Trevisan, R
Subjects: Blood Glucose, Male, Renal Plasma Flow, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Blood Pressure, Type 2 diabetes, urologic and male genital diseases, Type 2 diabete, Intraglomerular pressure, Renin, Insulin, Aldosterone, Glucose clamp technique, Diet, Sodium-Restricted, Middle Aged, female genital diseases and pregnancy complications, Salt sensitivity, Female, medicine.symptom, Glomerular Filtration Rate, medicine.medical_specialty, Insulin resistance, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Serum Albumin, urogenital system, business.industry, Patient Selection, Body Weight, Sodium, medicine.disease, Diet, Endocrinology, Blood pressure, Diabetes Mellitus, Type 2, Glucose Clamp Technique, Linear Models, Potassium, Microalbuminuria, Insulin Resistance, business
Abstract: Aims/hypothesis. This study was done to measure the effect of Na + intake on blood pressure and albuminuria, in relation with insulin sensitivity and kidney haemodynamics, in Type 2 diabetic patients with and without microalbuminuria. Methods. Type 2 diabetic patients, 20 with microalbuminuria, 21 without, spent two consecutive 7-day periods, one on a high (250 mmol), the other on a low-Na+ (20 mmol) diet. Body weight, 24-h blood pressure and albuminuria were measured at the end of each period. At the end of high-Na+ diet insulin sensitivity (euglycaemic insulin clamp; 2 mU·kg-1·min-1) and kidney haemodynamics were measured in nine patients from each group. Results. Switching from low to high-Na+ diet resulted in an increase in blood pressure (7.4±4.7 mmHg; p
Published: 2003

28. Cost-effectiveness of two screening programs for microalbuminuria in type 2 diabetes

Author: Alessandro Roberto Dodesini, Roberto Trevisan, M. L. Maglio, I. Nosari, Giuseppe Lepore, Lepore, G, Maglio, M, Nosari, I, Dodesini, A, and Trevisan, R
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, Cost effectiveness, business.industry, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, urologic and male genital diseases, medicine.disease, Surgery, Urine collection device, Nephropathy, Internal medicine, Diabetes mellitus, Internal Medicine, Albuminuria, Medicine, Outpatient clinic, Microalbuminuria, medicine.symptom, microalbuminuria, type 2 diabetes, screening, business
Abstract: The presence of microalbuminuria is associated with an increased risk for developing nephropathy and cardiovascular diseases in both type 1 and type 2 diabetes (1,2,3). A proper pharmacological treatment can reduce urinary albumin excretion rate (AER) and prevent clinical nephropathy. Consequently, the screening for microalbuminuria should be an essential tool of the care for diabetic patients. Controversy still exists regarding the type of urine specimen to be used to evaluate microalbuminuria. AER determined in timed urine collections (24 h or overnight) is the most direct measure of urinary albumin excretion (4,5). However, due to the demand of the protocol and frequent imperfect patient adherence, the AER is not practical for epidemiological studies or clinical settings. For these reasons, the measurement of the albumin-to-creatinine ratio (ACR) in a random spot urine has became a widely accepted clinical tool for assessing urinary albumin excretion (6,7,8). Recently, several semiquantitative office tests for detecting abnormal albuminuria have been developed (9). The aim of our study was to identify the easiest and most cost-effective screening program for microalbuminuria in an outpatient clinic. We evaluated specificity, sensitivity, and positive (PPV) and negative (NPV) predictive values …
Published: 2002

29. 278: Impact of pre-pregnancy body mass index on maternal and fetal outcomes in type 1 diabetitc preganancy (T1DM)

Author: Serena Pirola, Luigi Frigerio, Nicola Strobelt, Santa Barresi, Giorgia Cavalli, Alessandro Roberto Dodesini, Roberto Trevisan, Luisa Patanè, and Elena Ciriello
Subjects: Fetus, medicine.medical_specialty, Obstetrics, business.industry, Pre pregnancy, medicine, Obstetrics and Gynecology, business, Body mass index
Published: 2013

30. 279: Maternal serum A1C levels and triglycerides as predictive factors for LGA newborns in type 1 diabetic women

Author: Alessandro Roberto Dodesini, Nicola Strobelt, Giorgia Cavalli, Elena Ciriello, Luigi Frigerio, Serena Pirola, Santa Barresi, Roberto Trevisan, and Luisa Patanè
Subjects: Type 1 diabetes, Pregnancy, medicine.medical_specialty, Fetus, business.industry, Obstetrics, Obstetrics and Gynecology, Gestational age, Retrospective cohort study, medicine.disease, Obstetrics and gynaecology, Diabetes mellitus, medicine, Population study, business
Abstract: 279 Maternal serum A1C levels and triglycerides s predictive factors for LGA newborns in ype 1 diabetic women Elena Ciriello, Luisa Patane, Serena Pirola, Santa Barresi, iorgia Cavalli, Nicola Strobelt, Luigi Frigerio, Alessandro oberto Dodesini, Roberto Trevisan Ospedali Riuniti, Obstetrics and Gynecology, Bergamo, Italy, Ospedali Riuniti, Diabetology, Bergamo, Italy OBJECTIVE: The aim of the present study was to determine the role of etabolic maternal parameters in predicting large for gestational age LGA) neonates of women with type 1 diabetes mellitus (T1DM). STUDY DESIGN: We conducted a retrospective cohort study of a group of singleton pregnancy with T1DM who delivered in our hospital from June 2004 and June 2012. We compared maternal and fetal outcomes of women who delivered LGA with ones who had AGA newborns. Statistical analysis was performed with Fisher and T-test. RESULTS: A total of 80 women with T1DM delivered during the study eriod. Fifty-four (67%) women had AGA and 26 (33%) LGA babies. o differencies were found in maternal characteristics (maternal age, MI, duration of diabetes, pre-pregnancy diabetic complications, arity) in the study population. Metabolic parameters were evaluated onthly since 5th to 36th week. No significant correlations were ound between LGA rate and maternal total cholesterol or HDL choesterol levels and uric acid. Maternal A1C levels and fasting serum riglyceride were significantly higher in the second and in the third rimester in LGA group compared with other mothers (Table). CONCLUSION: These observations are in accordance with other reports and suggest that there is an association between A1C levels and heavier neonates in T1DM women. Maternal triglycerids may be considered a new predictor of neonatal birthweight. Lipid levels throughout pregnancy and their association need to be studied in women with type 1 diabetes mellitus.
Published: 2013

31. Both Continuous Subcutaneous Insulin Infusion and a Multiple Daily Insulin Injection Regimen With Glargine as Basal Insulin Are Equally Better Than Traditional Multiple Daily Insulin Injection Treatment

Author: I. Nosari, Alessandro Roberto Dodesini, Roberto Trevisan, Giuseppe Lepore, Lepore, G, Dodesini, A, Nosari, I, and Trevisan, R
Subjects: Advanced and Specialized Nursing, Type 1 diabetes, medicine.medical_specialty, business.industry, Insulin glargine, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Hypoglycemia, medicine.disease, law.invention, Endocrinology, Basal (medicine), Randomized controlled trial, law, Diabetes mellitus, Internal medicine, Anesthesia, Internal Medicine, medicine, continuous subcutaneous insulin infusion, multiple daily insulin injection, insulin glargine, Insulin lispro, business, medicine.drug
Abstract: Diabetes Control and Complications Trial results showed that strict metabolic control may substantially reduce the risk of long-term microvascular complications (1). Over the study period, which averaged 7 years, the mean HbA1c level in the intensive group treatment was 7.2%. Current guidelines of treatment for type 1 diabetes propose a goal of HbA1c
Published: 2003

32. Postprandial Hyperglycemia Is Associated With an Increase of Blood Pressure in Type 1 Diabetic Patients Treated With Continuous Subcutaneous Insulin Infusion

Author: I. Nosari, Alessandro Roberto Dodesini, Roberto Trevisan, Giuseppe Lepore, Anna Maria Corsi, Lepore, G, Corsi, A, Dodesini, A, Nosari, I, and Trevisan, R
Subjects: Adult, Diabetes duration, medicine.medical_specialty, Injections, Subcutaneous, Endocrinology, Diabetes and Metabolism, Blood Pressure, diabetes, hyperglycaemia, blood pressure, continuous subcutaneous insulin infusion, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, MED/13 - ENDOCRINOLOGIA, Advanced and Specialized Nursing, Type 1 diabetes, Meal, Acute hyperglycemia, business.industry, Middle Aged, Postprandial Period, medicine.disease, Subcutaneous insulin, Diabetes Mellitus, Type 1, Endocrinology, Blood pressure, Postprandial, Hyperglycemia, Cardiology, business
Abstract: Blood pressure normally decreases after a meal and reaches a nadir between 30 and 60 min after eating (1). Giugliano et al. (2) showed that acute hyperglycemia in normal subjects significantly increases systolic and diastolic blood pressure. To define the relationship between postprandial plasma glucose excursions and blood pressure variations in type 1 diabetes, we studied 10 normotensive, type 1 diabetic patients (mean ± SD age 39.7 ± 16.7 years, diabetes duration 10.5 ± 5.4 years, A1C 7.4 ± 0.8%, and BMI 23.9 ± 3.5 kg/m2) without microangiopatic complications. All patients were in therapy with continuous subcutaneous insulin infusion. None took any hypotensive drug. …
Published: 2007

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32 results on '"Alessandro Roberto Dodesini"'

1. Impact of a Complement Factor H Gene Variant on Renal Dysfunction, Cardiovascular Events, and Response to ACE Inhibitor Therapy in Type 2 Diabetes

2. Switching to the Minimed™ 780G system achieves clinical targets for CGM in adults with type 1 diabetes regardless of previous insulin strategy and baseline glucose control

3. Real-World Insulin Treatment in Pregnant Women with Type 1 Diabetes Using an Advanced Hybrid Closed-Loop System

4. An Experience of Insulin Basal Titration in Lombardy (Italy) during the Pandemic

5. Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study

6. Switching from Suspend-Before-Low Insulin Pump Technology to a Hybrid Closed-Loop System Improves Glucose Control and Reduces Glucose Variability: A Retrospective Observational Case–Control Study

7. Resilience in pregnant women with pre-gestational diabetes during COVID-19 pandemic: the experience of the Papa Giovanni XXIII Hospital in Bergamo, Italy

8. Pre-gestational diabetes during the COVID-19 pandemic in Bergamo, Italy

9. Contents Vol. 136, 2017

10. Continuous subcutaneous insulin infusion reduces maternal and neonatal risk in pregnant women with type 1 diabetes: An observational cohort study of 122 pregnancies

11. 'MySweetGestation': A novel smartphone application for women with or at risk of diabetes during pregnancy

12. Review of general suggestions on physical activity to prevent and treat gestational and pre-existing diabetes during pregnancy and in postpartum

13. Effects of a low glycemic index high in fiber diet on blood glucose in women with gestational diabetes

14. The Hyperfiltering Kidney in Diabetes

15. Diabetes - clinical studies

16. Level of implementation of guidelines on screening and diagnosis of gestational diabetes. a national survey

17. Continuous subcutaneous insulin infusion is more effective than multiple daily insulin injections in preventing albumin excretion rate increase in Type 1 diabetic patients

18. Blood pressure and cholesterol levels in an Italian outpatient cohort of type 2 diabetic patients: Comparison with the general population

19. Measurable urinary albumin predicts cardiovascular risk among normoalbuminuric patients with type 2 diabetes

20. Glomerular hyperfiltration and renal disease progression in type 2 diabetes

21. Bolus calculator improves long-term metabolic control and reduces glucose variability in pump-treated patients with Type 1 diabetes

22. Poor glucose control in the year before admission as a powerful predictor of amputation in hospitalized patients with diabetic foot ulceration

23. Lipids and renal disease

24. Insulin resistance and the cluster of abnormalities related to the metabolic syndrome are associated with reduced glomerular filtration rate in patients with type 2 diabetes

25. Preventing microalbuminuria in type 2 diabetes

26. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

27. Effect of sodium intake on blood pressure and albuminuria in Type 2 diabetic patients: the role of insulin resistance

28. Cost-effectiveness of two screening programs for microalbuminuria in type 2 diabetes

29. 278: Impact of pre-pregnancy body mass index on maternal and fetal outcomes in type 1 diabetitc preganancy (T1DM)

30. 279: Maternal serum A1C levels and triglycerides as predictive factors for LGA newborns in type 1 diabetic women

31. Both Continuous Subcutaneous Insulin Infusion and a Multiple Daily Insulin Injection Regimen With Glargine as Basal Insulin Are Equally Better Than Traditional Multiple Daily Insulin Injection Treatment

32. Postprandial Hyperglycemia Is Associated With an Increase of Blood Pressure in Type 1 Diabetic Patients Treated With Continuous Subcutaneous Insulin Infusion

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