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969 results on '"Alegre M"'

2. Delayed Cytotoxic T Lymphocyte–Associated Protein 4–Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection

Author

Young, JS, Chen, J, Miller, ML, Vu, V, Tian, C, Moon, JJ, Alegre, M-L, Sciammas, R, and Chong, AS

Subjects
Biomedical and Clinical Sciences, Immunology, Transplantation, Rare Diseases, Organ Transplantation, Inflammatory and immune system, Animals, B-Lymphocytes, CTLA-4 Antigen, Female, Graft Rejection, Graft Survival, Heart Transplantation, Immunoconjugates, Isoantibodies, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, T-Lymphocytes, Cytotoxic, Transplantation, Homologous, basic (laboratory) research, science, immunosuppression, immune modulation, organ transplantation in general, immunobiology, alloantibody, animal models: murine, B cell biology, immunosuppressant, fusion proteins and monoclonal antibodies: belatacept, immunosuppressive regimens, rescue, basic (laboratory) research/science, immunosuppression/immune modulation, Medical and Health Sciences, Surgery, Clinical sciences
Abstract

Antibody-mediated rejection has emerged as the leading cause of late graft loss in kidney transplant recipients, and inhibition of donor-specific antibody production should lead to improved transplant outcomes. The fusion protein cytotoxic T lymphocyte-associated protein 4-immunoglobulin (CTLA4-Ig) blocks T cell activation and consequently inhibits T-dependent B cell antibody production, and the current paradigm is that CTLA4-Ig is effective with naïve T cells and less so with activated or memory T cells. In this study, we used a mouse model of allosensitization to investigate the efficacy of continuous CTLA4-Ig treatment, initiated 7 or 14 days after sensitization, for inhibiting ongoing allospecific B cell responses. Delayed treatment with CTLA4-Ig collapsed the allospecific germinal center B cell response and inhibited alloantibody production. Using adoptively transferred T cell receptor transgenic T cells and a novel approach to track endogenous graft-specific T cells, we demonstrate that delayed CTLA4-Ig minimally inhibited graft-specific CD4(+) and T follicular helper responses. Remarkably, delaying CTLA4-Ig until day 6 after transplantation in a fully mismatched heart transplant model inhibited alloantibody production and prevented acute rejection, whereas transferred hyperimmune sera reversed the effects of delayed CTLA4-Ig. Collectively, our studies revealed the unexpected efficacy of CTLA4-Ig for inhibiting ongoing B cell responses even when the graft-specific T cell response was robustly established.

Published
2016

16. Un recorrido por la residencia en bioquímica

Author

Spadafora, M., Grau, M. E., Alcalde, M. B., Shepherd Safar, M., and Alegre, M.

Subjects
Ciencias Médicas y de la Salud, Bioquímica, Pediatría, Residencia
Abstract

En el año 1977, la apertura de la Residencia Básica en Bioquímica Clínica en el Hospital de Niños “Sor María Ludovica” dio lugar a un espacio de formación para profesionales bioquímicos en el ámbito hospitalario-asistencial del Sistema Público de Salud con un fuerte perfil pediátrico. Con el objetivo de dar respuesta a la necesidad de contar con bioquímicos especializados en distintas áreas del Laboratorio, en el año 1999 se incorporó a la sede la primera Residencia Postbásica en Bioquímica con orientación en Microbiología, y desde entonces se sucedió la apertura de Residencias Postbásicas en Bioquímica con distintas orientaciones, entre ellas Biología Molecular, Endocrinología, Hematología, Inmunología y Toxicología.

Published
2022

21. ARDIS: Knowledge-Based Dynamic Architecture for Real-Time Surface Visual Inspection

Author

Martín, D., Rincón, M., García-Alegre, M. C., Guinea, D., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Mira, José, editor, Ferrández, José Manuel, editor, Álvarez, José R., editor, de la Paz, Félix, editor, and Toledo, F. Javier, editor

Published
2009
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