1. Three cases of near-tetraploid acute myeloid leukemias originating in pluripotent myeloid progenitors
- Author
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Alena Trpáková, Zuzana Zemanova, Petr Lemež, Jaroslav Jelinek, Kyra Michalova, Iuri Marinov, and Jana Moravcová
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Erythrocytes ,Naphthol AS D Esterase ,Myeloid ,medicine.medical_treatment ,Acid Phosphatase ,CD34 ,Bone Marrow Cells ,Biology ,Immunophenotyping ,Colony-Forming Units Assay ,Polyploidy ,hemic and lymphatic diseases ,Leukocytes ,medicine ,Humans ,Progenitor cell ,neoplasms ,Metaphase ,Aged ,Peroxidase ,Aged, 80 and over ,Chemotherapy ,Cytogenetics ,Myeloid leukemia ,Karyotype ,Hematology ,Middle Aged ,Periodic Acid-Schiff Reaction ,Hematopoietic Stem Cells ,medicine.anatomical_structure ,Oncology ,Leukemia, Myeloid ,Karyotyping ,Acute Disease ,Immunology ,Cancer research ,Female ,Bone marrow ,Carboxylic Ester Hydrolases ,Cell Division - Abstract
We report three cases of acute myeloid leukemia (AML) with a near-tetraploid karyotype in most metaphases while lacking chromosomal abnormalities typical for AML. All patients, 63, 72 and 81 years old, were female. In two cases, AML was diagnosed 5–7 months after a cytopenic period while the third patient had a secondary AML after therapy for a pleural tumor. Leukemic blasts were classified as AML M0, AML M1 and AML without further specification. Two patients died on the 18th and 52nd day after the start of cytotoxic chemotherapy, the third patient refused chemotherapy and died 22 days after the diagnosis. The three patients may represent a distinct AML category with the following features: (1) the near-tetraploid karyotype in most bone marrow metaphases examined at diagnosis of AML; (2) the presence of very large myeloid blasts in the bone marrow and dysplastic changes in erythroid and/or megakaryocytic lineages pointing to the origin of AML in pluripotent myeloid progenitor cells; (3) the expression of the CD34 antigen; (4) the low growth of granulocyte-macrophage colony forming cells in culture; and (5) the presence of a preleukemic phase, a higher age and a poor prognosis.
- Published
- 1998