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1. Quality Assessment of Dried Blood Spots from Tuberculosis Patients from Four Countries

Author

Zuur, Marlanka A., Veenhof, Herman, Aleksa, Alena, Boveneind-Vrubleuskaya, Natascha van ‘t, Darmawan, Endang, Hasnain, Md Golam, Heysell, Scott K., Jongedijk, Erwin M., Koster, Remco A., Magis-Escurra, Cecile, Martinez, Nilza, Molinas, Gladys, Mondal, Dinesh, Mulyani, Ully Adhie, Perwitasari, Dyah A., Tsivunchyk, Andrej, Touw, Daan J, and Alffenaar, Jan-Wilem C.

Published
2019
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2. Effectiveness and Safety of Imipenem-Clavulanate Added to an Optimized Background Regimen (OBR) Versus OBR Control Regimens in the Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis

Author

Tiberi, Simon, Sotgiu, Giovanni, D'Ambrosio, Lia, Centis, Rosella, Arbex, Marcos Abdo, Arrascue, Edith Alarcon, Alffenaar, Jan Willem, Caminero, Jose A., Gaga, Mina, Gualano, Gina, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Guizado, Valentina Alarcon, De Lorenzo, Saverio, Arias, Aurora Jazmín Roby, Scardigli, Anna, Akkerman, Onno W., Aleksa, Alena, Artsukevich, Janina, Avchinko, Vera, Bonini, Eduardo Henrique, Marín, Félix Antonio Chong, López, Lorena Collahuazo, de Vries, Gerard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, Moschos, Charalampos, Palmieri, Fabrizio, Papavasileiou, Apostolos, Payen, Marie-Christine, Piana, Andrea, Spanevello, Antonio, Vasquez, Dante Vargas, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, and Migliori, Giovanni Battista

Published
2016

3. Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort

Author

Koirala, S., Borisov, Sergey, Danila, Edvardas, Mariandyshev, A., Shrestha, B., Lukhele, N., Dalcolmo, Margareth Pretti, Shakya, S.R., Miliauskas, S., Kuksa, Liga, Manga, Selene, Aleksa, Alena, Denholm, Justin, Khadka, H.B., Skrahina, Alena, Diktanas, S., Ferrarese, Maurizio, Bruchfeld, Judith, Koleva, A., Piubello, Alberto, Koirala, G.S., Udwadia, Zarir Farokh, Palmero, Domingo Juan, Muñoz Torrico, Marcela, GC, R., Gualano, Gina, Grecu, V.I., Motta, I., Papavasileiou, A., Li, Yang, Hoefsloot, Wouter, Kunst, Heinke, Mazza Stalder, J., Payen, Marie Christine, Akkerman, Onno, Bernal, Enrique, Manfrin, Vinicio, Matteelli, Alberto, Mustafa Hamdan, Hamdan, Nieto Marcos, Magnolia, Cadiñanos Loidi, Julen, Cebrian Gallardo, Jose Joaquín, Duarte, Raquel, Escobar Salinas, N., Gomez Rosso, Roscio Gomez, Laniado Laborín, Rafael, Martínez Robles, Elena, Quirós Fernandez, S., Rendón, Adrián, Solovic, Ivan, Tadolini, Marina, Viggiani, Pietro, Belilovski, Evgeny, Boeree, Martin J., Cai, Qingshan, Davidavičienė, Edita, Forsman, L.D., De Los Rios Jefe, Jorge, Drakšienė, J., Duga, A., Elamin, S.E., Filippov, Alexey, Garcia, A., Gaudiesiute, I., Gavazova, B., Gayoso, Regina, Gruslys, V., Jonsson, Jerker, Khimova, E., Madonsela, G., Magis Escurra, C., Marchese, Valentina, Matei, M., Moschos, C., Nakčerienė, B., Nicod, L., Palmieri, Fabrizio, Pontarelli, Agostina, Šmite, Agnese, Souleymane, Mahamadou Bassirou, Vescovo, Marisa, Zablockis, R., Zhurkin, Dmitry, Alffenaar, Jan Willem, Caminero, Jose A., Codecasa, Luigi Ruffo, García García, José María, Esposito, Susanna R., Saderi, L., Spanevello, Antonio, Visca, Dina, Tiberi, Simon, Pontali, Emanuele, Centis, Rosella, D'Ambrosio, L., van den Boom, Martin, Sotgiu, Giovanni, Migliori, Giovanni Battista, Koirala, S., Borisov, Sergey, Danila, Edvardas, Mariandyshev, A., Shrestha, B., Lukhele, N., Dalcolmo, Margareth Pretti, Shakya, S.R., Miliauskas, S., Kuksa, Liga, Manga, Selene, Aleksa, Alena, Denholm, Justin, Khadka, H.B., Skrahina, Alena, Diktanas, S., Ferrarese, Maurizio, Bruchfeld, Judith, Koleva, A., Piubello, Alberto, Koirala, G.S., Udwadia, Zarir Farokh, Palmero, Domingo Juan, Muñoz Torrico, Marcela, GC, R., Gualano, Gina, Grecu, V.I., Motta, I., Papavasileiou, A., Li, Yang, Hoefsloot, Wouter, Kunst, Heinke, Mazza Stalder, J., Payen, Marie Christine, Akkerman, Onno, Bernal, Enrique, Manfrin, Vinicio, Matteelli, Alberto, Mustafa Hamdan, Hamdan, Nieto Marcos, Magnolia, Cadiñanos Loidi, Julen, Cebrian Gallardo, Jose Joaquín, Duarte, Raquel, Escobar Salinas, N., Gomez Rosso, Roscio Gomez, Laniado Laborín, Rafael, Martínez Robles, Elena, Quirós Fernandez, S., Rendón, Adrián, Solovic, Ivan, Tadolini, Marina, Viggiani, Pietro, Belilovski, Evgeny, Boeree, Martin J., Cai, Qingshan, Davidavičienė, Edita, Forsman, L.D., De Los Rios Jefe, Jorge, Drakšienė, J., Duga, A., Elamin, S.E., Filippov, Alexey, Garcia, A., Gaudiesiute, I., Gavazova, B., Gayoso, Regina, Gruslys, V., Jonsson, Jerker, Khimova, E., Madonsela, G., Magis Escurra, C., Marchese, Valentina, Matei, M., Moschos, C., Nakčerienė, B., Nicod, L., Palmieri, Fabrizio, Pontarelli, Agostina, Šmite, Agnese, Souleymane, Mahamadou Bassirou, Vescovo, Marisa, Zablockis, R., Zhurkin, Dmitry, Alffenaar, Jan Willem, Caminero, Jose A., Codecasa, Luigi Ruffo, García García, José María, Esposito, Susanna R., Saderi, L., Spanevello, Antonio, Visca, Dina, Tiberi, Simon, Pontali, Emanuele, Centis, Rosella, D'Ambrosio, L., van den Boom, Martin, Sotgiu, Giovanni, and Migliori, Giovanni Battista

Published
2021

4. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: A global feasibility study

Author

Akkerman, Onno, Aleksa, Alena, Alffenaar, Jan-Willem, Al-Marzouqi, Nada Hassan, Arias-Guillén, Miguel, Belilovski, Evgeny, Bernal, Enrique, Boeree, Martin J., Borisov, Sergey E., Bruchfeld, Judith, Cadiñanos Loidi, Julen, Cai, Qingshan, Caminero, Jose A., Cebrian Gallardo, Jose Joaquín, Centis, Rosella, Codecasa, Luigi Ruffo, D’Ambrosio, Lia, Dalcolmo, Margareth, Danila, Edvardas, Dara, Masoud, Davidavičienė, Edita, Davies Forsman, Lina, De Los Rios Jefe, Jorge, Denholm, Justin, Duarte, Raquel, Elamin, Seifeldin Eltaeb, Ferrarese, Maurizio, Filippov, Alexey, Ganatra, Shashank, Garcia, Ana, García-García, José-María, Gayoso, Regina, Giraldo Montoya, Angela Maria, Gomez Rosso, Roscio Gomez, Gualano, Gina, Hoefsloot, Wouter, Ilievska-Poposka, Biljana, Jonsson, Jerker, Khimova, Elena, Kuksa, Liga, Kunst, Heinke, Laniado-Laborín, Rafael, Li, Yang, Magis-Escurra, Cecile, Manfrin, Vinicio, Manga, Selene, Marchese, Valentina, Martínez Robles, Elena, Maryandyshev, Andrei, Matteelli, Alberto, Migliori, Giovanni Battista, Mullerpattan, Jai B., Munoz-Torrico, Marcela, Mustafa Hamdan, Hamdan, Nieto Marcos, Magnolia, Noordin, Noorliza Mohamad, Palmero, Domingo Juan, Palmieri, Fabrizio, Payen, Marie-Christine, Piubello, Alberto, Pontali, Emanuele, Pontarelli, Agostina, Quirós, Sarai, Rendon, Adrian, Skrahina, Alena, Šmite, Agnese, Solovic, Ivan, Sotgiu, Giovanni, Souleymane, Mahamadou Bassirou, Spanevello, Antonio, Stošić, Maja, Tadolini, Marina, Tiberi, Simon, Udwadia, Zarir Farokh, van den Boom, Martin, Vescovo, Marisa, Viggiani, Pietro, Visca, Dina, Zhurkin, Dmitry, and Zignol, Matteo

Published
2019
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5. Quality Assessment of Dried Blood Spots from Patients With Tuberculosis from 4 Countries

Author

Zuur, Marlanka A., primary, Veenhof, Herman, additional, Aleksa, Alena, additional, van't Boveneind-Vrubleuskaya, Natascha, additional, Darmawan, Endang, additional, Hasnain, Md Golam, additional, Heysell, Scott K., additional, Jongedijk, Erwin M., additional, Koster, Remco A., additional, Magis-Escurra, Cecile, additional, Martinez, Nilza, additional, Molinas, Gladys, additional, Mondal, Dinesh, additional, Mulyani, Ully A., additional, Perwitasari, Dyah A., additional, Tsivunchyk, Andrej, additional, Touw, Daan J., additional, and Alffenaar, Jan-Willem C., additional

Published
2019
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6. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: first global report

Author

Borisov, Sergey, primary, Danila, Edvardas, additional, Maryandyshev, Andrei, additional, Dalcolmo, Margareth, additional, Miliauskas, Skaidrius, additional, Kuksa, Liga, additional, Manga, Selene, additional, Skrahina, Alena, additional, Diktanas, Saulius, additional, Codecasa, Luigi Ruffo, additional, Aleksa, Alena, additional, Bruchfeld, Judith, additional, Koleva, Antoniya, additional, Piubello, Alberto, additional, Udwadia, Zarir Farokh, additional, Akkerman, Onno W., additional, Belilovski, Evgeny, additional, Bernal, Enrique, additional, Boeree, Martin J., additional, Cadiñanos Loidi, Julen, additional, Cai, Qingshan, additional, Cebrian Gallardo, Jose Joaquín, additional, Dara, Masoud, additional, Davidavičienė, Edita, additional, Forsman, Lina Davies, additional, De Los Rios, Jorge, additional, Denholm, Justin, additional, Drakšienė, Jacinta, additional, Duarte, Raquel, additional, Elamin, Seifeldin Eltaeb, additional, Escobar Salinas, Nadia, additional, Ferrarese, Maurizio, additional, Filippov, Alexey, additional, Garcia, Ana, additional, García-García, José-María, additional, Gaudiesiute, Ieva, additional, Gavazova, Blagovesta, additional, Gayoso, Regina, additional, Gomez Rosso, Roscio, additional, Gruslys, Vygantas, additional, Gualano, Gina, additional, Hoefsloot, Wouter, additional, Jonsson, Jerker, additional, Khimova, Elena, additional, Kunst, Heinke, additional, Laniado-Laborín, Rafael, additional, Li, Yang, additional, Magis-Escurra, Cecile, additional, Manfrin, Vinicio, additional, Marchese, Valentina, additional, Martínez Robles, Elena, additional, Matteelli, Alberto, additional, Mazza-Stalder, Jesica, additional, Moschos, Charalampos, additional, Muñoz-Torrico, Marcela, additional, Mustafa Hamdan, Hamdan, additional, Nakčerienė, Birutė, additional, Nicod, Laurent, additional, Nieto Marcos, Magnolia, additional, Palmero, Domingo Juan, additional, Palmieri, Fabrizio, additional, Papavasileiou, Apostolos, additional, Payen, Marie-Christine, additional, Pontarelli, Agostina, additional, Quirós, Sarai, additional, Rendon, Adrian, additional, Saderi, Laura, additional, Šmite, Agnese, additional, Solovic, Ivan, additional, Souleymane, Mahamadou Bassirou, additional, Tadolini, Marina, additional, van den Boom, Martin, additional, Vescovo, Marisa, additional, Viggiani, Pietro, additional, Yedilbayev, Askar, additional, Zablockis, Rolandas, additional, Zhurkin, Dmitry, additional, Zignol, Matteo, additional, Visca, Dina, additional, Spanevello, Antonio, additional, Caminero, José A., additional, Alffenaar, Jan-Willem, additional, Tiberi, Simon, additional, Centis, Rosella, additional, D'Ambrosio, Lia, additional, Pontali, Emanuele, additional, Sotgiu, Giovanni, additional, and Migliori, Giovanni Battista, additional

Published
2019
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8. Bedaquiline (BQ)-containing regimen at the programmatic level for MDR-TB: preliminary results

Author

Borisov, Sergey E., primary, Dheda, Keertan, additional, Enwerem, Martin, additional, Romero Leyet, Rodolfo, additional, D’Ambrosio, Lia, additional, Centis, Rosella, additional, Sotgiu, Giovanni, additional, Tiberi, Simon, additional, Alffenaar, Jan-Willem, additional, Maryandyshev, Andrey, additional, Belilowski, Evgeny, additional, Ganatra, Shashank, additional, Skrahina, Alena, additional, Akkerman, Onno, additional, Aleksa, Alena, additional, Amale, Rohit, additional, Artsukevich, Janina, additional, Bruchfeld, Judith, additional, Caminero, Jose A., additional, Carpena Martinez, Isabel, additional, Codecasa, Luigi, additional, Dalcolmo, Margareth, additional, Denholm, Justin, additional, Douglas, Paul, additional, Duarte, Raquel, additional, Esmail, Aliasgar, additional, Fadul, Mohammed, additional, Filippov, Alex, additional, Davies Forsman, Lina, additional, Gaga, Mina, additional, Garcia-Fuertes, Julia- Amaranta, additional, Garcia-Garcia, Jose Maria, additional, Gualano, Gina, additional, Jonsson, Jerker, additional, Kunst, Heinke, additional, Lau, Jillian S., additional, Lazaro Mastrapa, Barbara, additional, Lazaro Teran Troya, Jorge, additional, Manga, Selene, additional, Manika, Katerina, additional, González Montaner, Pablo, additional, Mullerpattan, Jai, additional, Oelofse, Suzette, additional, Ortelli, Martina, additional, Palmero, Domingo Juan, additional, Palmieri, Fabrizio, additional, Papalia, Antonella, additional, Papavasileiou, Apostolos, additional, Payen, Marie-Christine, additional, Pontali, Emanuele, additional, Robalo Cordeiro, Carlos, additional, Sadutshang, Tsetan Dorji, additional, Sanukevich, Tatsiana, additional, Solodovnikova, Varvara, additional, Spanevello, Antonio, additional, Topgyal, Sonam, additional, Toscanini, Federica, additional, Tramontana, Adrian, additional, Udwadia, Zarir Farokh, additional, Viggiani, Pietro, additional, White, Veronica, additional, Zumla, Alimuddin, additional, and Migliori, Giovanni Battista, additional

Published
2017
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9. Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study

Author

Borisov, Sergey E., primary, Dheda, Keertan, additional, Enwerem, Martin, additional, Romero Leyet, Rodolfo, additional, D'Ambrosio, Lia, additional, Centis, Rosella, additional, Sotgiu, Giovanni, additional, Tiberi, Simon, additional, Alffenaar, Jan-Willem, additional, Maryandyshev, Andrey, additional, Belilovski, Evgeny, additional, Ganatra, Shashank, additional, Skrahina, Alena, additional, Akkerman, Onno, additional, Aleksa, Alena, additional, Amale, Rohit, additional, Artsukevich, Janina, additional, Bruchfeld, Judith, additional, Caminero, Jose A., additional, Carpena Martinez, Isabel, additional, Codecasa, Luigi, additional, Dalcolmo, Margareth, additional, Denholm, Justin, additional, Douglas, Paul, additional, Duarte, Raquel, additional, Esmail, Aliasgar, additional, Fadul, Mohammed, additional, Filippov, Alexey, additional, Davies Forsman, Lina, additional, Gaga, Mina, additional, Garcia-Fuertes, Julia-Amaranta, additional, García-García, José-María, additional, Gualano, Gina, additional, Jonsson, Jerker, additional, Kunst, Heinke, additional, Lau, Jillian S., additional, Lazaro Mastrapa, Barbara, additional, Teran Troya, Jorge Lazaro, additional, Manga, Selene, additional, Manika, Katerina, additional, González Montaner, Pablo, additional, Mullerpattan, Jai, additional, Oelofse, Suzette, additional, Ortelli, Martina, additional, Palmero, Domingo Juan, additional, Palmieri, Fabrizio, additional, Papalia, Antonella, additional, Papavasileiou, Apostolos, additional, Payen, Marie-Christine, additional, Pontali, Emanuele, additional, Robalo Cordeiro, Carlos, additional, Saderi, Laura, additional, Sadutshang, Tsetan Dorji, additional, Sanukevich, Tatsiana, additional, Solodovnikova, Varvara, additional, Spanevello, Antonio, additional, Topgyal, Sonam, additional, Toscanini, Federica, additional, Tramontana, Adrian R., additional, Farokh Udwadia, Zarir, additional, Viggiani, Pietro, additional, White, Veronica, additional, Zumla, Alimuddin, additional, and Migliori, Giovanni Battista, additional

Published
2017
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10. FATE: the new partnership to Fight Against TB in Central and Eastern Europe

Author

Jagielski, Tomasz, primary, Aleksa, Alena, additional, Bachiyska, Elizabeta, additional, Bakos, Ágnes, additional, Crudu, Valeriu, additional, Dziadek, Jaroslaw, additional, Homolka, Jirí, additional, Homorodean, Daniela, additional, Jansone, Inta, additional, Katalinic-Jankovic, Vera, additional, Krenke, Rafal, additional, Kuzmic, Uroš, additional, Mokrousov, Igor, additional, Nikolayevskyy, Vlad, additional, Nikolenka, Alena, additional, Osmani, Gjyle Mulliqi, additional, Papaventsis, Dimitrios, additional, Pole, Ilva, additional, Porvazník, Igor, additional, Savic, Branislava, additional, Shubladze, Natalia, additional, Solovic, Ivan, additional, Szabó, Nóra, additional, Tafaj, Silva, additional, Ustamujic, Aida, additional, van Ingen, Jakko, additional, Vasiliauskiene, Edita, additional, Yablonsky, Peter K., additional, Zemanova, Ilona, additional, Zhuravlev, Viacheslav, additional, and Žolnir-Dovc, Manca, additional

Published
2017
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11. Safety and tolerability of clarithromycin in the treatment of multidrug-resistant tuberculosis

Author

Van der Paardt, Anne-Fleur Louise, primary, Akkerman, Onno W., additional, Gualano, Gina, additional, Palmieri, Fabrizio, additional, Davies Forsman, Lina, additional, Aleksa, Alena, additional, Tiberi, Simon, additional, de Lange, Wiel C.M., additional, Bolhuis, Mathieu S., additional, Skrahina, Alena, additional, van Soolingen, Dick, additional, Kosterink, Jos G.W., additional, Migliori, Giovanni Battista, additional, van der Werf, Tjip S., additional, and Alffenaar, Jan-Willem C., additional

Published
2017
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12. Faster for less: The new 'shorter' regimen for multidrug-resistant tuberculosis

Author

Sotgiu, Giovanni, Dore, Simone, Gaga, Mina, Gualano, Gina, Kunst, Heinke, Payen, Marie-Christine, Roby Arias, Aurora Jazmín, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Tiberi, Simon, Zumla, Alimuddin, Migliori, Giovanni Battista, D'Ambrosio, Lia, Centis, Rosella, Alffenaar, Jan Willem, Caminero, José Antonio, Arbex, Marcos Abdo, Alarcon Guizado, Valentina, Aleksa, Alena, Sotgiu, Giovanni, Dore, Simone, Gaga, Mina, Gualano, Gina, Kunst, Heinke, Payen, Marie-Christine, Roby Arias, Aurora Jazmín, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Tiberi, Simon, Zumla, Alimuddin, Migliori, Giovanni Battista, D'Ambrosio, Lia, Centis, Rosella, Alffenaar, Jan Willem, Caminero, José Antonio, Arbex, Marcos Abdo, Alarcon Guizado, Valentina, and Aleksa, Alena

Abstract

SCOPUS: le.j, info:eu-repo/semantics/published

Published
2016

13. Comparison of effectiveness and safety of imipenem/clavulanate-versus meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB

Author

Tiberi, Simon, Gualano, Gina, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Alarcon Guizado, Valentina, De Lorenzo, Saverio, Roby Arias, Aurora Jazmín, Scardigli, Anna, Akkerman, Onno O.W., Sotgiu, Giovanni, Aleksa, Alena, Artsukevich, Janina, Auchynka, Vera, Bonini, Eduardo Henrique, Chong Marín, Felix Antonio, Collahuazo López, Lorena, De Vries, Gérard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, D'Ambrosio, Lia, Moschos, Charalampos, Palmieri, Fabrizio, Papavasileiou, Apostolos, Payen, Marie-Christine, Piana, Andrea, Spanevello, Antonio, Vargas Vasquez, Dante, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, Centis, Rosella, Migliori, Giovanni Battista, Arbex, Marcos Abdo, Alarcon Arrascue, Edith, Alffenaar, Jan Willem, Caminero, José Antonio, Gaga, Mina, Tiberi, Simon, Gualano, Gina, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Alarcon Guizado, Valentina, De Lorenzo, Saverio, Roby Arias, Aurora Jazmín, Scardigli, Anna, Akkerman, Onno O.W., Sotgiu, Giovanni, Aleksa, Alena, Artsukevich, Janina, Auchynka, Vera, Bonini, Eduardo Henrique, Chong Marín, Felix Antonio, Collahuazo López, Lorena, De Vries, Gérard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, D'Ambrosio, Lia, Moschos, Charalampos, Palmieri, Fabrizio, Papavasileiou, Apostolos, Payen, Marie-Christine, Piana, Andrea, Spanevello, Antonio, Vargas Vasquez, Dante, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, Centis, Rosella, Migliori, Giovanni Battista, Arbex, Marcos Abdo, Alarcon Arrascue, Edith, Alffenaar, Jan Willem, Caminero, José Antonio, and Gaga, Mina

Abstract

No large study to date has ever evaluated the effectiveness, safety and tolerability of imipenem/clavulanate versus meropenem/clavulanate to treat multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB). The aim of this observational study was to compare the therapeutic contribution of imipenem/clavulanate versus meropenem/clavulanate added to background regimens to treat MDR- and XDR-TB cases. 84 patients treated with imipenem/clavulanate-containing regimens showed a similar median number of antibiotic resistances (8 versus 8) but more fluoroquinolone resistance (79.0% versus 48.9%, p<0.0001) and higher XDR-TB prevalence (67.9% versus 49.0%, p=0.01) in comparison with 96 patients exposed to meropenem/clavulanate-containing regimens. Patients were treated with imipenem/clavulanate- and meropenem/clavulanate-containing regimens for a median (interquartile range) of 187 (60-428) versus 85 (49-156) days, respectively. Statistically significant differences were observed on sputum smear and culture conversion rates (79.7% versus 94.8%, p=0.02 and 71.9% versus 94.8%, p<0.0001, respectively) and on success rates (59.7% versus 77.5%, p=0.03). Adverse events to imipenem/clavulanate and meropenem/clavulanate were reported in 5.4% and 6.5% of cases only. Our study suggests that meropenem/clavulanate is more effective than imipenem/clavulanate in treating MDR/XDR-TB patients., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

14. Effectiveness and safety of meropenem/clavulanate-containing regimens in the treatment of multidrug-resistant tuberculosis

Author

Payen, Marie-Christine, primary, Tiberi, Simon, additional, Sotgiu, Giovanni Sotgiu, additional, D'ambrosio, Lia, additional, Centis, Rosella, additional, Abdo Arbex, Marcos, additional, Alarcon Arrascue, Edith, additional, Alffenaar, Jan Willem, additional, Caminero, Jose A., additional, Gaga, Mina, additional, Gualano, Gina, additional, Skrahina, Alena, additional, Solovic, Yvan, additional, Sulis, Giogia, additional, Tadolini, Marina, additional, Alarcon Guizado, Valentina, additional, De Lorenzo, Saviero, additional, Arias, Aurora, additional, Scardigli, Anna, additional, Akkerman, Onno W., additional, Aleksa, Alena, additional, Artsukevich, Janina, additional, Avchinko, Vera, additional, Bonini, Eduardo Henrique, additional, Chong Marin, Felix Antonio, additional, Collahuazo Lopez, Lorena, additional, de Vries, Gerard, additional, Dore, Simone, additional, Kunst, Heinke, additional, Matteelli, Alberto, additional, Moschos, Charalampos, additional, Palmieri, Fabrizio, additional, Papavasileiou, Apostolos, additional, Piana, Andrea, additional, Spanevello, Antonio, additional, Vargas Vasquez, Dante, additional, Viggiani, Pietro, additional, White, Veronica, additional, Zumla, Alimuddin, additional, and Migliori, Giovanni Battista, additional

Published
2016
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15. Effectiveness and safety of imipenem/clavulanate- versus meropenem/clavulanate-containing regimens in the treatment of multidrug resistant tuberculosis

Author

Tiberi, Simon, primary, Sotgiu, Giovanni, additional, D'Ambrosio, Lia, additional, Centis, Rosella, additional, Arbex, Marcos Abdo, additional, Alarcon Arrascue, Edith, additional, Alffenaar, Jan Willem, additional, Caminero, Jose A., additional, Gaga, Mina, additional, Gualano, Gina, additional, Skrahina, Alena, additional, Solovic, Ivan, additional, Sulis, Giorgia, additional, Tadolini, Marina, additional, Guizado, Valentina Alarcon, additional, De Lorenzo, Saverio, additional, Arias, Aurora Jazmin Roby, additional, Scardigli, Anna, additional, Akkerman, Onno W., additional, Aleksa, Alena, additional, Artsukevich, Janina, additional, Bonini, Eduardo Henrique, additional, Marin, Felix Antonio Chong, additional, Lopez, Lorena Collahuazo, additional, de Vries, Gerard, additional, Dore, Simone, additional, Kunst, Heinke, additional, Matteelli, Alberto, additional, Moschos, Charalampos, additional, Palmieri, Fabrizio, additional, Papavasileiou, Apostolos, additional, Payen, Marie-Christine, additional, Piana, Andrea, additional, Spanevello, Antonio, additional, Vasquez, Dante Vargas, additional, Viggiani, Pietro, additional, White, Veronica, additional, Zumla, Alimuddin, additional, and Migliori, Giovanni Battista, additional

Published
2016
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16. Faster for less: the new “shorter” regimen for multidrug-resistant tuberculosis

Author

Sotgiu, Giovanni, primary, Tiberi, Simon, additional, D'Ambrosio, Lia, additional, Centis, Rosella, additional, Alffenaar, Jan Willem, additional, Caminero, Jose A., additional, Abdo Arbex, Marcos, additional, Alarcon Guizado, Valentina, additional, Aleksa, Alena, additional, Dore, Simone, additional, Gaga, Mina, additional, Gualano, Gina, additional, Kunst, Heinke, additional, Payen, Marie-Christine, additional, Roby Arias, Aurora Jazmín, additional, Skrahina, Alena, additional, Solovic, Ivan, additional, Sulis, Giorgia, additional, Tadolini, Marina, additional, Zumla, Alimuddin, additional, and Migliori, Giovanni Battista, additional

Published
2016
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17. Comparison of effectiveness and safety of imipenem/clavulanate-versusmeropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB

Author

Tiberi, Simon, primary, Sotgiu, Giovanni, additional, D'Ambrosio, Lia, additional, Centis, Rosella, additional, Abdo Arbex, Marcos, additional, Alarcon Arrascue, Edith, additional, Alffenaar, Jan Willem, additional, Caminero, Jose A., additional, Gaga, Mina, additional, Gualano, Gina, additional, Skrahina, Alena, additional, Solovic, Ivan, additional, Sulis, Giorgia, additional, Tadolini, Marina, additional, Alarcon Guizado, Valentina, additional, De Lorenzo, Saverio, additional, Roby Arias, Aurora Jazmín, additional, Scardigli, Anna, additional, Akkerman, Onno W., additional, Aleksa, Alena, additional, Artsukevich, Janina, additional, Auchynka, Vera, additional, Bonini, Eduardo Henrique, additional, Chong Marín, Félix Antonio, additional, Collahuazo López, Lorena, additional, de Vries, Gerard, additional, Dore, Simone, additional, Kunst, Heinke, additional, Matteelli, Alberto, additional, Moschos, Charalampos, additional, Palmieri, Fabrizio, additional, Papavasileiou, Apostolos, additional, Payen, Marie-Christine, additional, Piana, Andrea, additional, Spanevello, Antonio, additional, Vargas Vasquez, Dante, additional, Viggiani, Pietro, additional, White, Veronica, additional, Zumla, Alimuddin, additional, and Migliori, Giovanni Battista, additional

Published
2016
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18. FATE: the new partnership to Fight Against TB in Central and Eastern Europe

Author

Aleksa, Alena, Bachiyska, Elizabeta, Bakos, Ágnes, Crudu, Valeriu, Dziadek, Jaroslaw, Homolka, Jirí, Homorodean, Daniela, Jansone, Inta, Katalinic-Jankovic, Vera, Krenke, Rafal, Kuzmic, Uroš, Mokrousov, Igor, Nikolayevskyy, Vlad, Nikolenka, Alena, Osmani, Gjyle Mulliqi, Papaventsis, Dimitrios, Pole, Ilva, Porvazník, Igor, Savic, Branislava, Shubladze, Natalia, Solovic, Ivan, Szabó, Nóra, Tafaj, Silva, Ustamujic, Aida, van Ingen, Jakko, Vasiliauskiene, Edita, Yablonsky, Peter K., Zemanova, Ilona, Zhuravlev, Viacheslav, Žolnir-Dovc, Manca, and Jagielski, Tomasz

Published
2017
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19. Comparison of effectiveness and safety of imipenem/clavulanate- versus meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB

Author

Fabrizio Palmieri, Aurora Jazmín Roby Arias, Alena Skrahina, Gina Gualano, Giovanni Sotgiu, Dante Vargas Vasquez, Eduardo Henrique Bonini, Marina Tadolini, Gerard de Vries, Saverio De Lorenzo, Jose A. Caminero, Pietro Viggiani, Marcos Abdo Arbex, Valentina Alarcon Guizado, Apostolos Papavasileiou, Lorena Collahuazo López, Simon Tiberi, Simone Dore, Andrea Piana, Anna Scardigli, Vera Auchynka, Marie-Christine Payen, Antonio Spanevello, Felix Antonio Chong Marin, Alena Aleksa, Edith Alarcon Arrascue, Janina Artsukevich, Heinke Kunst, Alberto Matteelli, Onno W. Akkerman, Giorgia Sulis, Alimuddin Zumla, Giovanni Battista Migliori, Lia D'Ambrosio, Ivan Solovic, Jan-Willem C. Alffenaar, Mina Gaga, Charalampos Moschos, Veronica White, Rosella Centis, Tiberi, Simon, Sotgiu, Giovanni, D'Ambrosio, Lia, Centis, Rosella, Arbex, Marcos Abdo, Arrascue, Edith Alarcon, Alffenaar, Jan Willem, Caminero, Jose A., Gaga, Mina, Gualano, Gina, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Guizado, Valentina Alarcon, De Lorenzo, Saverio, Arias, Aurora Jazmín Roby, Scardigli, Anna, Akkerman, Onno W., Aleksa, Alena, Artsukevich, Janina, Auchynka, Vera, Bonini, Eduardo Henrique, Marín, Félix Antonio Chong, López, Lorena Collahuazo, De Vries, Gerard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, Moschos, Charalampo, Palmieri, Fabrizio, Papavasileiou, Apostolo, Payen, Marie-Christine, Piana, Andrea, Spanevello, Antonio, Vasquez, Dante Varga, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, Migliori, Giovanni Battista, and Microbes in Health and Disease (MHD)

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Imipenem, medicine.drug_class, DELAMANID, Antibiotics, Drug resistance, MULTIDRUG-RESISTANT, Meropenem, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, COMPASSIONATE USE, polycyclic compounds, Culture conversion, MEROPENEM-CLAVULANATE, Medicine, 030212 general & internal medicine, business.industry, Medicine (all), DRUG-RESISTANT TUBERCULOSIS, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, EFFICACY, BEDAQUILINE, Multiple drug resistance, 030228 respiratory system, Tolerability, TOLERABILITY, MYCOBACTERIUM-TUBERCULOSIS, Delamanid, business, LINEZOLID SAFETY, medicine.drug
Abstract

No large study to date has ever evaluated the effectiveness, safety and tolerability of imipenem/clavulanateversusmeropenem/clavulanate to treat multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB). The aim of this observational study was to compare the therapeutic contribution of imipenem/clavulanateversusmeropenem/clavulanate added to background regimens to treat MDR- and XDR-TB cases.84 patients treated with imipenem/clavulanate-containing regimens showed a similar median number of antibiotic resistances (8versus8) but more fluoroquinolone resistance (79.0%versus48.9%, pversus49.0%, p=0.01) in comparison with 96 patients exposed to meropenem/clavulanate-containing regimens. Patients were treated with imipenem/clavulanate- and meropenem/clavulanate-containing regimens for a median (interquartile range) of 187 (60–428)versus85 (49–156) days, respectively.Statistically significant differences were observed on sputum smear and culture conversion rates (79.7%versus94.8%, p=0.02 and 71.9%versus94.8%, pversus77.5%, p=0.03). Adverse events to imipenem/clavulanate and meropenem/clavulanate were reported in 5.4% and 6.5% of cases only.Our study suggests that meropenem/clavulanate is more effective than imipenem/clavulanate in treating MDR/XDR-TB patients.

Published
2016

20. Effectiveness and Safety of Imipenem-Clavulanate Added to an Optimized Background Regimen (OBR) Versus OBR Control Regimens in the Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis

Author

Valentina Alarcon Guizado, Giovanni Sotgiu, Alberto Matteelli, Veronica White, Eduardo Henrique Bonini, Marina Tadolini, Mina Gaga, Saverio De Lorenzo, Fabrizio Palmieri, Lorena Collahuazo López, Aurora Jazmín Roby Arias, Rosella Centis, Ivan Solovic, Anna Scardigli, Edith Alarcon Arrascue, Alena Skrahina, Antonio Spanevello, Marie-Christine Payen, Heinke Kunst, Janina Artsukevich, Vera Avchinko, Apostolos Papavasileiou, Giorgia Sulis, Gerard de Vries, Pietro Viggiani, Charalampos Moschos, Lia D'Ambrosio, Onno W. Akkerman, Jan-Willem C. Alffenaar, Simone Dore, Dante Vargas Vasquez, Simon Tiberi, Alimuddin Zumla, Giovanni Battista Migliori, Andrea Piana, Alena Aleksa, Felix Antonio Chong Marin, Jose A. Caminero, Marcos Abdo Arbex, Gina Gualano, Microbes in Health and Disease (MHD), Tiberi, Simon, Sotgiu, Giovanni, D'Ambrosio, Lia, Centis, Rosella, Arbex, Marcos Abdo, Alarcon Arrascue, Edith, Alffenaar, Jan Willem, Caminero, Jose A., Gaga, Mina, Gualano, Gina, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Alarcon Guizado, Valentina, De Lorenzo, Saverio, Roby Arias, Aurora Jazmín, Scardigli, Anna, Akkerman, Onno W., Aleksa, Alena, Artsukevich, Janina, Avchinko, Vera, Bonini, Eduardo Henrique, Chong Marín, Felix Antonio, Collahuazo López, Lorena, De Vries, Gerard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, Moschos, Charalampo, Palmieri, Fabrizio, Papavasileiou, Apostolo, Payen, Marie Christine, Piana, Andrea, Spanevello, Antonio, Vargas Vasquez, Dante, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, and Migliori, Giovanni Battista

Subjects
Infectious Diseases, Microbiology (medical), Medicine (all), Extensively Drug-Resistant Tuberculosis, Treatment outcome, Antitubercular Agents, Microbiology, Antitubercular Agent, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, 030212 general & internal medicine, Clavulanic Acid, METAANALYSIS, OUTCOMES, business.industry, Imipenem, Treatment Outcome, TB, 030228 respiratory system, Extensively Drug-Resistant Tuberculosi, Drug Therapy, Combination, business, Humanities, Human
Abstract

Simon Tiberi, Giovanni Sotgiu, Lia D’Ambrosio, Rosella Centis, Marcos Abdo Arbex, Edith Alarcon Arrascue, Jan Willem Alffenaar, Jose A. Caminero, Mina Gaga, Gina Gualano, Alena Skrahina, Ivan Solovic, Giorgia Sulis, Marina Tadolini, Valentina Alarcon Guizado, Saverio De Lorenzo, Aurora Jazmin Roby Arias, Anna Scardigli, Onno W. Akkerman, Alena Aleksa, Janina Artsukevich, Vera Avchinko, Eduardo Henrique Bonini, Felix Antonio Chong Marin, Lorena Collahuazo Lopez, Gerard de Vries, Simone Dore, Heinke Kunst, Alberto Matteelli, Charalampos Moschos, Fabrizio Palmieri, Apostolos Papavasileiou, Marie-Christine Payen, Andrea Piana, Antonio Spanevello, Dante Vargas Vasquez, Pietro Viggiani, Veronica White, Alimuddin Zumla and Giovanni Battista Migliori

Published
2016

21. Faster for less: The new 'shorter' regimen for multidrug-resistant tuberculosis

Author

Mina Gaga, Rosella Centis, Lia D'Ambrosio, Jan-Willem C. Alffenaar, Giovanni Sotgiu, Aurora Jazmín Roby Arias, Jose A. Caminero, Marcos Abdo Arbex, Alena Skrahina, Valentina Alarcon Guizado, Simon Tiberi, Simone Dore, Alena Aleksa, Marie-Christine Payen, Ivan Solovic, Heinke Kunst, Alimuddin Zumla, Giovanni Battista Migliori, Marina Tadolini, Gina Gualano, Giorgia Sulis, Sotgiu, Giovanni, Tiberi, Simon, D'Ambrosio, Lia, Centis, Rosella, Alffenaar, Jan Willem, Caminero, Jose A., Arbex, Marcos Abdo, Guizado, Valentina Alarcon, Aleksa, Alena, Dore, Simone, Gaga, Mina, Gualano, Gina, Kunst, Heinke, Payen, Marie Christine, Arias, Aurora Jazmín Roby, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Zumla, Alimuddin, Migliori, Giovanni Battista, and Microbes in Health and Disease (MHD)

Subjects
Drug, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, media_common.quotation_subject, Antitubercular Agents, Pharmacology, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, MEROPENEM/CLAVULANATE-CONTAINING REGIMENS, WORLD, Internal medicine, Tuberculosis, Multidrug-Resistant, medicine, Humans, DRUGS, 030212 general & internal medicine, XDR-TB, media_common, biology, business.industry, medicine.disease, biology.organism_classification, Multiple drug resistance, Regimen, 030228 respiratory system, SAFETY, business
Abstract

Evaluation of drug resistances is needed to identify candidates for the shorter regimen in MDR-TB hot spots http://ow.ly/wZV33022VXt

Published
2016

22. Comparison of effectiveness and safety of imipenem/clavulanate- versus meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB.

Author

Tiberi S, Sotgiu G, D'Ambrosio L, Centis R, Abdo Arbex M, Alarcon Arrascue E, Alffenaar JW, Caminero JA, Gaga M, Gualano G, Skrahina A, Solovic I, Sulis G, Tadolini M, Alarcon Guizado V, De Lorenzo S, Roby Arias AJ, Scardigli A, Akkerman OW, Aleksa A, Artsukevich J, Auchynka V, Bonini EH, Chong Marín FA, Collahuazo López L, de Vries G, Dore S, Kunst H, Matteelli A, Moschos C, Palmieri F, Papavasileiou A, Payen MC, Piana A, Spanevello A, Vargas Vasquez D, Viggiani P, White V, Zumla A, and Migliori GB

Subjects
Adult, Cohort Studies, Comparative Effectiveness Research, Drug Resistance, Bacterial, Female, Humans, Male, Meropenem, Middle Aged, Sputum metabolism, Time Factors, Treatment Outcome, Antitubercular Agents administration & dosage, Clavulanic Acid administration & dosage, Extensively Drug-Resistant Tuberculosis drug therapy, Imipenem administration & dosage, Thienamycins administration & dosage, Tuberculosis, Multidrug-Resistant drug therapy
Abstract

No large study to date has ever evaluated the effectiveness, safety and tolerability of imipenem/clavulanate versus meropenem/clavulanate to treat multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB). The aim of this observational study was to compare the therapeutic contribution of imipenem/clavulanate versus meropenem/clavulanate added to background regimens to treat MDR- and XDR-TB cases.84 patients treated with imipenem/clavulanate-containing regimens showed a similar median number of antibiotic resistances (8 versus 8) but more fluoroquinolone resistance (79.0% versus 48.9%, p<0.0001) and higher XDR-TB prevalence (67.9% versus 49.0%, p=0.01) in comparison with 96 patients exposed to meropenem/clavulanate-containing regimens. Patients were treated with imipenem/clavulanate- and meropenem/clavulanate-containing regimens for a median (interquartile range) of 187 (60-428) versus 85 (49-156) days, respectively.Statistically significant differences were observed on sputum smear and culture conversion rates (79.7% versus 94.8%, p=0.02 and 71.9% versus 94.8%, p<0.0001, respectively) and on success rates (59.7% versus 77.5%, p=0.03). Adverse events to imipenem/clavulanate and meropenem/clavulanate were reported in 5.4% and 6.5% of cases only.Our study suggests that meropenem/clavulanate is more effective than imipenem/clavulanate in treating MDR/XDR-TB patients., (Copyright ©ERS 2016.)

Published
2016
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