Search

Dodecahydro-closo-dodecaborate(2-) anion [B12H12]2- as well as carboranes C2B10H12 have been considered for a long time as promising boron moieties for boron neutron capture therapy.1 The main advantages of the [B12H12]2- anion and its derivatives are their high water solubility as sodium salts and simple methods of the parent anion synthesis from 10B-enriched raw material. The main problems of the [B12H12]2- synthetic chemistry compared to that of carborane are the absence of a distinguished reaction center due to its high, close to spherical, symmetry and high reactivity in respect to electrophiles that often give mixtures of products with various substitution degrees. To avoid this complication, the primary introduction of a reaction center (—OH, —SH, —NH2, or —I) is necessary.