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1. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Laura Herrera-Hidalgo, Patricia Muñoz, Ana Álvarez-Uría, David Alonso-Menchén, Rafael Luque-Marquez, Encarnación Gutiérrez-Carretero, María Del Carmen Fariñas, Jose Maria Miró, Miguel Angel Goenaga, Luis Eduardo López-Cortés, Basilio Angulo-Lara, Lucia Boix-Palop, Arístides de Alarcón, Fernando Fernández Sánchez, José Mª García de Lomas, Gabriel Rosas, Javier de la Torre Lima, Elena Bereciartua, María José Blanco Vidal, Roberto Blanco, María Victoria Boado, Marta Campaña Lázaro, Alejandro Crespo, Laura Guio Carrión, Mikel Del Álamo Martínez de Lagos, Gorane Euba Ugarte, Ane Josune Goikoetxea, Marta Ibarrola Hierro, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Miguel Montejo, Javier Nieto, David Rodrigo, Regino Rodríguez, Yolanda Vitoria, Roberto Voces, Mª Victoria García López, Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ignacio Álvarez Rodríguez, Harkaitz Azkune Galparsoro, Elisa Berritu Boronat, Mª Jesús Bustinduy Odriozola, Cristina del Bosque Martín, Tomás Echeverría, Alberto Eizaguirre Yarza, Ana Fuentes, Miguel Ángel Goenaga, Muskilda Goyeneche del Río, Ángela Granda Bauza, José Antonio Iribarren, Xabier Kortajarena Urkola, José Ignacio Pérez-Moreiras López, Ainhoa Rengel Jiménez, Karlos Reviejo, Alberto Sáez Berbejillo, Elou Sánchez Haza, Rosa Sebastián Alda, Itziar Solla Ruiz, Irati Unamuno Ugartemendia, Diego Vicente Anza, Iñaki Villanueva Benito, Mar Zabalo Arrieta, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Alberto Bouzas, Brais Castelo, José Cuenca, Laura Gutiérrez, Lucía Ramos, María Rodríguez Mayo, Joaquín Manuel Serrano, Dolores Sousa Regueiro, Francisco Javier Martínez, Mª del Mar Alonso, Beatriz Castro, Teresa Delgado Melian, Javier Fernández Sarabia, Dácil García Rosado, Julia González González, Juan Lacalzada, Lissete Lorenzo de la Peña, Alina Pérez Ramírez, Pablo Prada Arrondo, Fermín Rodríguez Moreno, Antonio Plata Ciezar, José Mª Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Juan Ambrosioni, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Guillermo Cuervo, Carlos Falces, Mariana J Fernández-Pittol, Guillermina Fita, David Fuster, Cristina García de la Mària, Delia García-Pares, Marta Hernández-Meneses, Jaume Llopis Pérez, Francesc Marco, José M. Miró, Asunción Moreno, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Juan M. Pericás, José L. Pomar, José Ramírez, Mercè Roque, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, José M. Tolosana, Bárbara Vidal, Jordi Vila, Iván Adán, David Alonso, Juan Carlos Alonso, Javier Bermejo, Emilio Bouza, Gregorio Cuerpo Caballero, Antonia Delgado Montero, Agustín Estévez, Ramón Fortuny Ribas, Esther Gargallo, Mª Eugenia García Leoni, Ana González Mansilla, Francisco Javier González Moraga, Víctor González Ramallo, Martha Kestler Hernández, Amaia Mari Hualde, Marina Machado, Mercedes Marín, Manuel Martínez-Sellés, Rosa Melero, Diego Monzón, María Olmedo, Álvaro Pedraz, Blanca Pinilla, Ángel Pinto, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Eduardo Sánchez-Pérez, Antonio Segado, Neera Toledo, Maricela Valerio, Pilar Vázquez, Eduardo Verde Moreno, Sofía de la Villa, Isabel Antorrena, Belén Loeches, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Sandra Rosillo, Jesús Agüero Balbín, Cristina Amado Fernández, Carlos Armiñanzas Castillo, Francisco Arnaiz de las Revillas, Manuel Cobo Belaustegui, María Carmen Fariñas, Concepción Fariñas-Álvarez, Marta Fernández Sampedro, Iván García, Claudia González Rico, Laura Gutiérrez-Fernández, Manuel Gutiérrez-Cuadra, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Jorge Calderón Parra, Marta Cobo, Fernando Domínguez, Pablo García Pavía, Ana Fernández Cruz, Antonio Ramos-Martínez, Isabel Sánchez Romero, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Navas, Enrique Oliva, Alejandro del Río, Jorge Rodríguez-Roda Stuart, Soledad Ruiz, Carmen Hidalgo Tenorio, Sergio Sequera, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Juan Gálvez Acebal, Irene Méndez, Isabel Morales, José Antonio Lepe, José López-Haldón, Rafael Luque-Márquez, Guillermo Marín, Antonio Ortiz-Carrellán, Eladio Sánchez-Domínguez, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Estíbaliz Corral Armas, Lara García-Álvarez, José Antonio Oteo, Antonio Barros Membrilla, Antonino Ginel Iglesias, Sara Grillo, Rubén Leta Petracca, Joaquín López-Contreras, María Alba Rivera Martínez, M. Álvarez, A.L. Fernández, Amparo Martínez, A. Prieto, Benito Regueiro, E. Tijeira, Marino Vega, Amaia Aguirre Quiñonero, Ángela Alonso Miñambres, Juan Carlos Gainzarain Arana, Sara González de Alaiza Ortega, Miguel Ángel Morán Rodríguez, Anai Moreno Rodríguez, Zuriñe Ortiz de Zárate, José Joaquín Portu Zapirain, Ester Sáez de Adana Arroniz, Daisy Carolina Sorto Sánchez, Sánchez-Porto Antonio, Úbeda Iglesias Alejandro, José Mª Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, Mª Antonia Sepúlveda, Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Ivan Keituqwa Yañez, Julián Navarro Martínez, Ana Peláez Ballesta, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Mª Cruz Pérez Seco, Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Mª Pilar Palacián Ruiz, Juan Carlos Porres, Begoña Alcaraz Vidal, María Jesús Del Amor Espín, Francisco Buendía, Roberto Jiménez Sánchez, Rosario Mármol, Francisco Martínez, Antonio Meseguer, Beatriz Pérez, Leticia Risco, Zoser Saura, Vanina Silva, Mª Belén Villmarín, Mª Ángels Ribas Blanco, Enrique Ruiz de Gopegui Bordes, Laura Vidal Bonet, Miquel Vives Borràs, Mª Carmen Bellón Munera, Elena Escribano Garaizabal, Antonia Tercero Martínez, Juan Carlos Segura Luque, Cristina Badía, Lucía Boix Palop, Mariona Xercavins, Sónia Ibars, Xerach Bosch, Eloy Gómez Nebreda, Ibalia Horcajada Herrera, Irene Menduiña Gallego, Imanol Pulido, Héctor Marrero Santiago, Isabel de Miguel Martínez, Elena Pisos Álamo, Daniel San Román Sánchez, Jorge Boan Pérez, Eva Mª Aguilar Blanco, Mercedes Catalán González, María Angélica Corres Peiretti, Andrea Eixerés Esteve, Laura Domínguez Pérez, Santiago de Cossío Tejido, Francisco Galván Román, José Antonio García Robles, Francisco López Medrano, Mª Jesús López Gude, Mª Ángeles Orellana Miguel, Patrick Pilkington, Yolanda Revilla Ostalaza, Juan Ruiz Morales, Sebastián Ruiz Solís, Ana Sabín Collado, Marcos Sánchez Fernández, Javier Solera Rallo, Jorge Solís Martín, Francesc Escrihuela-Vidal, Jordi Carratalà, Inmaculada Grau, Carmen Ardanuy, Dámaris Berbel, José Carlos Sánchez Salado, Oriol Alegre, Alejandro Ruiz Majoral, Fabrizio Sbraga, Arnau Blasco, Laura Gracia Sánchez, Iván Sánchez-Rodríguez, Gonzalo Aldamiz, Beatriz Álvarez, Marina Bernal Palacios, Alfonso Cabello Úbeda, Ricardo Fernández Roblas, Rafael Hernández, Victoria Andrea Hortigüela Martín, Andrea Kallmeyer, Cristina Landaeta Kancev, Marta Martín, Miguel Morante Ruiz, Miguel Ángel Navas Lobato, Ana María Pello, Laura Prieto, Marta Tomás Mallebrera, Laura Varela, Mireia de la Peña Triguero, Ruth Esther Figueroa Cerón, Lara Ruiz Gómez, Mireia Ble, Juan Pablo Horcajada Gallego, Antonio José Ginel, Inmaculada López, Alexandra Mas, Antoni Mestres, Lluís Molina, Ramón Serrat, Núria Ribas, Francisca Sánchez, Ana Silverio, Marina Suárez, Luisa Sorlí, Lluís Recasens, Manuel Taurón, María Fernández Regueras, María Ángeles Mantecón Vallejo, José Ángel Pérez Rivera, Nuria Sánchez Mata, Antonia Calvo Cano, Miguel Fajardo Olivares, María Victoria Millán Núñez, and Agustín Muñoz Sanz

Subjects
Infective endocarditis, Methicillin-susceptible Staphylococcus aureus, Cefazolin, Antistaphylococcal penicillin, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P

Published
2023
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2. Evolution of the antimicrobial resistance rates in clinical isolates of Pseudomonas aeruginosa causing invasive infections in the south of Spain

Author

Felipe Fernández-Cuenca, Luis Martínez-Martínez, Álvaro Pascual, Eugenio Garduño, Purificación Hernández Pérez, José Román Muñoz Sanz, Carmen González Velasco, Saray Rodríguez, José M. Navarro Marí, María Dolores Rojo Martín, Marta Álvarez Estévez, Alejandro Peña Monje, Waldo Sánchez Yebra, Carolina Roldán Fontana, Lina Martín Hita, Encarnación Clavijo Frutos, María Gracia Ortega, Begoña Palop Borrás, Pilar Bermúdez Ruiz, José Antonio Lepe, Javier Aznar, M. Carmen Domínguez, Irene Gracia Ahufinger, Fernando Rodríguez, Ana Domínguez Castaño, Manuel Rodríguez Iglesias, Fátima Galán Sánchez, M. Dolores López Prieto, Juan Manuel Sánchez Calvo, José Luis López Barba, and Carmen Martínez Rubio

Subjects
0301 basic medicine, Microbiology (medical), Veterinary medicine, business.industry, 030106 microbiology, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Antimicrobial, Tazobactam, Ciprofloxacin, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Amikacin, polycyclic compounds, Tobramycin, medicine, Colistin, 030212 general & internal medicine, business, medicine.drug, Piperacillin
Abstract

Miembros del Grupo GRAM: Eugenio Garduño, Purificación Hernández Pérez, José Román Muñoz Sanz, Carmen González Velasco, Saray Rodríguez, José M.Navarro Marí, María Dolores Rojo Martín, Marta Álvarez Estévez, Alejandro Peña Monje, Waldo Sánchez Yebra, Carolina Roldán Fontana, Lina Martín Hita, Encarnación Clavijo Frutos, María Gracia Ortega, Begoña Palop Borrás, Pilar Bermúdez Ruiz, José Antonio Lepes, Javier Aznar, M.Carmen Domínguez, Irene Gracia Ahufingeru, Fernando Rodríguez, Ana Domínguez Castaño, Manuel Rodríguez Iglesias, Fátima Galán Sánchez, M.Dolores López Prieto, Juan Manuel Sánchez Calvo, José Luis López Barba, Carmen Martínez Rubio., Introduction: The aim of this study was to determine the antimicrobial resistance rates and their evolution in clinical isolates of Pseudomonas aeruginosa causing invasive infections in the south of Spain between 2012 and 2017. Methods: Retrospective study consisting of the collection of microbiological data from 20 hospitals (14 from Andalucía, 5 from Extremadura and 1 from Ceuta) between 2012 and 2017. The main variables studied were the antimicrobial susceptibility testing system used, interpretation criteria (CLSI or EUCAST) and the rate or percentage of resistant isolates. Results: The most widely used antimicrobial susceptibility testing system was MicroScan (58%). The global resistance rates varied between 25% (ciprofloxacin) and 4% (colistin) using EUCAST, and between 19% (ciprofloxacin and imipenem) and 3% (amikacin) using CLSI. The antimicrobial resistance rates were relatively stable throughout the period 2012-2017. 14% of isolates were MDR and 7% were XDR. Respiratory isolates were more resistant, particularly to ciprofloxacin and colistin, than isolates from urine or blood. Conclusions: The antimicrobial resistance rates in P. aeruginosa are not particularly high in the south of Spain. The highest resistance rates were observed with ciprofloxacin, piperacillin/tazobactam and meropenem, whereas the more active antimicrobials were colistin, tobramycin and amikacin. The highest resistance rates were seen in respiratory isolates. In general, the resistance rates remained stable during the study period for most of the antimicrobials studied.

Published
2020
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3. Psychological distress in women and men living with HIV in Spain: a cross-sectional telephone survey [Postprint]

Author

Dante Culqui Lévano, María J Pérez-Elías, J.L. Gómez-Sirvent, Marta Montero, Alejandro Peña-Monje, Maria Ángeles Rodríguez-Arenas, Jorge del Romero, Cesar Garriga, Lourdes Gutiérrez Trujillo, José Ramón Blanco, Félix Gutiérrez, Instituto de Salud Carlos III, Red de Investigación Cooperativa en Investigación en Sida (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Fondo de Investigación Sanitaria, Instituto de Salud Carlos III - ISCIII, Red Temática Cooperativa de Investigación en Sida (España), and European Regional Development Fund (ERDF/FEDER)

Subjects
Adult, Male, medicine.medical_specialty, Psychopharmacology, Coris, Physical health, HIV Infections, Psychological distress, 030312 virology, Anxiety, Logistic regression, Psychological Distress, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, anxiety disorders, Antiretroviral Therapy, Highly Active, medicine, Humans, Psychological testing, Medical history, 030212 general & internal medicine, Psychiatry, Depression (differential diagnoses), 0303 health sciences, biology, business.industry, Depression, Middle Aged, medicine.disease, biology.organism_classification, Health Surveys, mood disorders, Psychiatry and Mental health, Cross-Sectional Studies, Mood disorders, Spain, Unemployment, depression & mood disorders, Female, medicine.symptom, business
Abstract

Psychological distress includes a broader range of experiences, varying from less severe symptoms of depression and anxiety to severe psychiatric disease. Global estimates for depression and anxiety in 2017 were 3.4% and 3.8%, respectively. While for people living with HIV, global estimates were 16% and 33%, respectively. We aimed to determine the prevalence of psychological distress by gender and associated characteristics in patients living with HIV. A cross-sectional study was conducted within the Spanish HIV Research Network CoRIS. Participants were interviewed by telephone between 2010 and 2014 about their psychological distress, sociodemographics, drug consumption, self-perceived health and combined antiretroviral therapy (cART) adherence. Laboratory tests and medical history details were collected from CoRIS. Logistic regression was used to identify characteristics associated with psychological distress. We interviewed 99 women and 464 men, both living with HIV. A greater proportion of women (51, 51.5%) reported psychological distress than men (179, 38.6%; p

Published
2020

4. Gentamicin may have no effect on mortality of staphylococcal prosthetic valve endocarditis

Author

Antonio Ramos-Martínez, Alejandro Muñoz Serrano, Arístides de Alarcón González, Patricia Muñoz, Ana Fernández-Cruz, Maricela Valerio, María Carmen Fariñas, Manuel Gutiérrez-Cuadra, José Ma Miró, Josefa Ruiz-Morales, Dolores Sousa-Regueiro, José Miguel Montejo, Juan Gálvez-Acebal, Carmen HidalgoTenorio, Fernando Domínguez, Fernando Fernández Sánchez, Mariam Noureddine, Gabriel Rosas, Javier de la Torre Lima, José Aramendi, Elena Bereciartua, Roberto Blanco, María Victoria Boado, Itxasne Cabezón Estébanez, Marta Campaña Lázaro, Josune Goikoetxea, Juan José Goiti, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Miguel Montejo, Javier Nieto, David Rodríguez, Regino Rodríguez, Roberto Voces, Ma Victoria García López, Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ana María Cuende, Tomás Echeverría, Ana Fuerte, Eduardo Gaminde, Miguel Ángel Goenaga, Pedro Idígoras, José Antonio Iribarren, Alberto Izaguirre Yarza, Xabier Kortajarena Urkola, Carlos Reviejo, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Nemesio Álvarez, José María Bravo-Ferrer, Laura Castelo, José Cuenca, Pedro Llinares, Enrique Miguez Rey, María Rodríguez Mayo, Efrén Sánchez, Dolores Sousa Regueiro, Francisco Javier Martínez, Ma del Mar Alonso, Beatriz Castro, Dácil García Rosado, Ma del Carmen Durán, Ma Antonia Miguel Gómez, Juan Lacalzada, Ibrahim Nassar, Antonio Plata Ciezar, José Ma Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Juan Ambrosioni, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Carlos Falces, Guillermina Fita, David Fuster, Cristina García de la Mària, Marta Hernández-Meneses, Jaume Llopis Pérez, Francesc Marco, José M. Miró, Asunción Moreno, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Juan M. Pericás, José L. Pomar, José Ramírez, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, José M. Tolosana, Bárbara Vidal, Jordi Vila, Iván Adán, Javier Bermejo, Emilio Bouza, Gregorio Cuerpo Caballero, Ana Fernández Cruz, Ma Eugenia García Leoni, Víctor González Ramallo, Martha Kestler Hernández, Mercedes Marín, Manuel Martínez-Sellés, Ma Cruz Menárguez, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Blanca Pinilla, Ángel Pinto, Pilar Vázquez, Eduardo Verde Moreno, Isabel Antorrena, Belén Loeches, Alejandro Martín Quirós, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Araceli Saldaña, Jesús Agüero Balbín, Carlos Armiñanzas Castillo, Ana Arnaiz, Francisco Arnaiz de las Revillas, Manuel Cobo Belaustegui, Concepción Fariñas-Álvarez, Rubén Gómez Izquierdo, Iván García, Claudia González Rico, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Pablo García Pavíaz, Jesús Gonzálezz, Beatriz Ordenz, Antonio Ramosz, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Navas, Enrique Oliva, Alejandro del Río, Soledad Ruiz, Carmen Hidalgo Tenorio, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Juan Gálvez Acebal, Irene Méndez, Isabel Morales, Luis Eduardo López-Cortés, Arístides de Alarcón, Emilio García, Juan Luis Haro, José Antonio Lepe, Francisco López, Rafael Luque, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Lara García-Álvarez, José Antonio Oteo, Mercedes Sanz, Natividad de Benito, Mercé Gurguí, Cristina Pacho, Roser Pericas, Guillem Pons, M. Álvarez, A.L. Fernández, Amparo Martínez, A. Prieto, Benito Regueiro, E. Tijeira, Marino Vega, Andrés Canut Blasco, José Cordo Mollar, Juan Carlos Gainzarain Arana, Oscar García Uriarte, Alejandro Martín López, Zuriñe Ortiz de Zárate, José Antonio Urturi Matos, Gloria García Domínguez, Antonio Sánchez-Porto, José Ma Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Anai Moreno Rodríguez, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, Ma Antonia Sepúlveda, Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Pilar Egea Serrano, José Joaquín Hernández Roca, Ivan Keituqwa Yañez, Ana Peláez Ballesta, Víctor Soriano, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Ma Cruz Pérez Seco, Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Ma Pilar Palacián Ruiz, and Juan Carlos Porres

Subjects
Male, 0301 basic medicine, Microbiology (medical), Staphylococcus aureus, medicine.medical_specialty, Prosthesis-Related Infections, 030106 microbiology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Cloxacillin, Vancomycin, Internal medicine, medicine, Humans, Endocarditis, Pharmacology (medical), Prospective Studies, Renal Insufficiency, 030212 general & internal medicine, Aged, Heart Failure, business.industry, Endocarditis, Bacterial, Middle Aged, Staphylococcal Infections, medicine.disease, Anti-Bacterial Agents, Regimen, Infectious Diseases, Heart Valve Prosthesis, Multivariate Analysis, Female, Gentamicin, Gentamicins, Rifampin, business, Complication, Rifampicin, medicine.drug
Abstract

Purpose: To analyze the influence of adding gentamicin to a regimen consisting of β-lactam or vancomycin plus rifampicin on survival in patients suffering from Staphylococcal prosthetic valve endocarditis (SPVE). Methods: From January 2008 to September 2016, 334 patients with definite SPVE were attended in the participating hospitals. Ninety-four patients (28.1%) received treatment based on β-lactam or vancomycin plus rifampicin and were included in the study. Variables were analyzed which related to patient survival during admission, including having received treatment with gentamicin. Results: Seventy-seven (81.9%) were treated with cloxacillin (or vancomycin) plus rifampicin plus gentamicin, and 17 patients (18.1%) received the same regimen without gentamicin. The causative microorganism was Staphylococcus aureus in 40 cases (42.6%) and coagulase-negative staphylococci in 54 cases (57.4%). Overall, 40 patients (42.6%) died during hospital admission, 33 patients (42.9%) in the group receiving gentamicin and 7 patients in the group that did not (41.2%, P = 0.899). Worsening renal function was observed in 42 patients (54.5%) who received gentamicin and in 9 patients (52.9%) who did not (p = 0.904). Heart failure as a complication of endocarditis (OR: 4.58; CI 95%: 1.84–11.42) and not performing surgery when indicated (OR: 2.68; CI 95%: 1.03–6.94) increased mortality. Gentamicin administration remained unrelated to mortality (OR: 1.001; CI 95%: 0.29–3.38) in the multivariable analysis. Conclusions: The addition of gentamicin to a regimen containing vancomycin or cloxacillin plus rifampicin in SPVE was not associated to better outcome.

Published
2018
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5. Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008-2017)

Author

Juan M. Pericàs, Juan Ambrosioni, Patricia Muñoz, Arístides de Alarcón, Martha Kestler, Amaia Mari-Hualde, Asunción Moreno, Miguel Á. Goenaga, M. Carmen Fariñas, Regino Rodríguez-Álvarez, Guillermo Ojeda-Burgos, Juan Gálvez-Acebal, Carmen Hidalgo-Tenorio, Mariam Noureddine, José M. Miró, Fernando Fernández Sánchez, Gabriel Rosas, Javier de la Torre Lima, Roberto Blanco, María Victoria Boado, Marta Campaña Lázaro, Alejandro Crespo, Josune Goikoetxea, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Miguel Montejo, Javier Nieto, David Rodrigo, Regino Rodríguez, Yolanda Vitoria, Roberto Voces, Ma Victoria García López, Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ana María Cuende, Tomás Echeverría, Ana Fuerte, Eduardo Gaminde, Miguel Ángel Goenaga, Pedro Idígoras, José Antonio Iribarren, Alberto Izaguirre Yarza, Xabier Kortajarena Urkola, Carlos Reviejo, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Nemesio Álvarez, José María Bravo-Ferrer, Laura Castelo, José Cuenca, Pedro Llinares, Enrique Miguez Rey, María Rodríguez Mayo, Efrén Sánchez, Dolores Sousa Regueiro, Francisco Javier Martínez, Ma del Mar Alonso, Beatriz Castro, Dácil García Rosado, Ma del Carmen Durán, Ma Antonia Miguel Gómez, Juan Lacalzada, Ibrahim Nassar, Antonio Plata Ciezar, José Ma Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Carlos Falces, Guillermina Fita, David Fuster, Cristina García de la Mària, Delia García-Pares, Marta Hernández-Meneses, Jaume Llopis Pérez, Francesc Marco, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Juan M. Pericás, José L. Pomar, José Ramírez, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, José M. Tolosana, Bárbara Vidal, Jordi Vila, Iván Adán, Javier Bermejo, Emilio Bouza, Daniel Celemín, Gregorio Cuerpo Caballero, Antonia Delgado Montero, Ana García Mansilla, Ma Eugenia García Leoni, Víctor González Ramallo, Martha Kestler Hernández, Amaia Mari Hualde, Mercedes Marín, Manuel Martínez-Sellés, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Blanca Pinilla, Ángel Pinto, Maricela Valerio, Pilar Vázquez, Eduardo Verde Moreno, Isabel Antorrena, Belén Loeches, Alejandro Martín Quirós, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Araceli Saldaña, Jesús Agüero Balbín, Carlos Armiñanzas Castillo, Ana Arnaiz, Francisco Arnaiz de las Revillas, Manuel Cobo Belaustegui, María Carmen Fariñas, Concepción Fariñas-Álvarez, Rubén Gómez Izquierdo, Iván García, Claudia González Rico, Manuel Gutiérrez-Cuadra, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Jorge Calderón Parra, Marta Cobo, Fernando Domínguez, Alberto Fortaleza, Pablo García Pavía, Jesús González, Ana Fernández Cruz, Elena Múñez, Antonio Ramos, Isabel Sánchez Romero, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Navas, Enrique Oliva, Alejandro del Río, Jorge Rodríguez-Roda Stuart, Soledad Ruiz, Carmen Hidalgo Tenorio, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Juan Gálvez Acebal, Irene Méndez, Isabel Morales, Luis Eduardo López-Cortés, Emilio García, Juan Luis Haro, José Antonio Lepe, Francisco López, Rafael Luque, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Antonio Cabrera Villegas, Lara García-Álvarez, José Antonio Oteo, Mercedes Sanz, Natividad de Benito, Mercé Gurguí, Cristina Pacho, Roser Pericas, Guillem Pons, M. Álvarez, A.L. Fernández, Amparo Martínez, A. Prieto, Benito Regueiro, E. Tijeira, Marino Vega, Andrés Canut Blasco, José Cordo Mollar, Juan Carlos Gainzarain Arana, Oscar García Uriarte, Alejandro Martín López, Zuriñe Ortiz de Zárate, José Antonio Urturi Matos, García-Domínguez Gloria, Sánchez-Porto Antonio, José Ma Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Anai Moreno Rodríguez, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, Ma Antonia Sepúlveda, Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Ivan Keituqwa Yañez, Julián Navarro Martínez, Ana Peláez Ballesta, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Ma Cruz Pérez Seco, Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Ma Pilar Palacián Ruiz, Juan Carlos Porres, Begoña Alcaraz Vidal, Nazaret Cobos Trigueros, María Jesús Del Amor Espín, José Antonio Giner Caro, Roberto Jiménez Sánchez, Amaya Jimeno Almazán, Alejandro Ortín Freire, Monserrat Viqueira González, Pere Pericás Ramis, Ma Ángels Ribas Blanco, Enrique Ruiz de Gopegui Bordes, Laura Vidal Bonet, Ma Carmen Bellón Munera, Elena Escribano Garaizabal, Antonia Tercero Martínez, Juan Carlos Segura Luque, Cristina Badía, Lucía Boix Palop, Mariona Xercavins, Sónia Ibars. Eloy Gómez Nebreda, Ibalia Horcajada Herrera, Irene Menduiña Gallego Héctor Marrero Santiago, Isabel de Miguel Martínez, and Elena Pisos Álamo

Subjects
Male, medicine.medical_specialty, Colorectal cancer, Population, Colonoscopy, Enterococcus faecalis, Risk Factors, Internal medicine, medicine, Prevalence, Endocarditis, Humans, education, Gram-Positive Bacterial Infections, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, medicine.diagnostic_test, biology, business.industry, Retrospective cohort study, General Medicine, Endocarditis, Bacterial, Middle Aged, medicine.disease, biology.organism_classification, Infective endocarditis, Cohort, Female, business, Colorectal Neoplasms
Abstract

Objective: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection. Patients and Methods: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en Espana [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31, 2017, from whom data on colonoscopy performance and results were available in 411 patients. Results: One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus. Conclusion: Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.

Published
2019

6. Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse

Author

Isabel Zegri-Reiriz, Arístides de Alarcón, Patricia Muñoz, Manuel Martínez Sellés, Victor González-Ramallo, Jose M. Miro, Carles Falces, Claudia Gonzalez Rico, Xabier Kortajarena Urkola, José Antonio Lepe, Regino Rodriguez Alvarez, Jose Maria Reguera Iglesias, Enrique Navas, Fernando Dominguez, Pablo Garcia-Pavia, Fernando Fernández Sánchez, Mariam Noureddine, Gabriel Rosas, Javier de la Torre Lima, José Aramendi, Elena Bereciartua, María José Blanco, Roberto Blanco, María Victoria Boado, Marta Campaña Lázaro, Alejandro Crespo, Josune Goikoetxea, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Miguel Montejo, Javier Nieto, David Rodrigo, David Rodríguez, Regino Rodríguez, Yolanda Vitoria, Roberto Voces, María Victoria García López, Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ana María Cuende, Tomás Echeverría, Ana Fuerte, Eduardo Gaminde, Miguel Ángel Goenaga, Pedro Idígoras, José Antonio Iribarren, Alberto Izaguirre Yarza, Carlos Reviejo, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Nemesio Álvarez, José María Bravo-Ferrer, Laura Castelo, José Cuenca, Pedro Llinares, Enrique Miguez Rey, María Rodríguez Mayo, Efrén Sánchez, Dolores Sousa Regueiro, Francisco Javier Martínez, María del Mar Alonso, Beatriz Castro, Dácil García Rosado, Mª del Carmen Durán, Mª Antonia Miguel Gómez, Juan Lacalzada, Ibrahim Nassar, Antonio Plata Ciezar, José Mª Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Juan Ambrosioni, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Carlos Falces, Guillermina Fita, David Fuster, Cristina García de la Mària, Marta Hernández-Meneses, Jaume Llopis Pérez, Francesc Marco, José María Miró, Asunción Moreno, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Juan Manuel Pericás, José Luis Pomar, José Ramírez, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, José M. Tolosana, Bárbara Vidal, Jordi Vila, Iván Adán, Javier Bermejo, Emilio Bouza, Daniel Celemín, Gregorio Cuerpo Caballero, Antonia Delgado Montero, Ana Fernández Cruz, Ana García Mansilla, María Eugenia García Leoni, Víctor González Ramallo, Martha Kestler Hernández, Amaia Mari Hualde, Mercedes Marín, Manuel Martínez-Sellés, María Cruz Menárguez, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Blanca Pinilla, Ángel Pinto, Maricela Valerio, Pilar Vázquez, Eduardo Verde Moreno, Isabel Antorrena, Belén Loeches, Alejandro Martín Quirós, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Araceli Saldaña, Jesús Agüero Balbín, Carlos Armiñanzas Castillo, Ana Arnaiz, Francisco Arnaiz de las Revillas, Manuel Cobo Belaustegui, María Carmen Fariñas, Concepción Fariñas-Álvarez, Rubén Gómez Izquierdo, Iván García, Claudia González Rico, Manuel Gutiérrez-Cuadra, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Fernando Domínguez, Pablo García-Pavía, Jesús González Mirelis, Beatriz Orden, Antonio Ramos, Marta Cobo-Marcos, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Oliva, Alejandro del Río, Soledad Ruiz, Carmen Hidalgo Tenorio, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Juan Gálvez Acebal, Irene Méndez, Isabel Morales, Luis Eduardo López-Cortés, Emilio García, Juan Luis Haro, Francisco López, Rafael Luque, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Lara García-Álvarez, José Antonio Oteo, Mercedes Sanz, Natividad de Benito, Mercé Gurguí, Cristina Pacho, Roser Pericas, Guillem Pons, Ángel Luis Fernández, Amparo Martínez, Arturo Prieto, Benito Regueiro, Marino Vega, Andrés Canut Blasco, José Cordo Mollar, Juan Carlos Gainzarain Arana, Oscar García Uriarte, Alejandro Martín López, Zuriñe Ortiz de Zárate, José Antonio Urturi Matos, Gloria García Domínguez, Antonio Sánchez-Porto, José Mª Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Anai Moreno Rodríguez, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, María Antonia Sepúlveda, Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Pilar Egea Serrano, José Joaquín Hernández Roca, Ivan Keituqwa Yañez, Ana Peláez Ballesta, Víctor Soriano, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Mª Cruz Pérez Seco, Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Mª Pilar Palacián Ruiz, Juan Carlos Porres, Begoña Alcaraz Vidal, Nazaret Cobos Trigueros, María Jesús Del Amor Espín, José Antonio Giner Caro, Roberto Jiménez Sánchez, Amaya Jimeno Almazán, Alejandro Ortín Freire, Monserrat Viqueira González, Pere Pericás Ramis, Mª Ángels Ribas Blanco, Enrique Ruiz de Gopegui Bordes, Laura Vidal Bonet, Mª Carmen Bellón Munera, Elena Escribano Garaizabal, Antonia Tercero Martínez, and Juan Carlos Segura Luque

Subjects
Adult, Male, medicine.medical_specialty, bicuspid aortic valve, Enfermedad cardiovascular, Heart Valve Diseases, 030204 cardiovascular system & hematology, Intracardiac injection, 03 medical and health sciences, Tratamiento médico, 0302 clinical medicine, Bicuspid aortic valve, Bicuspid Aortic Valve Disease, medicine, Mitral valve prolapse, Endocarditis, Humans, In patient, 030212 general & internal medicine, Registries, Antibiotic prophylaxis, Antibióticos, Aged, Endocarditis infecciosa, Mitral Valve Prolapse, antibiotic prophylaxis, business.industry, Incidence (epidemiology), Antibiotic Prophylaxis, Middle Aged, medicine.disease, Surgery, Infective endocarditis, Aortic Valve, Válvulas cardíacas, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Background: There is little information concerning infective endocarditis (IE) in patients with bicuspid aortic valve (BAV) or mitral valve prolapse (MVP). Currently, IE antibiotic prophylaxis (IEAP) is not recommended for these conditions. Objectives: This study sought to describe the clinical and microbiological features of IE in patients with BAV and MVP and compare them with those of IE patients with and without IEAP indication, to determine the potential benefit of IEAP in these conditions. Methods: This analysis involved 3,208 consecutive IE patients prospectively included in the GAMES (Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España) registry at 31 Spanish hospitals. Patients were classified as high-risk IE with IEAP indication (high-risk group; n = 1,226), low- and moderate-risk IE without IEAP indication (low/moderate-risk group; n = 1,839), and IE with BAV (n = 54) or MVP (n = 89). Results: BAV and MVP patients had a higher incidence of viridans group streptococci IE than did high-risk group and low/moderate-risk group patients (35.2% and 39.3% vs. 12.1% and 15.0%, respectively; all p < 0.01). A similar pattern was seen for IE from suspected odontologic origin (14.8% and 18.0% vs. 5.8% and 6.0%; all p < 0.01). BAV and MVP patients had more intracardiac complications than did low/moderate-risk group (50% and 47.2% vs. 30.6%, both p < 0.01) patients and were similar to high-risk group patients. Conclusions: IE in patients with BAV and MVP have higher rates of viridans group streptococci IE and IE from suspected odontologic origin than in other IE patients, with a clinical profile similar to that of high-risk IE patients. Our findings suggest that BAV and MVP should be classified as high-risk IE conditions and the case for IEAP should be reconsidered. Sin financiación 18.639 JCR (2018) Q1, 3/136 Cardiac & Cardiovascular Systems 9.280 SJR (2018) Q1, 1/365 Cardiology and Cardiovascular Medicine No data IDR 2018 UEM

Published
2018

7. Sepsityper® for rapid identification of microorganisms from positive blood cultures

Author

Fernando García García, Marta Álvarez-Estévez, Natalia Chueca-Porcuna, Federico García, Alejandro Peña-Monje, Vicente Guillot Suay, and Raquel Camacho-Luque

Subjects
Hemocultivo, General Medicine, Gram negative bacilli, Biology, University hospital, Molecular biology, Implementación, Rapid identification, Blood cultures, Species level, Implementation, Bacteriemia, Malditof MS ®, Sepsityper ®, Gram
Abstract

Nuestro estudio ha evaluado las ventajas de la utilización del kit Sepsityper® para la identificación rápida de microorganismos a partir de hemocultivos positivos, acompañado de la tecnología de espectrometría de masas MALDITOF MS®, en comparación con los métodos tradicionales empleados para el diagnóstico de bacteriemia. Para la identificación del microorganismo en 379 hemocultivos positivos en el Departamento de Microbiología del Hospital Universitario San Cecilio, se aplicó la espectrometría de masas MALDITOF MS® utilizando el sistema Sepsityper® (Bruker) y se comparó con la identificación mediante métodos convencionales (Wider, Vitek II, Api). La correlación de resultados de los dos esquemas diagnósticos fue determinada estadísticamente por el coeficiente de correlación kappa. La distribución de los aislamientos fue de un 24,7 % de Bacilos Gram negativos (BGN) y 75,3 % de microorganismos Cocos Gram positivos (CGP). La concordancia global de resultados fue del 95,8 % en la especie (k = 0,928) y del 98,7 % en el género (k = 0,977), siendo el porcentaje de identificaciones fallidas del 1,3%. Para BGN hubo una concordancia de resultados del 95,2 % (k = 0,928, especie), y 100 % (k = 1, género). Respecto a los CGP, la concordancia fue del 98,2 % en género (k = 0,931), y del 82,5 % (k = 0,627) a nivel de especie. En nuestra experiencia se ha observado una ganancia de al menos 13–23h en la identificación a nivel de especie. La utilización del kit Sepsityper® para la identificación rápida de microorganismos a partir de hemocultivos positivos, acompañado de MALDITOF MS®, muestra una excelente correlación respecto a la identificación realizada a través de la metodología convencional, con una importante disminución del tiempo hasta la identificación., Our study has evaluated the advantages of using Sepsityper® kit for a fast identification of microorganisms from positive blood cultures, along with the mass spectrometry technology MALDITOF-MS®, compared to traditional methods used for diagnosis of bacteremia. To identify the microorganism isolated from the 379 positive blood cultures (BC +) the Department of Microbiology, University Hospital San Cecilio, MALDITOFMS® mass spectrometry along with Sepsityper® (Bruker) were applied and it was compared to the conventional methods for the identification of this organism. The correlation of results between these two diagnostic schemes was statistically determined by kappa correlation coefficient. The distribution of the isolates was 24.7% for Gram negative bacilli (GNB) and 75.3% for Gram-positive cocci (GPC). The overall concordance of results was 95.8% within the species (k = 0.928) and 98.7% within the genus (k = 0.977), with a failed-identification percentage of 1.3%. For GNB there was a concordance of results of 95.2% (k = 0.928, species), and 100% (k = 1, genus). Regarding the GPC, the concordance was 98.2% within the genus (k = 0.931), and 82.5% (k = 0.627) at the species level. According to our experience there was a gain of at least 13-23 hours in the identification of the microorganisms at the species level. The use of Sepsityper® kit for the rapid identification of microorganisms from positive blood cultures, along with MALDITOF-MS®, show an excellent correlation compared to identification made by the conventional methods, with a significant reduction in time until identification.

Published
2014
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8. Carbapenemase detection in Pseudomonas aeruginosa by MALDI-TOF MS mass spectrometry

Author

Marta Álvarez-Estévez, Natalia Chueca-Porcuna, Alejandro Peña-Monje, Raquel Camacho-Luque, and Federico García

Subjects
Carbapenemasas, biology, Detección rápida, Pseudomonas aeruginosa, Chemistry, Pseudomonas, Fast detection, General Medicine, Carbapenemases, medicine.disease_cause, biology.organism_classification, Meropenem, Microbiology, medicine, MALDI-TOF MS, medicine.drug
Abstract

Introducción: Las bacterias gramnegativas, especialmente Pseudomonas, presentan con frecuencia resistencia a múltiples antibióticos incluyendo carbapenemes. La resistencia a carbapanemes se ha incrementado en los últimos años causada por alteraciones de membrana o por la producción de carbapenemasas. Objetivo: Valorar la utilización de la espectrometría de masas MALDI-TOF MS® para la detección de carbapenemasas clase A o B en Pseudomonas aeruginosa. Material y métodos: Partiendo de 12 aislados de Pseudomonas aeruginosa productoras de carbapenemasas clase A o B identificados mediante método de difusión disco-placa, tipificadas usando los discos: meropenem 10µg, meropenem 10µg + ácido borónico, meropenem 10µg + cloxacilina y meropenem 10µg + ácido dipicolínico (Rosco Diagnostica), hemos analizado posibles picos de hidrólisis del meropenem tras la acción de las carbapenemasas mediante espectrometría de masas MALDI-TOF MS®. Como controles negativos se utilizaron 25 cepas de Pseudomonas aeruginosa sensibles a meropenem y 8 cepas de Pseudomonas aeruginosa con impermeabilidad de membrana, no detectables mediante la metodología utilizada. Resultados: De las 12 cepas productoras de carbapenemasas clase A o B, (2/12 clase A, 10/12 clase B), la técnica de espectrometría de masas MALDI-TOF MS® detectó picos de degradación del antibiótico en estudio correspondientes a la presencia de carbapenemasas en 11/12 casos (94.4%). En las cepas usadas como controles negativos, la espectrometría de masas MALDI-TOF MS® indicó la ausencia de carbapenemasas clase A o B en 31/33 (93.9%) casos. Conclusión: La espectrometría de masas MALDI-TOF MS® puede ser una herramienta útil para la confirmación de carbapenemasas clase A y B en Pseudomonas aeruginosa., Introduction: Gram-negative bacteria especially Pseudomonas are resistance to multiple antibiotics including carbapenems. Carbapanemes resistance has increased in recent years caused by alterations of membrane or the production of carbapenemases. Objective: Assess the use of MALDI-TOF MS® mass spectrometry for the detection of carbapenemases class A or B in Pseudomonas aeruginosa. Material and methods: From isolated from Pseudomonas aeruginosa producing carbapenemases 12 class A or B identified by diffusion method disco-plate, classified using disks: meropenem 10μg, meropenem 10μg + boronic acid, meropenem 10μg + cloxacillin and meropenem 10μg + acid dipicolinic (Rosco Diagnostica), we analyzed possible hydrolysis of meropenem peaks after the action of the carbapenemases by MALDI-TOF MS® mass spectrometry. As negative controls were used 25 strains of Pseudomonas aeruginosa sensitive to meropenem and 8 strains of Pseudomonas aeruginosa with waterproof membrane, not detectable by the methodology used. Results: Of the 12 strains producing carbapenemases class A or B, (2/12 class A, 10/12 class B), MALDI-TOF MS® mass spectrometry technique detected peaks of degradation of the antibiotic in study to the presence of carbapenemases in 11/12 cases (94.4%). The strains used as controls negative, MALDI-TOF MS® mass spectrometry indicated the absence of carbapenemases class A or B at 31/33 cases (93.9%). Conclusion: MALDI-TOF MS® mass spectrometry can be a useful tool for the confirmation of carbapenemases class A and B in Pseudomonas aeruginosa.

Published
2015
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9. La espectrometría de masas Maldi-Tof como técnica de rutina para la identificación de micobacterias típicas y atípicas en el laboratorio de microbiología clínica

Author

Alejandro Barbancho, Natalia Montiel, Federico García, Alejandro Peña-Monje, and Raquel Camacho-Luque

Subjects
Clinical microbiology, Desorption ionization, Lowenstein-Jensen, Reverse hybridization, Mycobacteria, General Medicine, Biology, Micobacterias, Malditof MS, Molecular biology
Abstract

Introducción y Objetivo: Del género Mycobacterium se han descrito más de 120 especies de micobacterias diferentes de crecimiento lento y rápido. Estos microorganismos producen una importante morbilidad en humanos, incluyendo infecciones de tipo pulmonar, en la piel y tejidos blandos y enfermedad diseminada siendo el diagnóstico rápido y preciso es de gran importancia. Material y Métodos: La población de estudio de nuestro trabajo fueron 75 aislados de micobacterias procedentes de cultivo en medio sólido Lowenstein-Jensen. El diagnóstico fue realizado mediante técnicas moleculares de PCR e hibridación inversa: GenoType Mycobacterium CM y GenoType Mycobacterium AS. De forma paralela las cepas se identificaron mediante espectrometría de masas MALDITOF MS (Matrix-Assisted Laser Desorption Ionization– Time of Flight Mass Spectrometry). Resultados: La concordancia global de resultados entre la identificación realizada mediante PCR y la tecnología MALDI-TOF fue del 97%, con un coeficiente kappa de correlación de 0.929 (correlación excelente entre 0.081-1.0). Conclusiones: Nuestros resultados indican que es bastante factible incorporar MALDI-TOF MS para la identificación rutinaria de micobacterias en el flujo de trabajo del laboratorio de microbiología clínica., Introduction and aim: in the Mycobacterium genus have been described more than 120 species of Mycobacteria other than growth slow and fast. These microorganisms produce significant morbidity in humans, including type pulmonary infections, skin and soft tissues and disseminated disease being the rapid and precise is of great importance. Material and methods: the study population of our work were 75 isolated Mycobacteria from cultivation in solid Lowenstein-Jensen medium. The diagnosis was made by molecular techniques of PCR and reverse hybridization: GenoType Mycobacterium CM and GenoType Mycobacterium AS. Parallel strains were identified by mass spectrometry MALDITOF MS (Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry). Results: The overall agreement of results between the identification made by PCR and MALDI-TOF technology was 97, with a coefficient of correlation of 0.929 kappa (excellent correlation between 0.081-1.0). Conclusions: Our results indicate that it is quite feasible to incorporate MALDI-TOF MS for routine identification of Mycobacteria in the clinical microbiology laboratory workflow.

Published
2015

10. Comparative activity of tedizolid against clinical isolates of linezolid-resistant coagulase-negative staphylococci and methicillin-resistant Staphylococcus aureus

Author

Santiago Pérez-Parra, Federico García-García, Juan Luis Recio, and Alejandro Peña-Monje

Subjects
0301 basic medicine, business.industry, 030106 microbiology, medicine.disease_cause, Methicillin-resistant Staphylococcus aureus, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Linezolid, medicine, Tedizolid, Coagulase, business
Published
2017
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12. In vitro efficacy of daptomycin and teicoplanin combined with ethanol, clarithromycin or gentamicin as catheter lock solutions

Author

Nieves María Coronado-Álvarez, Alejandro Peña-Monje, Jorge Parra-Ruiz, Diego Parra, José Hernández-Quero, [Parra,D, Coronado-Álvarez,NM, Hernández-Quero,J, Parra-Ruiz,J] Laboratorio de Investigación Antimicrobiana, Hospital Universitario San Cecilio. Instituto de Investigación Biosanitaria de Granada, Granada, Spain. [Peña-Monje,A] Servicio de Microbiología, Hospital Universitario San Cecilio, Granada, Spain. [Hernández-Quero,J, and Parra-Ruiz,J] Servicio de Enfermedades Infecciosas, Hospital Universitario San Cecilio. Instituto de Investigación Biosanitaria de Granada, Granada, Spain.

Subjects
Etanol, Técnicas In vitro, Pharmacology, Central line associated bloodstream infections, Antibiotic lock therapy, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Staphylococcus epidermidis, Quimioterapia combinada, Clarithromycin, Claritromicina, Pruebas de sensibilidad microbiana, biology, Teicoplanin, Biofilm, Gentamicinas, Teicoplanina, Antimicrobial, Anti-Bacterial Agents, Humanos, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests [Medical Subject Headings], Antibacterianos, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::In Vitro Techniques [Medical Subject Headings], Vancomycin, Gentamicin, Drug Therapy, Combination, Coagulase, medicine.drug, Research Article, Catéteres, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [Medical Subject Headings], Microbiology (medical), Phenomena and Processes::Microbiological Phenomena::Biofilms [Medical Subject Headings], Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Gentamicins [Medical Subject Headings], Catheters, Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic::Daptomycin [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Therapy, Combination [Medical Subject Headings], Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Staphylococcaceae::Staphylococcus::Staphylococcus epidermidis [Medical Subject Headings], Microbial Sensitivity Tests, Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Erythromycin::Clarithromycin [Medical Subject Headings], In Vitro Techniques, Microbiology, Daptomycin, medicine, Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial::Drug Resistance, Bacterial::beta-Lactam Resistance::Penicillin Resistance::Methicillin Resistance [Medical Subject Headings], Humans, Vancomicina, Ethanol, biology.organism_classification, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Catheters [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol [Medical Subject Headings], Biofilms, Chemicals and Drugs::Carbohydrates::Glycoconjugates::Glycopeptides::Vancomycin [Medical Subject Headings], Daptomicina, Methicillin Resistance, Gentamicins, Isotonic Solutions, Biofilmes, Resistencia a la meticilina, Chemicals and Drugs::Carbohydrates::Glycoconjugates::Glycopeptides::Teicoplanin [Medical Subject Headings]
Abstract

Journal Article; BACKGROUND Despite widespread use, optimum choice of antimicrobial agents, concentrations, combinations and exposure times have not been determined for antibiotic lock technique (ALT). Our objective was to evaluate the efficacy of different antibiotic combinations using an in vitro model of catheter-related infection. Daptomycin (DAP) 5 mg/mL, teicoplanin (TEC) 5 mg/mL, both alone and combined with gentamicin (GM) 2.5 mg/mL, clarythromycin (CLA) 5 mg/mL or ethanol 35 % were evaluated against four clinical strains of methicillin resistant coagulase negative staphylococci. Lock solutions were renewed every 24 h. RESULTS After 72 h catheters were reincubated with culture media to investigate bacterial regrowth. All antibiotic combinations resulted in significant reductions (p

Published
2015

13. Baja prevalencia de resistencias primarias frente al virus de la hepatitis B en el sur de España

Author

Fernando García-García, Federico García-García, Vicente Guillot-Suay, Alejandro Peña-Monje, Natalia Chueca-Porcuna, and Marta Álvarez Estévez

Subjects
Microbiology (medical)
Abstract

Resumen Introduccion Para decidir si es necesario investigar resistencias primarias en pacientes naive con hepatitis B cronica es necesario conocer su prevalencia. Pacientes y metodos Hemos analizado la secuencia genetica de la polimerasa en 105 pacientes naive. Resultados En 2 pacientes (1,9%) detectamos el cambio rtV173L, mutacion compensatoria para lamivudina, en un caso la mutacion rtI233V y en otro la «mutacion de escape» sG145R. Conclusion Nuestro estudio demuestra que, por el momento, no esta justificado realizar estudio de resistencias frente al VHB en pacientes naive.

Published
2013
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14. Eficacia y seguridad de daptomicina en dosis elevadas (≥ 8mg/kg/día)

Author

Alejandro Peña-Monje, Cristina Tomas-Jiménez, José Hernández-Quero, Jorge Parra-Ruiz, and José Pomares-Mora

Subjects
Microbiology (medical), Gynecology, medicine.medical_specialty, business.industry, medicine, business
Abstract

Resumen Introduccion Se disponen de pocos datos acerca de la seguridad y eficacia de daptomicina en dosis elevadas (> 8 mg/kg/dia). Material y metodos Estudio ambispectivo de todos los pacientes que recibieron daptomicina ≥ 8 mg/kg/dia y de los que se disponia de datos de eficacia y seguridad. Resultados Se incluyo a 69 pacientes, observandose curacion o mejoria en 59 (85,5%). Seis pacientes (8,6%) presentaron elevacion de CPK sin repercusion clinica en ningun caso. Conclusiones La eficacia de daptomicina en dosis ≥ 8 mg/kg/dia es elevada sin que exista toxicidad clinica derivada de su empleo.

Published
2011
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16. Elution kinetics, antimicrobial activity, and mechanical properties of 11 different antibiotic loaded acrylic bone cement

Author

Juan N. Moliz, Ruben Gálvez-López, Alejandro Peña-Monje, Ramón Antelo-Lorenzo, Jorge Parra-Ruiz, José Hernández-Quero, and Juan Guardia-Olmedo

Subjects
Microbiology (medical), Cefotaxime, Time Factors, Cefepime, Microbial Sensitivity Tests, Meropenem, Microbiology, chemistry.chemical_compound, polycyclic compounds, medicine, Escherichia coli, Humans, Polymethyl Methacrylate, Chromatography, High Pressure Liquid, Mechanical Phenomena, Chromatography, Chemistry, Elution, General Medicine, biochemical phenomena, metabolism, and nutrition, Bone cement, Antimicrobial, Anti-Bacterial Agents, Infectious Diseases, Daptomycin, Ertapenem, medicine.drug, Micrococcaceae
Abstract

Antibiotic-loaded acrylic bone cements (ALABC) spacers are routinely used in the treatment of prosthetic joint infections. The objectives of our study were to evaluate different ALABC for elution kinetics, thermal stability, and mechanical properties. A 10 or 20% mixture (w/w) beads of medium viscosity bone cement (DePuy, Inc) and vancomycin (VAN), gentamycin (GM), daptomycin (DAP), moxifloxacin (MOX), rifampicin (RIF), cefotaxime (CTX), cefepime (FEP), amoxicillin clavulanate (AmC), ampicillin (AMP), meropenem (MER), and ertapenem (ERT) were formed and placed into wells filled with phosphate-buffered saline. Antibiotic concentrations were determined using high-performance liquid chromatography. Antimicrobial activity was tested against Micrococcus luteus ATCC 9341 or Escherichia coli ATCC 25922. AmC, AMP, and FEP concentration rapidly decreased after day 2, being almost undetectable at day 4. Sustained and high elution rates were observed with VAN, GM, MOX, and RIF for the 30-day duration of the experiment. DAP, MER, ERT, and CTX elution rates constantly decreased from day 4. All antibiotics tested retained antimicrobial activity proving thermal stability. Mechanical properties of ALABC were maintained except when RIF was used.

Published
2012

17. Activity of linezolid and high-dose daptomycin, alone or in combination, in an in vitro model of Staphylococcus aureus biofilm

Author

Alejandra Bravo-Molina, Alejandro Peña-Monje, José Hernández-Quero, and Jorge Parra-Ruiz

Subjects
Microbiology (medical), Methicillin-Resistant Staphylococcus aureus, In Vitro Techniques, medicine.disease_cause, Microbiology, chemistry.chemical_compound, Pharmacokinetics, Daptomycin, Acetamides, polycyclic compounds, medicine, Humans, Pharmacology (medical), Drug Interactions, Oxazolidinones, Pharmacology, biology, Chemistry, Biofilm, Linezolid, biochemical phenomena, metabolism, and nutrition, Staphylococcal Infections, bacterial infections and mycoses, biology.organism_classification, In vitro, Anti-Bacterial Agents, Infectious Diseases, Staphylococcus aureus, Pharmacodynamics, Biofilms, Bacteria, medicine.drug
Abstract

The aim of the study was to assess the in vitro activity of linezolid and daptomycin, alone and in combination, against three Staphylococcus aureus isolates using a pharmacokinetic/pharmacodynamic (PK/PD) model of biofilm for 3 days.One non-clinical methicillin-resistant S. aureus isolate (N315) and two clinical methicillin-resistant S. aureus isolates were evaluated. Simulated regimens included high-dose daptomycin (10 mg/kg once daily) and linezolid (600 mg twice daily), alone and in combination.Against all three strains, neither linezolid nor daptomycin alone was bactericidal against biofilm-embedded bacteria (BB). Against planktonic bacteria (PB) only daptomycin was bactericidal. In contrast, the combination of linezolid and daptomycin demonstrated greater activity than either of the two agents alone, being bactericidal against both PB and BB, almost reaching the limit of detection at 72 h.In this in vitro PK/PD model of mature biofilms, a combination of linezolid plus daptomycin was more effective than each agent alone, representing another potential option to treat S. aureus biofilm-associated infections.

Published
2012

18. [Low prevalence of hepatitis B virus primary drug resistance in Southern Spain]

Author

Marta, Alvarez Estévez, Natalia, Chueca-Porcuna, Vicente, Guillot-Suay, Alejandro, Peña-Monje, Fernando, García-García, and Federico, García-García

Subjects
Adult, Aged, 80 and over, Male, Hepatitis B virus, Adolescent, Genes, Viral, Mutation, Missense, Gene Products, pol, Middle Aged, Antiviral Agents, Young Adult, Hepatitis B, Chronic, Lamivudine, Spain, Child, Preschool, Drug Resistance, Viral, Prevalence, Humans, Point Mutation, Reverse Transcriptase Inhibitors, Female, Hepatitis B Vaccines, Prospective Studies, Child, Aged
Abstract

To know the prevalence of primary resistance in chronic hepatitis B naïve patients is essential to decide on the need of routine laboratory testing.The genetic sequence of the HBV polymerase from 105naïve patients was analysed.rtV173L, a lamivudine compensatory mutation, was detected in two patients (1.9%), rtI233V in one patient, and another one carried the sG145R vaccine escape mutation.Our study shows that studying HBV resistance in naïve patients should not be recommended in the routine laboratory setting, for the time being.

Published
2012

19. Septic Arthritis Due to Cellulosimicrobium cellulans

Author

Enrique Raya, Alejandro Peña-Monje, Juan Salvatierra, Lara Chaves-Chaparro, César Magro-Checa, José Luis Rosales-Alexander, and Jorge Parra-Ruiz

Subjects
DNA, Bacterial, Male, Microbiology (medical), medicine.medical_specialty, Molecular Sequence Data, Arthritis, Knee Injuries, Case Reports, Biology, DNA, Ribosomal, Cellulosimicrobium cellulans, RNA, Ribosomal, 16S, Internal medicine, Actinomycetales, medicine, Humans, Knee, Foreign Bodies, RNA RIBOSOMAL 16S, Aged, 80 and over, Arthritis, Infectious, Sequence Analysis, DNA, medicine.disease, Magnetic Resonance Imaging, Surgery, Radiography, Debridement, Knee surgery, Septic arthritis, Foreign body, Knee injuries, Actinomycetales Infections
Abstract

Cellulosimicrobium cellulans has been reported as a rare cause of human pathogenesis. Infections mainly occur in immunocompromised patients and very often are associated with a foreign body. We report the first case of septic arthritis caused by C. cellulans in an immunocompetent patient. Our patient suffered a penetrating palm tree thorn injury to his left knee 8 weeks before admission. Although no foreign objects were found, they were suspected because previous reports suggest a frequent association with this microorganism, and open debridament was performed. Removal of foreign bodies related to this organism must be considered a high-priority treatment in these patients to achieve a complete recovery.

Published
2011

20. [Efficacy and safety of high dose (≥8 mg/kg/day) daptomycin]

Author

Jorge, Parra-Ruiz, Alejandro, Peña-Monje, Cristina, Tomás-Jiménez, José, Pomares-Mora, and José, Hernández-Quero

Subjects
Adult, Aged, 80 and over, Male, Daptomycin, Humans, Female, Prospective Studies, Middle Aged, Aged, Anti-Bacterial Agents, Retrospective Studies
Abstract

There is a paucity of data regarding efficacy and safety of high dose (8mg/kg/day) daptomycin.This ambispective study included all patients that received ≥8 mg/kg/day of daptomycin and had efficacy and safety data.Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them.High dose daptomycin shows good efficacy without concerns about toxicity.

Published
2010

21. Endocarditis de rápida evolución

Author

Alejandro Peña Monje, Carlos Santiago Díaz, Federico García, and Carmen Tenorio

Subjects
medicine.medical_specialty, business.industry, Medicine, General Medicine, business, Dermatology
Published
2012
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22. Una imagen contemporánea de la endocarditis enterocócica

Author

Pericàs, Juan M., Jaume Llopis, Patricia Muñoz, Juan Gálvez Acebal, Martha Kestler, Maricela Valerio, Marta Hernández-Meneses, Miguel Goenaga, Manuel Cobo Belaustegui, Miguel Montejo, Guillermo Ojeda-Burgos, Dolores Sousa Regueiro, Arístides de Alarcón, Antonio Ramos-Martínez, Miró, José M., Fernando Fernández Sánchez, Mariam Noureddine, Gabriel Rosas, Javier de la Torre Lima, Roberto Blanco, María Victoria Boado, Marta Campaña Lázaro, Alejandro Crespo, Josune Goikoetxea, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Javier Nieto, David Rodrigo, Regino Rodríguez, Yolanda Vitoria, Roberto Voces, Victoria García López, M., Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ana María Cuende, Tomás Echeverría, Ana Fuerte, Eduardo Gaminde, Miguel Ángel Goenaga, Pedro Idígoras, José Antonio Iribarren, Alberto Izaguirre Yarza, Xabier Kortajarena Urkola, Carlos Reviejo, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Nemesio Álvarez, José María Bravo-Ferrer, Laura Castelo, José Cuenca, Pedro Llinares, Enrique Miguez Rey, María Rodríguez Mayo, Efrén Sánchez, Francisco Javier Martínez, Del Mar Alonso, M., Beatriz Castro, Dácil García Rosado, Del Carmen Durán, M., Antonia Miguel Gómez, M., Juan Lacalzada, Ibrahim Nassar, Antonio Plata Ciezar, Reguera Iglesias, José M., Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Juan Ambrosioni, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Carlos Falces, Guillermina Fita, David Fuster, Cristina García de la Mària, Delia García-Pares, Jaume Llopis Pérez, Francesc Marco, Asunción Moreno, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Pericás, Juan M., Pomar, José L., José Ramírez, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, Tolosana, José M., Bárbara Vidal, Jordi Vila, Iván Adán, Javier Bermejo, Emilio Bouza, Daniel Celemín, Gregorio Cuerpo Caballero, Antonia Delgado Montero, Ana García Mansilla, Eugenia García Leoni, M., Víctor González Ramallo, Martha Kestler Hernández, Amaia Mari Hualde, Mercedes Marín, Manuel Martínez-Sellés, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Blanca Pinilla, Ángel Pinto, Pilar Vázquez, Eduardo Verde Moreno, Isabel Antorrena, Belén Loeches, Alejandro Martín Quirós, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Araceli Saldaña, Jesús Agüero Balbín, Carlos Armiñanzas Castillo, Ana Arnaiz, Francisco Arnaiz de las Revillas, María Carmen Fariñas, Concepción Fariñas-Álvarez, Rubén Gómez Izquierdo, Iván García, Claudia González Rico, Manuel Gutiérrez-Cuadra, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Jorge Calderón Parra, Marta Cobo, Fernando Domínguez, Alberto Fortaleza, Pablo García Pavía, Jesús González, Ana Fernández Cruz, Elena Múñez, Antonio Ramos, Isabel Sánchez Romero, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Navas, Enrique Oliva, Alejandro del Río, Jorge Rodríguez-Roda Stuart, Soledad Ruiz, Carmen Hidalgo Tenorio, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Irene Méndez, Isabel Morales, Luis Eduardo López-Cortés, Emilio García, Juan Luis Haro, José Antonio Lepe, Francisco López, Rafael Luque, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Antonio Cabrera Villegas, Lara García-Álvarez, José Antonio Oteo, Mercedes Sanz, Natividad Benito, Mercé Gurguí, Cristina Pacho, Roser Pericas, Guillem Pons, Álvarez, M., Fernández, A. L., Amparo Martínez, Prieto, A., Benito Regueiro, Tijeira, E., Marino Vega, Andrés Canut Blasco, José Cordo Mollar, Juan Carlos Gainzarain Arana, Oscar García Uriarte, Alejandro Martín López, Zuriñe Ortiz de Zárate, José Antonio Urturi Matos, García Domínguez Gloria, Sánchez Porto Antonio, Arribas Leal, José M., Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Anai Moreno Rodríguez, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, Antonia Sepúlveda, M., Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Ivan Keituqwa Yañez, Julián Navarro Martínez, Ana Peláez Ballesta, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Cruz Pérez Seco, M., Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Pilar Palacián Ruiz, M., Juan Carlos Porres, Begoña Alcaraz Vidal, Nazaret Cobos Trigueros, María Jesús Del Amor Espín, José Antonio Giner Caro, Roberto Jiménez Sánchez, Amaya Jimeno Almazán, Alejandro Ortín Freire, Monserrat Viqueira González, Pere Pericás Ramis, Ángels Ribas Blanco, M., Enrique Ruiz de Gopegui Bordes, Laura Vidal Bonet, Carmen Bellón Munera, M., Elena Escribano Garaizabal, Antonia Tercero Martínez, Juan Carlos Segura Luque, Cristina Badía, Lucía Boix Palop, Mariona Xercavins, Sónia Ibars, Eloy Gómez Nebreda, Ibalia Horcajada Herrera, Irene Menduiña Gallego, Héctor Marrero Santiago, Isabel de Miguel Martínez, Elena Pisos Álamo, Carmen Díaz Pedroche, Fernando Chaves, Santiago de Cossío, Francisco López Medrano, Jesús López, M., Javier Solera, Jorge Solís, Carmen Ardanuy, Guillermo Cuervo Requena, Sara Grillo, and Alejandro Ruiz Majoral

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