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1. The impact of the size of acetylated cyclodextrin on the stability of amorphous metronidazole

Author

Aldona Minecka, Magdalena Tarnacka, Karolina Jurkiewicz, Barbara Hachuła, Roman Wrzalik, Aleksander Bródka, Kamil Kamiński, and Ewa Kamińska

Subjects
Excipients, Cyclodextrins, Calorimetry, Differential Scanning, Drug Stability, Solubility, X-Ray Diffraction, Metronidazole, Pharmaceutical Science, Crystallization
Abstract

Modified oligosaccharides with cyclic topology seem to be promising excipients for the preparation of Amorphous Solid Dispersions (ASDs), especially with those Active Pharmaceutical Ingredients (APIs), which have a strong crystallization tendency from the amorphous/glassy state. Herein, the usefulness of two acetylated cyclodextrins (ac-α-CD and ac-β-CD) with various molecular weights (M

Published
2022
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