14 results on '"Aldemir, Hatice"'
Search Results
2. A Digital Health Intervention for Stress and Anxiety Relief in Perioperative Care: Protocol for a Feasibility Randomized Controlled Trial
- Author
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Kondylakis, Haridimo, Chicchi Giglioli, Irene Alice Margherita, Katehakis, Dimitrios G, Aldemir, Hatice, Zikas, Paul, Papagiannakis, George, Hors-Fraile, Santiago, González-Sanz, Pedro L, Apostolakis, Konstantinos C, Stephanidis, Constantine, Núñez-Benjumea, Francisco J, Baños-Rivera, Rosa M, Fernandez-Luque, Lui, Kouroubali, Angelina, Chicchi Giglioli, Irene Alice (ORCID:0000-0003-2577-0039), Kondylakis, Haridimo, Chicchi Giglioli, Irene Alice Margherita, Katehakis, Dimitrios G, Aldemir, Hatice, Zikas, Paul, Papagiannakis, George, Hors-Fraile, Santiago, González-Sanz, Pedro L, Apostolakis, Konstantinos C, Stephanidis, Constantine, Núñez-Benjumea, Francisco J, Baños-Rivera, Rosa M, Fernandez-Luque, Lui, Kouroubali, Angelina, and Chicchi Giglioli, Irene Alice (ORCID:0000-0003-2577-0039)
- Abstract
Background: Stress and anxiety are psychophysiological responses commonly experienced by patients during the perioperative process that can increase presurgical and postsurgical complications to a comprehensive and positive recovery. Preventing and intervening in stress and anxiety can help patients achieve positive health and well-being outcomes. Similarly, the provision of education about surgery can be a crucial component and is inversely correlated with preoperative anxiety levels. However, few patients receive stress and anxiety relief support before surgery, and resource constraints make face-to-face education sessions untenable. Digital health interventions can be helpful in empowering patients and enhancing a more positive experience. Digital health interventions have been shown to help patients feel informed about the possible benefits and risks of available treatment options. However, they currently focus only on providing informative content, neglecting the importance of personalization and patient empowerment.Objective: This study aimed to explore the feasibility of a digital health intervention called the Adhera CARINAE Digital Health Program, designed to provide evidence-based, personalized stress-and anxiety-management methods enabled by a comprehensive digital ecosystem that incorporates wearable, mobile, and virtual reality technologies. The intervention program includes the use of advanced data-driven techniques for tailored patient education and lifestyle support.Methods: The trial will include 5 hospitals across 3 European countries and will use a randomized controlled design including 30 intervention participants and 30 control group participants. The involved surgeries are cardiopulmonary and coronary artery bypass surgeries, cardiac valve replacement, prostate or bladder cancer surgeries, hip and knee replacement, maxillofacial surgery, or scoliosis. The control group will receive standard care, and the intervention group will additionally be
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- 2022
3. A Digital Health Intervention for Stress and Anxiety Relief in Perioperative Care: Protocol for a Feasibility Trial. (Preprint)
- Author
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Kondylakis, Haridimos, primary, Chicchi Giglioli, Irene Alice, additional, Katehakis, Dimitrios G., additional, Aldemir, Hatice, additional, Zikas, Paul, additional, Papagiannakis, George, additional, Hors-Fraile, Santiago, additional, González-Sanz, Pedro L., additional, Apostolakis, Konstantinos C., additional, Stephanidis, Constantine, additional, Núñez-Benjumea, Francisco J., additional, Baños-Rivera, Rosa M., additional, Fernandez-Luque, Luis, additional, and Kouroubali, Angelina, additional
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- 2022
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4. Murine models for evaluating the allergenicity of novel proteins and foods
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Aldemir, Hatice, Bars, Rémi, and Herouet-Guicheney, Corinne
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- 2009
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5. Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells
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Aldemir, Hatice
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- 2008
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6. The effect of time of day and exercise on platelet functions and platelet–neutrophil aggregates in healthy male subjects
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Aldemir, Hatice and Kiliç, Nedret
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- 2005
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7. Expression of CD94–NKG2A inhibitory receptor is restricted to a subset of CD8 + T cells
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Braud, Veronique M., Aldemir, Hatice, Breart, Beatrice, and Ferlin, Walter G.
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- 2003
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8. Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor 1
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Aldemir, Hatice, Prod'homme, Virginie, Dumaurier, Marie-Jeanne, Retiere, Christelle, Poupon, Gwenola, Cazareth, Julie, Bihl, Franck, Braud, Veronique, Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang [Nantes], RETIERE, Christelle, and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
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[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,[SDV.BC] Life Sciences [q-bio]/Cellular Biology - Abstract
International audience; Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-␥ secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-␥ production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.
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- 2005
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9. Egzersiz kronobiyolojisinin hematolojik, metabolik, hemodinamik ve kardiyovasküler parametreler ile oksidatif stres oluşumu üzerine etkisi
- Author
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Aldemir, Hatice, Kılıç, Nedret, and Diğer
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Cardiovascular diseases ,Biyokimya ,Free radicals ,Biochemistry ,Exercise ,Chronobiology - Abstract
214 6. ÖZET Bu çalışmada 12 sağlıklı fiziksel olarak aktif erkekte egzersizin ve egzersiz zamanının hematolojik, metabolik, hemodinamik ve kardiyovasküler parametreler ile oksidatif stres oluşumu üzerine etkileri incelenmiştir. Bu amaçla 12 denek bisiklet ergometresinde en az 4 gün arayla sabah ve akşam, maksimum oksijen kapasitelerinin % 70'indeki yoğunlukta egzersiz yaptılar. Her biri 30 dakika olan dinlenme, egzersiz ve toparlanma sürecinde kor sıcaklığı, deri sıcaklığı, nabız ve deri kan akımı sürekli olarak, kan basıncı ve ön kol kan akımı egzersiz öncesi ve sonrasında ölçülmüş, yapılan ölçümlerden direnç ve kondüktans hesaplanmıştır. Egzersiz öncesi ve sonrasında alınan kan örneklerinde RBC, WBC ve platelet sayımı ile Hb ve Hct değerleri ölçülmüştür. Platelet aktivasyonunun bir göstergesi olarak platelet agregasyonu ve p- tromboglobulin ölçümleri yapılmıştır. Egzersiz sonucu artan oksijen kullanımı nedeni ile oluşabilecek oksidatif stresin zamana bağlı değişimi MDA düzeylerinin ölçülmesi ile izlenmiştir. Egzersiz öncesinde vasküler direnç dışındaki kardiyovasküler parametreler, hemodinamik ölçümler, Hb, Hct, RBC, MCHC, lökosit ve platelet sayısı akşamlan daha yüksek saptanırken, egzersiz sonrasında SBF, SVR, SVC, FVR, Hb, Hct, RBC, MCV ölçümleri ile plateletlerin aktivasyonunu gösteren p-tromboglobulîn düzeyleri ile oksidatif stres belirteci MDA sabahları daha yüksek saptanmıştır. Tüm parametrelerin sirkadiyan ritme sahip olduğu gözlenmiştir. 215 7. SUMMARY The Effect of Exercise and Exercise Chronobiology on Hematological, Biochemical, Haemodynamic and Cardiovascular Parameters and Oxidative Stress In this study 12 healthy, physically active, male subjects have been volunteered for examining the effects of exercise and the exercise time on hematological, biochemical, haemodynamic and cardiovascular parameters and oxidative stress. Twelve subjects cycled on a bicycle ergometer at their 70 % VOw for two days at least a 4 day interval, one day in the morning and the other day in the evening. During 30 minutes of each resting, exercise and recovery periods, the core and skin temperatures, heart rate and skin blood flow were measured continuously whereas blood pressure and forearm blood flow were measured before and after exercise. Resistance and conductance were calculated by using the obtained data. RBC, WBC and the platelet counts and the measurement of Hb and Hct levels were carried out before and after exercise. The aggregation and p-thromboglobulin levels were examined to evaluate platelet activation. MDA levels were measured to examine the oxidative stress which may result from increased oxygen consumption. Before exercise other than the vascular resistance the cardiovascular parameters, hemodynamic measurements, Hb, Hct, RBC, MCHC, leucocyte and platelet counts were at high levels in the evening. After exercise SBF, SVR, SVC, FVR, Hb, Hct, RBC, MCV measurements, 0-thromboglobulin and MDA levels were higher in the morning than in the evening. It is observed that all the parameters had circadian rithmicity. 234
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- 1999
10. Hücresel antioksidan savunma sistemindeki rolü açısından kanserde serum selenyum düzeylerinin spektrofluorometrik olarak değerlendirilmesi
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Aldemir, Hatice, Torun, Meral, and Diğer
- Subjects
Selenium ,Biyokimya ,Neoplasms ,Free radicals ,Biochemistry ,Antioxidants ,Spectrometry-fluorescence - Abstract
267 - ÖZET öncelikle kanser olmak Üzere, çeşitli hastalıklar ile selenyum eksikliği arasında anlamlı korelasyon olduğunu ortaya koyan çeşitli epidemiyolojik ve klinik çalışmalar bulunmaktadır. Bu çalışmada kanserli (n=101) ve sağlıklı bireylerde (n=101) serum Se düzeyleri saptanmıştır. Kanserli olgular aşağıdaki primer tümörleri içeren bireylerden oluşmaktadır: Mide (n=10), Kolon (n=10), Larinks (n=10), Serviks (n=10), Over (n=10), Prostat (n=10), Meme (n=10), Mesane (n=10) ve Diğer bölgeler (n=ll). Kontrol grubu ve tüm kanserli olgularda serum Se düzeylerinin ortalaması (±SD) sırasıyla 94.1 ng/L (±12.5) ve 69.2 M-g/L (±11.1) olarak saptanmıştır. Kanserli ve normal bireylerdeki serum Se düzeylerine girişimde bulunabilecek yas, cinsiyet, quetelet indeksi (kg/m2), sigara içme durumu, alkol alımı ve diyet gibi faktörlerin etkileri incelenmiştir. Bunun yanı sıra kanser türüne bağlı olarak serum Se düzeylerinin değişimi tartışılmıştır. Verilerimiz kanser türü ile serum Se düzeyleri arasında over kanserliler hariç, çok belirgin bir ilişki olmadığını ortaya koymaktadır. Kanser ile ilişkili olarak serum Se düzeyleri konusunda yapılacak olan prospektif çalışmalar bu ilişki konusunda daha fazla bilgi sağlayabilir. - 268 - SUMMARY In various clinical and epidemiological studies it has been observed that there is an inverse correlation between serum selenium levels and the incidence of certain types of cancer. In this study serum Se levels in cancer patients (n=101) and healthy controls (n=101) were measured. The cancer group included patients with the following primary site tumors: Stomach (n=10), Colon (n=10), Larynx (n=10), Lung (n=10), Cervix (n=10), Over (n=10), Prostat (n=10), Breast (n=10), Bladder (n=10) and Other sites (n=ll). The mean (±SD) values for Se were found to be 94.1 M.g/L (±12.5) in controls and 69.2 ng/L (±11.1) in the cases. Cases and controls were compared with respects to a number of potentially confounding factors: age, sex, quetelet index (kg/mz ), smoking status, alcohol intake and diatary intake. Serum Se concentrations were also discussed releated to the spesific site of cancer. Our data indicate that there are no apparent associations between serum Se concentration and several types of cancer expect over Ca. Thus, prospective studies which will be done on serum Se levels as related to cancer may provide more information on this relationship. 280
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- 1993
11. Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific
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Hansasuta, Pokrath, primary, Dong, Tao, additional, Thananchai, Hathairat, additional, Weekes, Michael, additional, Willberg, Christian, additional, Aldemir, Hatice, additional, Rowland-Jones, Sarah, additional, and Braud, Veronique M., additional
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- 2004
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12. Expression of CD94–NKG2A inhibitory receptor is restricted to a subset of CD8+ T cells
- Author
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Braud, Veronique M., primary, Aldemir, Hatice, additional, Breart, Beatrice, additional, and Ferlin, Walter G., additional
- Published
- 2003
- Full Text
- View/download PDF
13. Stress Reduction in Perioperative Care: Feasibility Randomized Controlled Trial.
- Author
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Kondylakis H, Giglioli IAC, Katehakis D, Aldemir H, Zikas P, Papagiannakis G, Hors-Fraile S, González-Sanz PL, Apostolakis K, Stephanidis C, Núñez-Benjumea FJ, Baños-Rivera RM, Fernandez-Luque L, and Kouroubali A
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- Adult, Aged, Female, Humans, Male, Middle Aged, Anxiety psychology, Mobile Applications, Patient Education as Topic methods, Telemedicine, Feasibility Studies, Perioperative Care methods, Perioperative Care psychology, Stress, Psychological psychology, Stress, Psychological therapy
- Abstract
Background: Patients undergoing surgery often experience stress and anxiety, which can increase complications and hinder recovery. Effective management of these psychological factors is key to improving outcomes. Preoperative anxiety is inversely correlated with the amount of information patients receive, but accessible, personalized support remains limited, especially in preoperative settings. Face-to-face education is often impractical due to resource constraints. Digital health (DH) interventions offer a promising alternative, enhancing patient engagement and empowerment. However, most current tools focus on providing information, overlooking the importance of personalization and psychological support., Objective: This study aimed to assess the viability of a DH intervention known as the Adhera CARINAE DH Program. This program is specifically designed to offer evidence-based and personalized stress- and anxiety-management techniques. It achieves this by using a comprehensive digital ecosystem that incorporates wearable devices, mobile apps, and virtual reality technologies. The intervention program also makes use of advanced data-driven techniques to deliver tailored patient education and lifestyle support., Methods: A total of 74 patients scheduled for surgery across 4 hospitals in 3 European countries were enrolled in this study from September 2021 to March 2022. Surgeries included cardiopulmonary and coronary artery bypass surgeries, cardiac valve replacements, prostate or bladder cancer surgeries, hip and knee replacements, maxillofacial surgery, and scoliosis procedures. After assessment for eligibility, participants were randomized into 2 groups: the intervention group (n=23) received the Adhera CARINAE DH intervention in addition to standard care, while the control group (n=27) received standard care alone. Psychological metrics such as self-efficacy, self-management, and mental well-being were assessed before and after the intervention, alongside physiological markers of stress., Results: The intervention group demonstrated significant improvements across several psychological outcomes. For example, Visual Analogue Scale Stress at the hospital improved at admission by 5% and at hospital discharge by 11.1% and Visual Analogue Scale Pain at admission improved by 31.2%. In addition, Hospital Anxiety and Depression Scale Anxiety after surgery improved by 15.6%, and Positive and Negative Affect Scale-Negative at hospital admission improved by 17.5%. Overall, patients in the intervention study spent 17.12% less days in the hospital. Besides these individual scores, the intervention group shows more positive relationships among the psychological dimensions of self-efficacy, self-management, and mental well-being, suggesting that the CARINAE solution could have a positive effect and impact on the reduction of stress and negative emotions., Conclusions: Our results provide an important first step toward a deeper understanding of optimizing DH solutions to support patients undergoing surgery and for potential applications in remote patient monitoring and communication., Trial Registration: ClinicalTrials.gov NCT05184725; https://clinicaltrials.gov/study/NCT05184725., International Registered Report Identifier (irrid): RR2-10.2196/38536., (©Haridimos Kondylakis, Irene Alice Chicchi Giglioli, Dimitrios Katehakis, Hatice Aldemir, Paul Zikas, George Papagiannakis, Santiago Hors-Fraile, Pedro L González-Sanz, Konstantinos Apostolakis, Constantine Stephanidis, Francisco J Núñez-Benjumea, Rosa M Baños-Rivera, Luis Fernandez-Luque, Angelina Kouroubali. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 07.01.2025.)
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- 2025
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14. Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.
- Author
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Aldemir H, Prod'homme V, Dumaurier MJ, Retiere C, Poupon G, Cazareth J, Bihl F, and Braud VM
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- Antigens, Surface immunology, Antigens, Surface metabolism, CD3 Complex metabolism, Cytotoxicity, Immunologic, Humans, Interferon-gamma biosynthesis, Killer Cells, Natural immunology, Lectins, C-Type immunology, Ligands, NK Cell Lectin-Like Receptor Subfamily B, Protein Binding, Receptors, Antigen, T-Cell metabolism, Receptors, Cell Surface immunology, Signal Transduction, T-Lymphocytes metabolism, Antigens, Surface physiology, Lectins, C-Type metabolism, Lectins, C-Type physiology, Receptors, Cell Surface metabolism
- Abstract
Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-gamma secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-gamma production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.
- Published
- 2005
- Full Text
- View/download PDF
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