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Your search keyword '"Aleinikova, O. V."' showing total 39 results
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39 results on '"Aleinikova, O. V."'

3. Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis

Author

Albert, M. H., Slatter, M. A., Gennery, A. R., Gungor, T., Bakunina, K., Markovitch, B., Hazelaar, S., Sirait, T., Courteille, V., Aiuti, A., Aleinikova, O. V., Balashov, D., Bernardo, M. E., Bodova, I., Bruno, B., Cavazzana, M., Chiesa, R., Fischer, A., Hauck, F., Ifversen, M., Kalwak, K., Klein, C., Kulagin, A., Kupesiz, A., Kuskonmaz, B., Lindemans, C. A., Locatelli, Franco, Lum, S. H., Maschan, A., Meisel, R., Moshous, D., Porta, F., Sauer, M. G., Sedlacek, P., Schulz, A., Suarez, F., Vallee, T. C., Winiarski, J. H., Zecca, M., Neven, B., Veys, P., Lankester, A. C., Locatelli F. (ORCID:0000-0002-7976-3654), Albert, M. H., Slatter, M. A., Gennery, A. R., Gungor, T., Bakunina, K., Markovitch, B., Hazelaar, S., Sirait, T., Courteille, V., Aiuti, A., Aleinikova, O. V., Balashov, D., Bernardo, M. E., Bodova, I., Bruno, B., Cavazzana, M., Chiesa, R., Fischer, A., Hauck, F., Ifversen, M., Kalwak, K., Klein, C., Kulagin, A., Kupesiz, A., Kuskonmaz, B., Lindemans, C. A., Locatelli, Franco, Lum, S. H., Maschan, A., Meisel, R., Moshous, D., Porta, F., Sauer, M. G., Sedlacek, P., Schulz, A., Suarez, F., Vallee, T. C., Winiarski, J. H., Zecca, M., Neven, B., Veys, P., Lankester, A. C., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for patients affected by Wiskott-Aldrich syndrome (WAS). Reported HSCT outcomes have improved over time with respect to overall survival, but some studies have identified older age and HSCT from alternative donors as risk factors predicting poorer outcome. We analyzed 197 patients undergoing transplant at European Society for Blood and Marrow Transplantation centers between 2006 and 2017 who received conditioning as recommended by the Inborn Errors Working Party (IEWP): either busulfan (n = 103) or treosulfan (n = 94) combined with fludarabine ± thiotepa. After a median follow-up post-HSCT of 44.9 months, 176 patients were alive, resulting in a 3-year overall survival of 88.7% and chronic graft-versus-host disease (GVHD)-free survival (events include death, graft failure, and severe chronic GVHD) of 81.7%. Overall survival and chronic GVHD-free survival were not significantly affected by conditioning regimen (busulfan- vs treosulfan-based), donor type (matched sibling donor/matched family donor vs matched unrelated donor/mismatched unrelated donor vs mismatched family donor), or period of HSCT (2006-2013 vs 2014-2017). Patients aged <5 years at HSCT had a significantly better overall survival. The overall cumulative incidences of grade III to IV acute GVHD and extensive/moderate/severe chronic GVHD were 6.6% and 2.1%, respectively. Patients receiving treosulfan-based conditioning had a higher incidence of graft failure and mixed donor chimerism and more frequently underwent secondary procedures (second HSCT, unconditioned stem cell boost, donor lymphocyte infusion, or splenectomy). In summary, HSCT for WAS with conditioning regimens currently recommended by IEWP results in excellent survival and low rates of GVHD, regardless of donor or stem cell source, but age ≥5 years remains a risk factor for overall survival.

Published
2022

7. Geographical Distribution, Incidence, Malignancies, and Outcome of 136 Eastern Slavic Patients With Nijmegen Breakage Syndrome and NBN Founder Variant c.657_661del5

Author

Sharapova, S. O., Pashchenko, O. E., Bondarenko, A. V., Vakhlyarskaya, S. S., Prokofjeva, T., Fedorova, A. S., Savchak, I., Mareika, Y., Valiev, T. T., Popa, A., Tuzankina, I. A., Vlasova, E. V., Sakovich, I. S., Polyakova, E. A., Rumiantseva, N. V., Naumchik, I. V., Kulyova, S. A., Aleshkevich, S. N., Golovataya, E. I., Minakovskaya, N. V., Belevtsev, M. V., Latysheva, E. A., Latysheva, T. V., Beznoshchenko, A. G., Akopyan, H., Makukh, H., Kozlova, O., Varabyou, D. S., Ballow, M., Ong, M. -S., Walter, J. E., Kondratenko, I. V., Kostyuchenko, L. V., Aleinikova, O. V., Sharapova, S. O., Pashchenko, O. E., Bondarenko, A. V., Vakhlyarskaya, S. S., Prokofjeva, T., Fedorova, A. S., Savchak, I., Mareika, Y., Valiev, T. T., Popa, A., Tuzankina, I. A., Vlasova, E. V., Sakovich, I. S., Polyakova, E. A., Rumiantseva, N. V., Naumchik, I. V., Kulyova, S. A., Aleshkevich, S. N., Golovataya, E. I., Minakovskaya, N. V., Belevtsev, M. V., Latysheva, E. A., Latysheva, T. V., Beznoshchenko, A. G., Akopyan, H., Makukh, H., Kozlova, O., Varabyou, D. S., Ballow, M., Ong, M. -S., Walter, J. E., Kondratenko, I. V., Kostyuchenko, L. V., and Aleinikova, O. V.

Abstract

Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and a high predisposition to lymphoid malignancies. The majority of NBS patients are identified with a homozygous five base pair deletion in the Nibrin (NBN) gene (c.657_661del5, p.K219fsX19) with a founder effect observed in Caucasian European populations, especially of Slavic origin. We present here an analysis of a cohort of 136 NBS patients of Eastern Slav origin across Belarus, Ukraine, Russia, and Latvia with a focus on understanding the geographic distribution, incidence of malignancy, and treatment outcomes of this cohort. Our analysis shows that Belarus had the highest prevalence of NBS (2.3 per 1,000,000), followed by Ukraine (1.3 per 1,000,000), and Russia (0.7 per 1,000,000). Of note, the highest concentration of NBS cases was observed in the western regions of Belarus and Ukraine, where NBS prevalence exceeds 20 cases per 1,000,000 people, suggesting the presence of an “Eastern Slavic NBS hot spot.” The median age at diagnosis of this cohort ranged from 4 to 5 years, and delay in diagnosis was more pervasive in smaller cities and rural regions. A total of 62 (45%) patients developed malignancies, more commonly in males than females (55.2 vs. 34.2%; p=0.017). In 27 patients, NBS was diagnosed following the onset of malignancies (mean age: 8 years). Malignancies were mostly of lymphoid origin and predominantly non-Hodgkin lymphoma (NHL) (n=42, 68%); 38% of patients had diffuse large B-cell lymphoma. The 20-year overall survival rate of patients with malignancy was 24%. However, females with cancer experienced poorer event-free survival rates than males (16.6% vs. 46.8%, p=0.036). Of 136 NBS patients, 13 underwent hematopoietic stem cell transplantation (HSCT) with an overall survival of 3.5 years following treatment (range: 1 to 14 years). Indications for HSCT included malignancy (n=7) and immunodeficiency (n=6). Overall, 9% of patients in this cohort reac

Published
2021

8. Prognostic significance of various 11q23/KMT2A rearrangements in infants with acute lymphoblastic leuekemia

Author

Tsaur, G. A., primary, Riger, T. O., additional, Popov, A. M., additional, Kustanovich, A. M., additional, Olshanskaya, Yu. V., additional, Nasedkina, T. V., additional, Solodovnikov, A. G., additional, Shorikov, E. V., additional, Demina, A. S., additional, Plekhanova, O. M., additional, Nokhrina, E. S., additional, Verzhbitskaya, T. Yu., additional, Streneva, O. V., additional, Makarova, O. V., additional, Arakaev, O. R., additional, Seveliev, L. I., additional, Aleinikova, O. V., additional, Lapotentova, E. S., additional, Myakova, N. V., additional, Fominykh, V. V., additional, Kondratchik, K. L., additional, Boichenko, E. G., additional, Ponomareva, N. I., additional, Karachunskiy, A. I., additional, Roumiantsev, A. G., additional, and Fechina, L. G., additional

Published
2021
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20. Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

Author

Bonaventure, Audrey, Harewood, Rhea, Stiller, Charles A, Gatta, Gemma, Clavel, Jacqueline, Stefan, Daniela C, Carreira, Helena, Spika, Devon, Marcos Gragera, Rafael, Peris Bonet, Rafael, Piñeros, Marion, Sant, Milena, Kuehni, Claudia E, Murphy, Michael F. G, Coleman, Michel P, Allemani, Claudia, Bouzbid, S., Hamdi Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S. H., El Mistiri, M. M., Bayo, S., Malle, B., Manraj, S. S., Sewpaul Sungkur, R., Fabowale, Null, Ogunbiyi, O. J., Bradshaw, D., Somdyala, N. I. M., Stefan, D. C., Abdel Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M. S., Laura, E. A., Espinola, S. B., Calabrano, G. H., Carballo Quintero, B., Fita, R., Garcilazo, D. A., Giacciani, P. L., Diumenjo, M. C., Laspada, W. D., Green, M. A., Lanza, M. F., Ibañez, S. G., Lima, C. A., de Oliveira, E. Lobo, Daniel, C., Scandiuzzi, C., De Souza, P. C. F., Melo, C. D., Del Pino, K., Laporte, C., Curado, M. P., de Oliveira, J. C., Veneziano, C. L. A., Veneziano, D. B., Alexandre, T. S., Verdugo, A. S., Azevedo e. Silva, G., Galaz, J. C., Moya, J. A., Herrmann, D. A., Vargas, S., Herrera, V. M., Uribe, C. J., Bravo, L. E., Arias Ortiz, N. E., Jurado, D. M., Yépez, M. C., Galán, Y. H., Torres, P., Martínez Reyes, F., Pérez Meza, M. L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J. G., Torres Cintrón, C. R., Tortolero Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A. J., Woods, R. R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F. R., Ryan, S., Hannah, H., Dewar, R. A. D., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D. E., Mcclure, C., Vriends, K. A., Bertrand, C., Louchini, R., Robb, K. I., Stuart Panko, H., Demers, S., Wright, S., George, J. T., Shen, X., Brockhouse, J. T., O'Brien, D. K., Ward, K. C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A. G., Vigneau, F., Mackinnon, J. A., Wohler, B., Bayakly, A. R., Clarke, C. A., Glaser, S. L., West, D., Green, M. D., Hernandez, B. Y., Johnson, C. J., Jozwik, D., Charlton, M. E., Lynch, C. F., Huang, B., Tucker, T. C., Deapen, D., Liu, L., Hsieh, M. C., X. C., Wu, Stern, K., Gershman, S. T., Knowlton, R. C., Alverson, J., Copeland, G. E., Rogers, D. B., Lemons, D., Williamson, L. L., Hood, M., Hosain, G. M., Rees, J. R., Pawlish, K. S., Stroup, A., Key, C., Wiggins, C., Kahn, A. R., Schymura, M. J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S. S., Rubertone, J. J., Slack, S. J., Fulton, J. P., Rousseau, D. L., Janes, T. A., Schwartz, S. M., Bolick, S. W., Hurley, D. M., Richards, J., Whiteside, M. A., Nogueira, L. M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D. G., Cheteri, MB Keitheri, Farley, S., Hudson, A. G., Borchers, R., Stephenson, L., Espinoza, J. R., Weir, H. K., Edwards, B. K., Wang, N., Yang, L., Chen, J. S., Song, G. H., X. P., Gu, Zhang, P., H. M., Ge, Zhao, D. L., Zhang, J. H., Zhu, F. D., Tang, J. G., Shen, Y., Wang, J., Q. L., Li, Yang, X. P., Dong, J., Li, W., Cheng, L. P., Chen, J. G., Huang, Q. H., Huang, S. Q., Guo, G. P., Wei, K., Chen, W. Q., Zeng, H., Demetriou, A. V., Pavlou, P., Mang, W. K., Ngan, K. C., Kataki, A. C., Krishnatreya, M., Jayalekshmi, P. A., Sebastian, P., Sapkota, S. D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan Boker, L., Silverman, B. G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Pathy, N. Bhoo, Chimedsuren, O., Tuvshingerel, S., Al Khater, A. H. M., Al Eid, H., Jung, K. W., Won, Y. J., Chiang, C. J., Lai, M. S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S. L., Sriplung, H., Eser, S., Yakut, C. I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A. A., Aleinikova, O. V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A. M., Faivre, J., Guizard, A. V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A. S., Daoulas, M., Clavel, J., Le Guyader Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S. R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R. A., Kumar, V., Ólafsdóttir, E. J., Tryggvadóttir, L., Comber, H., Walsh, P. M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M. F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, MILENA MARIA, Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M. L., Tisano, F., Fanetti, A. C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M. A., Piffer, S., Rosso, S., Sacchetto, Lidia, Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A. P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann Sroka, A., Trojanowski, M., Gózdz, S., Mezyk, R., Gradalska Lampart, M., Radziszewska, A. U., Didkowska, J. A., Wojciechowska, U., Blaszczyk, J., Kepska, K., Bielska Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R. A., Bastos, J., Silva, M. A., Antunes, L., Bento, M. J., Mayer da Silva, A., Miranda, A., Coza, D., Todescu, A. I., Valkov, M. Y., Adamcik, J., Safaei Diba, C., Primic Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J. R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J. M., Marcos, A. I., Marcos Gragera, R., Vilardell Gil, M. L., Molina, E., Sánchez, M. J., Sureda, P. Franch, Montserrat, M. Ramos, Chirlaque, M. D., Navarro, C., Ardanaz, E. E., Moreno Iribas, C. C., Fernández Delgado, R., Peris Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S. M., Herrmann, C., Bulliard, J. L., Maspoli Conconi, M., Frick, H., Kuehni, C. E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S. I., Matthes, K. L., Rashbass, J., Stiller, C. A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R. J., Brewster, D. H., Huws, D. W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M. P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšic, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Murphy, M. F. G., Chalker, E., Newman, L., Baker, D., Soeberg, M. J., Aitken, J., Scott, C., Stokes, B. C., Venn, A., Farrugia, H., Giles, G. G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Latorre, M. R. D. O., and Tanaka, L. F.

Subjects
Hematology
Published
2017

22. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author

Allemani, Claudia, primary, Matsuda, Tomohiro, additional, Di Carlo, Veronica, additional, Harewood, Rhea, additional, Matz, Melissa, additional, Nikšić, Maja, additional, Bonaventure, Audrey, additional, Valkov, Mikhail, additional, Johnson, Christopher J, additional, Estève, Jacques, additional, Ogunbiyi, Olufemi J, additional, Azevedo e Silva, Gulnar, additional, Chen, Wan-Qing, additional, Eser, Sultan, additional, Engholm, Gerda, additional, Stiller, Charles A, additional, Monnereau, Alain, additional, Woods, Ryan R, additional, Visser, Otto, additional, Lim, Gek Hsiang, additional, Aitken, Joanne, additional, Weir, Hannah K, additional, Coleman, Michel P, additional, Bouzbid, S, additional, Hamdi-Chérif, M, additional, Zaidi, Z, additional, Meguenni, K, additional, Regagba, D, additional, Bayo, S, additional, Cheick Bougadari, T, additional, Manraj, S S, additional, Bendahhou, K, additional, Fabowale, A, additional, Bradshaw, D, additional, Somdyala, N I M, additional, Kumcher, I, additional, Moreno, F, additional, Calabrano, G H, additional, Espinola, S B, additional, Carballo Quintero, B, additional, Fita, R, additional, Diumenjo, M C, additional, Laspada, W D, additional, Ibañez, S G, additional, Lima, C A, additional, De Souza, P C F, additional, Del Pino, K, additional, Laporte, C, additional, Curado, M P, additional, de Oliveira, J C, additional, Veneziano, C L A, additional, Veneziano, D B, additional, Latorre, M R D O, additional, Tanaka, L F, additional, Rebelo, M S, additional, Santos, M O, additional, Galaz, J C, additional, Aparicio Aravena, M, additional, Sanhueza Monsalve, J, additional, Herrmann, D A, additional, Vargas, S, additional, Herrera, V M, additional, Uribe, C J, additional, Bravo, L E, additional, Garcia, L S, additional, Arias-Ortiz, N E, additional, Morantes, D, additional, Jurado, D M, additional, Yépez Chamorro, M C, additional, Delgado, S, additional, Ramirez, M, additional, Galán Alvarez, Y H, additional, Torres, P, additional, Martínez-Reyes, F, additional, Jaramillo, L, additional, Quinto, R, additional, Castillo, J, additional, Mendoza, M, additional, Cueva, P, additional, Yépez, J G, additional, Bhakkan, B, additional, Deloumeaux, J, additional, Joachim, C, additional, Macni, J, additional, Carrillo, R, additional, Shalkow Klincovstein, J, additional, Rivera Gomez, R, additional, Poquioma, E, additional, Tortolero-Luna, G, additional, Zavala, D, additional, Alonso, R, additional, Barrios, E, additional, Eckstrand, A, additional, Nikiforuk, C, additional, Noonan, G, additional, Turner, D, additional, Kumar, E, additional, Zhang, B, additional, McCrate, F R, additional, Ryan, S, additional, MacIntyre, M, additional, Saint-Jacques, N, additional, Nishri, D E, additional, McClure, C A, additional, Vriends, K A, additional, Kozie, S, additional, Stuart-Panko, H, additional, Freeman, T, additional, George, J T, additional, Brockhouse, J T, additional, O'Brien, D K, additional, Holt, A, additional, Almon, L, additional, Kwong, S, additional, Morris, C, additional, Rycroft, R, additional, Mueller, L, additional, Phillips, C E, additional, Brown, H, additional, Cromartie, B, additional, Schwartz, A G, additional, Vigneau, F, additional, Levin, G M, additional, Wohler, B, additional, Bayakly, R, additional, Ward, K C, additional, Gomez, S L, additional, McKinley, M, additional, Cress, R, additional, Green, M D, additional, Miyagi, K, additional, Ruppert, L P, additional, Lynch, C F, additional, Huang, B, additional, Tucker, T C, additional, Deapen, D, additional, Liu, L, additional, Hsieh, M C, additional, Wu, X C, additional, Schwenn, M, additional, Gershman, S T, additional, Knowlton, R C, additional, Alverson, G, additional, Copeland, G E, additional, Bushhouse, S, additional, Rogers, D B, additional, Jackson-Thompson, J, additional, Lemons, D, additional, Zimmerman, H J, additional, Hood, M, additional, Roberts-Johnson, J, additional, Rees, J R, additional, Riddle, B, additional, Pawlish, K S, additional, Stroup, A, additional, Key, C, additional, Wiggins, C, additional, Kahn, A R, additional, Schymura, M J, additional, Radhakrishnan, S, additional, Rao, C, additional, Giljahn, L K, additional, Slocumb, R M, additional, Espinoza, R E, additional, Khan, F, additional, Aird, K G, additional, Beran, T, additional, Rubertone, J J, additional, Slack, S J, additional, Garcia, L, additional, Rousseau, D L, additional, Janes, T A, additional, Schwartz, S M, additional, Bolick, S W, additional, Hurley, D M, additional, Whiteside, M A, additional, Miller-Gianturco, P, additional, Williams, M A, additional, Herget, K, additional, Sweeney, C, additional, Johnson, A T, additional, Keitheri Cheteri, M B, additional, Migliore Santiago, P, additional, Blankenship, S E, additional, Farley, S, additional, Borchers, R, additional, Malicki, R, additional, Espinoza, J R, additional, Grandpre, J, additional, Wilson, R, additional, Edwards, B K, additional, Mariotto, A, additional, Lei, Y, additional, Wang, N, additional, Chen, J S, additional, Zhou, Y, additional, He, Y T, additional, Song, G H, additional, Gu, X P, additional, Mei, D, additional, Mu, H J, additional, Ge, H M, additional, Wu, T H, additional, Li, Y Y, additional, Zhao, D L, additional, Jin, F, additional, Zhang, J H, additional, Zhu, F D, additional, Junhua, Q, additional, Yang, Y L, additional, Jiang, C X, additional, Biao, W, additional, Wang, J, additional, Li, Q L, additional, Yi, H, additional, Zhou, X, additional, Dong, J, additional, Li, W, additional, Fu, F X, additional, Liu, S Z, additional, Chen, J G, additional, Zhu, J, additional, Li, Y H, additional, Lu, Y Q, additional, Fan, M, additional, Huang, S Q, additional, Guo, G P, additional, Zhaolai, H, additional, Wei, K, additional, Zeng, H, additional, Demetriou, A V, additional, Mang, W K, additional, Ngan, K C, additional, Kataki, A C, additional, Krishnatreya, M, additional, Jayalekshmi, P A, additional, Sebastian, P, additional, Nandakumar, A, additional, Malekzadeh, R, additional, Roshandel, G, additional, Keinan-Boker, L, additional, Silverman, B G, additional, Ito, H, additional, Nakagawa, H, additional, Sato, M, additional, Tobori, F, additional, Nakata, I, additional, Teramoto, N, additional, Hattori, M, additional, Kaizaki, Y, additional, Moki, F, additional, Sugiyama, H, additional, Utada, M, additional, Nishimura, M, additional, Yoshida, K, additional, Kurosawa, K, additional, Nemoto, Y, additional, Narimatsu, H, additional, Sakaguchi, M, additional, Kanemura, S, additional, Naito, M, additional, Narisawa, R, additional, Miyashiro, I, additional, Nakata, K, additional, Sato, S, additional, Yoshii, M, additional, Oki, I, additional, Fukushima, N, additional, Shibata, A, additional, Iwasa, K, additional, Ono, C, additional, Nimri, O, additional, Jung, K W, additional, Won, Y J, additional, Alawadhi, E, additional, Elbasmi, A, additional, Ab Manan, A, additional, Adam, F, additional, Sanjaajmats, E, 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Grosclaude, P, additional, Bossard, N, additional, Uhry, Z, additional, Bray, F, additional, Piñeros, M, additional, Stabenow, R, additional, Wilsdorf-Köhler, H, additional, Eberle, A, additional, Luttmann, S, additional, Löhden, I, additional, Nennecke, A L, additional, Kieschke, J, additional, Sirri, E, additional, Emrich, K, additional, Zeissig, S R, additional, Holleczek, B, additional, Eisemann, N, additional, Katalinic, A, additional, Asquez, R A, additional, Kumar, V, additional, Petridou, E, additional, Ólafsdóttir, E J, additional, Tryggvadóttir, L, additional, Clough-Gorr, K, additional, Walsh, P M, additional, Sundseth, H, additional, Mazzoleni, G, additional, Vittadello, F, additional, Coviello, E, additional, Cuccaro, F, additional, Galasso, R, additional, Sampietro, G, additional, Giacomin, A, additional, Magoni, M, additional, Ardizzone, A, additional, D'Argenzio, A, additional, Castaing, M, additional, Grosso, G, additional, Lavecchia, A M, additional, Sutera Sardo, A, additional, Gola, G, additional, Gatti, L, additional, Ricci, P, additional, Ferretti, S, additional, Serraino, D, additional, Zucchetto, A, additional, Celesia, M V, additional, Filiberti, R A, additional, Pannozzo, F, additional, Melcarne, A, additional, Quarta, F, additional, Russo, A G, additional, Carrozzi, G, additional, Cirilli, C, additional, Cavalieri d'Oro, L, additional, Rognoni, M, additional, Fusco, M, additional, Vitale, M F, additional, Usala, M, additional, Cusimano, R, additional, Mazzucco, W, additional, Michiara, M, additional, Sgargi, P, additional, Boschetti, L, additional, Borciani, E, additional, Seghini, P, additional, Maule, M M, additional, Merletti, F, additional, Tumino, R, additional, Mancuso, P, additional, Vicentini, M, additional, Cassetti, T, additional, Sassatelli, R, additional, Falcini, F, additional, Giorgetti, S, additional, Caiazzo, A L, additional, Cavallo, R, additional, Cesaraccio, R, additional, Pirino, D R, additional, Contrino, M L, 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Published
2018
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23. Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia

Author

Rumyantseva, Y. V., Karachunsky, A. I., Aleinikova, O. V., Fechina, L. G., Shamardinal, A. V., Litvinov, D. V., Ponomareva, N. I., Boichenko, E. G., Dudkin, S. A., Streneva, O. V., Kondratchik, K. L., Mansurova, E. G., Minkina, L. M., Lapotentova, E. S., Inyushkina, E. V., Yudina, N. B., Pavlova, G. P., Zhukovskaya, E. V., Khlebnikova, O. P., Lagoiko, S. N., Basharova, E. V., Denisov, R. E., Zlobina, V. D., Banshchikova, E. S., Aslanyan, K. S., Kondakova, E. V., Tselousova, Myakova, N. V., Turobova, T. V., Ryskal, O. V., Chipsanova, N. F., Varfolomeyeva, S. R., and Rumyantsev, A. G.

Subjects
Male, Adolescent, Dose-Response Relationship, Drug, lcsh:R, Age Factors, Infant, lcsh:Medicine, acute lymphoblastic leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Disease-Free Survival, Drug Administration Schedule, Russia, efficiency of therapy, children, Recurrence, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Child
Abstract

Aim. To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children. Subjects and methods. A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008. Results. With the median observation of 4.12 years, 7-year event-free survival (EFS) was 73±13%; overall survival (OS) 78±2%; relapse-free survival 82±1%. The rates of EFS and OS were equal and amounted to 76±2 and 80±2% in the standard-risk group (SRG) and intermediate-risk group (ImRG), respectively. In the high-risk group (HRG) patients, EFS and OS were as high as 30±6 and 37±6%, respectively. The frequency of relapses with central nervous system lesion was as much as 4.7% in all the patients, 6-year cumulative risk for isolated neurorecurrences being 2.5% in the SRG patients. Adolescents, patients with the baseline leukocytosis (more than 100109/l), and those with a splenic size of over 4 cm or more from the costal arch margin had substantially worse survival rates. A poor early response to therapy (on induction days 8 and 15) was also associated with its lower efficiency. Conclusion. Despite a considerable rise in the number of centers and a slight increase in the intensity of therapy, the results of the new ALL-MB-2002 protocol are as minimum equivalents obtained in the use of the previous ALL-MB-91 protocol. A significant improvement in the overall results of therapy and a reduction in the cumulative risk for isolated neurorecurrences were noted in the ImRG patients.

Published
2010

27. Age-related characteristics of the efficacy of different glucocorticosteroids in the therapy of acute lymphoblastic leukemia

Author

Karachunsky, A. I., primary, Rumyantseva, Yu. V., additional, Lagoiko, S. N., additional, Bührer, C., additional, Tallen, G., additional, Aleinikova, O. V., additional, Bydanov, O. I., additional, Korepanova, N. V., additional, Baidun, L. V., additional, Nasedkina, T. V., additional, Stackelberg, A. Von, additional, Novichkova, G. A., additional, Maschan, A. A., additional, Litvinov, D. V., additional, Ponomareva, N. I., additional, Kondratchik, K. L., additional, Mansurova, E. G., additional, Fechina, L. G., additional, Streneva, O. V., additional, Yudina, N. B., additional, Sharapova, G. R., additional, Shamardina, A. V., additional, Gerbek, I. E., additional, Shapochnik, A. P., additional, Rumyantsev, A. G., additional, and Henze, G., additional

Published
2015
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30. DEVELOPMENT OF THE PRINCIPLES TO CREATE A DIAGNOSTIC KIT TO ASSESS DRUG SENSITIVITY OF leukemIC cells

Author

Svirnovskiy, A. I., primary, Sergiyenko, T. F., additional, Pasiukov, V. V., additional, Taras, I. B., additional, Bakun, A. V., additional, Vasilevich, A. S., additional, Stezhkin, A. V., additional, Dreichuk, N. A., additional, Aleinikova, O. V., additional, Shman, T. V., additional, Smirnova, L. A., additional, and Kolbasko, L. V., additional

Published
2011
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35. Non-Hodgkin's lymphomas in children; clinical, diagnostic and therapeutic characteristics (data from clinics of Russia and Belarus)

Author

Samochatova, E. V., Aleinikova, O. V., Belikova, L. Yu, Boridko, A. N., Borisevich, N. V., Virivskaya, M. V., Glushkov, D. V., Dudkin, S. A., Egorov, V. P., Karachunsky, A. I., Kondratchik, K. L., Kozlov, V. K., Kozhanova, O. Yu, Kravchenko, E. G., Kukushkina, I. P., Kurilova, I. V., Lebedev, V. V., Luzhina, I. I., Matyushenko, L. I., Mityaeva, V. V., Morgunova, M. A., Myakova, N. V., Ostrovskaya, A. V., Pavlov, A. D., Polischuk, V. B., Popova, N. A., Privalova, L. P., Ryko, E. A., Timakov, A. M., Tyukalova, N. R., Fedorova, A. S., Shumilova, I. V., and Alexander Rumyantsev

36. Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

Author

Bonaventure, Audrey, Harewood, Rhea, Stiller, Charles A, Gatta, Gemma, Clavel, Jacqueline, Stefan, Daniela C, Carreira, Helena, Spika, Devon, Marcos-Gragera, Rafael, Peris-Bonet, Rafael, Piã±eros, Marion, Sant, Milena, Kuehni, Claudia E, Murphy, Michael F. G, Coleman, Michel P, Allemani, Claudia, Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S. H., El Mistiri, M. M., Bayo, S., Malle, B., Manraj, S. S., Sewpaul-Sungkur, R., Fabowale, Null, Ogunbiyi, O. J., Bradshaw, D., Somdyala, N. I. M., Stefan, D. C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., Gonzã¡lez, M. S., Laura, E. A., Espinola, S. B., Calabrano, G. H., Carballo Quintero, B., Fita, R., Garcilazo, D. A., Giacciani, P. L., Diumenjo, M. C., Laspada, W. D., Green, M. A., Lanza, M. F., Ibaã±ez, S. G., Lima, C. A., de Oliveira, E. Lobo, Daniel, C., Scandiuzzi, C., De Souza, P. C. F., Melo, C. D., Del Pino, K., Laporte, C., Curado, M. P., de Oliveira, J. C., Veneziano, C. L. A., Veneziano, D. B., Alexandre, T. S., Verdugo, A. S., Azevedo e. Silva, G., Galaz, J. C., Moya, J. A., Herrmann, D. A., Vargas, S., Herrera, V. M., Uribe, C. J., Bravo, L. E., Arias-Ortiz, N. E., Jurado, D. M., Yã©pez, M. C., Galã¡n, Y. H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M. L., Jaramillo, L., Quinto, R., Cueva, P., Yã©pez, J. G., Torres-Cintrón, C. R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A. J., Woods, R. R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F. R., Ryan, S., Hannah, H., Dewar, R. A. D., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D. E., Mcclure, C., Vriends, K. A., Bertrand, C., Louchini, R., Robb, K. I., Stuart-Panko, H., Demers, S., Wright, S., George, J. T., Shen, X., Brockhouse, J. T., O'Brien, D. K., Ward, K. C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A. G., Vigneau, F., Mackinnon, J. A., Wohler, B., Bayakly, A. R., Clarke, C. A., Glaser, S. L., West, D., Green, M. D., Hernandez, B. Y., Johnson, C. J., Jozwik, D., Charlton, M. E., Lynch, C. F., Huang, B., Tucker, T. C., Deapen, D., Liu, L., Hsieh, M. C., X. C., Wu, Stern, K., Gershman, S. T., Knowlton, R. C., Alverson, J., Copeland, G. E., Rogers, D. B., Lemons, D., Williamson, L. L., Hood, M., Hosain, G. M., Rees, J. R., Pawlish, K. S., Stroup, A., Key, C., Wiggins, C., Kahn, A. R., Schymura, M. J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S. S., Rubertone, J. J., Slack, S. J., Fulton, J. P., Rousseau, D. L., Janes, T. A., Schwartz, S. M., Bolick, S. W., Hurley, D. M., Richards, J., Whiteside, M. A., Nogueira, L. M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D. G., Cheteri, MB Keitheri, Farley, S., Hudson, A. G., Borchers, R., Stephenson, L., Espinoza, J. R., Weir, H. K., Edwards, B. K., Wang, N., Yang, L., Chen, J. S., Song, G. H., X. P., Gu, Zhang, P., H. M., Ge, Zhao, D. L., Zhang, J. H., Zhu, F. D., Tang, J. G., Shen, Y., Wang, J., Q. L., Li, Yang, X. P., Dong, J., Li, W., Cheng, L. P., Chen, J. G., Huang, Q. H., Huang, S. Q., Guo, G. P., Wei, K., Chen, W. Q., Zeng, H., Demetriou, A. V., Pavlou, P., Mang, W. K., Ngan, K. C., Kataki, A. C., Krishnatreya, M., Jayalekshmi, P. A., Sebastian, P., Sapkota, S. D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B. G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Pathy, N. Bhoo, Chimedsuren, O., Tuvshingerel, S., Al Khater, A. H. M., Al-Eid, H., Jung, K. W., Won, Y. J., Chiang, C. J., Lai, M. S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S. L., Sriplung, H., Eser, S., Yakut, C. I., Hackl, M., Mã¼hlbã¶ck, H., Oberaigner, W., Zborovskaya, A. A., Aleinikova, O. V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Å ekerija, M., Zvolskã½, M., Engholm, G., Storm, H., Innos, K., Mã¤gi, M., Malila, N., Seppã¤, K., Jã©gu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A. M., Faivre, J., Guizard, A. V., Bouvier, V., Launoy, G., Arveux, P., Maynadiã©, M., Mounier, M., Fournier, E., Woronoff, A. S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trã©tarre, B., Colonna, M., Cowppli-Bony, A., Moliniã©, F., Bara, S., Degrã©, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estãve, J., Bray, F., Piã±eros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S. R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R. A., Kumar, V., Ã'lafsdóttir, E. J., Tryggvadã³ttir, L., Comber, H., Walsh, P. M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M. F., Usala, M., Cusimano, R., Mazzucco, Walter, Michiara, M., Sgargi, P., Maule, M. M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M. L., Tisano, F., Fanetti, A. C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M. A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A. 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Subjects
childhood leukaemia, Cancer registrie, leukemia, cancer, childhood cancer, Socio-culturale, Hematology, Settore MED/42 - Igiene Generale E Applicata, Hematology, childhood leukaemia, cancer survival, cancer survival
Abstract

BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. METHODS: Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (

38. Recent thymic emigrants, T regulatory cells, and BAFF level in children with X-linked agammaglobulinaemia in association with chronic respiratory disease.

Author

Sharapova SO, Pashchenko OE, Guryanova IE, Migas AA, Kondratenko IV, and Aleinikova OV

Subjects
Adolescent, Agammaglobulinemia complications, Bronchitis complications, Cell Separation, Child, Child, Preschool, Chronic Disease, Female, Flow Cytometry, Genetic Diseases, X-Linked complications, Humans, Immunologic Memory, Immunophenotyping, Male, Sinusitis complications, Agammaglobulinemia immunology, B-Cell Activating Factor metabolism, Bronchitis immunology, Genetic Diseases, X-Linked immunology, Sinusitis immunology, T-Lymphocyte Subsets immunology, T-Lymphocytes, Regulatory immunology, Thymocytes immunology
Abstract

Background: X-linked agammaglobulinaemia (XLA) is a genetic disorder affecting B cell maturation, which is characterised by a low number of B cells, agammaglobulinaemia and increased susceptibility to a variety of bacterial infections. This study was performed to assess T cell subpopulations in a group of children with XLA in association with chronic respiratory disease (CRD)., Methods: Numbers of T cell subpopulations (CD3+, CD4+, CD8+, CD3+DR+, naïve, memory, recent thymic emigrants (RTE), regulatory T cells, follicular T helpers) were measured by eight-colour flow cytometry in 22 XLA patients and 50 controls. BAFF level was measured by ELISA., Results: XLA patients with CRD had a significantly lower percentage of RTE numbers and Tregs, while significantly higher absolute counts of lymphocytes, CD3+, CD8+, CD3+DR+ and CD4+CD45RO+ T cells were detected as compared with healthy controls. In patients with XLA without CRD, the number of follicular T helper cells was altered significantly (percentage and absolute), as compared with healthy controls. Additionally, they had significantly higher counts (percentage and absolute) of CD4+CD45RA+ cells and lower percentage of CD4+CD45RO+ cells in comparison with healthy controls., Conclusions: Our study affords new information concerning CRD and T cell subsets that differentiate or are maintained in the absence of B cells in children with XLA. T cell's homeostasis depends on the presence of chronic respiratory disease that may be caused by the delay in diagnosis., (Copyright © 2017 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.)

Published
2018
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39. Drug resistance associated properties of blasts subpopulations with different CD34 expression in childhood acute lymphoblastic leukemia (ALL).

Author

Shman TV, Fedasenka UU, Savitski VP, Kustanovich AM, and Aleinikova OV

Subjects
ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1 genetics, ATP Binding Cassette Transporter, Subfamily G, Member 2, ATP-Binding Cassette Transporters genetics, Adolescent, Cell Line, Tumor, Child, Child, Preschool, Female, Humans, Infant, Male, Neoplasm Proteins genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma metabolism, Proto-Oncogene Proteins c-bcl-2 genetics, RNA, Messenger genetics, RNA, Messenger metabolism, Vault Ribonucleoprotein Particles genetics, Antigens, CD34 analysis, Drug Resistance, Neoplasm genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Abstract

Aim: The objective of this study was to investigate expression of drug resistance associated genes in CD34+ and CD34- leukemic subpopulations in childhood acute lymphoblastic leukemia (ALL)., Methods: ALL samples with heterogeneous CD34 expression were separated into CD34-positive and CD34-negative subpopulations and mRNA levels of MDR1, LRP, BCRP and BCL-2 genes were compared., Results: BCL-2 gene expression levels did not differ significantly between CD34+ vs CD34- subpopulations in most analyzed ALL cases. Oppositely, MDR1 gene had >two-fold differences in expression levels between subpopulations in the majority of ALL cases. In T-lineage ALL CD34- fractions had increased level of BCRP and LRP genes in comparison with CD34+ ones whereas in most of B-lineage ALL expression of these genes did not differ., Conclusion: It was not found the unique pattern of resistance related genes expression in CD34+ vs CD34- subpopulations. However, in majority of studied pediatric ALL cases with CD34 heterogeneous expression one of subpopulations (positive or negative) could have an advantage for survival through elevated expression of drug resistance related genes.

Published
2011

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